cutaneous leishmaniasis

Summary

Summary: An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.

Top Publications

  1. ncbi Cutaneous leishmaniasis
    Richard Reithinger
    Clinical Trials Area, Westat, Rockville, MD 20850, USA
    Lancet Infect Dis 7:581-96. 2007
  2. ncbi The immunology of susceptibility and resistance to Leishmania major in mice
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:845-58. 2002
  3. ncbi Leishmaniasis
    B L Herwaldt
    Centers for Disease Control and Prevention, Division of Parasitic Diseases, Atlanta, GA 30341 3724, USA
    Lancet 354:1191-9. 1999
  4. ncbi [American cutaneous leishmaniasis]
    Bernardo Gontijo
    Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Rev Soc Bras Med Trop 36:71-80. 2003
  5. ncbi CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
    Damo Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Immunol 170:394-9. 2003
  6. ncbi Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
    Pascale Kropf
    Department of Immunology, Faculty of Medicine, Imperial College London, UK
    FASEB J 19:1000-2. 2005
  7. ncbi The role of nitric oxide in innate immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
    Immunol Rev 173:17-26. 2000
  8. ncbi CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:502-7. 2002
  9. ncbi The increase in risk factors for leishmaniasis worldwide
    P Desjeux
    Communicable Diseases Surveillance and Response, Epidemic Disease Control, World Health Organization, Geneva, Switzerland
    Trans R Soc Trop Med Hyg 95:239-43. 2001
  10. ncbi The role of IL-10 in promoting disease progression in leishmaniasis
    M M Kane
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 166:1141-7. 2001

Detail Information

Publications371 found, 100 shown here

  1. ncbi Cutaneous leishmaniasis
    Richard Reithinger
    Clinical Trials Area, Westat, Rockville, MD 20850, USA
    Lancet Infect Dis 7:581-96. 2007
    b>Cutaneous leishmaniasis is endemic in the tropics and neotropics...
  2. ncbi The immunology of susceptibility and resistance to Leishmania major in mice
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:845-58. 2002
    ..major-resistant mice have revealed complexities in the mechanisms responsible for acquired immunity, which necessitate the redesign of vaccines against Leishmania and other pathogens that require sustained cell-mediated immune responses...
  3. ncbi Leishmaniasis
    B L Herwaldt
    Centers for Disease Control and Prevention, Division of Parasitic Diseases, Atlanta, GA 30341 3724, USA
    Lancet 354:1191-9. 1999
    ....
  4. ncbi [American cutaneous leishmaniasis]
    Bernardo Gontijo
    Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Rev Soc Bras Med Trop 36:71-80. 2003
    American cutaneous leishmaniasis is endemic in widespread areas of Latin America. The causative agents include L. (V.) braziliensis, L. (L.) mexicana, L. (V.) panamensis, and related species...
  5. ncbi CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
    Damo Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Immunol 170:394-9. 2003
    ..Our results therefore document that CD4+CD25+ regulatory T cells suppress both Th1 and Th2 cells and that these regulatory T cells have a profound therapeutic potential against diseases induced by both Th1 and Th2 cells in vivo...
  6. ncbi Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
    Pascale Kropf
    Department of Immunology, Faculty of Medicine, Imperial College London, UK
    FASEB J 19:1000-2. 2005
    ..To address the underlying mechanisms, the arginase-induced L-arginine catabolism was investigated and the results demonstrate that arginase regulates parasite growth directly by affecting the polyamine synthesis in macrophages...
  7. ncbi The role of nitric oxide in innate immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
    Immunol Rev 173:17-26. 2000
    ..Some of these effects result from the function of NOS2/NO as an indispensable co-factor for the activation of Tyk2 kinase and, thus, for interleukin-12 and IFN-alpha/beta signaling in natural killer cells...
  8. ncbi CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 420:502-7. 2002
    ....
  9. ncbi The increase in risk factors for leishmaniasis worldwide
    P Desjeux
    Communicable Diseases Surveillance and Response, Epidemic Disease Control, World Health Organization, Geneva, Switzerland
    Trans R Soc Trop Med Hyg 95:239-43. 2001
    ..While some risk factors are related to a specific eco-epidemiological entity, others affect all forms of leishmaniasis. Risk factors are reviewed here entity by entity...
  10. ncbi The role of IL-10 in promoting disease progression in leishmaniasis
    M M Kane
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 166:1141-7. 2001
    To determine the role of IL-10 in cutaneous leishmaniasis, we examined lesion development following Leishmania major infection of genetically susceptible BALB/c mice lacking IL-10...
  11. ncbi CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major
    Yasmine Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, and Dermatology Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3992-4000. 2002
    Standard murine models of cutaneous leishmaniasis, involving s.c. inoculation of large numbers of Leishmania major promastigotes, have not supported an essential role for CD8(+) T cells in the control of primary infection. Recently, a L...
  12. pmc IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice
    Susanna Lopez Kostka
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 182:3039-46. 2009
    ..We now assessed the role of IL-17 in cutaneous leishmaniasis. During the course of Leishmania major infection, BALB/c CD4 cells and neutrophils produced increased ..
  13. ncbi Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?
    Diane McMahon-Pratt
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Immunol Rev 201:206-24. 2004
    ..These variations not only point to interesting features of the host-pathogen interaction and immunobiology of this genus of parasitic protozoa, but also have important implications for immunotherapy and vaccine development...
  14. ncbi IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice
    P Launois
    World Health Organization Immunology Research and Training Center, University of Lausanne, Epalinges, Switzerland
    Immunity 6:541-9. 1997
    ..Thus, the IL-4 required for Th2 development and susceptibility to L. major is produced by a restricted population of V beta 4 V alpha 8 CD4+ T cells after cognate interaction with a single antigen from this complex organism...
  15. ncbi Proven and putative vectors of American cutaneous leishmaniasis in Brazil: aspects of their biology and vectorial competence
    Elizabeth Ferreira Rangel
    Laboratório de Transmissores de Leishmanioses, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 104:937-54. 2009
    ..including the vectorial competence of Lutzomyia sand fly species suggested as vectors of American cutaneous leishmaniasis in Brazil...
  16. ncbi CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells
    Ana P Campanelli
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    J Infect Dis 193:1313-22. 2006
    ..Leishmania viannia braziliensis is the main etiologic agent of cutaneous leishmaniasis (CL) in Brazil, and it is also responsible for the more severe mucocutaneous form...
  17. ncbi Leishmaniasis and poverty
    Jorge Alvar
    Communicable Diseases, Neglected Tropical Diseases Control, World Health Organization, 20 Ave Appia, CH 1211 Geneva 27, Switzerland
    Trends Parasitol 22:552-7. 2006
    ..Public investment in treatment and control would decrease the leishmaniasis disease burden and help to alleviate poverty...
  18. ncbi Seasonality of Lutzomyia intermedia and Lutzomyia whitmani (Diptera: Psychodidae: Phlebotominae), occurring sympatrically in area of cutaneous leishmaniasis in the State of Rio de Janeiro, Brazil
    Nataly A Souza
    Departamento de Entomologia, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 97:759-65. 2002
    ..intermedia displayed greater density in the hottest months of the year (December, January, and February), L. whitmani was abundant in the coolest months (June, July, and August), although both occurred throughout the year...
