chagas disease

Summary

Summary: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.

Top Publications

  1. ncbi Chagas disease
    Anis Rassi
    Division of Cardiology, Anis Rassi Hospital, Goiania, GO, Brazil
    Lancet 375:1388-402. 2010
  2. ncbi The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications
    Bianca Zingales
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Avenida Professor Lineu Prestes 748, 05508 000 Sao Paulo, SP, Brazil
    Infect Genet Evol 12:240-53. 2012
  3. ncbi Chagas disease: a Latin American health problem becoming a world health problem
    Gabriel A Schmunis
    Health Surveillance, Disease Prevention and Control, Pan American Health Organization, Regional Office of the World Health Organization, 525 23th Street N W, Washington, DC 20037, USA
    Acta Trop 115:14-21. 2010
  4. pmc Global economic burden of Chagas disease: a computational simulation model
    Bruce Y Lee
    Public Health Computational and Operations Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Lancet Infect Dis 13:342-8. 2013
  5. ncbi American trypanosomiasis (Chagas disease)
    Anis Rassi
    Division of Cardiology, Anis Rassi Hospital, Avenida José Alves 453, Setor Oeste, Goiania, GO 74110 020, Brazil
    Infect Dis Clin North Am 26:275-91. 2012
  6. pmc The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
    PLoS Negl Trop Dis 2:e300. 2008
  7. pmc Mechanisms of Trypanosoma cruzi persistence in Chagas disease
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 14:634-43. 2012
  8. ncbi Chagas disease in Spain, the United States and other non-endemic countries
    Joaquim Gascon
    Centre de Salut Internacional, CRESIB, Hospital Clinic, IDIBAPS, C Villarroel, 170, 08036, Barcelona, Spain
    Acta Trop 115:22-7. 2010
  9. ncbi Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy
    Alvaro Moncayo
    Academia Nacional de Medicina, Bogota, Colombia
    Mem Inst Oswaldo Cruz 104:17-30. 2009
  10. ncbi Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches
    Julio A Urbina
    Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Acta Trop 115:55-68. 2010

Detail Information

Publications411 found, 100 shown here

  1. ncbi Chagas disease
    Anis Rassi
    Division of Cardiology, Anis Rassi Hospital, Goiania, GO, Brazil
    Lancet 375:1388-402. 2010
    b>Chagas disease is a chronic, systemic, parasitic infection caused by the protozoan Trypanosoma cruzi, and was discovered in 1909...
  2. ncbi The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications
    Bianca Zingales
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Avenida Professor Lineu Prestes 748, 05508 000 Sao Paulo, SP, Brazil
    Infect Genet Evol 12:240-53. 2012
    ..The human infection, named Chagas disease, is a major public health problem for Latin America. T...
  3. ncbi Chagas disease: a Latin American health problem becoming a world health problem
    Gabriel A Schmunis
    Health Surveillance, Disease Prevention and Control, Pan American Health Organization, Regional Office of the World Health Organization, 525 23th Street N W, Washington, DC 20037, USA
    Acta Trop 115:14-21. 2010
    ..and/or economic stagnation stimulated the flow of migration from the 17 Latin American countries endemic for Chagas disease to developed countries...
  4. pmc Global economic burden of Chagas disease: a computational simulation model
    Bruce Y Lee
    Public Health Computational and Operations Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Lancet Infect Dis 13:342-8. 2013
    As Chagas disease continues to expand beyond tropical and subtropical zones, a growing need exists to better understand its resulting economic burden to help guide stakeholders such as policy makers, funders, and product developers...
  5. ncbi American trypanosomiasis (Chagas disease)
    Anis Rassi
    Division of Cardiology, Anis Rassi Hospital, Avenida José Alves 453, Setor Oeste, Goiania, GO 74110 020, Brazil
    Infect Dis Clin North Am 26:275-91. 2012
    b>Chagas disease, also known as American trypanosomiasis, is a chronic infection caused by Trypanosoma cruzi, a protozoan parasite. It is transmitted to human beings mainly through the feces of infected triatomine bugs...
  6. pmc The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University and Sabin Vaccine Institute, Washington, DC, USA
    PLoS Negl Trop Dis 2:e300. 2008
    ..healthy life years lost from disability, hookworm infection, other soil-transmitted helminth infections, and Chagas disease are the most important NTDs in LAC, followed by dengue, schistosomiasis, leishmaniasis, trachoma, leprosy, and ..
  7. pmc Mechanisms of Trypanosoma cruzi persistence in Chagas disease
    Fnu Nagajyothi
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 14:634-43. 2012
    Trypanosoma cruzi infection leads to development of chronic Chagas disease. In this article, we provide an update on the current knowledge of the mechanisms employed by the parasite to gain entry into the host cells and establish ..
  8. ncbi Chagas disease in Spain, the United States and other non-endemic countries
    Joaquim Gascon
    Centre de Salut Internacional, CRESIB, Hospital Clinic, IDIBAPS, C Villarroel, 170, 08036, Barcelona, Spain
    Acta Trop 115:22-7. 2010
    Due to recent trends in migration, there are millions of people from Chagas disease-endemic countries now living in North America, Europe, Australia and Japan, including thousands of people with Trypanosoma cruzi infection...
  9. ncbi Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy
    Alvaro Moncayo
    Academia Nacional de Medicina, Bogota, Colombia
    Mem Inst Oswaldo Cruz 104:17-30. 2009
    b>Chagas disease, named after Carlos Chagas, who first described it in 1909, exists only on the American Continent...
  10. ncbi Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches
    Julio A Urbina
    Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Acta Trop 115:55-68. 2010
    ..of the development of specific chemotherapeutic approaches for the management of American Trypanosomiasis or Chagas disease is presented, including controversies on the pathogenesis of the disease, the initial efforts that led to the ..
  11. ncbi Contemporary cryptic sexuality in Trypanosoma cruzi
    Juan David Ramírez
    Centro de Investigaciones en Microbiologia y Parasitologia Tropical, Universidad de Los Andes, Bogota, Colombia
    Mol Ecol 21:4216-26. 2012
    ..Trypanosoma cruzi, which causes Chagas disease, is known to undergo non-Mendelian genetic exchange in the laboratory...
  12. ncbi An estimate of the burden of Chagas disease in the United States
    Caryn Bern
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 49:e52-4. 2009
    b>Chagas disease causes the highest burden of any parasitic disease in the Western hemisphere...
  13. ncbi Chagas disease. What is known and what should be improved: a systemic review
    José Rodrigues Coura
    Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brasil
    Rev Soc Bras Med Trop 45:286-96. 2012
    This study consists of a broad review on what is known and what should be improved regarding knowledge of Chagas disease, not only through analysis on the main studies published on the topics discussed, but to a large extent based on ..
  14. ncbi The impact of Chagas disease control in Latin America: a review
    J C P Dias
    Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, 30190 002, Brasil
    Mem Inst Oswaldo Cruz 97:603-12. 2002
    Discovered in 1909, Chagas disease was progressively shown to be widespread throughout Latin America, affecting millions of rural people with a high impact on morbidity and mortality...
  15. pmc Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease
    Fabiana S Machado
    Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Semin Immunopathol 34:753-70. 2012
    b>Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical disease and a cause of significant morbidity and mortality...
