tympanic membrane perforation

Summary

Summary: An opening in the tympanic membrane usually caused by trauma. There are four general categories: compression injuries (the most common and usually the result of a blow to the ear); instrumentation injuries (the second most common, usually inadvertent, caused often by cotton swabs or bobby-pins); burn-slag injuries (frequently seen in industry, from hot metal from machines or welding); and blast injuries (usually seen during war or as a result of terrorist bombing). In the absence of infection, most traumatic tympanic membrane perforations heal spontaneously. Persistent perforation is usually a manifestation of tubotympanitis, an inflammation of the eustachian tube and tympanic cavity (middle ear). (From Paparella, Shumrick, Gluckman, and Meyerhoff: Otolaryngology, vol. II, 3d ed, pp1363-65)

Top Publications

  1. ncbi Type 1 Tympanoplasty in Benin: a 10- year review
    F O Ogisi
    Department of Surgery, University of Benin Teaching Hospital, Benin City, Nigeria
    Niger Postgrad Med J 11:84-7. 2004
  2. ncbi Laser therapy for refractory myringitis in children
    Frank P Fechner
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA
    Otolaryngol Head Neck Surg 127:163-8. 2002
  3. ncbi Reevaluation of bilateral same-day surgery for bilateral perforated chronic otitis media
    Hirokazu Katsura
    Department of Otolaryngology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Otol Neurotol 26:842-5. 2005
  4. ncbi Stem cells and enhanced healing of chronic tympanic membrane perforation
    Anisur Rahman
    Department of Otorhinolaryngology, Karolinska Institute Karolinska University Hospital, Stockholm, Sweden
    Acta Otolaryngol 128:352-9. 2008
  5. ncbi Antibiotics for acute otitis media in children
    Roderick P Venekamp
    Department of Otorhinolaryngology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    Cochrane Database Syst Rev 1:CD000219. 2013
  6. ncbi Tympanoplasty after war blast lesions of the eardrum: retrospective study
    N Sprem
    Ear, Nose and Throat Department, Zagreb University Hospital Center, Croatia
    Croat Med J 42:642-5. 2001
  7. ncbi Determinants of spontaneous healing in traumatic perforations of the tympanic membrane
    F T Orji
    Department of Otolaryngology, Federal Medical Center Umuahia, Abia State, Nigeria
    Clin Otolaryngol 33:420-6. 2008
  8. ncbi Otologic surgery following ear trauma
    J Matthew Conoyer
    Otology Group of Vanderbilt, Department of Otolaryngology Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA
    Otolaryngol Head Neck Surg 137:757-61. 2007
  9. ncbi Tympanic membrane perforation and hearing loss from blast overpressure in Operation Enduring Freedom and Operation Iraqi Freedom wounded
    Amber E Ritenour
    United States Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:S174-8; discussion S178. 2008
  10. pmc Otitis media in young Aboriginal children from remote communities in Northern and Central Australia: a cross-sectional survey
    Peter S Morris
    Ear Health and Education Unit, Menzies School of Health Research, Darwin, Australia
    BMC Pediatr 5:27. 2005

Research Grants

  1. Crosslinkable Hydrogels for Tympanic Membrane Repair
    Glenn Prestwich; Fiscal Year: 2004
  2. Middle-ear assessment via reflectance measurements
    Susan Voss; Fiscal Year: 2005
  3. Ear Biomechanics for Restoration of Hearing
    RONG GAN; Fiscal Year: 2009
  4. EPIDEMIOLOGY OF OTITIS MEDIA IN NATIVE AMERICAN CHILDREN
    Kathleen Daly; Fiscal Year: 2001
  5. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
  6. Otitis Media Core Center
    Kathleen Daly; Fiscal Year: 2005
  7. Sustained Release Inner Ear Delivery of Corticosteroid
    William Slattery; Fiscal Year: 2007
  8. GENETIC EPIDEMIOLOGY OF CHRONIC/RECURRENT OTITIS MEDIA
    KATHLEEN ANN DALY; Fiscal Year: 2010

Detail Information

Publications227 found, 100 shown here

  1. ncbi Type 1 Tympanoplasty in Benin: a 10- year review
    F O Ogisi
    Department of Surgery, University of Benin Teaching Hospital, Benin City, Nigeria
    Niger Postgrad Med J 11:84-7. 2004
    ....
  2. ncbi Laser therapy for refractory myringitis in children
    Frank P Fechner
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA
    Otolaryngol Head Neck Surg 127:163-8. 2002
    ..We present the application and initial results of a CO(2) laser technique for the treatment of medically refractory chronic granular myringitis (CGM)...
  3. ncbi Reevaluation of bilateral same-day surgery for bilateral perforated chronic otitis media
    Hirokazu Katsura
    Department of Otolaryngology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Otol Neurotol 26:842-5. 2005
    ..To evaluate the results of bilateral same-day surgery for bilateral perforated chronic otitis media in comparison with our previous report...
  4. ncbi Stem cells and enhanced healing of chronic tympanic membrane perforation
    Anisur Rahman
    Department of Otorhinolaryngology, Karolinska Institute Karolinska University Hospital, Stockholm, Sweden
    Acta Otolaryngol 128:352-9. 2008
    ..This provides a basis for the exploration of stem cell treatment for TM perforations and holds promise for future improvements...
  5. ncbi Antibiotics for acute otitis media in children
    Roderick P Venekamp
    Department of Otorhinolaryngology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    Cochrane Database Syst Rev 1:CD000219. 2013
    ..Acute otitis media (AOM) is one of the most common diseases in early infancy and childhood. Antibiotic use for AOM varies from 56% in the Netherlands to 95% in the USA, Canada and Australia...
