malaria

Summary

Summary: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Top Publications

  1. ncbi Global malaria mortality between 1980 and 2010: a systematic analysis
    Christopher J L Murray
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA
    Lancet 379:413-31. 2012
  2. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
  3. ncbi The changing epidemiology of malaria elimination: new strategies for new challenges
    Chris Cotter
    The Global Health Group, University of California, San Francisco, CA 94105, USA
    Lancet 382:900-11. 2013
  4. ncbi Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study
    Jean Francois Trape
    Research Unit on Emerging Infectious and Tropical Diseases, Institut de Recherche pour le Developpement, Dakar, Senegal
    Lancet Infect Dis 11:925-32. 2011
  5. ncbi Changes in the burden of malaria in sub-Saharan Africa
    Wendy Prudhomme O'Meara
    George Washington University, USA
    Lancet Infect Dis 10:545-55. 2010
  6. pmc Increased proportions of outdoor feeding among residual malaria vector populations following increased use of insecticide-treated nets in rural Tanzania
    Tanya L Russell
    Ifakara Health Institute, Biomedical and Environmental Thematic Group, Ifakara, Tanzania
    Malar J 10:80. 2011
  7. pmc Operational strategies to achieve and maintain malaria elimination
    Bruno Moonen
    Clinton Health Access Initiative, Nairobi, Kenya
    Lancet 376:1592-603. 2010
  8. pmc A research agenda to underpin malaria eradication
    Pedro L Alonso
    Barcelona Centre for International Health Research Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    PLoS Med 8:e1000406. 2011
  9. ncbi Malaria biology and disease pathogenesis: insights for new treatments
    Louis H Miller
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, USA
    Nat Med 19:156-67. 2013
  10. pmc A global map of dominant malaria vectors
    Marianne E Sinka
    Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Parasit Vectors 5:69. 2012

Detail Information

Publications368 found, 100 shown here

  1. ncbi Global malaria mortality between 1980 and 2010: a systematic analysis
    Christopher J L Murray
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA
    Lancet 379:413-31. 2012
    During the past decade, renewed global and national efforts to combat malaria have led to ambitious goals...
  2. ncbi Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?
    Hilary Ranson
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA
    Trends Parasitol 27:91-8. 2011
    The use of pyrethroid insecticides in malaria vector control has increased dramatically in the past decade through the scale up of insecticide treated net distribution programmes and indoor residual spraying campaigns...
  3. ncbi The changing epidemiology of malaria elimination: new strategies for new challenges
    Chris Cotter
    The Global Health Group, University of California, San Francisco, CA 94105, USA
    Lancet 382:900-11. 2013
    b>Malaria-eliminating countries achieved remarkable success in reducing their malaria burdens between 2000 and 2010. As a result, the epidemiology of malaria in these settings has become more complex...
  4. ncbi Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study
    Jean Francois Trape
    Research Unit on Emerging Infectious and Tropical Diseases, Institut de Recherche pour le Developpement, Dakar, Senegal
    Lancet Infect Dis 11:925-32. 2011
    Substantial reductions in malaria have been reported in several African countries after distribution of insecticide-treated bednets and the use of artemisinin-based combination therapies (ACTs)...
  5. ncbi Changes in the burden of malaria in sub-Saharan Africa
    Wendy Prudhomme O'Meara
    George Washington University, USA
    Lancet Infect Dis 10:545-55. 2010
    The burden of malaria in countries in sub-Saharan Africa has declined with scaling up of prevention, diagnosis, and treatment...
  6. pmc Increased proportions of outdoor feeding among residual malaria vector populations following increased use of insecticide-treated nets in rural Tanzania
    Tanya L Russell
    Ifakara Health Institute, Biomedical and Environmental Thematic Group, Ifakara, Tanzania
    Malar J 10:80. 2011
    Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) represent the front-line tools for malaria vector control globally, but are optimally effective where the majority of baseline transmission occurs indoors...
  7. pmc Operational strategies to achieve and maintain malaria elimination
    Bruno Moonen
    Clinton Health Access Initiative, Nairobi, Kenya
    Lancet 376:1592-603. 2010
    Present elimination strategies are based on recommendations derived during the Global Malaria Eradication Program of the 1960s...
  8. pmc A research agenda to underpin malaria eradication
    Pedro L Alonso
    Barcelona Centre for International Health Research Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    PLoS Med 8:e1000406. 2011
    The interruption of malaria transmission worldwide is one of the greatest challenges for international health and development communities...
  9. ncbi Malaria biology and disease pathogenesis: insights for new treatments
    Louis H Miller
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, USA
    Nat Med 19:156-67. 2013
    Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan, claims the lives of nearly a million children each year in Africa alone and is a top public health concern...
  10. pmc A global map of dominant malaria vectors
    Marianne E Sinka
    Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Parasit Vectors 5:69. 2012
    Global maps, in particular those based on vector distributions, have long been used to help visualise the global extent of malaria. Few, however, have been created with the support of a comprehensive and extensive evidence-based approach.
  11. pmc Heterogeneities in the transmission of infectious agents: implications for the design of control programs
    M E Woolhouse
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, United Kingdom
    Proc Natl Acad Sci U S A 94:338-42. 1997
    ....
  12. pmc G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map
    Rosalind E Howes
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Med 9:e1001339. 2012
    Primaquine is a key drug for malaria elimination. In addition to being the only drug active against the dormant relapsing forms of Plasmodium vivax, primaquine is the sole effective treatment of infectious P...
  13. pmc Acquired immunity to malaria
    Denise L Doolan
    Queensland Institute of Medical Research, The Bancroft Centre, Post Office Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Clin Microbiol Rev 22:13-36, Table of Contents. 2009
    Naturally acquired immunity to falciparum malaria protects millions of people routinely exposed to Plasmodium falciparum infection from severe disease and death. There is no clear concept about how this protection works...
  14. ncbi A large focus of naturally acquired Plasmodium knowlesi infections in human beings
    Balbir Singh
    Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Sarawak, Malaysia
    Lancet 363:1017-24. 2004
    About a fifth of malaria cases in 1999 for the Kapit division of Malaysian Borneo had routinely been identified by microscopy as Plasmodium malariae, although these infections appeared atypical and a nested PCR assay failed to identify P ..
  15. ncbi Optimal temperature for malaria transmission is dramatically lower than previously predicted
    Erin A Mordecai
    Ecology, Evolution, and Marine Biology Department, University of California, Santa Barbara, CA 93106, USA
    Ecol Lett 16:22-30. 2013
    The ecology of mosquito vectors and malaria parasites affect the incidence, seasonal transmission and geographical range of malaria...
  16. pmc Shrinking the malaria map: progress and prospects
    Richard G A Feachem
    The Global Health Group, University of California, San Fransisco, San Francisco, CA 94105, USA
    Lancet 376:1566-78. 2010
    In the past 150 years, roughly half of the countries in the world eliminated malaria. Nowadays, there are 99 endemic countries-67 are controlling malaria and 32 are pursuing an elimination strategy...
