Genomes and Genes
Summary: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
Publications411 found, 100 shown here
- Chagas diseaseAnis Rassi
Division of Cardiology, Anis Rassi Hospital, Goiania, GO, Brazil
Lancet 375:1388-402. 2010b>Chagas disease is a chronic, systemic, parasitic infection caused by the protozoan Trypanosoma cruzi, and was discovered in 1909...
- The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applicationsBianca Zingales
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Avenida Professor Lineu Prestes 748, 05508 000 Sao Paulo, SP, Brazil
Infect Genet Evol 12:240-53. 2012..The human infection, named Chagas disease, is a major public health problem for Latin America. T...
- Chagas disease: a Latin American health problem becoming a world health problemGabriel A Schmunis
Health Surveillance, Disease Prevention and Control, Pan American Health Organization, Regional Office of the World Health Organization, 525 23th Street N W, Washington, DC 20037, USA
Acta Trop 115:14-21. 2010..and/or economic stagnation stimulated the flow of migration from the 17 Latin American countries endemic for Chagas disease to developed countries...
- Global economic burden of Chagas disease: a computational simulation modelBruce Y Lee
Public Health Computational and Operations Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Lancet Infect Dis 13:342-8. 2013As Chagas disease continues to expand beyond tropical and subtropical zones, a growing need exists to better understand its resulting economic burden to help guide stakeholders such as policy makers, funders, and product developers...
- American trypanosomiasis (Chagas disease)Anis Rassi
Division of Cardiology, Anis Rassi Hospital, Avenida José Alves 453, Setor Oeste, Goiania, GO 74110 020, Brazil
Infect Dis Clin North Am 26:275-91. 2012b>Chagas disease, also known as American trypanosomiasis, is a chronic infection caused by Trypanosoma cruzi, a protozoan parasite. It is transmitted to human beings mainly through the feces of infected triatomine bugs...
- The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and eliminationPeter J Hotez
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
PLoS Negl Trop Dis 2:e300. 2008..healthy life years lost from disability, hookworm infection, other soil-transmitted helminth infections, and Chagas disease are the most important NTDs in LAC, followed by dengue, schistosomiasis, leishmaniasis, trachoma, leprosy, and ..
- Mechanisms of Trypanosoma cruzi persistence in Chagas diseaseFnu Nagajyothi
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
Cell Microbiol 14:634-43. 2012Trypanosoma cruzi infection leads to development of chronic Chagas disease. In this article, we provide an update on the current knowledge of the mechanisms employed by the parasite to gain entry into the host cells and establish ..
- Chagas disease in Spain, the United States and other non-endemic countriesJoaquim Gascon
Centre de Salut Internacional, CRESIB, Hospital Clinic, IDIBAPS, C Villarroel, 170, 08036, Barcelona, Spain
Acta Trop 115:22-7. 2010Due to recent trends in migration, there are millions of people from Chagas disease-endemic countries now living in North America, Europe, Australia and Japan, including thousands of people with Trypanosoma cruzi infection...
- Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policyAlvaro Moncayo
Academia Nacional de Medicina, Bogota, Colombia
Mem Inst Oswaldo Cruz 104:17-30. 2009b>Chagas disease, named after Carlos Chagas, who first described it in 1909, exists only on the American Continent...
- Specific chemotherapy of Chagas disease: relevance, current limitations and new approachesJulio A Urbina
Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Acta Trop 115:55-68. 2010..of the development of specific chemotherapeutic approaches for the management of American Trypanosomiasis or Chagas disease is presented, including controversies on the pathogenesis of the disease, the initial efforts that led to the ..
- Contemporary cryptic sexuality in Trypanosoma cruziJuan David Ramírez
Centro de Investigaciones en Microbiologia y Parasitologia Tropical, Universidad de Los Andes, Bogota, Colombia
Mol Ecol 21:4216-26. 2012..Trypanosoma cruzi, which causes Chagas disease, is known to undergo non-Mendelian genetic exchange in the laboratory...
- An estimate of the burden of Chagas disease in the United StatesCaryn Bern
Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 49:e52-4. 2009b>Chagas disease causes the highest burden of any parasitic disease in the Western hemisphere...
- Chagas disease. What is known and what should be improved: a systemic reviewJosé Rodrigues Coura
Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil
Rev Soc Bras Med Trop 45:286-96. 2012This study consists of a broad review on what is known and what should be improved regarding knowledge of Chagas disease, not only through analysis on the main studies published on the topics discussed, but to a large extent based on ..
- The impact of Chagas disease control in Latin America: a reviewJ C P Dias
Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, 30190 002, Brasil
Mem Inst Oswaldo Cruz 97:603-12. 2002Discovered in 1909, Chagas disease was progressively shown to be widespread throughout Latin America, affecting millions of rural people with a high impact on morbidity and mortality...
- Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas diseaseFabiana S Machado
Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Semin Immunopathol 34:753-70. 2012b>Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical disease and a cause of significant morbidity and mortality...
- Oral transmission of Chagas diseaseMaria Aparecida Shikanai-Yasuda
Department of Infectious and Parasitic Diseases, das Clínicas, Faculdade de Medicina, University of Sao Paulo, Brazil
Clin Infect Dis 54:845-52. 2012b>Chagas disease is now an active disease in the urban centers of countries of nonendemicity and endemicity because of congenital and blood and/or organ transplantation transmissions and the reactivation of the chronic disease in smaller ..
- A critical review on Chagas disease chemotherapyJosé Rodriques Coura
Departamento de Medicina Tropical, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, 21045 900 Rio de Janeiro, RJ, Brasil
Mem Inst Oswaldo Cruz 97:3-24. 2002In this "Critical Review" we made a historical introduction of drugs assayed against Chagas disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental use of nitrofurazone...
- International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patientsAlejandro G Schijman
Laboratorio de Biología Molecular de Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular INGEBI CONICET, Buenos Aires, Argentina
PLoS Negl Trop Dis 5:e931. 2011A century after its discovery, Chagas disease still represents a major neglected tropical threat. Accurate diagnostics tools as well as surrogate markers of parasitological response to treatment are research priorities in the field...
- Chagas disease: 100 years after its discovery. A systemic reviewJosé Rodrigues Coura
Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brazil
Acta Trop 115:5-13. 2010Although Chagas disease was only discovered in 1909, it began millions of years ago as an enzootic disease among wild animals. Its transmission to man began accidentally as an anthropozoonosis when mankind invaded wild ecotopes...
- Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruziC A Machado
Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 98:7396-401. 2001..We estimate that the major extant lineages of T. cruzi have diverged during the Miocene or early Pliocene (3-16 million years ago)...
- The United States Trypanosoma cruzi Infection Study: evidence for vector-borne transmission of the parasite that causes Chagas disease among United States blood donorsPaul T Cantey
Epidemic Intelligence Service, Office of Surveillance, Epidemiology, and Laboratory Services, and Division of Parasitic Diseases and Malaria, Center for Global Health, CDC, Atlanta, Georgia 30333, USA
Transfusion 52:1922-30. 2012..cruzi Infection Study was conducted to evaluate the burden of and describe putative risk factors for vector-borne infection in the United States...
- Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)Jose A Castro
Centro de Investigaciones Toxicológicas CEITOX CITEFA CONICET, J B de La Salle 4397, Villa Martelli, Pcia de Buenos Aires 1603, Argentina
Hum Exp Toxicol 25:471-9. 2006..Those processes are fundamentally mediated by cytochrome P450 reductase and cytochrome P450. Other enzymes such as xanthine oxidoreductase or aldehyde oxidase may also be involved...
- Clinical and epidemiological aspects of Chagas diseaseA Prata
Tropical Medicine Departament, Faculdade de Medicina do Triangulo Mineiro, Uberaba, MG, Brazil
Lancet Infect Dis 1:92-100. 2001b>Chagas disease is caused by the protozoan parasite Trypanosoma cruzi...
- Trypanosoma cruzi I diversity: towards the need of genetic subdivision?Felipe Guhl
Centro de Investigaciones en Microbiologia y Parasitologia Tropical, CIMPAT, Universidad de Los Andes, Cra 1 No 18A 10, Bogota, Colombia
Acta Trop 119:1-4. 2011Trypanosoma cruzi the aethiological agent of Chagas disease, a complex zoonoses that affects the American continent is a genetically variable parasite subdivided into six Discrete Typing Units (DTUs). T...
- Adverse events after the use of benznidazole in infants and children with Chagas diseaseJaime Altcheh
Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños R Gutiérrez, Gallo 1330, Buenos Aires 1425, Argentina
Pediatrics 127:e212-8. 2011b>Chagas disease is caused by infection with Trypanosoma cruzi. In adults, treatment with benznidazole is associated with a high incidence of adverse drug reactions (ADRs)...
- Public street lights increase house infestation by the Chagas disease vector Triatoma dimidiataFreddy Santiago Pacheco-Tucuch
Laboratorio de Parasitologia, Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico
PLoS ONE 7:e36207. 2012Triatoma dimidiata is one of the primary vectors of Chagas disease. We previously documented the spatio-temporal infestation of houses by this species in the Yucatan peninsula, Mexico, and found that non-domiciliated triatomines were ..
- Certifying the interruption of Chagas disease transmission by native vectors: cui bono?Fernando Abad-Franch
Instituto Leônidas e Maria Deane Fiocruz, Manaus, AM, Brasil
Mem Inst Oswaldo Cruz 108:251-4. 2013Certifying the absence of Chagas disease transmission by native vectors lacks scientific grounds and weakens long-term control-surveillance systems to the detriment of people living under risk conditions...
- Risks of endemicity, morbidity and perspectives regarding the control of Chagas disease in the Amazon RegionJosé Rodrigues Coura
Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brasil
Mem Inst Oswaldo Cruz 107:145-54. 2012b>Chagas disease, in the Amazon Region as elsewhere, can be considered an enzootic disease of wild animals or an anthropozoonosis, an accidental disease of humans that is acquired when humans penetrate a wild ecosystem or when wild ..
- Comparative phylogeography of Trypanosoma cruzi TCIIc: new hosts, association with terrestrial ecotopes, and spatial clusteringArlei Marcili
Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brazil
Infect Genet Evol 9:1265-74. 2009..Analysis of ITS1 rDNA sequences disclosed clusters of TCIIc isolates in accordance with their geographic origin, independent of their host species...
- Severity of chronic Chagas disease is associated with cytokine/antioxidant imbalance in chronically infected individualsRicardo Pérez-Fuentes
Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, 13 Sur 2901 Col Volcanes, C P 72000, Pue, Puebla, Mexico
Int J Parasitol 33:293-9. 2003Understanding the pathogenic mechanisms in chronic Chagas disease, a major cause of morbidity and mortality in Latin America, is essential for the design of rational therapeutic strategies...
- Insecticide resistance of Triatoma infestans (Hemiptera, Reduviidae) vector of Chagas disease in BoliviaFrederic Lardeux
Institut de Recherche pour le Developpement, Montpellier, France
Trop Med Int Health 15:1037-48. 2010..To define the insecticide resistance status of Triatoma infestans to deltamethrin (pyrethroid), malathion (organophosphate) and bendiocarb (carbamate) in Bolivia...
- Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severityF F de Araújo
Laboratorio de Imunologia Celular e Molecular, Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, Brazil
Immunobiology 217:768-77. 2012Immunoregulatory mechanisms are important to control the intense immune activity induced in Chagas disease. We evaluated the phenotypic profile and the mechanisms by which Treg cells function in patients with the indeterminate (IND) and ..
- Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally infected and non-infected newborns in BoliviaFaustino Torrico
Centro Universitario de Medicina Tropical, Facultad de Medicina, Universidad Mayor de San Simon, Casilla, Cochabamba, Bolivia
Am J Trop Med Hyg 70:201-9. 2004..Neonatal mortality related to congenital Chagas disease also decreased from 13% to 2% in the interval between both studies...
- Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas diseaseMaría Jesús Pinazo
Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
Antimicrob Agents Chemother 57:390-5. 2013For treating Chagas disease (CD), a current worldwide health problem, only benznidazole and nifurtimox have been approved to be used...
- Nested clade and phylogeographic analyses of the Chagas disease vector Triatoma brasiliensis in Northeast BrazilFernando A Monteiro
Departamento de Medicina Tropical, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, Rio de Janeiro, RJ 21045 900, Brazil
Mol Phylogenet Evol 32:46-56. 2004Triatoma brasiliensis (Hemiptera: Reduviidae: Triatominae) is the most important Chagas disease vector in the semiarid areas of Northeast Brazil...
- Vaccine development against Trypanosoma cruzi and Chagas diseaseJuan C Vazquez-Chagoyan
Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Estado de México, Toluca, Mexico
Adv Parasitol 75:121-46. 2011The pathology of Chagas disease presents a complicated and diverse picture in humans...
- Community participation in Chagas disease vector surveillance: systematic reviewFernando Abad-Franch
Instituto Leônidas e Maria Deane Fiocruz Amazônia, Manaus, Brazil
PLoS Negl Trop Dis 5:e1207. 2011Vector control has substantially reduced Chagas disease (ChD) incidence...
- Interactions between intestinal compounds of triatomines and Trypanosoma cruziEloi S Garcia
Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Manguinhos, CEP, Rio de Janeiro, Brazil
Trends Parasitol 26:499-505. 2010Triatomine bugs are vectors of Trypanosoma cruzi, the etiologic agent of Chagas disease, a devastating disease that disables and leads to the death of many people in Latin America...
- Evaluation of spatially targeted strategies to control non-domiciliated Triatoma dimidiata vector of Chagas diseaseCorentin Barbu
UMR 5244 CNRS UPVD EPHE, Biologie et Ecologie Tropicale et Méditerranéenne, Universite de Perpignan Via Domitia, Perpignan, France
PLoS Negl Trop Dis 5:e1045. 2011b>Chagas disease is a major neglected tropical disease with deep socio-economical effects throughout Central and South America...
- Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasionMaria Cecilia Fernandes
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Exp Med 208:909-21. 2011..Thus, T. cruzi subverts the ASM-dependent ceramide-enriched endosomes that function in plasma membrane repair to infect host cells...
- Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infectionMartin S Llewellyn
London School of Hygiene and Tropical Medicine, London, UK
PLoS Pathog 5:e1000410. 2009..The epidemiological significance of these findings is discussed...
- Sex, subdivision, and domestic dispersal of Trypanosoma cruzi lineage I in southern EcuadorSofía Ocaña-Mayorga
Centro de Investigación en Enfermedades Infecciosas, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador
PLoS Negl Trop Dis 4:e915. 2010..We evaluated the molecular diversity of Trypanosoma cruzi, the etiological agent of Chagas disease, in southern Ecuador (Loja Province)...
- Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas diseaseL S Filardi
Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, Brazil
Trans R Soc Trop Med Hyg 81:755-9. 1987The susceptibility and natural resistance to two nitroheterocyclic derivatives used clinically in Chagas disease (nifurtimox and benznidazole) were investigated in 47 Trypanosoma cruzi strains isolated from human patients, domestic ..
- Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybridsMatthew Yeo
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Int J Parasitol 35:225-33. 2005Trypanosoma cruzi, the causative agent of Chagas disease, has at least two principal intraspecific subdivisions, T. cruzi I (TCI) and T. cruzi II (TCII), the latter containing up to five subgroups (a-e)...
- Evaluation and treatment of chagas disease in the United States: a systematic reviewCaryn Bern
Parasitic Diseases Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
JAMA 298:2171-81. 2007..Because of population migration from endemic areas and newly instituted blood bank screening, US clinicians are likely to see an increasing number of patients with suspected or confirmed chronic Trypanosoma cruzi infection (Chagas disease).
- Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusional Chagas disease. Historical aspects, present situation, and perspectivesJoão Carlos Pinto Dias
Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima 1715, 30140 002 Belo Horizonte, MG, Brasil
Mem Inst Oswaldo Cruz 102:11-8. 2007..Brazil, Chile, Paraguay, and Uruguay, the Southern Cone Initiative (SCI) has been extremely important for Chagas disease control in this region...
- The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas diseaseNajib M El-Sayed
Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
Science 309:409-15. 2005....
- Development and validation of a risk score for predicting death in Chagas' heart diseaseAnis Rassi
Division of Cardiology, Anis Rassi Hospital, Goiania, Brazil
N Engl J Med 355:799-808. 2006..Chagas' disease is an important health problem in Latin America, and cardiac involvement is associated with substantial morbidity and mortality. We developed a model to predict the risk of death in patients with Chagas' heart disease...
- The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the futureM A Miles
Pathogen Molecular Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Parasitology 136:1509-28. 2009Trypanosoma cruzi is the protozoan agent of Chagas disease, and the most important parasitic disease in Latin America...
- Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas diseaseSusana A Laucella
Instituto Nacional de Parasitologia Dr Mario Fatala Chaben, Buenos Aires, Argentina
J Infect Dis 189:909-18. 2004..In the majority of patients with Chagas disease, staining with class I major histocompatibility complex tetramers and analysis of interferon (IFN)- gamma ..
- IFN-γ plays a unique role in protection against low virulent Trypanosoma cruzi strainAdele A Rodrigues
Instituto de Ciencias Biomedicas, Universidade Federal de Uberlandia, Uberlandia, Minas Gerais, Brazil
PLoS Negl Trop Dis 6:e1598. 2012..cruzi I) are highly infective in vitro and show no parasitemia in vivo. Here we aimed to understand why amastigotes from G strain are highly infective in vitro and do not contribute for a patent in vivo infection...
- Predicting triatoma dimidiata abundance and infection rate: a risk map for natural transmission of chagas disease in the yucatan peninsula of MexicoEric Dumonteil
Laboratorio de Parasitologia, Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Mexico
Am J Trop Med Hyg 70:514-9. 2004b>Chagas disease, a major public health problem in Latin America, is caused by the protozoan parasite Trypanosoma cruzi and transmitted by hematophageous insects from the Triatominae subfamily...
- Chagas disease: assessing the existence of a threshold for bug infestation rateHirotsugu Aiga
Human Development Department, Japan International Cooperation Agency JICA, Tokyo, Japan
Am J Trop Med Hyg 86:972-9. 2012..rate of Triatoma dimidiata, below which transmission becomes unlikely, a census was conducted in 59 Chagas disease endemic communities of El Salvador and Honduras...
- Sterol 14-demethylase inhibitors for Trypanosoma cruzi infectionsFrederick S Buckner
Department of Medicine, University of Washington, Seattle, Washington, USA
Adv Exp Med Biol 625:61-80. 2008b>Chagas disease is caused by infection with the protozoan pathogen, Trypanosoma cruzi...
- Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas diseaseL Lopez
Instituto de Biologia, Universidad de Antioquia, Calle 67 No 53 108, Medellin, Colombia
Insect Biochem Mol Biol 33:439-47. 2003..associated with innate immunity in insects was isolated from the hemolymph of Rhodnius prolixus, a vector of Chagas disease. This peptide, designated R. prolixus defensin A, was purified and sequenced...
- Parasitic diseases of the heartLouis V Kirchhoff
Departments of Internal Medicine Infectious Diseases and Epidemiology, University of Iowa, Iowa City, USA
Front Biosci 9:706-23. 2004..The larval forms of the tapeworms Echinococcus and Taenia solium may cause space-occupying lesions of the heart. Severe infection with the nematode Trichinella spiralis may cause myocarditis...
- Identification of a large hybrid zone between sympatric sibling species of Triatoma dimidiata in the Yucatan peninsula, Mexico, and its epidemiological importanceMelba Herrera-Aguilar
Laboratorio de Parasitologia, Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico
Infect Genet Evol 9:1345-51. 2009Triatoma dimidiata is one of the major Chagas disease vectors, with an extensive diversity in its morphology, habitat, and level of domiciliation...
- [Updated geographical distribution and ecoepidemiology of the triatomine fauna (Reduviidae: Triatominae) in Colombia]Felipe Guhl
Centro de Investigaciones en Microbiologia y Parasitologia Tropical, Facultad de Ciencias, Universidad de Los Andes, Bogota, Colombia
Biomedica 27:143-62. 2007..Entomological surveillance providess a necessary tool to reinforce the control strategies for Chagas disease. This also allows the evaluation of transmission risk that the sylvatic triatomines represent in Colombia.