  6. ncbi Tympanoplasty after war blast lesions of the eardrum: retrospective study
    N Sprem
    Ear, Nose and Throat Department, Zagreb University Hospital Center, Croatia
    Croat Med J 42:642-5. 2001
    ..To establish whether hearing loss after eardrum blast injury could be recovered by tympanoplasty performed immediately after injury and what material is the most suitable for eardrum closure...
  7. ncbi Determinants of spontaneous healing in traumatic perforations of the tympanic membrane
    F T Orji
    Department of Otolaryngology, Federal Medical Center Umuahia, Abia State, Nigeria
    Clin Otolaryngol 33:420-6. 2008
    To analyse the various factors influencing spontaneous healing of traumatic tympanic membrane perforation in West Africa.
  8. ncbi Otologic surgery following ear trauma
    J Matthew Conoyer
    Otology Group of Vanderbilt, Department of Otolaryngology Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA
    Otolaryngol Head Neck Surg 137:757-61. 2007
    ..To investigate common presentations and expected outcomes in patients with traumatically induced otologic dysfunction...
  9. ncbi Tympanic membrane perforation and hearing loss from blast overpressure in Operation Enduring Freedom and Operation Iraqi Freedom wounded
    Amber E Ritenour
    United States Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:S174-8; discussion S178. 2008
    b>Tympanic membrane perforation is the most common primary blast injury in the current conflicts and occurs in approximately one tenth of service members wounded by combat explosions...
  10. pmc Otitis media in young Aboriginal children from remote communities in Northern and Central Australia: a cross-sectional survey
    Peter S Morris
    Ear Health and Education Unit, Menzies School of Health Research, Darwin, Australia
    BMC Pediatr 5:27. 2005
    ..The aim of the study was to determine the prevalence of middle ear disease (otitis media) in a high-risk population of young Aboriginal children from remote communities in Northern and Central Australia...
  11. ncbi A randomised controlled trial comparing spontaneous healing, gelfoam patching and edge-approximation plus gelfoam patching in traumatic tympanic membrane perforation with inverted or everted edges
    Z C Lou
    Department of Otorhinolaryngology, Yiwu Central Hospital, Zhejiang, China
    Clin Otolaryngol 36:221-6. 2011
    To compare the outcome of patients with dry traumatic tympanic membrane perforation after spontaneous healing and gelfoam patching with or without perforation edge approximation.
  12. ncbi Mediolateral graft tympanoplasty for anterior or subtotal tympanic membrane perforation
    Timothy T K Jung
    Division of Otolaryngology, Head and Neck Surgery, Loma Linda University School of Medicine and Jerry L Pettis Memorial Veterans Medical Center, Loma Linda, CA 92354, USA
    Otolaryngol Head Neck Surg 132:532-6. 2005
    ..To describe and evaluate the mediolateral graft tympanoplasty for the reconstruction of anterior or subtotal tympanic membrane (TM) perforation...
  13. ncbi Traumatic tympanic membrane perforations: clinical and audiometric findings in 198 patients
    John Martin Hempel
    Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilian University, Munich, Germany
    Otol Neurotol 33:1357-62. 2012
    ..To obtain clinical and audiometric findings in traumatic tympanic membrane perforations from a typical patient collective in a Western industrial nation because the appropriate data have an important relevance in medicolegal questions...
  14. ncbi Repair of large traumatic tympanic membrane perforation with a Steri-Strips patch
    Moo Kyun Park
    Department of Otolaryngology Head and Neck Surgery, Soonchunhyang University College of Medicine, Seoul, Korea
    Otolaryngol Head Neck Surg 145:581-5. 2011
    ..To investigate the effects of the Steri-Strips patch (3M) on the treatment of large traumatic tympanic membrane perforations (TMP)...
  15. pmc The clinical course of acute otitis media in high-risk Australian Aboriginal children: a longitudinal study
    Katherine B Gibney
    Department of Medicine, Royal Darwin Hospital, Australia
    BMC Pediatr 5:16. 2005
    ..Our aim was to describe the clinical course of AOM and the associated bacterial nasopharyngeal colonisation in a high-risk population of Australian Aboriginal children...
  16. ncbi Basic fibroblast growth factor combined with atelocollagen for closing chronic tympanic membrane perforations in 87 patients
    Nobuhiro Hakuba
    Department of Otolaryngology Head and Neck Surgery, Osaka Red Cross Hospital, Osaka, Japan
    Otol Neurotol 31:118-21. 2010
    ..To present the clinical results of closing chronic tympanic membrane (TM) perforations using basic fibroblast growth factor (bFGF) combined with an atelocollagen/silicone bilayer membrane patch...
  17. ncbi Loop overlay tympanoplasty for anterior or subtotal perforations
    Heung Yeup Lee
    Department of Otolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Auris Nasus Larynx 37:162-6. 2010
    ..To report our experience with "loop overlay" tympanoplasty, a modified overlay technique with a superiorly based skin flap, for the reconstruction of anterior, subtotal or total tympanic membrane (TM) perforations...
  18. ncbi Healing large traumatic eardrum perforations in humans using fibroblast growth factor applied directly or via gelfoam
    Zhengcai Lou
    Department of Otorhinolaryngology, The Affiliated Yiwu Hospital of Wenzhou Medical College, Zhejiang, China
    Otol Neurotol 33:1553-7. 2012
    ..The goal of this study was to evaluate the effects of conservative treatment and fibroblast growth factor (FGF) applied directly or via Gelfoam on the healing of large traumatic tympanic membrane perforations (TMPs) in humans...