  19. ncbi Clinical and immunopathological spectrum of American cutaneous leishmaniasis with special reference to the disease in Amazonian Brazil: a review
    Fernando T Silveira
    Departamento de Parasitologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministerio da Saude, Belem, PA, 66090 000, Brasil
    Mem Inst Oswaldo Cruz 99:239-51. 2004
    The wide variety of Leishmania species responsible for human American cutaneous leishmaniasis combined with the immune mechanisms of the host results in a large spectrum of clinical, histopathological, and immunopathological ..
  20. ncbi Comparison of meglumine antimoniate and pentamidine for peruvian cutaneous leishmaniasis
    Ellen M Andersen
    Navy Environmental and Preventive Medicine Unit No 5, San Diego, California 92136, USA
    Am J Trop Med Hyg 72:133-7. 2005
    Pentamidine was compared with meglumine antimoniate (Glucantime) for 80 patients with cutaneous leishmaniasis due to Leishmania braziliensis in Peru...
  21. pmc Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis
    P E Kima
    Division of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    J Exp Med 191:1063-8. 2000
    ..These observations establish a critical role for antibody in the pathogenesis associated with infection by members of the L. mexicana complex...
  22. pmc In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies
    Nathan C Peters
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 321:970-4. 2008
    ..Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease...
  23. pmc Genetic polymorphism and molecular epidemiology of Leishmania (Viannia) braziliensis from different hosts and geographic areas in Brazil
    Elisa Cupolillo
    Laboratório de Pesquisas em Leishmaniose Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
    J Clin Microbiol 41:3126-32. 2003
    ..V.) braziliensis genotypes with specific transmission cycles, probably reflecting an adaptation of different clones to the vector species involved...
  24. doi Species diversity of Leishmania (Viannia) parasites circulating in an endemic area for cutaneous leishmaniasis located in the Atlantic rainforest region of northeastern Brazil
    Maria Edileuza F Brito
    Departamento de Imunologia, Instituto Aggeu Magalhães, Fundacao Oswaldo Cruz, Recife PE CEP 50670 420, Brazil
    Trop Med Int Health 14:1278-86. 2009
    To identify the aetiological agents of cutaneous leishmaniasis and to investigate the genetic polymorphism of Leishmania (Viannia) parasites circulating in an area with endemic cutaneous leishmaniasis (CL) in the Atlantic rainforest ..
  25. ncbi Divergent expression of inflammatory dermal chemokines in cutaneous leishmaniasis
    Uwe Ritter
    Nikolaus Fiebiger Zentrum für Molekulare Medizin, University of Erlangen Nurnberg, Erlangen, Germany
    Parasite Immunol 24:295-301. 2002
    ..parasites and comprises a heterogeneous group of clinical appearances ranging from visceral to cutaneous leishmaniasis. In the New World, L...
  26. ncbi The combination of DNA vectors expressing IL-12 + IL-18 elicits high protective immune response against cutaneous leishmaniasis after priming with DNA-p36/LACK and the cytokines, followed by a booster with a vaccinia virus recombinant expressing p36/LACK
    Esther Tapia
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain
    Microbes Infect 5:73-84. 2003
    ..This combined prime/booster immunization regime could have wide use in fighting against parasitic and other infectious diseases...
  27. ncbi Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia species
    R Palacios
    Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
    Am J Trop Med Hyg 64:187-93. 2001
    Clinical response to supervised treatment of Colombian patients with cutaneous leishmaniasis was evaluated in a randomized controlled trial comparing 10 days versus 20 days of treatment with meglumine antimonate (20 mg Sb/kg/day)...
  28. pmc Up-regulation of Th1-type responses in mucosal leishmaniasis patients
    Olivia Bacellar
    Serviço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil
    Infect Immun 70:6734-40. 2002
    ..factor alpha (TNF-alpha) secretion and decreased IL-10 secretion compared to patients with classical cutaneous leishmaniasis. CD4(+) Th1 cells were the main source of IFN-gamma and TNF-alpha production in mucosal leishmaniasis ..
  29. doi The role of host genetics in leishmaniasis
    Anuratha Sakthianandeswaren
    The Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    Trends Parasitol 25:383-91. 2009
    ..This review summarizes recent advances in the identification of genetic loci involved in the host response to Leishmania spp. in the mouse model and in the human situation...
  30. ncbi Vaccines and vaccination strategies against human cutaneous leishmaniasis
    Ifeoma Okwor
    Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, CA
    Hum Vaccin 5:291-301. 2009
    One might think that the development of a vaccine against cutaneous leishmaniasis would be relatively straightforward because the type of immune response required for protection is known and natural immunity occurs following recovery ..
  31. ncbi Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs
    R Hadighi
    Department of Parasitology, Faculty of Medicine, Iran University of Medical Sciences, 14496, Tehran, Iran
    Parasitol Res 101:1319-22. 2007
    b>Cutaneous leishmaniasis (CL) is a major health problem in endemic areas of Iran...
  32. ncbi Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
    Patricia A Darrah
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, 40 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Med 13:843-50. 2007
    ....
  33. ncbi Leishmania-induced cellular recruitment during the early inflammatory response: modulation of proinflammatory mediators
    Claudine Matte
    Centre de Recherche en Infectiologie, CHU de Québec, Pavillon Centre Hospitalier de l Université Laval, Faculte de Medecine, Universite Laval, 2705 Boulevard Laurier, Sainte Foy, Quebec, Canada G1V 4G2
    J Infect Dis 185:673-81. 2002
    ..donovani, and suggest that such an immunologic event potentially could restrain this parasite to the inoculation site, favoring the development of local swelling and cutaneous lesions...
  34. ncbi PCR-RFLP to identify Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis causing American cutaneous leishmaniasis
    Angela C Volpini
    Lab de Parasitologia Celular e Molecular, Centro de Pesquisas René Rachou FIOCRUZ Av Augusto de Lima 1715, Barro Preto, CEP 30190 002, MG, Belo Horizonte, Brazil
    Acta Trop 90:31-7. 2004
    A PCR-RFLP based method was developed to diagnose and identify the Leishmania species causing American cutaneous leishmaniasis (ACL) in a panel of clinical samples obtained from an endemic region of Brazil...
  35. pmc Recruitment of CD8(+) T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis
    D R Faria
    Department of Morphology, ICB, Universidade Federal de Minas Gerais, CEP 31 270 901, Belo Horizonte, Minas Gerais, Brazil
    Parasite Immunol 31:432-9. 2009
    Human infection with Leishmania braziliensis leads to the establishment of cutaneous leishmaniasis (CL), characterized by the appearance of skin lesions that progress from nonulcerated to ulcerated forms...
  36. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ....
  37. pmc Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites
    Ramtin Hadighi
    School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
    PLoS Med 3:e162. 2006
    Recent circumstantial evidence suggests that an increasing number of Iranian patients with cutaneous leishmaniasis are unresponsive to meglumine antimoniate (Glucantime), the first line of treatment in Iran...
