oropharyngeal neoplasms

Summary

Summary: Tumors or cancer of the OROPHARYNX.

Top Publications

  1. ncbi Oral sexual behaviors associated with prevalent oral human papillomavirus infection
    Gypsyamber D'Souza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Infect Dis 199:1263-9. 2009
  2. pmc Human papillomavirus and survival of patients with oropharyngeal cancer
    K Kian Ang
    University of Texas M D Anderson Cancer Center, Houston, USA
    N Engl J Med 363:24-35. 2010
  3. pmc Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    Anil K Chaturvedi
    National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Clin Oncol 29:4294-301. 2011
  4. ncbi Case-control study of human papillomavirus and oropharyngeal cancer
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    N Engl J Med 356:1944-56. 2007
  5. ncbi HPV-associated head and neck cancer: a virus-related cancer epidemic
    Shanthi Marur
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Lancet Oncol 11:781-9. 2010
  6. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
  7. pmc Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer
    Linda Marklund
    Department of Clinical Science, Intervention and Technology, Department of Oto Rhino Laryngology, Head and Neck Surgery, Karolinska University Hospital, Karolinska Institutet Stockholm, Sweden
    Cancer Med 1:82-8. 2012
  8. pmc EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Comprehensive Cancer Center Head and Neck Cancer Program, Ann Arbor, MI 48109, USA
    J Clin Oncol 26:3128-37. 2008
  9. ncbi Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma
    G Calais
    G Calais, Centre Hospitalier Universitaire Tours, France
    J Natl Cancer Inst 91:2081-6. 1999
  10. ncbi Trends in head and neck cancer incidence in Denmark, 1978-2007: focus on human papillomavirus associated sites
    Maria Blomberg
    Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 129:733-41. 2011

Detail Information

Publications257 found, 100 shown here

  1. ncbi Oral sexual behaviors associated with prevalent oral human papillomavirus infection
    Gypsyamber D'Souza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Infect Dis 199:1263-9. 2009
    ..046, for trend) or open-mouthed kissing partners (P = .023, for trend) but not vaginal sex partners. Oral sex and open-mouthed kissing are associated with the development of oral HPV infection...
  2. pmc Human papillomavirus and survival of patients with oropharyngeal cancer
    K Kian Ang
    University of Texas M D Anderson Cancer Center, Houston, USA
    N Engl J Med 363:24-35. 2010
    ..Oropharyngeal squamous-cell carcinomas caused by human papillomavirus (HPV) are associated with favorable survival, but the independent prognostic significance of tumor HPV status remains unknown...
  3. pmc Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    Anil K Chaturvedi
    National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Clin Oncol 29:4294-301. 2011
    ..Recent increases in incidence and survival of oropharyngeal cancers in the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking...
  4. ncbi Case-control study of human papillomavirus and oropharyngeal cancer
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
    N Engl J Med 356:1944-56. 2007
    ..Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of oropharyngeal squamous-cell carcinoma, but epidemiologic data have been inconsistent...
  5. ncbi HPV-associated head and neck cancer: a virus-related cancer epidemic
    Shanthi Marur
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Lancet Oncol 11:781-9. 2010
    ....
  6. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
    ..Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx...
  7. pmc Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer
    Linda Marklund
    Department of Clinical Science, Intervention and Technology, Department of Oto Rhino Laryngology, Head and Neck Surgery, Karolinska University Hospital, Karolinska Institutet Stockholm, Sweden
    Cancer Med 1:82-8. 2012
    ..Our data highlight the diversity of head neck cancer sub-sites and the importance of taking OSCC sub-sites in consideration in future clinical trials and treatment...
  8. pmc EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Comprehensive Cancer Center Head and Neck Cancer Program, Ann Arbor, MI 48109, USA
    J Clin Oncol 26:3128-37. 2008
    ..To prospectively identify markers of response to therapy and outcome in an organ-sparing trial for advanced oropharyngeal cancer...
  9. ncbi Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma
    G Calais
    G Calais, Centre Hospitalier Universitaire Tours, France
    J Natl Cancer Inst 91:2081-6. 1999
    ..e., advanced oropharynx carcinoma)...
  10. ncbi Trends in head and neck cancer incidence in Denmark, 1978-2007: focus on human papillomavirus associated sites
    Maria Blomberg
    Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 129:733-41. 2011
    ..HPV16 is the type most often found in HNCs; thus, the recent introduction of vaccination against HPV may in the future prevent HPV-associated cancers of the head and neck...
  11. pmc Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial
    Danny Rischin
    Department of Medical Oncology, Peter MacCallum Cancer Centre, A Beckett St, Locked Bag No 1, Melbourne 8006, Australia
    J Clin Oncol 28:4142-8. 2010
    ..To determine the prognostic importance of p16 and human papillomavirus (HPV) in patients with oropharyngeal cancer treated on a phase III concurrent chemoradiotherapy trial...
  12. pmc Biomarkers of HPV in head and neck squamous cell carcinoma
    Caihua Liang
    Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA
    Cancer Res 72:5004-13. 2012
    ....
  13. ncbi High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma
    Lisa Licitra
    Head and Neck Cancer Medical Oncology Unit, Medical Statistics and Biometry, Department of Head and Neck Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Clin Oncol 24:5630-6. 2006
    ..To which extent the viral integration by itself, and/or the associated wild-type (wt) TP53 status, and/or a functional p16 contribute to prognosis is unclear...
