Genomes and Genes
Summary: Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.
Publications314 found, 100 shown here
- Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: final results of a study in Mali and SenegalMamadou O Traoré
Direction nationale de la santé, Bamako, Mali
PLoS Negl Trop Dis 6:e1825. 2012Mass treatment with ivermectin controls onchocerciasis as a public health problem, but it was not known if it could also interrupt transmission and eliminate the parasite in endemic foci in Africa where vectors are highly efficient...
- Impact of long-term treatment of onchocerciasis with ivermectin in Kaduna State, Nigeria: first evidence of the potential for elimination in the operational area of the African Programme for Onchocerciasis ControlAfework Hailemariam Tekle
African Programme for Onchocerciasis Control, WHO APOC P, O, Box 01 B, P, 549, Ouagadougou 01, Burkina Faso
Parasit Vectors 5:28. 2012b>Onchocerciasis can be effectively controlled as a public health problem by annual mass drug administration of ivermectin, but it was not known if ivermectin treatment in the long term would be able to achieve elimination of onchocerciasis ..
- African Programme For Onchocerciasis Control 1995-2015: model-estimated health impact and costLuc E Coffeng
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
PLoS Negl Trop Dis 7:e2032. 2013b>Onchocerciasis causes a considerable disease burden in Africa, mainly through skin and eye disease. Since 1995, the African Programme for Onchocerciasis Control (APOC) has coordinated annual mass treatment with ivermectin in 16 countries...
- Lymphatic filariasis and onchocerciasisMark J Taylor
Liverpool School of Tropical Medicine, Liverpool, UK
Lancet 376:1175-85. 2010Lymphatic filariasis and onchocerciasis are parasitic helminth diseases that constitute a serious public health issue in tropical regions...
- Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and SenegalLamine Diawara
Ministère de Santé et de Prévention Médicale, Dakar, Senegal
PLoS Negl Trop Dis 3:e497. 2009Mass treatment with ivermectin is a proven strategy for controlling onchocerciasis as a public health problem, but it is not known if it can also interrupt transmission and eliminate the parasite in endemic foci in Africa where vectors ..
- Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infectionJ Gardon
Antenne ORSTOM auprès du Centre Pasteur, Yaounde, Cameroon
Lancet 350:18-22. 1997In 1995, the World Bank launched an African Programme for Onchocerciasis Control to eliminate Onchocerca volvulus disease from 19 African countries by means of community-based ivermectin treatment (CBIT)...
- Elimination of Onchocercia volvulus transmission in the Santa Rosa focus of GuatemalaKim A Lindblade
Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA
Am J Trop Med Hyg 77:334-41. 2007..We applied the 2001 World Health Organization (WHO) elimination criteria in the Santa Rosa focus of onchocerciasis transmission in Guatemala (10,923 persons at risk)...
- Can ivermectin mass treatments eliminate onchocerciasis in Africa?M Winnen
Department of Public Health, Erasmus University, Rotterdam, The Netherlands
Bull World Health Organ 80:384-91. 2002..To elucidate the conditions in which mass treatment with ivermectin reduces the transmission of Onchocerca volvulus sufficiently to eliminate infection from an African community...
- Onchocerciasis: the clinical and epidemiological burden of skin disease in AfricaM E Murdoch
Department of Biology, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BB, UK
Ann Trop Med Parasitol 96:283-96. 2002..skin disease throughout the African region and hence provide an objective basis for the rational planning of onchocerciasis control in the area...
- Onchocerciasis in the Americas: from arrival to (near) eliminationKen Gustavsen
Corporate Responsibility, Merck, 1 Merck Drive, WS2A 56, Whitehouse Station, New Jersey 08889, USA
Parasit Vectors 4:205. 2011b>Onchocerciasis (river blindness) is a blinding parasitic disease that threatens the health of approximately 120 million people worldwide...
- Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysisMaria Gloria Basanez
Department of Infectious Disease Epidemiology, Imperial College London, London, UK
Lancet Infect Dis 8:310-22. 2008The broad-spectrum antiparasitic drug ivermectin was licensed for use against onchocerciasis in 1987, yet the mechanisms by which it exerts a fast decrease and long-lasting suppression of Onchocerca volvulus microfilaridermia, and ..
- Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveysSebastien D S Pion
Unité Mixte de Recherche 145, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, Montpellier, France
PLoS Negl Trop Dis 3:e461. 2009We sought to evaluate the relationship between onchocerciasis prevalence and that of epilepsy using available data collected at community level.
- Elimination of human onchocerciasis: history of progress and current feasibility using ivermectin (Mectizan(®)) monotherapyE W Cupp
Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849, USA
Acta Trop 120:S100-8. 2011We review and analyze approaches over a 65 year period that have proven successful for onchocerciasis control in several different epidemiological settings...
- Control of onchocerciasis in Africa: threshold shifts, breakpoints and rules for eliminationHans P Duerr
Dept of Medical Biometry, University of Tuebingen, Westbahnhofstrasse 55, 72070 Tuebingen, Germany
Int J Parasitol 41:581-9. 2011Control of onchocerciasis in Africa is currently based on annual community-directed treatment with ivermectin (CDTI) which has been assumed to be not efficient enough to bring about elimination...
- Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulusMike Y Osei-Atweneboana
Institute of Parasitology, McGill University, Montreal, Canada
PLoS Negl Trop Dis 5:e998. 2011Ivermectin (IVM) has been used in Ghana for over two decades for onchocerciasis control. In recent years there have been reports of persistent microfilaridermias despite multiple treatments...
- Uncertainty surrounding projections of the long-term impact of ivermectin treatment on human onchocerciasisHugo C Turner
Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, Norfolk Place, London, United Kingdom
PLoS Negl Trop Dis 7:e2169. 2013..have indicated that annual (or biannual) ivermectin distribution may lead to local elimination of human onchocerciasis in certain African foci...
- Population biology of human onchocerciasisM G Basáñez
Wellcome Trust Centre for Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, UK
Philos Trans R Soc Lond B Biol Sci 354:809-26. 1999Human onchocerciasis (river blindness) is the filarial infection caused by Onchocerca volvulus and transmitted among people through the bites of the Simulium vector...
