falciparum malaria

Summary

Summary: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.

Top Publications

  1. ncbi Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
  2. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
  3. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
  4. pmc Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
    Arjen M Dondorp
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 376:1647-57. 2010
  5. ncbi The pathogenic basis of malaria
    Louis H Miller
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 415:673-9. 2002
  6. pmc Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
    Hugh Reyburn
    London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 329:1212. 2004
  7. ncbi The burden of malaria in pregnancy in malaria-endemic areas
    R W Steketee
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 64:28-35. 2001
  8. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
  9. ncbi Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum
    T J Anderson
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, England
    Mol Biol Evol 17:1467-82. 2000
  10. pmc Estimating the global clinical burden of Plasmodium falciparum malaria in 2007
    Simon I Hay
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Med 7:e1000290. 2010

Detail Information

Publications367 found, 100 shown here

  1. ncbi Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
    ....
  2. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
    Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease...
  3. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
    ..Global risk maps will allow better estimation of potential impact of successful control of malaria in pregnancy...
  4. pmc Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
    Arjen M Dondorp
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 376:1647-57. 2010
    ..We compared parenteral treatment with either artesunate or quinine in African children with severe malaria...
  5. ncbi The pathogenic basis of malaria
    Louis H Miller
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 415:673-9. 2002
    ..The inability of many countries to fund expensive campaigns and antimalarial treatment requires these tools to be highly effective and affordable...
  6. pmc Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
    Hugh Reyburn
    London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 329:1212. 2004
    ..To study the diagnosis and outcomes in people admitted to hospital with a diagnosis of severe malaria in areas with differing intensities of malaria transmission...
  7. ncbi The burden of malaria in pregnancy in malaria-endemic areas
    R W Steketee
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 64:28-35. 2001
    ..The failure to apply known effective antimalarial interventions through antenatal programs continues to contribute substantially to infant deaths globally...
  8. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    ..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
  9. ncbi Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum
    T J Anderson
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, England
    Mol Biol Evol 17:1467-82. 2000
    ..These data reveal a range of population structures within a single pathogen species and suggest intimate links between patterns of epidemiology and genetic structure in this organism...
  10. pmc Estimating the global clinical burden of Plasmodium falciparum malaria in 2007
    Simon I Hay
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Med 7:e1000290. 2010
    ..a new cartographic technique and its application for deriving global clinical burden estimates of Plasmodium falciparum malaria for 2007, and to compare these estimates and their likely precision with those derived under existing ..
  11. ncbi A climate-based distribution model of malaria transmission in sub-Saharan Africa
    M H Craig
    National Malaria Research Programme, South African Medical Research Council, PO Box 17120, Congella, Durban 4013, South Africa
    Parasitol Today 15:105-11. 1999
    ..Together with population, morbidity and mortality data, the model provides a fundamental tool for strategic control of malaria...
  12. ncbi Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
    Arjen Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Lancet 366:717-25. 2005
    ..In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain...
  13. ncbi Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
    John C Wootton
    Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 6075, USA
    Nature 418:320-3. 2002
    ..The presence of linkage disequilibrium provides a basis for mapping genes under drug selection in P. falciparum...
  14. pmc Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment
    Verena Ilona Carrara
    Shoklo Malaria Research Unit, Tak, Thailand
    PLoS ONE 4:e4551. 2009
    Artemisinin combination treatments (ACT) are recommended as first line treatment for falciparum malaria throughout the malaria affected world...
  15. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005
    ..Thus, serological tools allow us to detect variations in malaria transmission over time. Such tools will be invaluable for monitoring trends in malaria endemicity and the effectiveness of malaria control programs...
  16. ncbi A molecular marker for chloroquine-resistant falciparum malaria
    A Djimde
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    N Engl J Med 344:257-63. 2001
    Chloroquine-resistant Plasmodium falciparum malaria is a major health problem, particularly in sub-Saharan Africa...
  17. ncbi Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi
    James G Kublin
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 187:1870-5. 2003
    ..chloroquine with sulfadoxine-pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum malaria. To determine whether withdrawal of chloroquine can lead to the reemergence of chloroquine sensitivity, the ..
  18. ncbi Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection
    Kent E Kester
    Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    J Infect Dis 200:337-46. 2009
    ..To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS,S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals)...
  19. pmc The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis
    Freya J I Fowkes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Med 7:e1000218. 2010
    ..However, published evidence of the protective effect of these antibodies is conflicting...
  20. ncbi Variation in malaria transmission intensity in seven sites throughout Uganda
    Paul Edward Okello
    Epidemiological Surveillance Division, Ministry of Health, Kampala, Uganda
    Am J Trop Med Hyg 75:219-25. 2006
    ..However, in the high transmission areas, additional measures will be needed to reduce the malaria burden to acceptable levels...
  21. ncbi Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coast
    Charles M Mbogo
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Am J Trop Med Hyg 68:734-42. 2003
    ..The field-based estimate of entomologic parameters on a district level does not provide a sensitive indicator of transmission intensity in this study...
  22. pmc A world malaria map: Plasmodium falciparum endemicity in 2007
    Simon I Hay
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute University of Oxford Wellcome TrustCollaborative Programme, Nairobi, Kenya
    PLoS Med 6:e1000048. 2009
    ..It is exactly 40 y since the last global map of malaria endemicity was published. This paper describes the generation of a new world map of Plasmodium falciparum malaria endemicity for the year 2007.
  23. ncbi The effect of deforestation on the human-biting rate of Anopheles darlingi, the primary vector of Falciparum malaria in the Peruvian Amazon
    Amy Yomiko Vittor
    School of Medicine, Stanford University, Stanford, California, USA
    Am J Trop Med Hyg 74:3-11. 2006
    ..Our results indicate that A. darlingi displays significantly increased human-biting activity in areas that have undergone deforestation and development associated with road development...
  24. pmc Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 2:e204. 2005
    In falciparum malaria sequestration of erythrocytes containing mature forms of Plasmodium falciparum in the microvasculature of vital organs is central to pathology, but quantitation of this hidden sequestered parasite load in vivo has ..
