onchocerciasis

Summary

Summary: Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.

Top Publications

  1. pmc Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: final results of a study in Mali and Senegal
    Mamadou O Traoré
    Direction nationale de la santé, Bamako, Mali
    PLoS Negl Trop Dis 6:e1825. 2012
  2. pmc Impact of long-term treatment of onchocerciasis with ivermectin in Kaduna State, Nigeria: first evidence of the potential for elimination in the operational area of the African Programme for Onchocerciasis Control
    Afework Hailemariam Tekle
    African Programme for Onchocerciasis Control, WHO APOC P, O, Box 01 B, P, 549, Ouagadougou 01, Burkina Faso
    Parasit Vectors 5:28. 2012
  3. pmc African Programme For Onchocerciasis Control 1995-2015: model-estimated health impact and cost
    Luc E Coffeng
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 7:e2032. 2013
  4. ncbi Lymphatic filariasis and onchocerciasis
    Mark J Taylor
    Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet 376:1175-85. 2010
  5. pmc Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal
    Lamine Diawara
    Ministère de Santé et de Prévention Médicale, Dakar, Senegal
    PLoS Negl Trop Dis 3:e497. 2009
  6. ncbi Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
    J Gardon
    Antenne ORSTOM auprès du Centre Pasteur, Yaounde, Cameroon
    Lancet 350:18-22. 1997
  7. ncbi Elimination of Onchocercia volvulus transmission in the Santa Rosa focus of Guatemala
    Kim A Lindblade
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA
    Am J Trop Med Hyg 77:334-41. 2007
  8. pmc Can ivermectin mass treatments eliminate onchocerciasis in Africa?
    M Winnen
    Department of Public Health, Erasmus University, Rotterdam, The Netherlands
    Bull World Health Organ 80:384-91. 2002
  9. ncbi Onchocerciasis: the clinical and epidemiological burden of skin disease in Africa
    M E Murdoch
    Department of Biology, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BB, UK
    Ann Trop Med Parasitol 96:283-96. 2002
  10. pmc Onchocerciasis in the Americas: from arrival to (near) elimination
    Ken Gustavsen
    Corporate Responsibility, Merck, 1 Merck Drive, WS2A 56, Whitehouse Station, New Jersey 08889, USA
    Parasit Vectors 4:205. 2011

Detail Information

Publications314 found, 100 shown here

  1. pmc Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: final results of a study in Mali and Senegal
    Mamadou O Traoré
    Direction nationale de la santé, Bamako, Mali
    PLoS Negl Trop Dis 6:e1825. 2012
    Mass treatment with ivermectin controls onchocerciasis as a public health problem, but it was not known if it could also interrupt transmission and eliminate the parasite in endemic foci in Africa where vectors are highly efficient...
  2. pmc Impact of long-term treatment of onchocerciasis with ivermectin in Kaduna State, Nigeria: first evidence of the potential for elimination in the operational area of the African Programme for Onchocerciasis Control
    Afework Hailemariam Tekle
    African Programme for Onchocerciasis Control, WHO APOC P, O, Box 01 B, P, 549, Ouagadougou 01, Burkina Faso
    Parasit Vectors 5:28. 2012
    b>Onchocerciasis can be effectively controlled as a public health problem by annual mass drug administration of ivermectin, but it was not known if ivermectin treatment in the long term would be able to achieve elimination of onchocerciasis ..
  3. pmc African Programme For Onchocerciasis Control 1995-2015: model-estimated health impact and cost
    Luc E Coffeng
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 7:e2032. 2013
    b>Onchocerciasis causes a considerable disease burden in Africa, mainly through skin and eye disease. Since 1995, the African Programme for Onchocerciasis Control (APOC) has coordinated annual mass treatment with ivermectin in 16 countries...
  4. ncbi Lymphatic filariasis and onchocerciasis
    Mark J Taylor
    Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet 376:1175-85. 2010
    Lymphatic filariasis and onchocerciasis are parasitic helminth diseases that constitute a serious public health issue in tropical regions...
  5. pmc Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal
    Lamine Diawara
    Ministère de Santé et de Prévention Médicale, Dakar, Senegal
    PLoS Negl Trop Dis 3:e497. 2009
    Mass treatment with ivermectin is a proven strategy for controlling onchocerciasis as a public health problem, but it is not known if it can also interrupt transmission and eliminate the parasite in endemic foci in Africa where vectors ..
  6. ncbi Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
    J Gardon
    Antenne ORSTOM auprès du Centre Pasteur, Yaounde, Cameroon
    Lancet 350:18-22. 1997
    In 1995, the World Bank launched an African Programme for Onchocerciasis Control to eliminate Onchocerca volvulus disease from 19 African countries by means of community-based ivermectin treatment (CBIT)...
  7. ncbi Elimination of Onchocercia volvulus transmission in the Santa Rosa focus of Guatemala
    Kim A Lindblade
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA
    Am J Trop Med Hyg 77:334-41. 2007
    ..We applied the 2001 World Health Organization (WHO) elimination criteria in the Santa Rosa focus of onchocerciasis transmission in Guatemala (10,923 persons at risk)...
  8. pmc Can ivermectin mass treatments eliminate onchocerciasis in Africa?
    M Winnen
    Department of Public Health, Erasmus University, Rotterdam, The Netherlands
    Bull World Health Organ 80:384-91. 2002
    ..To elucidate the conditions in which mass treatment with ivermectin reduces the transmission of Onchocerca volvulus sufficiently to eliminate infection from an African community...
  9. ncbi Onchocerciasis: the clinical and epidemiological burden of skin disease in Africa
    M E Murdoch
    Department of Biology, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BB, UK
    Ann Trop Med Parasitol 96:283-96. 2002
    ..skin disease throughout the African region and hence provide an objective basis for the rational planning of onchocerciasis control in the area...
  10. pmc Onchocerciasis in the Americas: from arrival to (near) elimination
    Ken Gustavsen
    Corporate Responsibility, Merck, 1 Merck Drive, WS2A 56, Whitehouse Station, New Jersey 08889, USA
    Parasit Vectors 4:205. 2011
    b>Onchocerciasis (river blindness) is a blinding parasitic disease that threatens the health of approximately 120 million people worldwide...
  11. ncbi Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College London, London, UK
    Lancet Infect Dis 8:310-22. 2008
    The broad-spectrum antiparasitic drug ivermectin was licensed for use against onchocerciasis in 1987, yet the mechanisms by which it exerts a fast decrease and long-lasting suppression of Onchocerca volvulus microfilaridermia, and ..
