strongyloidiasis

Summary

Summary: Infection with nematodes of the genus STRONGYLOIDES. The presence of larvae may produce pneumonitis and the presence of adult worms in the intestine could lead to moderate to severe diarrhea.

Top Publications

  1. ncbi Strongyloides stercoralis: a field-based survey of mothers and their preschool children using ELISA, Baermann and Koga plate methods reveals low endemicity in western Uganda
    J R Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, Cromwell Road, London, UK
    J Helminthol 82:263-9. 2008
  2. pmc Strongyloidiasis in transplant patients
    Alison C Roxby
    Division of Allergy and Infectious Diseases, University of Washington, Seattle, USA
    Clin Infect Dis 49:1411-23. 2009
  3. pmc High throughput multiplex PCR and probe-based detection with Luminex beads for seven intestinal parasites
    Mami Taniuchi
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA22908, USA
    Am J Trop Med Hyg 84:332-7. 2011
  4. ncbi Diagnosis of Strongyloides stercoralis infection
    A A Siddiqui
    Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Clin Infect Dis 33:1040-7. 2001
  5. ncbi Strongyloidiasis--the most neglected of the neglected tropical diseases?
    Annette Olsen
    DBL Centre for Health Research and Development, University of Copenhagen, Copenhagen, Denmark
    Trans R Soc Trop Med Hyg 103:967-72. 2009
  6. pmc Strongyloides stercoralis: there but not seen
    Martin Montes
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Curr Opin Infect Dis 23:500-4. 2010
  7. ncbi Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
    C S Lantz
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 392:90-3. 1998
  8. pmc Diagnosis, clinical features, and self-reported morbidity of Strongyloides stercoralis and hookworm infection in a Co-endemic setting
    Sören L Becker
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1292. 2011
  9. ncbi A modified agar plate method for detection of Strongyloides stercoralis
    K Koga
    Department of Parasitology, Gifu University School of Medicine, Japan
    Am J Trop Med Hyg 45:518-21. 1991
  10. pmc Seroepidemiology of strongyloidiasis in the Peruvian Amazon
    Pablo P Yori
    Asociacion Benefica PRISMA, Lima, Peru
    Am J Trop Med Hyg 74:97-102. 2006

Detail Information

Publications252 found, 100 shown here

  1. ncbi Strongyloides stercoralis: a field-based survey of mothers and their preschool children using ELISA, Baermann and Koga plate methods reveals low endemicity in western Uganda
    J R Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, Cromwell Road, London, UK
    J Helminthol 82:263-9. 2008
    To ascertain the current status of strongyloidiasis in mothers and their preschool children, a field-based survey was conducted in western Uganda using a combination of diagnostic methods: ELISA, Baermann concentration and Koga agar plate...
  2. pmc Strongyloidiasis in transplant patients
    Alison C Roxby
    Division of Allergy and Infectious Diseases, University of Washington, Seattle, USA
    Clin Infect Dis 49:1411-23. 2009
    ..but physicians in the United States often miss opportunities to identify patients with chronic strongyloidiasis. Screening tests have limitations, and clinical suspicion remains an important component of the evaluation ..
  3. pmc High throughput multiplex PCR and probe-based detection with Luminex beads for seven intestinal parasites
    Mami Taniuchi
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA22908, USA
    Am J Trop Med Hyg 84:332-7. 2011
    ..In conclusion, this multiplex PCR-bead protocol provides a sensitive diagnostic screen for a large panel of intestinal parasites...
  4. ncbi Diagnosis of Strongyloides stercoralis infection
    A A Siddiqui
    Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Clin Infect Dis 33:1040-7. 2001
    ..b>Strongyloidiasis is difficult to diagnose because the parasite load is low and the larval output is irregular...
  5. ncbi Strongyloidiasis--the most neglected of the neglected tropical diseases?
    Annette Olsen
    DBL Centre for Health Research and Development, University of Copenhagen, Copenhagen, Denmark
    Trans R Soc Trop Med Hyg 103:967-72. 2009
    ..stercoralis infections range from asymptomatic light infections to chronic symptomatic strongyloidiasis. Uncontrolled multiplication of the parasite (hyperinfection) and potentially life-threatening dissemination ..
  6. pmc Strongyloides stercoralis: there but not seen
    Martin Montes
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Curr Opin Infect Dis 23:500-4. 2010
    ..This review will highlight current published research on improved diagnostic methods for S. stercoralis and the immune mechanisms thought to be responsible for hyperinfection syndrome...
  7. ncbi Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
    C S Lantz
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 392:90-3. 1998
    ..These findings establish a role for IL-3 in immunity to parasites and indicate that one of the functions of IL-3 in host defence against infection is to expand populations of haematopoietic effector cells...
  8. pmc Diagnosis, clinical features, and self-reported morbidity of Strongyloides stercoralis and hookworm infection in a Co-endemic setting
    Sören L Becker
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1292. 2011
    ..Indeed, strongyloidiasis can be fatal, but only a few studies provide information regarding its health relevance in Africa...
  9. ncbi A modified agar plate method for detection of Strongyloides stercoralis
    K Koga
    Department of Parasitology, Gifu University School of Medicine, Japan
    Am J Trop Med Hyg 45:518-21. 1991
    The agar plate method is a new technique with high detection rates for coprological diagnosis of human strongyloidiasis. This report details modifications of the technique and establishes a standardized procedure...
  10. pmc Seroepidemiology of strongyloidiasis in the Peruvian Amazon
    Pablo P Yori
    Asociacion Benefica PRISMA, Lima, Peru
    Am J Trop Med Hyg 74:97-102. 2006
    ..b>Strongyloidiasis stercoralis was identified in the stool of 69 (8.7%) of 792 participants...
