labyrinth diseases

Summary

Top Publications

  1. ncbi Clinical manifestations of superior semicircular canal dehiscence
    Lloyd B Minor
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Johns Hopkins Outpatient Center, Baltimore, MD 21287, USA
    Laryngoscope 115:1717-27. 2005
  2. ncbi Disposition of nanoparticle-based delivery system via inner ear administration
    Gang Chen
    Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China
    Curr Drug Metab 11:886-97. 2010
  3. ncbi Auditory and vestibular hair cell stereocilia: relationship between functionality and inner ear disease
    R R Ciuman
    Department of Otorhinolaryngology, Head and Neck Surgery, Marienhospital Gelsenkirchen, Germany
    J Laryngol Otol 125:991-1003. 2011
  4. ncbi Communication routes between intracranial spaces and inner ear: function, pathophysiologic importance and relations with inner ear diseases
    Raphael R Ciuman
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Tubingen, Germany
    Am J Otolaryngol 30:193-202. 2009
  5. ncbi High-resolution CT findings suggest a developmental abnormality underlying superior canal dehiscence syndrome
    Timo P Hirvonen
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Acta Otolaryngol 123:477-81. 2003
  6. ncbi Management of labyrinthine fistulae in chronic ear surgery
    Benjamin J Copeland
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina, Chapel Hill, NC 27599 7070, USA
    Am J Otolaryngol 24:51-60. 2003
  7. ncbi [Posterior semicircular canal occlusion with microwave assisted technique in guinea pigs]
    J Liu
    Department of Otolaryngology, First Affiliated Hospital, Jinzhou Medical College, Jinzhou 121001
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 15:28-30. 2001
  8. ncbi Value of lying-down nystagmus in the lateralization of horizontal semicircular canal benign paroxysmal positional vertigo
    Ja Won Koo
    Department of Otolaryngology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    Otol Neurotol 27:367-71. 2006
  9. ncbi Dizziness, hyperactive caloric responses, otic capsule demineralization, impaired glucose tolerance, and hyperinsulinemia
    Kenneth H Brookler
    Neurotologic Associates, New York City, USA
    Ear Nose Throat J 85:224, 229. 2006
  10. ncbi Labyrinthine fistulae: pathobiology and management
    Lloyd B Minor
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Curr Opin Otolaryngol Head Neck Surg 11:340-6. 2003

Research Grants

Detail Information

Publications190 found, 100 shown here

  1. ncbi Clinical manifestations of superior semicircular canal dehiscence
    Lloyd B Minor
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Johns Hopkins Outpatient Center, Baltimore, MD 21287, USA
    Laryngoscope 115:1717-27. 2005
    ..To investigate hypotheses about the effects of superior canal dehiscence. To analyze the outcomes in patients who underwent surgical repair of the dehiscence...
  2. ncbi Disposition of nanoparticle-based delivery system via inner ear administration
    Gang Chen
    Department of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China
    Curr Drug Metab 11:886-97. 2010
    ..The routes and applications for local inner-ear drug delivery will also be mentioned. In closing, this review will give an overview of the potential future development in inner ear administration with nanoparticles...
  3. ncbi Auditory and vestibular hair cell stereocilia: relationship between functionality and inner ear disease
    R R Ciuman
    Department of Otorhinolaryngology, Head and Neck Surgery, Marienhospital Gelsenkirchen, Germany
    J Laryngol Otol 125:991-1003. 2011
    ..g. Ménière's disease). The anatomical and physiological characteristics of stereocilia are discussed in relation to inner ear malfunctions...
  4. ncbi Communication routes between intracranial spaces and inner ear: function, pathophysiologic importance and relations with inner ear diseases
    Raphael R Ciuman
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Tubingen, Germany
    Am J Otolaryngol 30:193-202. 2009
    ..They possess a key role in inner ear pressure regulation and fluid homeostasis and are related to inner ear diseases...
  5. ncbi High-resolution CT findings suggest a developmental abnormality underlying superior canal dehiscence syndrome
    Timo P Hirvonen
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Acta Otolaryngol 123:477-81. 2003
    ..Findings on temporal bone CT were analyzed to determine if a developmental abnormality is associated with the syndrome...
