otitis media

Summary

Summary: Inflammation of the middle ear.

Top Publications

  1. pmc New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
    Janet R Casey
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 29:304-9. 2010
  2. ncbi Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study
    Roman Prymula
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 367:740-8. 2006
  3. ncbi Efficacy of a pneumococcal conjugate vaccine against acute otitis media
    J Eskola
    National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:403-9. 2001
  4. ncbi Haemophilus influenzae: a significant pathogen in acute otitis media
    Eugene Leibovitz
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 23:1142-52. 2004
  5. doi Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, N C, USA
    J Innate Immun 1:215-24. 2009
  6. pmc Viral-bacterial interactions and risk of acute otitis media complicating upper respiratory tract infection
    Melinda M Pettigrew
    Yale School of Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Clin Microbiol 49:3750-5. 2011
  7. pmc Burden of disease caused by otitis media: systematic review and global estimates
    Lorenzo Monasta
    Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    PLoS ONE 7:e36226. 2012
  8. doi Acute otitis media: From diagnosis to prevention. Summary of the Italian guideline
    Paola Marchisio
    Department of Maternal and Pediatric Sciences, University of Milan and Foundation, IRCCS Cà Granda Ospedale Maggiore Policlinico, Italy
    Int J Pediatr Otorhinolaryngol 74:1209-16. 2010
  9. pmc Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media
    Ravinder Kaur
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, University of Rochester School of Medicine, Rochester, NY, USA
    Pediatr Infect Dis J 29:741-5. 2010
  10. pmc Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice
    Jennifer M Hilton
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 12:R90. 2011

Detail Information

Publications336 found, 100 shown here

  1. pmc New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
    Janet R Casey
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 29:304-9. 2010
    ..pneumococcal conjugate (PCV7) in the United States and to compare nasopharyngeal (NP) colonization and acute otitis media (AOM) microbiology in children 6 to 36 months of age having first and second AOM episodes with children who are ..
  2. ncbi Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study
    Roman Prymula
    Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 367:740-8. 2006
    Acute otitis media is one of the most commonly-diagnosed childhood infections...
  3. ncbi Efficacy of a pneumococcal conjugate vaccine against acute otitis media
    J Eskola
    National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:403-9. 2001
    ..New conjugate vaccines may be able to prevent a substantial portion of cases of acute otitis media caused by Streptococcus pneumoniae...
  4. ncbi Haemophilus influenzae: a significant pathogen in acute otitis media
    Eugene Leibovitz
    Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Pediatr Infect Dis J 23:1142-52. 2004
    Haemophilus influenzae is a major pathogen in acute otitis media (AOM) causing disease that is not clinically distinguishable from that caused by Streptococcus pneumoniae. AOM caused by H...
  5. doi Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, N C, USA
    J Innate Immun 1:215-24. 2009
    Nontypeable Haemophilus influenzae (NTHi) is a leading cause of acute and chronic otitis media, which are a major public health problem worldwide...
  6. pmc Viral-bacterial interactions and risk of acute otitis media complicating upper respiratory tract infection
    Melinda M Pettigrew
    Yale School of Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Clin Microbiol 49:3750-5. 2011
    Acute otitis media (AOM) is a common complication of upper respiratory tract infection whose pathogenesis involves both viruses and bacteria...
  7. pmc Burden of disease caused by otitis media: systematic review and global estimates
    Lorenzo Monasta
    Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    PLoS ONE 7:e36226. 2012
    b>Otitis media (OM) is a leading cause of health care visits and drugs prescription. Its complications and sequelae are important causes of preventable hearing loss, particularly in developing countries...
  8. doi Acute otitis media: From diagnosis to prevention. Summary of the Italian guideline
    Paola Marchisio
    Department of Maternal and Pediatric Sciences, University of Milan and Foundation, IRCCS Cà Granda Ospedale Maggiore Policlinico, Italy
    Int J Pediatr Otorhinolaryngol 74:1209-16. 2010
    Acute otitis media (AOM) is the most common disease occurring in infants and children and has major medical, social and economic effects...
  9. pmc Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media
    Ravinder Kaur
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, University of Rochester School of Medicine, Rochester, NY, USA
    Pediatr Infect Dis J 29:741-5. 2010
    The 3 most commonly encountered bacteria in acute otitis media (AOM) are Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Conventional culture methods detect these pathogens in only 60% to 70% of cases of AOM...
  10. pmc Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice
    Jennifer M Hilton
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Genome Biol 12:R90. 2011
    Inflammation of the middle ear (otitis media) is very common and can lead to serious complications if not resolved. Genetic studies suggest an inherited component, but few of the genes that contribute to this condition are known...
  11. pmc Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Infect Immun 75:958-65. 2007
    Nontypeable Haemophilus influenzae (NTHi) is a leading causative agent of otitis media. Much of the inflammation occurring during NTHi disease is initiated by lipooligosaccharides (LOS) on the bacterial surface...
  12. ncbi The burden of otitis media
    J O Klein
    Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, 774 Albany Street, Boston, MA 02118, USA
    Vaccine 19:S2-8. 2000
    b>Otitis media is the most frequent reason that children go to the doctor for illness...
  13. ncbi Community-wide vaccination with the heptavalent pneumococcal conjugate significantly alters the microbiology of acute otitis media
    Stan L Block
    Kentucky Pediatric Research, Inc, Bardstown, KY, USA
    Pediatr Infect Dis J 23:829-33. 2004
    ..use of conjugated heptavalent pneumococcal vaccine (PCV7) in children <2 years of age could affect the microbiology of acute otitis media (AOM) in vaccinees, particularly for penicillin-nonsusceptible Streptococcus pneumoniae (PNSP).
  14. pmc Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene
    Cong Tian
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 7:e34944. 2012
    b>Otitis media is a middle ear disease common in children under three years old...
  15. doi Impact of different case definitions for acute otitis media on the efficacy estimates of a pneumococcal conjugate vaccine
    Arto Palmu
    National Public Health Institute, Helsinki, Finland Tampere School of Public Health, Tampere, Finland
    Vaccine 26:2466-70. 2008
    Considerably higher vaccine efficacy estimate for clinical acute otitis media (AOM) has been obtained for the 11-valent pneumococcal conjugate vaccine with protein D of Haemophilus influenzae as a carrier (PncPD11) in the POET study than ..
  16. doi Dynamic of pneumococcal nasopharyngeal carriage in children with acute otitis media following PCV7 introduction in France
    R Cohen
    Departement de Microbiologie, Centre Hospitalier Intercommunal de Creteil, Service de Microbiologie, 40 avenue de Verdun, 94 000 Creteil, France
    Vaccine 28:6114-21. 2010
    ..3291 nasopharyngeal swabs were obtained between 2001 and 2006, from children aged 6-24 months with acute otitis media. Following the implementation of PCV7, we observed a slight reduction in the overall pneumococcal carriage, a ..
  17. doi The impact of the heptavalent pneumococcal conjugate vaccine on the epidemiology of acute otitis media complicated by otorrhea
    Kostantinos Stamboulidis
    Second Department of Pediatrics, P and A Kyriakou Children s Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece
    Pediatr Infect Dis J 30:551-5. 2011
    ..The aim of this observational hospital-based study was to examine the effect of the PCV7 (introduced in our settings in 2004) on the epidemiology of spontaneously draining acute otitis media.