  17. pmc Species shifts in the Anopheles gambiae complex: do LLINs successfully control Anopheles arabiensis?
    Jovin Kitau
    Kilimanjaro Christian Medical College, Tumaini University, Moshi, Tanzania
    PLoS ONE 7:e31481. 2012
    ..insecticide treated nets (ITNs and LLINs) in parts of E Africa are associated with reductions in local malaria burdens...
  18. ncbi The burden of malaria in pregnancy in malaria-endemic areas
    R W Steketee
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 64:28-35. 2001
    Pregnant women in malarious areas may experience a variety of adverse consequences from malaria infection including maternal anemia, placental accumulation of parasites, low birth weight (LBW) from prematurity and intrauterine growth ..
  19. ncbi Immunity to malaria: more questions than answers
    Jean Langhorne
    Division of Parasitology, National Institute for Medical Research, London NW7 1AA, UK
    Nat Immunol 9:725-32. 2008
    b>Malaria is one of the main health problems facing developing countries today...
  20. pmc The importance of mosquito behavioural adaptations to malaria control in Africa
    Michelle L Gatton
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892 2220, USA
    Evolution 67:1218-30. 2013
    ..with improved drug therapies, indoor residual spraying (IRS), and better health infrastructure, has helped reduce malaria in many African countries for the first time in a generation...
  21. ncbi Effect of the Affordable Medicines Facility--malaria (AMFm) on the availability, price, and market share of quality-assured artemisinin-based combination therapies in seven countries: a before-and-after analysis of outlet survey data
    Sarah Tougher
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 380:1916-26. 2012
    b>Malaria is one of the greatest causes of mortality worldwide. Use of the most effective treatments for malaria remains inadequate for those in need, and there is concern over the emergence of resistance to these treatments...
  22. pmc The effect of mobile phone text-message reminders on Kenyan health workers' adherence to malaria treatment guidelines: a cluster randomised trial
    Dejan Zurovac
    Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya
    Lancet 378:795-803. 2011
    Health workers' malaria case-management practices often differ from national guidelines...
  23. pmc The dominant Anopheles vectors of human malaria in the Asia-Pacific region: occurrence data, distribution maps and bionomic précis
    Marianne E Sinka
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, UK
    Parasit Vectors 4:89. 2011
    ..in a series of three publications examining the global distribution of 41 dominant vector species (DVS) of malaria is presented here...
  24. ncbi The economic and social burden of malaria
    Jeffrey Sachs
    Center for International Development, John F Kennedy School of Government, Harvard University, 79 John F Kennedy St, Cambridge, Massachusetts 02138, USA
    Nature 415:680-5. 2002
    Where malaria prospers most, human societies have prospered least...
  25. pmc The cellular and molecular basis for malaria parasite invasion of the human red blood cell
    Alan F Cowman
    The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, 3052, Australia
    J Cell Biol 198:961-71. 2012
    b>Malaria is a major disease of humans caused by protozoan parasites from the genus Plasmodium. It has a complex life cycle; however, asexual parasite infection within the blood stream is responsible for all disease pathology...
  26. pmc Combining indoor residual spraying and insecticide-treated nets for malaria control in Africa: a review of possible outcomes and an outline of suggestions for the future
    Fredros O Okumu
    Ifakara Health Institute, Biomedical and Environmental Sciences Thematic group, P, O Box 53 Ifakara, Tanzania
    Malar J 10:208. 2011
    Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are currently the preferred methods of malaria vector control...
  27. pmc Increased use of malaria rapid diagnostic tests improves targeting of anti-malarial treatment in rural Tanzania: implications for nationwide rollout of malaria rapid diagnostic tests
    Irene M Masanja
    INESS programme, Ifakara Health Institute, PO Box 78373, Dar es Salaam, Tanzania
    Malar J 11:221. 2012
    The World Health Organization recommends parasitological confirmation of all malaria cases...
  28. ncbi Early biting rhythm in the Afro-tropical vector of malaria, Anopheles arabiensis, and challenges for its control in Ethiopia
    M Yohannes
    Department of Microbiology, Immunology and Parasitology, College of Health Science, Mekelle University, Tigray, Ethiopia
    Med Vet Entomol 26:103-5. 2012
    The biting cycle of the malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) was assessed by hourly light trap collections in three villages in Tigray, northern Ethiopia...
  29. ncbi A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy
    Bridget E Barber
    Infectious Diseases Unit, Department of Medicine, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia
    Clin Infect Dis 56:383-97. 2013
    Plasmodium knowlesi commonly causes severe malaria in Malaysian Borneo, with high case-fatality rates reported. We compared risk, spectrum, and outcome of severe disease from P...
  30. pmc Community acceptability of use of rapid diagnostic tests for malaria by community health workers in Uganda
    David Mukanga
    Department of Epidemiology and Biostatistics, Makerere University School of Public Health, P, O, Box 7072, Kampala, Uganda
    Malar J 9:203. 2010
    ..combination therapy (ACT) at community level using community health workers (CHWs) for treatment of uncomplicated malaria. Use of ACT with reliance on presumptive diagnosis may lead to excessive use, increased costs and rise of drug ..
  31. ncbi Glucose-6-phosphate dehydrogenase deficiency
    M D Cappellini
    Department of Internal Medicine, University of Milan, Policlinico, Mangiagalli, Regina Elena Foundation IRCCS, Via F Sforza 35, Milan, Italy
    Lancet 371:64-74. 2008
    ..The global distribution of this disorder is remarkably similar to that of malaria, lending support to the so-called malaria protection hypothesis...
  32. pmc Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countries
    Kathryn A O'Connell
    Population Services International, Malaria and Child Survival Department, P O Box 43640, Nairobi, Kenya
    Malar J 10:326. 2011
    Artemisinin-based combination therapy (ACT) is the first-line malaria treatment throughout most of the malaria-endemic world...
  33. pmc Evaluation of a national universal coverage campaign of long-lasting insecticidal nets in a rural district in north-west Tanzania
    Philippa A West
    Department of Infectious Disease Epidemiology, London School of Tropical Medicine and Hygiene, Keppel Street, London, UK
    Malar J 11:273. 2012
    Insecticide-treated nets (ITN) are one of the most effective measures for preventing malaria. Mass distribution campaigns are being used to rapidly increase net coverage in at-risk populations...
  34. ncbi Odor-mediated behavior of Afrotropical malaria mosquitoes
    W Takken
    Laboratory of Entomology, Wageningen Agricultural University, The Netherlands
    Annu Rev Entomol 44:131-57. 1999
    ..l. and Anopheles funestus rank among the world's most efficient vectors of human malaria. Their unique bionomics, particularly their anthropophilic, endophagic and endophilic characters, guarantee a ..
  35. pmc Modelling the impact of vector control interventions on Anopheles gambiae population dynamics
    Michael T White
    MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Parasit Vectors 4:153. 2011
    Intensive anti-malaria campaigns targeting the Anopheles population have demonstrated substantial reductions in adult mosquito density...