  16. ncbi Oral transmission of Chagas disease
    Maria Aparecida Shikanai-Yasuda
    Department of Infectious and Parasitic Diseases, das Clínicas, Faculdade de Medicina, University of Sao Paulo, Brazil
    Clin Infect Dis 54:845-52. 2012
    b>Chagas disease is now an active disease in the urban centers of countries of nonendemicity and endemicity because of congenital and blood and/or organ transplantation transmissions and the reactivation of the chronic disease in smaller ..
  17. ncbi A critical review on Chagas disease chemotherapy
    José Rodriques Coura
    Departamento de Medicina Tropical, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, 21045 900 Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 97:3-24. 2002
    In this "Critical Review" we made a historical introduction of drugs assayed against Chagas disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental use of nitrofurazone...
  18. pmc International study to evaluate PCR methods for detection of Trypanosoma cruzi DNA in blood samples from Chagas disease patients
    Alejandro G Schijman
    Laboratorio de Biología Molecular de Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular INGEBI CONICET, Buenos Aires, Argentina
    PLoS Negl Trop Dis 5:e931. 2011
    A century after its discovery, Chagas disease still represents a major neglected tropical threat. Accurate diagnostics tools as well as surrogate markers of parasitological response to treatment are research priorities in the field...
  19. ncbi Chagas disease: 100 years after its discovery. A systemic review
    José Rodrigues Coura
    Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brazil
    Acta Trop 115:5-13. 2010
    Although Chagas disease was only discovered in 1909, it began millions of years ago as an enzootic disease among wild animals. Its transmission to man began accidentally as an anthropozoonosis when mankind invaded wild ecotopes...
  20. pmc Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi
    C A Machado
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 98:7396-401. 2001
    ..We estimate that the major extant lineages of T. cruzi have diverged during the Miocene or early Pliocene (3-16 million years ago)...
  21. ncbi The United States Trypanosoma cruzi Infection Study: evidence for vector-borne transmission of the parasite that causes Chagas disease among United States blood donors
    Paul T Cantey
    Epidemic Intelligence Service, Office of Surveillance, Epidemiology, and Laboratory Services, and Division of Parasitic Diseases and Malaria, Center for Global Health, CDC, Atlanta, Georgia 30333, USA
    Transfusion 52:1922-30. 2012
    ..cruzi Infection Study was conducted to evaluate the burden of and describe putative risk factors for vector-borne infection in the United States...
  22. ncbi Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)
    Jose A Castro
    Centro de Investigaciones Toxicológicas CEITOX CITEFA CONICET, J B de La Salle 4397, Villa Martelli, Pcia de Buenos Aires 1603, Argentina
    Hum Exp Toxicol 25:471-9. 2006
    ..Those processes are fundamentally mediated by cytochrome P450 reductase and cytochrome P450. Other enzymes such as xanthine oxidoreductase or aldehyde oxidase may also be involved...
  23. ncbi Clinical and epidemiological aspects of Chagas disease
    A Prata
    Tropical Medicine Departament, Faculdade de Medicina do Triangulo Mineiro, Uberaba, MG, Brazil
    Lancet Infect Dis 1:92-100. 2001
    b>Chagas disease is caused by the protozoan parasite Trypanosoma cruzi...
  24. ncbi Trypanosoma cruzi I diversity: towards the need of genetic subdivision?
    Felipe Guhl
    Centro de Investigaciones en Microbiologia y Parasitologia Tropical, CIMPAT, Universidad de Los Andes, Cra 1 No 18A 10, Bogota, Colombia
    Acta Trop 119:1-4. 2011
    Trypanosoma cruzi the aethiological agent of Chagas disease, a complex zoonoses that affects the American continent is a genetically variable parasite subdivided into six Discrete Typing Units (DTUs). T...
  25. ncbi Adverse events after the use of benznidazole in infants and children with Chagas disease
    Jaime Altcheh
    Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños R Gutiérrez, Gallo 1330, Buenos Aires 1425, Argentina
    Pediatrics 127:e212-8. 2011
    b>Chagas disease is caused by infection with Trypanosoma cruzi. In adults, treatment with benznidazole is associated with a high incidence of adverse drug reactions (ADRs)...
  26. pmc Public street lights increase house infestation by the Chagas disease vector Triatoma dimidiata
    Freddy Santiago Pacheco-Tucuch
    Laboratorio de Parasitologia, Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico
    PLoS ONE 7:e36207. 2012
    Triatoma dimidiata is one of the primary vectors of Chagas disease. We previously documented the spatio-temporal infestation of houses by this species in the Yucatan peninsula, Mexico, and found that non-domiciliated triatomines were ..
  27. pmc Certifying the interruption of Chagas disease transmission by native vectors: cui bono?
    Fernando Abad-Franch
    Instituto Leônidas e Maria Deane Fiocruz, Manaus, AM, Brasil
    Mem Inst Oswaldo Cruz 108:251-4. 2013
    Certifying the absence of Chagas disease transmission by native vectors lacks scientific grounds and weakens long-term control-surveillance systems to the detriment of people living under risk conditions...
  28. ncbi Risks of endemicity, morbidity and perspectives regarding the control of Chagas disease in the Amazon Region
    José Rodrigues Coura
    Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 107:145-54. 2012
    b>Chagas disease, in the Amazon Region as elsewhere, can be considered an enzootic disease of wild animals or an anthropozoonosis, an accidental disease of humans that is acquired when humans penetrate a wild ecosystem or when wild ..
  29. ncbi Comparative phylogeography of Trypanosoma cruzi TCIIc: new hosts, association with terrestrial ecotopes, and spatial clustering
    Arlei Marcili
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brazil
    Infect Genet Evol 9:1265-74. 2009
    ..Analysis of ITS1 rDNA sequences disclosed clusters of TCIIc isolates in accordance with their geographic origin, independent of their host species...
  30. ncbi Severity of chronic Chagas disease is associated with cytokine/antioxidant imbalance in chronically infected individuals
    Ricardo Pérez-Fuentes
    Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, 13 Sur 2901 Col Volcanes, C P 72000, Pue, Puebla, Mexico
    Int J Parasitol 33:293-9. 2003
    Understanding the pathogenic mechanisms in chronic Chagas disease, a major cause of morbidity and mortality in Latin America, is essential for the design of rational therapeutic strategies...
  31. ncbi Insecticide resistance of Triatoma infestans (Hemiptera, Reduviidae) vector of Chagas disease in Bolivia
    Frederic Lardeux
    Institut de Recherche pour le Developpement, Montpellier, France
    Trop Med Int Health 15:1037-48. 2010
    ..To define the insecticide resistance status of Triatoma infestans to deltamethrin (pyrethroid), malathion (organophosphate) and bendiocarb (carbamate) in Bolivia...
  32. ncbi Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity
    F F de Araújo
    Laboratorio de Imunologia Celular e Molecular, Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, Brazil
    Immunobiology 217:768-77. 2012
    Immunoregulatory mechanisms are important to control the intense immune activity induced in Chagas disease. We evaluated the phenotypic profile and the mechanisms by which Treg cells function in patients with the indeterminate (IND) and ..
  33. ncbi Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally infected and non-infected newborns in Bolivia
    Faustino Torrico
    Centro Universitario de Medicina Tropical, Facultad de Medicina, Universidad Mayor de San Simon, Casilla, Cochabamba, Bolivia
    Am J Trop Med Hyg 70:201-9. 2004
    ..Neonatal mortality related to congenital Chagas disease also decreased from 13% to 2% in the interval between both studies...
  34. pmc Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease
    María Jesús Pinazo
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 57:390-5. 2013
    For treating Chagas disease (CD), a current worldwide health problem, only benznidazole and nifurtimox have been approved to be used...