- Onchocerca-Simulium interactions and the population and evolutionary biology of Onchocerca volvulusMaria Gloria Basanez
Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
Adv Parasitol 68:263-313. 2009..we focus on Onchocerca-Simulium interactions with particular reference to the transmission dynamics of human onchocerciasis. A wide range of simuliid species may act as vectors of Onchocerca volvulus, each exerting their own influence ..
- Models for the population biology and control of human onchocerciasisM G Basáñez
Dept of Infectious Disease Epidemiology, Imperial College School of Medicine St Mary s Campus, Norfolk Place, W2 1PG, London, UK
Trends Parasitol 17:430-8. 2001..Here, we review the development of models concerning onchocerciasis and discuss the various approaches that have been used, presenting a deterministic framework with parameter ..
- Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasisFrancesca Tamarozzi
Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Parasit Vectors 5:53. 2012..superior to ivermectin and of great potential as an alternative approach for the treatment and control of onchocerciasis, particularly in areas of Loa loa co-endemicity...
- OnchocerciasisG Burnham
Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
Lancet 351:1341-6. 1998An estimated 17.7 million persons, most of them in Africa, are infected with the parasite Onchocerca volvulus. Onchocerciasis has caused blindness in 270,000 and left another 500,000 with severe visual impairment...
- Onchocerciasis: the pre-control association between prevalence of palpable nodules and skin microfilariaeLuc E Coffeng
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
PLoS Negl Trop Dis 7:e2168. 2013The prospect of eliminating onchocerciasis from Africa by mass treatment with ivermectin has been rejuvenated following recent successes in foci in Mali, Nigeria and Senegal...
- Density-dependent mortality of the human host in onchocerciasis: relationships between microfilarial load and excess mortalityMartin Walker
Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom
PLoS Negl Trop Dis 6:e1578. 2012..Determining the functional form of such relationship would contribute to quantify the population impact of mass microfilaricidal treatment...
- Diagnostic value of nodule palpation in onchocerciasisH P Duerr
Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
Trans R Soc Trop Med Hyg 102:148-54. 2008..is the major diagnostic tool for determining the prevalence of infection in areas of the African Programme for Onchocerciasis Control (APOC) and is recommended for identifying communities at risk and selecting them for mass drug ..
- Sampling strategies to detect anthelmintic resistance: the perspective of human onchocerciasisThomas S Churcher
Department of Infectious Disease Epidemiology, St Mary s Campus, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
Trends Parasitol 25:11-7. 2009....
- Elimination of onchocerciasis from Africa: possible?Charles D Mackenzie
Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA
Trends Parasitol 28:16-22. 2012Human onchocerciasis, a parasitic disease found in 28 African countries, six Latin American countries and Yemen, causes blindness and severe dermatological problems...
- Evidence for suppression of Onchocerca volvulus transmission in the Oaxaca focus in MexicoMario A Rodríguez-Pérez
Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Boulevard del Maestro Esquina Elías Piña, Col Narciso Mendoza, Reynosa, Tamaulipas, Mexico
Am J Trop Med Hyg 78:147-52. 2008..Taken together, these data suggest that transmission has been suppressed in the four communities...
- The Onchocerciasis Elimination Program for the Americas (OEPA)M Sauerbrey
Onchocerciasis Elimination Program for the Americas OEPA, 14 Calle 3 51 Zona 10, Edificio Murano Center, Oficina 1401, Guatemala City, Guatemala
Ann Trop Med Parasitol 102:25-9. 2008Human onchocerciasis (river blindness) occurs in 13 foci distributed among six countries in Latin America (Brazil, Colombia, Ecuador, Guatemala, Mexico and Venezuela), where about 500,000 people are considered at risk...
- A rapid mapping technique for the prevalence and distribution of onchocerciasis: a Cameroon case studyP Ngoumou
OCP, Ministry of Public Health, Yaounde, Cameroon
Ann Trop Med Parasitol 88:463-74. 1994A rapid and cheap method for mapping the endemicity levels of onchocerciasis in both forest and savanna areas, where the vectors are members of the Simulium damnosum complex, is described...
- The elimination of the vector Simulium neavei from the Itwara onchocerciasis focus in Uganda by ground larvicidingR Garms
Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
Acta Trop 111:203-10. 2009The Itwara focus of onchocerciasis covers an area of approximately 600 km(2) in western Uganda about 20 km north of Fort Portal. The vector is Simulium neavei, whose larvae and pupae live in a phoretic association on freshwater crabs...
- Progress towards the elimination of onchocerciasis as a public-health problem in Uganda: opportunities, challenges and the way forwardR Ndyomugyenyi
Vector Control Division, Ministry of Health, PO Box 1661, Kampala, Uganda
Ann Trop Med Parasitol 101:323-33. 2007The national onchocerciasis-control programme in Uganda successfully eliminated Simulium neavei s.s. from the Itwara focus in 1997, by monthly ground spraying with larvicidal temophos (Abate)...
- Mortality from epilepsy in an onchocerciasis-endemic area in West UgandaC Kaiser
Basic Health Services Kabarole and Bundibugyo Districts, Fort Portal, Uganda
Trans R Soc Trop Med Hyg 101:48-55. 2007..from epilepsy was investigated in a rural area of West Uganda where epilepsy is found to be closely linked to onchocerciasis. Thirty-three female and 28 male patients (age range 4-58 years, median 15 years) were identified in a ..
- Lymphatic filariasis in western Ethiopia with special emphasis on prevalence of Wuchereria bancrofti antigenaemia in and around onchocerciasis endemic areasWelelta Shiferaw
Department of Microbiology, Immunology and Parasitology DMIP Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
Trans R Soc Trop Med Hyg 106:117-27. 2012..6% respectively. Significantly higher (χ(2)=49.6; P<0.01) prevalence of antigenaemia was noted in known onchocerciasis endemic districts (4.7%) compared to non-onchocerciasis endemic districts (2.3%)...