  19. ncbi Fat graft myringoplasty with the newly developed surgical technique for chronic tympanic membrane perforation
    Sema Koc
    Department of Otorhinolaryngology, Gaziosmanpasa University School of Medicine, Tokat, Turkey
    Eur Arch Otorhinolaryngol 270:1629-33. 2013
    ..Thirty consecutive patients with persistent tympanic membrane perforation were included in this study...
  20. ncbi A multivariate analysis of otological, surgical and patient-related factors in determining success in myringoplasty
    K Onal
    First ENT Clinic, Ataturk Training and Research Hospital, Izmir, Turkey
    Clin Otolaryngol 30:115-20. 2005
    ..The aim of this study was to evaluate the effects of smoking and other prognostic factors on long-term surgical outcome and hearing results in myringoplasty...
  21. ncbi Medial or medio-lateral graft tympanoplasty for repair of tympanic membrane perforation
    Timothy Jung
    Division of Otolaryngology Head and Neck Surgery, Loma Linda University, Loma Linda, CA, USA
    Int J Pediatr Otorhinolaryngol 73:941-3. 2009
    ..To describe and evaluate the medio-lateral graft tympanoplasty(1) for the reconstruction of anterior or subtotal tympanic membrane (TM) perforation and medial graft tympanoplasty for posterior TM perforation...
  22. ncbi A prospective study evaluating spontaneous healing of aetiology, size and type-different groups of traumatic tympanic membrane perforation
    Z C Lou
    Department of Otorhinolaryngology, Yiwu Central Hospital, Zhejiang Department of Pathology, Yiwu Central Hospital, Zhejiang, China
    Clin Otolaryngol 36:450-60. 2011
    ..To evaluate the outcome of spontaneous healing of aetiology-, size- and type-different groups of acute traumatic eardrum perforation and to characterise changes in the morphology of the healing eardrum in various conditions...
  23. ncbi Regenerative treatment for tympanic membrane perforation
    Shin Ichi Kanemaru
    Department of Otolaryngology Head and Neck Surgery, Medical Research Institute, Kitano Hospital, Osaka, Japan
    Otol Neurotol 32:1218-23. 2011
    To establish a tissue engineering therapy for the treatment of large tympanic membrane perforation (TMP) without the need for conventional surgical therapy.
  24. ncbi Over-under tympanoplasty
    Jack M Kartush
    Michigan Ear Institute, Farmington Hills 48334, USA
    Laryngoscope 112:802-7. 2002
    ..The over-under tympanoplasty, an innovative method for tympanic membrane repair, will be described as a reliable alternative that has advantages over traditional procedures...
  25. ncbi Chronic tympanic membrane perforation: a better animal model is needed
    Peter L Santa Maria
    Ear Sciences Centre, School of Surgery and Pathology, University of Western Australia, Perth, Western Australia, Australia
    Wound Repair Regen 15:450-8. 2007
    Developments in the treatment of chronic tympanic membrane perforation have been hindered by the lack of an ideal animal model...
  26. ncbi Plasmin/plasminogen is essential for the healing of tympanic membrane perforations
    Jinan Li
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    Thromb Haemost 96:512-9. 2006
    ....
  27. ncbi Tympanic membrane perforation: size, site and hearing evaluation
    Issam Saliba
    Sainte Justine University Hospital Center CHU SJ, 3175, Cote Sainte Catherine, Department of Otorhinolaryngology, Montreal, QC, H3T 1C5, Canada
    Int J Pediatr Otorhinolaryngol 75:527-31. 2011
    ..To assess different clinical scales of TM perforation size; to evaluate the effect of the size and the site of a perforation on the hearing level and frequencies...
  28. ncbi Functional correlations of tympanic membrane perforation size
    Bob Lerut
    Department of Otorhinolaryngology, Head and Neck Surgery, AZ Sint Jan Brugge Oostende AV, Campus Brugge, Bruges, West Vlaanderen, Belgium
    Otol Neurotol 33:379-86. 2012
    ..The correlation between tympanic membrane perforations and hearing loss was studied...
  29. ncbi Fresh tympanic membrane perforations heal without significant loss of strength
    Anisur Rahman
    Center for Hearing and Communication Research and Department of Otorhinolaryngology, Karolinska University Hospital and Institute, Stockholm, Sweden
    Otol Neurotol 26:1100-6. 2005
    ..The mechanical and structural properties of the tympanic membrane change after a perforation has healed...
  30. ncbi Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application
    Yuanxui Ma
    Tianjin Institute of Otorhinolaryngology, First Central Hospital, Tianjin Medical University, Tianjin, People s Republic of China
    Acta Otolaryngol 122:586-99. 2002
    ....
  31. ncbi Quantitative analysis of tympanic membrane perforation: a simple and reliable method
    T S Ibekwe
    Department of Surgery, Division of ENT, Irrua Specialist Teaching Hospital, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
    J Laryngol Otol 123:e2. 2009
    Accurate assessment of the features of tympanic membrane perforation, especially size, site, duration and aetiology, is important, as it enables optimum management.
  32. ncbi Cartilage tympanoplasty: indications, techniques, and outcomes in a 1,000-patient series
    John Dornhoffer
    Department of Otolaryngology Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Laryngoscope 113:1844-56. 2003
    ..Our hypothesis was that pathology and status of the ossicular chain should dictate the technique used to achieve optimal outcome...
  33. ncbi Lack of plasminogen does not alter the early inflammatory response following a tympanic membrane perforation: a study in plasminogen-deficient mice
    Annika Hansson Prestwich
    Department of Clinical Sciences, Otorhinolaryngology, Umea University, Umea, Sweden
    Acta Otolaryngol 128:1294-302. 2008
    ....