  38. doi Geographical distribution and epidemiological features of Old World cutaneous leishmaniasis foci, based on the isoenzyme analysis of 1048 strains
    Francine Pratlong
    Universite Montpellier 1, Centre National de Référence des Leishmania, Génétique et Evolution des Maladies Infectieuses, Laboratoire de Parasitologie Mycologie, CHU de Montpellier, France
    Trop Med Int Health 14:1071-85. 2009
    A series of 1048 Leishmania strains from Old World cutaneous leishmaniasis foci, isolated between 1981 and 2005, were studied by isoenzyme analysis. The strains were obtained from humans, rodents, dogs and sandflies from 33 countries...
  39. pmc Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity
    Susana Mendez
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:201-10. 2004
    ....
  40. ncbi TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis
    Jan Liese
    Institute of Medical Microbiology and Hygiene, Department of Medical Microbiology and Hygiene, University Clinic of Freiburg, Freiburg, Germany
    Eur J Immunol 37:3424-34. 2007
    ..We conclude that TLR9 signaling is essential for NK cell activation, but dispensable for a protective T cell response to L. major in vivo...
  41. ncbi IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice
    T Biedermann
    Department of Dermatology and Allergology, Ludwig Maximilians University Munich, Frauenlobstr 9 11, 80337 Munich, Germany
    Nat Immunol 2:1054-60. 2001
    ..Because immune responses developed via the consecutive activation of DCs and then T cells, the contrasting effects of IL-4 on DC development and T cell differentiation led to immune responses that had opposing functional phenotypes...
  42. pmc Climate cycles and forecasts of cutaneous leishmaniasis, a nonstationary vector-borne disease
    Luis Fernando Chaves
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Med 3:e295. 2006
    b>Cutaneous leishmaniasis (CL) is one of the main emergent diseases in the Americas...
  43. ncbi Persistence of leishmania parasites in scars after clinical cure of American cutaneous leishmaniasis: is there a sterile cure?
    Mitzi G Mendonça
    Departamento de Dermatologia, Universidade Federal de Pernambuco, Recife, Brazil
    J Infect Dis 189:1018-23. 2004
    It is uncertain whether Leishmania parasites ever disappear after clinical cure of American cutaneous leishmaniasis (ACL)...
  44. ncbi Randomized, double-blind clinical trial of topical imiquimod 5% with parenteral meglumine antimoniate in the treatment of cutaneous leishmaniasis in Peru
    C Miranda-Verastegui
    Department of Microbiology and Immunology, McGill University, Montreal, Canada
    Clin Infect Dis 40:1395-403. 2005
    Current treatments for cutaneous leishmaniasis are limited by their toxicity, high cost, and discomfort and the emergence of drug resistance. New approaches, including combination therapies, are urgently needed...
  45. ncbi Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity
    Esther von Stebut
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz
    Eur J Dermatol 17:115-22. 2007
    ..major infection and they are sequentially engaged via different pathogen recognition receptors as cutaneous leishmaniasis evolves. In the initial "silent" phase without clinically apparent inflammation, L...
  46. ncbi Urban distribution of Phlebotominae in a cutaneous leishmaniasis focus, Argentina
    Oscar D Salomon
    Centro Nacional de Diagnóstico e Investigación en Endemo epidemias, Buenos Aires, Argentina
    Mem Inst Oswaldo Cruz 103:282-7. 2008
    ..domestication are currently proposed as factors that contributed to the recent increase of American cutaneous leishmaniasis (ACL)...
  47. pmc First-line therapy for human cutaneous leishmaniasis in Peru using the TLR7 agonist imiquimod in combination with pentavalent antimony
    Cesar Miranda-Verastegui
    Universidad Peruana Cayetano Heredia, Lima, Peru
    PLoS Negl Trop Dis 3:e491. 2009
    Current therapies for cutaneous leishmaniasis are limited by poor efficacy, long-term course of treatment, and the development of resistance...
  48. ncbi Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling
    M Mohrs
    Max Planck Institute for Immunobiology, Freiburg, Germany
    J Immunol 162:7302-8. 1999
    ..major, mediated by a functional IL-13 receptor...
  49. ncbi Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice
    David Sacks
    Laboratory of Parasitic Diseases, NIAID, Bethesda, MD, USA
    Immunol Rev 201:225-38. 2004
    ....
  50. pmc The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil
    Rajendranath Ramasawmy
    Universidade Federal da Bahia, Salvador, Brazil
    Infect Genet Evol 10:607-13. 2010
    Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Proinflammatory responses mediate CL self-healing but are exaggerated in ML...
  51. pmc Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World
    G Salay
    Centro Interdisciplinar de Terapia Gênica, UNIFESP EPM, Rua Mirassol, 207, Sao Paulo, SP 04044 010, Brazil
    Clin Vaccine Immunol 14:1173-81. 2007
    ..We conclude that the protective immunity afforded by these four vaccine candidates against experimental cutaneous leishmaniasis caused by L. (L.) major could not be reproduced against a challenge with L. (V.) braziliensis...
  52. pmc IL-4-deficient Balb/c mice resist infection with Leishmania major
    M Kopf
    Basel Institute for Immunology, Switzerland
    J Exp Med 184:1127-36. 1996
    ..Moreover, the induction of inflammatory cytokines (e.g., IL-1 alpha, IL-1 beta, TNF-alpha, IL-12) together with iNOS in the lesion and draining lymph nodes was not altered in the absence of IL-4...
  53. pmc Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice
    Esther von Stebut
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Exp Med 198:191-9. 2003
    ..transient local administration of IL-1alpha acts in conjunction with IL-12 to influence Th-development in cutaneous leishmaniasis and prevents disease progression in susceptible BALB/c mice, perhaps by enhancing DC-induced Th1-..
  54. pmc CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokin
    N Sato
    South Texas Veterans Health Care System, Audie L Murphy Division, Austin, 78712 1095, USA
    J Exp Med 192:205-18. 2000
    ..major-susceptible genetic background. Thus, CCR2 is an important determinant of not only DC migration and localization but also the development of protective cell-mediated immune responses to L. major...
  55. pmc Toward a novel experimental model of infection to study American cutaneous leishmaniasis caused by Leishmania braziliensis
    Tatiana R de Moura
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Rua Waldemar Falcão, 121, Salvador, BA 40295 001, Brazil
    Infect Immun 73:5827-34. 2005
    ..Leishmania braziliensis is the main etiological agent of American cutaneous leishmaniasis (ACL) and mucocutaneous leishmaniasis...
  56. ncbi Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: therapeutic response to meglumine antimoniate
    G A Romero
    , , Brazil
    Am J Trop Med Hyg 65:456-65. 2001
    ..a quasi-experimental study to compare the response to meglumine antimoniate in patients with localized cutaneous leishmaniasis from two endemic areas of Brazil that were infected by two Leishmania species...
  57. ncbi IL6 -174 G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil
    Lea Castellucci
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    J Infect Dis 194:519-27. 2006
    ..ML follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis infection...
  58. pmc CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    Charles F Anderson
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:285-97. 2007
    ....
  59. pmc Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens
    Isabelle J Suffia
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:777-88. 2006
    ..Further, we showed that parasite-specific natural T reg cells are restricted to sites of infection and that their survival is strictly dependent on parasite persistence...