  11. pmc Factors affecting recovery of Strongyloides stercoralis larvae: an approach to a newly modified formalin-ether concentration technique for diagnosis of strongyloidiasis
    Witthaya Anamnart
    Department of Medical Technology, School of Allied Health Sciences and Public Health, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand
    J Clin Microbiol 48:97-100. 2010
    To improve the diagnosis efficiency of human strongyloidiasis by using formalin-ether concentration technique (FECT), the effects of various factors on the recovery rates of Strongyloides stercoralis larvae were comparatively evaluated...
  12. pmc Occurrence of Strongyloides stercoralis in Yunnan Province, China, and comparison of diagnostic methods
    Peter Steinmann
    Department of Public Health, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 1:e75. 2007
    ..We studied the local occurrence of S. stercoralis in a village in Yunnan province, China, and comparatively assessed the performance of different diagnostic methods...
  13. ncbi Not your typical strongyloides infection: a literature review and case study
    Elizabeth B Foreman
    Division of Community Internal Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
    South Med J 99:847-52. 2006
    Strongyloides hyperinfection syndrome is one of several clinical manifestations of strongyloidiasis and has a mortality rate exceeding 85%...
  14. ncbi Epidemiological aspects of strongyloidiasis in Brazil
    F M Paula
    Laboratório de Investigação Médica LIM 06, Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil
    Parasitology 138:1331-40. 2011
    ..The occurrence of strongyloidiasis in immunosuppressed individuals was 11·8% by parasitological methods and 19·5% using immunological methods...
  15. pmc Randomized clinical trial on ivermectin versus thiabendazole for the treatment of strongyloidiasis
    Zeno Bisoffi
    Centre for Tropical Diseases, S Cuore Hospital, Negrar Verona, Italy
    PLoS Negl Trop Dis 5:e1254. 2011
    b>Strongyloidiasis may cause a life-threatening disease in immunosuppressed patients. This can only be prevented by effective cure of chronic infections. Direct parasitologic exams are not sensitive enough to prove cure if negative...
  16. pmc Comparison of the quantitative formalin ethyl acetate concentration technique and agar plate culture for diagnosis of human strongyloidiasis
    P M Intapan
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    J Clin Microbiol 43:1932-3. 2005
    ..This study serves as a good reminder to those conducting stool exams about the sensitivity and specificity limitations of both techniques...
  17. pmc The laboratory diagnosis and follow up of strongyloidiasis: a systematic review
    Ana Requena-Méndez
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS Negl Trop Dis 7:e2002. 2013
    b>Strongyloidiasis is frequently under diagnosed since many infections remain asymptomatic and conventional diagnostic tests based on parasitological examination are not sufficiently sensitive...
  18. pmc Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis
    Rojelio Mejia
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Curr Opin Infect Dis 25:458-63. 2012
    This review discusses the latest approaches to the diagnosis and treatment of patients with strongyloidiasis, with an emphasis on infection in the immunocompromised host and the risk for disseminated strongyloidiasis.
  19. ncbi Disseminated Strongyloides stercoralis: hyperinfection during medical immunosuppression
    Amy Basile
    Department of Dermatology, St Joseph Mercy Hospital, Ypsilanti, Michigan, USA
    J Am Acad Dermatol 63:896-902. 2010
    ..Dermatologists should be aware of patient populations at risk for infection with S stercoralis and be able to make this diagnosis to initiate earlier treatment of hyperinfection and dissemination...
  20. ncbi Strongyloides hyperinfection syndrome: an emerging global infectious disease
    Luis A Marcos
    Internal Medicine Department, University of Texas Health Science, 6431 Fannin Street, Suite 1 150, Houston, TX 77030, USA
    Trans R Soc Trop Med Hyg 102:314-8. 2008
    ..HS is an example of an emerging tropical infection migrating to developed countries and requiring greater clinician awareness...
  21. ncbi Molecular diagnosis of Strongyloides stercoralis in faecal samples using real-time PCR
    Jaco J Verweij
    Leiden University Medical Center, Department of Parasitology, Postbus 9600, 2300 RC Leiden, The Netherlands
    Trans R Soc Trop Med Hyg 103:342-6. 2009
    ..stercoralis infections, with a two-fold increase in the detection rate as compared with the commonly used Baermann sedimentation method...
  22. pmc A pentaplex real-time polymerase chain reaction assay for detection of four species of soil-transmitted helminths
    Madihah Basuni
    Institute for Research in Molecular Medicine, Universiti Sains Malaysia USM, Penang, Malaysia
    Am J Trop Med Hyg 84:338-43. 2011
    ..05). In conclusion, the real-time PCR assay described in this study provides a specific and sensitive diagnostic tool for the detection of these four helminth species in epidemiological studies and monitoring of treatment programs...
  23. pmc Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo
    Nicolas A Gillet
    Section of Immunology, Wright Fleming Institute, Imperial College London, London, United Kingdom
    PLoS Pathog 9:e1003263. 2013
    ..HTLV-1 causes a neuroinflammatory disease and adult T-cell leukemia/lymphoma. Strongyloidiasis, a gastrointestinal infection by the helminth Strongyloides stercoralis, and Infective Dermatitis associated ..
  24. pmc Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial
    Peter Steinmann
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e322. 2008
    ....
