toxoplasmosis

Summary

Summary: The acquired form of infection by Toxoplasma gondii in animals and man.

Articles from Journal RESEARCH

Top Publications

  1. pmc Toxoplasma gondii: from animals to humans
    A M Tenter
    Institut für Parasitologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559, Hannover, Germany
    Int J Parasitol 30:1217-58. 2000
  2. ncbi Toxoplasmosis
    J G Montoya
    Department of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Lancet 363:1965-76. 2004
  3. pmc Epidemiology of and diagnostic strategies for toxoplasmosis
    Florence Robert-Gangneux
    Service de Parasitologie, Faculté de Médecine et Centre Hospitalier Universitaire de Rennes, Rennes, France
    Clin Microbiol Rev 25:264-96. 2012
  4. ncbi Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Building 1001, BARC East, Beltsville, MD 20705 2350, USA
    Parasitology 139:1375-424. 2012
  5. pmc Toxoplasmosis: A history of clinical observations
    Louis M Weiss
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Parasitol 39:895-901. 2009
  6. pmc Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii
    Michael S Behnke
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, USA
    PLoS ONE 5:e12354. 2010
  7. pmc Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America
    Asis Khan
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Parasitol 41:645-55. 2011
  8. pmc Toxoplasma gondii effectors are master regulators of the inflammatory response
    Mariane B Melo
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Trends Parasitol 27:487-95. 2011
  9. pmc Immune response and immunopathology during toxoplasmosis
    Christopher D Dupont
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Immunopathol 34:793-813. 2012
  10. ncbi Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host
    Jeroen P J Saeij
    Stanford University School of Medicine, Department of Microbiology and Immunology, Fairchild Building D305, 300 Pasteur Drive, Stanford, CA 94305 5124, USA
    Trends Parasitol 21:476-81. 2005

Detail Information

Articles from Journal RESEARCH1

Publications301 found, 100 shown here

  1. pmc Toxoplasma gondii: from animals to humans
    A M Tenter
    Institut für Parasitologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559, Hannover, Germany
    Int J Parasitol 30:1217-58. 2000
    b>Toxoplasmosis is one of the more common parasitic zoonoses world-wide...
  2. ncbi Toxoplasmosis
    J G Montoya
    Department of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Lancet 363:1965-76. 2004
    ..Diagnosis of toxoplasmosis can be established by direct detection of the parasite or by serological techniques...
  3. pmc Epidemiology of and diagnostic strategies for toxoplasmosis
    Florence Robert-Gangneux
    Service de Parasitologie, Faculté de Médecine et Centre Hospitalier Universitaire de Rennes, Rennes, France
    Clin Microbiol Rev 25:264-96. 2012
    ..In particular, we provide critical information on diagnostic methods according to the patient's background and discuss the implementation of screening tools for congenital toxoplasmosis according to health policies.
  4. ncbi Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Building 1001, BARC East, Beltsville, MD 20705 2350, USA
    Parasitology 139:1375-424. 2012
    ..The burden of clinical toxoplasmosis in humans is considered to be very high...
  5. pmc Toxoplasmosis: A history of clinical observations
    Louis M Weiss
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Parasitol 39:895-901. 2009
    ..Fifteen years after the description of T. gondii by Nicolle and Manceaux a fatal case of toxoplasmosis in a child was reported by Janků. In 1939 Wolf, Cowen and Paige were the first to conclusively identify T...
  6. pmc Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii
    Michael S Behnke
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, USA
    PLoS ONE 5:e12354. 2010
    ....
  7. pmc Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America
    Asis Khan
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Parasitol 41:645-55. 2011
    ..Collectively, the archetypal type 2 has been associated with clonal expansion of a small number of lineages in the North, as a consequence of separate but infrequent genetic crosses with several different parental lines...
  8. pmc Toxoplasma gondii effectors are master regulators of the inflammatory response
    Mariane B Melo
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Trends Parasitol 27:487-95. 2011
    ..We speculate that combinations of these effectors present in certain Toxoplasma strains work to maintain an optimal parasite burden in different hosts to ensure parasite transmission...
  9. pmc Immune response and immunopathology during toxoplasmosis
    Christopher D Dupont
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Immunopathol 34:793-813. 2012
    ..we will review current knowledge of the innate and adaptive immune responses required for resistance to toxoplasmosis, the events that lead to the development of immunopathology, and the natural regulatory mechanisms that limit ..
  10. ncbi Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host
    Jeroen P J Saeij
    Stanford University School of Medicine, Department of Microbiology and Immunology, Fairchild Building D305, 300 Pasteur Drive, Stanford, CA 94305 5124, USA
    Trends Parasitol 21:476-81. 2005
    ..Many studies have investigated the ability of T. gondii to manipulate its host but few have examined directly whether the three lineages differ in this ability...
  11. pmc Toxoplasma gondii infection in humans in China
    Peng Zhou
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, P R China
    Parasit Vectors 4:165. 2011
    b>Toxoplasmosis is a zoonotic infection of humans and animals, caused by the opportunistic protozoan Toxoplasma gondii, a parasite belonging to the phylum Apicomplexa...
  12. ncbi The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii
    Jonathan C Howard
    Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
    Curr Opin Microbiol 14:414-21. 2011
    ..Thus these two mechanisms form the two poles of a dynamic host-pathogen virulence-resistance relationship with interesting and accessible properties...
  13. ncbi Immunology of Toxoplasma gondii
    Melba Munoz
    Charite Medical School Berlin Microbiology and Hygiene, Berlin, Germany
    Immunol Rev 240:269-85. 2011
    ..Systemic and local immune responses in different models of infection are discussed, and a separate chapter introduces commonly used animal models of infection...
  14. ncbi Foodborne toxoplasmosis
    Jeffrey L Jones
    Parasitic Diseases Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 55:845-51. 2012
    b>Toxoplasmosis can be due to congenital infection or acquired infection after birth and is one of the leading illnesses associated with foodborne hospitalizations and deaths...
  15. ncbi Toxoplasma gondii infection in the United States, 1999 2004, decline from the prior decade
    Jeffrey L Jones
    Division of Parasitic Diseases, National Center for Zoonotic, Vectorborne, and Enteric Diseases, CCID, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Am J Trop Med Hyg 77:405-10. 2007
    ..1% to 9.0% (P < 0.001) from NHANES III to NHANES 1999-2004 among U.S.-born persons ages 12-49 years. Although T. gondii infects many persons in the U.S., the prevalence has declined in the past decade...
  16. ncbi Control of the risk of human toxoplasmosis transmitted by meat
    Aize Kijlstra
    Animal Sciences Group, Wageningen UR, P O Box 65, 8200 AB Lelystad, The Netherlands
    Int J Parasitol 38:1359-70. 2008
    ..Recent calculations of the disease burden of toxoplasmosis rank this foodborne disease at the same level as salmonellosis or campylobacteriosis...