  36. ncbi CD8+ T effector memory cells protect against liver-stage malaria
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:1347-57. 2011
    Identification of correlates of protection for infectious diseases including malaria is a major challenge and has become one of the main obstacles in developing effective vaccines...
  37. pmc Malaria resurgence: a systematic review and assessment of its causes
    Justin M Cohen
    Clinton Health Access Initiative, Boston, MA, USA
    Malar J 11:122. 2012
    Considerable declines in malaria have accompanied increased funding for control since the year 2000, but historical failures to maintain gains against the disease underscore the fragility of these successes...
  38. pmc Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study
    Stephanie Dellicour
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    PLoS Med 7:e1000221. 2010
    Comprehensive and contemporary estimates of the number of pregnancies at risk of malaria are not currently available, particularly for endemic areas outside of Africa...
  39. pmc Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya
    Philip Bejon
    Kilifi KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 7:e1000304. 2010
    ..This heterogeneity reduces the efficacy of control strategies, but also implies that focusing control strategies on "hotspots" of transmission could be highly effective...
  40. pmc Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    PLoS Med 5:e128. 2008
    ..The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia.
  41. pmc Factors associated with mosquito net use by individuals in households owning nets in Ethiopia
    Patricia M Graves
    The Carter Center, Atlanta, GA, USA
    Malar J 10:354. 2011
    ..It is important to understand individual level net use factors in the context of the home to modify programmes so as to maximize net use...
  42. pmc Anthropogenic habitat disturbance and ecological divergence between incipient species of the malaria mosquito Anopheles gambiae
    Colince Kamdem
    UMR MIVEGEC UM1, UM2, CNRS 5290, IRD 224, Institut de recherche pour le developpement IRD, Montpellier, France
    PLoS ONE 7:e39453. 2012
    ..which is resulting in deforestation and growth of densely populated urban agglomerates, is associated to ecological divergence and cryptic speciation leading to adaptive radiation within the major malaria mosquito Anopheles gambiae.
  43. pmc Trends in malaria cases, hospital admissions and deaths following scale-up of anti-malarial interventions, 2000-2010, Rwanda
    Corine Karema
    World Health Organization, Global Malaria Programme, Geneva, Switzerland
    Malar J 11:236. 2012
    To control malaria, the Rwandan government and its partners distributed insecticide-treated nets (ITN) and made artemisinin-based combination therapy (ACT) widely available from 2005 onwards...
  44. pmc Biologically meaningful coverage indicators for eliminating malaria transmission
    Samson S Kiware
    Biomedical and Environmental Thematic Group, Ifakara Health Institute, PO Box 53, Ifakara, Tanzania
    Biol Lett 8:874-7. 2012
    ..with long-lasting insecticidal nets and indoor residual sprays, by feeding outdoors or upon animals, are primary malaria vectors in many tropical countries...
  45. pmc Influence of climate on malaria transmission depends on daily temperature variation
    Krijn P Paaijmans
    Department of Entomology, Center for Infectious Disease Dynamics, Penn State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 107:15135-9. 2010
    b>Malaria transmission is strongly influenced by environmental temperature, but the biological drivers remain poorly quantified...
  46. pmc Malaria control and elimination in Sri Lanka: documenting progress and success factors in a conflict setting
    Rabindra R Abeyasinghe
    Country Office, World Health Organization, Port Moresby, National Capital District, Papua New Guinea
    PLoS ONE 7:e43162. 2012
    Sri Lanka has a long history of malaria control, and over the past decade has had dramatic declines in cases amid a national conflict...
  47. ncbi Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis
    Kassoum Kayentao
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    JAMA 309:594-604. 2013
    Intermittent preventive therapy with sulfadoxine-pyrimethamine to control malaria during pregnancy is used in 37 countries in sub-Saharan Africa, and 31 of those countries use the standard 2-dose regimen...
  48. pmc Management of imported malaria in Europe
    Helena H Askling
    Department of Medicine Solna Unit for Infectious Diseases, Karolinska Institutet, Stockholm, Sweden
    Malar J 11:328. 2012
    ..Diseases, Study Group on Clinical Parasitology, summarizes main issues regarding the management of imported malaria cases. Malaria is a rare diagnosis in Europe, but it is a medical emergency...
  49. pmc Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea
    Blaise Genton
    Swiss Tropical Institute, Basel, Switzerland
    PLoS Med 5:e127. 2008
    Severe malaria (SM) is classically associated with Plasmodium falciparum infection. Little information is available on the contribution of P. vivax to severe disease. There are some epidemiological indications that P...
  50. pmc Serological markers suggest heterogeneity of effectiveness of malaria control interventions on Bioko Island, equatorial Guinea
    Jackie Cook
    Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e25137. 2011
    In order to control and eliminate malaria, areas of on-going transmission need to be identified and targeted for malaria control interventions...
  51. pmc Changing patterns of malaria epidemiology between 2002 and 2010 in Western Kenya: the fall and rise of malaria
    Guofa Zhou
    Program in Public Health, College of Health Sciences, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e20318. 2011
    The impact of insecticide treated nets (ITNs) on reducing malaria incidence is shown mainly through data collection from health facilities...
  52. ncbi The state of the art in anti-malarial drug discovery and development
    Jeremy N Burrows
    Medicines for Malaria Venture, ICC, Geneva, Switzerland
    Curr Top Med Chem 11:1226-54. 2011
    b>Malaria is one of the most prevalent and devastating infectious diseases of our time...
  53. pmc Increasing malaria hospital admissions in Uganda between 1999 and 2009
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya
    BMC Med 9:37. 2011
    Some areas of Africa are witnessing a malaria transition, in part due to escalated international donor support and intervention coverage...
  54. pmc Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey data
    Anna Maria van Eijk
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet Infect Dis 11:190-207. 2011
    ..nets and intermittent preventive treatment with sulfadoxine-pyrimethamine are recommended for the control of malaria during pregnancy in endemic areas in Africa, but there has been no analysis of coverage data at a subnational ..
  55. pmc How malaria has affected the human genome and what human genetics can teach us about malaria
    Dominic P Kwiatkowski
    Wellcome Trust Centre for Human Genetics and University Department of Paediatrics, Oxford, United Kingdom
    Am J Hum Genet 77:171-92. 2005
    b>Malaria is a major killer of children worldwide and the strongest known force for evolutionary selection in the recent history of the human genome...
  56. pmc Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countries
    Megan Littrell
    Population Services International, Malaria and Child Survival Department, PO Box 43640, Nairobi, Kenya, Africa
    Malar J 10:327. 2011
    Access to artemisinin-based combination therapy (ACT) remains limited in high malaria-burden countries, and there are concerns that the poorest people are particularly disadvantaged...
  57. pmc Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization
    Aubrey J Cunnington
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Nat Med 18:120-7. 2012
    ..typhimurium by hemolysis. Thus, a mechanism of tolerance to one infection, malaria, impairs resistance to another, NTS...
  58. pmc Genome-wide and fine-resolution association analysis of malaria in West Africa
    Muminatou Jallow
    MRC Laboratories, Fajara, Banjul, Gambia
    Nat Genet 41:657-65. 2009
    We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children...