  25. ncbi Treatment failure in intestinal strongyloidiasis: an indicator of HTLV-I infection
    Angelica Terashima
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Int J Infect Dis 6:28-30. 2002
    ..of severe strongyloides with HTLV-I is well known; however, the seroprevalence of HTLV-I in other groups with strongyloidiasis is still unknown...
  26. ncbi Distribution of human Oesophagostomum bifurcum, hookworm and Strongyloides stercoralis infections in northern Ghana
    L Yelifari
    Ministry of Health, Upper East Region, P O Box 48, Bolgatanga, Ghana
    Trans R Soc Trop Med Hyg 99:32-8. 2005
    ..Spatial analysis of the prevalence data indicated that the endemic area is relatively clearly demarcated to the south of the study area...
  27. ncbi Strongyloidiasis: a review of the evidence for Australian practitioners
    Fay H Johnston
    Centre for Remote Health, Northern Territory, Australia
    Aust J Rural Health 13:247-54. 2005
    To summarise the available evidence concerning the prevalence, clinical manifestations, diagnosis and management of strongyloidiasis in Northern Australia.
  28. ncbi Treatment strategies in controlling strongyloidiasis
    Masao Satoh
    Department of Allergy and Immunology, Saitama Medical School, Moroyama, Iruma gun, Japan
    Expert Opin Pharmacother 5:2293-301. 2004
    b>Strongyloidiasis is an intestinal parasite infection caused by Strongyloides stercoralis. Spontaneous cure cannot be expected due to the unique life cycle of the parasite, termed autoinfection...
  29. ncbi The value of an immunoenzymatic test (enzyme-linked immunosorbent assay) for the diagnosis of strongyloidiasis in patients immunosuppressed by hematologic malignancies
    R Schaffel
    Hematology Service, Department of Internal Medicine, and Clinical Pathology Service, University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Am J Trop Med Hyg 65:346-50. 2001
    The diagnosis of strongyloidiasis relies upon the identification of the parasite in stool samples. In 1981, a serologic assay was developed, which was useful in the diagnosis of strongyloidiasis in the immunocompetent host...
  30. ncbi Chronic Strongyloides stercoralis infection in former British Far East prisoners of war
    G V Gill
    Department of Tropical Medicine, Liverpool School of Tropical Medicine, Liverpool L3 5QA
    QJM 97:789-95. 2004
    ..Under conditions of immunosuppression (particularly systemic corticosteroid treatment) potentially fatal dissemination of larvae ('hyperinfection') may occur...
  31. pmc Strongyloidiasis: an emerging infectious disease in China
    Chunmei Wang
    Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher Institutes, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, China
    Am J Trop Med Hyg 88:420-5. 2013
    Since the first case of strongyloidiasis reported in China in 1973, there have been 330 confirmed cases as of 2011...
  32. ncbi Strongyloidiasis: a diagnosis more common than we think
    Charles Philip Koczka
    Department of Gastroenterology and Hepatology, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York, USA
    Eur J Gastroenterol Hepatol 24:860-2. 2012
    ..We report a case series of strongyloidiasis in our urban medical center in New York City...
  33. pmc Severe strongyloidiasis: a systematic review of case reports
    Dora Buonfrate
    Centre for Tropical Diseases CTD, Sacro Cuore Hospital, Negrar, Verona, Italy
    BMC Infect Dis 13:78. 2013
    b>Strongyloidiasis is commonly a clinically unapparent, chronic infection, but immuno suppressed subjects can develop fatal disease...
  34. pmc Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen
    Martin Montes
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    PLoS Negl Trop Dis 3:e456. 2009
    Human strongyloidiasis varies from a chronic but limited infection in normal hosts to hyperinfection in patients treated with corticosteroids or with HTLV-1 co-infection. Regulatory T cells dampen immune responses to infections...
  35. pmc A coproantigen diagnostic test for Strongyloides infection
    Alex M Sykes
    Clinical Tropical Medicine Laboratory, Queensland Institute of Medical Research, University of Queensland, Herston, Australia
    PLoS Negl Trop Dis 5:e955. 2011
    ..These results indicate that diagnosis of human strongyloidiasis by detection of coproantigen is an approach worthy of further development.
  36. pmc Improved diagnosis of Strongyloides stercoralis using recombinant antigen-based serologies in a community-wide study in northern Argentina
    Alejandro J Krolewiecki
    Area de Investigaciones Clinicas, Fundacion Huesped, Pje Peluffo 3932, Buenos Aires, Argentina
    Clin Vaccine Immunol 17:1624-30. 2010
    ..NIE-LIPS compares favorably against the current CrAg-ELISA and stool evaluation, providing additional accuracy and ease of performance in the serodiagnosis of S. stercoralis infections irrespective of disease prevalence...
  37. ncbi Efficacy and safety of ivermectin and thiabendazole in the treatment of strongyloidiasis
    Rafael Igual-Adell
    Department of Microbiology, F Borja Hospital, Gandia
    Expert Opin Pharmacother 5:2615-9. 2004
    Treatment of strongyloidiasis has been traditionally based on thiabendazole, despite its frequent gastrointestinal side effects and failure to achieve eradication of the parasite from faeces in approximately 30% of cases...
  38. ncbi Prevalence of strongyloides in Northern Thailand and treatment with ivermectin vs albendazole
    Ponganant Nontasut
    Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 36:442-4. 2005
    ..1%, intestinal fluke 0.1%. Treatment with ivermectin 78 cases and albendazole 33 cases of strongyloidiasis gave cure rates at 98.7% and 78.7%, respectively...