- The African Programme for Onchocerciasis Control: impact on onchocercal skin diseaseG A Ozoh
Department of Dermatology, University of Nigeria Teaching Hospital, Ituku ozala, Nigeria
Trop Med Int Health 16:875-83. 2011To assess the long-term impact of the African Programme for Onchocerciasis Control on itching and onchocercal skin disease (OSD).
- Human ocular filariasis: further evidence on the zoonotic role of Onchocerca lupiDomenico Otranto
Dipartimento di Sanità Pubblica Veterinaria e Zootecnia, Universita degli Studi di Bari, Bari, Valenzano, Italy
Parasit Vectors 5:84. 2012..Other Onchocerca spp. have been sporadically reported as zoonotic agents. Cases of canine onchocerciasis caused by Onchocerca lupi are on the rise in the United States and Europe...
- Seventeen years of annual distribution of ivermectin has not interrupted onchocerciasis transmission in North Region, CameroonMoses N Katabarwa
The Carter Center, Atlanta, Georgia 30307, USA
Am J Trop Med Hyg 85:1041-9. 2011We studied onchocerciasis transmission and impact on ocular morbidity in three health districts in North Region, Cameroon, where annual mass ivermectin treatment has been provided for 12-17 years...
- Adverse systemic reactions to treatment of onchocerciasis with ivermectin at normal and high doses given annually or three-monthlyJoseph Kamgno
Laboratoire mixte IRD CPC d Epidémiologie et de Santé publique, Centre Pasteur du Cameroun, B P 1274, Yaounde, Cameroon
Trans R Soc Trop Med Hyg 98:496-504. 2004..and effects on transmission of large-scale 3-monthly treatments with standard doses of ivermectin for onchocerciasis control...
- Lack of active Onchocerca volvulus transmission in the northern Chiapas focus of MexicoMario A Rodríguez-Pérez
Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
Am J Trop Med Hyg 83:15-20. 2010The northern Chiapas onchocerciasis focus has undergone 11 years of ivermectin mass treatment...
- Assessment and monitoring of onchocerciasis in Latin AmericaMario A Rodríguez-Pérez
Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Ciudad Reynosa, Tamaulipas, Mexico
Adv Parasitol 77:175-226. 2011b>Onchocerciasis has historically been one of the leading causes of infectious blindness worldwide. It is endemic to tropical regions both in Africa and Latin America and in the Yemen...
- Does onchocerciasis transmission take place in hypoendemic areas? a study from the North Region of CameroonMoses N Katabarwa
The Carter Center, Emory University, Atlanta, GA, USA
Trop Med Int Health 15:645-52. 2010Community-directed treatment with ivermectin (CDTI) for onchocerciasis control is targeted to meso and hyperendemic areas in Africa. Below the threshold, communities are considered hypoendemic and, mass treatment is not recommended...
- Factors affecting the attrition of community-directed distributors of ivermectin, in an onchocerciasis-control programme in the Imo and Abia states of south-eastern NigeriaE C Emukah
National Office, Global 2000 Program, The Carter Center, Jos, Nigeria
Ann Trop Med Parasitol 102:45-51. 2008In areas of Nigeria where onchocerciasis is endemic, community-directed distributors (CDD) distribute ivermectin annually, as part of the effort to control the disease...
- The impact of ivermectin treatment alone and when in parallel with Simulium neavei elimination on onchocerciasis in UgandaRichard Ndyomugyenyi
National Onchocerciasis Control Programme, Vector Control Division, Kampala, Uganda
Trop Med Int Health 9:882-6. 2004..2002 in Kigoyera parish in Kyenjojo district, where ivermectin treatment had been the strategy to control onchocerciasis since 1991 and was later supplemented with Simulium neavei control in 1995 and subsequent elimination; and in ..
- The relationships between the burden of adult parasites, host age and the microfilarial density in human onchocerciasisH P Duerr
Department of Medical Biometry, University of Tubingen, Westbahnhofstr 55, 72070 Tübingen, Germany
Int J Parasitol 34:463-73. 2004..The data of 169 patients in Burkina Faso and 182 patients in Liberia represent savannah and forest onchocerciasis in West Africa, respectively...
- Epidemiology and control of onchocerciasis: the threshold biting rate of savannah onchocerciasis in AfricaHans P Duerr
Department of Medical Biometry, University of Tuebingen, Westbahnhofstr 55, 72070 Tuebingen, Germany
Int J Parasitol 40:641-50. 2010Control of onchocerciasis currently focuses on community-directed treatment with the microfilaricide ivermectin which effectively kills Onchocerca volvulus microfilariae in the human host...
- Three probable cases of Loa loa encephalopathy following ivermectin treatment for onchocerciasisM Boussinesq
Antenne de l Institut Francais de Recherche Scientifique pour le Developpement en Cooperation ORSTOM aupres du Centre Pasteur du Cameroun, Yaounde, Cameroon
Am J Trop Med Hyg 58:461-9. 1998..Before launching mass ivermectin distribution programs to control onchocerciasis in central Africa, communities in which the intensity of concomitant L...
- Repositioning of an existing drug for the neglected tropical disease OnchocerciasisChristian Gloeckner
Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 107:3424-9. 2010b>Onchocerciasis, or river blindness, is a neglected tropical disease caused by the filarial nematode Onchocerca volvulus that affects more than 37 million people, mainly in third world countries...
- Polymerase chain reaction monitoring of transmission of Onchocerca volvulus in two endemic states in MexicoMario A Rodríguez-Pérez
Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
Am J Trop Med Hyg 70:38-45. 2004..These findings suggest that while substantial progress towards elimination has been made in Mexico, it may be necessary to modify ivermectin distribution strategies to eliminate transmission in areas where transmission persists...
- Onchocercosis: a newly recognized disease in dogsTamás Sréter
Laboratories for Parasites, Fish, Bee and Wildlife Diseases, Veterinary Diagnostic Directorate, Central Agricultural Office, H 1149, Budapest, Hungary
Vet Parasitol 151:1-13. 2008..As infections in dogs may provide a practical experimental system, further studies should be encouraged to try to establish experimental Onchocerca infections in dogs...