  12. pmc Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys
    Sebastien D S Pion
    Unité Mixte de Recherche 145, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, Montpellier, France
    PLoS Negl Trop Dis 3:e461. 2009
    We sought to evaluate the relationship between onchocerciasis prevalence and that of epilepsy using available data collected at community level.
  13. ncbi Elimination of human onchocerciasis: history of progress and current feasibility using ivermectin (Mectizan(®)) monotherapy
    E W Cupp
    Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA
    Acta Trop 120:S100-8. 2011
    We review and analyze approaches over a 65 year period that have proven successful for onchocerciasis control in several different epidemiological settings...
  14. ncbi Control of onchocerciasis in Africa: threshold shifts, breakpoints and rules for elimination
    Hans P Duerr
    Dept of Medical Biometry, University of Tuebingen, Westbahnhofstrasse 55, 72070 Tuebingen, Germany
    Int J Parasitol 41:581-9. 2011
    Control of onchocerciasis in Africa is currently based on annual community-directed treatment with ivermectin (CDTI) which has been assumed to be not efficient enough to bring about elimination...
  15. pmc Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulus
    Mike Y Osei-Atweneboana
    Institute of Parasitology, McGill University, Montreal, Canada
    PLoS Negl Trop Dis 5:e998. 2011
    Ivermectin (IVM) has been used in Ghana for over two decades for onchocerciasis control. In recent years there have been reports of persistent microfilaridermias despite multiple treatments...
  16. pmc Uncertainty surrounding projections of the long-term impact of ivermectin treatment on human onchocerciasis
    Hugo C Turner
    Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, Norfolk Place, London, United Kingdom
    PLoS Negl Trop Dis 7:e2169. 2013
    ..have indicated that annual (or biannual) ivermectin distribution may lead to local elimination of human onchocerciasis in certain African foci...
  17. pmc Population biology of human onchocerciasis
    M G Basáñez
    Wellcome Trust Centre for Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, UK
    Philos Trans R Soc Lond B Biol Sci 354:809-26. 1999
    Human onchocerciasis (river blindness) is the filarial infection caused by Onchocerca volvulus and transmitted among people through the bites of the Simulium vector...
  18. ncbi Onchocerca-Simulium interactions and the population and evolutionary biology of Onchocerca volvulus
    Maria Gloria Basanez
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    Adv Parasitol 68:263-313. 2009
    ..we focus on Onchocerca-Simulium interactions with particular reference to the transmission dynamics of human onchocerciasis. A wide range of simuliid species may act as vectors of Onchocerca volvulus, each exerting their own influence ..
  19. ncbi Models for the population biology and control of human onchocerciasis
    M G Basáñez
    Dept of Infectious Disease Epidemiology, Imperial College School of Medicine St Mary s Campus, Norfolk Place, W2 1PG, London, UK
    Trends Parasitol 17:430-8. 2001
    ..Here, we review the development of models concerning onchocerciasis and discuss the various approaches that have been used, presenting a deterministic framework with parameter ..
  20. pmc Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis
    Francesca Tamarozzi
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Parasit Vectors 5:53. 2012
    ..superior to ivermectin and of great potential as an alternative approach for the treatment and control of onchocerciasis, particularly in areas of Loa loa co-endemicity...
  21. ncbi Onchocerciasis
    G Burnham
    Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Lancet 351:1341-6. 1998
    An estimated 17.7 million persons, most of them in Africa, are infected with the parasite Onchocerca volvulus. Onchocerciasis has caused blindness in 270,000 and left another 500,000 with severe visual impairment...
  22. pmc Onchocerciasis: the pre-control association between prevalence of palpable nodules and skin microfilariae
    Luc E Coffeng
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 7:e2168. 2013
    The prospect of eliminating onchocerciasis from Africa by mass treatment with ivermectin has been rejuvenated following recent successes in foci in Mali, Nigeria and Senegal...
  23. pmc Density-dependent mortality of the human host in onchocerciasis: relationships between microfilarial load and excess mortality
    Martin Walker
    Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 6:e1578. 2012
    ..Determining the functional form of such relationship would contribute to quantify the population impact of mass microfilaricidal treatment...
  24. ncbi Diagnostic value of nodule palpation in onchocerciasis
    H P Duerr
    Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Trans R Soc Trop Med Hyg 102:148-54. 2008
    ..is the major diagnostic tool for determining the prevalence of infection in areas of the African Programme for Onchocerciasis Control (APOC) and is recommended for identifying communities at risk and selecting them for mass drug ..
  25. ncbi Sampling strategies to detect anthelmintic resistance: the perspective of human onchocerciasis
    Thomas S Churcher
    Department of Infectious Disease Epidemiology, St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    Trends Parasitol 25:11-7. 2009
    ....
  26. ncbi Elimination of onchocerciasis from Africa: possible?
    Charles D Mackenzie
    Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA
    Trends Parasitol 28:16-22. 2012
    Human onchocerciasis, a parasitic disease found in 28 African countries, six Latin American countries and Yemen, causes blindness and severe dermatological problems...
  27. ncbi Evidence for suppression of Onchocerca volvulus transmission in the Oaxaca focus in Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Boulevard del Maestro Esquina Elías Piña, Col Narciso Mendoza, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 78:147-52. 2008
    ..Taken together, these data suggest that transmission has been suppressed in the four communities...
  28. ncbi The Onchocerciasis Elimination Program for the Americas (OEPA)
    M Sauerbrey
    Onchocerciasis Elimination Program for the Americas OEPA, 14 Calle 3 51 Zona 10, Edificio Murano Center, Oficina 1401, Guatemala City, Guatemala
    Ann Trop Med Parasitol 102:25-9. 2008
    Human onchocerciasis (river blindness) occurs in 13 foci distributed among six countries in Latin America (Brazil, Colombia, Ecuador, Guatemala, Mexico and Venezuela), where about 500,000 people are considered at risk...
  29. ncbi A rapid mapping technique for the prevalence and distribution of onchocerciasis: a Cameroon case study
    P Ngoumou
    OCP, Ministry of Public Health, Yaounde, Cameroon
    Ann Trop Med Parasitol 88:463-74. 1994
    A rapid and cheap method for mapping the endemicity levels of onchocerciasis in both forest and savanna areas, where the vectors are members of the Simulium damnosum complex, is described...
  30. ncbi The elimination of the vector Simulium neavei from the Itwara onchocerciasis focus in Uganda by ground larviciding
    R Garms
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Acta Trop 111:203-10. 2009
    The Itwara focus of onchocerciasis covers an area of approximately 600 km(2) in western Uganda about 20 km north of Fort Portal. The vector is Simulium neavei, whose larvae and pupae live in a phoretic association on freshwater crabs...