  39. ncbi High prevalence of Strongyloides stercoralis among school children in rural Côte d'Ivoire
    Dominik Glinz
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    J Parasitol 96:431-3. 2010
    ..yet an important parasite from a public health perspective, surveys should consider the use of appropriate diagnostic methods to further our understanding of the epidemiology of strongyloidiasis and to better target control interventions.
  40. ncbi Human T-lymphotropic virus 1: recent knowledge about an ancient infection
    Kristien Verdonck
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Lancet Infect Dis 7:266-81. 2007
    ..The understanding of the interaction between virus and host response has improved markedly, but there are still no clear surrogate markers for prognosis and there are few treatment options...
  41. ncbi Novel real-time PCR for the universal detection of Strongyloides species
    Stefanie Kramme
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Med Microbiol 60:454-8. 2011
    b>Strongyloidiasis is a neglected disease that is prevalent mainly in tropical and subtropical regions. It is caused by intestinal nematodes of the genus Strongyloides...
  42. ncbi An in vitro larval motility assay to determine anthelmintic sensitivity for human hookworm and Strongyloides species
    A C Kotze
    Commonwealth Scientific and Industrial Research Organisation Livestock Industries, St Lucia, Queensland 4067, Australia
    Am J Trop Med Hyg 71:608-16. 2004
    ....
  43. ncbi Intestinal strongyloidiasis: recognition, management, and determinants of outcome
    Ronald Concha
    Division of Internal Medicine, University of Miami, 8501 SW 87th Court, Miami, FL 33173 4552, USA
    J Clin Gastroenterol 39:203-11. 2005
    ..increase the risk for the occurrence of symptomatic intestinal hyperinfection and/or often-fatal disseminated strongyloidiasis have been better defined...
  44. pmc Use of enzyme-linked immunosorbent assay and dipstick assay for detection of Strongyloides stercoralis infection in humans
    H Rogier van Doorn
    Department of Medical Microbiology, Academic Medical Center, Room L1 245, P O Box 22660, 1100DD Amsterdam, The Netherlands
    J Clin Microbiol 45:438-42. 2007
    ..and Bordier-ELISA [Bordier Affinity Products SA]) for their use in the serodiagnosis of imported strongyloidiasis. Both commercially available ELISAs have not been evaluated previously...
  45. ncbi Epidemiology of Strongyloides stercoralis in north-east Thailand: application of the agar plate culture technique compared with the enzyme-linked immunosorbent assay
    Paiboon Sithithaworn
    Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Trans R Soc Trop Med Hyg 97:398-402. 2003
    ..1%) by conventional optical density (OD)-based ELISA. Taking APCT as the reference method for diagnosis of strongyloidiasis, the sensitivity and specificity of the OD-based ELISA were 65% and 81...
  46. pmc An unusual cause of alveolar hemorrhage post hematopoietic stem cell transplantation: a case report
    Sachin Gupta
    Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 6:87. 2006
    ..Diffuse alveolar hemorrhage associated with Strongyloides stercoralis hyperinfection in stem cell transplant patients has been rarely reported...
  47. ncbi Subcutaneous ivermectin as a safe salvage therapy in Strongyloides stercoralis hyperinfection syndrome: a case report
    Jerome Pacanowski
    Départements de Microbiologie, Soins Intensifs de Pneumologie, et d Oncologie Médicale, Hopital Europeen Georges Pompidou, Assistance Publique des Hopitaux de Paris, Pairs, France
    Am J Trop Med Hyg 73:122-4. 2005
    ..stercoralis hyperinfection syndrome who was unresponsive to an oral combination of ivermectin and albendazole...
  48. ncbi Parasites (filaria & strongyloides) in malignant pleural effusion
    Prashant L Patil
    Indian J Med Sci 59:455-6. 2005
  49. ncbi Severe strongyloidiasis in corticosteroid-treated patients: case series and literature review
    Laurence Fardet
    Hopital Saint Antoine, Internal Medicine, Parasitology and Intensive Care Department, 184 rue du Fbg Saint Antoine, 75012 Paris, France
    J Infect 54:18-27. 2007
    To describe the main features of severe strongyloidiasis in corticosteroid-treated patients
  50. ncbi Diagnosis of Strongyloides stercoralis in a peritoneal effusion from an HIV-seropositive man. A case report
    In S Hong
    Department of Pathology, College of Medicine, Howard University, 520 W Street, N W, Washington, D C 20059, USA
    Acta Cytol 48:211-4. 2004
    ..becomes immunocompromised, autoinfection may increase the intestinal worm burden and lead to disseminated strongyloidiasis. The parthenogenetic adult female larvae can remain embedded in the mucosa of the small intestine for years, ..
  51. ncbi Intraepithelial infiltration of eosinophils and their contribution to the elimination of adult intestinal nematode, Strongyloides venezuelensis in mice
    Mohamed El-Malky
    Department of Molecular Parasitology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho, Nagoya 467 8601, Japan
    Parasitol Int 52:71-9. 2003
    ..The present study suggests that eosinophils are capable of attacking adult nematodes in the intestinal epithelia, probably in conjunction with secretory IgA, although they are not enough for the complete worm expulsion...
  52. ncbi Unsuspected strongyloidiasis in hospitalised elderly patients with and without eosinophilia
    M Pirisi
    Department of Medical Sciences, University of Eastern Piedmont Amedeo Avogadro, Novara, Italy
    Clin Microbiol Infect 12:787-92. 2006
    The prevalence and associated factors of chronic uncomplicated strongyloidiasis were estimated among 200 consecutive elderly patients (aged >or= 60 years) admitted to a general hospital in northern Italy...
  53. ncbi Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis
    Eleuza R Machado
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    J Immunol 175:3892-9. 2005
    ....