  60. pmc Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis
    E Bourreau
    Immunologie des Leishmanioses, Institut Pasteur de la Guyane, 97306 Cayenne, French Guyana
    Infect Immun 77:1465-74. 2009
    ..Treg cells), analyzed by Foxp3 mRNA expression, were determined in lesions from patients with acute cutaneous leishmaniasis (ACL) and chronic cutaneous leishmaniasis (CCL)...
  61. pmc CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major
    Z E Wang
    Department of Medicine, University of California San Francisco 94143
    J Exp Med 179:1367-71. 1994
    ..These data suggest that CD4+ T cells that normally respond to antigens by differentiation to Th1 cells default to the Th2 pathway in the absence of endogenous IFN-gamma...
  62. ncbi The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major
    Nancy Noben-Trauth
    Department of Immunology, George Washington University Medical Center, Washington, DC 20037, USA
    J Immunol 170:5152-8. 2003
    ..These studies suggest that regardless of parasite substrain, IL-10 is as important as IL-4/IL-13 in promoting susceptibility to L. major and even more so for those substrains that are relatively resistant to IFN-gamma mediated killing...
  63. ncbi Outbreak of cutaneous leishmaniasis in northern Israel
    Raymond L Jacobson
    Department of Parasitology, The Kuvin Center for Study of Infectious and Tropical Diseases, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Infect Dis 188:1065-73. 2003
    This study describes a new focus of cutaneous leishmaniasis (CL) due to Leishmania tropica, in the Galilee region of northern Israel...
  64. doi Cutaneous leishmaniasis caused by Leishmania infantum transmitted by Phlebotomus tobbi
    Milena Svobodova
    Department of Parasitology, Charles University, Vinicna 7, Prague 128 44, Czech Republic
    Int J Parasitol 39:251-6. 2009
    Transmission of cutaneous leishmaniasis (CL) caused by Leishmania infantum was studied in South Anatolia, Turkey...
  65. doi Nested PCRs and sequencing of nuclear ITS-rDNA fragments detect three Leishmania species of gerbils in sandflies from Iranian foci of zoonotic cutaneous leishmaniasis
    P Parvizi
    Molecular Systematics Laboratory, Pasteur Institute of Iran, Tehran, Iran
    Trop Med Int Health 13:1159-71. 2008
    ..To identify and understand the natural transmission cycles of Leishmania in Iranian sandflies...
  66. ncbi Lutzomyia vectors for cutaneous leishmaniasis in Southern Brazil: ecological niche models, predicted geographic distributions, and climate change effects
    A Townsend Peterson
    Natural History Museum, The University of Kansas, Lawrence, KS 66045, USA
    Int J Parasitol 33:919-31. 2003
    Geographic and ecological distributions of three Lutzomyia sand flies that are cutaneous leishmaniasis vectors in South America were analysed using ecological niche modelling...
  67. doi Immunopathogenic competences of Leishmania (V.) braziliensis and L. (L.) amazonensis in American cutaneous leishmaniasis
    F T Silveira
    Parasitology Department, Evandro Chagas Institute Surveillance Secretary of Health, Ministry of Health, 66090 000, Belem, Pará State, Brazil
    Parasite Immunol 31:423-31. 2009
    ..in the light of more recent features found in the clinical and immunopathological spectrum of American cutaneous leishmaniasis. It was shown a dichotomy in the interaction between these Leishmania species and human T-cell immune ..
  68. ncbi Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis
    Lis R V Antonelli
    Department of Biochemistry Immunology, Institute of Biological Sciences Federal University of Minas Gerais UFMG ICB, Av Antonio Carlos, 6627 Belo Horizonte, MG 31640 970, Brazil
    Immunol Lett 101:226-30. 2005
    ..These studies demonstrate that immunological markers are correlated with clinical indicators of human leishmaniasis and serve to better understand the evolution of this important parasitic disease...
  69. ncbi The epidemic threshold of vector-borne diseases with seasonality: the case of cutaneous leishmaniasis in Chichaoua, Morocco
    Nicolas Bacaer
    IRD, 32 avenue Henri Varagnat, Bondy 93143, France
    J Math Biol 53:421-36. 2006
    b>Cutaneous leishmaniasis is a vector-borne disease transmitted to humans by sandflies...
  70. pmc Applying TLR synergy in immunotherapy: implications in cutaneous leishmaniasis
    Vanitha S Raman
    Infectious Disease Research Institute, Seattle, WA 98104, USA
    J Immunol 185:1701-10. 2010
    ..We have attempted to develop an improved and defined immunotherapeutic using a mouse model of cutaneous leishmaniasis. We hypothesized that immunotherapy may be improved by using TLR synergy to enhance the parasite-specific ..
  71. doi Cutaneous leishmaniasis: advances in disease pathogenesis, diagnostics and therapeutics
    M Ameen
    Royal Free Hospital, Royal Free Hampstead NHS Trust, London, UK
    Clin Exp Dermatol 35:699-705. 2010
    b>Cutaneous leishmaniasis is one of the most common tropical dermatoses worldwide and is of major public health importance. It is caused by numerous Leishmania protozoa species, which are responsible for its clinical diversity...
  72. ncbi A heterologous prime-boost regime using DNA and recombinant vaccinia virus expressing the Leishmania infantum P36/LACK antigen protects BALB/c mice from cutaneous leishmaniasis
    Rosa M Gonzalo
    Department of Molecular and Cellular Biology, , , CSIC, 28049, Madrid, Spain
    Vaccine 20:1226-31. 2002
    ..DNA prime-VVr boost before challenge elicited a Th1 type immune response in spleen cells from immunized animals. This DNA/VVr vaccination approach could be of utility in the prophylaxis against leishmaniasis...
  73. ncbi Safety, immunogenecity, and efficacy of an autoclaved Leishmania amazonensis vaccine plus BCG adjuvant against New World cutaneous leishmaniasis
    R X Armijos
    Health Sciences Program, College of Health Sciences, University of Texas at El Paso, Room 705, 1101 North Campbell Street, El Paso, TX 79902 0581, USA
    Vaccine 22:1320-6. 2004
    ..whole cell Leishmania amazonensis vaccine (IFLA/BR/67/PH8) and BCG adjuvant (n = 750) against cutaneous leishmaniasis (CL) was compared with placebo (n = 756) in a randomized, placebo-controlled, blinded study...
  74. doi A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis
    Evaldo Nascimento
    Universidade Federal de Minas Gerais e Centro de Ensino e Pesquisa do Hospital Santa Casa de Belo Horizonte, MG, Brazil
    Vaccine 28:6581-7. 2010
    Forty-four adult patients with cutaneous leishmaniasis (CL) were enrolled in a randomized, double-blind, controlled, dose-escalating clinical trial and were randomly assigned to receive three injections of either the LEISH-F1+MPL-SE ..
  75. pmc Enhanced replication of Leishmania amazonensis amastigotes in gamma interferon-stimulated murine macrophages: implications for the pathogenesis of cutaneous leishmaniasis
    Hai Qi
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Infect Immun 72:988-95. 2004
    ..These results reveal a quite unexpected aspect of the L. amazonensis parasite and have important implications for understanding the pathogenesis of the disease and for developing vaccines and immunotherapies...