  6. ncbi Management of labyrinthine fistulae in chronic ear surgery
    Benjamin J Copeland
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina, Chapel Hill, NC 27599 7070, USA
    Am J Otolaryngol 24:51-60. 2003
    ..Results of this critical review were presented at departmental grand rounds. The grand rounds presentation, data and discussion are presented to better illuminate the topic of labyrinthine fistula management...
  7. ncbi [Posterior semicircular canal occlusion with microwave assisted technique in guinea pigs]
    J Liu
    Department of Otolaryngology, First Affiliated Hospital, Jinzhou Medical College, Jinzhou 121001
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 15:28-30. 2001
    ..CONCLUSION: Posterior semicircular occlusion with microwave technique is suggested as an effective and safe treatment for the benign paroxysmal positional vertigo...
  8. ncbi Value of lying-down nystagmus in the lateralization of horizontal semicircular canal benign paroxysmal positional vertigo
    Ja Won Koo
    Department of Otolaryngology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    Otol Neurotol 27:367-71. 2006
    ..We studied the values of nystagmus induced by position change from sitting to supine in the lateralization of horizontal canal benign paroxysmal positional vertigo...
  9. ncbi Dizziness, hyperactive caloric responses, otic capsule demineralization, impaired glucose tolerance, and hyperinsulinemia
    Kenneth H Brookler
    Neurotologic Associates, New York City, USA
    Ear Nose Throat J 85:224, 229. 2006
  10. ncbi Labyrinthine fistulae: pathobiology and management
    Lloyd B Minor
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Curr Opin Otolaryngol Head Neck Surg 11:340-6. 2003
    ....
  11. ncbi Acoustic responses of vestibular afferents in a model of superior canal dehiscence
    John P Carey
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Otol Neurotol 25:345-52. 2004
    ..Afferents innervating the superior semicircular canal are rendered especially sensitive to acoustic stimulation when there is a dehiscence of the superior canal. Other vestibular end organs are also more sensitive to acoustic stimulation...
  12. ncbi Benign paroxysmal positional vertigo as a complication of interventions with osteotome and mallet
    Miguel Penarrocha
    J Oral Maxillofac Surg 64:1324; author reply 1324. 2006
  13. ncbi Can low frequency sound stimulation during posturography help diagnosing possible perilymphatic fistula in patients with sensorineural hearing loss and/or vertigo?
    Z Selmani
    Department of Otolaryngology, Central Hospital of Satakunta, 28500, Pori, Finland
    Eur Arch Otorhinolaryngol 261:129-32. 2004
    ..In eight cases, Hennebert's sign was present with nystagmus, without PLF. We conclude that pathological responses to the LFS test in posturography can also be encountered in other inner ear diseases without PLF...
  14. ncbi Superior semicircular canal dehiscence syndrome and multi-detector row CT
    Hugh D Curtin
    Radiology 226:312-4. 2003
  15. ncbi Outcome of hearing and vertigo after surgery for congenital perilymphatic fistula in children
    Peter C Weber
    Departments of Otolaryngology and Communicative Disorders, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Otolaryngol 24:138-42. 2003
    ..To determine if surgery to repair a perilymphatic fistula (PLF) has any significant morbidity and to determine the outcome of the surgery in regards to hearing and vertiginous symptoms...
  16. ncbi Cavernous angiomas within the internal auditory canal
    Madjid Samii
    International Neuroscience Institute and Department of Neurosurgery, Nordstadt Hospital, Klinikum Hannover, Germany
    J Neurosurg 105:581-7. 2006
    ..The aim of this study was to describe the symptomatology, radiological features, and surgical treatment of patients with cavernous angiomas within the internal auditory canal (IAC)...
  17. ncbi Horizontal canal type BPPV: bilaterally affected case treated with canal plugging and Lempert's maneuver
    Arata Horii
    Department of Otolaryngology, Osaka University Medical School, Osaka, Japan
    ORL J Otorhinolaryngol Relat Spec 65:366-9. 2003
    ..Canal plugging combined with Lempert's maneuver to the other side is one treatment option for intractable bilateral horizontal canal BPPV...