  35. ncbi Nested clade and phylogeographic analyses of the Chagas disease vector Triatoma brasiliensis in Northeast Brazil
    Fernando A Monteiro
    Departamento de Medicina Tropical, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, Rio de Janeiro, RJ 21045 900, Brazil
    Mol Phylogenet Evol 32:46-56. 2004
    Triatoma brasiliensis (Hemiptera: Reduviidae: Triatominae) is the most important Chagas disease vector in the semiarid areas of Northeast Brazil...
  36. ncbi Vaccine development against Trypanosoma cruzi and Chagas disease
    Juan C Vazquez-Chagoyan
    Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Estado de México, Toluca, Mexico
    Adv Parasitol 75:121-46. 2011
    The pathology of Chagas disease presents a complicated and diverse picture in humans...
  37. pmc Community participation in Chagas disease vector surveillance: systematic review
    Fernando Abad-Franch
    Instituto Leônidas e Maria Deane Fiocruz Amazônia, Manaus, Brazil
    PLoS Negl Trop Dis 5:e1207. 2011
    Vector control has substantially reduced Chagas disease (ChD) incidence...
  38. ncbi Interactions between intestinal compounds of triatomines and Trypanosoma cruzi
    Eloi S Garcia
    Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Manguinhos, CEP, Rio de Janeiro, Brazil
    Trends Parasitol 26:499-505. 2010
    Triatomine bugs are vectors of Trypanosoma cruzi, the etiologic agent of Chagas disease, a devastating disease that disables and leads to the death of many people in Latin America...
  39. pmc Evaluation of spatially targeted strategies to control non-domiciliated Triatoma dimidiata vector of Chagas disease
    Corentin Barbu
    UMR 5244 CNRS UPVD EPHE, Biologie et Ecologie Tropicale et Méditerranéenne, Universite de Perpignan Via Domitia, Perpignan, France
    PLoS Negl Trop Dis 5:e1045. 2011
    b>Chagas disease is a major neglected tropical disease with deep socio-economical effects throughout Central and South America...
  40. pmc Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion
    Maria Cecilia Fernandes
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Exp Med 208:909-21. 2011
    ..Thus, T. cruzi subverts the ASM-dependent ceramide-enriched endosomes that function in plasma membrane repair to infect host cells...
  41. pmc Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infection
    Martin S Llewellyn
    London School of Hygiene and Tropical Medicine, London, UK
    PLoS Pathog 5:e1000410. 2009
    ..The epidemiological significance of these findings is discussed...
  42. pmc Sex, subdivision, and domestic dispersal of Trypanosoma cruzi lineage I in southern Ecuador
    Sofía Ocaña-Mayorga
    Centro de Investigación en Enfermedades Infecciosas, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador
    PLoS Negl Trop Dis 4:e915. 2010
    ..We evaluated the molecular diversity of Trypanosoma cruzi, the etiological agent of Chagas disease, in southern Ecuador (Loja Province)...
  43. ncbi Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease
    L S Filardi
    Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, Brazil
    Trans R Soc Trop Med Hyg 81:755-9. 1987
    The susceptibility and natural resistance to two nitroheterocyclic derivatives used clinically in Chagas disease (nifurtimox and benznidazole) were investigated in 47 Trypanosoma cruzi strains isolated from human patients, domestic ..
  44. ncbi Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids
    Matthew Yeo
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Int J Parasitol 35:225-33. 2005
    Trypanosoma cruzi, the causative agent of Chagas disease, has at least two principal intraspecific subdivisions, T. cruzi I (TCI) and T. cruzi II (TCII), the latter containing up to five subgroups (a-e)...
  45. ncbi Evaluation and treatment of chagas disease in the United States: a systematic review
    Caryn Bern
    Parasitic Diseases Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    JAMA 298:2171-81. 2007
    ..Because of population migration from endemic areas and newly instituted blood bank screening, US clinicians are likely to see an increasing number of patients with suspected or confirmed chronic Trypanosoma cruzi infection (Chagas disease).
  46. ncbi Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusional Chagas disease. Historical aspects, present situation, and perspectives
    João Carlos Pinto Dias
    Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima 1715, 30140 002 Belo Horizonte, MG, Brasil
    Mem Inst Oswaldo Cruz 102:11-8. 2007
    ..Brazil, Chile, Paraguay, and Uruguay, the Southern Cone Initiative (SCI) has been extremely important for Chagas disease control in this region...
  47. ncbi The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
    Najib M El-Sayed
    Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
    Science 309:409-15. 2005
    ....
  48. ncbi Development and validation of a risk score for predicting death in Chagas' heart disease
    Anis Rassi
    Division of Cardiology, Anis Rassi Hospital, Goiania, Brazil
    N Engl J Med 355:799-808. 2006
    ..Chagas' disease is an important health problem in Latin America, and cardiac involvement is associated with substantial morbidity and mortality. We developed a model to predict the risk of death in patients with Chagas' heart disease...
  49. ncbi The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future
    M A Miles
    Pathogen Molecular Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Parasitology 136:1509-28. 2009
    Trypanosoma cruzi is the protozoan agent of Chagas disease, and the most important parasitic disease in Latin America...
  50. ncbi Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease
    Susana A Laucella
    Instituto Nacional de Parasitologia Dr Mario Fatala Chaben, Buenos Aires, Argentina
    J Infect Dis 189:909-18. 2004
    ..In the majority of patients with Chagas disease, staining with class I major histocompatibility complex tetramers and analysis of interferon (IFN)- gamma ..
  51. pmc IFN-γ plays a unique role in protection against low virulent Trypanosoma cruzi strain
    Adele A Rodrigues
    Instituto de Ciencias Biomedicas, Universidade Federal de Uberlandia, Uberlandia, Minas Gerais, Brazil
    PLoS Negl Trop Dis 6:e1598. 2012
    ..cruzi I) are highly infective in vitro and show no parasitemia in vivo. Here we aimed to understand why amastigotes from G strain are highly infective in vitro and do not contribute for a patent in vivo infection...
  52. ncbi Predicting triatoma dimidiata abundance and infection rate: a risk map for natural transmission of chagas disease in the yucatan peninsula of Mexico
    Eric Dumonteil
    Laboratorio de Parasitologia, Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Mexico
    Am J Trop Med Hyg 70:514-9. 2004
    b>Chagas disease, a major public health problem in Latin America, is caused by the protozoan parasite Trypanosoma cruzi and transmitted by hematophageous insects from the Triatominae subfamily...
  53. pmc Chagas disease: assessing the existence of a threshold for bug infestation rate
    Hirotsugu Aiga
    Human Development Department, Japan International Cooperation Agency JICA, Tokyo, Japan
    Am J Trop Med Hyg 86:972-9. 2012
    ..rate of Triatoma dimidiata, below which transmission becomes unlikely, a census was conducted in 59 Chagas disease endemic communities of El Salvador and Honduras...
  54. ncbi Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections
    Frederick S Buckner
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Adv Exp Med Biol 625:61-80. 2008
    b>Chagas disease is caused by infection with the protozoan pathogen, Trypanosoma cruzi...
  55. ncbi Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas disease
    L Lopez
    Instituto de Biologia, Universidad de Antioquia, Calle 67 No 53 108, Medellin, Colombia
    Insect Biochem Mol Biol 33:439-47. 2003
    ..associated with innate immunity in insects was isolated from the hemolymph of Rhodnius prolixus, a vector of Chagas disease. This peptide, designated R. prolixus defensin A, was purified and sequenced...