  18. pmc High incidence of Alloiococcus otitidis in children with otitis media, despite treatment with antibiotics
    Atsushi Harimaya
    Department of Otolaryngology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    J Clin Microbiol 44:946-9. 2006
    Acute otitis media (AOM) and otitis media with effusion (OME) are common diseases in childhood. Alloiococcus otitidis is a newly recognized species of gram-positive bacterium which was recently discovered as a pathogen associated with OME...
  19. doi Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteria in Australian Aboriginal and non-Aboriginal children
    Peter Jacoby
    Centre for Child Health Research, Telethon Institute for Child Health Research, The University of Western Australia, Perth, Australia
    Pediatr Infect Dis J 30:480-5. 2011
    Streptococcus pneumoniae, Moraxella catarrhalis, and nontypeable Haemophilus influenzae is associated with otitis media (OM). Data are limited on risk factors for carriage of these pathogens, particularly for Indigenous populations...
  20. pmc Viral-bacterial co-infection in Australian Indigenous children with acute otitis media
    Michael J Binks
    Ear and Respiratory Unit, Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    BMC Infect Dis 11:161. 2011
    Acute otitis media with perforation (AOMwiP) affects 40% of remote Indigenous children during the first 18 months of life...
  21. doi Microbial interactions in the respiratory tract
    Timothy F Murphy
    Division of Infectious Diseases, The State University of New York, Buffalo, NY, USA
    Pediatr Infect Dis J 28:S121-6. 2009
    ..catarrhalis can behave as opportunistic pathogens of the middle ear when conditions are optimal. Chronic otitis media (OM) and recurrent OM include a biofilm component...
  22. pmc Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era
    Aarti Agrawal
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    J Clin Microbiol 49:3728-32. 2011
    ..H. influenzae causes predominantly mucosal infections. The introduction of vaccines for otitis media and global shifts in antimicrobial susceptibility emphasize the importance of continued surveillance of H...
  23. ncbi Otitis media
    Maroeska M Rovers
    Julius Centre for Health Sciences and Primary Care, University Medical Centre, PO Box 85060, 3508 AB, Utrecht, Netherlands
    Lancet 363:465-73. 2004
    b>Otitis media (OM) continues to be one of the most common childhood infections and is a major cause of morbidity in children...
  24. doi Otitis media and its consequences: beyond the earache
    Anne Vergison
    Universite Libre de Bruxelles, Brussels, Belgium
    Lancet Infect Dis 10:195-203. 2010
    ..on middle-ear and paediatric infections met to explore where consensus exists on the management of acute otitis media. After informal discussions among several specialists of paediatric infectious disease, the group was expanded ..
  25. ncbi Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group
    S Black
    Kaiser Permanente Vaccine Study Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 19:187-95. 2000
    ..safety and immunogenicity of the heptavalent CRM197 pneumococcal conjugate vaccine against invasive disease caused by vaccine serotypes and to determine the effectiveness of this vaccine against clinical episodes of otitis media.
  26. ncbi Nasopharyngeal carriage of Streptococcus pneumoniae in Finnish children younger than 2 years old
    R K Syrjänen
    Department of Vaccines, National Public Health Institute KTL, Helsinki, Finland
    J Infect Dis 184:451-9. 2001
    ..the natural course of nasopharyngeal carriage of Streptococcus pneumoniae and its relationship to acute otitis media (AOM), 329 Finnish children were followed from ages 2 to 24 months...
  27. doi The burden of otitis media
    Maroeska M Rovers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Vaccine 26:G2-4. 2008
    b>Otitis media (OM) is one of the most frequent diseases in young children, one of the most common reasons for a child to visit a physician, and also the most common indication for antibiotic prescribing...
  28. pmc Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20
    Alistair Harrison
    Center for Microbial Pathogenesis, Columbus Children s Research Institute, Ohio State University College of Medicine and Public Health, Columbus, Ohio 43205, USA
    J Bacteriol 187:4627-36. 2005
    ..In contrast, strains of nontypeable H. influenzae are the primary pathogens of chronic and recurrent otitis media in children...
  29. pmc Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings
    Carlos G Grijalva
    Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Ave, Ste 2600, The Village at Vanderbilt, Nashville, TN 37232 2637, USA
    JAMA 302:758-66. 2009
    ..During the 1990s, antibiotic prescriptions for acute respiratory tract infection (ARTI) decreased in the United States. The sustainability of those changes is unknown...
  30. doi Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review
    Tumaini R Coker
    Department of Pediatrics, Mattel Children s Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California 90024, USA
    JAMA 304:2161-9. 2010
    Acute otitis media (AOM) is the most common condition for which antibiotics are prescribed for US children; however, wide variation exists in diagnosis and treatment.
  31. ncbi Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media
    Daniel J Morton
    Department of Pediatrics, University of Oklahoma Health Sciences Center, CHO 2308, 940 NE 13th Street, Oklahoma City, OK 73104, USA
    Microb Pathog 36:25-33. 2004
    ..hgp genes was constructed and compared to the wild-type strain in a chinchilla (Chinchilla lanigera) model of otitis media. Compared to the wild-type strain, the hgp-deficient mutant exhibited a significantly delayed onset of ..
  32. ncbi Bacterial otitis media: a vaccine preventable disease?
    Allan W Cripps
    School of Medicine, Griffith University, Gold Coast Campus, PMB 50, Gold Coast MC, QLD 9726, Australia
    Vaccine 23:2304-10. 2005
    b>Otitis media (OM) is the most common childhood illness for which medical advice is sought. Whilst the disease rarely results in death, there is a significant level of morbidity and economic burden on the community...
  33. doi The incidence of Streptococcus pneumoniae otitis media is affected by the polymicrobial environment particularly Moraxella catarrhalis in a mouse nasal colonisation model
    Ajay Krishnamurthy
    Capricornia Centre for Mucosal Immunology, CQUniversity, Queensland, Australia
    Microbes Infect 11:545-53. 2009
    b>Otitis media (OM) is a highly prevalent paediatric disease with both bacterial and viral triggers of infection...
  34. pmc Sh3pxd2b mice are a model for craniofacial dysmorphology and otitis media
    Bin Yang
    Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e22622. 2011
    ..These defects can lead to an increased incidence of otitis media. We examined the effects of a mutation in the Sh3pxd2b gene (Sh3pxd2b(nee)) on the progression of otitis media ..
  35. pmc Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood
    Marie S Rye
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Subiaco, Australia
    PLoS ONE 7:e48215. 2012
    b>Otitis media (OM) is a common childhood disease characterised by middle ear inflammation and effusion...
  36. pmc Neutrophil extracellular traps and bacterial biofilms in middle ear effusion of children with recurrent acute otitis media--a potential treatment target
    Ruth B Thornton
    School of Paediatrics and Child Health, The University of Western Australia, Perth, Australia
    PLoS ONE 8:e53837. 2013
    Bacteria persist within biofilms on the middle ear mucosa of children with recurrent and chronic otitis media however the mechanisms by which these develop remain to be elucidated...