  54. pmc Maltreatment of Strongyloides infection: case series and worldwide physicians-in-training survey
    David R Boulware
    Division of Infectious Disease and International Medicine, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
    Am J Med 120:545.e1-8. 2007
    b>Strongyloidiasis infects hundreds of millions of people worldwide and is an important cause of mortality from intestinal helminth infection in developed countries...
  55. ncbi Counterregulation of Th2 immunity by interleukin 12 reduces host defenses against Strongyloides venezuelensis infection
    Eleuza R Machado
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo USP, Sao Paulo, Brazil
    Microbes Infect 11:571-8. 2009
    ..Together, our results showed that the absence of IL-12 upregulates the Th2 immune response, which is important for control of S. venezuelensis infection...
  56. ncbi Eosinophilia and the seroprevalence of schistosomiasis and strongyloidiasis in newly arrived pediatric refugees: an examination of Centers for Disease Control and Prevention screening guidelines
    Elizabeth E Dawson-Hahn
    Department of Pediatrics, Hasbro Children s Hospital, Providence, RI, USA
    J Pediatr 156:1016-8, 1018.e1. 2010
    ..recommend examination of the absolute eosinophil count (AEC) to screen for asymptomatic schistosomiasis and strongyloidiasis. We examined the predictive validity of an AEC >400 cells/microL to identify refugees with serologic ..
  57. ncbi Endemic strongyloidiasis on the Spanish Mediterranean coast
    P R Sánchez
    Department of Internal Medicine, Requena General Hospital, Valencia, Spain
    QJM 94:357-63. 2001
    ..We describe the epidemiology and clinical features of 152 prospectively identified cases of strongyloidiasis in an European region, and identify risk factors for the development of severe forms of the disease...
  58. ncbi Hydrophobic fractions from Strongyloides venezuelensis for use in the human immunodiagnosis of strongyloidiasis
    Nagilla Daliane Feliciano
    Department of Immunology, Microbiology and Parasitology, Institute of Biomedical Sciences, Federal University of Uberlandia, 38400 902, Uberlandia, Minas Gerais, Brazil
    Diagn Microbiol Infect Dis 67:153-61. 2010
    ..and aqueous phases of total saline (TS) and alkaline extracts of Strongyloides venezuelensis for human strongyloidiasis immunodiagnosis...
  59. ncbi IgG avidity in differential serodiagnosis of human strongyloidiasis active infection
    Henrique T Gonzaga
    Departamento de Imunologia, Microbiologia e Parasitologia, Instituto de Ciencias Biomedicas, Universidade Federal de Uberlandia, Av Para 1720, 38400 902, Uberlandia, MG, Brazil
    Immunol Lett 139:87-92. 2011
    ..avidity assays have been developed for several parasitic diseases although there are no researches focused in strongyloidiasis diagnosis...
  60. pmc High rate of strongyloidosis infection, out of endemic area, in patients with eosinophilia and without risk of exogenous reinfections
    Silvia A Repetto
    Departamento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires
    Am J Trop Med Hyg 82:1088-93. 2010
    ..stercoralis infection to prevent disseminated infections secondary to corticoid therapy...
  61. ncbi Strongyloides stercoralis hyperinfection: difficulties in diagnosis and treatment
    N M Feely
    Department of Anaesthetics, Wycombe Hospital, High Wycombe, Buckinghamshire, UK
    Anaesthesia 65:298-301. 2010
    ..Once the diagnosis of strongyloidiasis was made, the patient was successfully treated with subcutaneous antihelminthic drugs...
  62. ncbi The crucial role of granulocytes in the early host defense against Strongyloides ratti infection in mice
    K Watanabe
    Department of Parasitology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Parasitol Res 86:188-93. 2000
    ..ratti adult worms (e.g. number of intestinal mucosal mast cells, time of worm expulsion). These results suggest that granulocytes are mainly involved in the host early defense against parasites...
  63. ncbi Invasive enteritis by Strongyloides stercoralis presenting as acute abdominal distress under corticosteroid therapy
    M A Rodrigues
    Division of Gastroenterology, Botucatu Medical School, , Brazil
    Rev Hosp Clin Fac Med Sao Paulo 56:103-6. 2001
    ..We report a case of invasive intestinal strongyloidiasis that was clinically expressed as acute abdominal distress in a 73-year-old man from São Paulo who had been ..
  64. ncbi Hyper-variable regions in 18S rDNA of Strongyloides spp. as markers for species-specific diagnosis
    Hideo Hasegawa
    Department of Biology, Faculty of Medicine, and Institute of Scientific Research, Oita University, Hasama, Yufu, Oita 879 5593, Japan
    Parasitol Res 104:869-74. 2009
    ....
  65. ncbi Efficacy of parasitological methods for the diagnosis of Strongyloides stercoralis and hookworm in faecal specimens
    Elizabete de J Inês
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, Universidade Federal da Bahia, Salvador, Brazil
    Acta Trop 120:206-10. 2011
    ..6%, 28.4% and 23% of samples, respectively when re-examined by the APC. As a definitive diagnosis of strongyloidiasis depends on the microscopic demonstration of parasites, increasing the sensitivity of the detection requires ..
  66. ncbi Minimal change nephrotic syndrome in association with strongyloidiasis
    Y P Hsieh
    Division of Nephrology, Department of Medicine, Changhua Christian Hospital, Changhua, Taiwan
    Clin Nephrol 66:459-63. 2006
    ..Although parasitic infections have been known to be associated with immune complex-mediated glomerular lesions, strongyloidiasis-related glomerulopathy has not been well documented...