  56. ncbi Parasitic diseases of the heart
    Louis V Kirchhoff
    Departments of Internal Medicine Infectious Diseases and Epidemiology, University of Iowa, Iowa City, USA
    Front Biosci 9:706-23. 2004
    ..The larval forms of the tapeworms Echinococcus and Taenia solium may cause space-occupying lesions of the heart. Severe infection with the nematode Trichinella spiralis may cause myocarditis...
  57. ncbi Identification of a large hybrid zone between sympatric sibling species of Triatoma dimidiata in the Yucatan peninsula, Mexico, and its epidemiological importance
    Melba Herrera-Aguilar
    Laboratorio de Parasitologia, Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico
    Infect Genet Evol 9:1345-51. 2009
    Triatoma dimidiata is one of the major Chagas disease vectors, with an extensive diversity in its morphology, habitat, and level of domiciliation...
  58. ncbi [Updated geographical distribution and ecoepidemiology of the triatomine fauna (Reduviidae: Triatominae) in Colombia]
    Felipe Guhl
    Centro de Investigaciones en Microbiologia y Parasitologia Tropical, Facultad de Ciencias, Universidad de Los Andes, Bogota, Colombia
    Biomedica 27:143-62. 2007
    ..Entomological surveillance providess a necessary tool to reinforce the control strategies for Chagas disease. This also allows the evaluation of transmission risk that the sylvatic triatomines represent in Colombia.
  59. ncbi Dispersal of Triatoma infestans and other Triatominae species in the arid Chaco of Argentina: flying, walking or passive carriage? The importance of walking females
    Luciana Beatriz Abrahan
    Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja, Anillaco, La Rioja, Argentina
    Mem Inst Oswaldo Cruz 106:232-9. 2011
    ..However, manual inspection of 122 chickens suggests that it is unlikely that these animals passively transport T. infestans. Finally, the dispersal activity of T. infestans was compared with other triatomines using a dispersion index...
  60. ncbi Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/"indeterminate" and Chagas disease cardiomyopathy patients
    Renata Cristina Ferreira
    Divisão de Cardiopatias Gerais, Instituto do Coracao, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, 05403 000, Brasil
    Mem Inst Oswaldo Cruz 98:407-11. 2003
    We compared plasma tumor necrosis factor-alpha (TNF-alpha) levels among asymptomatic/"indeterminate" Chagas disease patients (ASY) and patients across the clinical spectrum of chronic Chagas disease cardiomyopathy (CCC)...
  61. ncbi Tolerance and safety of nifurtimox in patients with chronic chagas disease
    Yves Jackson
    Divisionof Primary Care Medicine, Department of Community Medicine and Primary Care, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
    Clin Infect Dis 51:e69-75. 2010
    Nifurtimox has been used to treat Chagas disease for 40 years, but tolerance and safety data in adults are scarce...
  62. ncbi Congenital Chagas disease: estimating the potential risk in the United States
    Zaida E Yadon
    Health Surveillance, Disease Prevention and Control, Pan American Health Organization, Washington, DC 20037 2895, USA
    Am J Trop Med Hyg 81:927-33. 2009
    ..cruzi-infected population from Latin American countries to the United States and Europe; originating cases of Chagas disease were transmitted through blood, organ donation, and vertical transmission...
  63. pmc Unexpected failures to control Chagas Disease vectors with pyrethroid spraying in northern Argentina
    Juan M Gurevitz
    Department of Ecology, Genetics and Evolution, Universidad de Buenos Aires, Ciudad Universitaria, Argentina
    J Med Entomol 49:1379-86. 2012
    ..Our results underline the need for close monitoring of the impact of insecticide spraying to provide early warning of possible problems because of enhanced resistance or tolerance and determine appropriate responses...
  64. ncbi Oxidative damage during chagasic cardiomyopathy development: role of mitochondrial oxidant release and inefficient antioxidant defense
    Jian Jun Wen
    Department of Microbiology and Immunology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA
    Free Radic Biol Med 37:1821-33. 2004
    ....
  65. ncbi A role for extracellular amastigotes in the immunopathology of Chagas disease
    J Scharfstein
    Laboratório de Imunologia Molecular, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
    Mem Inst Oswaldo Cruz 94:51-63. 1999
    ..of Trypanosoma cruzi infection, the mechanisms responsible for the variable clinico-pathological expression of Chagas disease remain unknown...
  66. pmc Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids
    Michael D Lewis
    Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e1363. 2011
    ..Trypanosoma cruzi, a parasite transmitted by numerous species of triatomine bug in the Americas, causes Chagas disease in humans. T. cruzi generally reproduces asexually and appears to have a clonal population structure...
  67. pmc Analyses of 32 loci clarify phylogenetic relationships among Trypanosoma cruzi lineages and support a single hybridization prior to human contact
    Carlos A Flores-López
    Department of Biology, University of Maryland, College Park, MD, USA
    PLoS Negl Trop Dis 5:e1272. 2011
    The genetic diversity of Trypanosoma cruzi, the etiological agent of Chagas disease, has been traditionally divided in two major groups, T...
  68. ncbi Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients
    Jian Jun Wen
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Free Radic Biol Med 41:270-6. 2006
    ..oxidative damage and mitochondrial functional decline and might be of pathological significance in Chagas disease. In the present study, we investigated whether enhanced oxidative stress and mitochondrial functional decline ..
  69. ncbi Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992-2007
    Ezequiel Cordova
    Francisco J Muñiz Infectious Diseases Hospital, Uspallata 2262, Buenos Aires, Argentina
    Int J Infect Dis 12:587-92. 2008
    The objective of this study was to evaluate clinical and microbiological characteristics of Chagas disease (ChD) with central nervous system (CNS) involvement in AIDS patients.
  70. ncbi Fighting the oxidative assault: the Trypanosoma cruzi journey to infection
    Lucia Piacenza
    Departamento de Bioquimica, Facultad de Medicina, Universidad de la Republica, Montevideo Uruguay, Uruguay
    Curr Opin Microbiol 12:415-21. 2009
    ..parasites more prepared to deal with the host-oxidative assault are more efficient for the establishment of Chagas disease. For instance, parasites overexpressing peroxiredoxins are more resistant to macrophage-derived peroxynitrite, ..
  71. pmc Genetic transformation of a Corynebacterial symbiont from the Chagas disease vector Triatoma infestans
    Ravi V Durvasula
    Department of Internal Medicine, University of New Mexico, 915 Camino Del Salud NE, CRF 305, Albuquerque, NM 87131, USA
    Exp Parasitol 119:94-8. 2008
    ..Previously, we developed paratransgenic lines of Rhodnius prolixus, a vector of Chagas disease in Central America...
  72. ncbi Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial
    Rodolfo Viotti
    Hospital Interzonal General de Agudos Eva Perón and Instituto Nacional de Parasitología Dr Mario Fatala Chaben, Buenos Aires, Argentina
    Ann Intern Med 144:724-34. 2006
    Benznidazole is effective for treating acute-stage Chagas disease, but its effectiveness for treating indeterminate and chronic stages remains uncertain.
  73. ncbi Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection
    Andre Bafica
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 177:3515-9. 2006
    ..Our results reveal that TLR2 and TLR9 cooperate in the control of parasite replication and that TLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-gamma synthesis during infection with T. cruzi...