- Dispersal of Triatoma infestans and other Triatominae species in the arid Chaco of Argentina: flying, walking or passive carriage? The importance of walking femalesLuciana Beatriz Abrahan
Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja, Anillaco, La Rioja, Argentina
Mem Inst Oswaldo Cruz 106:232-9. 2011..However, manual inspection of 122 chickens suggests that it is unlikely that these animals passively transport T. infestans. Finally, the dispersal activity of T. infestans was compared with other triatomines using a dispersion index...
- Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/"indeterminate" and Chagas disease cardiomyopathy patientsRenata Cristina Ferreira
Divisão de Cardiopatias Gerais, Instituto do Coracao, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, 05403 000, Brasil
Mem Inst Oswaldo Cruz 98:407-11. 2003We compared plasma tumor necrosis factor-alpha (TNF-alpha) levels among asymptomatic/"indeterminate" Chagas disease patients (ASY) and patients across the clinical spectrum of chronic Chagas disease cardiomyopathy (CCC)...
- Tolerance and safety of nifurtimox in patients with chronic chagas diseaseYves Jackson
Divisionof Primary Care Medicine, Department of Community Medicine and Primary Care, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Clin Infect Dis 51:e69-75. 2010Nifurtimox has been used to treat Chagas disease for 40 years, but tolerance and safety data in adults are scarce...
- Congenital Chagas disease: estimating the potential risk in the United StatesZaida E Yadon
Health Surveillance, Disease Prevention and Control, Pan American Health Organization, Washington, DC 20037 2895, USA
Am J Trop Med Hyg 81:927-33. 2009..cruzi-infected population from Latin American countries to the United States and Europe; originating cases of Chagas disease were transmitted through blood, organ donation, and vertical transmission...
- Unexpected failures to control Chagas Disease vectors with pyrethroid spraying in northern ArgentinaJuan M Gurevitz
Department of Ecology, Genetics and Evolution, Universidad de Buenos Aires, Ciudad Universitaria, Argentina
J Med Entomol 49:1379-86. 2012..Our results underline the need for close monitoring of the impact of insecticide spraying to provide early warning of possible problems because of enhanced resistance or tolerance and determine appropriate responses...
- Oxidative damage during chagasic cardiomyopathy development: role of mitochondrial oxidant release and inefficient antioxidant defenseJian Jun Wen
Department of Microbiology and Immunology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA
Free Radic Biol Med 37:1821-33. 2004....
- A role for extracellular amastigotes in the immunopathology of Chagas diseaseJ Scharfstein
Laboratório de Imunologia Molecular, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
Mem Inst Oswaldo Cruz 94:51-63. 1999..of Trypanosoma cruzi infection, the mechanisms responsible for the variable clinico-pathological expression of Chagas disease remain unknown...
- Recent, independent and anthropogenic origins of Trypanosoma cruzi hybridsMichael D Lewis
Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Negl Trop Dis 5:e1363. 2011..Trypanosoma cruzi, a parasite transmitted by numerous species of triatomine bug in the Americas, causes Chagas disease in humans. T. cruzi generally reproduces asexually and appears to have a clonal population structure...
- Analyses of 32 loci clarify phylogenetic relationships among Trypanosoma cruzi lineages and support a single hybridization prior to human contactCarlos A Flores-López
Department of Biology, University of Maryland, College Park, MD, USA
PLoS Negl Trop Dis 5:e1272. 2011The genetic diversity of Trypanosoma cruzi, the etiological agent of Chagas disease, has been traditionally divided in two major groups, T...
- Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patientsJian Jun Wen
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
Free Radic Biol Med 41:270-6. 2006..oxidative damage and mitochondrial functional decline and might be of pathological significance in Chagas disease. In the present study, we investigated whether enhanced oxidative stress and mitochondrial functional decline ..
- Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992-2007Ezequiel Cordova
Francisco J Muñiz Infectious Diseases Hospital, Uspallata 2262, Buenos Aires, Argentina
Int J Infect Dis 12:587-92. 2008The objective of this study was to evaluate clinical and microbiological characteristics of Chagas disease (ChD) with central nervous system (CNS) involvement in AIDS patients.
- Fighting the oxidative assault: the Trypanosoma cruzi journey to infectionLucia Piacenza
Departamento de Bioquimica, Facultad de Medicina, Universidad de la Republica, Montevideo Uruguay, Uruguay
Curr Opin Microbiol 12:415-21. 2009..parasites more prepared to deal with the host-oxidative assault are more efficient for the establishment of Chagas disease. For instance, parasites overexpressing peroxiredoxins are more resistant to macrophage-derived peroxynitrite, ..
- Genetic transformation of a Corynebacterial symbiont from the Chagas disease vector Triatoma infestansRavi V Durvasula
Department of Internal Medicine, University of New Mexico, 915 Camino Del Salud NE, CRF 305, Albuquerque, NM 87131, USA
Exp Parasitol 119:94-8. 2008..Previously, we developed paratransgenic lines of Rhodnius prolixus, a vector of Chagas disease in Central America...
- Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trialRodolfo Viotti
Hospital Interzonal General de Agudos Eva Perón and Instituto Nacional de Parasitología Dr Mario Fatala Chaben, Buenos Aires, Argentina
Ann Intern Med 144:724-34. 2006Benznidazole is effective for treating acute-stage Chagas disease, but its effectiveness for treating indeterminate and chronic stages remains uncertain.
- Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infectionAndre Bafica
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 177:3515-9. 2006..Our results reveal that TLR2 and TLR9 cooperate in the control of parasite replication and that TLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-gamma synthesis during infection with T. cruzi...
- Sustainability of vector control strategies in the Gran Chaco Region: current challenges and possible approachesRicardo E Gürtler
Laboratory of Eco Epidemiology, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Mem Inst Oswaldo Cruz 104:52-9. 2009..b>Chagas disease control programs traditionally have been composed of two divorced entities: a vector control program in charge ..
- Ergosterol biosynthesis and drug development for Chagas diseaseJulio A Urbina
Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Mem Inst Oswaldo Cruz 104:311-8. 2009..drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis ..
- Pathogenesis of chagas' disease: parasite persistence and autoimmunityAntonio R L Teixeira
Chagas Disease Multidisciplinary Research Laboratory, University of Brasilia, Federal District, Brazil
Clin Microbiol Rev 24:592-630. 2011..These results suggest that the inflammatory cardiomyopathy of Chagas' disease is a genetically driven autoimmune disease...
- Genetics and evolution of triatomines: from phylogeny to vector controlS Gourbiere
UMR 5244 CNRS UPVD Ecologie et Evolution des Interactions, Universite de Perpignan Via Domitia, Perpignan, France
Heredity (Edinb) 108:190-202. 2012..This parasite causes Chagas disease, one of the major parasitic diseases in the Americas...
- Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptorsJ Scharfstein
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CEP 21990 400 Rio de Janeiro, Brazil
J Exp Med 192:1289-300. 2000..Analysis of trypomastigote transfectants expressing various cysteine proteinase isoforms showed that invasion competence is linked to the kinin releasing activity of cruzipain, herein proposed as a factor of virulence in Chagas' disease...