  14. pmc Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination
    Andrew G Schache
    Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
    Clin Cancer Res 17:6262-71. 2011
    ..In clinical trials, HPV16 status is an essential inclusion or stratification parameter, highlighting the importance of accurate testing...
  15. ncbi Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers
    Elaine M Smith
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Int J Cancer 108:766-72. 2004
    ..An exfoliated oral cytology test for HPV was a significant predictor of HR types in the cancers, suggesting that an oral rinse may provide an early biomarker of infected tumors...
  16. pmc Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: response and survival positively associated with HPV16 copy number
    Francis P Worden
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 26:3138-46. 2008
    ..To test induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CRT) or surgery/radiotherapy (RT) for advanced oropharyngeal cancer and to assess the effect of human papilloma virus (HPV) on response and outcome...
  17. ncbi Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship
    Peter C Levendag
    Department of Radiation Oncology, Erasmus Medical Center Daniel den Hoed, Rotterdam, The Netherlands
    Radiother Oncol 85:64-73. 2007
    ..To assess the relationship between the radiation therapy (RT) dose received by the muscular components of the swallowing (sw) apparatus and - dysphagia related - quality of life (QoL) in oropharyngeal cancer...
  18. ncbi SmartArc-based volumetric modulated arc therapy for oropharyngeal cancer: a dosimetric comparison with both intensity-modulated radiation therapy and helical tomotherapy
    Stefania Clemente
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 80:1248-55. 2011
    ..To investigate the roles of volumetric modulated arc therapy with SmartArc (VMAT-S), intensity-modulated radiation therapy (IMRT), and helical tomotherapy (HT) for oropharyngeal cancer using a simultaneous integrated boost (SIB) approach...
  19. ncbi Refining the diagnosis of oropharyngeal squamous cell carcinoma using human papillomavirus testing
    Max Robinson
    School of Dental Sciences, Newcastle University, UK
    Oral Oncol 46:492-6. 2010
    ..Furthermore, the techniques employed are automated and are subject to stringent quality assurance measures; features that can deliver routine, accurate and cost effective HPV testing for oropharyngeal cancers...
  20. ncbi Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement
    Dana Holzinger
    Molecular Biology Laboratory, Department of Otolaryngology, Head and Neck Surgery, Heidelberg University, Heidelberg, Germany
    Cancer Res 72:4993-5003. 2012
    ..55, 95% CI, 0.29-1.08). In summary, our findings argued that viral load or RNA pattern analysis is better suited than p16(INK4a) expression to identify HPV16-driven tumors in OPSCC patient populations...
  21. ncbi Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma
    Wei Shi
    Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, 610 University Ave, Toronto, Ontario, Canada, M5G 2M9
    J Clin Oncol 27:6213-21. 2009
    ..We compared a quantitative real-time polymerase chain reaction (qRT-PCR) assay for HPV16 mRNA to a DNA in situ hybridization (ISH) method, and evaluated their significance for overall (OS) and disease-free (DFS) survival...
  22. ncbi Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer
    Niklas Reimers
    Department of Oto Rhino Laryngology, Head and Neck Surgery, University of Cologne, Germany
    Int J Cancer 120:1731-8. 2007
    ..HPV+/p16+ tumors tended to have decreased EGFR expression, but using both immunohistological markers has significant prognostic implications...
  23. ncbi Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience
    Ajit Auluck
    Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia
    Cancer 116:2635-44. 2010
    ..Little is known about the ethnic variation in incidence for these cancers. This study determined incidence rates of OCC and oropharyngeal cancer among South Asian, Chinese, and the general population in British Columbia, Canada...
  24. ncbi Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998-2003
    A Blythe Ryerson
    Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer 113:2901-9. 2008
    ..The objective of the current study was to describe the incidence rates of oropharyngeal and oral cavity cancers in the US with a focus on anatomic sites potentially associated with HPV infection...
  25. ncbi Oral and oropharyngeal cancer in The Netherlands between 1989 and 2006: Increasing incidence, but not in young adults
    Boudewijn J M Braakhuis
    Department of Otolaryngology Head Neck Surgery, VU University Medical Center, MB Amsterdam, The Netherlands
    Oral Oncol 45:e85-9. 2009
    ..The reason for the decreasing annual incidence rate at all sites observed for Dutch young adults remains to be explained...
  26. pmc Risk factors for cancer of the oral cavity and oro-pharynx in Cuba
    L F Garrote
    Instituto de Oncologia y Radiobiologia, Calle 29 y E Vedado, La Habana, 10400, Cuba
    Br J Cancer 85:46-54. 2001
    ..The fractions attributable to alcohol drinking (7%) and low fruit intake (11%) were more modest. Thus, decreases in cigarette and cigar smoking are at present the key to oral cancer prevention in Cuba...
  27. ncbi Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype
    Samir K El-Mofty
    Washington University School of Medicine, St Louis, MO 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:339-45. 2006
    ..It is concluded that NKCa of the tonsils and base of tongue is a distinct subtype of squamous cell carcinoma of the head and neck with high prevalence of HPV DNA and a characteristic immunophenotype...
  28. ncbi National prevalence of oral HPV infection and related risk factors in the U.S. adult population
    A E Sanders
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    Oral Dis 18:430-41. 2012
    ..The results also provide population data that help evaluate the likely public health benefits of prophylactic vaccination against oral HPV acquisition...