  74. pmc Sustainability of vector control strategies in the Gran Chaco Region: current challenges and possible approaches
    Ricardo E Gürtler
    Laboratory of Eco Epidemiology, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Mem Inst Oswaldo Cruz 104:52-9. 2009
    ..b>Chagas disease control programs traditionally have been composed of two divorced entities: a vector control program in charge ..
  75. ncbi Ergosterol biosynthesis and drug development for Chagas disease
    Julio A Urbina
    Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Mem Inst Oswaldo Cruz 104:311-8. 2009
    ..drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis ..
  76. pmc Pathogenesis of chagas' disease: parasite persistence and autoimmunity
    Antonio R L Teixeira
    Chagas Disease Multidisciplinary Research Laboratory, University of Brasilia, Federal District, Brazil
    Clin Microbiol Rev 24:592-630. 2011
    ..These results suggest that the inflammatory cardiomyopathy of Chagas' disease is a genetically driven autoimmune disease...
  77. pmc Genetics and evolution of triatomines: from phylogeny to vector control
    S Gourbiere
    UMR 5244 CNRS UPVD Ecologie et Evolution des Interactions, Universite de Perpignan Via Domitia, Perpignan, France
    Heredity (Edinb) 108:190-202. 2012
    ..This parasite causes Chagas disease, one of the major parasitic diseases in the Americas...
  78. pmc Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors
    J Scharfstein
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CEP 21990 400 Rio de Janeiro, Brazil
    J Exp Med 192:1289-300. 2000
    ..Analysis of trypomastigote transfectants expressing various cysteine proteinase isoforms showed that invasion competence is linked to the kinin releasing activity of cruzipain, herein proposed as a factor of virulence in Chagas' disease...
  79. ncbi Predominance of lineage I among Trypanosoma cruzi isolates from Venezuelan patients with different clinical profiles of acute Chagas' disease
    Néstor Añez
    Departamento de Biologia, Universidad de Los Andes, Facultad de Ciencias, Merida, Venezuela
    Trop Med Int Health 9:1319-26. 2004
    ..cruzi I infection to humans. To our knowledge, this is the first study describing predominance of T. cruzi lineage I in a large number of acute chagasic patients with distinct and well-characterized clinical profiles...
  80. ncbi Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas, Venezuela
    Belkisyolé Alarcón de Noya
    Departments of Immunology, Instituto de Medicina Tropical, Universidad Central de Venezuela Código Postal 1041, Los Chaguaramos, Caracas, Venezuela
    J Infect Dis 201:1308-15. 2010
    Trypanosoma cruzi oral transmission is possible through food contamination by vector's feces. Little is known about the epidemiology and clinical features of microepidemics of orally acquired acute Chagas disease (CD).
  81. ncbi Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission
    Arlei Marcili
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Int J Parasitol 39:615-23. 2009
    ..13 TCI and nine TCIIa), and humans with Chagas disease associated with oral transmission (14 TCI and five TCIIa) in Brazilian Amazonia...
  82. ncbi The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease
    Caroline Junqueira
    Laboratorio de Immunopatologia, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, MG, Brazil
    Expert Rev Mol Med 12:e29. 2010
    Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is characterised by a variable clinical course - from symptomless cases to severe chronic disease with cardiac and/or gastrointestinal involvement...
  83. ncbi Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages
    C G Freire-de-Lima
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, RJ, Brazil
    Nature 403:199-203. 2000
    ....
  84. pmc Periurban Trypanosoma cruzi-infected Triatoma infestans, Arequipa, Peru
    Michael Zachary Levy
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Emerg Infect Dis 12:1345-52. 2006
    In Arequipa, Peru, vectorborne transmission of Chagas disease by Triatoma infestans has become an urban problem...
  85. ncbi Chagas disease: what is known and what is needed--a background article
    José Rodrigues Coura
    Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, 21045 900, Brasil
    Mem Inst Oswaldo Cruz 102:113-22. 2007
    b>Chagas disease began millions of years ago as an enzootic disease of wild animals and started to be transmitted to man accidentally in the form of an anthropozoonosis when man invaded wild ecotopes...
  86. pmc Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection
    V Michailowsky
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Am J Pathol 159:1723-33. 2001
    ..cruzi. Thus, our results suggest that the level of IFN-gamma deficiency is a major determinant of the site of reactivation of T. cruzi infection in immunocompromised host...
  87. ncbi Development of a real-time PCR assay for Trypanosoma cruzi detection in blood samples
    Maria Piron
    Transfusion Safety Laboratory, Banc de Sang i Teixits, Barcelona, Spain
    Acta Trop 103:195-200. 2007
    ..Concordance of results with the N-PCR was 90%. In conclusion, real-time PCR provides an optimal alternative to N-PCR, with similar sensitivity and higher throughput, and could help determine ongoing parasitaemia in chagasic patients...
  88. pmc CD8+ T cells in Trypanosoma cruzi infection
    Angel M Padilla
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Curr Opin Immunol 21:385-90. 2009
    ..players in the control of a number of protozoan pathogens, including Trypanosoma cruzi, the agent of human Chagas disease. The recent identification of the dominant targets of T...
  89. pmc Accurate real-time PCR strategy for monitoring bloodstream parasitic loads in chagas disease patients
    Tomas Duffy
    Laboratorio de Biologia Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular INGEBI CONICET, Buenos Aires, Argentina
    PLoS Negl Trop Dis 3:e419. 2009
    This report describes a real-time PCR (Q-PCR) strategy to quantify Trypanosoma cruzi (T. cruzi) DNA in peripheral blood samples from Chagas disease patients targeted to conserved motifs within the repetitive satellite sequence.
  90. pmc Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination
    Bruna C G de Alencar
    Centro Interdisciplinar de Terapia Gênica CINTERGEN, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Mirassol 207, Sao Paulo, SP 04044 010, Brazil
    Infect Immun 77:4383-95. 2009
    ..Our study thus demonstrated a role for perforin and IFN-gamma in a number of T-cell-mediated effector functions and in the antiparasitic immunity generated by a heterologous plasmid DNA prime-adenovirus boost vaccination strategy...
  91. pmc Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection
    J C Engel
    Department of Pathology, University of California San Francisco, California 94143, USA
    J Exp Med 188:725-34. 1998
    ..No abnormalities were noted in the Golgi complex of host cells. This study provides proof of concept that cysteine protease inhibitors can be given at therapeutic doses to animals to selectively arrest a parasitic infection...
  92. pmc Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection
    J C Aliberti
    Departments of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Av Bandeirantes, 3900, 14 049 900, Ribeirao Preto, Sao Paulo, Brazil
    Am J Pathol 158:1433-40. 2001
    ..cruzi infection and mediate resistance to infection...
  93. ncbi Chemokines, inflammation and Trypanosoma cruzi infection
    Mauro M Teixeira
    Departmento Bioquímica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Pampulha, 31270 901, Belo Horizonte, MG, Brazil
    Trends Parasitol 18:262-5. 2002
    ..is essential for host resistance to infection but is also responsible for the diverse pathology observed in Chagas disease. Here, we examine the stimuli and mechanisms underlying chemokine production following infection in vitro and ..
  94. ncbi Genetic susceptibility to chronic Chagas disease: an overview of single nucleotide polymorphisms of cytokine genes
    Romero H T Vasconcelos
    Department of Immunology, Centro de Pesquisas Aggeu Magalhaes, Recife, Brazil
    Cytokine 59:203-8. 2012
    b>Chagas disease is a parasitic infection that is a significant public health problem in Latin America...