  18. ncbi Superior semicircular canal dehiscence syndrome: Leaks and squeaks can make you dizzy
    Robert W Baloh
    Neurology 62:684-5. 2004
  19. ncbi Occult otologic fistulas as a cause of recurrent meningitis
    B E Mostafa
    Ain Shams University, Faculty of Medicine, Cairo, Egypt
    Rev Laryngol Otol Rhinol (Bord) 126:25-8. 2005
    ..Occult perilymph fistulas may be the cause of unexplained non-epidemic meningitis...
  20. ncbi [Validation of a clinical scale for the diagnosis of perilymphatic fistula]
    D Portmann
    Institut Georges Portmann, 114 Avenue d Ares, F 33074 Bordeaux cedex, France
    Rev Laryngol Otol Rhinol (Bord) 126:243-8. 2005
    ..The goal of this article is to study the clinical situations where you must suspect a PLF and to support a clinical scale described in a previous work (Bussières et al 2003)...
  21. ncbi [Benign paroxysmal positional vertigo of the anterior semicircular canal: clinical aspects and treatment]
    P Lorin
    Rev Laryngol Otol Rhinol (Bord) 126:263-6. 2005
    ..To describe the videonystagmographic characteristics and the treatment of the patients reached with a canalolithiasis or a cupulolithiasis of the anterior semicircular canal...
  22. ncbi [Horizontal canal benign paroxysmal positional vertigo--its affected side and horizontal semicircular canal function]
    Nobuya Fujita
    Department of Otolaryngology, Nara Medical University, Nara University
    Nihon Jibiinkoka Gakkai Kaiho 108:202-6. 2005
    ..The mechanism causing a difference in caloric test results between canalolithiasis and cupulolithiasis patients thus requires a larger patient population and further examination to be conclusive...
  23. ncbi Superior canal dehiscence is not due to cephalic displacement of the labyrinth
    Valeria L Potyagaylo
    The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann N Y Acad Sci 1039:498-502. 2005
    ..Results showed that neither was the case. Instead, the defect may be in the process of ossification above the superior canal...
  24. ncbi Internal auditory canal hyperostosis in myotonic dystrophy
    Luis Lassaletta
    Department of Otolaryngology, La Paz University Hospital, Madrid, Spain
    Otol Neurotol 26:310-1. 2005
  25. ncbi Benign paroxysmal positional vertigo due to a simultaneous involvement of both horizontal and posterior semicircular canals
    Takao Imai
    Department of Otolaryngology, Kansai Rosai Hospital, Hyogo, and Department of Otolaryngology, Osaka Universityu Medical School, Japan
    Audiol Neurootol 11:198-205. 2006
    ..The observation of a vertical-torsional positional nystagmus should prompt the specialist to perform not only the canalith repositioning procedure, but also to execute lateral head turns in the supine position...
  26. ncbi Operative management of a posterior semicircular canal dehiscence
    Anthony A Mikulec
    Department of Otology and Laryngology, Harvard Medical School Massachusetts Eye and Ear InfirmaryBoston, Massachusetts 02114, USA
    Laryngoscope 116:375-8. 2006
    ..The objective of this study was to describe the operative management of posterior canal dehiscence...
  27. ncbi Mondini-like malformation mimicking otosclerosis and superior semicircular canal dehiscence
    M Karlberg
    Department of Otorhinolaryngology Head and Neck Surgery, Lund University Hospital, Sweden
    J Laryngol Otol 120:419-22. 2006
    ..Mondini-like cochlear dysplasia should be added to the causes of inner-ear conductive hearing loss...
  28. ncbi [Analysis of auditory steady-state response to multiple simultaneous stimuli and cochlea morphology in guinea pigs with posterior semicircular canal fistula]
    Nan ping Xie
    Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:495-7. 2006
    ..To observe the changes of auditory steady-state response (ASSR) threshold in guinea pigs with posterior semicircular canal fistula...