  37. ncbi Otitis media
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, NY 14642, USA
    Expert Opin Pharmacother 3:1073-90. 2002
    Bacterial pathogens are isolated from middle ear fluid in up to 90% of children with acute otitis media (OM). Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis predominate...
  38. pmc Expression of cytokine genes during pneumococcal and nontypeable Haemophilus influenzae acute otitis media in the rat
    A Melhus
    Department of Surgery Otolaryngology, University of California at San Diego School of Medicine and Veterans Affairs Medical Center, La Jolla, California, USA
    Infect Immun 68:4024-31. 2000
    Acute otitis media (AOM) elicits potent inflammatory responses from the cells of the middle ear mucosa as well as from infiltrating leukocytes...
  39. pmc A novel group of Moraxella catarrhalis UspA proteins mediates cellular adhesion via CEACAMs and vitronectin
    Darryl J Hill
    School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 7:e45452. 2012
    Moraxella catarrhalis (Mx) is a common cause of otitis media and exacerbation of chronic obstructive pulmonary disease, an increasing worldwide problem...
  40. doi Nasopharyngeal microbiota in infants with acute otitis media
    Markus Hilty
    Institute for Infectious Diseases, University of Berne, Berne, Switzerland
    J Infect Dis 205:1048-55. 2012
    ..Interspecies interactions of the nasopharyngeal microbiota are likely to be involved in the pathogenesis of acute otitis media (AOM)...
  41. pmc Nontypeable Streptococcus pneumoniae as an otopathogen
    Qingfu Xu
    Rochester General Hospital Research Institute, Rochester, NY 14621, USA
    Diagn Microbiol Infect Dis 69:200-4. 2011
    ..pneumoniae (NT-Spn) in a child with acute otitis media (AOM). The strain was pneumolysin PCR positive and capsule gene PCR negative...
  42. pmc Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media
    Stephanie Kuhn
    Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 7:e31433. 2012
    ..the most common congenital disorders leading to a wide range of health problems in humans, including frequent otitis media. The Tc1 mouse carries a significant part of human chromosome 21 (Hsa21) in addition to the full set of mouse ..
  43. doi Burden of otitis media and pneumonia in children up to 6 years of age: results of the LISA birth cohort
    Eva Schnabel
    Institute of Epidemiology, Helmholtz Zentrum Munich, Center for Environment and Health, 85764 Neuherberg, Germany
    Eur J Pediatr 168:1251-7. 2009
    ..For Germany, few data are available on the epidemiology of infectious diseases such as otitis media and pneumonia in children...
  44. doi The diagnosis and management of acute otitis media
    Allan S Lieberthal
    American Academy of Pediatrics and American Academy of Family Physicians
    Pediatrics 131:e964-99. 2013
    This evidence-based clinical practice guideline is a revision of the 2004 acute otitis media (AOM) guideline from the American Academy of Pediatrics (AAP) and American Academy of Family Physicians...
  45. doi Prevalence of pilus-encoding islets among acute otitis media Streptococcus pneumoniae isolates from Israel
    M Moschioni
    Novartis Vaccines and Diagnostics Srl, Research Center, Siena, Italy
    Clin Microbiol Infect 16:1501-4. 2010
    ..of the two known Streptococcus pneumoniae pilus encoding islets (PI-1 and PI-2) among a panel of 113 acute otitis media clinical isolates from Israel. PI-1 was present in 30...
  46. doi Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention
    Lauren O Bakaletz
    The Research Institute at Nationwide Children s Hospital, Center for Microbial Pathogenesis, and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA
    Expert Rev Vaccines 8:1063-82. 2009
    ..For the highly prevalent pediatric disease otitis media, or middle-ear infection, the chinchilla (Chinchilla lanigera) has served as a gold-standard rodent host system ..
  47. ncbi Trends in otitis media among children in the United States
    Peggy Auinger
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry and the American Academy of Pediatrics Center for Child Health Research, Rochester, New York 14620, USA
    Pediatrics 112:514-20. 2003
    The prevalence of repeated otitis media (OM) increased during the 1980s, but it is unknown if the increase has continued.
  48. ncbi National impact of universal childhood immunization with pneumococcal conjugate vaccine on outpatient medical care visits in the United States
    Carlos G Grijalva
    Department of Preventive Medicine, Division of Pharmacoepidemiology, Vanderbilt University School of Medicine, Nashville, TN 37232 2637, USA
    Pediatrics 118:865-73. 2006
    ..However, the national impact of heptavalent pneumococcal conjugate vaccine on pneumonia and otitis media remains unknown.
  49. doi How to compare the efficacy of conjugate vaccines to prevent acute otitis media?
    Philippe De Wals
    Department of Social and Preventive Medicine, Laval University, Pavillon de l Est, 2180 chemin Sainte Foy, Suite 1108, Quebec City, Canada G1K 7P4
    Vaccine 27:2877-83. 2009
    ..for the prevention of invasive pneumococcal disease, it has also demonstrated the potential to prevent acute otitis media (AOM) and its associated complications...
  50. pmc Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children
    Ravinder Kaur
    Rochester General Hospital Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY 14621, USA
    Pediatr Infect Dis J 30:645-50. 2011
    Streptococcus pneumoniae (Spn) is one of the common bacteria responsible for episodic acute otitis media (AOM; non-otitis-prone), recurrent AOM (otitis-prone), and AOM treatment failure (AOMTF) in children.
  51. doi Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease
    Yukiko Iino
    Department of Otolaryngology, Jichi Medical University, Saitama Medical Center, Omiya ku, Japan
    Auris Nasus Larynx 38:456-61. 2011
    Eosinophilic otitis media (EOM) is a newly recognized intractable middle ear disease, characterised by the accumulation of eosinophils in middle ear effusion and middle ear mucosa...
  52. pmc A functional tonB gene is required for both virulence and competitive fitness in a chinchilla model of Haemophilus influenzae otitis media
    Daniel J Morton
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    BMC Res Notes 5:327. 2012
    ..Haemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient...
  53. doi Efficacy of pneumococcal vaccination in children younger than 24 months: a meta-analysis
    Maria Pavia
    Department of Hygiene, Medical School, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Pediatrics 123:e1103-10. 2009
    ..Pneumococcal conjugate bacterial vaccines that are able to prevent invasive disease and mucosal infections have been developed...
  54. pmc Inactivation of Chibby affects function of motile airway cilia
    Vera A Voronina
    Department of Pharmacology, Howard Hughes Medical Institute, USA
    J Cell Biol 185:225-33. 2009
    ..As the phenotypes of Cby(-/-) mice bear striking similarities to primary ciliary dyskinesia, Cby(-/-) mice may prove to be a useful model for this condition...
  55. ncbi Survival of nontypeable Haemophilus influenzae in macrophages
    J E Craig
    University of Manchester, School of Biological Sciences, 1.800, Stopford Building, Manchester M13 9PT, UK
    FEMS Microbiol Lett 203:55-61. 2001
    ..influenzae, 33 primary clinical isolates obtained from children with otitis media were screened for their ability to survive in macrophages...
  56. ncbi Systematic literature review of modifiable risk factors for recurrent acute otitis media in childhood
    José Faibes Lubianca Neto
    Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Porto Alegre, RS, Brazil
    J Pediatr (Rio J) 82:87-96. 2006
    Review evidence about modifiable risk factors for recurrent acute otitis media.