  95. pmc Hidden sylvatic foci of the main vector of Chagas disease Triatoma infestans: threats to the vector elimination campaign?
    Leonardo A Ceballos
    Laboratory of Eco Epidemiology, Department of Ecology, Genetics and Evolution, Universidad de Buenos Aires, Buenos Aires, Argentina
    PLoS Negl Trop Dis 5:e1365. 2011
    ....
  96. ncbi Pre-Columbian Chagas disease in Brazil: Trypanosoma cruzi I in the archaeological remains of a human in Peruaçu Valley, Minas Gerais, Brazil
    Alexandre Fernandes
    Laboratório de Genética Molecular de Microorganismos, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, Brasil
    Mem Inst Oswaldo Cruz 103:514-6. 2008
    ..cruzi I genotype. This finding suggests that T. cruzi I infected humans during the pre-Columbian times and that, in addition to T. cruzi infection, Chagas disease in Brazil most likely preceded European colonization.
  97. ncbi Update in treatment of Chagas disease
    Guillaume Le Loup
    Service des Maladies Infectieuse et Tropicales, Hôpitaux Universitaires Paris Est Tenon, AP HP, Universite Pierre et Marie Curie, Paris, France
    Curr Opin Infect Dis 24:428-34. 2011
    This review discusses the recent data about the pathogenesis of Chagas disease, tolerance of drugs, and follow-up of patients impacting the treatment of Chagas disease in immunocompetent and immunocompromised patients.
  98. ncbi Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis
    José A Pérez-Molina
    Tropical Medicine Unit, Infectious Diseases Department, Hospital Ramon y Cajal, Madrid, Spain
    J Antimicrob Chemother 64:1139-47. 2009
    ..Our objectives were to evaluate published evidence on the treatment of chronic Chagas' disease with benznidazole and on the potential benefits of this drug in the chronic phase of the disease...
  99. ncbi Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease
    Margoth Moreno
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 105:918-24. 2010
    Therapeutic failure of benznidazole (BZ) is widely documented in Chagas disease and has been primarily associated with variations in the drug susceptibility of Trypanosoma cruzi strains...
  100. pmc ELISA versus PCR for diagnosis of chronic Chagas disease: systematic review and meta-analysis
    Pedro E A A Brasil
    Instituto de Pesquisa Clínica Evandro Chagas Fundação Oswaldo Cruz, Rio de Janeiro RJ, Brazil
    BMC Infect Dis 10:337. 2010
    Most current guidelines recommend two serological tests to diagnose chronic Chagas disease. When serological tests are persistently inconclusive, some guidelines recommend molecular tests...
  101. pmc Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice
    Kara L Cummings
    Center for Tropical and Emerging Global Diseases, 623 Biological Sciences Building, University of Georgia, Athens, GA 30602, USA
    Infect Immun 72:4081-9. 2004
    ..These results clearly show that iNOS is not required for control of T. cruzi infection in mice...

Research Grants69

  1. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..If effective, this technology could potentially be applied to other infectious agents such as malaria and tuberculosis in the future. ..
  2. Pathogenesis of Oxidative Stress in Chagas Disease
    Nisha Jain Garg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chagas disease is caused by the protozoan Trypanosoma cruzi, and represents the third greatest tropical disease burden globally...
  3. Role of Lipoproteins in Chagasic heart disease
    JYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chagas disease, caused by an intracellular parasite Trypanosoma cruzi, is a major public health problem with significant social and economic implications in most Latin American countries and among ..
  4. Mitochondrial Biomarkers of Cardiomyopathy and Cure in Chagas Disease
    Nisha Jain Garg; Fiscal Year: 2013
    ..gt;300,000 patients in the US and >10 million patients in endemic countries, and total annual cost of Chagas disease management is estimated at >8 billion US dollars...
  5. Rational Development of Anti-Trypanosoma Cruzi Drugs
    Michael H Gelb; Fiscal Year: 2013
    ..of the proposed research is to develop inhibitors of the sterol 14a-demethylase (14DM) enzyme for treating Chagas disease. Trypanosoma cruzi, the etiologic agent of Chagas disease, is widespread in Latin America and causes ..
  6. K777 for treatment of Chagas Disease: IND-enabling Studies and IND Submission
    Robert Don; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chagas disease remains a major health problem in Latin America due to lack of an effective preventative vaccine and inadequate treatments post-infection...
  7. Role of mucin-type O-glycosylation in Trypanosoma cruzi biology
    Christopher M West; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Trypanosoma cruzi is a single-cell protozoan parasite that causes Chagas disease, characterized by cardiac or gastrointestinal complications in chronically infected patients...
  8. Olfactory and behavioral responses of kissing bugs (Reduviidae: Triatominae), vec
    John G Hildebrand; Fiscal Year: 2010
    ..are blood-sucking insects, vectors of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas Disease. This Disease is endemic in Mexico, Central and South America and affects about 11-13 million people...
  9. FUNCTION OF THE KINETOPLAST IN THE HEMOFLAGELLATES
    Larry Simpson; Fiscal Year: 2013
    ..significance is that these parasites are the causal agents of a number of important human diseases including Chagas Disease, Leishmaniasis and African Sleeping Sickness, and that the editing pathway is essential in all stages of the ..
  10. Geographically robust rapid assay for T. cruzi infection
    SYAMAL X RAYCHAUDHURI; Fiscal Year: 2010
    ..is transmitted via blood transfusions, is prevalent in Latin America, and is the causative agent for fatal chagas disease. Positive blood donors have been identified, and transmission via the insect vector has been reported in the ..
  11. Synthesis of immunogenic glycolipopeptides for the development of vaccines for Ch
    Katja Michael; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Trypanosoma cruzi is a protozoan parasite that causes Chagas disease in Central America...
  12. Chagas Disease Confirmatory Assay
    Andrew Levin; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE Chagas disease has become a significant threat to public health and to the blood supply, both in the U.S...
  13. Human serum carbonyl proteome in cardiovascular diseases
    Nisha Jain Garg; Fiscal Year: 2010
    ..74 million disability-adjusted life years per year. By the time most patients are diagnosed with Chagas disease, heart dysfunction has been progressing for many years...
  14. Validation and development of trypanosomal phosphodiesterase inhibitors for treat
    Michael P Pollastri; Fiscal Year: 2013
    ..cruzi (which causes Chagas disease) have been recently elucidated, a number of potentially therapeutically-relevant molecular targets have been ..
  15. Confirmatory Immunoblot Test for Chagas'Disease
    ANDREW E LEVIN; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Chagas disease has become a significant threat to public health and to the blood supply, both in the U.S...
  16. Global sumoylation analysis in Trypanosoma brucei
    David A Campbell; Fiscal Year: 2010
    ..of medical importance, including the causative agents of human leishmaniasis, African trypanosomiasis and Chagas disease. These organisms employ an unusual mechanism of gene expression that involves polycistronic transcription of ..
  17. Pathogenesis of Trypanosoma cruzi infection
    Roberto Docampo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Morbidity and mortality associated with Chagas disease in Latin America exceed better-known conditions such as malaria, tuberculosis, or AIDS. Millions of people are affected by this trypanosomiasis...
  18. ETIOLOGY AND PATHOGENESIS OF PEMPHIGUS
    Luis A Diaz; Fiscal Year: 2013
    ..Moreover, the sera of patients with leishmaniasis, Chagas disease and onchocerciasis, where these insects are involved as carriers of parasites, possess anti-Dsg1 antibodies...