  17. ncbi Toxoplasma gondii infection in humans and animals in the United States
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, MD 20705 2350, USA
    Int J Parasitol 38:1257-78. 2008
    ..Seroprevalence of T. gondii in humans and pigs is declining. Modes of transmission, epidemiology and environmental contamination with oocysts on land and sea are discussed...
  18. pmc CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain
    Nathalie Courret
    Departement des Maladies Infectieuses, Institut Cochin, Institut National de la Santé et de la Recherche Médicale U567 Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, 22 rue Mechain, 75014 Paris, France
    Blood 107:309-16. 2006
    ..gondii zoites hijacked CD11b+ leukocytes to reach the brain extravascular space...
  19. pmc Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation
    Kirk D C Jensen
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell Host Microbe 9:472-83. 2011
    ..Thus, polymorphisms in determinants that modulate macrophage activation influence the ability of Toxoplasma to establish a chronic infection...
  20. pmc Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection
    E Y Denkers
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    Clin Microbiol Rev 11:569-88. 1998
    ..While part of the clinical manifestations of toxoplasmosis results from direct tissue destruction by the parasite, inflammatory cytokine-mediated immunopathologic ..
  21. pmc A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3
    Masahiro Yamamoto
    Department of Microbiology and Immunology, Graduate School of Medicine, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 206:2747-60. 2009
    ..These results formally establish an essential and direct requirement of ROP16 in parasite-induced Stat3 activation and the significance of a single amino acid replacement in the function of type II ROP16...
  22. ncbi Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis
    Georgios Pappas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Int J Parasitol 39:1385-94. 2009
    ..for humans refers mainly to primary infection during pregnancy, resulting in abortion/stillbirth or congenital toxoplasmosis. The authors sought to evaluate the current global status of T...
  23. pmc Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli
    M M Heimesaat
    Institut für Mikrobiologie und Hygiene, Charite, Universitatsmedizin Berlin, Campus Charite Mitte, Dorotheenstr 96, D 10117 Berlin, Germany
    Gut 56:941-8. 2007
    ..In the course of inflammatory bowel diseases (IBD) and acute murine ileitis following peroral Toxoplasma gondii infection, commensal Escherichia coli accumulate at inflamed mucosal sites and aggravate small intestinal immunopathology...
  24. pmc Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease
    Melanie Craven
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 7:e41594. 2012
    ..We sought to examine the dynamics of the relationship between inflammation, the ileal microbiome, and host genetics in murine models of ileitis...
  25. pmc Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring
    D G Mordue
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 190:1783-92. 1999
    ....
  26. pmc Identification of tissue cyst wall components by transcriptome analysis of in vivo and in vitro Toxoplasma gondii bradyzoites
    Kerry R Buchholz
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305 5124, USA
    Eukaryot Cell 10:1637-47. 2011
    ..Thus, we report the first analysis of the transcriptomes of in vitro and in vivo bradyzoites and identify two new protein components of the Toxoplasma tissue cyst wall...
  27. ncbi Toxoplasma gondii: epidemiology, feline clinical aspects, and prevention
    Stacey A Elmore
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Trends Parasitol 26:190-6. 2010
    ..Because of their fastidious nature, the passing of non-infective oocysts, and the short duration of oocyst shedding, direct contact with cats is not thought to be a primary risk for human infection...
  28. ncbi The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
    Alejandro Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104, USA
    Immunity 19:645-55. 2003
    ....
  29. pmc Incidence of adult brain cancers is higher in countries where the protozoan parasite Toxoplasma gondii is common
    Frederic Thomas
    IRD, MIVEGEC UMR CNRS IRD UM1, Montpellier, France
    Biol Lett 8:101-3. 2012
    ..gondii prevalence in our dataset (4-67%). These results, though correlational, suggest that T. gondii should be investigated further as a possible oncogenic pathogen of humans...
  30. ncbi Waterborne toxoplasmosis--recent developments
    J L Jones
    Division of Parasitic Diseases, National Center for Zoonotic, Vectorborne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, MS F22, Chamblee, GA 30341, USA
    Exp Parasitol 124:10-25. 2010
    ..The present paper examines the possible importance of T. gondii transmission by water...
  31. ncbi Outbreak of toxoplasmosis associated with municipal drinking water. The BC Toxoplasma Investigation Team
    W R Bowie
    Division of Infectious Diseases, University of British Columbia, Vancouver, Canada
    Lancet 350:173-7. 1997
    Outbreaks of toxoplasmosis are recognised infrequently. In March, 1995, a sudden increase of serologically diagnosed cases of acute toxoplasmosis was noted in the Greater Victoria area of British Columbia, Canada...
  32. ncbi Toxoplasmosis - a waterborne zoonosis
    J P Dubey
    Animal Parasitic Diseases Laboratory, United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, BARC East, Building 1001, Beltsville, MD 20705 2350, USA
    Vet Parasitol 126:57-72. 2004
    ..The present paper reviews information on the biology of oocyst-induced infections of T. gondii in humans and animals and examines possible importance of transmission by water...
  33. pmc The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5
    Clett Erridge
    Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
    PLoS ONE 5:e9125. 2010
    ..We aimed to establish if intestinal concentrations of proinflammatory bacterial ligands of TLR2, TLR4, or TLR5 may be altered in murine IBD models, and to characterize which of the major bacterial groups may contribute to each signal...
  34. ncbi Risk factors for Toxoplasma gondii infection in the United States
    Jeffrey L Jones
    Division of Parasitic Diseases, National Center for Zoonotic, Vectorborne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Clin Infect Dis 49:878-84. 2009
    b>Toxoplasmosis can cause severe ocular and neurological disease. We sought to determine risk factors for Toxoplasma gondii infection in the United States.
  35. pmc Toxoplasma MIC2 is a major determinant of invasion and virulence
    My Hang Huynh
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    PLoS Pathog 2:e84. 2006
    ..the loss of helical gliding motility, and the inability to support lethal infection in a murine model of acute toxoplasmosis. Survival of mice infected with MIC2-deficient parasites correlated with lower parasite burden in infected ..
  36. pmc Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses
    Lucia Peixoto
    Department of Biology and Penn Genome Frontiers Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Host Microbe 8:208-18. 2010
    ..These results highlight the value of integrative genomic approaches in prioritizing candidates for functional validation...
  37. ncbi Moving towards an integrated approach to molecular detection and identification of Toxoplasma gondii
    C Su
    Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, USA
    Parasitology 137:1-11. 2010
    ..of Toxoplasma gondii is important for the diagnosis and epidemiological studies of the zoonotic disease toxoplasmosis. In the past 2 decades, molecular methods based on a variety of genetic markers have been developed, each with ..
  38. ncbi Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii
    Audra J Charron
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 115:3049-59. 2002
    ..Together, these studies underscore the ability of Toxoplasma gondii to divert and use lipid resources from its host, a process that may contribute to the biogenesis of parasite membranes...
  39. ncbi Genetic characterization of Toxoplasma gondii isolates from China
    Peng Zhou
    College of Veterinary Medicine, South China Agricultural University, 483 Wushan Street, Tianhe District, Guangzhou, Guangdong Province 510642, PR China
    Parasitol Int 58:193-5. 2009
    ..gondii, as well as for the prevention and control of T. gondii infections in humans and animals in China...