  29. ncbi "Spontaneous" perilymph fistula: a case report
    Patrick J Collison
    Yankton Medical Clinic, University of South Dakota School of Medicine, Yankton, South Dakota, USA
    Ann Otol Rhinol Laryngol 113:329-34. 2004
    ..The presence of intact evoked otoacoustic emissions in an ear demonstrating a severe cochlear-type loss was considered helpful in narrowing the differential diagnosis in this case, and may suggest a productive avenue for future study...
  30. ncbi Hearing loss with semicircular canal fistula in exotoxin A-deficient Pseudomonas otitis media
    Tariq M Yunus
    Department of Otolaryngology, University of Florida, Gainseville, FL 32610 0264, USA
    Otolaryngol Head Neck Surg 130:430-6. 2004
    ....
  31. ncbi Cranial thickness in superior canal dehiscence syndrome: implications for canal resurfacing surgery
    David R Friedland
    Division of Otology and Neuro otologic Skull Base Surgery, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Otol Neurotol 27:346-54. 2006
    ..To use morphometric analyses of cranial thickness to investigate 2 cases of unanticipated calvarial bone resorption in superior canal dehiscence (SCD) resurfacing surgery...
  32. ncbi Semicircular canal dehiscence: comparison of T2-weighted turbo spin-echo MRI and CT
    G A Krombach
    Department of Diagnostic Radiology, University of Technology, Pauwelstrasse 30, 52057 Aachen, Germany
    Neuroradiology 46:326-31. 2004
    ..MRI imaging thus had a sensitivity of 96% and specificity of 98%. Knowledge of the appearances of this entity on MRI may contribute to early diagnosis in patients with vertigo due to semicircular canal dehiscence...
  33. ncbi Unexpected complication of posterior canal occlusion surgery for benign paroxysmal positional vertigo
    Syed S Rizvi
    Department of Otolaryngology and Head and Neck Surgery, Bay Medical Center, Bay City, Michigan, USA
    Otol Neurotol 23:938-40. 2002
    ....
  34. ncbi Lateral semicircular canal dehiscence
    Marc K Bassim
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7070, USA
    Otol Neurotol 28:1155-6. 2007
  35. ncbi Clinical and diagnostic characterization of canal dehiscence syndrome: a great otologic mimicker
    Guangwei Zhou
    Department of Otolaryngology and Communication Disorders, Children s Hospital Boston, MA 02115, USA
    Otol Neurotol 28:920-6. 2007
    ..To identify otologic and audiologic characteristics of superior (and posterior) semicircular canal dehiscence (SCD)...
  36. ncbi Vestibular-evoked myogenic potentials in the diagnosis of superior canal dehiscence syndrome
    S O Streubel
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Acta Otolaryngol Suppl 545:41-9. 2001
    ..Rather than being based upon a single test, the diagnosis of SCD syndrome is best established when the characteristic symptoms, signs, VEMP response, and CT imaging all indicate SCD...
  37. ncbi Labyrinthine fistula detection: the predictive value of vestibular symptoms and computerized tomography
    E Kvestad
    Department of Otorhinolaryngology, , Oslo, Norway
    Acta Otolaryngol 121:622-6. 2001
    ..In conclusion, the identification of a younger group of patients presenting with fewer symptoms indicates that fistulas should be suspected in all patients undergoing surgery for chronic middle ear and mastoid disease...
  38. ncbi Treatment outcomes of benign paroxysmal positional vertigo
    D Sherman
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia
    J Otolaryngol 30:295-9. 2001
    ..The sham treatment causes a delay in spontaneous recovery, possibly by preventing the particles from falling into the utricle. This study has not compared the frequency or severity of symptoms...
  39. ncbi Labyrinthine fistulae: a retrospective analysis
    C Vanclooster
    Department Otorhinolaryngology, Head and Neck Surgery, KUL, Leuven, Belgium
    Acta Otorhinolaryngol Belg 51:119-21. 1997
    ..Eighteen percent of the ears were pre-operatively totally deaf. Large fistulae are riskier than smaller ones for post-operative perceptive losses, but even in very large and multiple fistulae the hearing may be preserved in most cases...