  34. ncbi [Near infrared stimulation of the equilibrium organ--first clinical experiences]
    L E Walther
    Universitäts HNO Klinik, Friedrich Schiller Universitat Jena
    Laryngorhinootologie 82:687-92. 2003
    ..This method should be examined within the framework of a pilot study, evaluated and its clinical possible applications examined...
  35. ncbi [Selective stimulation of the equilibrium organ using monochromatic near infrared]
    L E Walther
    Universitäts HNO Klinik, Friedrich Schiller Universitat Jena
    Laryngorhinootologie 83:88-95. 2004
    ....
  36. ncbi Minimally invasive inlay and underlay tympanoplasty
    Wen Hung Wang
    Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Pu tzu City, Chiayi County, Taiwan
    Am J Otolaryngol 29:363-6. 2008
    ....
  37. ncbi Myringoplasty: surgical outcomes and hearing improvement: is it worth performing to improve hearing?
    M Karela
    ENT Department, Singleton Hospital, Swansea NHS Trust, Swansea, UK
    Eur Arch Otorhinolaryngol 265:1039-42. 2008
    ..Patients who undergo myringoplasty should be advised whilst been consented that there is a good chance of hearing improvement...
  38. ncbi Myringoplasty
    R Aggarwal
    Department of ENT, Royal Albert Edward Infirmary, Wigan, UK
    J Laryngol Otol 120:429-32. 2006
    ..This study reviews the factors thought to determine the likelihood of achieving complete closure of the tympanic membrane following surgical closure...
  39. ncbi Comparative study of the underlay and overlay techniques of myringoplasty in large and subtotal perforations of the tympanic membrane
    Mangal Singh
    Department of Otorhinolaryngology, Head and Neck Surgery, M L N Medical College, Nazreth Hospital, Allahabad, India
    J Laryngol Otol 117:444-8. 2003
    ..8 per cent vs 57.1 per cent) and fewer minor complications (6.6 per cent vs 33.3 per cent)...
  40. ncbi Myringoplasty: does the size of the perforation matter?
    P Lee
    The Department of Otolaryngology, The Royal Infirmary of Edinburgh, Edinburgh, UK
    Clin Otolaryngol Allied Sci 27:331-4. 2002
    ..039) in successful myringoplasties, a positive value indicating an improvement in hearing. This change is unlikely to be clinically significant. Patients should be made aware of these facts when informed consent is being obtained...
  41. ncbi Prognosis and outcome of the tympanic membrane flap at traumatic tympanic membrane perforation edge
    Zheng Cai Lou
    Department of Otorhinolaryngology, Yiwu Central Hospital, Zhejiang, China
    ORL J Otorhinolaryngol Relat Spec 73:212-8. 2011
    ..Chart records of 329 patients with a single ear traumatic tympanic membrane perforation were retrieved and analyzed...
  42. ncbi Chronic suppurative otitis media and related complications at the University Clinic of Kinshasa
    R N Matanda
    Service d Oto Rhino Laryngologie, Cliniques Universitaires de Kinshasa, Université de Kinshasa B P 123 Kinshasa XI République Démocratique du Congo
    B-ENT 1:57-62. 2005
    ..Our data suggest that the prevalence of CSOM in the Kinshasa area is at least 4% and, in fact, has not declined over the last 20 years...
  43. ncbi Tympanoplasty in pediatric patients
    Yavuz Uyar
    Department of Otorhinolaryngology, Meram Medical Faculty, Selcuk University, Konya, Turkey
    Int J Pediatr Otorhinolaryngol 70:1805-9. 2006
    ..The aim of this study is to analyze the clinical features and follow-up of a series of pediatric patients with chronic otitis media undergoing tymponaplasty surgery and to identify the effect of the factors on the course...
  44. ncbi Tympanic membrane perforation repair with acellular porcine submucosa
    Jeffrey H Spiegel
    Department of Otolaryngology Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts, USA
    Otol Neurotol 26:563-6. 2005
    ..In this study, we examined the use of small intestine submucosa in the repair of chronic tympanic membrane perforations in a chinchilla model...
  45. ncbi Myringoplasty: is it worth performing in children?
    N Umapathy
    Department of Otolaryngology, City Hospital, Birmingham, England
    Arch Otolaryngol Head Neck Surg 129:1053-5. 2003
    ..To evaluate the results of myringoplasty in children 4 to 14 years old at the time of surgery...
  46. ncbi Pediatric myringoplasty: factors that affect success-a retrospective study
    Joshua S Sckolnick
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Laryngoscope 118:723-9. 2008
    ..To evaluate the impact of patient and graft variables on the successful closure of tympanic membrane perforations treated with myringoplasty at the Children's Hospital of Pittsburgh from 2000 to 2005...
  47. ncbi Tympanic membrane perforation and retained metal slag after a welding injury
    Jeffrey P Simons
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Otolaryngol Head Neck Surg 133:635-6. 2005
  48. pmc Non-ossicular signal transmission in human middle ears: Experimental assessment of the "acoustic route" with perforated tympanic membranes
    Susan E Voss
    Picker Engineering Program, Smith College, 51 College Lane, Northampton, Massachusetts 01063, USA
    J Acoust Soc Am 122:2135-53. 2007
    ..Some features of the frequency dependence of H(P(CAV) ) and H(WPD) can be interpreted in terms of a structure-based lumped-element acoustic model of the perforation and middle-ear cavities...
  49. pmc Compared to placebo, long-term antibiotics resolve otitis media with effusion (OME) and prevent acute otitis media with perforation (AOMwiP) in a high-risk population: a randomized controlled trial
    Amanda J Leach
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    BMC Pediatr 8:23. 2008
    ..For children at high risk of chronic suppurative otitis media (CSOM), strategies to prevent acute otitis media with perforation (AOMwiP) may reduce progression to CSOM...