  31. ncbi Progress towards the elimination of onchocerciasis as a public-health problem in Uganda: opportunities, challenges and the way forward
    R Ndyomugyenyi
    Vector Control Division, Ministry of Health, PO Box 1661, Kampala, Uganda
    Ann Trop Med Parasitol 101:323-33. 2007
    The national onchocerciasis-control programme in Uganda successfully eliminated Simulium neavei s.s. from the Itwara focus in 1997, by monthly ground spraying with larvicidal temophos (Abate)...
  32. ncbi Mortality from epilepsy in an onchocerciasis-endemic area in West Uganda
    C Kaiser
    Basic Health Services Kabarole and Bundibugyo Districts, Fort Portal, Uganda
    Trans R Soc Trop Med Hyg 101:48-55. 2007
    ..from epilepsy was investigated in a rural area of West Uganda where epilepsy is found to be closely linked to onchocerciasis. Thirty-three female and 28 male patients (age range 4-58 years, median 15 years) were identified in a ..
  33. ncbi Lymphatic filariasis in western Ethiopia with special emphasis on prevalence of Wuchereria bancrofti antigenaemia in and around onchocerciasis endemic areas
    Welelta Shiferaw
    Department of Microbiology, Immunology and Parasitology DMIP Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    Trans R Soc Trop Med Hyg 106:117-27. 2012
    ..6% respectively. Significantly higher (χ(2)=49.6; P<0.01) prevalence of antigenaemia was noted in known onchocerciasis endemic districts (4.7%) compared to non-onchocerciasis endemic districts (2.3%)...
  34. ncbi The African Programme for Onchocerciasis Control: impact on onchocercal skin disease
    G A Ozoh
    Department of Dermatology, University of Nigeria Teaching Hospital, Ituku ozala, Nigeria
    Trop Med Int Health 16:875-83. 2011
    To assess the long-term impact of the African Programme for Onchocerciasis Control on itching and onchocercal skin disease (OSD).
  35. pmc Human ocular filariasis: further evidence on the zoonotic role of Onchocerca lupi
    Domenico Otranto
    Dipartimento di Sanità Pubblica Veterinaria e Zootecnia, Universita degli Studi di Bari, Bari, Valenzano, Italy
    Parasit Vectors 5:84. 2012
    ..Other Onchocerca spp. have been sporadically reported as zoonotic agents. Cases of canine onchocerciasis caused by Onchocerca lupi are on the rise in the United States and Europe...
  36. pmc Seventeen years of annual distribution of ivermectin has not interrupted onchocerciasis transmission in North Region, Cameroon
    Moses N Katabarwa
    The Carter Center, Atlanta, Georgia 30307, USA
    Am J Trop Med Hyg 85:1041-9. 2011
    We studied onchocerciasis transmission and impact on ocular morbidity in three health districts in North Region, Cameroon, where annual mass ivermectin treatment has been provided for 12-17 years...
  37. ncbi Adverse systemic reactions to treatment of onchocerciasis with ivermectin at normal and high doses given annually or three-monthly
    Joseph Kamgno
    Laboratoire mixte IRD CPC d Epidémiologie et de Santé publique, Centre Pasteur du Cameroun, B P 1274, Yaounde, Cameroon
    Trans R Soc Trop Med Hyg 98:496-504. 2004
    ..and effects on transmission of large-scale 3-monthly treatments with standard doses of ivermectin for onchocerciasis control...
  38. pmc Lack of active Onchocerca volvulus transmission in the northern Chiapas focus of Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 83:15-20. 2010
    The northern Chiapas onchocerciasis focus has undergone 11 years of ivermectin mass treatment...
  39. ncbi Assessment and monitoring of onchocerciasis in Latin America
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Ciudad Reynosa, Tamaulipas, Mexico
    Adv Parasitol 77:175-226. 2011
    b>Onchocerciasis has historically been one of the leading causes of infectious blindness worldwide. It is endemic to tropical regions both in Africa and Latin America and in the Yemen...
  40. ncbi Does onchocerciasis transmission take place in hypoendemic areas? a study from the North Region of Cameroon
    Moses N Katabarwa
    The Carter Center, Emory University, Atlanta, GA, USA
    Trop Med Int Health 15:645-52. 2010
    Community-directed treatment with ivermectin (CDTI) for onchocerciasis control is targeted to meso and hyperendemic areas in Africa. Below the threshold, communities are considered hypoendemic and, mass treatment is not recommended...
  41. ncbi Factors affecting the attrition of community-directed distributors of ivermectin, in an onchocerciasis-control programme in the Imo and Abia states of south-eastern Nigeria
    E C Emukah
    National Office, Global 2000 Program, The Carter Center, Jos, Nigeria
    Ann Trop Med Parasitol 102:45-51. 2008
    In areas of Nigeria where onchocerciasis is endemic, community-directed distributors (CDD) distribute ivermectin annually, as part of the effort to control the disease...
  42. ncbi The impact of ivermectin treatment alone and when in parallel with Simulium neavei elimination on onchocerciasis in Uganda
    Richard Ndyomugyenyi
    National Onchocerciasis Control Programme, Vector Control Division, Kampala, Uganda
    Trop Med Int Health 9:882-6. 2004
    ..2002 in Kigoyera parish in Kyenjojo district, where ivermectin treatment had been the strategy to control onchocerciasis since 1991 and was later supplemented with Simulium neavei control in 1995 and subsequent elimination; and in ..
  43. ncbi The relationships between the burden of adult parasites, host age and the microfilarial density in human onchocerciasis
    H P Duerr
    Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
    Int J Parasitol 34:463-73. 2004
    ..The data of 169 patients in Burkina Faso and 182 patients in Liberia represent savannah and forest onchocerciasis in West Africa, respectively...
  44. ncbi Epidemiology and control of onchocerciasis: the threshold biting rate of savannah onchocerciasis in Africa
    Hans P Duerr
    Department of Medical Biometry, University of Tuebingen, Westbahnhofstr 55, 72070 Tuebingen, Germany
    Int J Parasitol 40:641-50. 2010
    Control of onchocerciasis currently focuses on community-directed treatment with the microfilaricide ivermectin which effectively kills Onchocerca volvulus microfilariae in the human host...