  40. ncbi Transmastoid superior semicircular canal occlusion
    Sumit K Agrawal
    Department of Otolaryngology, University of Western Ontario, London, Canada
    Otol Neurotol 29:363-7. 2008
    ..The traditional surgical repair for superior semicircular canal dehiscence (SSCD) involves either canal plugging or resurfacing via the middle cranial fossa approach. We describe a novel transmastoid occlusion technique...
  41. ncbi Pediatric fluctuating sensorineural hearing loss: problems in medical management
    E A Dinces
    Department of Otolaryngology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Laryngoscope 111:21-5. 2001
    ..In the other patients with positive LTTs, parents or other physicians were often reluctant to treat, or the patient was lost to follow-up. Mean fluctuations varied substantially across all standard audiometric frequencies for all groups...
  42. ncbi Three-dimensional imaging of the inner ear by volume-rendered reconstructions of magnetic resonance data
    Randolf Klingebiel
    Neuroradiology Section, Department of Radiology, Charité CM, Schumannstr 20 21, 10098 Berlin, Germany
    Arch Otolaryngol Head Neck Surg 128:549-53. 2002
    ..To evaluate 3-dimensional inner ear visualization by volume rendering of high-resolution magnetic resonance data in patients with clinically suspected inner ear abnormality...
  43. pmc Fluid-particle dynamics in canalithiasis
    Dominik Obrist
    Institute of Fluid Dynamics, ETH Zurich, 8092 Zurich, Switzerland
    J R Soc Interface 5:1215-29. 2008
    ..We propose a set of dimensionless numbers to characterize canalithiasis and derive explicit expressions connecting these dimensionless numbers directly to the typical clinical symptoms...
  44. ncbi [Diagnosis and management of benign paroxysmal positional vertigo]
    F Schmal
    Hals Nasen Ohrenklinik des Universitätsklinikums Münster
    Laryngorhinootologie 81:368-80. 2002
    ..Although the BPPV usually is a self-limited disorder treatment with a specific bedside maneuver is effective and can shorten the duration of symptoms...
  45. ncbi Intraoperative assessment of perilymphatic fistulas with intrathecal administration of fluorescein
    Eckard Gehrking
    Department of Otorhinolaryngology, Medical University of Lubeck, Germany
    Laryngoscope 112:1614-8. 2002
    ..To improve objectivity in the intraoperative visualization of perilymphatic fistulas, we used intrathecal fluorescein for perilymph staining to increase the sensitivity and specificity of diagnosis of perilymphatic fistulas...
  46. ncbi An indicator of probable semicircular canal dehiscence: ocular vestibular evoked myogenic potentials to high frequencies
    Leonardo Manzari
    MSA ENT Academy Center, Cassino, Italy
    Otolaryngol Head Neck Surg 149:142-5. 2013
    ..In 22 healthy subjects, oVEMP n10 at 4000 Hz was not detectable; however, in all 22 CT-verified SSCD patients tested, oVEMP n10 responses were clearly present to 4000 Hz to either ACS or BCV stimuli. ..
  47. ncbi Lipoma of the internal auditory canal and cerebellopontine angle
    Gian Gaetano Ferri
    Department of Surgical and Anesthesiological Sciences, Ear Nose and Throat Clinic, S Orsola Malpighi University Hospital, Bologna, Italy
    Otol Neurotol 25:1027-8. 2004
  48. pmc Current status and prospects of gene therapy for the inner ear
    Hong Sun
    Department of Otolaryngology, Head and Neck Surgery, Xiang Ya Hospital, Central South University, Changsha, Hunan 410008, China
    Hum Gene Ther 22:1311-22. 2011
    ..We also discuss the progress and prospects of inner ear gene therapy, the advances and shortcomings, with possible solutions in this field of research...