  50. ncbi Myringoplasty in children: anatomical and functional results
    L Pignataro
    Dipartimento di Scienze Otorinolaringologiche Ospedale Maggiore I.R.C.C.S, 20122 Milano, Italy
    J Laryngol Otol 115:369-73. 2001
    ..The status of the middle ear (i.e. the presence of a dry ear), significantly improves surgical outcome; and so careful inflammatory changes in the middle-ear mucosa should be evaluated and medical treatment considered before surgery...
  51. pmc Finite element modeling of sound transmission with perforations of tympanic membrane
    Rong Z Gan
    School of Aerospace and Mechanical Engineering, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Acoust Soc Am 126:243-53. 2009
    ..The FE model provides reasonable predictions on effects of perforation size and location on middle ear transfer function. The middle ear structure-function relationship can be revealed with multi-field coupled FE analysis...
  52. ncbi Observation of hearing loss in patients with chronic suppurative otitis media tubotympanic type
    M Maharjan
    Department of Ear Nose and Throat, Kathmandu Medical College Teaching Hospital, Sinamangal, Nepal
    Kathmandu Univ Med J (KUMJ) 7:397-401. 2009
    It is acknowledged that size and site of tympanic membrane perforation is proportional to degree of hearing loss but there are many studies which suggests otherwise...
  53. ncbi Middle-ear function with tympanic-membrane perforations. I. Measurements and mechanisms
    S E Voss
    Picker Engineering Program, Smith College, Northampton, Massachusetts 01063, USA
    J Acoust Soc Am 110:1432-44. 2001
    ..The quantitative description of perforation-induced losses may help clinicians determine, in an ear with a perforation, whether poor hearing results only from the perforation or whether other pathology should be expected...
  54. ncbi Direct application of keratinocyte growth factor, basic fibroblast growth factor and transforming growth factor-alpha during healing of tympanic membrane perforation in glucocorticoid-treated rats
    Shin Ichi Ishimoto
    Department of Otolaryngology, University of Tokyo, Japan
    Acta Otolaryngol 122:468-73. 2002
    ..Only KGF, therefore, improved epidermal migration in the TM, while all the growth factors tested induced hyperplasia in the TM...
  55. ncbi How do tympanic-membrane perforations affect human middle-ear sound transmission?
    S E Voss
    Easton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston 02144, USA
    Acta Otolaryngol 121:169-73. 2001
    ..A quantitative model predicts the influence of middle-ear air-space volume on loss; with larger volumes, loss is smaller...
  56. ncbi The effects of hyaluronic acid, epidermal growth factor, and mitomycin in an experimental model of acute traumatic tympanic membrane perforation
    Enis Alpin Guneri
    Department of Otolaryngology, Dokuz Eylul University Medical School, Izmir, Turkey
    Otol Neurotol 24:371-6. 2003
    ..The goal of this study was to evaluate the effects of hyaluronic acid, epidermal growth factor, and mitomycin C on the healing of acute experimental traumatic perforations of the tympanic membrane...
  57. ncbi Tympanic membrane perforation among adults in West Africa
    Titus S Ibekwe
    Department of Otorhinolaryngology, University College Hospital, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Otol Neurotol 28:348-52. 2007
    ..The knowledge of variations of the tympanic membrane (TM) perforations with the climatic changes in the West African subregion would help clinicians in its prevention and management...
  58. ncbi Long-term follow-up evaluation of mastoidectomy in children with non-cholesteatomatous chronic suppurative otitis media
    Jonas Rickers
    ENT Department, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Int J Pediatr Otorhinolaryngol 70:711-5. 2006
    ..The purpose of the present study was to evaluate the long-term effects of mastoidectomy combined with myringotomy and exploration of the middle ear in children with CSOM...
  59. ncbi Role of transtympanic myringoplasty in modern otology
    Gautam Bir Singh
    Department of Otorhinolaryngology and Head and Neck Surgery, Institute of Medical Sciences and Sir Sunderlal Hospital, Banaras Hindu University, Varanasi, Uttar Pradesh, India
    J Otolaryngol 35:408-12. 2006
    ..This study evaluates the success rate of transtympanic myringoplasty and defines its role in the current era...
  60. ncbi Subannular ventilation tubes: retrospective study
    Jean François Cloutier
    Otolaryngology Program, University of Montreal, Montreal, QC
    J Otolaryngol 34:312-6. 2005
    ..To evaluate the efficiency of a subannular tube insertion technique in a group of pediatric patients with adhesive otitis or severe atelectasis of the tympanic membrane...
  61. ncbi Palisade cartilage tympanoplasty for management of subtotal perforations: a comparison with the temporalis fascia technique
    K Cagdas Kazikdas
    Department of Otorhinolaryngology, Ankara Military Hospital, Ankara, Turkey
    Eur Arch Otorhinolaryngol 264:985-9. 2007
    ....
  62. ncbi Natural course of tympanic membrane pathology related to otitis media and ventilation tubes between ages 8 and 18 years
    B A De Beer
    Department of Otorhinolaryngology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Otol Neurotol 26:1016-21. 2005
    ..To present the course of tympanic membrane pathology in childhood and young adulthood after otitis media (OM) in early life...
  63. ncbi Effect of the thickness of the cartilage disk on the hearing results after perichondrium/cartilage island flap tympanoplasty
    Ahmed Atef
    Department of Otolaryngology, Faculty of Medicine, Cairo University, Cairo, Egypt
    ORL J Otorhinolaryngol Relat Spec 69:207-11. 2007
    ..Our hypothesis was that thinning the rigid thick cartilage disk to half of its thickness could increase the compliance and give better acoustic gain and hearing results to patients with a reconstructed tympanic membrane...