- Predominance of lineage I among Trypanosoma cruzi isolates from Venezuelan patients with different clinical profiles of acute Chagas' diseaseNéstor Añez
Departamento de Biologia, Universidad de Los Andes, Facultad de Ciencias, Merida, Venezuela
Trop Med Int Health 9:1319-26. 2004..cruzi I infection to humans. To our knowledge, this is the first study describing predominance of T. cruzi lineage I in a large number of acute chagasic patients with distinct and well-characterized clinical profiles...
- Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas, VenezuelaBelkisyolé Alarcón de Noya
Departments of Immunology, Instituto de Medicina Tropical, Universidad Central de Venezuela Código Postal 1041, Los Chaguaramos, Caracas, Venezuela
J Infect Dis 201:1308-15. 2010Trypanosoma cruzi oral transmission is possible through food contamination by vector's feces. Little is known about the epidemiology and clinical features of microepidemics of orally acquired acute Chagas disease (CD).
- Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmissionArlei Marcili
Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
Int J Parasitol 39:615-23. 2009..13 TCI and nine TCIIa), and humans with Chagas disease associated with oral transmission (14 TCI and five TCIIa) in Brazilian Amazonia...
- The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas diseaseCaroline Junqueira
Laboratorio de Immunopatologia, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, MG, Brazil
Expert Rev Mol Med 12:e29. 2010Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is characterised by a variable clinical course - from symptomless cases to severe chronic disease with cardiac and/or gastrointestinal involvement...
- Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophagesC G Freire-de-Lima
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, RJ, Brazil
Nature 403:199-203. 2000....
- Periurban Trypanosoma cruzi-infected Triatoma infestans, Arequipa, PeruMichael Zachary Levy
Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Emerg Infect Dis 12:1345-52. 2006In Arequipa, Peru, vectorborne transmission of Chagas disease by Triatoma infestans has become an urban problem...
- Chagas disease: what is known and what is needed--a background articleJosé Rodrigues Coura
Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, 21045 900, Brasil
Mem Inst Oswaldo Cruz 102:113-22. 2007b>Chagas disease began millions of years ago as an enzootic disease of wild animals and started to be transmitted to man accidentally in the form of an anthropozoonosis when man invaded wild ecotopes...
- Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infectionV Michailowsky
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil
Am J Pathol 159:1723-33. 2001..cruzi. Thus, our results suggest that the level of IFN-gamma deficiency is a major determinant of the site of reactivation of T. cruzi infection in immunocompromised host...
- Development of a real-time PCR assay for Trypanosoma cruzi detection in blood samplesMaria Piron
Transfusion Safety Laboratory, Banc de Sang i Teixits, Barcelona, Spain
Acta Trop 103:195-200. 2007..Concordance of results with the N-PCR was 90%. In conclusion, real-time PCR provides an optimal alternative to N-PCR, with similar sensitivity and higher throughput, and could help determine ongoing parasitaemia in chagasic patients...
- CD8+ T cells in Trypanosoma cruzi infectionAngel M Padilla
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
Curr Opin Immunol 21:385-90. 2009..players in the control of a number of protozoan pathogens, including Trypanosoma cruzi, the agent of human Chagas disease. The recent identification of the dominant targets of T...
- Accurate real-time PCR strategy for monitoring bloodstream parasitic loads in chagas disease patientsTomas Duffy
Laboratorio de Biologia Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular INGEBI CONICET, Buenos Aires, Argentina
PLoS Negl Trop Dis 3:e419. 2009This report describes a real-time PCR (Q-PCR) strategy to quantify Trypanosoma cruzi (T. cruzi) DNA in peripheral blood samples from Chagas disease patients targeted to conserved motifs within the repetitive satellite sequence.
- Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccinationBruna C G de Alencar
Centro Interdisciplinar de Terapia Gênica CINTERGEN, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Mirassol 207, Sao Paulo, SP 04044 010, Brazil
Infect Immun 77:4383-95. 2009..Our study thus demonstrated a role for perforin and IFN-gamma in a number of T-cell-mediated effector functions and in the antiparasitic immunity generated by a heterologous plasmid DNA prime-adenovirus boost vaccination strategy...
- Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infectionJ C Engel
Department of Pathology, University of California San Francisco, California 94143, USA
J Exp Med 188:725-34. 1998..No abnormalities were noted in the Golgi complex of host cells. This study provides proof of concept that cysteine protease inhibitors can be given at therapeutic doses to animals to selectively arrest a parasitic infection...
- Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infectionJ C Aliberti
Departments of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Av Bandeirantes, 3900, 14 049 900, Ribeirao Preto, Sao Paulo, Brazil
Am J Pathol 158:1433-40. 2001..cruzi infection and mediate resistance to infection...
- Chemokines, inflammation and Trypanosoma cruzi infectionMauro M Teixeira
Departmento Bioquímica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Pampulha, 31270 901, Belo Horizonte, MG, Brazil
Trends Parasitol 18:262-5. 2002..is essential for host resistance to infection but is also responsible for the diverse pathology observed in Chagas disease. Here, we examine the stimuli and mechanisms underlying chemokine production following infection in vitro and ..
- Genetic susceptibility to chronic Chagas disease: an overview of single nucleotide polymorphisms of cytokine genesRomero H T Vasconcelos
Department of Immunology, Centro de Pesquisas Aggeu Magalhaes, Recife, Brazil
Cytokine 59:203-8. 2012b>Chagas disease is a parasitic infection that is a significant public health problem in Latin America...
- Hidden sylvatic foci of the main vector of Chagas disease Triatoma infestans: threats to the vector elimination campaign?Leonardo A Ceballos
Laboratory of Eco Epidemiology, Department of Ecology, Genetics and Evolution, Universidad de Buenos Aires, Buenos Aires, Argentina
PLoS Negl Trop Dis 5:e1365. 2011....
- Pre-Columbian Chagas disease in Brazil: Trypanosoma cruzi I in the archaeological remains of a human in Peruaçu Valley, Minas Gerais, BrazilAlexandre Fernandes
Laboratório de Genética Molecular de Microorganismos, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brasil
Mem Inst Oswaldo Cruz 103:514-6. 2008..cruzi I genotype. This finding suggests that T. cruzi I infected humans during the pre-Columbian times and that, in addition to T. cruzi infection, Chagas disease in Brazil most likely preceded European colonization.
- Update in treatment of Chagas diseaseGuillaume Le Loup
Service des Maladies Infectieuse et Tropicales, Hôpitaux Universitaires Paris Est Tenon, AP HP, Universite Pierre et Marie Curie, Paris, France
Curr Opin Infect Dis 24:428-34. 2011This review discusses the recent data about the pathogenesis of Chagas disease, tolerance of drugs, and follow-up of patients impacting the treatment of Chagas disease in immunocompetent and immunocompromised patients.
- Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysisJosé A Pérez-Molina
Tropical Medicine Unit, Infectious Diseases Department, Hospital Ramon y Cajal, Madrid, Spain
J Antimicrob Chemother 64:1139-47. 2009..Our objectives were to evaluate published evidence on the treatment of chronic Chagas' disease with benznidazole and on the potential benefits of this drug in the chronic phase of the disease...
- Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas diseaseMargoth Moreno
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
Mem Inst Oswaldo Cruz 105:918-24. 2010Therapeutic failure of benznidazole (BZ) is widely documented in Chagas disease and has been primarily associated with variations in the drug susceptibility of Trypanosoma cruzi strains...
- ELISA versus PCR for diagnosis of chronic Chagas disease: systematic review and meta-analysisPedro E A A Brasil
Instituto de Pesquisa Clínica Evandro Chagas Fundação Oswaldo Cruz, Rio de Janeiro RJ, Brazil
BMC Infect Dis 10:337. 2010Most current guidelines recommend two serological tests to diagnose chronic Chagas disease. When serological tests are persistently inconclusive, some guidelines recommend molecular tests...
- Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in miceKara L Cummings
Center for Tropical and Emerging Global Diseases, 623 Biological Sciences Building, University of Georgia, Athens, GA 30602, USA
Infect Immun 72:4081-9. 2004..These results clearly show that iNOS is not required for control of T. cruzi infection in mice...
- Killed But Metabolically Active Leishmania: a novel protozoan vaccine technologyNoah Craft; Fiscal Year: 2009..If effective, this technology could potentially be applied to other infectious agents such as malaria and tuberculosis in the future. ..
- Pathogenesis of Oxidative Stress in Chagas DiseaseNisha Jain Garg; Fiscal Year: 2013DESCRIPTION (provided by applicant): Chagas disease is caused by the protozoan Trypanosoma cruzi, and represents the third greatest tropical disease burden globally...
- Role of Lipoproteins in Chagasic heart diseaseJYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013DESCRIPTION (provided by applicant): Chagas disease, caused by an intracellular parasite Trypanosoma cruzi, is a major public health problem with significant social and economic implications in most Latin American countries and among ..
- Mitochondrial Biomarkers of Cardiomyopathy and Cure in Chagas DiseaseNisha Jain Garg; Fiscal Year: 2013..gt;300,000 patients in the US and >10 million patients in endemic countries, and total annual cost of Chagas disease management is estimated at >8 billion US dollars...
- Rational Development of Anti-Trypanosoma Cruzi DrugsMichael H Gelb; Fiscal Year: 2013..of the proposed research is to develop inhibitors of the sterol 14a-demethylase (14DM) enzyme for treating Chagas disease. Trypanosoma cruzi, the etiologic agent of Chagas disease, is widespread in Latin America and causes ..
- K777 for treatment of Chagas Disease: IND-enabling Studies and IND SubmissionRobert Don; Fiscal Year: 2012DESCRIPTION (provided by applicant): Chagas disease remains a major health problem in Latin America due to lack of an effective preventative vaccine and inadequate treatments post-infection...
- Role of mucin-type O-glycosylation in Trypanosoma cruzi biologyChristopher M West; Fiscal Year: 2012DESCRIPTION (provided by applicant): Trypanosoma cruzi is a single-cell protozoan parasite that causes Chagas disease, characterized by cardiac or gastrointestinal complications in chronically infected patients...
- Olfactory and behavioral responses of kissing bugs (Reduviidae: Triatominae), vecJohn G Hildebrand; Fiscal Year: 2010..are blood-sucking insects, vectors of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas Disease. This Disease is endemic in Mexico, Central and South America and affects about 11-13 million people...
- FUNCTION OF THE KINETOPLAST IN THE HEMOFLAGELLATESLarry Simpson; Fiscal Year: 2013..significance is that these parasites are the causal agents of a number of important human diseases including Chagas Disease, Leishmaniasis and African Sleeping Sickness, and that the editing pathway is essential in all stages of the ..
- Geographically robust rapid assay for T. cruzi infectionSYAMAL X RAYCHAUDHURI; Fiscal Year: 2010..is transmitted via blood transfusions, is prevalent in Latin America, and is the causative agent for fatal chagas disease. Positive blood donors have been identified, and transmission via the insect vector has been reported in the ..
- Synthesis of immunogenic glycolipopeptides for the development of vaccines for ChKatja Michael; Fiscal Year: 2010DESCRIPTION (provided by applicant): Trypanosoma cruzi is a protozoan parasite that causes Chagas disease in Central America...
- Chagas Disease Confirmatory AssayAndrew Levin; Fiscal Year: 2009..PUBLIC HEALTH RELEVANCE Chagas disease has become a significant threat to public health and to the blood supply, both in the U.S...
- Human serum carbonyl proteome in cardiovascular diseasesNisha Jain Garg; Fiscal Year: 2010..74 million disability-adjusted life years per year. By the time most patients are diagnosed with Chagas disease, heart dysfunction has been progressing for many years...
- Validation and development of trypanosomal phosphodiesterase inhibitors for treatMichael P Pollastri; Fiscal Year: 2013..cruzi (which causes Chagas disease) have been recently elucidated, a number of potentially therapeutically-relevant molecular targets have been ..
- Confirmatory Immunoblot Test for Chagas'DiseaseANDREW E LEVIN; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: Chagas disease has become a significant threat to public health and to the blood supply, both in the U.S...
- Global sumoylation analysis in Trypanosoma bruceiDavid A Campbell; Fiscal Year: 2010..of medical importance, including the causative agents of human leishmaniasis, African trypanosomiasis and Chagas disease. These organisms employ an unusual mechanism of gene expression that involves polycistronic transcription of ..
- Pathogenesis of Trypanosoma cruzi infectionRoberto Docampo; Fiscal Year: 2013DESCRIPTION (provided by applicant): Morbidity and mortality associated with Chagas disease in Latin America exceed better-known conditions such as malaria, tuberculosis, or AIDS. Millions of people are affected by this trypanosomiasis...
- ETIOLOGY AND PATHOGENESIS OF PEMPHIGUSLuis A Diaz; Fiscal Year: 2013..Moreover, the sera of patients with leishmaniasis, Chagas disease and onchocerciasis, where these insects are involved as carriers of parasites, possess anti-Dsg1 antibodies...
- Tulane-Xavier Minority Training in International HealthRichard A Oberhelman; Fiscal Year: 2013..tuberculosis in Peru, interventions to reduce maternal and perinatal morbidity and mortality in Argentina, Chagas disease in Mexico, clinical trials of new antimalarial drugs in Mali, Lassa Fever and tropical diseases in Sierra ..
- Broad Detection of Infectious Agents in Blood by Microarrays and Deep SequencingCHARLES YEN CHIU; Fiscal Year: 2013..accuracy) for detection of pathogens associated with the most common bloodborne infections, including malaria, Chagas disease, HIV, hepatitis B/C, and dengue virus...
- Ultraviolet light sensing by cryptochromeTodd C Holmes; Fiscal Year: 2013..Other CRY sequences will become available in the near future for testing the insect vectors for Chagas disease and typhus...