  45. ncbi Three probable cases of Loa loa encephalopathy following ivermectin treatment for onchocerciasis
    M Boussinesq
    Antenne de l Institut Francais de Recherche Scientifique pour le Developpement en Cooperation ORSTOM aupres du Centre Pasteur du Cameroun, Yaounde, Cameroon
    Am J Trop Med Hyg 58:461-9. 1998
    ..Before launching mass ivermectin distribution programs to control onchocerciasis in central Africa, communities in which the intensity of concomitant L...
  46. pmc Repositioning of an existing drug for the neglected tropical disease Onchocerciasis
    Christian Gloeckner
    Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:3424-9. 2010
    b>Onchocerciasis, or river blindness, is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus that affects more than 37 million people, mainly in third world countries...
  47. ncbi Polymerase chain reaction monitoring of transmission of Onchocerca volvulus in two endemic states in Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 70:38-45. 2004
    ..These findings suggest that while substantial progress towards elimination has been made in Mexico, it may be necessary to modify ivermectin distribution strategies to eliminate transmission in areas where transmission persists...
  48. ncbi Onchocercosis: a newly recognized disease in dogs
    Tamás Sréter
    Laboratories for Parasites, Fish, Bee and Wildlife Diseases, Veterinary Diagnostic Directorate, Central Agricultural Office, H 1149, Budapest, Hungary
    Vet Parasitol 151:1-13. 2008
    ..As infections in dogs may provide a practical experimental system, further studies should be encouraged to try to establish experimental Onchocerca infections in dogs...
  49. ncbi Ivermectin: 25 years and still going strong
    S Omura
    The Kitasato Institute, Tokyo, Japan
    Int J Antimicrob Agents 31:91-8. 2008
    ....
  50. pmc Interruption of transmission of Onchocerca volvulus in the Oaxaca focus, Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 83:21-7. 2010
    All endemic communities of the Oaxaca focus of onchocerciasis in southern Mexico have been treated annually or semi-annually with ivermectin since 1994. In-depth epidemiologic assessments were performed in communities during 2007 and 2008...
  51. pmc Required duration of combined annual ivermectin treatment and vector control in the Onchocerciasis Control Programme in west Africa
    A P Plaisier
    Department of Public Health, Faculty of Medicine, Erasmus University Rotterdam, Netherlands
    Bull World Health Organ 75:237-45. 1997
    In the extension areas of the Onchocerciasis Control Programme in West Africa, aerial larviciding is supplemented with annual ivermectin treatment, mainly to achieve better control of morbidity...
  52. ncbi A rapid-format antibody card test for diagnosis of onchocerciasis
    G J Weil
    Infectious Diseases Division, Barnes Jewish Hospital, St Louis, MO 63110, USA
    J Infect Dis 182:1796-9. 2000
    Improved methods are needed for field diagnosis of onchocerciasis, to support efforts aimed at elimination of the disease...
  53. ncbi P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus
    Catherine Bourguinat
    Institute of Parasitology, McGill University, 21 111 Lakeshore Road, Sainte Anne de Bellevue, Quebec, Canada H9X3V9
    Mol Biochem Parasitol 158:101-11. 2008
    Ivermectin (IVM) is the only safe drug for mass-treatment of onchocerciasis. IVM resistance has been reported in gastrointestinal nematode parasites of animals...
  54. ncbi Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria
    N W Brattig
    Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany
    Microbes Infect 6:113-28. 2004
    Onchocerca volvulus is a tissue-invasive parasitic nematode causing skin and eye pathology in human onchocerciasis. The filariae habour abundant intracellular Wolbachia bacteria, now recognised as obligatory symbionts, and therefore ..
  55. ncbi Blackfly vectors of zoonotic onchocerciasis in Japan
    H Takaoka
    Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    Med Vet Entomol 26:372-8. 2012
    ..Bain & Takaoka (Spirurida: Onchocercidae), a parasite of wild boar implicated in the aetiology of zoonotic onchocerciasis in Japan, and six other zoonotic Onchocerca species of this country are reviewed...
  56. ncbi Community-directed treatment with ivermectin in two Nigerian communities: an analysis of first year start-up processes, costs and consequences
    Obinna Onwujekwe
    Health Policy Research Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, P M B 01129, Enugu, Nigeria
    Health Policy 62:31-51. 2002
    ..the start-up processes, costs and consequences of community-directed treatment with ivermectin (CDTI) in two onchocerciasis endemic rural towns of Southeast Nigeria; namely Achi and Nike...
  57. ncbi Integrated rapid mapping of onchocerciasis and loiasis in the Democratic Republic of Congo: impact on control strategies
    Afework Hailemariam Tekle
    African Program for Onchocerciasis Control, Epidemiology and Vector Elimination, Rue Naba Zombre 1538, Sector 9 Door Number 1473, Ougadougou, Burkina Faso
    Acta Trop 120:S81-90. 2011
    b>Onchocerciasis can be effectively controlled by annual mass treatment with ivermectin in endemic communities...
  58. ncbi The Onchocerciasis Control Programme in West Africa (OCP)
    B Boatin
    UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
    Ann Trop Med Parasitol 102:13-7. 2008
    The Onchocerciasis Control Programme in West Africa (OCP) started operations in 1975...
  59. ncbi Field applicability of a rapid-format anti-Ov-16 antibody test for the assessment of onchocerciasis control measures in regions of endemicity
    Ettie M Lipner
    Office of Global Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 194:216-21. 2006
    ..A previously developed, specific, rapid-format immunochromatographic card test that detects immunoglobulin G4 to the recombinant Onchocerca volvulus antigen Ov-16 was modified to detect antibodies in whole blood...
  60. pmc The cost of annual versus biannual community-directed treatment of onchocerciasis with ivermectin: Ghana as a case study
    Hugo C Turner
    Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine St Mary s Campus, Imperial College London, Norfolk Place, London, United Kingdom
    PLoS Negl Trop Dis 7:e2452. 2013
    ..biannual (twice yearly) mass community-directed treatment with ivermectin (CDTI) might improve the chances of onchocerciasis elimination in some African foci...
  61. pmc Association between onchocerciasis and epilepsy in the Itwara hyperendemic focus, West Uganda: controlling for time and intensity of exposure
    Christoph Kaiser
    Basic Health Services, Kabarole and Bundibugyo Districts, Fort Portal, Uganda
    Am J Trop Med Hyg 85:225-8. 2011
    In 38 pairs of epilepsy patients and controls matched for time and intensity of exposure to transmission of onchocerciasis, the presence of microfilariae in the skin of epilepsy patients was found insignificantly elevated compared with ..