  76. ncbi B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases
    M G S Vieira
    Faculdade de Medicina, Universidade Federal da Bahias, Salvador, BA, Brasil
    Mem Inst Oswaldo Cruz 97:979-83. 2002
    ....
  77. ncbi Retrospective study of 151 patients with cutaneous leishmaniasis treated with meglumine antimoniate
    Armando de Oliveira Schubach
    Centro de Referências em Leishmanioses, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    Rev Soc Bras Med Trop 38:213-7. 2005
    We retrospectively analyzed a series of 151 cases of cutaneous leishmaniasis treated between 1967 and 1982...
  78. ncbi Abundance of Lutzomyia ovallesi but not Lu. gomezi (Diptera: Psychodidae) correlated with cutaneous leishmaniasis incidence in north-central Venezuela
    M D Feliciangeli
    Facultad de Ciencias de la Salud, Universidad de Carabobo, and Escuela de Malariología Dr Arnoldo Gabaldón
    Med Vet Entomol 12:121-31. 1998
    ..are the main endophilic/anthropophilic species of phlebotomine sandflies implicated as vectors of cutaneous leishmaniasis (CL). Lutzomyia ovallesi has been found infected with Leishmania braziliensis (1...
  79. pmc Comparison of PCR assays for diagnosis of cutaneous leishmaniasis
    Esther Bensoussan
    Department of Parasitology, P O Box 12272, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Clin Microbiol 44:1435-9. 2006
    ..cultures and microscopic evaluation of stained tissue smears using 92 specimens from suspected cases of cutaneous leishmaniasis (CL) in Israel and the West Bank. Samples from imported and locally acquired disease were examined...
  80. ncbi Ecology of American cutaneous leishmaniasis in the state of Rio de Janeiro, Brazil
    Cláudio Roberto Valente Meneses
    Departamento de Entomologia, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, RJ CEP 21045 900, Brazil
    J Vector Ecol 27:207-14. 2002
    A study of the sand fly fauna was carried out in the endemic area ofAmerican cutaneous leishmaniasis (ACL) in the Municipality of Mesquita, State of Rio de Janeiro, in an area where dwellings (with humans and dogs infected by Leishmania (..
  81. ncbi [Epidemiological and clinical study of 332 cases of cutaneous leishmaniasis in the north of Parana State from 1993 to 1998]
    Edilene Alcântara de Castro
    Laboratório de Parasitologia Molecular do Departamento de Patologia Básica do Setor de Ciências Biológicas da Universidade Federal do Paraná
    Rev Soc Bras Med Trop 35:445-52. 2002
    Cases of cutaneous leishmaniasis (CL) in northern Parana State have been reported since the 1950's, but towards the end of the 1980's there has been an increase in the number of human infections...
  82. ncbi Clinical, epidemiological and laboratory aspects of patients with American cutaneous leishmaniasis in the State of Pernambuco
    Luiza de Campos Reis
    Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Recife, PE, Brasil
    Rev Soc Bras Med Trop 41:439-43. 2008
    The diagnosis for American cutaneous leishmaniasis is based on an association of clinical, epidemiological and laboratory characteristics...
  83. ncbi Frequency of infection of Lutzomyia phlebotomines with Leishmania braziliensis in a Brazilian endemic area as assessed by pinpoint capture and polymerase chain reaction
    Jose Carlos Miranda
    Centro de Pesquisas Goncalo Moniz, Fundação Instituto Oswaldo Cruz, 40295 001, Salvador, BA, Brasil
    Mem Inst Oswaldo Cruz 97:185-8. 2002
    ..Incidence of American cutaneous leishmaniasis cases for this sector was about twice that for other sectors...
  84. ncbi Phlebotominae (Diptera: Psycodidae) fauna in the Chaco region and Cutaneous Leishmaniasis transmission patterns in Argentina
    Oscar D Salomon
    Centro Nacional de Diagnóstico e Investigación en Endemo epidemias, Buenos Aires, Argentina
    Mem Inst Oswaldo Cruz 103:578-84. 2008
    In Argentina, the incidence of American Cutaneous Leishmaniasis (ACL) has shown a steady increase over the last few decades...
  85. ncbi WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection
    H Yoshida
    The Amgen Institute, Toronto, Ontario M5G 2C1, Canada
    Immunity 15:569-78. 2001
    ..Thus, WSX-1 is essential for the initial mounting of Th1 responses but dispensable for their maintenance...
  86. ncbi Zoonotic cutaneous leishmaniasis in central Tunisia: spatio temporal dynamics
    Afif Ben Salah
    Laboratory of Epidemiology and Ecology of Parasitic Diseases, Institut Pasteur de Tunis, Tunis Belvedere, Tunisia
    Int J Epidemiol 36:991-1000. 2007
    Zoonotic cutaneous leishmaniasis (ZCL) is endemic in many rural areas of the Southern and Eastern Mediterranean region where different transmission patterns of the disease have been described...
  87. ncbi Lesion aspirate culture for the diagnosis and isolation of Leishmania spp. from patients with cutaneous leishmaniasis
    Zélia Maria Profeta Luz
    Laboratório de Pesquisas Clínicas, Centro de Referência em Leishmanioses, Instituto René Rachou, FIOCRUZ, Belo Horizonte, MG, Brasil, 30190 002
    Mem Inst Oswaldo Cruz 104:62-6. 2009
    ..in skin lesion aspirates, using a puncture technique, was evaluated in 76 patients with cutaneous leishmaniasis (CL) who were referred to a Leishmaniasis Reference Centre in Brazil...
  88. ncbi A multifaceted intervention to prevent American cutaneous leishmaniasis in Colombia: results of a group-randomized trial
    Carlos A Rojas
    Grupo de Epidemiologia, Facultad Nacional de Salud Pública, Universidad de Antioquia, Medellin, Colombia
    Biomedica 26:152-66. 2006
    American cutaneous leishmaniasis is endemic in Colombia, where approximately 6.000 new cases are reported every year. Current prevention and control measures are restricted to the diagnosis and treatment of cases.
  89. ncbi An outbreak of cutaneous leishmaniasis among soldiers in Belém, Pará State, Brazil, caused by Leishmania (Viannia) lindenbergi n. sp. A new leishmanial parasite of man in the Amazon region
    F T Silveira
    Departamento de Parasitologia, Instituto Evandro Chagas FNS, Caixa Postal 1128, Belem, Para, Brazil
    Parasite 9:43-50. 2002
    Eight cases of cutaneous leishmaniasis are recorded among soldiers of the Brazilian Forest Infantry stationed in Belém, State of Pará, north of Brazil...
  90. ncbi Epidemiological studies of an outbreak of cutaneous leishmaniasis in the Rio Jequitinhonha Valley, Minas Gerais, Brazil
    C M F Gontijo
    Laboratório de Leishmanioses, Centro de Pesquisas Rene Rachou Fiocruz, Fundação Oswaldo Cruz Av Augusto de Lima, 1715, Belo Horizonte, MG 30190 002, Brazil
    Acta Trop 81:143-50. 2002
    We detected an outbreak of American cutaneous leishmaniasis in the Jequitinhonha River Valley, Minas Gerais, Brazil. Clinical and epidemiological aspects were studied for a period of two years...