  57. pmc Role of complement in host defense against pneumococcal otitis media
    Vishakha Sabharwal
    Section of Pediatric Infectious Diseases, Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston, Massachusetts 02118, USA
    Infect Immun 77:1121-7. 2009
    ..of the same serotype (6A) and their capacity to cause nasopharyngeal (NP) colonization and experimental otitis media (EOM) in an animal model...
  58. doi Nontypeable Haemophilus influenzae as a pathogen in children
    Timothy F Murphy
    University at Buffalo, The State University of New York, Buffalo, NY
    Pediatr Infect Dis J 28:43-8. 2009
    Nontypeable Haemophilus influenzae is a significant pathogen in children, causing otitis media, sinusitis, conjunctivitis, pneumonia, and occasionally invasive infections. H...
  59. pmc Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media
    Luanne Hall-Stoodley
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA 15212, USA
    JAMA 296:202-11. 2006
    Chronic otitis media (OM) is a common pediatric infectious disease...
  60. ncbi Impact of the pneumococcal conjugate vaccine on otitis media
    Bruce Fireman
    Kaiser Permanente Division of Research and the Kaiser Permanente Vaccine Studies Center, Oakland, CA 94612, USA
    Pediatr Infect Dis J 22:10-6. 2003
    ..The heptavalent pneumococcal conjugate vaccine (PCV) is recommended for infants to protect against invasive disease, but its impact on otitis might also have public health importance...
  61. pmc A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media
    Kevin M Mason
    Department of Pediatrics, Center for Microbial Pathogenesis, Columbus Children s Research Institute, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205 2696, USA
    Infect Immun 73:599-608. 2005
    ..is upregulated in the middle ear in a chinchilla model of nontypeable Haemophilus influenzae (NTHI)-induced otitis media. Based on these findings, we constructed an NTHI strain containing a Lux reporter plasmid driven by the sapA ..
  62. ncbi Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices
    R Schmidt-Ullrich
    Max Delbrück Center of Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Development 128:3843-53. 2001
    ..Furthermore, NF-kappaB is required for peripheral lymph node formation and macrophage function...
  63. doi Global serotype distribution among Streptococcus pneumoniae isolates causing otitis media in children: potential implications for pneumococcal conjugate vaccines
    Gail L Rodgers
    Scientific Affairs and Global Medical Affairs, Vaccines, Wyeth Pharmaceuticals Inc, Collegeville, PA 19426, USA
    Vaccine 27:3802-10. 2009
    Acute otitis media (AOM) is the most common infection following pneumococcal colonization of the upper respiratory tract. Streptococcus pneumoniae causes 30-60% of AOM cases worldwide...
  64. ncbi Introduction and proliferation of multidrug-resistant Streptococcus pneumoniae serotype 19A clones that cause acute otitis media in an unvaccinated population
    Ron Dagan
    Pediatric Infectious Disease Unit, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Infect Dis 199:776-85. 2009
    ..A causative role of PCV7 was speculated. We prospectively studied the dynamics of acute otitis media (AOM) caused by Sp19A in southern Israel before the introduction of PCV7.
  65. doi Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule
    Selma P Wiertsema
    School of Paediatrics and Child Health, The University of Western Australia, 35 Stirling Highway, WA 6009, Perth, Australia
    Vaccine 29:5163-70. 2011
    ..Information on bacterial carriage and the aetiology of recurrent acute otitis media (rAOM) after introduction of PCV7 using the 3+0 schedule is required to evaluate the potential impact of second ..
  66. doi Epidemiology, natural history, and risk factors: panel report from the Ninth International Research Conference on Otitis Media
    Kathleen A Daly
    Department of Otolaryngology and Division of Epidemiology, University of Minnesota, Minneapolis, MN 55435, USA
    Int J Pediatr Otorhinolaryngol 74:231-40. 2010
    The 2007 Recent Advances in Otitis Media Research Conference Panel Report provides an update on otitis media (OM) research published from 2003 to 2007...
  67. pmc Phosphorylcholine expression by nontypeable Haemophilus influenzae correlates with maturation of biofilm communities in vitro and in vivo
    Wenzhou Hong
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, 5101A Gray Building, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Bacteriol 189:8300-7. 2007
    ..In vivo infection studies using the chinchilla model of otitis media showed a direct correlation between PCho expression and biofilm formation within the middle-ear chamber and an ..
  68. pmc Bacterial sinusitis and otitis media following influenza virus infection in ferrets
    Ville T Peltola
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    Infect Immun 74:2562-7. 2006
    Streptococcus pneumoniae is the leading cause of otitis media, sinusitis, and pneumonia. Many of these infections result from antecedent influenza virus infections...
  69. ncbi The efficacy of influenza vaccine for healthy children: a meta-analysis evaluating potential sources of variation in efficacy estimates including study quality
    Lamberto Manzoli
    Section of Epidemiology and Public Health, Department of Medicine and Aging Sciences, University G D Annunzio, Chieti, Italy
    Pediatr Infect Dis J 26:97-106. 2007
    ....
  70. pmc Role for Toll-like receptor 2 in the immune response to Streptococcus pneumoniae infection in mouse otitis media
    Fengchan Han
    Department of Otolaryngology HNS, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Infect Immun 77:3100-8. 2009
    Streptococcus pneumoniae is the most common pathogen associated with otitis media. To examine the role of Toll-like receptor 2 (TLR2) in host defense against Streptococcus pneumoniae infection in the middle ear, wild-type (WT; C57BL/6) ..
  71. pmc Sialylation of lipooligosaccharides promotes biofilm formation by nontypeable Haemophilus influenzae
    W Edward Swords
    Department of Microbiology and Immunology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Infect Immun 72:106-13. 2004
    ..Haemophilus influenzae (NTHi) is a major cause of opportunistic respiratory tract infections, including otitis media and bronchitis...
  72. pmc Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection
    L O Bakaletz
    Division of Otologic Research, Department of Otolaryngology, College of Medicine, The Ohio State University, Columbus, Ohio, USA
    Infect Immun 67:2746-62. 1999
    ..outer membrane proteins or their derivatives for their relative protective efficacy in chinchilla models of otitis media. Initial screening of these antigens (P5-fimbrin, lipoprotein D, and P6), delivered singly or in combination ..
  73. doi Acute otitis media caused by Moraxella catarrhalis: epidemiologic and clinical characteristics
    Arnon Broides
    Pediatric Immunology Clinic, Pediatric Emergency Department, Soroka University Medical Center, Beer Sheva, Israel
    Clin Infect Dis 49:1641-7. 2009
    This study describes the epidemiologic, microbiologic, and otologic features and selected signs and symptoms of acute otitis media (AOM) caused by Moraxella catarrhalis and compares them with AOM caused by other bacterial pathogens.
  74. ncbi Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media
    Marieke Emonts
    Department of Pediatrics, Erasmus MC Sophia Children s Hospital, University Medical Center, Dr Molewaterplein 50, Room Ee15 02, 3015 GE, Rotterdam, The Netherlands
    Pediatrics 120:814-23. 2007
    Cytokines and other inflammatory mediators are involved in the pathogenesis of otitis media. We hypothesized that polymorphisms in inflammatory response genes contribute to the increased susceptibility to acute otitis media in otitis-..