- Ivermectin: 25 years and still going strongS Omura
The Kitasato Institute, Tokyo, Japan
Int J Antimicrob Agents 31:91-8. 2008....
- Interruption of transmission of Onchocerca volvulus in the Oaxaca focus, MexicoMario A Rodríguez-Pérez
Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, Tamaulipas, Mexico
Am J Trop Med Hyg 83:21-7. 2010All endemic communities of the Oaxaca focus of onchocerciasis in southern Mexico have been treated annually or semi-annually with ivermectin since 1994. In-depth epidemiologic assessments were performed in communities during 2007 and 2008...
- Required duration of combined annual ivermectin treatment and vector control in the Onchocerciasis Control Programme in west AfricaA P Plaisier
Department of Public Health, Faculty of Medicine, Erasmus University Rotterdam, Netherlands
Bull World Health Organ 75:237-45. 1997In the extension areas of the Onchocerciasis Control Programme in West Africa, aerial larviciding is supplemented with annual ivermectin treatment, mainly to achieve better control of morbidity...
- A rapid-format antibody card test for diagnosis of onchocerciasisG J Weil
Infectious Diseases Division, Barnes Jewish Hospital, St Louis, MO 63110, USA
J Infect Dis 182:1796-9. 2000Improved methods are needed for field diagnosis of onchocerciasis, to support efforts aimed at elimination of the disease...
- P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulusCatherine Bourguinat
Institute of Parasitology, McGill University, 21 111 Lakeshore Road, Sainte Anne de Bellevue, Quebec, Canada H9X3V9
Mol Biochem Parasitol 158:101-11. 2008Ivermectin (IVM) is the only safe drug for mass-treatment of onchocerciasis. IVM resistance has been reported in gastrointestinal nematode parasites of animals...
- Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteriaN W Brattig
Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany
Microbes Infect 6:113-28. 2004Onchocerca volvulus is a tissue-invasive parasitic nematode causing skin and eye pathology in human onchocerciasis. The filariae habour abundant intracellular Wolbachia bacteria, now recognised as obligatory symbionts, and therefore ..
- Blackfly vectors of zoonotic onchocerciasis in JapanH Takaoka
Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
Med Vet Entomol 26:372-8. 2012..Bain & Takaoka (Spirurida: Onchocercidae), a parasite of wild boar implicated in the aetiology of zoonotic onchocerciasis in Japan, and six other zoonotic Onchocerca species of this country are reviewed...
- Community-directed treatment with ivermectin in two Nigerian communities: an analysis of first year start-up processes, costs and consequencesObinna Onwujekwe
Health Policy Research Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, P M B 01129, Enugu, Nigeria
Health Policy 62:31-51. 2002..the start-up processes, costs and consequences of community-directed treatment with ivermectin (CDTI) in two onchocerciasis endemic rural towns of Southeast Nigeria; namely Achi and Nike...
- Integrated rapid mapping of onchocerciasis and loiasis in the Democratic Republic of Congo: impact on control strategiesAfework Hailemariam Tekle
African Program for Onchocerciasis Control, Epidemiology and Vector Elimination, Rue Naba Zombre 1538, Sector 9 Door Number 1473, Ougadougou, Burkina Faso
Acta Trop 120:S81-90. 2011b>Onchocerciasis can be effectively controlled by annual mass treatment with ivermectin in endemic communities...
- The Onchocerciasis Control Programme in West Africa (OCP)B Boatin
UNICEF UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases, 20 Avenue Appia, CH 1211 Geneva 27, Switzerland
Ann Trop Med Parasitol 102:13-7. 2008The Onchocerciasis Control Programme in West Africa (OCP) started operations in 1975...
- Field applicability of a rapid-format anti-Ov-16 antibody test for the assessment of onchocerciasis control measures in regions of endemicityEttie M Lipner
Office of Global Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 194:216-21. 2006..A previously developed, specific, rapid-format immunochromatographic card test that detects immunoglobulin G4 to the recombinant Onchocerca volvulus antigen Ov-16 was modified to detect antibodies in whole blood...
- The cost of annual versus biannual community-directed treatment of onchocerciasis with ivermectin: Ghana as a case studyHugo C Turner
Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine St Mary s Campus, Imperial College London, Norfolk Place, London, United Kingdom
PLoS Negl Trop Dis 7:e2452. 2013..biannual (twice yearly) mass community-directed treatment with ivermectin (CDTI) might improve the chances of onchocerciasis elimination in some African foci...
- Association between onchocerciasis and epilepsy in the Itwara hyperendemic focus, West Uganda: controlling for time and intensity of exposureChristoph Kaiser
Basic Health Services, Kabarole and Bundibugyo Districts, Fort Portal, Uganda
Am J Trop Med Hyg 85:225-8. 2011In 38 pairs of epilepsy patients and controls matched for time and intensity of exposure to transmission of onchocerciasis, the presence of microfilariae in the skin of epilepsy patients was found insignificantly elevated compared with ..
- [Endemicity and clinical manifestations of onchocerciasis in the provinces of Cibitoke and Bubanza (Burundi)]E D Newell
national de lutte contre l onchocercose, Bujumbura, Burundi
Bull Soc Pathol Exot 90:353-7. 1997The prevalence and intensity of onchocerciasis in the endemic region of the provinces of Cibitoke and Bubanza (Burundi) have been determined through the examination of a sample of the population of 33 "collines" (administrative ..
- The elimination of the onchocerciasis vector from the island of Bioko as a result of larviciding by the WHO African Programme for Onchocerciasis ControlS Traore
African Programme for Onchocerciasis Control WHO APOC, 01 BP 549 Ouagadougou 01, Burkina Faso
Acta Trop 111:211-8. 2009..of Bioko is part of the Republic of Equatorial Guinea and is the only island in the World to have endemic onchocerciasis. The disease is hyperendemic and shows a forest-type epidemiology with low levels of blindness and high levels ..