  91. ncbi Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis
    Angélica Olivo-Díaz
    Department of Immunogenetics, Instituto de Diagnostico y Referencia Epidemiologicos, Mexico City, Mexico
    Hum Immunol 65:255-61. 2004
    Localized cutaneous leishmaniasis (LCL) is the prevalent form of leishmaniasis in Mexico. It is limited to the skin; reversible upon treatment and the host cellular immune response is intact...
  92. pmc Clinical and demographic stratification of test performance: a pooled analysis of five laboratory diagnostic methods for American cutaneous leishmaniasis
    Andrea K Boggild
    Division of Infectious Diseases, University Health Network Toronto General Hospital, Toronto, Ontario, Canada
    Am J Trop Med Hyg 83:345-50. 2010
    We evaluated performance characteristics of five diagnostic methods for cutaneous leishmaniasis. Patients who came to the Leishmania Clinic of Hospital Nacional Cayetano Heredia in Lima, Peru, were enrolled in the study...
  93. ncbi Mathematical modelling of American cutaneous leishmaniasis: incidental hosts and threshold conditions for infection persistence
    Luis Fernando Chaves
    Laboratorio de Biología Teórica and Postgrado en Ecología, Instituto de Zoologia Tropical, Facultad de Ciencias, Universidad Central de Venezuela, Apartado Postal 47058, Caracas 1041 A, Venezuela
    Acta Trop 92:245-52. 2004
    We present a model for the dynamics of transmission of American Cutaneous Leishmaniasis (ACL) that includes a population of incidental hosts for parasites (that is, they act only as sinks of infection), along with species that are ..
  94. ncbi Concomitant early mucosal and cutaneous leishmaniasis in Brazil
    Viviane S Boaventura
    Centro de Pesquisas Gonçalo Moniz FIOCRUZ, Fundacao Oswaldo Cruz, Salvador, Bahia, Brazil
    Am J Trop Med Hyg 75:267-9. 2006
    ..In this prospective study, 6 of 220 patients with early cutaneous leishmaniasis were diagnosed with mucosal involvement by otorhinolaryngological examination (a rate similar to the ..
  95. pmc Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors
    Rajesh Kumar
    Institute of Pathology ICMR, Safdarjung Hospital Campus, New Delhi
    Immunology 130:193-201. 2010
    We have established Leishmania tropica as the causative agent of cutaneous leishmaniasis (CL) in the region of India where the disease is endemic...
  96. ncbi Species diversity causing human cutaneous leishmaniasis in Rio Branco, state of Acre, Brazil
    Anna Christina Tojal da Silva
    Nucleo de Medicina Tropical, Universidade de Brasilia, Campus Darcy Ribeiro, Brasilia, DF, and Serviço de Imunologia, Hospital Universitario Professor Edgar Santos, Salvador, Brazil
    Trop Med Int Health 11:1388-98. 2006
    Information on Leishmania species diversity in western Brazilian Amazon and the clinical picture of human cutaneous leishmaniasis it causes is scarce...
  97. ncbi Soluble CD26 and CD30 levels in patients with anthroponotic cutaneous leishmaniasis
    Soheila Ajdary
    Immunology Department, Pasteur Institute of Iran, Pasteur Avenue, Tehran 13164, Iran
    J Infect 55:75-8. 2007
    Leishmania tropica is the causative agent of anthroponotic cutaneous leishmaniasis (CL) in Iran. The disease often heals within a year; however, the non-healing forms of disease are also known...
  98. doi Clinical and parasite species risk factors for pentavalent antimonial treatment failure in cutaneous leishmaniasis in Peru
    Alejandro Llanos-Cuentas
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Clin Infect Dis 46:223-31. 2008
    Treatment for cutaneous leishmaniasis (CL) with standard pentavalent antimonial therapy is hampered by cumbersome administration, toxicity, and potential failure...
  99. pmc Expression of inducible nitric oxide synthase in skin lesions of patients with american cutaneous leishmaniasis
    Muna Qadoumi
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
    Infect Immun 70:4638-42. 2002
    ..by immunohistological analysis of skin biopsies from Mexican patients with local (LCL) or diffuse (DCL) cutaneous leishmaniasis that the expression of iNOS was most prominent in LCL lesions with small numbers of parasites whereas ..
  100. ncbi [The laboratory diagnosis and epidemiology of cutaneous leishmaniasis in Paraná State, southern Brazil]
    T G Silveira
    Departamento de Análises Clínicas da Universidade Estadual de Maringá, PR, Brasil
    Rev Soc Bras Med Trop 32:413-23. 1999
    ..at the Clinical Analysis Teaching and Research Laboratory of Maringá State University (LEPAC/UEM) for cutaneous leishmaniasis by direct examination of stained smears made from the lesions, the Montenegro skin test and the indirect ..
  101. pmc Leishmania tropica in rock hyraxes (Procavia capensis) in a focus of human cutaneous leishmaniasis
    Dalit Talmi-Frank
    School of Veterinary Medicine, Hebrew University, Rehovot, Israel
    Am J Trop Med Hyg 82:814-8. 2010
    b>Cutaneous leishmaniasis, caused by Leishmania tropica, has recently emerged in urban and rural foci of central and northern Israel, and constitutes a major public health concern...

Research Grants62

  1. New drugs for the treatment of leishmaniasis
    Claude Selitrennikoff; Fiscal Year: 2004
    ..The annual incidence of new cases is about 2 million (1.5 million of cutaneous leishmaniasis, and 500,000 of visceral leishmaniasis)...
  2. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..In this proposal we will amplify these proof-of-concept studies and expand them to rodent models of cutaneous leishmaniasis to determine the potential of this technology against these devastating parasitic diseases...
  3. Treating cutaneous leishmaniasis by radio-frequency induced heat (RFH) therapy
    Abhay R Satoskar; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Cutaneous leishmaniasis is caused by Leishmania parasites...
  4. Toward suicidal automation of porphyric Leishmania for photodynamic vaccination
    Kwang Poo Chang; Fiscal Year: 2010
    ..In addition, some species are relatively innocuous, causing human simple cutaneous leishmaniasis, which is known to heal spontaneously, resulting in life-long immunity...
  5. PATHOGENIC MECHANISMS OF CUTANEOUS LEISHMANIASIS
    Lynn Soong; Fiscal Year: 2012
    ..factors in both Specific Aims, we have parasite stocks derived from patients with localized or diffuse cutaneous leishmaniasis, as well as genetically modified parasites with reduced virulence or tractable markers...
  6. Characterization of CCR5-like Molecules in Leishmania
    Lynn Soong; Fiscal Year: 2010
    ..amazonensis (La) infection. A hallmark of cutaneous leishmaniasis associated with La infection is the profound deficiency in cellular immunity to the parasite...