  25. pmc Marked increase in child survival after four years of intensive malaria control
    Immo Kleinschmidt
    London School of Hygiene and Tropical Medicine, London, United Kingdom Medical Care Development International, Silver Spring, Maryland
    Am J Trop Med Hyg 80:882-8. 2009
    ..34 [95% CI = 0.23-0.49]). Effective malaria control measures can dramatically increase child survival and play a key role in achieving millennium development goals...
  26. ncbi Immune effector mechanisms in malaria
    K Marsh
    KEMRI Centre for Geographic Medicine Research Coast CGMRC, PO Box 230, Kilifi, Kenya
    Parasite Immunol 28:51-60. 2006
    ....
  27. ncbi Intercontinental spread of pyrimethamine-resistant malaria
    Cally Roper
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Science 305:1124. 2004
    ..The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis...
  28. ncbi The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria
    N P Day
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Infect Dis 180:1288-97. 1999
    ..and antiinflammatory cytokines were measured on admission in 287 consecutive Vietnamese adults with severe falciparum malaria. Plasma interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-alpha concentrations and the IL-6: IL-10 ..
  29. ncbi The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    ..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
  30. ncbi Serology: a robust indicator of malaria transmission intensity?
    Patrick Corran
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine LSHTM, Keppel St, London, WC1E 7HT, UK
    Trends Parasitol 23:575-82. 2007
    ..Here we present a suggested methodology, highlight the advantages and shortcomings of serological measurements of malaria transmission and identify areas in which further work is desirable...
  31. ncbi The sick placenta-the role of malaria
    B J Brabin
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Placenta 25:359-78. 2004
    The human placenta is an ideal site for the accumulation of Plasmodium falciparum malaria parasites, and as a consequence serious health problems arise for the mother and her baby...
  32. pmc Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial
    Frank Smithuis
    Medecins Sans Frontieres Holland, Yangon, Myanmar
    Lancet Infect Dis 10:673-81. 2010
    Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout the world, and fixed-dose combinations are preferred by WHO; whether a single gametocytocidal dose of primaquine should be added ..
  33. ncbi Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-analysis
    Lucy C Okell
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    J Infect Dis 200:1509-17. 2009
    ..Quantifying these submicroscopic infections is therefore key to understanding transmission dynamics and successfully reducing parasite transmission...
  34. pmc Dried blood spots as a source of anti-malarial antibodies for epidemiological studies
    Patrick H Corran
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Malar J 7:195. 2008
    ..Although recommendations for the storage and analysis of small molecule analytes in blood spots exist, there are no published systematic studies of the stability of antibodies under different storage conditions...
  35. ncbi Sensitive and inexpensive molecular test for falciparum malaria: detecting Plasmodium falciparum DNA directly from heat-treated blood by loop-mediated isothermal amplification
    Leo L M Poon
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR
    Clin Chem 52:303-6. 2006
    ..The aim of the present work was to develop a simple, inexpensive molecular test for Plasmodium falciparum...
  36. ncbi Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome
    Shamez Ladhani
    Centre for Geographical Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Br J Haematol 119:839-47. 2002
    Little is known about the changes in white blood cells and platelets in children with falciparum malaria in endemic areas...
  37. pmc Rapid testing for malaria in settings where microscopy is available and peripheral clinics where only presumptive treatment is available: a randomised controlled trial in Ghana
    Evelyn K Ansah
    Dangme West District Health Directorate, Dodowa, Ghana
    BMJ 340:c930. 2010
    ....
  38. ncbi High prevalence of asymptomatic Plasmodium vivax and Plasmodium falciparum infections in native Amazonian populations
    Fabiana P Alves
    Department of Parasitology, University of Sao Paulo, Sao Paulo, Brazil
    Am J Trop Med Hyg 66:641-8. 2002
    ..The high prevalence of symptomless malaria may pose new problems for the currently adopted strategy for the control of malaria in the Amazonian region, which is essentially based on the treatment of symptomatic patients...
  39. pmc Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness
    Danielle I Stanisic
    Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Infect Immun 77:1165-74. 2009
    ..However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation...
  40. pmc Rapid assessment of malaria transmission using age-specific sero-conversion rates
    Laveta Stewart
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    PLoS ONE 4:e6083. 2009
    ..This study evaluated SCR generated from samples collected from health facility attendees as a tool for a rapid assessment of malaria transmission intensity...
  41. pmc A weather-driven model of malaria transmission
    Moshe B Hoshen
    Virtual Population Laboratory, Department of Physics, University of Liverpool, Liverpool L69 7ZE, UK
    Malar J 3:32. 2004
    ..Climate is a major driving force behind malaria transmission and climate data are often used to account for the spatial, seasonal and interannual variation in malaria transmission...
  42. pmc International population movements and regional Plasmodium falciparum malaria elimination strategies
    Andrew J Tatem
    Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 107:12222-7. 2010
    ..Here, census-based migration data were analyzed with network analysis tools, Plasmodium falciparum malaria transmission maps, and global population databases to map globally communities of countries linked by ..
  43. pmc Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
    P C Bull
    Kenya Medical Research Institute CRC, Kilifi Unit
    Nat Med 4:358-60. 1998
    ..The apparent selective pressure exerted by established anti-PfEMP1 antibodies on infecting parasites supports the idea that such responses provide variant-specific protection against disease...
  44. ncbi Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children
    Emmanuel Arinaitwe
    Makerere University University of California San Francisco Research Collaboration, University of California, San Francisco 94143, USA
    Clin Infect Dis 49:1629-37. 2009
    ..However, which therapies are optimal is a matter of debate. We aimed to compare the short- and longer-term efficacy of 2 leading therapies in a cohort of young Ugandan children...
  45. pmc Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait
    Thomas N Williams
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi, Kenya
    Nat Genet 37:1253-7. 2005
    ..Individually, each is protective against severe Plasmodium falciparum malaria, but little is known about their malaria-protective effects when inherited in combination...