  19. Tulane-Xavier Minority Training in International Health
    Richard A Oberhelman; Fiscal Year: 2013
    ..tuberculosis in Peru, interventions to reduce maternal and perinatal morbidity and mortality in Argentina, Chagas disease in Mexico, clinical trials of new antimalarial drugs in Mali, Lassa Fever and tropical diseases in Sierra ..
  20. Broad Detection of Infectious Agents in Blood by Microarrays and Deep Sequencing
    CHARLES YEN CHIU; Fiscal Year: 2013
    ..accuracy) for detection of pathogens associated with the most common bloodborne infections, including malaria, Chagas disease, HIV, hepatitis B/C, and dengue virus...
  21. Ultraviolet light sensing by cryptochrome
    Todd C Holmes; Fiscal Year: 2013
    ..Other CRY sequences will become available in the near future for testing the insect vectors for Chagas disease and typhus...
  22. Characterization of Potassium Channels in the Human Parasite Trypanosoma Cruzi
    Veronica Jimenez; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chagas disease is a zoonotic tropical pathology, caused by the protozoan parasite Trypanosoma cruzi. Endemic in Latin America, it is one of the leading causes of congestive heart failure in the world...
  23. Trypanosoma cruzi Antioxidant Systems, Virulence and Parasite Persistence in Chag
    Rafael Radi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chagas disease caused by the parasitic protozoan Trypanosoma cruzi remains a major public health concern in Latin America and is now spreading worldwide...
  24. Improving blood safety and HIV testing in Brazil: a randomized controlled trial
    THELMA THEREZINHA GONCALEZ; Fiscal Year: 2013
    ..include differences in prevalence of transfusion-transmitted infections (HIV, HCV, HBV, syphilis, HTLV I/II, Chagas disease), donor motivations (e.g., test-seeking vs...
  25. Deep sequence profiling of gRNA transcriptomes in two stages of Trypanosoma bruce
    DONNA JAY KOSLOWSKY; Fiscal Year: 2012
    ..diseases targeted for attention by the World Health Organization (WHO);Leishmaniasis, sleeping sickness and Chagas disease. Together these parasites affect approximately 550 million people in the developing world...
  26. Space Renovation for New Research Center for the Neglected Diseases of Poverty
    John Williams; Fiscal Year: 2010
    ..Also, extensive research is underway to study the major U.S. NIPs including toxocariasis, toxoplasmosis, and Chagas disease, currently affecting millions of African Americans and Hispanic Americans...
  27. Early Detection of Congenital Chagas Disease
    Robert H Gilman; Fiscal Year: 2013
    ..Approximately 5% of T. cruzi infected women give birth to infected infants at risk of clinically manifest Chagas disease at birth, shortly after birth or later in life...
  28. Global gene expression analysis of Trypanosoma cruzi under hyperosmotic stress
    Roberto Docampo; Fiscal Year: 2012
    ..Juan J. Cazzulo, as an extension of NIH Grant 1R01 AI068647. Chemotherapy of Chagas disease is restricted to drugs with relatively high toxicity and limited efficacy...
  29. Testing DNA Vaccine Against T. cruzi in Large Animal Model (Dogs)
    Nisha Jain Garg; Fiscal Year: 2010
    SUMMARY The protozoan parasite T. cruzi-induced Chagas disease is the prime cause of death in young adults in endemic areas of the American continent and results in >50,000 deaths, 1 million new cases, and loss of 2...
  30. Structural Requirements for Sterol 14alpha-Demethylases
    Galina I Lepesheva; Fiscal Year: 2013
    ..four test systems: protozoa themselves, human cells, human cells infected with protozoa and mouse models for Chagas disease. Second, we will test these scaffolds and their derivatives as potential drugs for treatment of infection by ..
  31. Mechanistic and structural studies of eukaryotic UDP-galactopyranose mutases
    Pablo Sobrado; Fiscal Year: 2013
    ..for the development of chemotherapeutics for the treatment of fungal infections and neglected diseases such as Chagas disease. ) PUBLIC HEALTH RELEVANCE: UDP-galactopyranose mutase (UGM) catalyzes a key step in the biosynthesis of ..
  32. CHADSS: Chagas Disease Scan Study
    Jamary Oliveira-Filho; Fiscal Year: 2013
    ..One of the main contributors to stroke incidence is the highly prevalent Chagas disease, a parasitic infection affecting an estimated 18 million individuals and a major cause of heart failure in ..
  33. Kinetoplastid SL RNA biogenesis
    David A Campbell; Fiscal Year: 2013
    ..which includes the parasitic protozoa responsible for leishmaniasis, African Sleeping Sickness, and Chagas Disease. The focus is on the genesis and function of the spliced leader (SL) RNA, a small RNA that contributes the 5&..
  34. Characterization of Potassium Channels in the Human Parasite Trypanosoma Cruzi
    Veronica Jimenez; Fiscal Year: 2013
    Abstract Chagas disease is a zoonotic tropical pathology, caused by the protozoan parasite Trypanosoma cruzi. Endemic en Latin America, it is one of the leading causes of congestive heart failure in the world...
  35. Xenodiagnosis of Lyme Disease
    Linden T Hu; Fiscal Year: 2012
    ..Xenodiagnosis has been used for other difficult to diagnose diseases such as Chagas disease. Organisms may be specifically adapted to their natural vector and xenodiagnosis can sometimes definitively ..
  36. HTS assay for the intracellular stages of T. cruzi, the vector of Chagas disease
    Juan Engel; Fiscal Year: 2009
    ..cruzi, and to screen compound libraries from industrial and academic sources. This HTS assay will greatly facilitate drug discovery efforts for Chagas'disease. ..
  37. Structures and selective inhibition of tRNA synthetases from pathogenic protozoa
    WILHELMUS HOL; Fiscal Year: 2009
    ..These are related parasites which cause sleeping sickness, Chagas disease, and leishmaniasis, respectively, and are responsible for millions of infections and nearly one million deaths ..
  38. Selective inhibition of tRNA synthetases from pathogenic protozoa
    WILHELMUS G J HOL; Fiscal Year: 2013
    ..These are related parasites which cause sleeping sickness, Chagas disease, and leishmaniasis, respectively, and are responsible for tens of millions of infections annually, mainly in ..
  39. STRUCTURE AND MECHANISM OF PROTEIN PRENYLTRANSFERASES
    Lorena S Beese; Fiscal Year: 2013
    ..and GGTase inhibitors (FTls and GGTIs) show promise for treatment of parasitics infections including malaria, Chagas disease, African sleeping sickness, Leishmania and fungal infections such as Candida albicans, which can be life-..
  40. Broad spectrum antivirals targeting envelope proteolysis and viral uncoating
    Graham Simmons; Fiscal Year: 2013
    ..lead compounds, one of which is being developed by members of our consortium as a therapeutic agent for Chagas disease. We propose to refine these compounds in order to increase their drug-like properties and optimize their ..
  41. Training in Tropical and Emerging Global Diseases
    Boris Striepen; Fiscal Year: 2013
    ..The research systems available for study include malaria, intestinal protozoans, Chagas disease, African sleeping sickness, leishmaniasis, toxoplasmosis, Ichthyophthirius multifiliis, schistosomiasis, ..
  42. 2010 Biology of Host-Parasite Interactions Gordon Research Conference
    L David Sibley; Fiscal Year: 2010
    ..The focus will be on the identification, validation, and characterization of new therapeutic targets and strategies to combat human infectious diseases. ..