  29. ncbi A causal role for human papillomavirus in head and neck cancer
    M L Gillison
    Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Lancet 363:1488-9. 2004
  30. ncbi Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma
    Parul Sinha
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer 118:3519-30. 2012
    ..The role of ECS as a prognosticator and adjuvant therapy determinant in surgically resected, human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC), however, has never been determined...
  31. ncbi The increasing clinical relevance of human papillomavirus type 16 (HPV-16) infection in oropharyngeal cancer
    Richard Shaw
    School of Cancer Studies, University of Liverpool, Liverpool, UK
    Br J Oral Maxillofac Surg 49:423-9. 2011
    ....
  32. ncbi Tumor stage, human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: an Italian validation study
    R Granata
    Head and Neck Cancer Medical Oncology Unit, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Ann Oncol 23:1832-7. 2012
    ..Recently, three groups with different outcomes were identified based on HPV status, smoking history and tumor stage. Our objective was to validate this model using a single-institutional retrospective database...
  33. ncbi Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: a United States multicenter study
    Bruce H Haughey
    Department of Otolaryngology Head and Neck Surgery Washington University School of Medicine, St Louis, Missouri, USA
    Head Neck 33:1683-94. 2011
    ..Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma...
  34. ncbi The epidemic of HPV-associated oropharyngeal cancer is here: is it time to change our treatment paradigms?
    Erich M Sturgis
    Departments of Head and Neck Surgery, and Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas
    J Natl Compr Canc Netw 9:665-73. 2011
    ..However, data are currently insufficient to change treatment paradigms for HPV-associated oropharyngeal cancer outside of a closely monitored clinical trial...
  35. pmc Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices
    Pawadee Lohavanichbutr
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mail Stop M5 C800, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Arch Otolaryngol Head Neck Surg 135:180-8. 2009
    ..To study the difference in gene expression between human papillomavirus (HPV)-positive and HPV-negative oral cavity and oropharyngeal squamous cell carcinoma (OSCC)...
  36. ncbi Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study
    Rolando Herrero
    International Agency for Research on Cancer, Lyon, France rherrero amnet co cr
    J Natl Cancer Inst 95:1772-83. 2003
    ..To investigate these associations, we conducted a multicenter case-control study of cancer of the oral cavity and oropharynx in nine countries...
  37. ncbi Molecular classification identifies a subset of human papillomavirus--associated oropharyngeal cancers with favorable prognosis
    Paul M Weinberger
    Department of Medical Oncology, Yale University School of Medicine, New Haven, CT, USA
    J Clin Oncol 24:736-47. 2006
    ..Retinoblastoma (Rb) downregulation by HPV E7 results in p16 upregulation. We hypothesized that p16 overexpression in OSCC defines HPV-induced tumors with favorable prognosis...
  38. pmc Infiltrating lymphocytes and human papillomavirus-16--associated oropharyngeal cancer
    Derrick Wansom
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Laryngoscope 122:121-7. 2012
    ....
  39. pmc The epidemiology of oral HPV infection among a multinational sample of healthy men
    Aimee R Kreimer
    National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 20:172-82. 2011
    ..Oral human papillomavirus type-16 (HPV16) infection is a risk factor for oropharyngeal cancer. We examined oral HPV infection among healthy men...
  40. ncbi Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions
    Karina Braga Ribeiro
    International Agency for Research on Cancer, Lyon, France
    Int J Epidemiol 40:489-502. 2011
    ..We have evaluated the HPV deoxyribonucleic acid (DNA) prevalence as well as the association between serological response to HPV infection and HNSCC in two distinct populations from Central Europe (CE) and Latin America (LA)...
  41. ncbi An epidemic of oropharyngeal squamous cell carcinoma (OSCC) due to human papillomavirus (HPV) infection and aspects of treatment and prevention
    Torbjörn Ramqvist
    Department of Oncology Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    Anticancer Res 31:1515-9. 2011
    ..Finally, we suggest that the possibility to vaccinate against HPV-positive OSCC should be examined...
  42. ncbi Intensity-modulated radiation therapy for the treatment of oropharyngeal carcinoma: the Memorial Sloan-Kettering Cancer Center experience
    Fernando F de Arruda
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
    Int J Radiat Oncol Biol Phys 64:363-73. 2006
    ..To review the Memorial Sloan-Kettering Cancer Center's experience in using intensity-modulated radiation therapy (IMRT) for the treatment of oropharyngeal cancer...
  43. pmc p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 34:1088-96. 2010
    ..Many recommend use of both p16 immunohistochemistry and HPV in situ hybridization (ISH). A significant minority of tumors are p16 positive and HPV ISH negative, the significance of which is unclear...
  44. ncbi Rising incidence of oropharyngeal cancer and the role of oncogenic human papilloma virus
    Joel A Ernster
    Department of Otolaryngology Head and Neck Surgery, University of Colorado Health Sciences Center, Denver, CO 80909, USA
    Laryngoscope 117:2115-28. 2007
    ..To document the increasing incidence of oropharyngeal (OP) cancer and to provide evidence that this increase is caused by oncogenic human papilloma virus (HPV)...
  45. ncbi Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial
    M R Posner
    The Tisch Cancer Institute, Mount Sinai Medical Center, New York, NY, USA
    Ann Oncol 22:1071-7. 2011
    ..The association between human papillomavirus (HPV) and overall survival (OS) in oropharynx cancer (OPC) was retrospectively examined in TAX 324, a phase III trial of sequential therapy for locally advanced head and neck cancer...