  46. ncbi A family affair: var genes, PfEMP1 binding, and malaria disease
    Susan M Kraemer
    Seattle Biomedical Research Institute, Seattle, WA 98109 5219, USA
    Curr Opin Microbiol 9:374-80. 2006
    ..Detailed understanding of PfEMP1 expression and receptor binding mechanisms during infection and of the antigenic relatedness of disease variants might lead to new approaches in prevention of malaria disease...
  47. pmc Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial
    Hugh Reyburn
    Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 334:403. 2007
    ..To compare rapid diagnostic tests (RDTs) for malaria with routine microscopy in guiding treatment decisions for febrile patients...
  48. pmc Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial
    Boubacar Coulibaly
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
    PLoS ONE 4:e5318. 2009
    ..We here report on the effects of methylene blue (MB)-based malaria combination therapy on gametocytaemia during a randomised-controlled trial in Burkina Faso...
  49. ncbi Return of chloroquine antimalarial efficacy in Malawi
    Miriam K Laufer
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    N Engl J Med 355:1959-66. 2006
    ..The molecular marker of chloroquine-resistant falciparum malaria subsequently declined in prevalence and was undetectable by 2001, suggesting that chloroquine might once ..
  50. ncbi In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
    Christin Sisowath
    Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Infect Dis 191:1014-7. 2005
    ..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
  51. pmc Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
    Amar bir Singh Sidhu
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
    J Infect Dis 194:528-35. 2006
    ..These results highlight the importance of pfmdr1 copy number in determining P. falciparum susceptibility to multiple agents currently being used to combat malaria caused by multidrug-resistant parasites...
  52. ncbi Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study
    J Whitworth
    Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe
    Lancet 356:1051-6. 2000
    ..An association between HIV-1 and malaria is expected in theory, but has not been convincingly shown in practice. We studied the effects of HIV-1 infection and advancing immunosuppression on falciparum parasitaemia and clinical malaria...
  53. pmc Spatial and temporal distribution of falciparum malaria in China
    Hualiang Lin
    National Institute for Communicable Disease Control and Prevention, China CDC, State Key Laboratory for Infectious Disease Prevention and Control, Beijing, PR China
    Malar J 8:130. 2009
    b>Falciparum malaria is the most deadly among the four main types of human malaria...
  54. ncbi Reaching the Abuja target for intermittent preventive treatment of malaria in pregnancy in African women: a review of progress and operational challenges
    Jenny Hill
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Trop Med Int Health 11:409-18. 2006
    ....
  55. ncbi Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
    Thomas N Williams
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Blood 106:368-71. 2005
    ..Our study supports the conclusion that both heterozygotes and homozygotes enjoy a selective advantage against death from Plasmodium falciparum malaria.
  56. pmc Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia
    Pharath Lim
    Institut Pasteur in Cambodia, Phnom Penh, Cambodia
    Malar J 8:11. 2009
    ..combination of artesunate and mefloquine was introduced as the national first-line treatment for Plasmodium falciparum malaria in Cambodia in 2000...
  57. ncbi Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda
    Heidi Hopkins
    University of California, San Francisco, San Francisco, California, USA
    J Infect Dis 197:510-8. 2008
    ..In Africa, fever is often treated presumptively as malaria, resulting in misdiagnosis and the overuse of antimalarial drugs. Rapid diagnostic tests (RDTs) for malaria may allow improved fever management...
  58. ncbi Towards a comprehensive simulation model of malaria epidemiology and control
    T Smith
    Swiss Tropical Institute, Socinstrasse 57, PO Box, CH 4002 Basel, Switzerland
    Parasitology 135:1507-16. 2008
    Planning of the control of Plasmodium falciparum malaria leads to a need for models of malaria epidemiology that provide realistic quantitative prediction of likely epidemiological outcomes of a wide range of control strategies...
  59. ncbi Intestinal helminth infections are associated with increased incidence of Plasmodium falciparum malaria in Thailand
    M Nacher
    Unité INSERM 511, Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, CHU Pitie Salpetriere, Paris, France
    J Parasitol 88:55-8. 2002
    ..Among 731 villagers, helminth-infected subjects were more likely to develop falciparum malaria during the following year (adjusted risk ratio 2.24, range 1.4-3.6; P = 0.001)...
  60. pmc Combined measurement of soluble and cellular ICAM-1 among children with Plasmodium falciparum malaria in Uganda
    Christine M Cserti-Gazdewich
    Department of Laboratory Medicine and Pathobiology, University Health Network University of Toronto, Canada
    Malar J 9:233. 2010
    ..adhesion molecule-1 (ICAM-1) is a cytoadhesion molecule implicated in the pathogenesis of Plasmodium falciparum malaria. Elevated levels of soluble ICAM-1 (sICAM-1) have previously been reported with increased malaria disease ..
  61. ncbi Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria
    Spencer D Polley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Vaccine 23:718-28. 2004
    ..Results encourage the development of an AMA1 vaccine based on the full-length ectodomain, and indicate that the function of human antibodies to allele-specific and conserved epitopes in AMA1 should be studied further...
  62. pmc Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria
    Michael Walther
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    PLoS Pathog 5:e1000364. 2009
    ..Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections...
  63. pmc Clinical review: Severe malaria
    Andrej Trampuz
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Crit Care 7:315-23. 2003
    ..Intravenous quinine and quinidine are the most widely used drugs in the initial treatment of severe falciparum malaria, whereas artemisinin derivatives are currently recommended for quinine-resistant cases...
  64. ncbi Demographic risk factors for severe and fatal vivax and falciparum malaria among hospital admissions in northeastern Indonesian Papua
    Mazie J Barcus
    US Naval Medical Research Unit 2, Jakarta, Indonesia
    Am J Trop Med Hyg 77:984-91. 2007
    ..748). This study compares admissions per population (based on census data), parasitemia, morbidity, and mortality among children versus adults, pregnant versus non-pregnant women, and urban/suburban versus rural residents...