  62. ncbi [Endemicity and clinical manifestations of onchocerciasis in the provinces of Cibitoke and Bubanza (Burundi)]
    E D Newell
    national de lutte contre l onchocercose, Bujumbura, Burundi
    Bull Soc Pathol Exot 90:353-7. 1997
    The prevalence and intensity of onchocerciasis in the endemic region of the provinces of Cibitoke and Bubanza (Burundi) have been determined through the examination of a sample of the population of 33 "collines" (administrative ..
  63. ncbi The elimination of the onchocerciasis vector from the island of Bioko as a result of larviciding by the WHO African Programme for Onchocerciasis Control
    S Traore
    African Programme for Onchocerciasis Control WHO APOC, 01 BP 549 Ouagadougou 01, Burkina Faso
    Acta Trop 111:211-8. 2009
    ..of Bioko is part of the Republic of Equatorial Guinea and is the only island in the World to have endemic onchocerciasis. The disease is hyperendemic and shows a forest-type epidemiology with low levels of blindness and high levels ..
  64. ncbi Individual host factors associated with Onchocerca volvulus microfilarial densities 15, 80 and 180 days after a first dose of ivermectin
    Sebastien D S Pion
    Unité Mixte de Recherche 145, Institut de Recherche pour le Développement and University of Montpellier 1, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Acta Trop 120:S91-9. 2011
    ..Data from two separate studies conducted in Cameroon on onchocerciasis patients treated for the first time with ivermectin were analyzed to identify host factors associated with ..
  65. ncbi Characteristics of persons who complied with and failed to comply with annual ivermectin treatment
    William R Brieger
    Department of International Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Trop Med Int Health 17:920-30. 2012
    To assess individual compliance with annual ivermectin treatment in onchocerciasis-endemic villages.
  66. pmc Zoonotic Onchocerca lupi infection in a 22-month-old child in Arizona: first report in the United States and a review of the literature
    Mark L Eberhard
    Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Trop Med Hyg 88:601-5. 2013
    ..A great deal more needs to be learned, including full host range and geographic distribution, before we fully understand O. lupi infections in animals and man...
  67. ncbi Cattle protected from onchocerciasis by ivermectin are highly susceptible to infection after drug withdrawal
    L M Njongmeta
    Veterinary Parasitology, Liverpool School of Tropical Medicine and Faculty of Veterinary Science, University of Liverpool, Pembroke Place, Liverpool L3 5QA, UK
    Int J Parasitol 34:1069-74. 2004
    Ivermectin administration is now the major tool in the control of human onchocerciasis (caused by Onchocerca volvulus) based on its suppression of microfilariae and hence the prevention of disease...
  68. ncbi Entomological evaluation by pool screen polymerase chain reaction of Onchocerca volvulus transmission in Ecuador following mass Mectizan distribution
    Angel G Guevara
    Laboratory of Clinical Investigation, Community Services Vozandes, Quito, Ecuador
    Am J Trop Med Hyg 68:222-7. 2003
    ..by pool screen polymerase chain reaction (PCR) amplification in the three river basins in Ecuador endemic for onchocerciasis. Mass distribution of ivermectin (Mectizan) resulted in dramatic declines in the prevalence of infected and ..
  69. ncbi Diagnostics in onchocerciasis: future challenges
    B A Boatin
    World Health Organization Onchocerciasis Control Programme in West Africa, Ouagadougou, Burkina Faso
    Ann Trop Med Parasitol 92:S41-5. 1998
    ..Given all these factors, the greater challenge in the area of diagnostics for onchocerciasis is to develop a less invasive, adequately sensitive, and equally specific diagnostic test, either to replace ..
  70. ncbi [Endemic disease and clinical manifestations of onchocerciasis in the province of Rutana (Burundi)]
    E D Newell
    Programme national de lutte contre l onchocercose, Programme de lutte contre les maladies transmissibles et carentielles L M T C, Bujumbura, Burundi
    Bull Soc Pathol Exot 90:107-10. 1997
    ..of Rutana (Burundi) a sample of the population was examined to determine the prevalence and intensity of onchocerciasis in this endemic region. In all, the area is hypoendemic with 7.9% of the population infected...
  71. ncbi The burden of onchocerciasis in Uganda
    R Ndyomugyenyi
    National Onchocerciasis Control Programme, Ministry of Health, Kampala, Uganda
    Ann Trop Med Parasitol 92:S133-7. 1998
    b>Onchocerciasis is far more prevalent and far more of a public-health and socio-economic problem in Uganda than it was thought to be a decade ago...
  72. ncbi Operational lessons from 20 years of the Mectizan Donation Program for the control of onchocerciasis
    B Thylefors
    Mectizan Donation Program, Decatur, GA 30030, USA
    Trop Med Int Health 13:689-96. 2008
    The donation of ivermectin (Mectizan, Merck & Co., Inc.) to control onchocerciasis (river blindness) was established in 1987 and has since gradually expanded to provide for >570 million treatments cumulatively over the past 20 ..
  73. ncbi Impact of parental onchocerciasis and intensity of transmission on development and persistence of Onchocerca volvulus infection in offspring: an 18 year follow-up study
    A K Kirch
    Institute for Tropical Medicine, University of Tubingen, Germany
    Parasitology 127:327-35. 2003
    ..Longitudinal follow up of children showed that during vector control activities by the Onchocerciasis Control Programme (OCP) and in low-level transmission areas, infection persisted at higher levels in children ..
  74. pmc Immunisation with a multivalent, subunit vaccine reduces patent infection in a natural bovine model of onchocerciasis during intense field exposure
    Benjamin L Makepeace
    Veterinary Parasitology Group, Liverpool School of Tropical Medicine and Faculty of Veterinary Science, University of Liverpool, Liverpool, United Kingdom
    PLoS Negl Trop Dis 3:e544. 2009
    Human onchocerciasis, caused by the filarial nematode Onchocerca volvulus, is controlled almost exclusively by the drug ivermectin, which prevents pathology by targeting the microfilariae...
  75. ncbi Eosinophils, eosinophil cationic protein and eosinophil-derived neurotoxin in serum and urine of patients with onchocerciasis coinfected with intestinal nematodes and in urinary schistosomiasis
    F W Tischendorf
    Department of Clinical Chemistry, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Acta Trop 72:157-73. 1999
    ..The highest serum ECP and serum and urinary EDN/EPX levels were observed in the hyperreactive form of onchocerciasis (sowda). Onchocerciasis patients and O...
  76. ncbi Controlling onchocerciasis by community-directed, ivermectin-treatment programmes in Uganda: why do some communities succeed and others fail?