  59. pmc Can universal insecticide-treated net campaigns achieve equity in coverage and use? the case of northern Nigeria
    Yazoume Ye
    ICF International, 11785 Beltsville Drive, Suite 300, Calverton, MD 20705, USA
    Malar J 11:32. 2012
    Insecticide-treated nets (ITNs) are effective tools for malaria prevention and can significantly reduce severe disease and mortality due to malaria, especially among children under five in endemic areas...
  60. pmc Successful malaria elimination strategies require interventions that target changing vector behaviours
    Tanya L Russell
    James Cook University, Queensland Tropical Health Alliance, Cairns, Queensland, Australia
    Malar J 12:56. 2013
    The ultimate long-term goal of malaria eradication was recently placed back onto the global health agenda...
  61. ncbi Malaria rapid diagnostic tests in endemic settings
    J Maltha
    Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    Clin Microbiol Infect 19:399-407. 2013
    b>Malaria rapid diagnostic tests (RDTs) are instrument-free tests that provide results within 20 min and can be used by community health workers...
  62. pmc Warmer temperatures reduce the vectorial capacity of malaria mosquitoes
    Krijn P Paaijmans
    Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA
    Biol Lett 8:465-8. 2012
    ..Here, using a rodent malaria, we show that vector competence (the maximum proportion of infectious mosquitoes, which implicitly includes ..
  63. pmc Surveillance for malaria elimination in Swaziland: a national cross-sectional study using pooled PCR and serology
    Michelle S Hsiang
    Global Health Group, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e29550. 2012
    To guide malaria elimination efforts in Swaziland and other countries, accurate assessments of transmission are critical...
  64. pmc Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites
    Noah S Butler
    Department of Microbiology, University of Iowa, 3 512 Bowen Science Building, Iowa City, IA 52242, USA
    Cell Host Microbe 9:451-62. 2011
    ..the potential utility of late liver stage-arresting GAP as broadly protective next-generation live-attenuated malaria vaccines and support their potential as a powerful model for identifying antigens to generate cross-stage ..
  65. pmc Community case management of malaria using ACT and RDT in two districts in Zambia: achieving high adherence to test results using community health workers
    Pascalina Chanda
    Department of Public Health and Research, Ministry of Health Headquarters, Lusaka, Zambia
    Malar J 10:158. 2011
    Access to prompt and effective treatment is a cornerstone of the current malaria control strategy. Delays in starting appropriate treatment is a major contributor to malaria mortality...
  66. ncbi Indoor residual spraying for preventing malaria
    Bianca Pluess
    Public Health and Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland, 4002
    Cochrane Database Syst Rev 4:CD006657. 2010
    BACKGROUND: Primary malaria prevention on a large scale depends on two vector control interventions: indoor residual spraying (IRS) and insecticide-treated mosquito nets (ITNs)...
  67. ncbi High efficiency transfection of Plasmodium berghei facilitates novel selection procedures
    Chris J Janse
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    Mol Biochem Parasitol 145:60-70. 2006
    The use of transfection in the study of the biology of malaria parasites has been limited due to poor transfection efficiencies (frequency of 10(-6) to 10(-9)) and a paucity of selection markers...
  68. pmc Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications
    J Alexandra Rowe
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, UK
    Expert Rev Mol Med 11:e16. 2009
    Severe malaria has a high mortality rate (15-20%) despite treatment with effective antimalarial drugs. Adjunctive therapies for severe malaria that target the underlying disease process are therefore urgently required...
  69. pmc The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors
    Jean Philippe David
    Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, United Kingdom
    Proc Natl Acad Sci U S A 102:4080-4. 2005
    ..The applications of this detox chip and its potential contribution to malaria vector insecticide resistance management programs are discussed.
  70. pmc Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia
    Timothy William
    Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysian Borneo
    Emerg Infect Dis 17:1248-55. 2011
    The simian parasite Plasmodium knowlesi causes severe human malaria; the optimal treatment remains unknown...
  71. pmc Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
    Sophie H Adjalley
    Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:E1214-23. 2011
    Clinical studies and mathematical models predict that, to achieve malaria elimination, combination therapies will need to incorporate drugs that block the transmission of Plasmodium falciparum sexual stage parasites to mosquito vectors...
  72. pmc Multiple insecticide resistance: an impediment to insecticide-based malaria vector control program
    Delenasaw Yewhalaw
    Department of Biology, Jimma University, Jimma, Ethiopia
    PLoS ONE 6:e16066. 2011
    ..Spraying (IRS), insecticide-treated nets (ITNs) and long-lasting insecticidal nets (LLINs) are key components in malaria prevention and control strategy...
  73. pmc Spiroindolones, a potent compound class for the treatment of malaria
    Matthias Rottmann
    Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH 4002 Basel, Switzerland
    Science 329:1175-80. 2010
    ..The optimized spiroindolone NITD609 shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model.
  74. pmc Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
    Improving the accuracy of malaria diagnosis with rapid antigen-detection diagnostic tests (RDTs) has been proposed as an approach for reducing overtreatment of malaria in the current era of widespread implementation of artemisinin-based ..
  75. ncbi From malaria control to eradication: The WHO perspective
    Kamini Mendis
    Global Malaria Programme, World Health Organization, Geneva, Switzerland
    Trop Med Int Health 14:802-9. 2009
    Efforts to control malaria have been boosted in the past few years with increased international funding and greater political commitment...
  76. pmc Larval source management for malaria control in Africa: myths and reality
    Ulrike Fillinger
    Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Malar J 10:353. 2011
    As malaria declines in many African countries there is a growing realization that new interventions need to be added to the front-line vector control tools of long-lasting impregnated nets (LLINs) and indoor residual spraying (IRS) that ..
  77. pmc Integrated malaria vector control with microbial larvicides and insecticide-treated nets in western Kenya: a controlled trial
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 87:655-65. 2009
    To assess the contributions of both microbial larvicides and insecticide-treated nets (ITNs) in terms of reducing malaria incidence in an integrated vector management programme in an area moderately endemic for malaria in the western ..
  78. pmc Odorant reception in the malaria mosquito Anopheles gambiae
    Allison F Carey
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 464:66-71. 2010
    The mosquito Anopheles gambiae is the major vector of malaria in sub-Saharan Africa. It locates its human hosts primarily through olfaction, but little is known about the molecular basis of this process...
  79. pmc Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trial
    Kojo Yeboah-Antwi
    Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000340. 2010
    Pneumonia and malaria, two of the leading causes of morbidity and mortality among children under five in Zambia, often have overlapping clinical manifestations...
  80. pmc Malaria case-management following change of policy to universal parasitological diagnosis and targeted artemisinin-based combination therapy in Kenya
    Andrew Nyandigisi
    Division of Malaria Control, Ministry of Public Health and Sanitation, Nairobi, Kenya
    PLoS ONE 6:e24781. 2011
    The change of malaria case-management policy in Kenya to recommend universal parasitological diagnosis and targeted treatment with artemether-lumefantrine (AL) is supported with activities aiming by 2013 at universal coverage and ..