  65. ncbi A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea
    Blaise Genton
    Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
    J Infect Dis 185:820-7. 2002
    ..The vaccine-induced selection pressure exerted on the parasites and its consequences for morbidity strongly argue for developing vaccines comprising conserved antigens and/or multiple components covering all important allelic types...
  66. pmc White blood cell counts and malaria
    F Ellis McKenzie
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 192:323-30. 2005
    ..For instance, in the present study, use of this conventional approach would have overestimated average asexual parasite densities in the P. falciparum-infected patients in Thailand by nearly one-third...
  67. ncbi Potential effect of climate change on malaria transmission in Africa
    Frank C Tanser
    Malaria Research Lead Programme, Medical Research Council, Overport, Durban, South Africa
    Lancet 362:1792-8. 2003
    ..Climate change is likely to affect transmission of vector-borne diseases such as malaria. We quantitatively estimated current malaria exposure and assessed the potential effect of projected climate scenarios on malaria transmission...
  68. pmc Severe falciparum malaria in Gabonese children: clinical and laboratory features
    Arnaud Dzeing-Ella
    Department of Parasitology, Mycology and Tropical Medicine, Faculty of Medicine, University of Health Sciences USS, Libreville, Gabon
    Malar J 4:1. 2005
    ..This study examined the prognostic indicators of severe falciparum malaria in Gabonese children.
  69. pmc Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria
    Andrew E Fry
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 17:567-76. 2008
    ..5-99.9th centile). This low F(ST) region may be a signal of long-standing balancing selection at the ABO locus, caused by multiple infectious pathogens including P. falciparum...
  70. ncbi Mathematical modeling of the impact of malaria vaccines on the clinical epidemiology and natural history of Plasmodium falciparum malaria: Overview
    Thomas Smith
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 75:1-10. 2006
    ..This paper outlines for a non-mathematical audience the approach we have taken and its underlying rationale...
  71. pmc A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3: implications for malaria rapid diagnostic tests
    Dionicia Gamboa
    Instituto de Medicina Tropical Alexander von Humboldt Universidad Peruana Cayetano Heredia, Lima, Peru
    PLoS ONE 5:e8091. 2010
    ..The selection of the most suitable malaria RDTs is critical to the success of the programmes...
  72. ncbi Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Am J Trop Med Hyg 68:115-9. 2003
    ..0001), number of ANC visits (P = 0.002), and recent febrile symptoms (P = 0.0001). Pigment-containing placental monocytes are associated with anemia and LBW due to malaria, and may have a causative role in their development...
  73. pmc Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies
    Kristina E M Persson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Clin Invest 118:342-51. 2008
    ..falciparum and that a broad inhibitory response against multiple ligands may be required for effective immunity...
  74. ncbi Spatial and temporal variations of malaria epidemic risk in Ethiopia: factors involved and implications
    Tarekegn Abose Abeku
    Department of Public Health, Erasmus MC, University Medical Centre, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Acta Trop 87:331-40. 2003
    ..Epidemic early warning systems should take account of non-uniform effects of these factors by space and time and thus temporal dimensions need to be considered in spatial models of epidemic risks...
  75. pmc Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: a systematic review and pooled analysis
    Ilona Carneiro
    Disease Control and Vector Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 5:e8988. 2010
    There is evidence that the age-pattern of Plasmodium falciparum malaria varies with transmission intensity...
  76. pmc Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A
    Michele D Spring
    United States Military Malaria Vaccine Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 4:e5254. 2009
    ....
  77. ncbi Chloroquine-resistant malaria
    T E Wellems
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 184:770-6. 2001
    ..Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency...
  78. pmc Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
    Severe falciparum malaria (SM) is associated with tissue ischemia related to cytoadherence of parasitized erythrocytes to microvascular endothelium and reduced levels of NO and its precursor, l-arginine...
  79. ncbi Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum
    J Teun Bousema
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Infect Dis 193:1151-9. 2006
    ....
  80. ncbi The public health impact of chloroquine resistance in Africa
    J F Trape
    Laboratoire de Paludologie, Institut de recherche pour le developpement IRD, formerly ORSTOM, Dakar, Senegal
    Am J Trop Med Hyg 64:12-7. 2001
    ..There is an urgent need to change treatment policies in Africa...
  81. pmc Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children
    Daniel Dodoo
    Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Malar J 7:142. 2008
    ..This study was aimed at assessing in a standardized manner the relationship between the antibody responses to four malaria vaccine candidate antigens and protection from clinical malaria, in a cohort of Ghanaian children...
  82. pmc Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes
    Alexander G Maier
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Cell 134:48-61. 2008
    A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells...
  83. ncbi Haemoglobin C protects against clinical Plasmodium falciparum malaria
    D Modiano
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, WHO Collaborating Centre for Malaria Epidemiology and Control, University of Rome La Sapienza, 00185, Rome, Italy
    Nature 414:305-8. 2001
    ....
  84. pmc Anopheles gambiae immune responses to human and rodent Plasmodium parasite species
    Yuemei Dong
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS Pathog 2:e52. 2006
    ..Furthermore, our data indicate that the mosquito is capable of sensing infected blood constituents in the absence of invading ookinetes, thereby inducing anti-Plasmodium immune responses...
  85. ncbi Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study
    James G Kublin
    Department of Community Health, University of Malawi College of Medicine, Blantyre, Malawi
    Lancet 365:233-40. 2005
    ..To assess the effect of Plasmodium falciparum malaria on concentrations of HIV in blood, we did a prospective cohort study in Malawi.
  86. pmc Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria
    Joel Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:3837-46. 2009
    ..properties of lumefantrine in pregnant women with uncomplicated multidrug-resistant Plasmodium falciparum malaria on the northwestern border of Thailand. Burmese and Karen women (n = 103) with P...
  87. ncbi A principal target of human immunity to malaria identified by molecular population genetic and immunological analyses
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT
    Nat Med 6:689-92. 2000
    ..This demonstrated that serum IgG antibodies against each of the two most frequent allelic types of block 2 of the protein were strongly associated with protection from P. falciparum malaria.