  64. ncbi Preoperative topical ofloxacin solution for tympanoplasty: a randomized, controlled study
    Michael C F Tong
    Division of Otorhinolaryngology, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territory, Hong Kong, People s Republic of China
    Otol Neurotol 23:18-20. 2002
    ..To establish the efficacy of immediate preoperative ototopical ofloxacin eardrops in eradicating middle ear pathogens and improving operative outcome...
  65. ncbi Modified house tympanoplasty for successful closure of near-total tympanic membrane perforations
    Andris Blokmanis
    Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, British Columbia
    J Otolaryngol 33:370-6. 2004
    ..To demonstrate the use of a modified House technique in the successful closure of near-total tympanic membrane perforations...
  66. ncbi Bilateral myringoplasty in chronic otitis media
    Per Caye-Thomasen
    Departments of Oto Rhino Laryngology, Head and Neck Surgery, Gentofte University Hospital of Copenhagen, Hellerup, Denmark
    Laryngoscope 117:903-6. 2007
    ..This paper presents results of bilateral surgery in 26 patients...
  67. ncbi Total tympanic membrane reconstruction: AlloDerm versus temporalis fascia
    Andrew J Fishman
    Department of Otolaryngology, New York University School of Medicine, New York University Medical Center, NY 10016, USA
    Otolaryngol Head Neck Surg 132:906-15. 2005
    ..The specific aim of this report is to assess the safety and efficacy of TTMR and to compare the results obtained with AlloDerm compared with temporalis fascia as a grafting material...
  68. ncbi Epithelial migration of the postmyringoplasty tympanic membrane
    Kee Kong Deong
    Department of Otolaryngology, University Malaya Medical Center, Kuala Lumpur, Malaysia
    Otol Neurotol 27:855-8. 2006
    ..To determine whether the postmyringoplasty tympanic membrane (TM) behaves in a similar way compared with a healthy nonoperated eardrum by calculating and comparing the epithelial migration rate and pattern...
  69. ncbi [Myringoplasty with a soft tissue plug in cases of residual perforations after tympanoplasty]
    Achim Franzen
    Klinik für HNO Krankheiten und Plastische Operationen, Ruppiner Kliniken GmbH, Neuruppin
    Laryngorhinootologie 84:722-4. 2005
  70. ncbi Biomechanical modeling and design optimization of cartilage myringoplasty using finite element analysis
    Chia Fone Lee
    Department of Otolaryngology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC
    Audiol Neurootol 11:380-8. 2006
    ..Furthermore, thicknesses of 0.2 mm at lower frequencies and 0.1 mm at higher frequencies were regarded as good compromises between sufficient mechanical stability and low acoustic transfer loss...
  71. ncbi Myringoplasty in the outpatient clinic
    H Naganuma
    Department of Otorhinolaryngology, Kitasato University School of Medicine, Kanagawa, Japan
    Acta Otorhinolaryngol Belg 48:59-65. 1994
    ..This paper discusses methods, eardrum perforation closing rates, hearing improvement and future application of myringoplasty...
  72. ncbi Myringoplasty results in a district hospital in Botswana
    I K Denge Makaya
    Moi Teaching and Referral Hospital, Eldoret, Kenya
    Trop Doct 36:176-7. 2006
    ..There was a 62% positive change of more than 10 dB in the pure tone averages of air conduction at frequencies 500, 1000 and 2000 Hz and a 24% improvement of less than 10 dB. This compares favourably with results from other studies...
  73. ncbi Cross-linked hydrogels for middle ear packing
    Albert H Park
    Division of Otolaryngology Head and Neck Surgery, University of Utah, School of Medicine, Salt Lake City, Utah 84132, USA
    Otol Neurotol 27:1170-5. 2006
    ..To develop an ideal supportive packing material for ossiculoplasty, tympanoplasty, or other otologic procedures...
  74. ncbi The effects of the incision types in myringoplasty operations on cosmesis
    Berna Uslu Coskun
    Department of Otorhinolaryngology, Sisli Etfal Teaching and Training Hospital, Istanbul, Turkey
    Eur Arch Otorhinolaryngol 263:820-2. 2006
    ..In this study, esthetically better results were observed in the myringoplasty operations done by endaural incision than the ones done by postauricular incision. When deciding on the incision type, this should be considered...
  75. ncbi Butterfly cartilage graft inlay tympanoplasty for large perforations
    Marcielle A Ghanem
    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Laryngoscope 116:1813-6. 2006
    ..Butterfly graft inlay tympanoplasty is a well-established technique for the repair of small perforations. However, the efficacy of the technique for medium and large tympanic membrane perforations remains unknown...
  76. ncbi Meta-analysis of tympanostomy tube sequelae
    D J Kay
    Department of Otolaryngology, SUNY Health Science Center at Brooklyn, Brooklyn, New York, USA
    Otolaryngol Head Neck Surg 124:374-80. 2001
    ..Long-term tubes should be used on a selective and individualized basis...
  77. ncbi Correlation between middle-ear pressure-regulation functions and outcome of type-I tympanoplasty
    Haruo Takahashi
    Department of Otolaryngology, Head and Neck Surgery, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1 7 1, Nagasaki 852 8501, Japan
    Auris Nasus Larynx 34:173-6. 2007
    ..To examine the correlation between the middle-ear pressure-regulation functions including active eustachian tube (ET) functions and transmucosal gas exchange function, and outcome of tympanoplasty...