- Characterization of Potassium Channels in the Human Parasite Trypanosoma CruziVeronica Jimenez; Fiscal Year: 2012DESCRIPTION (provided by applicant): Chagas disease is a zoonotic tropical pathology, caused by the protozoan parasite Trypanosoma cruzi. Endemic in Latin America, it is one of the leading causes of congestive heart failure in the world...
- Trypanosoma cruzi Antioxidant Systems, Virulence and Parasite Persistence in ChagRafael Radi; Fiscal Year: 2013DESCRIPTION (provided by applicant): Chagas disease caused by the parasitic protozoan Trypanosoma cruzi remains a major public health concern in Latin America and is now spreading worldwide...
- Improving blood safety and HIV testing in Brazil: a randomized controlled trialTHELMA THEREZINHA GONCALEZ; Fiscal Year: 2013..include differences in prevalence of transfusion-transmitted infections (HIV, HCV, HBV, syphilis, HTLV I/II, Chagas disease), donor motivations (e.g., test-seeking vs...
- Deep sequence profiling of gRNA transcriptomes in two stages of Trypanosoma bruceDONNA JAY KOSLOWSKY; Fiscal Year: 2012..diseases targeted for attention by the World Health Organization (WHO);Leishmaniasis, sleeping sickness and Chagas disease. Together these parasites affect approximately 550 million people in the developing world...
- Space Renovation for New Research Center for the Neglected Diseases of PovertyJohn Williams; Fiscal Year: 2010..Also, extensive research is underway to study the major U.S. NIPs including toxocariasis, toxoplasmosis, and Chagas disease, currently affecting millions of African Americans and Hispanic Americans...
- Early Detection of Congenital Chagas DiseaseRobert H Gilman; Fiscal Year: 2013..Approximately 5% of T. cruzi infected women give birth to infected infants at risk of clinically manifest Chagas disease at birth, shortly after birth or later in life...
- Global gene expression analysis of Trypanosoma cruzi under hyperosmotic stressRoberto Docampo; Fiscal Year: 2012..Juan J. Cazzulo, as an extension of NIH Grant 1R01 AI068647. Chemotherapy of Chagas disease is restricted to drugs with relatively high toxicity and limited efficacy...
- Testing DNA Vaccine Against T. cruzi in Large Animal Model (Dogs)Nisha Jain Garg; Fiscal Year: 2010SUMMARY The protozoan parasite T. cruzi-induced Chagas disease is the prime cause of death in young adults in endemic areas of the American continent and results in >50,000 deaths, 1 million new cases, and loss of 2...
- Structural Requirements for Sterol 14alpha-DemethylasesGalina I Lepesheva; Fiscal Year: 2013..four test systems: protozoa themselves, human cells, human cells infected with protozoa and mouse models for Chagas disease. Second, we will test these scaffolds and their derivatives as potential drugs for treatment of infection by ..
- Mechanistic and structural studies of eukaryotic UDP-galactopyranose mutasesPablo Sobrado; Fiscal Year: 2013..for the development of chemotherapeutics for the treatment of fungal infections and neglected diseases such as Chagas disease. ) PUBLIC HEALTH RELEVANCE: UDP-galactopyranose mutase (UGM) catalyzes a key step in the biosynthesis of ..
- CHADSS: Chagas Disease Scan StudyJamary Oliveira-Filho; Fiscal Year: 2013..One of the main contributors to stroke incidence is the highly prevalent Chagas disease, a parasitic infection affecting an estimated 18 million individuals and a major cause of heart failure in ..
- Kinetoplastid SL RNA biogenesisDavid A Campbell; Fiscal Year: 2013..which includes the parasitic protozoa responsible for leishmaniasis, African Sleeping Sickness, and Chagas Disease. The focus is on the genesis and function of the spliced leader (SL) RNA, a small RNA that contributes the 5&..
- Characterization of Potassium Channels in the Human Parasite Trypanosoma CruziVeronica Jimenez; Fiscal Year: 2013Abstract Chagas disease is a zoonotic tropical pathology, caused by the protozoan parasite Trypanosoma cruzi. Endemic en Latin America, it is one of the leading causes of congestive heart failure in the world...
- Xenodiagnosis of Lyme DiseaseLinden T Hu; Fiscal Year: 2012..Xenodiagnosis has been used for other difficult to diagnose diseases such as Chagas disease. Organisms may be specifically adapted to their natural vector and xenodiagnosis can sometimes definitively ..
- HTS assay for the intracellular stages of T. cruzi, the vector of Chagas diseaseJuan Engel; Fiscal Year: 2009..cruzi, and to screen compound libraries from industrial and academic sources. This HTS assay will greatly facilitate drug discovery efforts for Chagas'disease. ..
- Structures and selective inhibition of tRNA synthetases from pathogenic protozoaWILHELMUS HOL; Fiscal Year: 2009..These are related parasites which cause sleeping sickness, Chagas disease, and leishmaniasis, respectively, and are responsible for millions of infections and nearly one million deaths ..
- Selective inhibition of tRNA synthetases from pathogenic protozoaWILHELMUS G J HOL; Fiscal Year: 2013..These are related parasites which cause sleeping sickness, Chagas disease, and leishmaniasis, respectively, and are responsible for tens of millions of infections annually, mainly in ..
- STRUCTURE AND MECHANISM OF PROTEIN PRENYLTRANSFERASESLorena S Beese; Fiscal Year: 2013..and GGTase inhibitors (FTls and GGTIs) show promise for treatment of parasitics infections including malaria, Chagas disease, African sleeping sickness, Leishmania and fungal infections such as Candida albicans, which can be life-..
- Broad spectrum antivirals targeting envelope proteolysis and viral uncoatingGraham Simmons; Fiscal Year: 2013..lead compounds, one of which is being developed by members of our consortium as a therapeutic agent for Chagas disease. We propose to refine these compounds in order to increase their drug-like properties and optimize their ..
- Training in Tropical and Emerging Global DiseasesBoris Striepen; Fiscal Year: 2013..The research systems available for study include malaria, intestinal protozoans, Chagas disease, African sleeping sickness, leishmaniasis, toxoplasmosis, Ichthyophthirius multifiliis, schistosomiasis, ..
- 2010 Biology of Host-Parasite Interactions Gordon Research ConferenceL David Sibley; Fiscal Year: 2010..The focus will be on the identification, validation, and characterization of new therapeutic targets and strategies to combat human infectious diseases. ..
- Validating novel drug targets in Trypanosoma cruzi polyamine biosynthesisMichael C Gretes; Fiscal Year: 2013DESCRIPTION (provided by applicant): Trypanosoma cruzi is the protozoan trypanosomatid parasite that causes Chagas disease, which affects 10-12 million overwhelmingly poor people in 22 Latin American countries and an estimated 300,000 in ..