  49. ncbi Effects of Chlorpheniramine and L-histidine on vestibular compensation in goldfish, Carassius auratus
    Aline Cristina Piratello
    Laboratory of Neuroscience, Universidade Federal de Sao Carlos, Via Washington Luis, km 235, 13 565 905, Sao Carlos, SP, Brazil
    Neurosci Lett 367:160-3. 2004
    ..Chlorpheniramine accelerated the functional recovery when compared with that of the saline group. These data suggest that the inhibition of the histaminergic system facilitates the functional recovery in goldfish...
  50. ncbi Tumors of the endolymphatic sac in von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 350:2481-6. 2004
  51. ncbi Surgical management of the labyrinthine fistula complicating chronic otitis media with or without cholesteatoma
    Giuseppe Magliulo
    Department of Otorhinolaryngology, Audiology and Phoniatrics, University La Sapienza of Rome, Rome, Italy
    J Otolaryngol Head Neck Surg 37:143-7. 2008
    ..To present our most recent experience on the diagnosis and treatment of the labyrinthine fistula. The relative data are compared with those of our past experiences adopting the same modality of presenting the results...
  52. ncbi Pneumolabyrinth associated with perilymph fistula
    Shih Hung Lo
    Department of Otolaryngology, Cathay General Hospital, 280, Jen Ai Rd, Taipei, Taiwan, ROC
    Chang Gung Med J 26:690-4. 2003
    ..Right side exploratory tympanotomy confirmed the presence of a perilymph fistula. The patient was free of symptoms after surgery. Early fistula repair was beneficial in this case...
  53. ncbi [Intratympanic drug delivery for the treatment of inner ear diseases]
    Carlos Herraiz
    Servicio de Otorrinolaringologia, Hospital Universitario Fundacion Alcorcon, Madrid, Espana
    Acta Otorrinolaringol Esp 61:225-32. 2010
    Intratympanic drug delivery for labyrinth diseases is a non-aggressive outpatient procedure where drugs reach high concentrations in the cochlea and minimum systemic diffusion...
  54. ncbi A causative link between inner ear defects and long-term striatal dysfunction
    Michelle W Antoine
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 341:1120-3. 2013
    ....
  55. ncbi Benign paroxysmal positional vertigo secondary to inner ear disease
    No Hee Lee
    Department of Otorhinolaryngology Head and Neck Surgery, Hongik Medical Center, Seoul, Korea
    Otolaryngol Head Neck Surg 143:413-7. 2010
    ..To contrast clinical characteristics of secondary benign paroxysmal positional vertigo (s-BPPV) with idiopathic BPPV (i-BPPV)...
  56. ncbi Transient evoked otoacoustic emissions in superior canal dehiscence syndrome
    Elsaeid M Thabet
    Audiology Unit, ORL Department, Faculty of Medicine, Mansoura University, 60 El Gomhuria st, Mansoura, Egypt
    Eur Arch Otorhinolaryngol 268:137-41. 2011
    ....
  57. ncbi [Perilymphatic fistula. Diagnostic and therapeutic difficulties]
    F Legent
    Clinique ORL, Hotel Dieu, Nantes
    Ann Otolaryngol Chir Cervicofac 105:465-75. 1988
    ..Simple filling of the breach is not always effective, especially at the level of the stapes. Stapedectomy frequently constitutes the best solution for fistulae of the fenestra ovalis...
  58. ncbi The Tullio phenomenon and perilymph fistula
    E J Fox
    Colorado Ear Clinic, Denver 80210
    Otolaryngol Head Neck Surg 98:88-9. 1988
    ..Six of these were found to have active, free-flowing fistulas at the time of exploration. The presence of a Tullio phenomenon may be helpful in preoperative assessment of a patient with suspected perilymph fistula...
  59. ncbi Cell therapy for inner ear diseases
    T Nakagawa
    Department of Otolaryngology Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Curr Pharm Des 11:1203-7. 2005
    ..These cell transplantation findings provide a sound foundation for the development of therapies to treat inner ear disorders...
  60. ncbi Compensation mechanisms after acute peripheral disorders of the labyrinth as a function of age
    U Barion
    Department of Otolaryngology, University of Padua
    Acta Otorhinolaryngol Belg 42:28-34. 1988
    ..The study's results are reported, and several problems connected to the interference of the aging process on the mechanism of vestibular compensation are examined...