    N M Katabarwa
    Global 2000 River Blindness Program, Carter Center, Kampala, Uganda
    Ann Trop Med Parasitol 94:343-52. 2000
    In Uganda, human onchocerciasis is controlled by annual, mass, community-directed, ivermectin-treatment programmes (CDITP) in all endemic communities where the prevalence of the disease is > or = 30%...
  77. ncbi Simultaneous administration of praziquantel, ivermectin and albendazole, in a community in rural northern Ghana endemic for schistosomiasis, onchocerciasis and lymphatic filariasis
    Francis Anto
    Navrongo Health Research Centre, Navrongo, Ghana
    Trop Med Int Health 16:1112-9. 2011
    ....
  78. ncbi Resistance and susceptibility in human onchocerciasis--beyond Th1 vs. Th2
    Achim Hoerauf
    Bernhard Nocht Institute of Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany
    Trends Parasitol 18:25-31. 2002
    As research progress has led to programs for the elimination of onchocerciasis as a public health problem, research must now be intensified to protect elimination efforts...
  79. ncbi Whither onchocerciasis control in Africa?
    D R Hopkins
    Am J Trop Med Hyg 72:1-2. 2005
  80. ncbi The role of Onchocerca volvulus in the development of epilepsy in a rural area of Tanzania
    Rebekka König
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Parasitology 137:1559-68. 2010
    Several reports indicate high prevalences of both onchocerciasis and epilepsy in some regions of Africa. This raises the question of whether these diseases are associated...
  81. ncbi Reduced genetic variation of an Onchocerca volvulus ABC transporter gene following treatment with ivermectin
    B F Ardelli
    Institute of Parasitology, Macdonald Campus, McGill University, 21 111 Lakeshore Road, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
    Trans R Soc Trop Med Hyg 101:1223-32. 2007
    ..Mass treatment with IVM is an integral component of the onchocerciasis control programmes...
  82. pmc Compliance with eight years of annual ivermectin treatment of onchocerciasis in Cameroon and Nigeria
    William R Brieger
    Department of International Health, The Johns Hopkins UniversityBloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21014, USA
    Parasit Vectors 4:152. 2011
    As the African Programme for Onchocerciasis Control (APOC) matured into its 10th year of ensuring community involvement in mass annual treatment of onchocerciasis with ivermectin, there was recognition of a need to study not only annual ..
  83. ncbi Adverse reactions following annual ivermectin treatment of onchocerciasis in Nigeria
    Wellington A Oyibo
    Department of Microbiology, Immunology and Parasitology, Faculty of Medicine, Addis Abbaba University, Addis Ababa, Ethiopia
    Int J Infect Dis 7:156-9. 2003
    ..As communities are empowered to distribute ivermectin, monitoring of adverse reactions by health care professionals is important in achieving the onchocerciasis control objectives through mass ivermectin therapy.
  84. ncbi Traditional kinship system enhanced classic community-directed treatment with ivermectin (CDTI) for onchocerciasis control in Uganda
    Moses N Katabarwa
    The Emory University Carter Center, 1149 Ponce de Leon Avenue, Atlanta GA 30306, USA
    Trans R Soc Trop Med Hyg 104:265-72. 2010
    The challenges of community-directed treatment with ivermectin (CDTI) for onchocerciasis control in Africa have been: maintaining a desired treatment coverage, demand for monetary incentives, high attrition of community distributors and ..
  85. ncbi The effect of 5 years of annual treatment with ivermectin (Mectizan) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic
    M H Kennedy
    Task Force for Child Survival, Mectizan Donation Program, 750 Commerce Drive, Decatur, GA 30030, USA
    Ann Trop Med Parasitol 96:297-307. 2002
    To assess the impact of 5 years of annual community treatment with ivermectin (Mectizan) on the prevalence of onchocerciasis and onchocerciasis-associated morbidity, data collected, before and after such treatment, in the village of Gami, ..
  86. ncbi Onchodermatitis
    Michele E Murdoch
    Watford General Hospital, Watford, UK
    Curr Opin Infect Dis 23:124-31. 2010
    ..This review is timely because awareness of the burden of disease from onchodermatitis has increased significantly over recent years. Recent progress in the field is reviewed with emphasis on publications within the past 2 years...
  87. ncbi Dracunculiasis, onchocerciasis, schistosomiasis, and trachoma
    Donald R Hopkins
    Health Programs, The Carter Center, 453 Freedom Pkwy, Atlanta, GA 30307, USA
    Ann N Y Acad Sci 1136:45-52. 2008
    The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a contributor to the ..
  88. ncbi Large-scale entomologic assessment of Onchocerca volvulus transmission by poolscreen PCR in Mexico
    Mario A Rodríguez-Pérez
    Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Cd Reynosa, Tamaulipas, Mexico
    Am J Trop Med Hyg 74:1026-33. 2006
    ..These data suggest that O. volvulus transmission in Mexico has been suppressed or brought to a level that may be insufficient to sustain the parasite population...
  89. pmc Successful interruption of transmission of Onchocerca volvulus in the Escuintla-Guatemala focus, Guatemala
    Rodrigo J Gonzalez
    Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala
    PLoS Negl Trop Dis 3:e404. 2009
    Elimination of onchocerciasis (river blindness) through mass administration of ivermectin in the six countries in Latin America where it is endemic is considered feasible due to the relatively small size and geographic isolation of ..
  90. ncbi Review of epidemiological studies searching for a relationship between onchocerciasis and epilepsy
    M Druet-Cabanac
    Institute of Neuroepidemiology and Tropical Neurology EA 3174, Limoges, France
    Neuroepidemiology 23:144-9. 2004
    A review and a meta-analysis of the available epidemiological literature for evidence of an association between onchocerciasis infection and epilepsy were carried out...
  91. ncbi The African Programme for Onchocerciasis Control (APOC)
    U Amazigo
    African Programme for Onchocerciasis Control, B P 549, Ouagadougou 01, Burkina Faso
    Ann Trop Med Parasitol 102:19-22. 2008
    The African Programme for Onchocerciasis Control (APOC) was launched in 1995, ultimately to eliminate human onchocerciasis from the African countries in which the disease was endemic...
  92. ncbi The effects of long-term community level treatment with ivermectin (Mectizan) on adult Onchocerca volvulus in Latin America
    Eddie W Cupp
    Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849 5413, USA
    Am J Trop Med Hyg 71:602-7. 2004
    ..volvulus populations in Mexico, Guatemala and Ecuador, indicating that semi-annual ivermectin treatment of >/=6 years has had a profound effect on survival and reproduction of this species...