  43. Validating novel drug targets in Trypanosoma cruzi polyamine biosynthesis
    Michael C Gretes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma cruzi is the protozoan trypanosomatid parasite that causes Chagas disease, which affects 10-12 million overwhelmingly poor people in 22 Latin American countries and an estimated 300,000 in ..
  44. New molecular techniques for T. cruzi
    Huan Huang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma cruzi (T. cruzi) causes Chagas Disease (e.g., American Trypanosomiasis) in humans...
  45. The ecology and epidemiology of Chagas disease in urban and rural communities
    CESAR GABRIEL NAQUIRA; Fiscal Year: 2011
    ..of vectors and parasite into the city of Arequipa itself allows analysis of the trend of urbanization of Chagas disease transmission and identification of modifications necessary to eliminate the vector from the urban environment...
  46. Role of DNA Ligands in Innate Immunity
    Nilay Dey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chagas disease (CHD) caused by Trypanosoma cruzi (T. cruzi) is endemic in Latin America and an emerging disease in the US and other developed countries. The overall prevalence of human T...
  47. Oxidative Response Networks in Chagasic Cardiomyopathy
    Nisha Jain Garg; Fiscal Year: 2013
    ..we plan to investigate the critical importance of mitochondrial dysfunction and oxidative stress in human Chagas disease severity. Our central hypothesis is that infection by T...
  48. Ultrahigh Resolution Optical Barcode
    ROBERT C HAUSHALTER; Fiscal Year: 2011
    ..along with the MARS, and (5) test the completely functional system by comparing our diagnostic assay for Chagas disease against a known diagnostic assay using Luminex...
  49. Transmission-blocking live vaccine for Chagas disease
    Rick L Tarleton; Fiscal Year: 2013
    ..Additionally, such a vaccine could be delivered in an oral form - making widespread vaccination of animals quite easy. ..
  50. Sterol Biosynthesis in Trypanosomatid Parasites
    Frederick Buckner; Fiscal Year: 2004
    The long-term objective of this project is to discover new therapeutics for leishmaniasis and Chagas disease. These infectious diseases are caused by parasitic protozoa of the family, Trypanoisomatidae...
  51. Structure-Aided Design of CYP51 Inhibitors for Treatment of Parasitic Infections
    Larissa M Podust; Fiscal Year: 2013
    ..that target the sterol biosynthesis pathway in Trypanosoma cruzi, agent of the neglected tropical disease Chagas Disease. No vaccine exists for this infection nor is one likely to become available any time soon...
  52. Exploiting the cAMP pathway in Chagas Disease Therapy
    Daniel L Altschuler; Fiscal Year: 2013
    ..e. Chagas disease. Chagas disease is a life-threatening illness caused by the protozoan parasite Trypanosoma cruzi...
  53. Regional Training Center for Tropical Disease Research in Quito-Ecuador
    Mario J Grijalva; Fiscal Year: 2013
    ..overall objective of this proposal is to obtain biological and clinical information that will improve current Chagas disease control efforts in Ecuador, while implementing a sound and sustainable training program in infectious disease ..
  54. Genetic Epidemiology of Chagas Disease Progression
    SARAH A WILLIAMS-BLANGERO; Fiscal Year: 2012
    b>Chagas disease affects 17 million people and a further 100 million people are at risk for infection with Trypanosoma cruzi, the parasitic cause of Chagas disease, throughout Latin America...
  55. T. cruzi molecular targets for vector paratransgenesis
    Ravi V Durvasula; Fiscal Year: 2010
    b>Chagas disease afflicts over 12 million people in Central and South America...
  56. Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease
    James H McKerrow; Fiscal Year: 2013
    ....
  57. GENETIC ANALYSIS OF PURINE METABOLISM IN LEISHMANIA DONO
    Buddy Ullman; Fiscal Year: 2007
    ..coli that overexpress hgprt genes, and[unreadable] intact parasites. ..
  58. Identification and Validation of Targets of Phenotypic High Throughput Screening
    Sean Ekins; Fiscal Year: 2013
    ..by applicant): Identification and Validation of Targets of Phenotypic High Throughput Screening Hits for Chagas Disease Project Summary Nearly 10 million people in Latin America are infected with the eukaryotic parasite ..
  59. STRUCTURE AND SYNTHESIS OF DNA
    Robert E Jensen; Fiscal Year: 2013
    ..study is Trypanosoma brucei that causes African sleeping sickness, although related parasites with kDNA cause Chagas disease and Leishmaniasis...
  60. Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission
    Michael Zachary Levy; Fiscal Year: 2012
    b>Chagas disease, caused by the unicellular parasite Trypanosoma cruzi, is a preventable disease. Nevertheless more people in the Americas die from Chagas disease than any other parasitic infection...
  61. Sao Paulo- MInas Gerais Neglected Tropical Disease Research Center for Biomarker
    Ester Cerdeira Sabino; Fiscal Year: 2013
    ..of the Public Health System in the State of Minas by enrolling and collecting blood samples from 2000 Chagas disease patients...
  62. Interhemispheric Research/Training in Infectious Disease
    HERBERT BERNARD TANOWITZ; Fiscal Year: 2013
    ..e., histoplasmosis, sporotrichosis) parasitic diseases (Chagas disease, toxoplasmosis and malaria) and bacterial diseases (legionnaire's disease and tuberculosis) which are ..
  63. Development of T cell memory in human Trypanosoma cruzi infection
    Susana Laucella; Fiscal Year: 2013
    ..The frequencies of T. cruzi-specific T cells were also found to correlate with the severity of chronic Chagas disease. Based upon these results, it may be hypothesized that in the face of the persistence of stimulating antigen ..
  64. GUIDE: Genomic Uses in Infectious Diseases and Epidemics
    Jeffrey P Kahn; Fiscal Year: 2013
    ..g., HIV, HPV, tuberculosis), and broaden our reach to include additional categories of infectious disease such as insect-borne (e.g., malaria, Dengue fever, Chagas disease) and, perhaps, food-borne infections.
  65. Chemokine-endothelin interaction & Chagas' disease
    Herbert Tanowitz; Fiscal Year: 2006
    ..The research will be performed primarily at the Brazil site in collaboration with Herbert Tanowitz at the US site as extension of NIH Grant AI-12770 [unreadable] [unreadable]..
  66. MUTATIONAL ANALYSIS OF A PARASITE PURINE SALVAGE ENZYME
    SYDNEY CRAIG; Fiscal Year: 2001
    ..abstract_text> ..
  67. ROLE OF CALRETICULIN IN CALCIUM HOMEOSTASIS OF T. CRUZI
    Roberto Docampo; Fiscal Year: 2002
    ..Our specific aims are: specific aim 1, to investigate the levels and location of calreticulin in T. cruzi different stages, and specific aim 2, to investigate the role of calreticulin in Ca2+ homeostasis in T. cruzi ..
  68. Development of Dynamic Combinatorial Libraries for Cruzipain Inhibition
    Peter Wipf; Fiscal Year: 2009
    ..2. Identify compounds with biological significance for Chagas disease: (a) test the libraries using the enzyme cruzipain in order to identify inhibitors by changes in the library ..
  69. ACIDOCALCISOMES IN TRYPANOSOMA CRUZI
    Roberto Docampo; Fiscal Year: 2002
    ..cruzi H+-pyrophosphatase; specific aim 3: investigation of the role of acidocalcisomes in intracellular Ca2+ and pH homeostasis. ..