- Individual host factors associated with Onchocerca volvulus microfilarial densities 15, 80 and 180 days after a first dose of ivermectinSebastien D S Pion
Unité Mixte de Recherche 145, Institut de Recherche pour le Développement and University of Montpellier 1, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
Acta Trop 120:S91-9. 2011..Data from two separate studies conducted in Cameroon on onchocerciasis patients treated for the first time with ivermectin were analyzed to identify host factors associated with ..
- Characteristics of persons who complied with and failed to comply with annual ivermectin treatmentWilliam R Brieger
Department of International Health, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Trop Med Int Health 17:920-30. 2012To assess individual compliance with annual ivermectin treatment in onchocerciasis-endemic villages.
- Zoonotic Onchocerca lupi infection in a 22-month-old child in Arizona: first report in the United States and a review of the literatureMark L Eberhard
Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Trop Med Hyg 88:601-5. 2013..A great deal more needs to be learned, including full host range and geographic distribution, before we fully understand O. lupi infections in animals and man...
- Cattle protected from onchocerciasis by ivermectin are highly susceptible to infection after drug withdrawalL M Njongmeta
Veterinary Parasitology, Liverpool School of Tropical Medicine and Faculty of Veterinary Science, University of Liverpool, Pembroke Place, Liverpool L3 5QA, UK
Int J Parasitol 34:1069-74. 2004Ivermectin administration is now the major tool in the control of human onchocerciasis (caused by Onchocerca volvulus) based on its suppression of microfilariae and hence the prevention of disease...
- Entomological evaluation by pool screen polymerase chain reaction of Onchocerca volvulus transmission in Ecuador following mass Mectizan distributionAngel G Guevara
Laboratory of Clinical Investigation, Community Services Vozandes, Quito, Ecuador
Am J Trop Med Hyg 68:222-7. 2003..by pool screen polymerase chain reaction (PCR) amplification in the three river basins in Ecuador endemic for onchocerciasis. Mass distribution of ivermectin (Mectizan) resulted in dramatic declines in the prevalence of infected and ..
- Diagnostics in onchocerciasis: future challengesB A Boatin
World Health Organization Onchocerciasis Control Programme in West Africa, Ouagadougou, Burkina Faso
Ann Trop Med Parasitol 92:S41-5. 1998..Given all these factors, the greater challenge in the area of diagnostics for onchocerciasis is to develop a less invasive, adequately sensitive, and equally specific diagnostic test, either to replace ..
- [Endemic disease and clinical manifestations of onchocerciasis in the province of Rutana (Burundi)]E D Newell
Programme national de lutte contre l onchocercose, Programme de lutte contre les maladies transmissibles et carentielles L M T C, Bujumbura, Burundi
Bull Soc Pathol Exot 90:107-10. 1997..of Rutana (Burundi) a sample of the population was examined to determine the prevalence and intensity of onchocerciasis in this endemic region. In all, the area is hypoendemic with 7.9% of the population infected...
- The burden of onchocerciasis in UgandaR Ndyomugyenyi
National Onchocerciasis Control Programme, Ministry of Health, Kampala, Uganda
Ann Trop Med Parasitol 92:S133-7. 1998b>Onchocerciasis is far more prevalent and far more of a public-health and socio-economic problem in Uganda than it was thought to be a decade ago...
- Operational lessons from 20 years of the Mectizan Donation Program for the control of onchocerciasisB Thylefors
Mectizan Donation Program, Decatur, GA 30030, USA
Trop Med Int Health 13:689-96. 2008The donation of ivermectin (Mectizan, Merck & Co., Inc.) to control onchocerciasis (river blindness) was established in 1987 and has since gradually expanded to provide for >570 million treatments cumulatively over the past 20 ..
- Impact of parental onchocerciasis and intensity of transmission on development and persistence of Onchocerca volvulus infection in offspring: an 18 year follow-up studyA K Kirch
Institute for Tropical Medicine, University of Tubingen, Germany
Parasitology 127:327-35. 2003..Longitudinal follow up of children showed that during vector control activities by the Onchocerciasis Control Programme (OCP) and in low-level transmission areas, infection persisted at higher levels in children ..
- Immunisation with a multivalent, subunit vaccine reduces patent infection in a natural bovine model of onchocerciasis during intense field exposureBenjamin L Makepeace
Veterinary Parasitology Group, Liverpool School of Tropical Medicine and Faculty of Veterinary Science, University of Liverpool, Liverpool, United Kingdom
PLoS Negl Trop Dis 3:e544. 2009Human onchocerciasis, caused by the filarial nematode Onchocerca volvulus, is controlled almost exclusively by the drug ivermectin, which prevents pathology by targeting the microfilariae...
- Eosinophils, eosinophil cationic protein and eosinophil-derived neurotoxin in serum and urine of patients with onchocerciasis coinfected with intestinal nematodes and in urinary schistosomiasisF W Tischendorf
Department of Clinical Chemistry, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Acta Trop 72:157-73. 1999..The highest serum ECP and serum and urinary EDN/EPX levels were observed in the hyperreactive form of onchocerciasis (sowda). Onchocerciasis patients and O...
- Controlling onchocerciasis by community-directed, ivermectin-treatment programmes in Uganda: why do some communities succeed and others fail?N M Katabarwa
Global 2000 River Blindness Program, Carter Center, Kampala, Uganda
Ann Trop Med Parasitol 94:343-52. 2000In Uganda, human onchocerciasis is controlled by annual, mass, community-directed, ivermectin-treatment programmes (CDITP) in all endemic communities where the prevalence of the disease is > or = 30%...
- Simultaneous administration of praziquantel, ivermectin and albendazole, in a community in rural northern Ghana endemic for schistosomiasis, onchocerciasis and lymphatic filariasisFrancis Anto
Navrongo Health Research Centre, Navrongo, Ghana
Trop Med Int Health 16:1112-9. 2011....
- Resistance and susceptibility in human onchocerciasis--beyond Th1 vs. Th2Achim Hoerauf
Bernhard Nocht Institute of Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany
Trends Parasitol 18:25-31. 2002As research progress has led to programs for the elimination of onchocerciasis as a public health problem, research must now be intensified to protect elimination efforts...