  7. Photo-inactivation of Leishmania for safe and effective delivery of surrogate vac
    Kwang Poo Chang; Fiscal Year: 2013
    ..the observation that life-long lasting immunity ensue invariably after spontaneous cure of human simple cutaneous leishmaniasis. Moreover, in natural infection, not only do Leishmania resist humoral lytic factors and parasitize ..
  8. Targeting Entry Pathways in Leishmaniasis
    DAWN MARIE WETZEL; Fiscal Year: 2013
    ..macrophages, and 3) drugs that can inhibit these signaling proteins will decrease the manifestations of cutaneous leishmaniasis in mice...
  9. Nucleoside hydrolase Inhibitors from natural products for Leishmania
    ESTEBAN EDWARD MENA; Fiscal Year: 2010
    ..States as many Desert Storm veterans were exposed to sand flies;approximately 700 confirmed cases of cutaneous leishmaniasis were reported in 2003-2004 in soldiers returning from Iraq and Kuwait...
  10. Cutaneous Leishmaniasis in West Africa: the Parasite, Vector and Disease
    Seydou Doumbia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cutaneous leishmaniasis (CL) has a long history in West Africa, but one of the less recognized parasitic infections in the region...
  11. A transfollicular nanovaccine against leishmaniasis
    PAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2012
    ..S. military today, with over 2500 U.S. military personnel diagnosed with cutaneous leishmaniasis (CL)...
  12. Role of B cells in the Cell-Mediated Immune Response to Leishmania amazonensis
    Katherine Nicole Gibson Corley; Fiscal Year: 2010
    ..infection and all will provide a foundation for development of treatment and vaccine options of cutaneous leishmaniasis in animals and humans...
  13. L. major infection: Natural history and determinants of resistance
    Afif Ben Salah; Fiscal Year: 2011
    ..major infection and to weight the relative importance of host related risk factors of cutaneous leishmaniasis (CL) emergence and severity considering the confounding effect of environmental factors influencing ..
  14. LEISHMANIA ANTIGENS DEFINED BY HUMAN IMMUNE RESPONSES
    STEVEN GREGORY REED; Fiscal Year: 2013
    ..major, cause cutaneous leishmaniasis (CL)...
  15. Study of cutaneous leishmaniasis in Sri Lanka caused by L.donovani
    NADIRA DHARSHANI KARUNAWEERA; Fiscal Year: 2013
    ..donovani that cause cutaneous leishmaniasis (CL) in Sri Lanka...
  16. Myeloid-lineage cells and immunopathology in Leishmania braziliensis
    Phillip A Scott; Fiscal Year: 2013
    ..we will evaluate circulating and tissue-localized myeloid cells at a phenotypic and functional level in cutaneous leishmaniasis patients in Brazil...
  17. Natural Product Treatments for Leishmaniasis
    Dennis E Kyle; Fiscal Year: 2013
    ..Two million new cases of leishmaniasis occur annually (1.5 million for cutaneous leishmaniasis and 500,000 for visceral leishmaniasis and over 350 million people are at risk of acquiring leishmaniasis,..
  18. Improved Treatment of American Cutaneous Leishmaniasis by Immunomodulation
    Nancy Saravia; Fiscal Year: 2013
    ..Passive case detection and treatment constitute the principal, often the sole measure of control for cutaneous leishmaniasis (CL) in Central and South America yet first line therapies (pentavalent antimonials, pentamidine and ..
  19. L. Brazilensis Vaccine Antigens and T-cell Quality in Protection
    Lynn Soong; Fiscal Year: 2013
    ..adjuvants, can elicit a broad-spectrum and high-quality T-cell immunity for the control of American cutaneous leishmaniasis. This hypothesis will be tested in two Specific Aims. Aim 1 will examine whether L...
  20. Macrophage drug transport and metabolism in the outcome of antileishmania therapy
    Maria Adelaida Gomez; Fiscal Year: 2013
    ..To optimize the usefulness of available chemotherapy for cutaneous leishmaniasis caused by Leishmania Viannia, this project seeks to identify host biomarkers associated with successful ..
  21. Profiling the Leishmania-macrophage Host-pathogen Infectome
    David M Mosser; Fiscal Year: 2013
    ..In this study, we focus on the protozoan parasite Leishmania major, the causative agent of human cutaneous leishmaniasis. While significant progress has been made over the past 20 years toward understanding the molecular and ..
  22. Sterol Biosynthesis in Trypanosomatid Parasites
    Frederick Buckner; Fiscal Year: 2004
    ..Visceral leishmaniasis is fatal if untreated and cutaneous leishmaniasis causes serious morbidity, Chagas disease is caused by Trypanosoma cruzi and is endemic in over 20 ..
  23. The role of sand fly saliva in visceralization of Leishmania parasites
    Gregory Lanzaro; Fiscal Year: 2009
    ..All studies to date aimed at exploring the effects of sand fly saliva have examined its effects on cutaneous leishmaniasis. In this proposal we aim to examine the affects of the saliva of Lutzomyia longipalpis on the development ..
  24. Antileishmanial Lead Optimization of Quinazolines
    Karl A Werbovetz; Fiscal Year: 2013
    ..provided by applicant): There is a need for new oral drugs to treat visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL)...
  25. Leishmania major nucleoside hydrolase inhibitors
    Claude Selitrennikoff; Fiscal Year: 2007
    ..The annual incidence of new cases is about 2 million (1.5 million of cutaneous leishmaniasis, and 500,000 of visceral leishmaniasis)...
  26. A nanoparticle-based vaccine against leishmaniasis
    DIANE MCMAHON PRATT; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): We propose to develop a recombinant subunit vaccine against cutaneous leishmaniasis. This vaccine will incorporate two protein antigens, TSA/TryP and P-4...
  27. Intervenable Host Leishmania (Viannia) Interactions
    DIANE MCMAHON PRATT; Fiscal Year: 2009
    ..PROJECT 1: Miltefosine in Pediatric Cutaneous Leishmaniasis (McMahon-Pratt, D...
  28. FOUR TROPICAL DISEASES IN BRAZIL
    John David; Fiscal Year: 1993
    ..The epidemiology project in Amazonas, unique in its design and scope, is concerned with the spread of cutaneous leishmaniasis in Cidade Nova, a new development adjacent to the forest...
  29. Transgenic porphyric Leishmania as suicidal live vaccines against leishmaniasis
    Kwang Poo Chang; Fiscal Year: 2007
    ..g. BALB/c mouse, susceptible to cutaneous leishmaniasis by challenging them with the cutaneous species, i.e. Leishmania amazonensis...
  30. Phylogeography of Verrucarum sand fly disease vectors
    Leonard Munstermann; Fiscal Year: 2006
    ..of the Verrucarum group, Lutzomyia verrucarum (bartonellosis vector) and Lutzomyia serrana (probable cutaneous leishmaniasis vector), in order to detect cryptic species and evaluate the relative significance of geographic barriers ..
  31. IMMUNOLOGY & VACCINES FOR LEPROSY & LEISHMANIASIS
    Barry Bloom; Fiscal Year: 1993
    ..derives from a longstanding collaborative research effort on leprosy which we hope to extend to American cutaneous leishmaniasis as well. A number of fundamental approaches to understanding the nature of protective antigens of M...