  81. pmc Multimodal pyrethroid resistance in malaria vectors, Anopheles gambiae s.s., Anopheles arabiensis, and Anopheles funestus s.s. in western Kenya
    Hitoshi Kawada
    Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    PLoS ONE 6:e22574. 2011
    Anopheles gambiae s.s., Anopheles arabiensis, and Anopheles funestus s.s. are the most important species for malaria transmission...
  82. ncbi Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial
    Sunil Sazawal
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Lancet 367:133-43. 2006
    ..However, there is concern that universal supplementation of children with iron and folic acid in areas of high malaria transmission might be harmful.
  83. pmc Some lessons for the future from the Global Malaria Eradication Programme (1955-1969)
    José A Nájera
    PLoS Med 8:e1000412. 2011
    Encouraged by the early success of using dichloro-diphenyl-trichloroethane (DDT) against malaria, the World Health Organization (WHO) embarked on the Global Malaria Eradication Program (GMEP) in 1955...
  84. pmc A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania
    Seif A Shekalaghe
    Kilimanjaro Christian Medical College Kilimanjaro Clinical Research Institute, Moshi, Tanzania
    Malar J 10:247. 2011
    Effective mass drug administration (MDA) with anti-malarial drugs can clear the human infectious reservoir for malaria and thereby interrupt malaria transmission...
  85. pmc How much does malaria vector control quality matter: the epidemiological impact of holed nets and inadequate indoor residual spraying
    Andrea M Rehman
    MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e19205. 2011
    Insecticide treated nets (ITN) and indoor residual spraying (IRS) are the two pillars of malaria vector control in Africa, but both interventions are beset by quality and coverage concerns...
  86. pmc Lethal and pre-lethal effects of a fungal biopesticide contribute to substantial and rapid control of malaria vectors
    Simon Blanford
    Center for Infectious Disease Dynamics, Mueller Laboratory, Department of Biology, Penn State University, University Park, Pennsylvania, United States of America
    PLoS ONE 6:e23591. 2011
    ..resistance is creating an urgent need for new active ingredients to control the adult mosquitoes that vector malaria. Biopesticides based on the spores of entomopathogenic fungi have shown considerable promise by causing very ..
  87. pmc Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural Tanzania
    Oliver J Sabot
    Malaria Control Team, Clinton Foundation HIV AIDS Initiative, Boston, Massachusetts, USA
    PLoS ONE 4:e6857. 2009
    ..To overcome this challenge, a global ACT subsidy has been proposed. We tested this proposal through a pilot program in rural Tanzania...
  88. pmc A sub-microscopic gametocyte reservoir can sustain malaria transmission
    Stephan Karl
    School of Physics, The University of Western Australia, Crawley, Western Australia, Australia
    PLoS ONE 6:e20805. 2011
    ..These techniques indicate a significant number of people carry gametocyte densities that fall below the conventional threshold of detection achieved by standard light microscopy (LM)...
  89. pmc Low quality of routine microscopy for malaria at different levels of the health system in Dar es Salaam
    Judith Kahama-Maro
    City Medical Office of Health, Dar es Salaam City Council, P O Box 63320, Dar es Salaam, United Republic of Tanzania
    Malar J 10:332. 2011
    Laboratory capacity to confirm malaria cases in Tanzania is low and presumptive treatment of malaria is being practiced widely. In malaria endemic areas WHO now recommends systematic laboratory testing when suspecting malaria...
  90. ncbi Changes in Anopheles funestus biting behavior following universal coverage of long-lasting insecticidal nets in Benin
    Nicolas Moiroux
    MIVEGEC IRD 224 CNRS 5290 UM1 UM2, Institut de Recherche pour le Developpement, Montpellier, France
    J Infect Dis 206:1622-9. 2012
    Behavioral modification of malaria vectors in response to vector control methods is of great concern...
  91. pmc A malaria transmission-directed model of mosquito life cycle and ecology
    Philip A Eckhoff
    Intellectual Ventures Laboratory, 1600 132nd Ave NE, Bellevue, WA 98004, USA
    Malar J 10:303. 2011
    b>Malaria is a major public health issue in much of the world, and the mosquito vectors which drive transmission are key targets for interventions...
  92. pmc Reduction of anti-malarial consumption after rapid diagnostic tests implementation in Dar es Salaam: a before-after and cluster randomized controlled study
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland
    Malar J 10:107. 2011
    Presumptive treatment of all febrile patients with anti-malarials leads to massive over-treatment. The aim was to assess the effect of implementing malaria rapid diagnostic tests (mRDTs) on prescription of anti-malarials in urban Tanzania.
  93. pmc Scaling up malaria control in Zambia: progress and impact 2005-2008
    Elizabeth Chizema-Kawesha
    National Malaria Control Center, Ministry of Health, Ndeke House, Lusaka, Zambia
    Am J Trop Med Hyg 83:480-8. 2010
    ..administrative, health facility, and special study data were used to assess progress and impact in national malaria control between 2000 and 2008...
  94. pmc Major reduction in anti-malarial drug consumption in Senegal after nation-wide introduction of malaria rapid diagnostic tests
    Sylla Thiam
    Programme National de Lutte contre le Paludisme, Ministere de la Sante, Dakar Fann, Senegal
    PLoS ONE 6:e18419. 2011
    While WHO recently recommended universal parasitological confirmation of suspected malaria prior to treatment, debate has continued as to whether wide-scale use of rapid diagnostic tests (RDTs) can achieve this goal...
  95. pmc Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999-2008
    Maru W Aregawi
    World Health Organization, Global Malaria Programme, 20 Avenue Appia 1211 Geneva 27, Switzerland
    Malar J 10:46. 2011
    In Zanzibar, the Ministry of Health and partners accelerated malaria control from September 2003 onwards...
  96. ncbi A global index representing the stability of malaria transmission
    Anthony Kiszewski
    Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Trop Med Hyg 70:486-98. 2004
    To relate stability of malaria transmission to biologic characteristics of vector mosquitoes throughout the world, we derived an index representing the contribution of regionally dominant vector mosquitoes to the force of transmission...
  97. ncbi Individual, household and environmental risk factors for malaria infection in Amhara, Oromia and SNNP regions of Ethiopia
    Patricia M Graves
    The Carter Center, 1 Copenhill, Atlanta, GA 30307, USA
    Trans R Soc Trop Med Hyg 103:1211-20. 2009
    We assessed malaria infection in relation to age, altitude, rainfall, socio-economic factors and coverage of control measures in a representative sample of 11437 people in Amhara, Oromia and SNNP regions of Ethiopia in December 2006-..
  98. pmc Reported reasons for not using a mosquito net when one is available: a review of the published literature
    Justin Pulford
    Papua New Guinea Institute of Medical Research PNGIMR, PO Box 60, Goroka, EHP 441, Papua New Guinea
    Malar J 10:83. 2011
    A review of the barriers to mosquito net use in malaria-endemic countries has yet to be presented in the published literature despite considerable research interest in this area...