- Whither onchocerciasis control in Africa?D R Hopkins
Am J Trop Med Hyg 72:1-2. 2005
- The role of Onchocerca volvulus in the development of epilepsy in a rural area of TanzaniaRebekka König
Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Parasitology 137:1559-68. 2010Several reports indicate high prevalences of both onchocerciasis and epilepsy in some regions of Africa. This raises the question of whether these diseases are associated...
- Reduced genetic variation of an Onchocerca volvulus ABC transporter gene following treatment with ivermectinB F Ardelli
Institute of Parasitology, Macdonald Campus, McGill University, 21 111 Lakeshore Road, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
Trans R Soc Trop Med Hyg 101:1223-32. 2007..Mass treatment with IVM is an integral component of the onchocerciasis control programmes...
- Compliance with eight years of annual ivermectin treatment of onchocerciasis in Cameroon and NigeriaWilliam R Brieger
Department of International Health, The Johns Hopkins UniversityBloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21014, USA
Parasit Vectors 4:152. 2011As the African Programme for Onchocerciasis Control (APOC) matured into its 10th year of ensuring community involvement in mass annual treatment of onchocerciasis with ivermectin, there was recognition of a need to study not only annual ..
- Adverse reactions following annual ivermectin treatment of onchocerciasis in NigeriaWellington A Oyibo
Department of Microbiology, Immunology and Parasitology, Faculty of Medicine, Addis Abbaba University, Addis Ababa, Ethiopia
Int J Infect Dis 7:156-9. 2003..As communities are empowered to distribute ivermectin, monitoring of adverse reactions by health care professionals is important in achieving the onchocerciasis control objectives through mass ivermectin therapy.
- Traditional kinship system enhanced classic community-directed treatment with ivermectin (CDTI) for onchocerciasis control in UgandaMoses N Katabarwa
The Emory University Carter Center, 1149 Ponce de Leon Avenue, Atlanta GA 30306, USA
Trans R Soc Trop Med Hyg 104:265-72. 2010The challenges of community-directed treatment with ivermectin (CDTI) for onchocerciasis control in Africa have been: maintaining a desired treatment coverage, demand for monetary incentives, high attrition of community distributors and ..
- The effect of 5 years of annual treatment with ivermectin (Mectizan) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African RepublicM H Kennedy
Task Force for Child Survival, Mectizan Donation Program, 750 Commerce Drive, Decatur, GA 30030, USA
Ann Trop Med Parasitol 96:297-307. 2002To assess the impact of 5 years of annual community treatment with ivermectin (Mectizan) on the prevalence of onchocerciasis and onchocerciasis-associated morbidity, data collected, before and after such treatment, in the village of Gami, ..
- OnchodermatitisMichele E Murdoch
Watford General Hospital, Watford, UK
Curr Opin Infect Dis 23:124-31. 2010..This review is timely because awareness of the burden of disease from onchodermatitis has increased significantly over recent years. Recent progress in the field is reviewed with emphasis on publications within the past 2 years...
- Dracunculiasis, onchocerciasis, schistosomiasis, and trachomaDonald R Hopkins
Health Programs, The Carter Center, 453 Freedom Pkwy, Atlanta, GA 30307, USA
Ann N Y Acad Sci 1136:45-52. 2008The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a contributor to the ..
- Large-scale entomologic assessment of Onchocerca volvulus transmission by poolscreen PCR in MexicoMario A Rodríguez-Pérez
Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Cd Reynosa, Tamaulipas, Mexico
Am J Trop Med Hyg 74:1026-33. 2006..These data suggest that O. volvulus transmission in Mexico has been suppressed or brought to a level that may be insufficient to sustain the parasite population...
- Successful interruption of transmission of Onchocerca volvulus in the Escuintla-Guatemala focus, GuatemalaRodrigo J Gonzalez
Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala
PLoS Negl Trop Dis 3:e404. 2009Elimination of onchocerciasis (river blindness) through mass administration of ivermectin in the six countries in Latin America where it is endemic is considered feasible due to the relatively small size and geographic isolation of ..
- Review of epidemiological studies searching for a relationship between onchocerciasis and epilepsyM Druet-Cabanac
Institute of Neuroepidemiology and Tropical Neurology EA 3174, Limoges, France
Neuroepidemiology 23:144-9. 2004A review and a meta-analysis of the available epidemiological literature for evidence of an association between onchocerciasis infection and epilepsy were carried out...
- The African Programme for Onchocerciasis Control (APOC)U Amazigo
African Programme for Onchocerciasis Control, B P 549, Ouagadougou 01, Burkina Faso
Ann Trop Med Parasitol 102:19-22. 2008The African Programme for Onchocerciasis Control (APOC) was launched in 1995, ultimately to eliminate human onchocerciasis from the African countries in which the disease was endemic...
- The effects of long-term community level treatment with ivermectin (Mectizan) on adult Onchocerca volvulus in Latin AmericaEddie W Cupp
Department of Entomology and Plant Pathology, Auburn University, Auburn, AL 36849 5413, USA
Am J Trop Med Hyg 71:602-7. 2004..volvulus populations in Mexico, Guatemala and Ecuador, indicating that semi-annual ivermectin treatment of >/=6 years has had a profound effect on survival and reproduction of this species...
- Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial densityNorbert W Brattig
Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
J Infect Dis 185:1148-54. 2002....
- The NGDO Co-ordination Group for Onchocerciasis ControlD Haddad
Helen Keller International, Regional Office for Africa, P O Box 29 898, Dakar Yoff, Senegal
Ann Trop Med Parasitol 102:35-8. 2008..development organizations (NGDO) have been actively involved in the mass distribution of this drug to control onchocerciasis. In 2006, the network of NGDO involved in onchocerciasis control assisted in the treatment of over 62 million ..
- Early human infection with Onchocerca volvulus is associated with an enhanced parasite-specific cellular immune responseP J Cooper
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 183:1662-8. 2001....