  32. Leish-111f + MPL-SE vaccine development for treatment of cutaneous leishmaniasis
    FRANCO PIAZZA; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Cutaneous leishmaniasis (CL) is an infectious disease caused by the parasite Leishmania and transmitted by the bite of a small fly that occurs in tropical and subtropical regions ..
  33. Isolation of novel antileishmanial molecules from Pentalinon andrieuxii root
    Abhay Satoskar; Fiscal Year: 2009
    ..b>Cutaneous leishmaniasis (CL) manifests as localized skin lesions which may heal or become chronic leading to significant tissue ..
  34. Treatment of cutaneous leishmaniasis using Pentalinon andrieuxii root extract
    Abhay R Satoskar; Fiscal Year: 2010
    ..b>Cutaneous leishmaniasis (CL) manifests as localized skin lesions which may heal or lead to significant tissue destruction and ..
  35. LOCAL T-CELL RESPONSE IN HUMAN LEISHMANIASIS
    Robert Modlin; Fiscal Year: 1999
    Infection by Leishmania braziliensis is the major cause of American cutaneous leishmaniasis (ACL) in Brazil...
  36. Mechanisms of sex-determined resistance to L. mexicana
    Abhay Satoskar; Fiscal Year: 2005
    ..We have found that female mice are relatively more resistant visceral and cutaneous leishmaniasis than the male mice. In the L...
  37. Role of T reg in live vaccination against leishmaniasis
    Susana Mendez; Fiscal Year: 2005
    Leishmania major (Lm) is the causative agent of zoonotic cutaneous leishmaniasis (ZCL), the most widely distributed form of ZCL in the Old World...
  38. SCORE Program at the University of the Incarnate Word
    Sara Kerr; Fiscal Year: 2004
    ..Sara Kerr and Dr. Chad McHugh will study the zoonotic cycle of cutaneous leishmaniasis in the U.S...
  39. HISTONE LIKE PROTEINS ASSOCIATED WITH KINETOPLAST DNA
    DAN RAY; Fiscal Year: 2002
    ..Adapted from the Applicant's Abstract): Kinetoplastid protozoa are the causative agents of visceral and cutaneous leishmaniasis, sleeping sickness and Chagas' disease in much of the tropical and subtropical world...
  40. BIOMEDICAL RESEARCH IN A TROPICAL ENVIRONMENT
    RICHARD ROSSAN; Fiscal Year: 1990
    ..in the monkey model (Aotus), other studies on malaria, clinical characterization and chemotherapy of cutaneous leishmaniasis, dengue surveillance, influenza, and tropical biology...
  41. Novel immune-based therapy for leishmaniasis and tuberculosis
    Christopher Karp; Fiscal Year: 2009
    ..Specifically, our data indicate that: (a) IDO is counter-regulatory in cutaneous leishmaniasis (restraining inflammation and parasite clearance);(b) IDO is an antimicrobial effector in toxoplasmosis;..
  42. FINDING GENES FOR HOST RESPONSE TO LEISHMANIA MAJOR
    Simon Foote; Fiscal Year: 2004
    ..b>Cutaneous leishmaniasis, caused by the parasite L...
  43. T CELL SUBSETS IN CUTANEOUS LEISHMANIASIS
    JAY FARRELL; Fiscal Year: 2000
    ....
  44. CUTANEOUS LEISHMANIASIS: RELATIVE ROLE OF T CELL SUBSETS
    Richard Titus; Fiscal Year: 1991
    Immunity in cutaneous leishmaniasis has been linked to the activities of parasite-specific T cells. Previous work by the applicant has shown that L3T4+ L...
  45. VACCINE FOR LEISHMANIASIS
    Steven Reed; Fiscal Year: 2000
    ..This will be accomplished by using the best available models for experimental visceral and cutaneous leishmaniasis. Antigen combinations that are optimal for achieving long lasting protection will be developed; adjuvants ..
  46. Vaccine Development in Leishmaniasis
    Phillip Scott; Fiscal Year: 2006
    ..Overall, these experiments will establish the parameters for using LPG2 KO parasites as a vaccine in non-human primates, and provide basic information of wider importance in developing a leishmanial vaccine. [unreadable] [unreadable]..
  47. Gammacell-40 Exactor Research Irradiator
    Phillip Scott; Fiscal Year: 2007
    ..Each of these will advance our understanding of human diseases. [unreadable] [unreadable] [unreadable]..
  48. Initiation Of Immune Responses in Chronic Leishmaniasis
    Phillip Scott; Fiscal Year: 2008
    ..Taken together, these experiments should provide the foundation for the development of new immunotherapies for chronic leishmaniasis. ..
  49. GAMMA/DELTA T CELLS AND PATHOGEN INDUCED IMMUNE RESPONSE
    Phillip Scott; Fiscal Year: 2003
    ..abstract_text> ..
  50. CYSTEINE PROTEINASES AS LEISHMANIAL VIRULENCE FACTORS
    LAURENCE BUXBAUM; Fiscal Year: 2002
    ..D. and Ph.D. degrees, with thesis research in the GPI anchor of African trypanosomes. He has completed his clinical training in Internal Medicine and a clinical year of Infectious Diseases at the University of Pennsylvania. ..
  51. MOLECULAR TOOLS TO DEVELOP HAMSTER MODELS OF DISEASE
    Peter Melby; Fiscal Year: 2003
    ..This work will have particular relevance to research traditionally funded through a number of NIH institutes including the NCI, NIAID, NHLBI, NIA, NIAMS, and NIDR. ..
  52. VACCINATION OF DOGS TO REDUCE TRANSMISSION OF LEISHMANIA
    Peter Melby; Fiscal Year: 2003
    ..Successful vaccination of dogs in an endemic could reduce both enzootic (among the canine reservoir) and zoonotic (from the canine reservoir to humans) transmission. ..
  53. Genetics of Innate Immunity in Human Leptospirosis in Brazil
    Joseph Vinetz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. MOLECULAR TARGETS OF BLOCKING MALARIA TRANSMISSION
    Joseph M Vinetz; Fiscal Year: 2010
    ..falciparum chitinase, PfCHTI, and provide the scientific basis for developing novel potential approaches to interrupting malaria transmission at the vertebrate host-mosquito vector interface. ..
  55. Leptospirosis Transmission in the Peruvian Amazon
    Joseph Vinetz; Fiscal Year: 2006
    ....
  56. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph M Vinetz; Fiscal Year: 2010
    ..vivax, and provide a rational basis for determining strategies to implement and deploy new transmission- blocking vaccines as one approach towards the future elimination of P. vivax malaria from the Amazon basin. ..
  57. Microarray Analysis of Leptospiral Genomes
    Joseph Vinetz; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. International Leptospirosis Society Meeting 2007
    Joseph Vinetz; Fiscal Year: 2007
    ..unreadable] Outcome of the meeting will be assessed by peer-reviewed publication and trainee publication and[unreadable] career advancement. ..
  59. NOS2 and arginase in visceral leishmaniasis
    Peter Melby; Fiscal Year: 2009
    ..These studies in the hamster will fill a knowledge gap by defining mechanisms of disease and immunity that are strikingly different from those of the murine model. ..