  99. pmc Malaria indicator survey 2007, Ethiopia: coverage and use of major malaria prevention and control interventions
    Daddi Jima
    Diseases Prevention and Control Department, Federal Ministry of Health, Addis Ababa, Ethiopia
    Malar J 9:58. 2010
    ..Similar to other sub-Saharan African countries scaling-up malaria interventions, the Government of Ethiopia set an ambitious national goal in 2005 to (i) provide 100% ITN coverage ..
  100. ncbi Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic test
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Clin Infect Dis 51:506-11. 2010
    The availability of a rapid diagnostic test for malaria (RDTm) allows accurate diagnosis at all levels of health facilities...
  101. ncbi Apical membrane antigen 1: a malaria vaccine candidate in review
    Edmond J Remarque
    Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    Trends Parasitol 24:74-84. 2008
    ..The current understanding of AMA1 will be presented, particularly in relation to the vaccine potential of AMA1 and the approaches being taken towards clinical development...

Research Grants80

  1. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..for primary, acute liver failure and viral, alcoholic and autoimmune hepatitis and even the hepatic stage of malaria, especially if a human immune system were reconstituted in addition to the liver...
  2. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malaria affects almost one-half of the world's population and causes more than one million deaths annually...
  3. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..The protection against malaria conferred by SCD and THL mutations increases the numbers of carriers...
  4. Genomics of Antiviral Responses of Anopheles gambiae Against O'nyong-nyong Virus
    Young S Hong; Fiscal Year: 2010
    ..An. gambiae is a major vector for human malaria Plasmodium falciparum in Africa, but it is also a natural vector for O'nyong-nyong virus (ONNV) transmission...
  5. Latin American Center for Malaria Research and Control
    SOCRATES HERRERA VALENCIA; Fiscal Year: 2013
    ..The overall goal of this proposal is the establishment the "Centro Latino Americano de investigacion en Malaria - CLAIM" as a non-Amazonian malaria research center that would generate knowledge and provide technical and ..
  6. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..pediatric severe malarial anemia Severe malarial anemia (SMA) is the most common clinical manifestation of severe malaria in infants and young children living in holoendemic Plasmodium falciparum transmission areas...
  7. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    Cerebral malaria (CM) is a major complication of infection by Plasmodium falciparum. It affects mainly children under 5 years old in sub-Saharan Africa and shows a high mortality rate even when anti- malarial treatment is administered...
  8. Novel genomic effects of Y-linked polymorphisms
    Daniel L Hartl; Fiscal Year: 2012
    ..a key biological factor in limiting the ecological range of many insects including the mosquitoes that transmit malaria. We will also develop theoretical models for the population dynamics of polymorphic Y chromosomes associated with ..
  9. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..This technology, if successful, may also apply to other parasitic protozoa infecting humans, such as malaria, Chagas'disease (American Trypanosomiasis), and Sleeping Sickness (African Trypanosomiasis)...
  10. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ..g., HH, SCD, Thalassemia and malaria. PUBLIC HEALTH RELEVANCE: Basic studies of iron homeostasis, gene and mRNA regulation, and host/pathogen diiron ..
  11. Knockdown of Gene Expression in Immune Cells in Humanized Mice
    Judy Lieberman; Fiscal Year: 2010
    ..to design effective vaccines for many of the world's serious chronic infectious diseases, including HIV, malaria and hepatitis C, have not been successful;vaccines that look promising in other species often fail in human ..
  12. Analysis of the functions of axon guidance genes during vector mosquito developme
    MOLLY DUMAN SCHEEL; Fiscal Year: 2012
    ..These studies will include the yellow and dengue fever virus vector Aedes aegypti, as well as the malaria vector Anopheles gambiae...
  13. Double Humanization of Liver and Blood in Mice
    ELIZABETH MARIE WILSON; Fiscal Year: 2012
    ..The applications include studies of human infectious diseases (hepatitis B and B, malaria etc.), drug metabolism and pharmacokinetics, drug-drug interactions, toxicology and gene therapy among others...
  14. Cerebral Malaria: Mechanisms of disease and neurological salvage
    Mahalia S Desruisseaux; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Greater than 20% of individuals with cerebral malaria (CM) suffer from persistent neurological and cognitive deficits long after successful anti-parasitic treatment...
  15. Pathogenesis of cognitive/neurologic deficits in central nervous system malaria
    Chandy C John; Fiscal Year: 2012
    b>Malaria is a leading cause of morbidity and mortality in children in sub-Saharan Africa, causing >1 million deaths annually. Our studies at Mulago Hospital, Kampala, Uganda document that 21...
  16. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ..Although DDT was banned in the US, it is still used in some countries for malaria control...
  17. The Role of Glycolipids and CD1 in the Immunology of Leishmania Infection
    Laurence U Buxbaum; Fiscal Year: 2012
    ..Leishmaniasis is the number two killer worldwide after malaria for death caused by parasites...
  18. Planning Grant for the Efficacy of Auranofin for the Treatment of Amebiasis
    Sharon L Reed; Fiscal Year: 2012
    ..by applicant): Amebiasis is the third leading cause of death from parasitic infection worldwide, following malaria and schistosomiasis...
  19. Molecular pathogenesis and genetic diversification of childhood falciparum malari
    STEVE MYER TAYLOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Falciparum malaria remains a grave threat to global health despite recent gains in malaria control...
  20. A Systems Biology Approach to the Model Apicomplexan Toxoplasma gondii
    William J Sullivan Jr; Fiscal Year: 2010
    ..Plasmodium species, the agents of malaria, infect over 267 million people per year and cause nearly 1 million deaths per year...
  21. Genome-wide Identification of Immediate Early Genes in Insects
    Anandasankar Ray; Fiscal Year: 2012
    ..neuron activity in three species of insects including Drosophila melanogaster, Drosophila pseudoobscura and the malaria vector Anopheles gambiae...
  22. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..and blood smear for malaria. The primary outcomes will be the incidence of diarrhea and respiratory tract infections...
  23. Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunity
    MICHAEL ALLEN RIEHLE; Fiscal Year: 2012
    ..Since malaria parasites must develop for up to two weeks in the mosquito there is opportunity to disrupt this development by ..
  24. Genetic Analysis of Mosquito Metamorphosis
    James T Nishiura; Fiscal Year: 2012
    Yearly, millions of people die, or are seriously debilitated, from malaria, dengue fever, yellow fever and several forms of viral encephalitis. Hematophageous mosquitoes transmit the causative agents of these diseases [1, 2]...
  25. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    ..combine measurements of iron absorption during and after successful treatment of acute uncomplicated falciparum malaria with characterization of the pharmacokinetics of the appearance of plasma non-transferrin-bound Iron (NTBI) and ..
  26. Role of innate immune responses in the activity of an Alphavirus based adjuvant.
    Robert E Johnston; Fiscal Year: 2013
    ..an increasing need for new adjuvants to potentiate candidate vaccines against other important pathogens such as Malaria, HIV and TB...