  78. ncbi Tympanometric volume: a predictor of success of tympanoplasty in children
    Daniel Merenda
    Department of Otolaryngology Head and Neck Surgery, West Virginia University, P O Box 9200, Morgantown, WV 26506 9200, USA
    Otolaryngol Head Neck Surg 136:189-92. 2007
    ..To determine if preoperative tympanometric volumes have any predictive value in the success of pediatric tympanoplasty...
  79. ncbi Revision chronic ear surgery
    David M Kaylie
    Otology Group of Vanderbilt, 300 20th Avenue North, Suite 502, Nashville, TN 37203, USA
    Otolaryngol Head Neck Surg 134:443-50. 2006
    ..To report results of revision chronic ear surgery following guidelines of the American Academy of Otolaryngology-Head and Neck Surgery and to establish expectations for infection and cholesteatoma control and hearing outcomes...
  80. ncbi Revision tympanoplasty using scar tissue graft
    Hamid R Djalilian
    Division of Otolarynology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Otol Neurotol 27:131-5. 2006
    ..To evaluate the success rate of subcutaneous postsurgical scar tissue as graft material for revision tympanoplasty operations...
  81. ncbi Prevalence of middle ear pathologies in children with bilateral sensorineural hearing loss
    Kamal Eldin Ahmed Abou-Elhamd
    Sohag Faculty of Medicine, Sohag, Egypt
    Int J Pediatr Otorhinolaryngol 70:1081-4. 2006
    ..These children may have middle ear problem, this will aggravate the level of hearing loss which may lead to delay in their ability to speak. This study is to highlight the prevalence of middle ear pathology in SNHL children...
  82. ncbi ["Ear camp" for children in Namibia. A field report]
    G Lehnerdt
    Universitäts Hals Nasen Ohren Klinik Essen, Universitatsklinikum Essen
    HNO 54:46-51. 2006
    ..Ear surgery is urgently needed in northern Namibia as many children cannot even be provided with hearing aids due to chronically discharging ears, not to forget possible complications of untreated cholesteatoma...
  83. ncbi Tri-adcortyl ointment ear dressing in myringoplasty: an analysis of outcome
    O Anderson
    Department of ENT, City Hospital, Dudley Road, Birmingham, B18 7QH, UK
    Eur Arch Otorhinolaryngol 264:873-7. 2007
    ..240), 91% for adult patients and 88% for children (P = 1.000). TAO is a suitable ear dressing in myringoplasty. Routine use of TAO did not affect the success rate of myringoplasty at our centre...
  84. ncbi [Tympanoplasty and mastoidectomy in patients with large perforation of tympanic membrane in pars tensa]
    Ruiming Xia
    Department of Otolaryngology, the People s Hospital of Peking University, Beijing, 100044, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 19:439-41. 2005
    ..To present the experiences of tympanoplasty in patients with large perforation of tympanic membrane in pars tensa...
  85. ncbi Chronic tympanic membrane perforation: middle ear pressure and tubal function
    M Brattmo
    Department of Otorhinolaryngology, University Hospital, Lund University, Malmo, Sweden
    Acta Otolaryngol 123:569-74. 2003
    ..To monitor the middle ear (ME) pressure continuously, day and night, in subjects with chronic central perforation (CCP) whose ears were temporarily sealed off from ambient air...
  86. ncbi Synchronous fat plug myringoplasty and tympanostomy tube removal in the management of refractory otorrhoea in younger patients
    L Liew
    Department of Otorhinolaryngology Head and Neck Surgery, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Int J Pediatr Otorhinolaryngol 66:291-6. 2002
    ..A synchronous fat plug myringoplasty was performed with tube removal in an attempt to reduce the residual perforation rate...
  87. ncbi A comparison of cartilage palisades and fascia in tympanoplasty after surgery for sinus or tensa retraction cholesteatoma in children
    Joanne Anderson
    Department of Otorhinolaryngology Head and Neck Surgery, Gentofte University Hospital, Hellerup, Denmark
    Otol Neurotol 25:856-63. 2004
    ....
  88. ncbi Allograft tympanoplasty
    T Somers
    University ENT Department, Sint Augustinus Hospital, Wilrijk Antwerp, Belgium
    Acta Otorhinolaryngol Belg 58:87-96. 2004
    ..The authors believe that the tympano-ossicular allograft is the material of choice in extensively diseased middle ears destroyed by chronic otitis media with or without cholesteatoma...
  89. ncbi Success of cartilage grafting in revision tympanoplasty without mastoidectomy
    Ryan T Boone
    Department of Otolaryngology Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Otol Neurotol 25:678-81. 2004
    ..Our objective was to assess outcomes in patients undergoing revision tympanoplasty without mastoidectomy using cartilage grafting...
  90. ncbi [Results of myringoplasty and type I tympanoplasty with the use of fascia, cartilage and perichondrium grafts]
    Tatiana Gierek
    Klinika Laryngologii Sl AM w Katowicach
    Otolaryngol Pol 58:529-33. 2004
    ..The comparison of operation results showed that there was no significant difference between the two groups...
  91. ncbi [An improved animal model for chronic perforation of the tympanic membrane]
    H Kaftan
    Klinik und Poliklinik für Hals Nasen Ohren Krankheiten, Kopf und Halschirurgie der Ernst Moritz Arndt Universität Greifswald
    HNO 52:714-9. 2004
    An inexpensive and valid animal model of chronic tympanic membrane perforation is needed.
  92. ncbi Adipose graft: an original option in myringoplasty
    S Ayache
    Otorhinolaryngology and Cervical and Facial Surgery Federation, La Timone Hospital, Marseille Cedex, France
    Otol Neurotol 24:158-64. 2003
    ..To describe the fat graft as a reconstructive material in myringoplasty...