  75. pmc Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of pili
    Timothy F Murphy
    Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, USA
    BMC Microbiol 2:7. 2002
    Nontypeable Haemophilus influenzae is an important cause of otitis media in children and lower respiratory tract infection in adults with chronic obstructive pulmonary disease (COPD)...
  76. ncbi The heritability of otitis media: a twin and triplet study
    M L Casselbrant
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, PA 15213, USA
    JAMA 282:2125-30. 1999
    Anatomical, physiological, and epidemiological data indicate that there may be a significant genetic component to prolonged time with and recurrent episodes of otitis media in children.
  77. ncbi Antimicrobial treatment guidelines for acute bacterial rhinosinusitis
    Jack B Anon
    University of Pittsburgh, School of Medicine, USA
    Otolaryngol Head Neck Surg 130:1-45. 2004
  78. ncbi The microbiologic and immunologic basis for recurrent otitis media in children
    H Faden
    Division of Infectious Diseases, Children s Hospital of Buffalo, 219 Bryant St, Buffalo, New York 14222, USA
    Eur J Pediatr 160:407-13. 2001
    b>Otitis media is very common in children. A subpopulation of children, representing 5-10% of the general population, are otitis prone and they experience 4 or more episodes of acute otitis media (AOM) in the first year of life...
  79. pmc Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media
    Kevin M Mason
    Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus 43205, USA
    Infect Immun 71:3454-62. 2003
    The gram-negative bacterium nontypeable Haemophilus influenzae (NTHI) is the predominant pathogen in chronic otitis media with effusion and, with Streptococcus pneumoniae and Moraxella catarrhalis, is a causative agent of acute otitis ..
  80. pmc Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus
    Negin Gitiban
    Columbus Children s Research Institute, Rm W591, The Ohio State University College of Medicine and Public Health, Department of Pediatrics, 700 Children s Drive, Columbus, OH 43205 2696, USA
    J Virol 79:6035-42. 2005
    ..to RSV, recent literature suggests that RSV is the predominant viral pathogen predisposing to bacterial otitis media (OM). Herein, we describe mouse and chinchilla models of RSV infection of the nasopharynx and Eustachian tube...
  81. ncbi Protective efficacy of a second pneumococcal conjugate vaccine against pneumococcal acute otitis media in infants and children: randomized, controlled trial of a 7-valent pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate v
    Terhi Kilpi
    National Public Health Institute KTL, Helsinki, Finland
    Clin Infect Dis 37:1155-64. 2003
    ..polysaccharide-meningococcal outer membrane protein complex conjugate vaccine (PncOMPC) against acute otitis media (AOM), 1666 infants were randomly assigned to receive either PncOMPC or control vaccine (hepatitis B vaccine) ..
  82. ncbi Epidemiology of acute otitis media caused by Streptococcus pneumoniae before and after licensure of the 7-valent pneumococcal protein conjugate vaccine
    M Catherine McEllistrem
    Division of Infectious Diseases, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 15213 2582, USA
    J Infect Dis 188:1679-84. 2003
    ..protein 2b amplicon-restriction profiles, pneumococcal isolates recovered from children with acute otitis media during 1 January-31 December 1999 and 2001. The proportion of nonvaccine serogroups increased from 14...
  83. ncbi Respiratory infections caused by non-typeable Haemophilus influenzae
    Timothy F Murphy
    Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Curr Opin Infect Dis 16:129-34. 2003
    ..In addition, newer developments in the areas of mechanisms of pathogenesis, host pathogen interaction, immune responses and efforts toward vaccine development will be reviewed briefly...
  84. pmc Cochlear implantation in patients with chronic otitis media: 7 years' experience in Maastricht
    Job T F Postelmans
    Department of Otolaryngology, Maastricht University Medical Centre, The Netherlands
    Eur Arch Otorhinolaryngol 266:1159-65. 2009
    The purpose of this paper is to propose management options for cochlear implantation in chronic otitis media (COM) based on our 7-year experience. Thirteen patients with COM who were candidates for cochlear implantation were identified...
  85. ncbi Cochlear implantation in patients with a history of chronic otitis media
    Chong Sun Kim
    College of Medicine, Seoul National University, South Korea
    Acta Otolaryngol 124:1033-8. 2004
    To propose management options for cochlear implantation in chronic otitis media based on our experiences.
  86. ncbi Day-care and otitis media in young children: a critical overview
    M M Rovers
    Department of Otorhinolaryngology, University Hospital, Nijmegen, The Netherlands
    Eur J Pediatr 158:1-6. 1999
    To review the evidence concerning the association between (different forms of) day-care and otitis media in children aged 0-4 years, we performed a meta-analysis of studies identified by a systematic search with Medline from 1966 to July ..
  87. pmc Mcph1-deficient mice reveal a role for MCPH1 in otitis media
    Jing Chen
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 8:e58156. 2013
    b>Otitis media is a common reason for hearing loss, especially in children. Otitis media is a multifactorial disease and environmental factors, anatomic dysmorphology and genetic predisposition can all contribute to its pathogenesis...
  88. pmc Immunopathogenesis of polymicrobial otitis media
    Lauren O Bakaletz
    The Research Institute at Nationwide Children s Hospital, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, Columbus, OH 43205 2696, USA
    J Leukoc Biol 87:213-22. 2010
    ....
  89. doi Effects of amoxicillin treatment on the salivary microbiota in children with acute otitis media
    V Lazarevic
    Division of Infectious Diseases, Genomic Research Laboratory, Geneva University Hospitals, Geneva, Switzerland
    Clin Microbiol Infect 19:E335-42. 2013
    Amoxicillin is a first-line antibiotic treatment for acute otitis media in children and one of the most commonly used antibiotics for human bacterial infections...
  90. ncbi Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reaction
    A Pitkaranta
    Department of Medicine, University of Virginia, Health Sciences Center, Charlottesville, Virginia 22908, USA
    Pediatrics 102:291-5. 1998
    To determine the frequencies of human rhinovirus (HRV), respiratory syncytial virus (RSV), and coronavirus (HCV) infection in children with acute otitis media (AOM).
  91. pmc Association between cytokine gene polymorphisms and risk for upper respiratory tract infection and acute otitis media
    Krystal Revai
    Department of Pediatrics, University of Texas Medical Branch at Galveston, Texas, USA
    Clin Infect Dis 49:257-61. 2009
    ..Acute otitis media occurs most commonly as a complication of upper respiratory tract infection (URI); it is not clear why some ..
  92. pmc Influenza-induced inflammation drives pneumococcal otitis media
    Kirsty R Short
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia
    Infect Immun 81:645-52. 2013
    ..Infections may manifest as pneumonia, sepsis, meningitis, or otitis media (OM)...
  93. ncbi Genetic susceptibility to otitis media
    Margaretha L Casselbrant
    ENT Research Center, Children s Hospital of Pittsburgh, Pennsylvania, USA
    Curr Opin Allergy Clin Immunol 5:1-4. 2005
    b>Otitis media is a disease that is prevalent in the pediatric population, and recent twin and triplet studies have confirmed that there is a strong genetic component to susceptibility...