  46. ncbi Incidence of oral and oropharyngeal cancer in United Kingdom (1990-1999) -- recent trends and regional variation
    D I Conway
    Dental Public Health Unit, Level 8, University of Glasgow Dental Hospital and School, 378 Sauchiehall Street, Glasgow G2 3JZ, UK
    Oral Oncol 42:586-92. 2006
    ..Incidence remains higher in men than women, in older compared with younger groups, and in northern regions. These findings provide evidence of a continuing increase in the burden of oral cancer across the UK...
  47. ncbi Intensity-modulated radiation therapy in head and neck cancers: an update
    Nancy Lee
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Head Neck 29:387-400. 2007
    ..The results do confirm that IMRT does decrease xerostomia compared with conventional radiotherapy...
  48. ncbi Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma
    Fabrice Denis
    Clinique d Oncologie et Radiothérapie, Hopital Bretonneau, 2 Blvd Tonnelé, 37044 Tours, France
    J Clin Oncol 22:69-76. 2004
    ....
  49. ncbi Function, postoperative morbidity, and quality of life after cervical sentinel node biopsy and after selective neck dissection
    Franziska Schiefke
    Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, University of Leipzig, Nürnberger Str 57, D 04103 Leipzig, Germany
    Head Neck 31:503-12. 2009
    ..It is claimed that SNB may be superior to selective neck dissection (SND) with respect to quality of life (QOL) and postoperative morbidity...
  50. pmc Human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy
    A M Hong
    Department of Radiation Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Building 27, Missenden Road, Camperdown, Sydney, New South Wales 2050, Australia
    Br J Cancer 103:1510-7. 2010
    ..This study examines the prognostic significance of human papillomavirus (HPV) in patients with locally advanced oropharyngeal squamous cell carcinoma (SCC) treated primarily with surgery or definitive radiotherapy...
  51. pmc p16 Immunohistochemistry as a standalone test for risk stratification in oropharyngeal squamous cell carcinoma
    James S Lewis
    Department of Pathology and Immunology, Washington University in St Louis, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Head Neck Pathol 6:S75-82. 2012
    ....
  52. ncbi The lip-splitting mandibulotomy: aesthetic and functional outcomes
    Peter T Dziegielewski
    Division of Otolaryngology Head and Neck Surgery, 1E4 University of Alberta Hospital, 8440 112 Street NW, Edmonton, Alberta, Canada T6G 2B7
    Oral Oncol 46:612-7. 2010
    ..05). The LSMA provides satisfactory scarring and low self-perception of disfigurement for patients. Moreover, the LSMA does not impact lower-lip sensation, movement or oral continence...
  53. ncbi Transoral robotic surgery for oropharyngeal carcinoma and its impact on patient-reported quality of life and function
    Fernando Danelon Leonhardt
    Department of Otorhinolaryngology Head and Neck Surgery, Federal University of Sao Paulo, Sao Paulo, Brazil
    Head Neck 34:146-54. 2012
    ..The aim of this study was to assess the quality of life of patients with oropharyngeal squamous cell carcinoma after transoral robotic surgery (TORS)...
  54. ncbi Using population-based cancer registry data to assess the burden of human papillomavirus-associated cancers in the United States: overview of methods
    Meg Watson
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer 113:2841-54. 2008
    ....
  55. ncbi Transoral robotic surgery and human papillomavirus status: Oncologic results
    Marc A Cohen
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Head Neck 33:573-80. 2011
    ..The purpose of this study was to assess HPV-related outcomes after transoral robotic surgery (TORS) with adjuvant therapy as indicated...
  56. pmc Validation of a novel diagnostic standard in HPV-positive oropharyngeal squamous cell carcinoma
    A G Schache
    Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, 3 01 Research Wing, Daulby Street, Liverpool L69 3GN, UK
    Br J Cancer 108:1332-9. 2013
    ..Recently, a novel RNA in situ hybridisation test (RNAscope) has been developed for the detection of HR-HPV in FFPE tissue; however, validation against the 'gold standard' has not been reported...
  57. pmc Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence
    Jessica H Maxwell
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 16:1226-35. 2010
    ....
  58. ncbi Difference in expression of EGFR, pAkt, and PTEN between oropharyngeal and oral cavity squamous cell carcinoma
    Hye Sung Won
    Division of Medical Oncology, Department of Internal Medicine, Uijeongbu St Mary s Hospital, College of Medicine, The Catholic University of Korea, Republic of Korea
    Oral Oncol 48:985-90. 2012
    ..The aims of this study were to evaluate the expression of EGFR, PI3K, Akt, mTOR, and PTEN in the oral cavity and oropharyngeal cancers, and to investigate their clinical significance as prognostic markers...
  59. ncbi Trends in the incidence of oral cavity and oropharyngeal cancers in Spain
    Dyego Leandro Bezerra de Souza
    Departamento de Microbiologia, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Espana
    Head Neck 34:649-54. 2012
    ..The purpose of this study was to analyze and compare incidence trends of oral cavity and oropharyngeal cancers, using data from population-based Spanish cancer registries...
  60. pmc Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors
    Jason T Rich
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Laryngoscope 119:1709-19. 2009
    ..Document survival, prognostic variables, and functional outcomes of patients with AJCC stage III or IV oropharyngeal cancer, treated with transoral laser microsurgery (TLM) +/- adjuvant therapy...