  93. ncbi [Early postoperative middle-ear ventilation -- risk for the transplant or guarantee for aeration of the tympanic cavity?]
    A Dorrie
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde, Kopf und Halschirurgie, Otto Körner Universität Rostock
    Laryngorhinootologie 82:102-4. 2003
    ..However this implicates the risk of a dislocation of the transplant, which is possibly caused by high middle-ear pressure-peaks during the maneuvers mentioned...
  94. ncbi Anterosuperior anchoring myringoplasty technique for anterior and subtotal perforations
    T Hung
    Department of Otolaryngology, Mayday Hospital, Croydon, London, UK
    Clin Otolaryngol Allied Sci 29:210-4. 2004
    ..05), 2 kHz (P < 0.01) and 4 kHz (P < 0.01). Our study showed that the anterosuperior anchoring technique produced excellent results in the repair of challenging anterior and subtotal perforations in both adults and children...
  95. ncbi Lateralization of the tympanic membrane as a complication of canal wall down tympanoplasty: a report of four cases
    Kiyofumi Gyo
    Department of Otolaryngology, Ehime University, Onsen gun Shigenobu cho, Ehime, Japan
    Otol Neurotol 24:145-8. 2003
    ..To describe the pathophysiology and treatment of the lateralized tympanic membrane that occurs after canal wall down tympanoplasty...
  96. ncbi [The evaluation of cartilage and perichondrium grafts for the reconstruction of the tympanic membrane]
    Aleksandra Slaska-Kaspera
    Katedra i Klinika Laryngologii Sl AM w Katowicach
    Otolaryngol Pol 57:889-92. 2003
    ....
  97. ncbi Day-case myringoplasty: five years' experience
    A Karkanevatos
    J Laryngol Otol 117:763-5. 2003
    ..Myringoplasty can be safely performed in both adults and children as a day-case procedure with low overnight stay and readmission rates. Success rates are comparable to when the procedure is performed on an in-patient basis...
  98. ncbi Preliminary results with the use of AlloDerm in chronic otitis media
    Jose N Fayad
    Department of Otolaryngology Head and Neck Surgery, Columbia University College of Physicians and Surgeons, The New York Presbyterian Hospital, 180 Fort Washington Avenue, Harkness Pavilion, Suite 813, New York, NY 10032, USA
    Laryngoscope 113:1228-30. 2003
    ..AlloDerm, an acellular dermal graft, has been used successfully as a material for soft tissue implantation. The authors report their experience with the use of AlloDerm in the reconstruction of the tympanic membrane...
  99. ncbi The morphology of central tympanic membrane perforations
    A Nepal
    Department of Otolaryngology and Head and Neck Surgery, B P Koirala Institute of Health Sciences, Dharan, Nepal
    Nepal Med Coll J 9:239-44. 2007
    ..Hearing loss in the study was found to range from negligible to 53dB. Overall, perforations involving posterioinferior quadrant were found to have maximum hearing loss...
  100. ncbi Anterior transcanal tympanoplasty: a novel technique to repair anterior perforations
    Michael D Seidman
    Department of Otolaryngology Head and Neck Surgery, Henry Ford Health System, Bloomfield, MI 48322, USA
    Otolaryngol Head Neck Surg 138:242-5. 2008
    ..To report a novel, minimally invasive technique for anterior tympanic membrane (TM) perforation repair...
  101. ncbi Inlay butterfly cartilage tympanoplasty in children
    Vincent Couloigner
    Department of Pediatric Otolaryngology and Head and Neck Surgery, Hopital Robert Debre, AP HP, Paris, France
    Otol Neurotol 26:247-51. 2005
    ..To assess the results of inlay butterfly cartilage tympanoplasty in children...

Research Grants8

  1. Crosslinkable Hydrogels for Tympanic Membrane Repair
    Glenn Prestwich; Fiscal Year: 2004
    b>Tympanic membrane perforation (TMP, or "ruptured eardrum") is a common occurrence caused by trauma, ear infections, or pressure equalization tube insertion...
  2. Middle-ear assessment via reflectance measurements
    Susan Voss; Fiscal Year: 2005
    ..This work will both strengthen the research environment at Smith College and provide substantial research experiences for undergraduate students. ..
  3. Ear Biomechanics for Restoration of Hearing
    RONG GAN; Fiscal Year: 2009
    ..Thus, the results will be essential for improving the diagnosis of OME, assessing surgical treatment for conductive hearing loss, and potentially improve the quality of life for millions of people. ..
  4. EPIDEMIOLOGY OF OTITIS MEDIA IN NATIVE AMERICAN CHILDREN
    Kathleen Daly; Fiscal Year: 2001
    ..The ultimate goal is to decrease OM incidence and recurrence in Native American population. ..
  5. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
    ..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
  6. Otitis Media Core Center
    Kathleen Daly; Fiscal Year: 2005
    ..Together, the Cores will greatly enhance the OMRC infrastructure, allowing highly productive basic and clinical scientists to conduct research on a broad range of middle and inner ear disorders. ..
  7. Sustained Release Inner Ear Delivery of Corticosteroid
    William Slattery; Fiscal Year: 2007
    ..This system could also be used for other drugs where chronic delivery is essential. [unreadable] [unreadable] [unreadable]..
  8. GENETIC EPIDEMIOLOGY OF CHRONIC/RECURRENT OTITIS MEDIA
    KATHLEEN ANN DALY; Fiscal Year: 2010
    ..It is anticipated that this study will provide new insights into the gene-gene and gene- environment interactions that contribute to the development of COME/ROM in childhood. ..