  94. ncbi Epidemiologic study of conjunctivitis-otitis syndrome
    Edouard Bingen
    Service de Microbiologie, Hopital Robert Debre, Paris, France
    Pediatr Infect Dis J 24:731-2. 2005
    ..throat specialists in the Paris area recruited 2901 children from 6 to 36 months of age presenting with acute otitis media, of whom 465 (16%) also had purulent conjunctivitis...
  95. pmc Viral-bacterial interactions in acute otitis media
    Tal Marom
    Division of Infectious Diseases, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555 0371, USA
    Curr Allergy Asthma Rep 12:551-8. 2012
    Acute otitis media (AOM) is a polymicrobial disease, which usually occurs as a complication of viral upper respiratory tract infection (URI)...
  96. doi Otitis media across nine countries: disease burden and management
    A Arguedas
    Instituto de Atención Pediátrica and Universidad de Ciencias Médicas, PO Box 607 1150 La Uruca, San Jose, Costa Rica
    Int J Pediatr Otorhinolaryngol 74:1419-24. 2010
    To assess the perceived disease burden and management of otitis media (OM) among an international cohort of experienced physicians.
  97. doi Cochlear implantation in atelectasis and chronic otitis media: long-term follow-up
    John Xenellis
    ENT Department, Athens University, Ippokratio, Greece
    Otol Neurotol 29:499-501. 2008
    To report the long-term results of cochlear implantation in cases with chronic otitis media or atelectasis using a single surgical technique performed in a single cochlear implant center.
  98. doi Epidemiology of acute otitis media in children of Latin America and the Caribbean: a systematic review and meta-analysis
    Ariel Bardach
    Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina
    Int J Pediatr Otorhinolaryngol 75:1062-70. 2011
    Acute otitis media (AOM) is one of the most common childhood diseases requiring antimicrobial prescription in pre-school children...
  99. doi The role of periostin in eosinophilic otitis media
    Hisanori Nishizawa
    Department of Otorhinolaryngology, Hirosaki University Graduate School of Medicine, Japan
    Acta Otolaryngol 132:838-44. 2012
    We investigated the localization of periostin in middle ear specimens from patients with eosinophilic otitis media (EOM) and from a newly constructed animal model for EOM...
  100. doi Referrals for recurrent respiratory tract infections including otitis media in young children
    Alma C van de Pol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Int J Pediatr Otorhinolaryngol 77:906-10. 2013
    ....
  101. pmc Upper respiratory tract microbial communities, acute otitis media pathogens, and antibiotic use in healthy and sick children
    Melinda M Pettigrew
    Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA
    Appl Environ Microbiol 78:6262-70. 2012
    ..of the upper respiratory tract microbial community may influence the risk for colonization by the acute otitis media (AOM) pathogens Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis...

Research Grants75

  1. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..Its subsequent spread to other sites frequently causes disease including otitis media, exacerbations of chronic obstructive pulmonary disease, and community acquired pneumonia...
  2. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..bacteria and paramyxoviruses are a significant factor in human patients with chronic bronchitis, sinusitis and otitis media. Sequelae of recurrent otitis media include hearing and speech impairment that significantly impact the quality ..
  3. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2011
    ..of 1 year of mentored research for the development of a career in microbial pathogenesis as it relates to otitis media (OM), followed by 3 years of independent research in the same discipline...
  4. Insights from Comparative Genomics for the Treatment of Pneumococcal Infections
    Natalia Luisa Hiller; Fiscal Year: 2013
    ..of 1 year of mentored research for the development of a career in microbial pathogenesis as it relates to otitis media (OM), followed by 3 years of independent research in the same discipline...
  5. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..Xylitol has been shown to prevent progression of dental caries, and decrease the incidence of acute otitis media. These studies raise an intriguing possibility: inhaled xylitol could enhance airway antibacterial defenses, ..
  6. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    ..Haemophilus influenzae inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis...
  7. Moraxella catarrhalis: virulence-based prevention
    Timothy F Murphy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Moraxella catarrhalis is an important cause of otitis media in children, and lower respiratory tract infections (exacerbations) in adults with chronic obstructive pulmonary disease (COPD)...
  8. Antimicrobial Peptides and Innate Immunity in Otitis Media
    Lauren O Bakaletz; Fiscal Year: 2012
    ..plays an active role in maintenance of the health of the middle ear, and is also actively engaged during otitis media (OM)...
  9. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    ..a pathogen, it spreads to the lungs (pneumonia), the central nervous system (meningitis), and the middle ear (otitis media). Mortality and morbidity due to S. pneumoniae is seen primarily in the very young and elderly...
  10. Haemophilus influenzae iron/heme regulon
    Terrence L Stull; Fiscal Year: 2012
    ..However, they provide no protection against nontypable strains which remain a common cause of otitis media, the most common infection of childhood, and pneumonia. H...
  11. Novel immunotherapeutics for the management of otitis media due to H. influenzae
    Steven D Goodman; Fiscal Year: 2013
    ..provided by applicant): There have been tremendous recent advances in our understanding of the pathogenesis of otitis media (OM) due to nontypeable Haemophilus influenzae (NTHI)...
  12. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    Over one-quarter of all oral antibiotics prescribed in the United States are for acute otitis media. Tympanostomy tube (TT) insertion has become the treatment of choice for children with recurrent or chronic otitis media, with more than ..
  13. Otitis media-associated pneumococcal genes
    Honggao Yan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM) accounts for most bacterial respiratory infections in children in both developed and developing nations...
  14. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Little is known of the inflammatory mechanisms of chronic otitis media that lead to inner ear pathology...
  15. For Hearing Component in the Hispanic Community Health Study (HCHS)
    Lisa Lavange; Fiscal Year: 2009
    ..Asthma appears to be a particular problem in some Hispanic subgroups, and chronic otitis media is increased among Hispanic children studied in the National Health and Nutrition Examination Survey (NHANES)...
  16. H. influenzae: Role of Sialic Acid in Virulence
    Michael A Apicella; Fiscal Year: 2013
    ..resistant phenotype appears to be a prerequisite for NTHi to initiate systemic infection (acute bronchitis, otitis media, etc)...
  17. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..Nontypable Haemophilus influenzae is a common cause of localized respiratory tract disease, especially otitis media, sinusitis, pneumonia, and exacerbations of chronic lung disease...
  18. A+ Head Start Intervention for Smoke Free Homes
    Cynthia S Rand; Fiscal Year: 2012
    ..respiratory health and has been clearly linked to increased risk of asthma, bronchitis, wheeze and otitis media. ETS exposure is higher in households at or below poverty level and this same population has also been found to ..
  19. DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIA
    Lauren O Bakaletz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM), or middle ear infection, is a highly prevalent pediatric disease worldwide, ranking first in reasons why children make physician's office and emergency room visits, undergo ..
  20. H. influenzae: Role of Sialic Acid in Virulence
    Michael Apicella; Fiscal Year: 2009
    ..resistant phenotype appears to be a prerequisite for NTHi to initiate systemic infection (acute bronchitis, otitis media, etc)...