  61. ncbi p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx
    Federica Perrone
    Unit of Experimental Molecular Pathology, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 109:2461-5. 2007
    ..The TP53 polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing genetic defect...
  62. ncbi Human papillomavirus positive squamous cell carcinoma of the oropharynx: a radiosensitive subgroup of head and neck carcinoma
    K Lindel
    Department of Radiation Oncology, Inselspital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland
    Cancer 92:805-13. 2001
    ....
  63. ncbi Weekly low-dose docetaxel-based chemoradiotherapy for locally advanced oropharyngeal or hypopharyngeal carcinoma: a retrospective, single-institution study
    Junichi Fukada
    Department of Radiology, Keio University, School of Medicine, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 76:417-24. 2010
    ..To retrospectively assess the efficacy, toxicity, and prognostic factors of weekly low-dose docetaxel-based chemoradiotherapy for Stage III/IV oropharyngeal or hypopharyngeal carcinoma...
  64. ncbi Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy
    Pètra M Braam
    Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 66:975-80. 2006
    ..A Phase II study was conducted to determine the value of IMRT for salivary output preservation compared with conventional radiotherapy (CRT)...
  65. ncbi HPV16 semiquantitative viral load and serologic biomarkers in oral and oropharyngeal squamous cell carcinomas
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 115:329-32. 2005
    ....
  66. ncbi Locoregionally advanced carcinoma of the oropharynx: conventional radiotherapy vs. accelerated hyperfractionated radiotherapy vs. concomitant radiotherapy and chemotherapy--a multicenter randomized trial
    Patrizia Olmi
    Rep di Radioterapia, Dipartimento di Fisiopatologia Clinica, Universita, Firenze, Italy
    Int J Radiat Oncol Biol Phys 55:78-92. 2003
    ..split-course accelerated hyperfractionated RT (S-AHF), Arm B, vs. conventional fractionation RT plus concomitant chemotherapy (CT), Arm C, in terms of survival and toxicity for advanced, unresectable epidermoid tumors of oropharynx...
  67. ncbi Population-based analysis of oral and oropharyngeal carcinoma: changing trends of histopathologic differentiation, survival and patient demographics
    Vikas Mehta
    Department of Otolaryngology, The New York Eye and Ear Infirmary, New York, New York 10003, USA
    Laryngoscope 120:2203-12. 2010
    ..To test the hypothesis that decreased histologic differentiation and increased disease-specific survival is related to a decline in smoking rates and an increased percentage of human papillomavirus (HPV)-related tumors...
  68. ncbi Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a University of Pennsylvania Phase II Trial
    Mitchell Machtay
    Department of Radiation Oncology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Clin Oncol 20:3964-71. 2002
    ..To determine the efficacy, feasibility, and toxicity of a new regimen for locally advanced oropharyngeal carcinoma...
  69. ncbi Intensity-modulated chemoradiation for treatment of stage III and IV oropharyngeal carcinoma: the University of California-San Francisco experience
    Kim Huang
    Department of Radiation Oncology, University of California San Francisco, San Francisco, California 94143 0226, USA
    Cancer 113:497-507. 2008
    ..Treatment outcomes for stage III and IV oropharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) and concurrent chemotherapy without prior surgical resection were reviewed...
  70. ncbi Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden
    Bengt Göran Hansson
    Department of Laboratory Medicine, Section of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    Acta Otolaryngol 125:1337-44. 2005
    ..The estimated proportion of OOSCC cases attributable to HPV infection was 35%...
  71. ncbi Factors associated with restricted mouth opening and its relationship to health-related quality of life in patients attending a Maxillofacial Oncology clinic
    B Scott
    Physiotherapy Department, University Hospital Aintree, Liverpool, UK
    Oral Oncol 44:430-8. 2008
    ..This study supports a 35 mm cut-off for trismus. There is merit including the two elements together (opening in mm and the single item question on mouth opening since treatment) as outcome parameters...
  72. ncbi The patients' account of outcome following primary surgery for oral and oropharyngeal cancer using a 'quality of life' questionnaire
    S N Rogers
    Regional Maxillofacial Unit, and Faculty of Health, Edge Hill University, University Hospital Aintree, Liverpool, UK
    Eur J Cancer Care (Engl) 17:182-8. 2008
    ..Information presented in this format is potentially extremely useful when counselling patients and their families regarding the likely outcomes of treatment...
  73. ncbi The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+
    Michael K Layland
    Department of Otolaryngology Head and Neck Surgery and the Head and Neck Tumor Research Project of Barnes Jewish Hospital Foundation, St Louis, Missouri 63110, USA
    Laryngoscope 115:629-39. 2005
    ..The study also compares the results of four different approaches to the treatment of the N0 neck...
  74. ncbi Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume
    K S Clifford Chao
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 59:43-50. 2004
    ....
  75. ncbi Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer
    J P Pignon
    Department of Biostatistics and Epidemiology, Institut Gustav Roussy, Villejuif, France
    Lancet 355:949-55. 2000
    ..We did three meta-analyses of the impact of survival on chemotherapy added to locoregional treatment...