  40. pmc Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens
    Zijiang Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Host Microbe 4:458-69. 2008
    ....
  41. ncbi Genotype of 88 Toxoplasma gondii isolates associated with toxoplasmosis in immunocompromised patients and correlation with clinical findings
    Daniel Ajzenberg
    Centre Hospitalier Universitaire, Amiens, France
    J Infect Dis 199:1155-67. 2009
    ..Lack of specific anti-Toxoplasma treatment, pulmonary toxoplasmosis, and involvement of multiple organs were the 3 main risk factors associated with death for this patient group...
  42. ncbi Recent expansion of Toxoplasma through enhanced oral transmission
    C Su
    Department of Molecular Microbiology, Washington University, St Louis, MO 63110, USA
    Science 299:414-6. 2003
    ..Thus, changes in complex life cycles can occur rapidly and can profoundly influence pathogenicity...
  43. pmc The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis
    Miroslava Berenreiterová
    Biology Section, Faculty of Science, Charles University in Prague, Praha, Czech Republic
    PLoS ONE 6:e28925. 2011
    ..Paradoxically, the distribution of the parasite in the brain has received only scant attention...
  44. ncbi Toxoplasma gondii infection in the United States: seroprevalence and risk factors
    J L Jones
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Am J Epidemiol 154:357-65. 2001
    ..gondii. Most women of childbearing age in the United States are susceptible to acute infection and should be educated about ways to minimize exposure to T. gondii...
  45. pmc CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites
    Mona Mashayekhi
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Immunity 35:249-59. 2011
    ..These results reveal that the function of CD8α(+) DCs extends beyond a role in cross-presentation and includes a critical role for activation of innate immunity through IL-12 production during T. gondii infection...
  46. pmc The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens
    Oliver Liesenfeld
    Institute of Microbiology and Hygiene, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e20568. 2011
    ..Taken together, our results implicate Irga6 in the control of infection with T. gondii and further highlight the importance of the IRG system for resistance to this pathogen...
  47. pmc The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response
    Wendy Niedelman
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    PLoS Pathog 8:e1002784. 2012
    ..These findings suggest that ROP18 and ROP5 have specifically evolved to block the IRGs and are unlikely to have effects in species that do not have the IRG system, such as humans...
  48. ncbi The immunobiology of the innate response to Toxoplasma gondii
    Catherine M Miller
    Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, PO Box 123, Broadway, NSW 2007, Australia
    Int J Parasitol 39:23-39. 2009
    ....
  49. pmc Toxoplasma gondii and other risk factors for schizophrenia: an update
    E Fuller Torrey
    The Stanley Medical Research Institute, 8401 Connecticut Avenue, Suite 200, Chevy Chase, MD 20815, USA
    Schizophr Bull 38:642-7. 2012
    ..01), specific genetic polymorphisms (OR 1.09-1.24; 95% CI 1.06-1.45), birth seasonality (OR 1.07-1.95; 95% CI 1.05-2.91), maternal exposure to influenza (RR 1.05; 95% CI 0.98-1.12), or prenatal stress (RR 0.98-1.00; 95% CI 0.85-1.16)...
  50. ncbi Toxoplasma and schizophrenia
    R H Yolken
    Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4933, USA
    Parasite Immunol 31:706-15. 2009
    ..gondii, (ii) some individuals with adult toxoplasmosis develop psychotic symptoms similar to those of schizophrenia, (iii) epidemiologically, there are many ..
  51. pmc Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6
    Yi Ching Ong
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 285:28731-40. 2010
    ..Furthermore, ROP16 co-immunoprecipitates with STAT6 from infected cells. Taken together, these data strongly suggest that STAT6 is a direct substrate for ROP16 in vivo...
  52. ncbi The probable relation between Toxoplasma gondii and Parkinson's disease
    Ozlem Miman
    Afyon Kocatepe University, Faculty of Medicine, Department of Microbiology, Izmir Street, 5 km, Afyonkarahisar, Turkey
    Neurosci Lett 475:129-31. 2010
    ..Neuroinflammatory mechanisms might contribute to the cascade of events leading to neuronal degeneration. Toxoplasmosis can be associated with various neuropsychiatric disorders...
  53. ncbi Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii
    Markus M Heimesaat
    Institut für Mikrobiologie und Hygiene, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin and Campus Mitte, Hindenburgdamm 27, D 12203 Berlin, Germany
    J Immunol 177:8785-95. 2006
    ..Thus, pathogen-induced acute ileitis may prove useful to study bacteria-host interactions in small intestinal inflammation and to test novel therapies based on modulation of gut flora...
  54. pmc Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection
    Allison L Bierly
    Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    J Immunol 181:8485-91. 2008
    ..We hypothesize that Toxoplasma exploits pDCs as Trojan horses, targeting them for early infection, suppressing their cytokine effector function, and using them for dissemination within the host...
  55. ncbi Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps
    L David Sibley
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, 63130, USA
    Annu Rev Microbiol 62:329-51. 2008
    ..gondii and has resulted in most lineages sharing a highly pathogenic nature. Understanding the factors that have shaped the population structure of T. gondii has implications for the emergence and transmission of human pathogens...
  56. pmc Toxoplasma gondii and schizophrenia
    E Fuller Torrey
    Stanley Medical Research Institute, Bethesda, Maryland 20814 2142, USA
    Emerg Infect Dis 9:1375-80. 2003
    ..gondii in cell culture. Establishing the role of T. gondii in the etiopathogenesis of schizophrenia might lead to new medications for its prevention and treatment...
  57. ncbi Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring
    Alan S Brown
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 23, New York, NY 10032, USA
    Am J Psychiatry 162:767-73. 2005
    The authors examined the relationship between maternal antibody to toxoplasmosis and the risk of schizophrenia and other schizophrenia spectrum disorders in offspring. Toxoplasmosis is known to adversely affect fetal brain development.
  58. ncbi Kiss and spit: the dual roles of Toxoplasma rhoptries
    John C Boothroyd
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Nat Rev Microbiol 6:79-88. 2008
    ..Here, we discuss these recent findings and use them to propose a model in which an expansion of host range is a major force that drives rhoptry-protein evolution...
  59. ncbi Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination
    Henrik Lambert
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Cell Microbiol 8:1611-23. 2006
    ..Altogether, these findings show that Toxoplasma is able to subvert the regulation of host cell motility and likely exploits the host's natural pathways of cellular migration for parasite dissemination...
  60. pmc Host cell manipulation by the human pathogen Toxoplasma gondii
    J Laliberte
    Department of Microbiology and Immunology, University of Michigan Medical School, 1150 West Medical Center Drive, 5751 Medical Science Building II, Ann Arbor, Michigan 48109 0620, USA
    Cell Mol Life Sci 65:1900-15. 2008
    ..In this review we discuss these recent developments in understanding how Toxoplasma achieves widespread success as a human and animal parasite by manipulating its host...