  21. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    ..Haemophilus influenzae inhabits the human nasopharynx and conjunctiva, and can disseminate to cause pneumonia, otitis media, or meningitis...
  22. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
    ..provided by applicant): The long-term goal of the proposed research is to develop diagnostic tools for otitis media (OM) and other pneumococcal infections and research tools for studying pneumococcal pathogenesis...
  23. The Role of Eya4 in Hearing and Disease
    Jonathan G Seidman; Fiscal Year: 2010
    ..In addition, Eya4-/- mice uniformly develop middle ear effusions and purulent otitis media by 6 weeks of age;neither occurs in wildtype or Eya4+/- mice...
  24. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..demonstration will focus on two increasingly prevalent diseases encountered in the primary care office, namely otitis media (middle ear infections) and diabetic retinopathy...
  25. Heme, Iron and Oxidative Stress: Regulation of Iron Homeostasis in H. Influenzae
    Robert S Munson; Fiscal Year: 2013
    ..applicant): Nontypeable Haemophilus influenzae (NTHi) is a significant human pathogen as it is a major cause of otitis media (OM), sinusitis, exacerbations of chronic obstructive pulmonary disease (COPD) and bronchitis...
  26. H. influenzae Genes Associated with Acute Otitis Media
    Janet R Gilsdorf; Fiscal Year: 2010
    Acute otitis media results from a complex interplay of host defenses, environmental factors, and virulence characteristics of bacteria...
  27. Middle-ear Mechanics in Normal and Pathological Ears
    John J Rosowski; Fiscal Year: 2013
    ..Middle ear diseases, such as chronic otitis media and otosclerosis, which affect over 30 million people in the U.S...
  28. Genetics &Biology of M. catarrhalis LOS in Otitis Media
    Anthony A Campagnari; Fiscal Year: 2013
    ..It is the third leading cause of otitis media (OM) and there is a high colonization rate with M...
  29. CELLULAR AND MOLECULAR BIOLOGY OF CHOLESTEATOMA
    RICHARD ARTHUR CHOLE; Fiscal Year: 2013
    ..Aural cholesteatomas are epithelial cyst-like structures occurring in the middle ear as a complication of otitis media and when infected they are aggressive, recurrent and recalcitrant to treatment...
  30. Coordinate regulation of competence and pneumocin production in S. pneumoniae
    SUZANNE RACHEL DAWID; Fiscal Year: 2013
    ..pneumococcus) is an important human pathogen and the most common cause of bacterial meningitis, pneumonia and otitis media. Although it can cause significant disease, pneumococcus is part of the normal nasopharyngeal flora...
  31. Combinatorial Imaging of the Oral Microbiome
    Floyd E Dewhirst; Fiscal Year: 2010
    ..diseases such as dental caries, periodontal disease, alveolar osteitis, tonsillitis, strep throat and otitis media. The question of which organisms are present in the oral cavity has been extensively studied and over 600 ..
  32. BIOGENESIS AND INHIBITION OF BIOFILM-ASSOCIATED BACTERIAL AMYLOID
    Scott J Hultgren; Fiscal Year: 2013
    ..These include urinary tract infections (UTIs), chronic skin infections, otitis media and cystic fibrosis lung infections...
  33. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2013
    ..of palatoplasty with respect to improving Eustachian tube function (ETF) and reducing the prevalences of otitis media with effusion (OME) and hearing loss in cleft palate (CP) patients without causing adverse events or having ..
  34. Immune Responses in Otitis Prone Children
    Michael E Pichichero; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute Otitis Media (AOM) is the most common infectious disease among children...
  35. Mechanisms of pneumococcal persistence during carriage.
    JEFFREY NEAL WEISER; Fiscal Year: 2013
    ..This single species accounts for a large proportion of respiratory tract (pneumonia, otitis media) and invasive (sepsis, meningitis) bacterial diseases...
  36. Effect of the Middle Ear Inflammation On the Inner Ear
    STEVEN SUNG KYUN JUHN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM) is one of the most common of childhood diseases and a major public health problem. The disease can lead to middle ear and inner ear pathology and hearing loss...
  37. CYTOKINE INFLAMMATORY MEDIATORS AND MUCIN REGULATION IN MIDDLE EAR EPITHELIUM
    Joseph E Kerschner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM) is the most common diagnosis in pediatric patients who visit physicians for illness in the United States [1-2], affects more than 90% of all children by the age of 5 [3-4], is the ..
  38. Avian Middle Ear Development
    SUSAN CAROLINE CHAPMAN; Fiscal Year: 2012
    ..atresia, cholesteatoma, exostoses, otoschlerosis, glomus tumor, myringosclerosis of the tympanic membrane, otitis media and trauma...
  39. Innate and adaptive immune responses at the respiratory mucosa
    Yasmin Thanavala; Fiscal Year: 2010
    ..Interactions between these two pathogens have direct relevance to otitis media a disease of young children and also to a disease of adults, chronic obstructive pulmonary disease (COPD) the ..
  40. The effect of a protein-lipid complex from human milk against pneumococcal otitis
    Emily Clementi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute otitis media (AOM) is the most common childhood infection in the United States, affecting over 60% of infants during their first year of life, causing significant pain and transient hearing loss...
  41. Regulation of Inflammation by EGFR in Otitis Media
    Xiangbin Xu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children...
  42. Biomechanical Measurement and Modeling of Normal and Diseased Middle Ears
    Rong Z Gan; Fiscal Year: 2013
    ..The mechanical properties of soft tissues change in middle ear diseases such as otitis media. As a consequence, the mobility of ossicular chain is reduced and significant conductive hearing loss occurs in ..
  43. Molecular Mechanisms of Myelokathexis
    Andrew Aprikyan; Fiscal Year: 2009
    ..The patients experience recurrent infections including otitis media and otitis externa, HPV, gingivitis, and severe cutaneous and sinopulmonary infections...
  44. Advanced Research Training in Otolaryngology
    Marci M Lesperance; Fiscal Year: 2013
    ..mechanisms of auditory processing, tissue bioengineering, the molecular biology of neural regeneration, and otitis media. The research programs and facilities of the Department of Otolaryngology-Head and Neck Surgery and the Kresge ..
  45. Pathogenesis of Virus-Induced Acute Otitis Media
    Tasnee Chonmaitree; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media is one of the most common diseases seen in pediatric practice and the most common reason for antibiotic prescriptions in the U.S...
  46. A Pediatric Quality Measurement Center and Testing Laboratory
    Jeffrey H Silber; Fiscal Year: 2013
    ..a core measure of pediatric healthcare quality-avoidance of inappropriate use of antimicrobial therapy for otitis media with effusion-by adapting it for electronic health records;(3) Develop and validate pediatric readmission ..
  47. Innate Immunity in Otitis Media Pathogenesis
    David J Lim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Following the common cold, otitis media (OM), or inflammation of the middle ear, is the most frequent illness resulting in visits to physicians and the most common cause of hearing impairment and ..
  48. Up-regulation of Mucin Gene Transcription-Otitis Media
    Jian dong Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM) is the most common childhood bacterial infection and the leading cause of conductive hearing loss in children. Mucus overproduction is a hallmark of OM. S...