  27. NICHD INTERNATIONAL & DOMESTIC PEDIATRIC &MATERNAL HIV STUDIES COORDINATING CTR
    CAROL NESEL; Fiscal Year: 2013
    ..and children, research gaps related to HIV-associated co-infections such as tuberculosis (TB), hepatitis, and malaria have emerged as HIV research has become increasingly global in nature...
  28. SIMULATION OF PROTON AND HYDRIDE TRANSFER IN ENZYMES
    Sharon Hammes Schiffer; Fiscal Year: 2010
    ..of these studies are relevant to public health because the elucidation of the mechanisms will facilitate the development of more effective drugs for a broad range of diseases, including cancer, asthma, malaria, and rheumatoid arthritis.
  29. Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib
    Richard W Scott; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malaria is a global disease causing >500 million clinical cases and >1 million deaths each year. Moreover, drug resistant Plasmodium falciparum has become a major problem...
  30. Molecular epidemiology of drug resistance and population genetic structure of Pla
    Fangli Lu; Fiscal Year: 2013
    Project Summary/Abstract Malaria remains a serious public health problem in China...
  31. Malaria vaccines modified with TLR agonist adjuvant
    Elizabeth H Nardin; Fiscal Year: 2010
    PROJECT SUMMARY/ABSTRACT The potential efficacy of malaria vaccines have been demonstrated experimentally in humans immunized with irradiated sporozoites and in naturally infected individuals living in malaria endemic areas...
  32. Effector and Memory Anti-Malaria CD8+ Cell Responses
    FIDEL P ZAVALA; Fiscal Year: 2013
    CD8+ T cells play a major protective role in immunity to malaria infection by inhibiting the development of liver stages...
  33. A semi field trial test on efficacy of transgenic antimalarial biocontrol fungi
    Raymond J St Leger; Fiscal Year: 2013
    ..by applicant): Around 46% of the Worlds population lives in areas where mosquito-borne diseases including malaria, filariasis, viral encephalitides, dengue and yellow fever are endemic...
  34. IRS insecticides for malaria control and child neurodevelopment in South Africa
    Brenda Eskenazi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Every year, 250 million people are infected with malaria, resulting in 880,000 deaths, primarily to African children under age five...
  35. Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virus
    Charles M Rice; Fiscal Year: 2013
    ..serves as the reservoir for several important pathogens, including hepatitis B (HBV) and C viruses (HCV) and the malaria parasites, all of which represent serious global health problems...
  36. Development of a Chloroquine Replacement Drug
    MICHAEL KEVIN RISCOE; Fiscal Year: 2010
    ..Specific Challenge Topic, 15-AI-103* Develop drugs for neglected tropical diseases, with a special emphasis on malaria. With regard to the annual toll of people killed, malaria remains one of the deadliest diseases in the world ..
  37. Human T Cell Immunology of Plasmodium Vivax Malaria
    Anthony P Cannella; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malaria, caused by four Plasmodium species transmitted between humans and Anopheles mosquitoes, continues to be a major global public health problem...
  38. The role of Histidine rich protein II in cerebral malaria
    Priya Pal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malaria parasites cause ~1.2 million deaths annually...
  39. IeDEA West -Africa collaboration
    Francois Dabis; Fiscal Year: 2013
    ..address the following topics: retention in care, natural history of HIV-2 and HIV-1/HIV-2 infections, cancer, malaria, hepatitis B, pregnancy outcomes, pharmacovigilance, adolescent and pediatric access and efficiency of care...
  40. Role of Protective and Pathogenic B cells in Modulating Pediatric Severe Malaria
    Tom Were; Fiscal Year: 2013
    ..provided by applicant): Severe malarial anemia (SMA) is the most common clinical manifestation of severe malaria in infants and young children living in holoendemic Plasmodium falciparum transmission areas...
  41. Arginine, Nitric Oxide, and Severe Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
    ..We concluded that NO and NOS2 are protective against development of severe malaria. NO has antimicrobial effects in vitro against a wide variety of organisms including Plasmodium falciparum, and ..
  42. Understanding the malaria-poverty vicious circle
    MARCIA CALDAS DE CASTRO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Understanding the malaria-poverty vicious circle 6...
  43. INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMS
    Marcia B Goldberg; Fiscal Year: 2012
    ..defense, antiviral agents, and retrovirology;(3) parasitology, including pathogenesis, chloroquine resistance of malaria, parasite-cell interactions, and host defense;(4) immunology, including complement, T cells, B cells, and ..
  44. Antimalarial Pharmacology in HIV Coinfected Children and Pregnant Women in Uganda
    Sunil Parikh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malaria and HIV infection are two of the most important health challenges of our time...
  45. The role of the interaction between the C-terminal domain of RNA pol II and a his
    Uchechi E Ukaegbu; Fiscal Year: 2012
    ..between the C-terminal domain of RNA pol II and a histone methyltransferase in mediating epigenetic memory in malaria virulence genes Plasmodium falciparum is responsible for the most acute and severe form of human malaria...
  46. The function(s) of serpin-2 in mosquito immunity and physiology
    Kristin Michel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Malaria control and eradication strategies continue to primarily rely on vector control that is stymied by insecticide resistance in vector populations...
  47. HOST IMMUNITY TO EBV INFECTION IN VITRO AND IN VIVO
    David A Thorley-Lawson; Fiscal Year: 2013
    ..falciparum infection. Currently, we lack a comprehensive explanation for the role of EBV and malaria in eBL pathogenesis. We hypothesize that eBL arises from two converging events in the GC...
  48. Identification of G6PD inhibitors for the development of novel antimalarial drugs
    Lars Bode; Fiscal Year: 2010
    Tropical malaria, caused by the parasite Plasmodium falciparum, is responsible for up to three million deaths each year...
  49. Pilot studies of the molecular epidemiology of drug-resistant malaria in Myanmar
    Christopher V Plowe; Fiscal Year: 2013
    ..Organization (WHO) is coordinating an aggressive effort to contain artemisinin resistant Plasmodium falciparum malaria in Southeast Asia before it spreads from its recent site of emergence in Western Cambodia...
  50. Synthetic Oligosaccharides for Probing Infection and Innate Immunity
    Geert Jan Boons; Fiscal Year: 2013
    ..falciparum has been linked to excessive production of cytokines leading to the pathology of malaria. Furthermore, LPS in blood of infected patients has been linked to sepsis...
  51. Studies of Isoprenoid Biosynthesis
    CHARLES DALE POULTER; Fiscal Year: 2013
    ..the pathway have a long history as drugs, including more recent examples such as taxol (cancer) and artemisinin (malaria)...
  52. Point-of-care telemedicine units for surveillance of infectious diseases
    Karin Nielsen; Fiscal Year: 2010
    ..b>Malaria, tuberculosis, HIV disease and gastrointestinal illnesses pose 2/3 of the world population at risk...
  53. Systematic analysis of cell death regulation in mosquitoes
    Lei Zhou; Fiscal Year: 2009
    ..It has been implicated in the infectious life cycle of a variety of pathogens, such as the malaria parasite and the West Nile virus, in mosquitoes...