  61. ncbi Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries
    M E Grigg
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124, USA
    Science 294:161-5. 2001
    ..Thus, sexual recombination, by combining polymorphisms in two distinct and competing clonal lines, can be a powerful force driving the natural evolution of virulence in this highly successful pathogen...
  62. pmc Fatal attraction in rats infected with Toxoplasma gondii
    M Berdoy
    Oxford University Veterinary Services, UK
    Proc Biol Sci 267:1591-4. 2000
    ..We discuss our results in terms of their potential implications both for the epidemiology of toxoplasmosis and the neurological basis of anxiety and cognitive processes in humans and other mammals.
  63. ncbi Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR
    W L Homan
    Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Int J Parasitol 30:69-75. 2000
    ..With the quantitative competitive-PCR, furthermore, we could confirm the copy number of the 529bp fragment in tachyzoites and estimate the number of bradyzoites per cyst...
  64. pmc Oral oocyst-induced mouse model of toxoplasmosis: effect of infection with Toxoplasma gondii strains of different genotypes, dose, and mouse strains (transgenic, out-bred, in-bred) on pathogenesis and mortality
    J P Dubey
    United States Department of Agriculture, Animal Natural Resources Institute, Animal Parasitic Disease Laboratory, BARC East, Beltsville, MD 20705 2350, USA
    Parasitology 139:1-13. 2012
    ..In the present study, pathogenesis of toxoplasmosis was studied in mice of different strains, including Human Leukocyte Antigen (HLA) transgenic mice infected ..
  65. ncbi New antibacterials for the treatment of toxoplasmosis; a patent review
    Juan Bautista Rodriguez
    Universidad de Buenos Aires, Química Orgánica and UMYMFOR CONICET FCEyN, Facultad de Ciencias Exactas y Naturales, Pab 2, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina
    Expert Opin Ther Pat 22:311-33. 2012
    Toxoplasma gondii is an opportunistic protozoan parasite responsible for toxoplasmosis. T. gondii is able to infect a wide range of hosts, particularly humans and warm-blooded animals...
  66. pmc Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
    J P J Saeij
    Department of Microbiology and Immunology, Fairchild Building D305, 300 Pasteur Drive, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Nature 445:324-7. 2007
    ..Our findings provide a new mechanism for how an intracellular eukaryotic pathogen can interact with its host and reveal important differences in how different Toxoplasma lineages have evolved to exploit this interaction...
  67. pmc Seroprevalence and risk factors for Toxoplasmosis in HIV infected and non-infected individuals in Bahir Dar, Northwest Ethiopia
    Fisseha Walle
    Department of Immunology and Hematology, Bahir Dar Regional Health Research Laboratory, Bahir Dar, Ethiopia
    Parasit Vectors 6:15. 2013
    b>Toxoplasmosis, a zoonotic disease distributed worldwide, is an infection caused by the ubiquitous obligatory intracellular coccidian protozoan organism, Toxoplasma gondii...
  68. ncbi Serotyping of Toxoplasma gondii infections in humans using synthetic peptides
    Jiang Ti Kong
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Infect Dis 187:1484-95. 2003
    To determine whether the characteristics of disease due to Toxoplasma gondii (toxoplasmosis) are dependent on the infecting strain, we have developed an enzyme-linked immunosorbent assay for typing strains that uses infection serum ..
  69. pmc Prevalence and risk factors of toxoplasmosis among pregnant women in Fortaleza, Northeastern Brazil
    Susann Sroka
    Institute for Microbiology and Hygiene, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Am J Trop Med Hyg 83:528-33. 2010
    ..Young women in northeastern Brazil living under poor socioeconomic conditions are at highest risk for acquiring infection with T. gondii. Oocyst contamination of water and soil must be addressed in future prevention strategies...
  70. ncbi The history of Toxoplasma gondii--the first 100 years
    Jitender P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Building 1001, Beltsville, Maryland 20705 2350, USA
    J Eukaryot Microbiol 55:467-75. 2008
    In this paper the history of Toxoplasma gondii and toxoplasmosis is reviewed. This protozoan parasite was first discovered in 1908 and named a year later. Its medical importance remained unknown until 1939 when T...
  71. pmc GRA2 and ROP1 recombinant antigens as potential markers for detection of Toxoplasma gondii-specific immunoglobulin G in humans with acute toxoplasmosis
    Lucyna Holec-Gąsior
    Gdansk University of Technology, Department of Microbiology, Poland
    Clin Vaccine Immunol 16:510-4. 2009
    ..A panel of 37 serum samples from patients with acute toxoplasmosis was compared to a panel of 90 serum samples from individuals with past infection...
  72. ncbi Functional characterization of in vivo effector CD4(+) and CD8(+) T cell responses in acute Toxoplasmosis: an interplay of IFN-gamma and cytolytic T cells
    Erik Jongert
    Laboratory for Toxoplasmosis, Pasteur Institute of Brussels, Brussels, Belgium
    Vaccine 28:2556-64. 2010
    ..Both forms of immunization, DNA vaccination and latent infection, completely protected mice against acute Toxoplasmosis. The results obtained in this work suggest that distinct in vivo cytolytic effector mechanisms are at work in ..
  73. ncbi Biology and epidemiology of Toxoplasma gondii in man and animals
    Dolores E Hill
    Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, U S Department of Agriculture Building 1044, BARC East, 70300 Baltimore Avenue, Beltsville, MD 20705 2350, USA
    Anim Health Res Rev 6:41-61. 2005
    ..Clinical and subclinical toxoplasmosis has been reported from wild cervids, ungulates, marsupials, monkeys, and marine mammals...
  74. ncbi Cats and Toxoplasma: implications for public health
    H A Dabritz
    Infant Botulism Treatment and Prevention Program, California Department of Public Health, Richmond, CA 94804, USA
    Zoonoses Public Health 57:34-52. 2010
    ....
  75. pmc Recent developments for diagnosis of toxoplasmosis
    Jack S Remington
    Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, California 94301, USA
    J Clin Microbiol 42:941-5. 2004
  76. ncbi Correlation of duration of latent Toxoplasma gondii infection with personality changes in women
    J Flegr
    Department of Parasitology, Charles University, Prague, Czech
    Biol Psychol 53:57-68. 2000
    Many parasites induce characteristic changes in behavior of their hosts. In humans latent toxoplasmosis is associated with changes in personality profiles...
  77. ncbi Seroepidemiology of Toxoplasma gondii infection in patients with vision and hearing impairments, cancer, HIV, or undergoing hemodialysis in Durango, Mexico
    C Alvarado-Esquivel
    Faculty of Medicine, Juárez University of Durango State, 34000 Durango City, Durango, Mexico
    J Parasitol 96:505-8. 2010
    ..gondii infection than those with normal reflexes (19% vs. 9.4%, respectively: P = 0.04). Results of the present study are the first step in the design of prevention programs to avoid the sequelae of toxoplasmosis.