  88. ncbi Diversity of the sarco/endoplasmic reticulum Ca(2+)-ATPase orthologue of Plasmodium falciparum (PfATP6)
    Sabina Dahlström
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Infect Genet Evol 8:340-5. 2008
    ..In conclusion our findings show that PfATP6 is a more diverse gene than previously demonstrated. This natural variation may constitute a starting ground for artemisinin-driven progressive selection of resistant parasites...
  89. ncbi Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial
    Antoinette K Tshefu
    Ecole de Santé Publique, Faculte de Medecine, Universite de Kinshasa, Kinshasa, Democratic Republic of the Congo
    Lancet 375:1457-67. 2010
    ..We compared the efficacy and safety of pyronaridine-artesunate with that of artemether-lumefantrine for treatment of uncomplicated P falciparum malaria.
  90. ncbi Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial
    Patrice Piola
    Epicentre, Paris, France
    Lancet Infect Dis 10:762-9. 2010
    ..We aimed to assess whether artemether-lumefantrine was at least as efficacious as oral quinine for the treatment of uncomplicated falciparum malaria during the second and third trimesters of pregnancy in Mbarara, Uganda.
  91. pmc The entomological inoculation rate and Plasmodium falciparum infection in African children
    D L Smith
    Fogarty International Center, National Institutes of Health, Building 16, 16 Center Drive, Bethesda, Maryland 20892, USA
    Nature 438:492-5. 2005
    ..The results have important implications for public health interventions: the success of malaria control will depend heavily on whether efforts are targeted at those who are most at risk of infection...
  92. ncbi Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes
    M Fried
    U S Army Medical Research Unit, Kenya Medical Research Institute, Kisumu
    J Immunol 160:2523-30. 1998
    ..This is the first demonstration that these placental cytokine changes are associated with poor pregnancy outcomes in humans...
  93. ncbi Malaria trends and challenges in the Greater Mekong Subregion
    Charles Delacollette
    WHO Mekong Malaria Programme, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 40:674-91. 2009
    ..efficacy of recommended first-line antimalarials, eg artemisinin-based combination therapies (ACTs) against falciparum malaria on the Cambodia-Thailand border, the prevalence of counterfeit and substandard antimalarial drugs, the lack ..
  94. pmc Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls
    K E Lyke
    Center for Vaccine Development, The University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 72:5630-7. 2004
    ..A total of 248 cases of severe Plasmodium falciparum malaria among children aged 3 months to 14 years residing in Bandiagara, Mali, were matched to cases of ..
  95. pmc Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
    J Alexandra Rowe
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 104:17471-6. 2007
    ..We hypothesized that blood group O may confer resistance to severe falciparum malaria through the mechanism of reduced rosetting...
  96. ncbi Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    Ric N Price
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
    Lancet 364:438-47. 2004
    ..In 1984 mefloquine was introduced as treatment for uncomplicated falciparum malaria, but substantial resistance developed within 6 years...
  97. ncbi Innate immune response to malaria: rapid induction of IFN-gamma from human NK cells by live Plasmodium falciparum-infected erythrocytes
    Katerina Artavanis-Tsakonas
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Immunol 169:2956-63. 2002
    ..contribution of innate immune responses to the early proinflammatory cytokine response to Plasmodium falciparum malaria, we have examined the kinetics and cellular sources of IFN-gamma production in response to human PBMC ..
  98. pmc Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria
    Federica Verra
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, University of Rome La Sapienza, Rome, Italy
    PLoS ONE 2:e978. 2007
    ..The enhanced immune reactivity in both HbC and HbS carriers supports the hypothesis that the protection against malaria of these adaptive genotypes might be at least partially mediated by acquired immunity against malaria...
  99. ncbi Genetic evidence for the aggravation of Plasmodium falciparum malaria by interleukin 4
    Sandrine Cabantous
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 906, Faculte de Medecine, Aix Marseille Universite, IFR88, 27 Blvd Jean Moulin, Marseille, France
    J Infect Dis 200:1530-9. 2009
    ..In previous work, we have shown that interferon gamma and interleukin 12 protect against CM. Here, we investigated whether interleukin 4 (IL-4) aggravates the risk of severe disease...
  100. ncbi Long-term safety and efficacy of the RTS,S/AS02A malaria vaccine in Mozambican children
    Jahit Sacarlal
    Centro de Investigação em Saúde de Manhiça CISM Manhiça, Mozambique
    J Infect Dis 200:329-36. 2009
    We previously reported that the RTS,S/AS02A vaccine had an acceptable safety profile, was immunogenic, and demonstrated efficacy against Plasmodium falciparum malaria disease for 21 months.
  101. pmc Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02
    Meta Roestenberg
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 3:e3960. 2008
    ..Plasmodium falciparum Apical Membrane Antigen 1 (PfAMA1) is a candidate vaccine antigen expressed by merozoites and sporozoites. It plays a key role in red blood cell and hepatocyte invasion that can be blocked by antibodies...

Research Grants72

  1. Falciparum malaria invasion ligand DNA/protein vaccine
    David Narum; Fiscal Year: 2002
    ..S. military has lost more person days to malaria than to bullets (Beadle and Hoffman, 1993). A vaccine against malaria would have enormous domestic and international commercial value. ..
  2. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..Candidate vaccine proteins will be screened, confirmed and selected for clinical trials using pioneering molecular tools and blood samples from pregnant African women and their infants. ..
  3. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..In P. falciparum malaria, IgG1 and IgG3 are associated with lower parasitemia and reduced risk of infection...
  4. Molecular pathogenesis and genetic diversification of childhood falciparum malari
    STEVE MYER TAYLOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Falciparum malaria remains a grave threat to global health despite recent gains in malaria control...
  5. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    ..will combine measurements of iron absorption during and after successful treatment of acute uncomplicated falciparum malaria with characterization of the pharmacokinetics of the appearance of plasma non-transferrin-bound Iron (NTBI) ..
  6. Malaria vaccines modified with TLR agonist adjuvant
    Elizabeth H Nardin; Fiscal Year: 2010
    ..b>falciparum malaria vaccine by fusing flagellin to full-length circumsporozoite (CS) protein or to well-defined, functional T ..