  93. ncbi Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial density
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    J Infect Dis 185:1148-54. 2002
    ....
  94. ncbi The NGDO Co-ordination Group for Onchocerciasis Control
    D Haddad
    Helen Keller International, Regional Office for Africa, P O Box 29 898, Dakar Yoff, Senegal
    Ann Trop Med Parasitol 102:35-8. 2008
    ..development organizations (NGDO) have been actively involved in the mass distribution of this drug to control onchocerciasis. In 2006, the network of NGDO involved in onchocerciasis control assisted in the treatment of over 62 million ..
  95. ncbi Early human infection with Onchocerca volvulus is associated with an enhanced parasite-specific cellular immune response
    P J Cooper
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 183:1662-8. 2001
    ....
  96. ncbi Community-directed treatment of onchocerciasis with ivermectin in Takum, Nigeria
    O B Akogun
    Department of Parasites and Tropical Health, Federal University of Technology, Yola, Nigeria
    Trop Med Int Health 6:232-43. 2001
    ..Communities will only sustain a programme where the process of implementation fits well with local norms and where communities are free to alter PD procedures that are inconsistent with local customs...
  97. ncbi Studies on the dynamics of transmission of onchocerciasis in a Sudan-savanna area of North Cameroon V. What is a tolerable level of Annual Transmission Potential?
    A Renz
    Institute of Tropical Medicine, University of Tubingen, F R G
    Ann Trop Med Parasitol 81:263-74. 1987
    ..the sojourn times of the human population, were calculated at three of the villages, where the prevalence of onchocerciasis was 51, 61 and 89%...
  98. ncbi Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulus
    Norbert W Brattig
    Bernhard Nocht Institute for Tropical Medicine, D 20359 Hamburg, Germany
    Acta Trop 112:231-5. 2009
    ..was preferentially observed in the infiltrating macrophages in patients with a generalized hyporeactive onchocerciasis and less in patients with the hyperreactive form...
  99. ncbi Performance of predictors: evaluating sustainability in community-directed treatment projects of the African programme for onchocerciasis control
    Uche Amazigo
    World Health Organization, Ouagadougou, Burkina Faso
    Soc Sci Med 64:2070-82. 2007
    ..treatment with ivermectin (CDTI) at four implementation levels were evaluated in 41 African Programme for Onchocerciasis Control (APOC) projects, encompassing 492 communities in 10 countries...
  100. ncbi Problems and perspectives of managing an onchocerciasis control programme: a case study from Plateau state, Nigeria
    E S Miri
    Global 2000 River Blindness Program GRBP, Carter Center, Jos, Nigeria
    Ann Trop Med Parasitol 92:S121-8. 1998
    The onchocerciasis control programme in Plateau state (now Plateau and Nasarawa states), Nigeria, was one of the pioneering Mectizan-distribution projects in Nigeria...
  101. ncbi Development and evaluation of an antigen detection dipstick assay for the diagnosis of human onchocerciasis
    L S Ayong
    IMPM MINREST, Yaounde, Cameroon
    Trop Med Int Health 10:228-33. 2005
    To improve on the diagnosis of onchocerciasis, especially light infections, we developed and evaluated an oncho-dipstick test based on the detection of Onchocerca volvulus specific antigens in urine and tears...

Research Grants49

  1. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application.
  2. Embryogenesis and Larval Morphogenesis in Filariae
    Juliet Fuhrman; Fiscal Year: 2002
    ..Considerable morbidity results fr6m filarial infections such as lymphatic filariaisis (elephantiasis) and onchocerciasis (river blindness)...
  3. Compounds Targeting Nematode Secretion as Novel Anti-filarial Drugs
    Bethany Westlund; Fiscal Year: 2006
    ..novel chemical inhibitors of nematode secretion to treat parasitic infections like lymphatic filariasis and onchocerciasis. Using the model nematode Caenorhabditis elegans, we have identified 30 compounds that inhibited secretion ..
  4. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2013
    Human onchocerciasis is a serious neglected tropical disease caused by Onchocerca volvulus (Ov) and an important cause of blindness and chronic disability in the developing world...
  5. Environmental Triggers of Eating Seizures in Nodding Syndrome
    Peter S Spencer; Fiscal Year: 2013
    ..Nodding Syndrome is associated with skin infection with the nematode worm Onchocerca volvulus, the cause of onchocerciasis (River Blindness), but additional local environmental factors must participate because, in other parts of ..
  6. ETIOLOGY AND PATHOGENESIS OF PEMPHIGUS
    Luis A Diaz; Fiscal Year: 2013
    ..Moreover, the sera of patients with leishmaniasis, Chagas disease and onchocerciasis, where these insects are involved as carriers of parasites, possess anti-Dsg1 antibodies...
  7. Exploration of Chitinase Inhibitors for Human Health
    Kim D Janda; Fiscal Year: 2013
    ..One NTD for which there is a great need for a therapeutic evolution is onchocerciasis, or river blindness, a leading cause of blindness in the developing world...
  8. Trehalose-6-phosphate phosphatase: a target for anti-onchocerciasis therapeutics
    Debra Dunaway-Mariano; Fiscal Year: 2013
    ..This work will deliver the foundation for the development of a drug for the treatment of disease(s) inflicting the large segment of the world's population suffering from infection by parasitic nematodes. ..
  9. Humoral immune profiles at progressive time-points before and after cessation of
    Nidia Rizzo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Objective 1a, for work in Guatemala (Central Endemic Zone). Onchocerciasis is still a public health problem for several countries around the world...
  10. High Throughput Screen Development for Modulators of Heme Transporters
    Iqbal Hamza; Fiscal Year: 2011
    ..of helminth infections, Trypanosomiasis, intestinal nematodes, kinetoplastid diseases, lymphatic filariasis, onchocerciasis, and Leishmaniasis, as well as human genetic disorders of heme and iron metabolism...
  11. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2000
    b>Onchocerciasis, or river blindness, is major filarial disease and is the fifth most common cause of blindness in the world...
  12. BLACK FLY IMMUNITY TO ONCHOCERCA SPP
    EDDIE CUPP; Fiscal Year: 1993
    ..At least 663,000 persons are irreversibly blind as a result of chronic onchocerciasis and some 85,583,780 are at risk of infection...
  13. Mosquitocidal Avtive Clostridium Toxins
    Sarjeet Gill; Fiscal Year: 2007
    ..used with remarkable success for the control of Simulium vectors in West Africa, resulting in the reduction of onchocerciasis, a disease of critical importance in that region. Similarly, this bacterium together with B...