  78. ncbi Toxoplasma gondii-altered host behaviour: clues as to mechanism of action
    Joanne P Webster
    Department of Infectious Disease Epidemiology, Imperial College, Faculty of Medicine, London, W2 1PG, UK
    Folia Parasitol (Praha) 57:95-104. 2010
    ..Here we consider what the available data to date may reveal about the potential mechanisms involved, the future research that needs to be performed, and the subsequent implications for animal and human health...
  79. pmc Members of a novel protein family containing microneme adhesive repeat domains act as sialic acid-binding lectins during host cell invasion by apicomplexan parasites
    Nikolas Friedrich
    Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Biol Chem 285:2064-76. 2010
    ....
  80. ncbi Decreased level of novelty seeking in blood donors infected with Toxoplasma
    Anna Skallová
    Department of Parasitology, Charles University, Vinicna 7, Prague 128 44, Czech Republic
    Neuro Endocrinol Lett 26:480-6. 2005
    ..The presence of anti-Toxoplasma antibodies (latent toxoplasmosis) is also a risk factor for schizophrenia...
  81. ncbi The role of dopamine in Toxoplasma-induced behavioural alterations in mice: an ethological and ethopharmacological study
    A Skallová
    Department of Parasitology, Faculty of Science, Charles University, Vinicna 7, Prague 128 44, Czech Republic
    Parasitology 133:525-35. 2006
    ..These results suggest an association between Toxoplasma gondii infection and changes in the dopaminergic neuromodulatory system...
  82. pmc Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains
    Jeroen P J Saeij
    Department of Microbiology and Immunology, Fairchild Building D305, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5124, USA
    Infect Immun 73:695-702. 2005
    ..gondii in chronically infected mice. After treatment with dexamethasone, we detected reactivation of toxoplasmosis in mice infected with S23-luc7 and S22-luc2...
  83. ncbi Management of Toxoplasma gondii infection during pregnancy
    Jose G Montoya
    Palo Alto Medical Foundation Toxoplasma Serology Laboratory, Palo Alto, California, USA
    Clin Infect Dis 47:554-66. 2008
    ..for the prevention, diagnosis, and early treatment of the infection in the offspring; this is largely because toxoplasmosis in pregnant women most often goes unrecognized...
  84. ncbi CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells
    J Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Nat Immunol 1:83-7. 2000
    ..These findings support the concept that the early induction of chemokines by invading pathogens is a critical step not only for the recruitment of DC but also for the determination of their subsequent immunologic function...
  85. pmc Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 196:1253-62. 2002
    ..Together, these findings demonstrate a new pathway involving the induction of host LXs for the in vivo regulation of proinflammatory responses during microbial infection...
  86. ncbi Development of a vaccine for toxoplasmosis: current status
    Girish M Bhopale
    Parasitology and Immunodiagnostic Laboratory, Research and Development Division, Hindustan Antibiotics Ltd, Pimpri, Pune 411018, India
    Microbes Infect 5:457-62. 2003
    The need for a vaccine for human toxoplasmosis is briefly discussed...
  87. ncbi Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis?
    Jaroslav Flegr
    Department of Parasitology, Charles University, Vinicna 7, 128 44, Prague, Czech Republic
    Biol Psychol 63:253-68. 2003
    Toxoplasma gondii, a parasitic protozoan, infects about 30-60% of people worldwide. The latent toxoplasmosis, i.e. life-long presence of cysts in the brain and muscular tissues, has no effect on human health...
  88. ncbi Seroepidemiology of Toxoplasma gondii infection in general population in a northern Mexican city
    C Alvarado-Esquivel
    Faculty of Medicine, Juárez University of Durango State, Avenida Universidad S N esquina Fanny Anitua, 34000 Durango, Durango, Mexico
    J Parasitol 97:40-3. 2011
    ..gondii infection. This study provides a basis for the design of successful preventive measures against T. gondii infection...
  89. ncbi Population biology of Toxoplasma gondii and its relevance to human infection: do different strains cause different disease?
    John C Boothroyd
    Department of Microbiology and Immunology, Fairchild Science Building, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Curr Opin Microbiol 5:438-42. 2002
    ..Clear correlations will substantially affect the management of human disease, matching an aggressive infection with an equally aggressive treatment...
  90. ncbi [DNA vaccines and recombinant antigens in prevention of Toxoplasma gondii infections--current status of the studies]
    Elzbieta Hiszczynska-Sawicka
    Katedra Mikrobiologii, Politechnika Gdanska, ul G Narutowicza 11 12, 80 952 Gdansk
    Wiad Parazytol 55:125-39. 2009
    b>Toxoplasmosis caused by an intracellular parasite Toxoplasma gondii is still one of major medical and veterinary problems and there is still need for a vaccine for human toxoplasmosis...
  91. pmc Migratory activation of primary cortical microglia upon infection with Toxoplasma gondii
    Isabel Dellacasa-Lindberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    Infect Immun 79:3046-52. 2011
    Disseminated toxoplasmosis in the central nervous system (CNS) is often accompanied by a lethal outcome...
  92. pmc A Toxoplasma gondii protein with homology to intracellular type Na⁺/H⁺ exchangers is important for osmoregulation and invasion
    Maria E Francia
    Department of Biological Sciences, University of Idaho, Life Sciences South Room 142, Moscow, ID 83844, USA
    Exp Cell Res 317:1382-96. 2011
    ....
  93. pmc Maintained seroprevalence of toxoplasmosis among the residents of Jeju island, Korea
    Sung Jong Hong
    Department of Medical Environmental Biology, College of Medicine, Chung Ang University, Seoul 156 756, Korea
    Korean J Parasitol 49:309-11. 2011
    Seroepidemiological status of toxoplasmosis among the residents of Jeju island was surveyed and evaluated by ELISA with crude extract of Toxoplasma gondii...
  94. pmc Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy
    Bakela Nare
    Department of Human and Animal Infectious Disease Research, Merck Research Laboratories, Merck and Co, Inc, Rahway, New Jersey 07076, USA
    Antimicrob Agents Chemother 46:300-7. 2002
    ..It appears that the cytostatic nature of compound 1 provides an "immunization" phase during chemotherapy which allows the mice to survive the recrudescence and any subsequent challenge with a lethal dose of T. gondii...
  95. ncbi Toxoplasma gondii infection in pregnant women in China
    X J Gao
    Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Zhongshan Medical College, Sun Yat Sen University, Guangzhou 510275, China
    Parasitology 139:139-47. 2012
    b>Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, is one of the most common parasitic infections in humans...
  96. ncbi High diagnostic efficiency of IgM-ELISA with the use of multiple antigen peptides (MAP1) from T. gondii ESA (SAG-1, GRA-1 and GRA-7), in acute toxoplasmosis
    Patrícia Regina Barboza Araújo
    Institute of Tropical Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Rev Inst Med Trop Sao Paulo 52:63-8. 2010
    The main serological marker for the diagnosis of recent toxoplasmosis is the specific IgM antibody, along with IgG antibodies of low avidity...
  97. ncbi Seroprevalence of Toxoplasma gondii in Nazaret town, Ethiopia
    T Negash
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P O Box 1176, Addis Ababa, Ethiopia, Fax 251 11 2755296
    East Afr J Public Health 5:211-4. 2008
    To determine the seroprevalence of toxoplasmosis, assess its zoonotic importance and identify factors associated with seroprevalence.