  7. HOST IMMUNITY TO EBV INFECTION IN VITRO AND IN VIVO
    David A Thorley-Lawson; Fiscal Year: 2013
    ..This study will for the first time provide experimental insight into how the interaction of EBV and P. falciparum malaria increases the risk for eBL...
  8. Pilot studies of the molecular epidemiology of drug-resistant malaria in Myanmar
    Christopher V Plowe; Fiscal Year: 2013
    ..Health Organization (WHO) is coordinating an aggressive effort to contain artemisinin resistant Plasmodium falciparum malaria in Southeast Asia before it spreads from its recent site of emergence in Western Cambodia...
  9. The role of the terminal complement pathway in experimental cerebral malaria.
    Theresa N Ramos; Fiscal Year: 2012
    ..Cerebral malaria (CM) is one of the most severe clinical complications of P. falciparum malaria with a fatality rate of 15-30% and 10% of CM survivors have permanent neurological sequelae...
  10. A cell-based HTS for delayed death inhibitors of the malarial parasite plastid
    DAVID FIDOCK; Fiscal Year: 2009
    ..libraries for compounds that inhibit the development of a compartment called the apicoplast in Plasmodium falciparum malaria parasites...
  11. P.falciparum var gene diversity and malaria control
    KAREN PATRICIA DAY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The burden of Plasmodium falciparum malaria is enormous with up to a million deaths per annum and billions of infections that persist for many months in the human population...
  12. T Cell Immunity in Endemic Burkitt Lymphoma
    Ann M Moormann; Fiscal Year: 2012
    ..Epidemiologic studies of eBL indicate a strong association with Plasmodium falciparum malaria and Epstein-Barr virus (EBV) infections early in childhood...
  13. Functional genomic analysis of host determinants of malaria infection
    Elizabeth Egan; Fiscal Year: 2013
    ..PROJECT NARRATIVE: Plasmodium falciparum malaria is a significant cause of morbidity and mortality among children globally, responsible for over 600,000 ..
  14. Neuropathology of severe malaria in Thailand: MRI studies
    Gary M Brittenham; Fiscal Year: 2011
    ..Worldwide, the most important parasitic disease infecting the central nervous system of humans is Plasmodium falciparum malaria. Our project will take advantage of a unique convergence of resources and expertise at Mahidol University in ..
  15. Innate Immune Activation in Malaria
    Douglas T Golenbock; Fiscal Year: 2013
    ..b>falciparum malaria. We hope to identify immunomarkers of disease, whose expression indicates checkpoints that are critical for ..
  16. Ecology of African Highland Malaria
    Guiyun Yan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Since the late 1980s, a series of Plasmodium falciparum malaria epidemics have occurred in the highlands of African countries...
  17. Targeted Vaccine Development for Pediatric Falciparum Malaria
    Jonathan D Kurtis; Fiscal Year: 2011
    ..aim of this proposal is to identify and evaluate novel candidate antigens for a vaccine against pediatric falciparum malaria. Children suffer the greatest morbidity and mortality from malaria- yet this age group has not been targeted ..
  18. Development of an activity based probe family for metallo aminopeptidases
    Doron Greenbaum; Fiscal Year: 2010
    ..Perhaps the greatest impact of this proposal will be to provide a suite of tools and techniques that will be able to study aminopeptidase mediated pathways in a wide range of biological systems. ..
  19. Role of pfcrt in chloroquine resistance in P. falciparum
    DAVID ARMAND FIDOCK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Plasmodium falciparum malaria exerts a devastating impact on public health in inter-tropical regions, causing 250 million cases and nearly one million deaths each year...
  20. Co-infection of mice with MHV68 and rodent Plasmodium species
    Samuel H Speck; Fiscal Year: 2013
    ..In many regions of central Africa, Plasmodium falciparum malaria is the leading cause of death of children under 5 years old [e.g...
  21. Plasmodium Genus and P. falciparum - P. vivax FISH Assays
    Jyotsna Shah; Fiscal Year: 2009
    ..Delayed or missed diagnosis of falciparum malaria increases the risk of complicated or severe disease, which may be fatal vulnerable populations. P...
  22. Fetal Immunity of Malaria
    Christopher L King; Fiscal Year: 2013
    ..In those newborns who demonstrate immune tolerance, we have shown increased susceptibility to falciparum malaria infection up to 3 years of age...
  23. Pathogenesis of Salmonella bacteremia
    Renee M Tsolis; Fiscal Year: 2013
    ..In children with severe Plasmodium falciparum malaria the prevalence of disseminated NTS infections is particularly striking...
  24. Transfusion in Malaria
    Walter H Dzik; Fiscal Year: 2013
    ..Three features relevant to this project have emerged from prior studies of acute Plasmodium falciparum malaria in children...
  25. Vaccines for human Schistosomiasis japonica
    Jonathan D Kurtis; Fiscal Year: 2011
    ..These experiments identified RAMA, a novel vaccine candidate for falciparum malaria. We now propose to use this novel, validated method together with plasma and epidemiologic data already ..
  26. Novel Plasmodial Surface Anion Channel Inhibitors as Antimalarial Drugs
    Michelle M Butler; Fiscal Year: 2013
    ..It is estimated that there are more than 500 million clinical cases of P. falciparum malaria and one million deaths annually, with ninety percent of the deaths occurring in sub-Saharan Africa...
  27. Malaria Vaccine Based on Self-Assembling Polypeptide Nanoparticles (SAPN)
    DAVID ERVIN LANAR; Fiscal Year: 2012
    ..b>falciparum malaria vaccine that is potentially more protective than those currently in clinical trials, shows excellent heat ..
  28. Identifaction of the genetic basis of primaquine resistance in malaria parasites
    ERIKA LEA FLANNERY; Fiscal Year: 2013
    ..This has resulted in a decrease in the prevalence of P. falciparum, yet in many of the countries where falciparum malaria has been eradicated, vivax malaria remains endemic. P...