  49. Mechanisms of Persistence and Recovery in Otitis Media
    Stephen I Wasserman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM) is a major health problem, resulting in substantial health care expenditures. More than 90% of children experience OM...
  50. cdiGMP regulation of Biofilm Formation
    GEORGE A O'TOOLE; Fiscal Year: 2013
    ..well-documented studies of plaque, there is emerging evidence that biofilms on host tissues in Cystic Fibrosis, otitis media (e.g., ear ache) and endocarditis...
  51. Proteomic networks of MUC5B infectious/inflammatory induction in Otitis Media
    Diego Preciado; Fiscal Year: 2013
    ..b>Otitis media (OM), the most prevalent chronic childhood disorder, is associated with staggering public health care costs...
  52. Algorithms and Image Analysis Software Tool for Automated Recognition and Identif
    JELENA KOVACEVIC; Fiscal Year: 2010
    ..determination of developmental stages in Drosophila embryos, recognizing tissues in histology and diagnosis of otitis media. Thus: We propose to develop a flexible, modular and accurate algorithm and a software toolbox to automatically ..
  53. Metabolic regulation in otitis media
    DAYLE ANITA DAINES; Fiscal Year: 2012
    ..NTHi) are human-adapted commensal organisms that can also cause chronic mucosal infections, particularly otitis media. Since NTHi are not susceptible to the routinely-administered Hib vaccine, these infections are usually treated ..
  54. Sinusitis in Children and the Nasopharyngeal Microbiome
    Ellen Wald; Fiscal Year: 2013
    ..secondary bacterial infections of the respiratory tract in which there is an antecedent viral infection (acute otitis media, acute bacterial pneumonia and acute bacterial sinusitis)...
  55. Emerging Trends in Antibiotic Use and Their Impact on Primary Care for Children
    Jonathan A Finkelstein; Fiscal Year: 2013
    ..This has been associated with changes in diagnosis of otitis media, and other changes in health care utilization...
  56. Development of a vaccine for prevention of Haemophilus influenzae otitis media
    Stephen J Barenkamp; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media and other illnesses caused by nontypeable Haemophilus influenzae (NTHi) remain significant health problems for children and a vaccine for prevention of disease is much needed...
  57. Combinational regulation of inflammation in otitis media
    Jian dong Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Inflammation is a hallmark of OM...
  58. Brain Structure, Function, and Growth in Children with Oral Cleft
    Peggy C Nopoulos; Fiscal Year: 2012
    ..been considered as `secondary'to factors such as hearing deficits during development from chronic otitis media (which is ubiquitous in children with clefts) or even the psychological factors of living with a cleft...
  59. Middle Ear Response in Otitis Media
    Allen F Ryan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Otitis media is one of the largest public health problems of young children. Otitis media is thought to be a multifactorial condition that can be induced by a variety of inciting events...
  60. Inhibition of Biofilms on Tympanostomy Tubes
    Ted W Reid; Fiscal Year: 2010
    ..tympanostomy tubes with organo-selenium and test the resulting product in vitro against isolates obtained from otitis media patients. 2...
  61. Dx Ear: An automated tool for diagnosis of otitis media
    JELENA KOVACEVIC; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Otitis media is a general term for middle-ear inflammation that is classified clinically as either acute otitis media (AOM) or otitis media with effusion (OME)...
  62. 10th International Post-Symposium Research Conference on Recent Advances in Otiti
    LAUREN O contact BAKALETZ; Fiscal Year: 2011
    ..provided by applicant): The 2011 10th International Post-Symposium Research Conference in Recent Advances in Otitis Media, to be held on June 9 &10, in New Orleans, LA, will be the tenth of a series of quadrennial conferences ..
  63. THE EFFECTIVENESS OF VACCINES IN CLINICAL PRACTICE
    EUGENE DAVID SHAPIRO; Fiscal Year: 2010
    ..In addition, he will work on a randomized clinical trial of a "wait-and-see" approach to treating otitis media as a strategy to decrease unnecessary use of antibiotics. Dr...
  64. OTITIS MEDIA RESEARCH CENTER
    Charles Bluestone; Fiscal Year: 1990
    b>Otitis media (OM) is the most common illness for which children receive medical care in this country. Approximately $2 billion are spent annually on medical and surgical treatment...
  65. DEVELOPMENT OF A FIMBRIN VACCINE AGAINST OTITIS MEDIA
    LAUREN BAKALETZ; Fiscal Year: 1999
    b>Otitis media, or middle ear infection, is the second most prevalent childhood disease with hearing loss its most common complication...
  66. CYLD as a negative regulator for MUC5AC in NTHi-induced otitis media
    Erika Szymanski; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Otitis media is responsible for substantial human suffering, the most common reason for pediatric physician visits and antibiotic prescriptions to children, and the cause of over $5 ..
  67. Study of S pneumoniae Virulence Gene Regulation
    Andrew Camilli; Fiscal Year: 2002
    ..the pathogenicity of Streptococcus pneumoniae, the most common cause of bacteremia, bacterial meningitis, otitis media and community-acquired pneumonia in the U.S.A...
  68. STREPTOCOCCUS PNEUMONIAE ADHERENCE AND OTITIS MEDIA PATH
    Thomas Demaria; Fiscal Year: 2004
    DESCRIPTION: (Adapted from the Investigator's Abstract) Otitis media (middle ear inflammation) ranks first among the most common diagnoses requiring a physician's office visit and recent estimates indicate that virtually all children (99%..
  69. PREVENTION OF OTITIS MEDIA IN INFANTS AND CHILDREN
    Gerald Healy; Fiscal Year: 1990
    ..The program is organized into four projects: I. Otitis Media in the First Year of Life: epidemiology; chemoprophylaxis for preventions of recurrent and severe otitis media; ..
  70. Genomic Sequence of an Otitis Media Isolate of NTHi
    Robert Munson; Fiscal Year: 2003
    At the current time, we have a poor understanding of how nontypeable Haemophilus influenzae (NTHi) cause otitis media (OM) in children...
  71. Decision Analysis of Otitis Media Vaccination Strategies
    Tracy Lieu; Fiscal Year: 2005
    Background: Various candidate vaccines against otitis media are currently in development...
  72. RSV Upper Airway Infection and Otitis Media
    JOAN E contact DURBIN; Fiscal Year: 2010
    ..health problem as RSV has been shown to be the predominant viral pathogen predisposing children to bacterial otitis media (OM)...
  73. Ultrasound Characterization of Otitis Media
    Arne Voie; Fiscal Year: 2004
    ..that can identify different types of fluid that may accumulate in the middle ear space in the course of otitis media (middle ear infection)...
  74. Otitis Media Impact on the Inner Ear
    Dennis Trune; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): In spite of decades of study, it is still not clear how otitis media impacts the inner ear to cause sensorineural hearing loss...
  75. Xylitol syrup for the prevention of acute otitis media in otitis-prone children
    Louis Vernacchio; Fiscal Year: 2010
    ..In response to Challenge Area 04: Clinical Research and specific Challenge Topic 04-DC-101: Prevention of Otitis Media, we propose a clinical trial of a preparation of viscous xylitol with a mucosal adherence agent for the ..