- Community-directed treatment of onchocerciasis with ivermectin in Takum, NigeriaO B Akogun
Department of Parasites and Tropical Health, Federal University of Technology, Yola, Nigeria
Trop Med Int Health 6:232-43. 2001..Communities will only sustain a programme where the process of implementation fits well with local norms and where communities are free to alter PD procedures that are inconsistent with local customs...
- Studies on the dynamics of transmission of onchocerciasis in a Sudan-savanna area of North Cameroon V. What is a tolerable level of Annual Transmission Potential?A Renz
Institute of Tropical Medicine, University of Tubingen, F R G
Ann Trop Med Parasitol 81:263-74. 1987..the sojourn times of the human population, were calculated at three of the villages, where the prevalence of onchocerciasis was 51, 61 and 89%...
- Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulusNorbert W Brattig
Bernhard Nocht Institute for Tropical Medicine, D 20359 Hamburg, Germany
Acta Trop 112:231-5. 2009..was preferentially observed in the infiltrating macrophages in patients with a generalized hyporeactive onchocerciasis and less in patients with the hyperreactive form...
- Performance of predictors: evaluating sustainability in community-directed treatment projects of the African programme for onchocerciasis controlUche Amazigo
World Health Organization, Ouagadougou, Burkina Faso
Soc Sci Med 64:2070-82. 2007..treatment with ivermectin (CDTI) at four implementation levels were evaluated in 41 African Programme for Onchocerciasis Control (APOC) projects, encompassing 492 communities in 10 countries...
- Problems and perspectives of managing an onchocerciasis control programme: a case study from Plateau state, NigeriaE S Miri
Global 2000 River Blindness Program GRBP, Carter Center, Jos, Nigeria
Ann Trop Med Parasitol 92:S121-8. 1998The onchocerciasis control programme in Plateau state (now Plateau and Nasarawa states), Nigeria, was one of the pioneering Mectizan-distribution projects in Nigeria...
- Development and evaluation of an antigen detection dipstick assay for the diagnosis of human onchocerciasisL S Ayong
IMPM MINREST, Yaounde, Cameroon
Trop Med Int Health 10:228-33. 2005To improve on the diagnosis of onchocerciasis, especially light infections, we developed and evaluated an oncho-dipstick test based on the detection of Onchocerca volvulus specific antigens in urine and tears...
- PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAESara Lustigman; Fiscal Year: 2001..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application.
- Embryogenesis and Larval Morphogenesis in FilariaeJuliet Fuhrman; Fiscal Year: 2002..Considerable morbidity results fr6m filarial infections such as lymphatic filariaisis (elephantiasis) and onchocerciasis (river blindness)...
- Compounds Targeting Nematode Secretion as Novel Anti-filarial DrugsBethany Westlund; Fiscal Year: 2006..novel chemical inhibitors of nematode secretion to treat parasitic infections like lymphatic filariasis and onchocerciasis. Using the model nematode Caenorhabditis elegans, we have identified 30 compounds that inhibited secretion ..
- The development of a recombinant vaccine against human onchocerciasisSara Lustigman; Fiscal Year: 2013Human onchocerciasis is a serious neglected tropical disease caused by Onchocerca volvulus (Ov) and an important cause of blindness and chronic disability in the developing world...
- Environmental Triggers of Eating Seizures in Nodding SyndromePeter S Spencer; Fiscal Year: 2013..Nodding Syndrome is associated with skin infection with the nematode worm Onchocerca volvulus, the cause of onchocerciasis (River Blindness), but additional local environmental factors must participate because, in other parts of ..
- ETIOLOGY AND PATHOGENESIS OF PEMPHIGUSLuis A Diaz; Fiscal Year: 2013..Moreover, the sera of patients with leishmaniasis, Chagas disease and onchocerciasis, where these insects are involved as carriers of parasites, possess anti-Dsg1 antibodies...
- Exploration of Chitinase Inhibitors for Human HealthKim D Janda; Fiscal Year: 2013..One NTD for which there is a great need for a therapeutic evolution is onchocerciasis, or river blindness, a leading cause of blindness in the developing world...
- Trehalose-6-phosphate phosphatase: a target for anti-onchocerciasis therapeuticsDebra Dunaway-Mariano; Fiscal Year: 2013..This work will deliver the foundation for the development of a drug for the treatment of disease(s) inflicting the large segment of the world's population suffering from infection by parasitic nematodes. ..
- Humoral immune profiles at progressive time-points before and after cessation ofNidia Rizzo; Fiscal Year: 2013DESCRIPTION (provided by applicant): Objective 1a, for work in Guatemala (Central Endemic Zone). Onchocerciasis is still a public health problem for several countries around the world...
- High Throughput Screen Development for Modulators of Heme TransportersIqbal Hamza; Fiscal Year: 2011..of helminth infections, Trypanosomiasis, intestinal nematodes, kinetoplastid diseases, lymphatic filariasis, onchocerciasis, and Leishmaniasis, as well as human genetic disorders of heme and iron metabolism...
- CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENTSara Lustigman; Fiscal Year: 2000b>Onchocerciasis, or river blindness, is major filarial disease and is the fifth most common cause of blindness in the world...
- BLACK FLY IMMUNITY TO ONCHOCERCA SPPEDDIE CUPP; Fiscal Year: 1993..At least 663,000 persons are irreversibly blind as a result of chronic onchocerciasis and some 85,583,780 are at risk of infection...
- Mosquitocidal Avtive Clostridium ToxinsSarjeet Gill; Fiscal Year: 2007..used with remarkable success for the control of Simulium vectors in West Africa, resulting in the reduction of onchocerciasis, a disease of critical importance in that region. Similarly, this bacterium together with B...
- MEASURING THE IMPACT OF ONCHOCERCIASIS CONTROL AND ELIMINATION PROBRASheba Gitta; Fiscal Year: 2013..which will be implemented in three African countries (Uganda, DRC, and Ethiopia) which are endemic for onchocerciasis. The proposed project for Objective 1 will seek to measure the impact of onchocerciasis control and ..