  29. Structural Analysis of DNA Replication Machinery of P. falciparum
    SCOTT EUGENE LINDNER; Fiscal Year: 2010
    ....
  30. Immuno-epidemiological epitope mapping of a blood stage malaria vaccine antigen
    Christopher V Plowe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): An effective blood stage Plasmodium falciparum malaria vaccine would be of immense global health benefit, particularly for infants and young children who suffer the greatest burden of malaria ..
  31. PfSPZ Challenge with Chemoprophylaxis: Phase 1 Trial to Assess Liver Stage Drug
    STEPHEN LEV HOFFMAN; Fiscal Year: 2013
    ..b>falciparum malaria;2) the main trial phase will assess the degree of protection against homologous parasites induced by ..
  32. Research Activities in Support of Malaria Prevention and Control in Uganda (PMI)
    MOSES ROBERT KAMYA; Fiscal Year: 2013
    ..and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria. 4) We will prospectively assess the coverage of key malaria control interventions (including insecticide ..
  33. Establishment of a high throughput screen for the discovery of malaria transmissi
    Matthias Marti; Fiscal Year: 2010
    ..Asexual development is also linked to the morbidity and mortality of falciparum malaria. However, the emergence of resistance against all currently used drugs (all of which target asexual stages) ..
  34. Target-Based High-Throughput Screens for Plasmodium falciparum Malaria
    Jon Clardy; Fiscal Year: 2010
    ..Here we will develop a new target-based assay to screen structurally diverse small molecule libraries to identify new antimalarial agents to kill the parasite. ..
  35. Evaluation of Small Molecule Inhibitors of Hemoglobin Transport as Antimalarials
    Theodore F Taraschi; Fiscal Year: 2012
    ..of hemoglobin from host erythrocyte cytosol to the digestive vacuole (DV) in intraerythrocytic Plasmodium falciparum malaria parasites...
  36. Effects of Malaria on EBV Persistence in Children
    Rosemary Rochford; Fiscal Year: 2013
    ..there is a consensus that infection with Epstein-Barr virus (EBV) and repeated infections with Plasmodium falciparum malaria in childhood (e.g...
  37. Exploiting Fatty Acid Metabolism To Cure Malaria
    DAVID ARMAND FIDOCK; Fiscal Year: 2013
    ..provided by applicant): The success of artemisinin-based combination therapies in combating Plasmodium falciparum malaria has inspired calls for the eradication of this devastating parasitic disease...
  38. Multiepitope circumsporozoite P.falciparum malaria subunit vaccine displayed on v
    FIDEL P ZAVALA; Fiscal Year: 2012
    ..b>falciparum malaria-specific immunogen that may be useful as an affordable and effective vaccine to prevent malaria...
  39. Host and Microbial Genetic Determinants of Febrile Illness in West Africa
    Christian Happi; Fiscal Year: 2013
    ..Harvard University, and Tulane University studying the devastating diseases Lassa fever (LF) and Plasmodium falciparum malaria. Moreover, we have a demonstrated deep investment in capacity building and training of African scientists...
  40. Within Host Selection of P. falciparum Variants by Artemisinin Combination Therap
    JONATHAN JAMES JULIANO; Fiscal Year: 2013
    ..Most individuals infected with falciparum malaria carry multiple genetically distinct variants ("genotypes", "strains") which continually evolve and compete ..
  41. Genome-wide studies to identify markers of artemisinin-resistant malaria
    SHANNON TAKALA HARRISON; Fiscal Year: 2013
    ..Artemisinin-resistant Plasmodium falciparum malaria has emerged in western Cambodia and its potential spread threatens to reverse recent gains against malaria ..
  42. P. falciparum Pathways and Pathology: RBC Invasion in the Peruvian Malaria Cohort
    OraLee H Branch; Fiscal Year: 2010
    As Plasmodium falciparum malaria evolves and emerges in new geographic regions, there is an urgency to understand factors that lead to clinical pathology and the development of immunity. P...
  43. The interaction of Burkitt???s lymphoma cofactors EBV and Plasmodium
    ERIC M WOHLFORD; Fiscal Year: 2013
    ..lymphoma with two infectious cofactors: early Epstein Barr virus (EBV) infection and frequent Plasmodium falciparum malaria. Recent research suggests that P...
  44. Lyophilization of Plasmodium falciparum sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2007
    ..An effective vaccine against Plasmodium falciparum malaria will fundamentally alter the cycle of poverty and illness and will accelerate economic investment into ..
  45. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
    ..Antifolate-resistant Plasmodium falciparum malaria is increasing in the same Central and East African countries where HIV infection rates are highest, ..
  46. Evaluation of a synthetic anti-GPI vaccine candidate in severe anemia models of m
    A Stewart Campbell; Fiscal Year: 2010
    Plasmodium falciparum malaria afflicts up to 10% of the global population, resulting in over 600 million infections and two to three million deaths annually...
  47. Malaria in Brazil: RBC variants & parasite invasion
    Sara Lustigman; Fiscal Year: 2009
    ..Our studies could also impact development of global vaccines against P. falciparum malaria that target multiple determinants of merozoite invasion.
  48. IMPACT OF TS PROPHYLAXIS ON ANTIFOLATE RESISTANT MALARIA
    James Kublin; Fiscal Year: 2000
    ..Antifolate-resistant P. falciparum malaria is increasing in the same African countries where HIV infection rates are highest, including Malawi...
  49. Preclinical Studies of Natural Product Derivatives as Antimalarial Agents
    Shuren Zhu; Fiscal Year: 2012
    ..b>falciparum malaria. A two-year Phase I research has discovered novel molecules with potent antimalarial activity against both ..
  50. Azithromycin Combination Therapy in Resistant Malaria
    Charles Knirsch; Fiscal Year: 2000
    The emergence of in vivo resistance of Plasmodium falciparum malaria to standard antimalarial drugs is a major and growing threat to public health in Africa, Asia, and Latin America. Chloroquine treatment is now rarely effective...