  76. ncbi Cancer of the oropharynx
    Lisa Licitra
    START Project, European School of Oncology, Viale Beatrice d Este, 37, 20122 Milan, Italy
    Crit Rev Oncol Hematol 41:107-22. 2002
    ..Acute toxicity needs to be managed promptly. Late sequelae are less known. Treatment of such tumours requires a multidisciplinary approach within experienced centres...
  77. ncbi Oropharyngeal cancer incidence and mortality in Scotland: are rates still increasing?
    Kate L Robinson
    Unit of Chronic Disease Epidemiology, The Medical School, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Oral Oncol 39:31-6. 2003
    ..Although oropharyngeal cancer incidence rates continue to rise alarmingly, these increases are not necessarily translated into higher mortality rates as had been suggested by results from earlier studies...
  78. ncbi Role of surgery in limited (T1-2, N0-1) cancers of the oropharynx
    Rohan R Walvekar
    Department of Otolaryngology, Head Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Laryngoscope 118:2129-34. 2008
    ..To define the role of surgical staging in limited (T1-2, N0-1) oropharyngeal squamous cell cancers...
  79. ncbi Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets
    Angela M Hong
    Department of Radiation Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia
    Vaccine 28:3269-72. 2010
    ..56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia...
  80. ncbi Weight loss predicts mortality after recurrent oral cavity and oropharyngeal carcinomas
    Thao V Nguyen
    University of Washington School of Medicine, Seattle, WA 98108, USA
    Cancer 95:553-62. 2002
    ....
  81. ncbi Human papillomavirus genotype distribution in oropharynx and oral cavity cancer in France--The EDiTH VI study
    Jean Lacau St Guily
    Service d Oto Rhino Laryngologie et Chirurgie Cervico Faciale, Hopital Tenon, Université de Paris 6 et Faculté de Médecine Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, 4 rue de la Chine, 75970 Paris Cedex 20, France
    J Clin Virol 51:100-4. 2011
    ..Recent studies suggest an association between human papillomavirus (HPV) infection and several head and neck cancers, especially oropharyngeal and oral cavity invasive carcinomas...
  82. ncbi Volumetric modulated arc radiotherapy for carcinomas of the oro-pharynx, hypo-pharynx and larynx: a treatment planning comparison with fixed field IMRT
    Eugenio Vanetti
    Oncology Institute of Southern Switzerland, Radiation Oncology Department, Bellinzona, Switzerland
    Radiother Oncol 92:111-7. 2009
    ..A planning study was performed to evaluate the performance of volumetric modulated arc radiotherapy on head and neck cancer patients. Conventional fixed field IMRT was used as a benchmark...
  83. ncbi Current trends in initial management of oropharyngeal cancer: the declining use of open surgery
    Missak Haigentz
    Division of Oncology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Eur Arch Otorhinolaryngol 266:1845-55. 2009
    ..In this review, novel primary therapies against oropharyngeal squamous cell carcinoma are presented in the context of anatomical, quality of life, and emerging biological considerations...
  84. ncbi Predicting the effect of accelerated fractionation in postoperative radiotherapy for head and neck cancer based on molecular marker profiles: data from a randomized clinical trial
    Rafal Suwinski
    Department of Radiation Oncology, Center of Oncology, Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland
    Int J Radiat Oncol Biol Phys 77:438-46. 2010
    ....
  85. ncbi Quality of life in long-term survivors of oropharynx carcinoma
    Nicolas Pourel
    Department of Radiation Oncology, Centre Alexis Vautrin, Vandoeuvre les Nancy, France
    Int J Radiat Oncol Biol Phys 54:742-51. 2002
    ..To collect data on the health-related quality of life (QOL) of long-term survivors and to determine to what extent QOL might be an appropriate end point in the comparison of treatment options in oropharyngeal carcinoma...
  86. pmc Multi-institutional trial of accelerated hypofractionated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00-22)
    Avraham Eisbruch
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 76:1333-8. 2010
    ..To assess the results of a multi-institutional study of intensity-modulated radiation therapy (IMRT) for early oropharyngeal cancer...
  87. ncbi Squamous cell carcinoma of the oropharynx--an analysis of treatment results in 289 consecutive patients
    L V Johansen
    Department of Experimental Clinical Oncology Danish Cancer Society, Aarhus University Hospital, Denmark
    Acta Oncol 39:985-94. 2000
    ..The primary control of the carcinoma in the T-position is crucial for overall success, but salvage surgery is found to have a favourable success rate in patients suitable for relapse treatment...
  88. ncbi Concurrent chemoradiotherapy with S-1 as first-line treatment for patients with oropharyngeal cancer
    Kayoko Ohnishi
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Radiat Res 52:47-53. 2011
    ..S-1 is an oral fluoropyrimidine. The purpose of this study was to review the clinical outcomes of S-1 with concurrent radiotherapy for patients with oropharyngeal cancer...
  89. ncbi Concomitant chemoradiation versus radical radiotherapy in advanced squamous cell carcinoma of oropharynx and nasopharynx using weekly cisplatin: a phase II randomized trial
    A Sharma
    Department of Medical Oncology, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India
    Ann Oncol 21:2272-7. 2010
    ..To know the effectiveness and tolerance of weekly cisplatin added to radiotherapy (RT) in advanced carcinoma of oropharynx and nasopharynx...