  14. MEASURING THE IMPACT OF ONCHOCERCIASIS CONTROL AND ELIMINATION PROBRA
    Sheba Gitta; Fiscal Year: 2013
    ..which will be implemented in three African countries (Uganda, DRC, and Ethiopia) which are endemic for onchocerciasis. The proposed project for Objective 1 will seek to measure the impact of onchocerciasis control and ..
  15. OXYGEN RADICAL-ENZYME SCAVENGING IN ONCHOCERCA
    Eric James; Fiscal Year: 1990
    b>Onchocerciasis affects 50 million people causing up to 1 million cases of blindness, several million cases of severe visual impairment and, in many more, considerable pathological changes in the skin...
  16. ONCHOCERCIASIS: IMMUNE-MEDIATED EYE DISEASE
    Bulbul Chakravarti; Fiscal Year: 1992
    ..b>Onchocerciasis is one of the leading causes of blindness in the world today...
  17. COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN
    James Jensen; Fiscal Year: 1993
    ..Four widespread and important human parasitoses will be addressed: malaria, schistosomiasis, onchocerciasis and leishmaniasis...
  18. CIRCULATING PARASITE ANTIGENS IN HUMAN FILARIASIS
    Gary Weil; Fiscal Year: 1991
    ..specific aim of this proposal is to develop and evaluate antigen diagnostic tests for brugian filariasis and onchocerciasis. Our expansion into the area of onchocerciasis is justified by a general recognition that improved diagnostic ..
  19. Ivermectin for Malaria Control
    BRIAN DAVID FOY; Fiscal Year: 2013
    ..Ivermectin is an oral drug, already given by mass administration to humans in the developing world for onchocerciasis control, and malaria vectors can ingest and be killed by this drug when they bite humans after these mass drug ..
  20. Spatial modeling of onchocerciasis foci in Africa by remote sensing
    Thomas R Unnasch; Fiscal Year: 2013
    b>Onchocerciasis is a debilitating disease caused by infection with the parasite Onchocerca volvulus...
  21. IDENTIFICATION--ONCHOCERCA VOLVULUS PROTECTIVE EPITOPES
    THOMAS UNNASCH; Fiscal Year: 1993
    ..volvulus infection. O. volvulus is the causative agent of onchocerciasis, which is one of the major causes of blindness in the world today...
  22. Functional Genomic Approach to Macrofilaricide Discovery
    James McCarter; Fiscal Year: 2005
    ..Blackfly transmission of the nematode Onchocercus volvulus leads to river blindness (onchocerciasis), while mosquito-transmitted filarial worms including Wucheria bancrofti and Brugia malayi are responsible for ..
  23. Endectocides for Malaria Control
    Brian Foy; Fiscal Year: 2009
    ..combined anti-helminthic and anti-ectoparasitic properties and are currently given to human populations for onchocerciasis and lymphatic filariasis control...
  24. RETINAL BINDING PROTEINS & AUTOIMMUNITY IN ONCHOCERCIASI
    Eric James; Fiscal Year: 1992
    b>Onchocerciasis affects approximately 20 million people. It remains a major cause of blindness n the world and continues to contribute to economic deprivation in much of its endemic range...
  25. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Onchocerciasis, or river blindness, is a major filarial disease and is the fifth most common cause of blindness in the world...
  26. A Helminth-Derived Immune Potentiator for Biodefense
    Sara Lustigman; Fiscal Year: 2006
    ..abstract_text> ..
  27. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 2005
    ....
  28. Newborn Antiseptic Washing and Neonatal Mortality-Nepal
    James Tielsch; Fiscal Year: 2005
    ..The umbilical cord infection trial will require only one year of recruitment to obtain adequate numbers to detect a 20% in infection rates in the treatment groups. ..
  29. ZINC SUPPLEMENTATION IMPACT ON CHILD MORTALITY--NEPAL
    James Tielsch; Fiscal Year: 2003
    ..The analysis will focus on comparison of rates of mortality and morbidity between treatment groups with additional analyses of subgroups to look for interaction by age, gender or baseline nutritional status. ..
  30. AMD AND RISK FACTORS IN A HISPANIC POPULATION
    Sheila West; Fiscal Year: 2003
    ..Such data will advance our understanding of the magnitude of AMD in this ethnic group, and the way in which risk factors relate to AMD in different populations. ..
  31. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  32. INTERVENTIONS FOR VISUAL LOSS IN NURSING HOME RESIDENTS
    Sheila West; Fiscal Year: 2002
    ..This trial will answer timely questions of the impact on the functional status of the most frail elderly of modest, potentially sustainable inputs into improving the appropriate utilization of eye care services. ..
  33. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
    ....
  34. BALTIMORE PEDIATRIC EYE SURVEY
    James Tielsch; Fiscal Year: 2007
    ..The analysis will focus on estimating the age and race-specific prevalence of ocular disorders in this group and on assessing the association of selected risk factors with the prevalence of these disorders. ..
  35. TRIAL OF ANTIBIOTICS TO REDUCE RECURRENT TRICHIASIS
    Sheila West; Fiscal Year: 2005
    ..abstract_text> ..
  36. TRAINING GRANT IN DERMATOLOGICAL RESEARCH
    Luis Diaz; Fiscal Year: 2006
    ..This competitive grant application requests funding to support the training at the UNC Dermatology Department of the next generation of dermatological investigators. ..
  37. Cataract: Health Disparity for Older African-Americans
    Sheila West; Fiscal Year: 2006
    ..These data will advance the goal of reducing health disparity in visual disability from cataract among older African Americans. ..
  38. Yearly Mass Treatment C. Trachomatis: When Can We Stop?
    Sheila West; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  39. Who drives safely? Visual/cognitive predictors in Elders
    Sheila West; Fiscal Year: 2008
    ..This study will provide critical data on the interactive role of vision, visual attention, and cognition in changing older persons driving behaviors, and the resulting effect on driver errors and risk of crashes. ..
  40. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
    ..abstract_text> ..
  41. Latino Eye Health: A Communication Strategy for Diabetes
    Sheila West; Fiscal Year: 2007
    ..Improvements in eye care seeking behaviors should help in avoiding visual loss from diabetic retinopathy and macula edema, the leading causes of visual loss in the working age Latino population. [unreadable] [unreadable]..
  42. CHARACTERIZATION OF DIFFERENT TYPES OF HUMAN MAST CELLS
    Lawrence Schwartz; Fiscal Year: 2009
    ..abstract_text> ..