  98. ncbi Impact of stage differentiation on diagnosis of toxoplasmosis
    Uwe Gross
    Department of Bacteriology, University Hospital of Gottingen, Gottingen, Germany
    Ann Ist Super Sanita 40:65-70. 2004
    ..This short review focuses on the impact of stage differentiation and discusses the potential of stage-specifically expressed antigens that might be useful in a recombinant form in order to improve future serodiagnostical approaches...
  99. ncbi The occurrence of Toxoplasma gondii infection in people and animals from rural environment of Lublin region - estimate of potential role of water as a source of infection
    Jacek Sroka
    Department of Occupational Biohazards, Institute of Agricultural Medicine, Jaczewskiego 2, 20 090 Lublin, Poland
    Ann Agric Environ Med 17:125-32. 2010
    ..in water and occurrence of seropositive reactions in farm inhabitants and/or domestic animals could be found, the above-mentioned data suggest a potential role of potable water in the spread of toxoplasmosis in the rural environment.
  100. pmc A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection
    Melissa B Lodoen
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA
    Cell Microbiol 12:55-66. 2010
    ....
  101. ncbi Toxoplasma gondii tachyzoite-bradyzoite interconversion
    Russell E Lyons
    Commonwealth Scientific and Industrial Research Organisation CSIRO Livestock Industries, Molecular Animal Genetics Centre, University of Queensland, St Lucia, Queensland 4072, Australia
    Trends Parasitol 18:198-201. 2002
    ..gondii undergoes stage conversion between the rapidly dividing tachyzoite that is responsible for acute toxoplasmosis and the slowly replicating, encysted bradyzoite stage...

Research Grants70

  1. MECHANISM-BASED DRUG SELECTION AND DESIGN: NUCLEOTIDE SA
    Buddy Ullman; Fiscal Year: 2003
    ..with pyrimidine synthesis has traditionally provided the most effective tool for management of clinical toxoplasmosis. However, despite the fact that (i) all of these pathogens are purine auxotrophs, (ii) the existing precedent ..
  2. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2012
    ..human infections caused by Leishmania and other pathogens that live inside cells (tuberculosis, malaria, and toxoplasmosis)...
  3. Development of an Inhibitor of Toxoplasma gondii
    Richard D Wood; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Toxoplasma (T.) gondii, the causative agent of toxoplasmosis, is a ubiquitous opportunistic pathogen that infects both immune-competent and immune-compromised individuals worldwide, and is the ..
  4. Role of chemokines in the T cell response to ocular toxoplasmosis
    Christopher A Hunter; Fiscal Year: 2012
    ..one unforeseen complication of such treatment is the inability to control infections, including ocular toxoplasmosis, the leading cause of infectious posterior uveitis worldwide...
  5. Toxoplasma Epigenomics and Gene Expression
    Kami Kim; Fiscal Year: 2013
    ..Understanding how T. gondii regulates gene expression is fundamental for understanding the pathogenesis of toxoplasmosis. Epigenetic factors govern developmental transitions and expression of virulence traits, and are also ..
  6. Translational control and latent Toxoplasma infection
    RONALD C contact WEK; Fiscal Year: 2010
    ..Chronic toxoplasmosis is currently incurable because the parasite is able to develop into cysts that remain latent until ..
  7. How do you build a parasite?
    John Murray; Fiscal Year: 2009
    ..Although the diseases caused by these organisms differ greatly in nature (compare malaria, for example, with toxoplasmosis, or coccidiosis), the pathogenic impact of all apicomplexan parasites is ultimately attributable to ..
  8. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    William J Sullivan; Fiscal Year: 2013
    ..Chronic toxoplasmosis is currently incurable because the parasite is able to develop into cysts that remain latent until ..
  9. Space Renovation for New Research Center for the Neglected Diseases of Poverty
    John Williams; Fiscal Year: 2010
    ..members conducting fundamental NIH-sponsored research on hookworm, schistosomiasis, opisthorchiasis, and toxoplasmosis, as well as epidemiological and policy work...
  10. Control of Immune responses by lipoxins during tuberculosis
    Julio Aliberti; Fiscal Year: 2012
    ....
  11. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher M West; Fiscal Year: 2012
    ..evolutionary conservation of Skp1 glycoregulation in the apicomplexan Toxoplasma gondii, the agent for human toxoplasmosis. The knowledge gained is expected to generate new ideas of how the proteome is regulated in select protists in ..
  12. TARGETING ESSENTIAL ROP KINASES IN TOXOPLASMA
    L David Sibley; Fiscal Year: 2013
    ..Additionally, emerging studies indicate that severe ocular toxoplasmosis can also occur in healthy adults, and that chronic infection is an underlying risk factor for some forms of ..
  13. Antitoxoplasmosis Drug Design and Optimization
    MICHAEL KEVIN RISCOE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Toxoplasma gondii is the causative agent of toxoplasmosis. For most of the estimated 60 million US citizens that have been exposed to the Toxoplasma parasite, most will have very few symptoms because ..
  14. Genetic dissection of parasite metabolism
    Boris Striepen; Fiscal Year: 2013
    ..pathway have been the subject of intensive medicinal chemistry efforts to develop drugs against malaria and toxoplasmosis. However, what the precise function of this pathway for T...
  15. Towards a Vaccine to Prevent Toxoplasmosis
    Rima L McLeod; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The long term goal is to develop a vaccine that prevents toxoplasmosis, including transmission from mother to child and reduction or elimination of organisms during initial acute infection...
  16. Genetic dissection of parasite metabolism
    Boris Striepen; Fiscal Year: 2009
    ..pathway have been the subject of intensive medicinal chemistry efforts to develop drugs against malaria and toxoplasmosis. However, what the precise function of this pathway for T...
  17. Identifying components of Toxoplasma oocysts that confer environmental resistance
    HEATHER MICHELLE FRITZ; Fiscal Year: 2013
    ..in water, soil or vegetables is a significant source of human infections and several waterborne outbreaks of toxoplasmosis have been reported globally...
  18. A novel vacuolar compartment in Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The pathology associated with toxoplasmosis stems from the parasite's lytic cycle initiated by active invasion of host cells...
  19. Calcium Dependent Protein Kinase 1 as a drug target for T. gondii and C. parvum
    ARTHUR CLINTON WHITE; Fiscal Year: 2013
    ..gondii is thought to be critical for the invasion process of T. gondii and thus is a drug target for toxoplasmosis. By inference, the homologous CDPK of C. parvum is likely to be critical for infection by cryptosporidium...
  20. Essential Cell Cycle Mechanisms in Toxoplasma
    Michael W White; Fiscal Year: 2013
    Increased parasite burden is a key factor in the severity of clinical toxoplasmosis and thus, pathogenesis in Toxoplasma gondii infections is caused primarily by the growth of the parasite...