  90. ncbi Decline of oropharyngeal cancer in Chiangmai province, Thailand, between 1988 and 1999
    P A Reichart
    Medical Faculty of Humboldt University, Charite, Department of Oral Surgery and Dental Radiology, Berlin, Germany
    Oral Oncol 39:569-73. 2003
    ..Changes of traditional oral habits such as betel quid chewing and smoking of traditional cigars seem to have resulted in a marked decrease of oral cancer in both men and women in the recent past...
  91. ncbi A prospective comparision of sequential chemoradiation vs concurrent chemoradiation in locally advanced oropharyngeal carcinomas
    Deepak Gupta
    Department of Radiotherapy, Chhatrapati Sahuji Maharaj Medical University, Lucknow, India
    Cancer Biol Ther 8:213-7. 2009
    ..The beneficial role of chemoradiation following induction chemotherapy over concurrent chemoradiation has not been evaluated. Present study evaluates the same prospectively...
  92. pmc Association of TGF-beta1 genetic variants with HPV16-positive oropharyngeal cancer
    Xiaoxiang Guan
    Departments of Epidemiology, and Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:1416-22. 2010
    ....
  93. ncbi Long-term results of conventional radiotherapy versus accelerated hyperfractionated radiotherapy versus concomitant radiotherapy and chemotherapy in locoregionally advanced carcinoma of the oropharynx
    Carlo Fallai
    Radioterapia 2, Istituto Nazionale Tumori, Milan, Italy
    Tumori 92:41-54. 2006
    ....
  94. ncbi Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure
    Megan E Daly
    Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA
    Int J Radiat Oncol Biol Phys 76:1339-46. 2010
    ..To report outcomes, failures, and toxicities in patients treated with intensity-modulated radiotherapy (IMRT) for squamous cell carcinoma of the oropharynx...
  95. ncbi Tumor risk assessment by means of immunocytochemical detection of early pre-malignant changes in buccal smears
    Marc M Bloching
    Department of Otolaryngology, Head and Neck Surgery, University of Saarland, Homburg, Germany
    Oncol Rep 19:1373-9. 2008
    ..05). It could be possible to use the marker MIB1 and cyclin D1 to screen risk groups, since the relative morbidity risk (odds ratio) increases (by 45-62 times) if the threshold value of 4 positively marked cell nuclei is exceeded...
  96. ncbi Current topics in the epidemiology of oral cavity and oropharyngeal cancers
    Maura L Gillison
    Division of Viral Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Head Neck 29:779-92. 2007
    ..Special emphasis is placed on evaluating possible risk differences in individuals above and below the age of 45 and in users and nonusers of alcohol and tobacco...
  97. ncbi Prognostic significance of presentation-to-diagnosis interval in patients with oropharyngeal carcinoma
    Tang Ho
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Arch Otolaryngol Head Neck Surg 130:45-51. 2004
    ..To evaluate the prognostic impact of presentation-to-diagnosis interval (PDI) and its association with other clinical factors in patients with oropharyngeal squamous cell carcinoma (OpSCC)...
  98. ncbi Long-term follow-up and a detailed prognostic analysis of patients with oropharyngeal cancer treated with radiotherapy
    Natsuo Tomita
    Department of Radiation Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusaku, Nagoya, 464 8681, Japan
    J Cancer Res Clin Oncol 136:617-23. 2010
    ..To find a prognostic factor for patients with oropharyngeal cancer (OPC) who were followed for long term after definitive radiotherapy...
  99. ncbi Patient-perceived and objective functional outcomes following transoral robotic surgery for early oropharyngeal carcinoma
    Catherine F Sinclair
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, 1530 Third Ave S, Birmingham, AL 35294 0012, USA
    Arch Otolaryngol Head Neck Surg 137:1112-6. 2011
    ..To evaluate changes in patient-perceived swallowing function over time following transoral robotic surgery (TORS) for primary T1 and T2 oropharyngeal squamous cell carcinomas...
  100. ncbi Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: an update of the Memorial Sloan-Kettering Cancer Center experience
    Jeremy Setton
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 82:291-8. 2012
    ..To update the Memorial Sloan-Kettering Cancer Center's experience with intensity-modulated radiotherapy (IMRT) in the treatment of oropharyngeal cancer (OPC)...
  101. ncbi Effects of xerostomia on perception and performance of swallow function
    J A Logemann
    Department of Communication Sciences and Disorders, Northwestern University, 2299 North Campus Drive, Evanston, Illinois 60208, USA
    Head Neck 23:317-21. 2001
    ..Saliva weight in patients who perceive swallowing problems was lower. Xerostomia did not affect the physiologic aspects of bolus transport. Xerostomia affected the sensory process and comfort of eating more than bolus transport...

Research Grants35

  1. PREVALENCE AND DETERMINANTS OF ORAL HPV INFECTION IN THE US POPULATION
    Maura L Gillison; Fiscal Year: 2013
    ....
  2. HPV-Specific, Immune Suppression in Patients with RRP
    VINCENT ROBERT BONAGURA; Fiscal Year: 2013
    ....
  3. Diagnosis of Cancer with High-Resolution Ultrasound
    Frank Djuth; Fiscal Year: 2004
    ..abstract_text> ..
  4. Oral HPV Infection in HIV-Infected Men and Women
    Maura Gillison; Fiscal Year: 2008
    ..This proposal has the potential to yield information important for future efforts at primary prevention and early detection of HPV-HNSCC. ..