  54. FOSMIDOMYCIN RESISTANCE IN PLASMODIUM FALCIPARUM
    AUDREY RAGAN ODOM; Fiscal Year: 2013
    ..provided by applicant): Plasmodium falciparum is a protozoan pathogen that causes the deadliest form of malaria. Malaria has a tremendous impact on human health worldwide, causing nearly one million deaths per year...
  55. Function of Laccases in Anopheles gambiae
    Michael R Kanost; Fiscal Year: 2010
    ..have a tremendous human health impact, and Anopheles gambiae is particularly important as the major vector of malaria in Africa...
  56. The role of the terminal complement pathway in experimental cerebral malaria.
    Theresa N Ramos; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Malaria remains one of the most deadly infectious diseases throughout the developing world especially among children [1]...
  57. Transcriptomics and Population Genetics of Mosquito Resistance to Pyrethroids
    Mariangela Bonizzoni; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The World Health Organization (WHO) estimates 500 million clinical cases of malaria and about one million deaths per year. The majority of malaria morbidity and mortality occurs in sub-Saharan Africa...
  58. Perinatal Exposure to Environmental DDT and Risk of Metabolic Syndrome
    Michele La Merrill; Fiscal Year: 2012
    ..DDT was used extensively in the US until 1972 and is still much used worldwide in malaria control...
  59. Highly finished chromosome-based genome assembly for Anopheles gambiae
    Igor V Sharakhov; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The African malaria mosquito Anopheles gambiae, because of its epidemiological importance, was the first disease vector sequenced. In order to perform full genome annotation for An...
  60. Malaria treatment outcomes and pharmacokinetics in HIV-infected pregnant women
    MYAING MYAING NYUNT; Fiscal Year: 2010
    ..is the leading drug recommended by the World Health Organization (WHO) for the treatment of uncomplicated malaria caused by Plasmodium falciparum...
  61. Gamete membrane adhesion and fusion during fertilization
    William J Snell; Fiscal Year: 2013
    ..Our discovery of HAP2 already has had an unexpected impact in malaria fertilization research...
  62. Purine Pathways and Inhibitor Design in Plasmodium
    Vern L Schramm; Fiscal Year: 2012
    Plasmodium falciparum is the leading cause of death from malaria, taking the lives of over a million children and causing clinical illness in 300 to 500 million people each year...
  63. Plasmodium Genus and P. falciparum - P. vivax FISH Assays
    Jyotsna Shah; Fiscal Year: 2009
    ..Hybridization (P-Genus FISH) assay targeted to ribosomal RNA (rRNA) is a method that detects all the species of malaria on an air-dried blood smear. PFV-FISH assay is a dual probe assay for detecting and differentiating P...
  64. Role of chemokines in astro-neuronal activation in cerebral malaria
    Monique Stins; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Malaria carries a clinical burden of up to 200 million episodes in Africa alone and a severe complication is cerebral malaria (CM), often leading to coma and death...
  65. TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWI
    CHRISTOPHER PLOWE; Fiscal Year: 2003
    ..TS shares its mechanism of action with pyrimethamine-sulfadoxine (PS) and other antifolate drugs used to treat malaria, which is responsible for an estimated 2.7 million deaths in Africa each year...
  66. IMPACT OF TS PROPHYLAXIS ON ANTIFOLATE RESISTANT MALARIA
    James Kublin; Fiscal Year: 2000
    ..fellow at the University of Maryland, and is currently conducting field and laboratory research on drug resistant malaria in Malawi, Central Africa...
  67. Preventing Pregnancy Malaria: Maternal-Infant Outcomes
    Michal Fried; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Malaria during pregnancy kills thousands of mothers and hundreds of thousands of infants each year, so prevention is essential, but current regimens are losing efficacy to drug-resistant parasites...
  68. Improving Production of Attenuated Malaria Sporozoite Vaccines through Genetic Mo
    Peter Billingsley; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Malaria causes an estimated 500 million clinical cases and up to 2.7 million deaths per annum, reduces the GDP of Africa by >1% and is a serious risk for travelers including military personnel...
  69. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): 'Cerebral malaria'is a clinical syndrome consisting of coma not attributable to convulsions, hypoglycemia, or meningitis in patients with P. falciparum parasitemia...
  70. Dual Function Acridones as A New Antimalarial Chemotype
    Jane X Kelly; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Malaria remains one of the world's deadliest diseases, destroying lives by the millions and staggering families, communities and even nations with a burden that crushes hope...
  71. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Despite decades of effort to conquer malaria, it remains a leading cause of death due to a single infectious agent...
  72. BIOENERGETICS AND PROTON PUMPS IN MALARIA PARASITES
    Akhil Vaidya; Fiscal Year: 2007
    ..of charging the plasma membrane with an electrochemical gradient for such transport remains virtually unknown in malaria parasites...
  73. Potency of cryopreserved, irradiated sporozoite vaccine
    Stephen Hoffman; Fiscal Year: 2005
    b>Malaria causes an estimated 500 million clinical cases and up to 2.7 million deaths annually, is responsible for a loss of greater than 1% of GDP in Africa annually, and is a serious concern for travelers and military personnel...
  74. Research Training for Cambodian Scientists in Effective*
    William Rogers; Fiscal Year: 2006
    In Cambodia, malaria is the 3rd leading cause for outpatient clinic visits and the most common cause of deaths in hospitalized patients...
  75. Cognitive and Neurologic Sequelae in Cerebral Malaria
    Chandy John; Fiscal Year: 2007
    ..between serum IL-10 and TNF-c_ levels and neurologic and neuropsychologic deficits in children with cerebral malaria (CM). Malaria is the leading cause of death in children under 5 years of age in Uganda...
  76. Severe falciparum malaria: mechanisms of hypoargininemia
    Bert Lopansri; Fiscal Year: 2006
    ..the role of L-arginine as substrate for nitric oxide synthesis in the pathophysiology of severe falciparum malaria. Globally, malaria causes more morbidity and mortality than any other parasitic disease with most deaths ..
  77. Cerebral Malaria Associated Neurological Disorders in India
    Jonathan Stiles; Fiscal Year: 2005
    ..5 million annual deaths. P. falciparum is the most lethal species among the four human malaria parasites (P. falciparum, P. vivax, P. malariae, P...
  78. Congenital and neonatal malaria in Mali
    Abdoulaye Djimde; Fiscal Year: 2006
    ..Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. Malaria claims nearly 3 million lives per year, 90% of whom are children under the age of 5 years living in sub-Saharan ..
  79. Fighting Malaria with Microfinance: Evidence from India
    Alessandro Tarozzi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Insecticide-treated bednets (ITNs) are one of the most effective means of malaria prevention, particularly among pregnant women and young children...
  80. CR1 Polymorphisms and Susceptibility to Severe Malaria
    JOANN MOULDS; Fiscal Year: 2002
    DESCRIPTION (provided by the applicant): Plasmodium falciparum malaria is one of the most important infectious diseases affecting the human population and is a multi-factorial process influenced by both parasite virulence factors and ..