- OXYGEN RADICAL-ENZYME SCAVENGING IN ONCHOCERCAEric James; Fiscal Year: 1990b>Onchocerciasis affects 50 million people causing up to 1 million cases of blindness, several million cases of severe visual impairment and, in many more, considerable pathological changes in the skin...
- ONCHOCERCIASIS: IMMUNE-MEDIATED EYE DISEASEBulbul Chakravarti; Fiscal Year: 1992..b>Onchocerciasis is one of the leading causes of blindness in the world today...
- COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDANJames Jensen; Fiscal Year: 1993..Four widespread and important human parasitoses will be addressed: malaria, schistosomiasis, onchocerciasis and leishmaniasis...
- CIRCULATING PARASITE ANTIGENS IN HUMAN FILARIASISGary Weil; Fiscal Year: 1991..specific aim of this proposal is to develop and evaluate antigen diagnostic tests for brugian filariasis and onchocerciasis. Our expansion into the area of onchocerciasis is justified by a general recognition that improved diagnostic ..
- Ivermectin for Malaria ControlBRIAN DAVID FOY; Fiscal Year: 2013..Ivermectin is an oral drug, already given by mass administration to humans in the developing world for onchocerciasis control, and malaria vectors can ingest and be killed by this drug when they bite humans after these mass drug ..
- Spatial modeling of onchocerciasis foci in Africa by remote sensingThomas R Unnasch; Fiscal Year: 2013b>Onchocerciasis is a debilitating disease caused by infection with the parasite Onchocerca volvulus...
- IDENTIFICATION--ONCHOCERCA VOLVULUS PROTECTIVE EPITOPESTHOMAS UNNASCH; Fiscal Year: 1993..volvulus infection. O. volvulus is the causative agent of onchocerciasis, which is one of the major causes of blindness in the world today...
- Functional Genomic Approach to Macrofilaricide DiscoveryJames McCarter; Fiscal Year: 2005..Blackfly transmission of the nematode Onchocercus volvulus leads to river blindness (onchocerciasis), while mosquito-transmitted filarial worms including Wucheria bancrofti and Brugia malayi are responsible for ..
- Endectocides for Malaria ControlBrian Foy; Fiscal Year: 2009..combined anti-helminthic and anti-ectoparasitic properties and are currently given to human populations for onchocerciasis and lymphatic filariasis control...
- RETINAL BINDING PROTEINS & AUTOIMMUNITY IN ONCHOCERCIASIEric James; Fiscal Year: 1992b>Onchocerciasis affects approximately 20 million people. It remains a major cause of blindness n the world and continues to contribute to economic deprivation in much of its endemic range...
- CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENTSara Lustigman; Fiscal Year: 2005DESCRIPTION (provided by the applicant): Onchocerciasis, or river blindness, is a major filarial disease and is the fifth most common cause of blindness in the world...
- A Helminth-Derived Immune Potentiator for BiodefenseSara Lustigman; Fiscal Year: 2006..abstract_text> ..
- BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMESLawrence Schwartz; Fiscal Year: 2005....
- Newborn Antiseptic Washing and Neonatal Mortality-NepalJames Tielsch; Fiscal Year: 2005..The umbilical cord infection trial will require only one year of recruitment to obtain adequate numbers to detect a 20% in infection rates in the treatment groups. ..
- ZINC SUPPLEMENTATION IMPACT ON CHILD MORTALITY--NEPALJames Tielsch; Fiscal Year: 2003..The analysis will focus on comparison of rates of mortality and morbidity between treatment groups with additional analyses of subgroups to look for interaction by age, gender or baseline nutritional status. ..
- AMD AND RISK FACTORS IN A HISPANIC POPULATIONSheila West; Fiscal Year: 2003..Such data will advance our understanding of the magnitude of AMD in this ethnic group, and the way in which risk factors relate to AMD in different populations. ..
- HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENTPeter Hotez; Fiscal Year: 2002..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
- INTERVENTIONS FOR VISUAL LOSS IN NURSING HOME RESIDENTSSheila West; Fiscal Year: 2002..This trial will answer timely questions of the impact on the functional status of the most frail elderly of modest, potentially sustainable inputs into improving the appropriate utilization of eye care services. ..
- EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASELawrence Schwartz; Fiscal Year: 2001....
- BALTIMORE PEDIATRIC EYE SURVEYJames Tielsch; Fiscal Year: 2007..The analysis will focus on estimating the age and race-specific prevalence of ocular disorders in this group and on assessing the association of selected risk factors with the prevalence of these disorders. ..
- TRIAL OF ANTIBIOTICS TO REDUCE RECURRENT TRICHIASISSheila West; Fiscal Year: 2005..abstract_text> ..
- TRAINING GRANT IN DERMATOLOGICAL RESEARCHLuis Diaz; Fiscal Year: 2006..This competitive grant application requests funding to support the training at the UNC Dermatology Department of the next generation of dermatological investigators. ..
- Cataract: Health Disparity for Older African-AmericansSheila West; Fiscal Year: 2006..These data will advance the goal of reducing health disparity in visual disability from cataract among older African Americans. ..
- Yearly Mass Treatment C. Trachomatis: When Can We Stop?Sheila West; Fiscal Year: 2008..unreadable] [unreadable]..
- Who drives safely? Visual/cognitive predictors in EldersSheila West; Fiscal Year: 2008..This study will provide critical data on the interactive role of vision, visual attention, and cognition in changing older persons driving behaviors, and the resulting effect on driver errors and risk of crashes. ..
- Innate immune responses in lymphatic filariasisAMY HISE; Fiscal Year: 2007..abstract_text> ..
- Latino Eye Health: A Communication Strategy for DiabetesSheila West; Fiscal Year: 2007..Improvements in eye care seeking behaviors should help in avoiding visual loss from diabetic retinopathy and macula edema, the leading causes of visual loss in the working age Latino population. [unreadable] [unreadable]..
- CHARACTERIZATION OF DIFFERENT TYPES OF HUMAN MAST CELLSLawrence Schwartz; Fiscal Year: 2009..abstract_text> ..