  67. ncbi Strongyloides stercoralis hyperinfection presenting with symptoms mimicking acute exacerbation of chronic obstructive pulmonary disease
    Hsu Chung Liu
    Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, R O C
    J Chin Med Assoc 72:442-5. 2009
    ..We suggest that a screening test be done for patients who live in endemic areas and those who are going to receive steroids for chronic disease...
  68. ncbi Soil-transmitted helminthiases and health behaviors among schoolchildren and community members in a west-central border area of Thailand
    Malinee T Anantaphruti
    Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 35:260-6. 2004
    ..Examination of the health behavior of the study samples showed that approximately 75% always defecated in a toilet. Schoolchildren who always wore shoes comprised 67%, which was lower than the community, at 85%...
  69. ncbi Gelatin particle indirect agglutination and enzyme-linked immunosorbent assay for diagnosis of strongyloidiasis using Strongyloides venezuelensis antigen
    Maria Cecilia Huaman
    Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan
    Trans R Soc Trop Med Hyg 97:535-8. 2003
    Routine microscopical examination of stool specimens for diagnosis of strongyloidiasis is insensitive and serological methods using Strongyloides stercoralis antigen are at present not available for field studies...
  70. ncbi Minimal change nephrotic syndrome in a patient with strongyloidiasis
    Mieko Miyazaki
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Clin Exp Nephrol 14:367-71. 2010
    b>Strongyloidiasis, a chronic infection caused by the intestinal parasite Strongyloides stercoralis, is prevalent in the Nansei Islands of Japan...
  71. ncbi Intestinal strongyloidiasis: a diagnosis frequently missed in the tropics
    Vinita Agrawal
    Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India
    Trans R Soc Trop Med Hyg 103:242-6. 2009
    ..The initial stool examination and peripheral blood eosinophil count were normal in all patients. Strongyloidiasis was not suspected clinically in any patient and the diagnosis was achieved on endoscopic biopsy...
  72. ncbi A simple modification of the Baermann method for diagnosis of strongyloidiasis
    F Hernández-Chavarría
    Unidad de Microscopia Electrónica y Facultad de Microbiología, Universidad de Costa Rica, San Jose, Costa Rica
    Mem Inst Oswaldo Cruz 96:805-7. 2001
    ..Data obtained by the modified Baermann method suggest that this methodology may helps concentrate larvae of S. stercoralis as efficiently as the original method...
  73. ncbi Cutaneous Strongyloides stercoralis infection: an unusual presentation
    Micki N Ly
    Ohio State University, OH, USA
    J Am Acad Dermatol 49:S157-60. 2003
    ..Human beings contract strongyloidiasis by penetration of filariform larvae into the skin or mucous membrane after contact with contaminated soil...
  74. ncbi Fatal disseminated strongyloidiasis in patients on immunosuppressive therapy: report of two cases
    I S Reddy
    Department of Dermatology, Apollo Hospital, Hyderabad, India
    Indian J Dermatol Venereol Leprol 71:38-40. 2005
    Disseminated strongyloidiasis is a rare manifestation in patients on immunosuppressive drugs. We report two cases of fatal disseminated Strongyloides stercoralis infestation...
  75. ncbi Field survey for strongyloidiasis in eastern Uganda with observations on efficacy of preventive chemotherapy and co-occurrence of soil-transmitted helminthiasis/intestinal schistosomiasis
    J C Sousa-Figueiredo
    WHO Collaborating Centre Schistosomiasis, Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, United Kingdom
    J Helminthol 85:325-33. 2011
    Following our previous field surveys for strongyloidiasis in western Uganda, 120 mothers and 232 children from four villages in eastern Uganda were examined, with two subsequent investigative follow-ups...
  76. ncbi [Infection due to Strongyloides stercoralis: epidemiological, clinical, diagnosis findings and outcome in 30 patients]
    Marcelo Corti
    Hospital de Enfermedades Infecciosas Francisco J Muñiz, Buenos Aires, Argentina
    Rev Chilena Infectol 28:217-22. 2011
    ..Infection usually remains asymptomatic, but in immunocompromised hosts severe and life-threatening manifestations such as hyperinfection syndrome and disseminated disease might occur...
  77. ncbi Clinical and epidemiological features of 33 imported Strongyloides stercoralis infections
    Ana Gonzalez
    Barcelona Centre for International Health Research CRESIB, CIBERESP, Hospital Clinic, C Rossello 132, 4 degrees, 08036 Barcelona, Spain
    Trans R Soc Trop Med Hyg 104:613-6. 2010
    ..Strongyloides stercoralis infection should be considered in immigrants and travellers with eosinophilia or compatible symptoms coming from endemic areas. Diagnosis should always be sought in immunocompromised hosts...
  78. ncbi Proteomic analysis of Strongyloides stercoralis L3 larvae
    A Marcilla
    Area de Parasitología, Departament de Biologia Cellular i Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain
    Parasitology 137:1577-83. 2010
    b>Strongyloidiasis can be perpetuated by autoinfection with the filariform larvae L3, causing asymptomatic chronic infections and creating a population of carriers, affecting not only developing countries...
  79. ncbi Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7-day high-dose albendazole for chronic strongyloidiasis
    Yupin Suputtamongkol
    Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Int J Antimicrob Agents 31:46-9. 2008
    ..a single oral dose of the parenteral veterinary preparation of ivermectin in 42 Thai patients with chronic strongyloidiasis (21 in each group)...