  5. A Therapeutic Vaccine for HPV 16-Positive Head and Neck Cancer
    Maura Gillison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Facilitating Alcohol Screening of Hypertensive Patients
    Peter Miller; Fiscal Year: 2006
    ..Such screening and intervention should improve blood pressure control in many of these patients and, in turn, reduce risk of chronic disease and death. ..
  7. Adoption of Pharmacotherapy in Alcoholism Treatment
    Peter Miller; Fiscal Year: 2005
    ..abstract_text> ..
  8. BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK
    Maria Worsham; Fiscal Year: 2001
    ....
  9. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..
  10. Effects of Swallowing Therapy in Head and Neck Cancer
    Jerilyn Logemann; Fiscal Year: 2006
    ....
  11. Effects of LSVT on Dysphagia in Parkinson's Disease
    Jerilyn Logemann; Fiscal Year: 2003
    ..This application proposes to generate pilot data on the effects of LSVT on aspiration, a potentially dangerous and costly side effect of dysphagia in Parkinson's disease. ..
  12. Oropharyngeal Function After Radiotherapy with IMRT
    Jerilyn A Logemann; Fiscal Year: 2010
    ..This project attempts to quantify the swallow problems associated with this specific treatment and the effects of interventions for these swallow problems. ..
  13. Functional Infrared Imaging Predicts Radiation Mucositis
    Ezra Cohen; Fiscal Year: 2008
    ..Such a tool would have wide applicability in this patient population and would have tremendous impact on their treatment. [unreadable] [unreadable] [unreadable]..
  14. Mutational load in buccal cells from lung cancer patients and controls
    Robbert Slebos; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Use of Serum HPV16 DNA as a Marker for Oropharyngeal Cancer Recurrence
    Erich Sturgis; Fiscal Year: 2008
    ..abstract_text> ..
  16. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2008
    ..abstract_text> ..
  17. HYPOXIC IMAGING GUIDED INTENSITY MODULATED RADIOTHERAPY
    KS CLIFFORD CHAO; Fiscal Year: 2003
    ..They will test the hypothesis by performing multiple Cu-60 ATSM PET scans during the course of irradiation to understand the spatial evolution of hypoxic tumor. ..
  18. Rapamycin as an Antineoplastic Agent
    Ezra Cohen; Fiscal Year: 2006
    ..At the conclusion of the trial RAPA toxicity and effect on p-S6K will be defined over a range of doses as well as the MTD for use in future studies that will develop this agent. ..
  19. International Collaborative HNC Research
    Elaine Smith; Fiscal Year: 2007
    ..This aim is to determine whether there is an easily administered, sensitive biomarker that can predict HPV-HR status in HNC tumors prior to therapy.. [unreadable] [unreadable] [unreadable]..
  20. Genetic analysis of congenital diaphragmatic hernia
    Anne Slavotinek; Fiscal Year: 2006
    ..abstract_text> ..
  21. Periodontal Disease and the Incidence of Oral Cancer
    Mine Tezal; Fiscal Year: 2007
    ..Prevention of oral cancer could begin with prevention and early treatment of periodontitis. [unreadable] [unreadable] [unreadable]..
  22. MR Dynamic Imaging and Spectroscopy in Head & Neck Cancers
    AMITA DAVE; Fiscal Year: 2010
    ..If successful, it will provide an a priori predictor of failure/response to chemotherapy and/or long term disease free-survival, resulting in patient specific treatment which will likely enhance outcome. ..
  23. Quality of Life Conference in Head & Neck Cancer
    Bevan Yueh; Fiscal Year: 2002
    ..abstract_text> ..
  24. HPV ETIOLOGY OF A SUBSET OF HEAD AND NECK CANCERS
    Keerti Shah; Fiscal Year: 2004
    ..If HPV etiology is established for a subset of HNSCC, patients with these tumors may benefit from HPV-specific immunotherapies which are being evaluated for the treatment of invasive cervical cancer. ..
  25. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2003
    ..abstract_text> ..
  26. Biology of Headpin (a novel serpin) in Oral Cancer
    Gary Clayman; Fiscal Year: 2006
    ..Progress in this area could lead to development of new molecular based targets for the management of oral cancer. ..
  27. Radiosensitization with the HIV protease inhibior Nelfinavir in NSCLC
    Anjali Gupta; Fiscal Year: 2008
    ..Specific Aim 3. To investigate in vitro the molecular mechanisms by which NFV results in sensitization. [unreadable] [unreadable] [unreadable]..
  28. The Zebrafish Radioresponse for High-Throughput and -Content Molecular Screening
    Gary Kao; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. North Carolina Needs Assessment for Oral Cancer Control
    Lauren Patton; Fiscal Year: 2003
    ....
  30. HDAC4 Viability: Unique Mechanisms and Function
    Gary Kao; Fiscal Year: 2007
    ..When aspects of this unique and vital feedback loop are interrupted, cellular death ensues. ..
  31. Early Prediction of Pathological Response of Chemoradiotherapy with FLT PET
    KS CLIFFORD CHAO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2006
    ..It is expected that Dr. Monk will have obtained extramural funding for both his laboratory and clinical studies by the end of the period of support requested. ..
  33. Tonsil Model of Oral HIV-1 Infection via Breastfeeding
    Diane Shugars; Fiscal Year: 2003
    ....
  34. HERPES SIMPLEX VIRUS IN THE TREATMENT OF ORAL CANCER
    EDWARD SHILLITOE; Fiscal Year: 2004
    ..abstract_text> ..