  21. Pathogenic and Protective T Cells in Toxoplasmosis
    George S Yap; Fiscal Year: 2013
    ..Insights from these investigations may become useful for vaccination strategies and the management of inflammatory and infectious diseases. ..
  22. Host cell manipulation by Toxoplasma
    Isabelle Coppens; Fiscal Year: 2013
    ..The currently available treatment for toxoplasmosis shows no efficacy against Toxoplasma long-term chronic infections, resulting in the recrudescence of active ..
  23. MYST opportunities for Toxoplasma drug development
    William J Sullivan Jr; Fiscal Year: 2010
    ..The standard treatment for toxoplasmosis is limiting due to toxic adverse effects, underscoring the need for new drug target discovery...
  24. Training in Tropical and Emerging Global Diseases
    Boris Striepen; Fiscal Year: 2013
    ..for study include malaria, intestinal protozoans, Chagas disease, African sleeping sickness, leishmaniasis, toxoplasmosis, Ichthyophthirius multifiliis, schistosomiasis, lymphatic filariasis, parasitoid insects and culicine, ..
  25. 2010 Biology of Host-Parasite Interactions Gordon Research Conference
    L David Sibley; Fiscal Year: 2010
    ..and molecular aspects of protozoan parasites and how these relate to human diseases including malaria, toxoplasmosis, African and American trypanosomiasis, leishmaniasis, trichomoniasis, giardiasis and entamoebiasis...
  26. Biology of the Apicomplexan Plastid
    Boris Striepen; Fiscal Year: 2013
    ..by applicant): Apicomplexa are responsible for a number of important human diseases including malaria, toxoplasmosis, cryptosporidiosis and cyclosporidiosis...
  27. Host cell influences on the development of toxoplasmic encephalitis
    Anita Koshy; Fiscal Year: 2013
    ..The goal of the research plan is to use the mouse model of toxoplasmosis in combination with site- specific recombination to understand how the cells of the CNS and different strains ..
  28. Molecular mechanisms of pathogenesis in Toxoplasma
    Jon P Boyle; Fiscal Year: 2010
    ..RELEVANCE (See instructions): Toxoplasmosis is a disease that can be very severe in AIDS patients and the developing fetus, and it appears that the ..
  29. Role of intraepithelial T cells in Toxoplasma gondii-induced inflammatory ileitis
    Eric Y Denkers; Fiscal Year: 2010
    ..We expect to gain insight into immunological causes of disease in humans by using Toxoplasma gondii infection as a trigger. The ultimate goal is to develop improved treatments for disease. ..
  30. Targeting Host and Apicomplexan Isoprenoid Pathways
    Silvia N Moreno; Fiscal Year: 2013
    ..provided by applicant): Apicomplexa are important pathogens that include the causative agents of malaria, toxoplasmosis, and cryptosporidiosis...
  31. Optimizing Inhibitors of T. gondii ENR
    Rima L McLeod; Fiscal Year: 2013
    ..This work will create a greatly needed novel class of compound to treat toxoplasmosis.
  32. The Role of CD73 in toxoplasma gondii pathogenesis.
    Deeqa A Mahamed; Fiscal Year: 2012
    ..In this project, we seek to identify how the host ectoenzyme CD73, and its generation of the immunomodulatory molecule adenosine, impacts Toxoplasma gondii infection during both acute and chronic infections. ..
  33. Role of English Fluency in Spanish Neuropsychological Performance
    Paula Suarez; Fiscal Year: 2010
    ..with other Latin American countries, to study the impact of neuro AIDS and associated conditions such as toxoplasmosis in different regions. My hope is that we can disseminate the knowledge obtained here in the U.S. Dr...
  34. Role of CNS Opportunistic Infections in Subsequent Development of HIV Encephaliti
    CARLOS A PARDO-VILLAMIZAR; Fiscal Year: 2012
    ..To determine the extent of glial cell activation and neuronal injury in HIV infected patients with CNS toxoplasmosis or tuberculosis. 2...
  35. The role of lysine methylation in regulating the motility of Toxoplasma gondii
    Ke Hu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Toxoplasmosis is caused by the parasite Toxoplasma gondii. The infection of T...
  36. Innate Immune Receptors for Toxoplasma gondii
    Ricardo Gazzinelli; Fiscal Year: 2010
    ..Studies employing the mouse models of toxoplasmosis indicate that the Myeloid Differentiation Factor 88 (MyD88), an adaptor-signaling molecule for the TLRs, is ..
  37. DESIGNING SELECTIVE INHIBITORS OF CALCIUM-DEPENDENT KINASES IN PARASITES
    L David Sibley; Fiscal Year: 2013
    ..inhibitors will be evaluated for their ability to prevent acute and chronic infection in a rodent model for toxoplasmosis. PUBLIC HEALTH RELEVANCE: Toxoplasma gondii and Cryptosporidium parvum are important food borne pathogens of ..
  38. Initial Events in Human Ocular Toxoplasmosis
    Justine R Smith; Fiscal Year: 2010
    Ocular toxoplasmosis is an inflammatory eye disease caused by infection with the parasite, Toxoplasma gondii. In the US alone, this condition is estimated to affect over 1.25 million individuals...
  39. Infectivity and Transmission of Toxoplasmosis
    L David Sibley; Fiscal Year: 2013
    ..Increasingly, toxoplasmosis has been recognized as a cause of ocular infection in otherwise healthy individuals from South America, where ..
  40. Parasite secreted proteins control host response to Toxoplasma gondii infection
    David J Bzik; Fiscal Year: 2013
    ..This innovative and exploratory R21 project will also illuminate fundamental aspects of parasite vacuole biology, host-parasite interactions, host cell manipulation, and host response during T. gondii infection. ..
  41. Pathogenic and Protective T Cells in Toxoplasmosis
    George Yap; Fiscal Year: 2009
    ..gondii vaccination and infection. We will critically assess the costs and benefits of IL-12 signaling on the immediate and recall CD8 protective response to re-infection. ..
  42. Cytoskeleton scaffold assembly in Toxoplasma gondii
    Marc Jan Gubbels; Fiscal Year: 2012
    ..how to best interfere with division, providing a rational basis for development of new therapeutics to treat toxoplasmosis. PUBLIC HEALTH RELEVANCE: Limited treatment options are available to treat disease caused by Apicomplexa...
  43. Manipulation of host cell acetylome in AIDS opportunistic infection
    William J Sullivan; Fiscal Year: 2013
    ..Thus, an urgent need exists to develop safer and more effective therapies to treat AIDS-toxoplasmosis. Like other intracellular AIDS opportunistic infections, Toxoplasma radically alters its host cell environment ..
  44. Autophagy and ocular toxoplasmosis
    Carlos S Subauste; Fiscal Year: 2013
    ..Ocular toxoplasmosis relapses despite the use of antibiotics and remains an important cause of loss of visual acuity especially in ..
  45. Annual Woods Hole Immunoparasitology (WHIP) Meeting
    Phillip A Scott; Fiscal Year: 2012
    ..g. leishmaniasis, trypanosomiasis, toxoplasmosis, malaria) and helminths (e.g. schisotosomiasis, trichuris, filariasis)...