  80. pmc Strongyloides ratti: in vitro and in vivo activity of tribendimidine
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e136. 2008
    b>Strongyloidiasis is a truly neglected tropical disease, but its public health significance is far from being negligible. At present, only a few drugs are available for the treatment and control of strongyloidiasis.
  81. pmc The cost-effectiveness of ivermectin vs. albendazole in the presumptive treatment of strongyloidiasis in immigrants to the United States
    P Muennig
    Department of Health Policy and Management, Mailman School of Public Health, Columbia University, NY 10032, USA
    Epidemiol Infect 132:1055-63. 2004
    ..Any presumptive treatment strategy is cost-effective when compared with most common medical interventions...
  82. ncbi Utility of serological follow-up of chronic strongyloidiasis after anthelminthic chemotherapy
    Wendy A Page
    Miwatj Health Aboriginal Corporation, P O Box 519, Nhulunbuy, Northern Territory, 0881, Australia
    Trans R Soc Trop Med Hyg 100:1056-62. 2006
    The difficulty of establishing a diagnosis and confirming cure of strongyloidiasis is widely appreciated. As parasitological diagnosis is often unsatisfactory, serodiagnosis is frequently relied upon...
  83. ncbi Efficacy of ivermectin for chronic strongyloidiasis: two single doses given 2 weeks apart
    Osamu Zaha
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Infect Chemother 8:94-8. 2002
    We assessed the efficacy and adverse effects of ivermectin for the treatment of chronic strongyloidiasis. Fifty patients were treated with a single dose of ivermectin at approximately 200 microg/kg, and the dose was repeated 2 weeks later...
  84. ncbi Clinical presentation and diagnostic sensitivity of laboratory tests for Strongyloides stercoralis in travellers compared with immigrants in a non-endemic country
    Sonali Sudarshi
    The Hospital for Tropical Diseases, London, UK
    Trop Med Int Health 8:728-32. 2003
    ..To assess whether the clinical and laboratory methods for diagnosing Strongyloides stercoralis infection in non-endemic countries is different between those who are chronically exposed and those who travel...
  85. ncbi Comparative studies on the efficacy of three anthelminthics on treatment of human strongyloidiasis in Okinawa, Japan
    H Toma
    Department of Parasitology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Southeast Asian J Trop Med Public Health 31:147-51. 2000
    A study was undertaken to compare the efficacy of three drugs in the treatment of uncomplicated strongyloidiasis in Okinawa, Japan...
  86. pmc Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice
    Ann Marie Galioto
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th St, BLSB 530, Philadelphia, PA 19107, USA
    Infect Immun 74:5730-8. 2006
    ..stercoralis in mice...
  87. pmc Efficacy and safety of single and double doses of ivermectin versus 7-day high dose albendazole for chronic strongyloidiasis
    Yupin Suputtamongkol
    Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 5:e1044. 2011
    b>Strongyloidiasis, caused by an intestinal helminth Strongyloides stercoralis, is common throughout the tropics...
  88. ncbi Disseminated strongyloidiasis in immunocompromised patients--report of three cases
    Ricardo Galimberti
    Department of Dermatology and School of Medicine, Hospital Italiano, Buenos Aires, Argentina
    Int J Dermatol 48:975-8. 2009
    Strongyloides stercoralis is an intestinal nematode of humans. The characteristic cutaneous manifestation of strongyloidiasis is larva currens...
  89. pmc IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity
    Yuki Sasaki
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    J Exp Med 202:607-16. 2005
    ..Neutralization of IL-18 and IL-2 further reduces expulsion in infected STAT6(-/-) mice. These results suggest that collaboration between IL-18-dependent and Th2 cell-dependent mastocytosis is important for prompt parasite expulsion...
  90. ncbi Strongyloidiasis in an HIV-1-infected patient after highly active antiretroviral therapy-induced immune restoration
    Massimiliano Lanzafame
    J Infect Dis 191:1027. 2005
  91. ncbi Impairment of host immune response against strongyloides stercoralis by human T cell lymphotropic virus type 1 infection
    Tetsuo Hirata
    Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Am J Trop Med Hyg 74:246-9. 2006
    A large-scale study was undertaken to clarify the prevalence rate of strongyloidiasis in Okinawa, Japan and to evaluate the relationship between strongyloidiasis and infection with human T cell lymphotropic virus type 1 (HTLV-1)...
  92. pmc Strongyloides stercoralis in the Immunocompromised Population
    Paul B Keiser
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Microbiol Rev 17:208-17. 2004
    ....
  93. pmc Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice
    Udaikumar M Padigel
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    J Infect Dis 196:1844-51. 2007
    ..These experiments demonstrate that eosinophils function as antigen-presenting cells for the induction of the primary and the expansion of the secondary Th2 immune responses to S. stercoralis in mice...
  94. ncbi Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area
    Mona R Loutfy
    Department of Medicine, University of Toronto, Ontario, Canada
    Am J Trop Med Hyg 66:749-52. 2002
    b>Strongyloidiasis is a chronic infection that may result in significant morbidity; however, diagnosis and management remain problematic...
  95. ncbi Strongyloidiasis in a high risk community of Dhaka, Bangladesh
    Yasmin Sultana
    Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, Westmead, NSW, Australia
    Trans R Soc Trop Med Hyg 106:756-62. 2012
    ..stercoralis infection or socio demographic factors. This study confirms that squatters in this slum community in Dhaka have a high prevalence of S. stercoralis infection identified both by serological and coprological methods...
  96. ncbi Fatal meningoencephalitis caused by disseminated strongyloidiasis
    Hsien Hsueh Chiu
    Department of Chinese Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Acta Neurol Taiwan 14:24-7. 2005
    ..The eosinophilia and repeated stool examinations helped us to make the diagnosis of disseminated strongyloidiasis. In this patient the initial bacterial meningitis was followed by S. stercoralis hyperinfection...