- New molecular techniques for T. cruziHuan Huang; Fiscal Year: 2013DESCRIPTION (provided by applicant): Trypanosoma cruzi (T. cruzi) causes Chagas Disease (e.g., American Trypanosomiasis) in humans...
- The ecology and epidemiology of Chagas disease in urban and rural communitiesCESAR GABRIEL NAQUIRA; Fiscal Year: 2011..of vectors and parasite into the city of Arequipa itself allows analysis of the trend of urbanization of Chagas disease transmission and identification of modifications necessary to eliminate the vector from the urban environment...
- Role of DNA Ligands in Innate ImmunityNilay Dey; Fiscal Year: 2013DESCRIPTION (provided by applicant): Chagas disease (CHD) caused by Trypanosoma cruzi (T. cruzi) is endemic in Latin America and an emerging disease in the US and other developed countries. The overall prevalence of human T...
- Oxidative Response Networks in Chagasic CardiomyopathyNisha Jain Garg; Fiscal Year: 2013..we plan to investigate the critical importance of mitochondrial dysfunction and oxidative stress in human Chagas disease severity. Our central hypothesis is that infection by T...
- Ultrahigh Resolution Optical BarcodeROBERT C HAUSHALTER; Fiscal Year: 2011..along with the MARS, and (5) test the completely functional system by comparing our diagnostic assay for Chagas disease against a known diagnostic assay using Luminex...
- Transmission-blocking live vaccine for Chagas diseaseRick L Tarleton; Fiscal Year: 2013..Additionally, such a vaccine could be delivered in an oral form - making widespread vaccination of animals quite easy. ..
- Sterol Biosynthesis in Trypanosomatid ParasitesFrederick Buckner; Fiscal Year: 2004The long-term objective of this project is to discover new therapeutics for leishmaniasis and Chagas disease. These infectious diseases are caused by parasitic protozoa of the family, Trypanoisomatidae...
- Structure-Aided Design of CYP51 Inhibitors for Treatment of Parasitic InfectionsLarissa M Podust; Fiscal Year: 2013..that target the sterol biosynthesis pathway in Trypanosoma cruzi, agent of the neglected tropical disease Chagas Disease. No vaccine exists for this infection nor is one likely to become available any time soon...
- Exploiting the cAMP pathway in Chagas Disease TherapyDaniel L Altschuler; Fiscal Year: 2013..e. Chagas disease. Chagas disease is a life-threatening illness caused by the protozoan parasite Trypanosoma cruzi...
- Regional Training Center for Tropical Disease Research in Quito-EcuadorMario J Grijalva; Fiscal Year: 2013..overall objective of this proposal is to obtain biological and clinical information that will improve current Chagas disease control efforts in Ecuador, while implementing a sound and sustainable training program in infectious disease ..
- Genetic Epidemiology of Chagas Disease ProgressionSARAH A WILLIAMS-BLANGERO; Fiscal Year: 2012b>Chagas disease affects 17 million people and a further 100 million people are at risk for infection with Trypanosoma cruzi, the parasitic cause of Chagas disease, throughout Latin America...
- T. cruzi molecular targets for vector paratransgenesisRavi V Durvasula; Fiscal Year: 2010b>Chagas disease afflicts over 12 million people in Central and South America...
- Lead Identification to Clinical Candidate Selection: Drugs for Chagas DiseaseJames H McKerrow; Fiscal Year: 2013....
- GENETIC ANALYSIS OF PURINE METABOLISM IN LEISHMANIA DONOBuddy Ullman; Fiscal Year: 2007..coli that overexpress hgprt genes, and[unreadable] intact parasites. ..
- Identification and Validation of Targets of Phenotypic High Throughput ScreeningSean Ekins; Fiscal Year: 2013..by applicant): Identification and Validation of Targets of Phenotypic High Throughput Screening Hits for Chagas Disease Project Summary Nearly 10 million people in Latin America are infected with the eukaryotic parasite ..
- STRUCTURE AND SYNTHESIS OF DNARobert E Jensen; Fiscal Year: 2013..study is Trypanosoma brucei that causes African sleeping sickness, although related parasites with kDNA cause Chagas disease and Leishmaniasis...
- Mathematical Techniques for Control of Epidemic Trypanosoma cruzi TransmissionMichael Zachary Levy; Fiscal Year: 2012b>Chagas disease, caused by the unicellular parasite Trypanosoma cruzi, is a preventable disease. Nevertheless more people in the Americas die from Chagas disease than any other parasitic infection...
- Sao Paulo- MInas Gerais Neglected Tropical Disease Research Center for BiomarkerEster Cerdeira Sabino; Fiscal Year: 2013..of the Public Health System in the State of Minas by enrolling and collecting blood samples from 2000 Chagas disease patients...
- Interhemispheric Research/Training in Infectious DiseaseHERBERT BERNARD TANOWITZ; Fiscal Year: 2013..e., histoplasmosis, sporotrichosis) parasitic diseases (Chagas disease, toxoplasmosis and malaria) and bacterial diseases (legionnaire's disease and tuberculosis) which are ..
- Development of T cell memory in human Trypanosoma cruzi infectionSusana Laucella; Fiscal Year: 2013..The frequencies of T. cruzi-specific T cells were also found to correlate with the severity of chronic Chagas disease. Based upon these results, it may be hypothesized that in the face of the persistence of stimulating antigen ..
- GUIDE: Genomic Uses in Infectious Diseases and EpidemicsJeffrey P Kahn; Fiscal Year: 2013..g., HIV, HPV, tuberculosis), and broaden our reach to include additional categories of infectious disease such as insect-borne (e.g., malaria, Dengue fever, Chagas disease) and, perhaps, food-borne infections.
- Chemokine-endothelin interaction & Chagas' diseaseHerbert Tanowitz; Fiscal Year: 2006..The research will be performed primarily at the Brazil site in collaboration with Herbert Tanowitz at the US site as extension of NIH Grant AI-12770 [unreadable] [unreadable]..
- MUTATIONAL ANALYSIS OF A PARASITE PURINE SALVAGE ENZYMESYDNEY CRAIG; Fiscal Year: 2001..abstract_text> ..
- ROLE OF CALRETICULIN IN CALCIUM HOMEOSTASIS OF T. CRUZIRoberto Docampo; Fiscal Year: 2002..Our specific aims are: specific aim 1, to investigate the levels and location of calreticulin in T. cruzi different stages, and specific aim 2, to investigate the role of calreticulin in Ca2+ homeostasis in T. cruzi ..
- Development of Dynamic Combinatorial Libraries for Cruzipain InhibitionPeter Wipf; Fiscal Year: 2009..2. Identify compounds with biological significance for Chagas disease: (a) test the libraries using the enzyme cruzipain in order to identify inhibitors by changes in the library ..
- ACIDOCALCISOMES IN TRYPANOSOMA CRUZIRoberto Docampo; Fiscal Year: 2002..cruzi H+-pyrophosphatase; specific aim 3: investigation of the role of acidocalcisomes in intracellular Ca2+ and pH homeostasis. ..