  46. MICRONEME FUNCTION IN TOXOPLASMA
    VERNON BRUCE CARRUTHERS; Fiscal Year: 2013
    ..the parasite to infect new host cells but the ensuing damage also fuels inflammation and fever, hallmarks of toxoplasmosis and malaria. We recently showed that T...
  47. Inhibition of phosphatase activity as a novel treatment for chronic toxoplasmosis
    Ronald C Wek; Fiscal Year: 2013
    ..Chronic toxoplasmosis is of great clinical importance because the latent infection can reactivate into life-threatening acute ..
  48. Strain-specific host-pathogen interactions in toxoplasmosis
    John C Boothroyd; Fiscal Year: 2013
    ..Both aims will be accomplished through a combination of molecular genetics, imaging and in vivo studies. ..
  49. Toxoplasma gondii: cyst wall
    Louis M Weiss; Fiscal Year: 2013
    ..Understanding this structure is important for the development of new strategies to eliminate latent infection and prevent reactivation toxoplasmosis.
  50. T. Gondii: Pyrimidine Synthesis as a Chemo Target
    David J Bzik; Fiscal Year: 2013
    ..both tachyzoite and bradyzoite stages are urgently needed to treat acute infections as well as to prevent the toxoplasmosis caused by recrudescing parasites...
  51. IFN-gamma production by microglia for prevention of toxoplasmic encephalitis
    Yasuhiro Suzuki; Fiscal Year: 2012
    ..This information will contribute to better understanding of the immunopathogenesis of TE and to improved prevention and management of the disease. ..
  52. Host determinants of Toxoplasma and Listeria invasion
    My Hang Huynh; Fiscal Year: 2010
    ..elucidate the steps involved in microbial invasion to identify potential therapeutic targets for treatment of toxoplasmosis and listeriosis...
  53. Visualizing of Immune Responses to Toxoplasma Gondii
    Ellen A Robey; Fiscal Year: 2013
    ..by applicant): Toxoplasma gondii is an intracellular protozoan parasite that is the causative agent of Toxoplasmosis. Toxoplasma infection in mice provides an excellent experimental model for understanding food borne infections ..
  54. Interhemispheric Research/Training in Infectious Disease
    HERBERT BERNARD TANOWITZ; Fiscal Year: 2013
    ..e., histoplasmosis, sporotrichosis) parasitic diseases (Chagas disease, toxoplasmosis and malaria) and bacterial diseases (legionnaire's disease and tuberculosis) which are endemic to Brazil...
  55. Cellular and molecular mechanisms of host resistance to Toxoplasma gondii
    Felix Yarovinsky; Fiscal Year: 2013
    ..gondii are induced and regulated in the absence of TLR11 (a situation relevant to human toxoplasmosis)...
  56. Functional Studies of Toxoplasma gondii AMA1 and AMA2
    Gary E Ward; Fiscal Year: 2010
    ..provided by the applicant): Apicomplexan parasites such as Toxoplasma gondii, the causative agent of toxoplasmosis, and Plasmodium falciparum, the causative agent of severe human malaria, are obligate intracellular pathogens...
  57. MURINE MODEL OF IMMUNOSUPPRESSION INDUCED CMV RETINITIS
    Patrick Cleveland; Fiscal Year: 1991
    ..are produced by the many opportunistic ocular infections, including cytomegalovirus (CM), Cryptococcosis, Toxoplasmosis, Candida, Mycobacterium, herpes simplex herpes simplex virus, varicella zoster virus, histoplasmosis, and ..
  58. Integrative tools for protozoan parasite research
    Christian J Stoeckert; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Protozoan parasites such as those that cause malaria and toxoplasmosis remain major threats to global health, and a significant biodefense concern...
  59. Ninth International Congress on Toxoplasmosis
    Boris Striepen; Fiscal Year: 2007
    The Ninth International Congress on Toxoplasmosis will be held in June/July[unreadable] 2007 in Chico Hot Springs, Montana. This is an international research conference[unreadable] dedicated to the protozoan pathogen Toxoplasma gondii...
  60. Long-term immunity against Toxoplasmosis
    IMTIAZ AHMED KHAN; Fiscal Year: 2012
    ..PROJECT NARRATIVE Toxoplasma gondii infection is a major problem for HIV-infected subjects. Development of immunotherapeutic agents against this pathogen would reduce the complications in these high-risk individuals. ..
  61. Phosphoproteome of Toxoplasma
    John C Boothroyd; Fiscal Year: 2013
    ..provided by applicant): Apicomplexan parasites cause many diseases in humans, including malaria and toxoplasmosis. They do this by invading, replicating and exiting human cells...
  62. Role of PD-L1 in Ocular Toxoplasmosis
    Ira J Blader; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ocular toxoplasmosis, which is caused by infections with the protozoan parasite Toxoplasma gondii, is the most common form of infectious retinitis...
  63. PURINE BOTTLENECKS FOR THE CHEMOTHERAPY OF TOXOPLASMOSIS
    ELMER PFEFFERKORN; Fiscal Year: 1999
    ..The investigators view the primary goal of this proposal to be the definitive characterization of those steps in toxoplasma purine metabolism that are targets for the chemotherapy of toxoplasmosis.
  64. "Innate intestinal responses in murine toxoplasmosis"
    Fernando Monroy; Fiscal Year: 2005
    ..abstract_text> ..
  65. MECHANISM BASED DRUG SELECTION AND DESIGN FOR T GONDII
    Keith Joiner; Fiscal Year: 1999
    ..progress we have made in these focus areas, facilitating the development of drugs effective against AIDS-toxoplasmosis. Three projects and three cores are proposed...
  66. CRYSTAL STRUCTURE OF TOXOPLASMA GONDII HGPRT
    DAVID BORHANI; Fiscal Year: 1999
    ..is widely recognized that new drugs having novel mechanisms of action are urgently needed for the treatment of toxoplasmosis. Since T...
  67. Mucosal Immunity to Toxoplasma gondii
    L Sibley; Fiscal Year: 2007
    ..dendritic cells (DC) in the gut are likely key mediators of the initial response; however their role in oral toxoplasmosis has not been characterized previously...
  68. The Role of NKG2D/DAP10 in Toxoplasma gondii Infection
    RACHEL MARGARET PRESTI; Fiscal Year: 2010
    ..We have identified the activating immune receptor, NKG2D, as important for the natural, innate immune response to pathogens. Studies in this grant aim to define its role in oral infection with T. gondii. ..
  69. ANTICOCCIDIAL DRUGS AND DRUG RESISTANCE IN TOXPLASMOSIS
    ELMER PFEFFERKORN; Fiscal Year: 1991
    ..Thus new drugs are needed to treat toxoplasmosis in immunosuppressed patients...
  70. SURFACE PROTEINS OF TOXOPLASMA GONDII
    Gary Ward; Fiscal Year: 2002
    ..As many as 4000 children are born each year in the USA with congenital toxoplasmosis, the symptoms of which range from impaired vision to hydrocephalus and death. T...