  97. pmc Albendazole stimulates the excretion of strongyloides stercoralis Larvae in stool specimens and enhances sensitivity for diagnosis of strongyloidiasis
    Witthaya Anamnart
    Department of Medical Technology, School of Allied Health Sciences and Public Health, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand
    J Clin Microbiol 48:4216-20. 2010
    ..of Strongyloides stercoralis larvae in stool by oral administration of a single dose of 400 mg albendazole to strongyloidiasis patients. This result overcame the false-negative results of stool examination due to low larval numbers...
  98. ncbi Strongyloidiasis hyperinfection in a patient with membranoproliferative glomerulonephritis
    Pragati A Sathe
    Department of Pathology, Seth G S Medical College, Parel, Mumbai 400012, India
    J Postgrad Med 52:221-2. 2006
  99. ncbi Strongyloidiasis pre and post autologous peripheral blood stem cell transplantation
    H Orlent
    Department of Haematology, Academisch Ziekenhuis Rotterdam, Dijkzigt, The Netherlands
    Bone Marrow Transplant 32:115-7. 2003
    ..We describe two cases of patients transplanted with chronic strongyloidiasis. In one case eradication therapy was given prior to the transplant which was uncomplicated...
  100. ncbi [Immunodiagnosis of Strongyloides stercoralis infections in Chile using ELISA test]
    Ruben Mercado
    Unidad de Parasitología Norte, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 9183, Santiago, Chile
    Rev Med Chil 130:1358-64. 2002
    ..In immunocompromised patients, a disseminated disease may appear, sometimes fatal. In Chile, there is little epidemiological information about S stercoralis infections and appropriate diagnostic techniques are usually not used...
  101. ncbi Colonoscopic findings and pathologic characteristics of Strongyloides colitis: a case series
    Hideki Minematsu
    Gastroenterology Unit, Tomishiro Central Hospital, Tomigusuku, Japan
    Digestion 83:210-4. 2011
    b>Strongyloidiasis, which is caused by Strongyloides stercoralis, is one of the prevalent infections in the tropical and subtropical regions worldwide...

Research Grants14

  1. Mechanisms and Treatment of Chronic, Latent Human Strongyloidiasis
    James B Lok; Fiscal Year: 2013
    ..In its uncomplicated form, human strongyloidiasis results in chronic enteritis, diarrhea and failure to thrive in children, a syndrome common to other soil-..
  2. Immunological response, Viral Factors and Helminth Infections in Disease Expressi
    Edgar M Carvalho; Fiscal Year: 2012
    ..changes that increase the susceptibility of HTLV-1 infected subjects to development of disseminated strongyloidiasis. More recently, under the support of an R03 "Immunological Response and Disease Expression in HTLV-1" awarded ..
  3. Human Strongyloidiasis: Model Development
    James B Lok; Fiscal Year: 2012
    ....
  4. Insulin-like Signaling in Parasitic Nematode Development
    James B Lok; Fiscal Year: 2013
    ..clear adult worm infections and/or block fulminant autoinfection, a potentially fatal complication of human strongyloidiasis. These experiments will directly reflect the potential of DAF-12 NHR function as a chemotherapeutic target in ..
  5. IMMUNOREGULATION IN HUMAN STRONGYLOIDIASIS
    Martin Montes; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Strongyloidiasis is a significant medical problem in Peru...
  6. ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
    David Abraham; Fiscal Year: 2005
    ..stercoralis and in addition we will determine the role of these cells in the transition from the innate to the adaptive immune response to this infection. ..
  7. Interaction of HIV gp120 & G protein coupled receptors
    Lee Ratner; Fiscal Year: 2007
    ..abstract_text> ..
  8. HIV VPX/VPR STRUCTURE/FUNCTION
    Lee Ratner; Fiscal Year: 2001
    ..What are the roles of Vpr/x Interactive Cellular Proteins in HIV Infection? a. What is the role of li interaction with Vpx? b. Are there other Vpx- interactive proteins, and do they interact with Vpr? ..
  9. Chemo/Antiretroviral therapy for HTLV-1 ATLL
    Lee Ratner; Fiscal Year: 2005
    ..abstract_text> ..
  10. CHEMO/ANTIRETROVIRAL THERAPY FOR HTLV1 ATLL
    Lee Ratner; Fiscal Year: 2002
    ..abstract_text> ..
  11. HIV/SIV Vpx-Invariant chain Interaction
    Lee Ratner; Fiscal Year: 2004
    ..We will map the domains of SIVmac Vpx that are critical for nuclear localization and li interaction. Mutant SIVmac Vpx selectively missing each activity will then be studied by infection of rhesus macaques. ..
  12. HIV1 ASSEMBLY MECHANISM AND INHIBITION
    Lee Ratner; Fiscal Year: 2002
    ..In each case, they will examine the effects on membrane interactions and the structure and expression of extracellular virions, as well as identify the domains in Pr55gag that are critical for regulation by Vif or Vpu. ..
  13. Immunological Response and Disease Expression in HTLV-1
    Edgar Carvalho; Fiscal Year: 2006
    ..abstract_text> ..
  14. HTLV Receptor Identification and Characterization
    Lee Ratner; Fiscal Year: 2005
    ..Lastly, we will determine if the identified cDNA enhances HTLV-1 envelope binding to murine cell lines, and whether this allows HTLV replication and/or immortalization of murine T cells. ..