  51. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2007
    ..The latter is of special concern, since HIV-infected persons on TS prophylaxis who are infected with falciparum malaria may be more likely to fail SP treatment and progress to severe malaria disease and death...
  52. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..Plasmodium falciparum malaria remains a devastating cause of morbidity and mortality in sub-Saharan Africa...
  53. SP resistance markers & falciparum malaria transmission
    Fabian Mendez; Fiscal Year: 2004
    ..Patients with uncomplicated falciparum malaria will receive and standard SP regimen and will be closely followed for 28 days...
  54. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2005
    ..b>falciparum malaria. Recent work from our laboratory indicates that P...
  55. Functional characterization of a conserved phosphatase of Plasmodium falciparum
    Christopher Campbell; Fiscal Year: 2010
    ..Research contributing to a greater understanding of the mechanisms dependant on the use of this protein will aid in reducing infection resulting from these parasites. ..
  56. Severe falciparum malaria: mechanisms of hypoargininemia
    Bert Lopansri; Fiscal Year: 2006
    ..investigate the role of L-arginine as substrate for nitric oxide synthesis in the pathophysiology of severe falciparum malaria. Globally, malaria causes more morbidity and mortality than any other parasitic disease with most deaths ..
  57. AZITHROMYCIN TREATMENT FOR DRUG-RESISTANT MALARIA
    Jonathan Berman; Fiscal Year: 2000
    The emergence of in vivo resistance of Plasmodium falciparum malaria to standard antimalarial drugs is a major and growing threat to public health in Africa, Asia, and Latin America...
  58. The Burden of Malaria Transmission due to Asymptomatic HIV Co-Infection
    V Ann Stewart; Fiscal Year: 2013
    ..antifolate- resistant parasite genotypes and, therefore, contribute directly to the increased burden of falciparum malaria. To this end, we propose to focus complementary clinical and entomological studies using highly sensitive ..
  59. DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2002
    The emergence of in vivo resistance of Plasmodium falciparum malaria to chloroquine and to the combination antifolate drug pyrimethamine-sulfadoxine (PS) is a major threat to public health in Africa...
  60. Cerebral Malaria Associated Neurological Disorders in India
    Jonathan Stiles; Fiscal Year: 2005
    ..ovae) and it has been estimated that it infects 300-500 million people per year. About 1% of all cases of falciparum malaria results in cerebral malaria and thus affects central nervous system at least in 3 million people especially ..
  61. BACTERIAL LIVE VECTOR-BASED VACCINE AGAINST MALARIA
    Myron Levine; Fiscal Year: 2004
    ..and Shigella live vectors, to develop a mucosally administered multivalent vaccine to prevent Plasmodium falciparum malaria. Proving the broad hypothesis requires that we adapt an attenuated Shigella vaccine strain to deliver ..
  62. Clinical trial of chloroquine combinations in Malawi
    CHRISTOPHER PLOWE; Fiscal Year: 2009
    ..This clinical trial follows our observation that chloroquine-sensitive falciparum malaria has reemerged and now predominates following cessation of chloroquine use in Malawi in 1993...
  63. Pre-Clinical Evaluation of Antimalarial Natural Products from Carica papaya L.
    Shuren Zhu; Fiscal Year: 2009
    ..b>falciparum malaria. Radix Pharmaceuticals has isolated and purified two natural products from the leaves of Carica papaya L...
  64. ERYTHROCYTE ADHESION IN FALCIPARUM MALARIA
    IRWIN SHERMAN; Fiscal Year: 2004
    ..e. peptidomimetics, small molecules, antibodies) that could inhibit or reverse sequestration thus allowing for better and safer therapeutic modalities for individuals suffering from falciparum malaria.
  65. Apolipoprotein E 4/4 protects against falciparum malaria
    Hisashi Fujioka; Fiscal Year: 2005
    ..These studies represent a unique approach in the battle against malaria and could provide the basis for the design of an entirely new class of anti-malarial drugs. ..
  66. New Antimalarials from Plant-Pathogenic Fungi
    NP NANAYAKKARA; Fiscal Year: 2005
    ..these antibiotics are effective in combination with conventional antimalarial drugs against drug-resistant falciparum malaria. However, only very few extracts or secondary metabolites of fungi have been systematically evaluated for ..
  67. Cytoadherence and sequestration in malaria transmission stages
    Matthias Marti; Fiscal Year: 2013
    ..b>falciparum malaria. Previous studies have emphasized the major contribution of the knob complex and particularly the major ..
  68. Synthesis and Evaluation of Novel Antimalarial Agents
    Shuren Zhu; Fiscal Year: 2005
    ..For efficacy evaluation, synthesized compounds will be tested in vitro against two P. falciparum malaria parasite clones: W2 (susceptible to mefloquine but resistant to chloroquine, sulfadoxine, pyrimethamine, and ..
  69. Prevalence and fitness of drug resistant minority variant mutations in Plasmodium
    Steven Meshnick; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Drug-resistant P. falciparum malaria is a major public health problem. Molecular markers for most types of drug resistance have been identified and could serve as surveillance tools...
  70. CLINICAL AND MOLECULAR STUDIES OF DRUG-RESISTANT MALARIA
    MATTHEW DORSEY; Fiscal Year: 2005
    ..sulfadoxine/pyrimethamine (SP) + chloroquine (CQ) to SP + amodiquine (AQ) for the treatment of uncomplicated falciparum malaria at each of the seven sentinel sites...
  71. CR1 Polymorphisms and Susceptibility to Severe Malaria
    JOANN MOULDS; Fiscal Year: 2002
    DESCRIPTION (provided by the applicant): Plasmodium falciparum malaria is one of the most important infectious diseases affecting the human population and is a multi-factorial process influenced by both parasite virulence factors and ..
  72. Zinc Metabolism in Plasmodium Falciparum
    Oluwatosin Gisanrin; Fiscal Year: 2005
    ..falciparum zinc transporter by yeast complementation and/or heterologous expression in Xenopus oocytes and 3) to localize the membrane compartment for the zinc transporter. ..