  61. ncbi Perilymph fistula resulting from microfissures
    D B Kamerer
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Eye and Ear Hospital, PA 15213
    Am J Otol 8:489-94. 1987
    ..Speculation as to the type of hearing loss caused by fistulas will be offered. Hypotheses concerning the various symptoms encountered in patients and the location of the defect will also be addressed...
  62. pmc Radiographic features of superior semicircular canal dehiscence in the setting of chronic ear disease
    Brian C Gartrell
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, Department of Radiology, Section of Neuroradiology, Department of Surgery, Division of Otolaryngology Head and Neck Surgery, Section of Otology and Neurotology, University of Wisconsin Hospital and Clinics and Waisman Center, University of Wisconsin Madison, Madison, Wisconsin, U S A
    Otol Neurotol 35:91-6. 2014
    ..To determine if radiologic chronic otitis media (COM), both with and without cholesteatoma, is associated with superior semicircular canal dehiscence (SSCD)...
  63. ncbi Serial audiometry in a clinical trial of AIED treatment
    John K Niparko
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University, Baltimore, MD, USA
    Otol Neurotol 26:908-17. 2005
    ..We sought to characterize the pattern and size of the treatment effect as reflected in clinical audiometry and to identify audiometric predictors of response to steroid treatment of AIED...
  64. ncbi High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats
    Wei Jia Kong
    Department of Otolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Acta Otolaryngol 131:692-700. 2011
    ..This study also indicated that inner ear-specific antigens can be involved in autoimmune reactions. Cell-mediated immune injury can play an important role in the induction of AIED, at least in the earlier stage...
  65. ncbi A regulated delivery system for inner ear drug application
    Shayanne A Lajud
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    J Control Release 166:268-76. 2013
    ..To evaluate this effect, we tested gentamicin (GENT) in the inner ear following CGP delivery with/without regulation...
  66. ncbi Imaging for cochlear implantation: structuring a clinically relevant report
    S Vaid
    Head Neck and ENT Imaging Division, Star Imaging and Research Center, Pune, India Electronic address
    Clin Radiol 69:e9-e24. 2014
    ..A constant communication between the imaging specialist and the cochlear implant surgeon improves image interpretation and ensures a successful implantation. ..
  67. ncbi Cogan's syndrome: an autoimmune inner ear disease
    A Greco
    ENT Department, Policlinico Umberto I, University of Rome Sapienza, Italy
    Autoimmun Rev 12:396-400. 2013
    ..The objective of our study was to review our current knowledge of the aetiopathogenesis of Cogan's syndrome, including viral infection and autoimmunity, and to discuss disease pathogenesis with relevance to pharmacotherapy...
  68. ncbi Endoscopy of the inner ear
    Michael H Fritsch
    Department of Otolaryngology Head and Neck Surgery, Indiana University Medical Center, 702 Barnhill Drive, Suite 0860, Indianapolis, IN 46202, USA
    Otolaryngol Clin North Am 42:1209-22, Table of Contents. 2009
    ..Endoscopic inner ear surgery is a challenging, but potentially very useful method to address inner ear problems...
  69. ncbi Intratympanic steroids for inner ear disorders: a review
    Amanda Hu
    Department of Otolaryngology, University of Western Ontario, London, Ontario, Canada
    Audiol Neurootol 14:373-82. 2009
    ..The aim of this study was to review the clinical trials of ITS for inner ear disorders...
  70. ncbi Intralabyrinthine schwannomas: imaging diagnosis and classification
    K L Salzman
    Department of Radiology, University of Utah, Salt Lake City, 84132 2140, USA
    AJNR Am J Neuroradiol 33:104-9. 2012
    ..Treatment and prognosis hinge on the appropriate localization of these tumors; thus, a concise terminology that can be used by both the otolaryngologist and radiology communities is desirable...
  71. pmc Immunosuppressive therapy for autoimmune inner ear disease
    Maria C Buniel
    Cleveland Clinic, Lerner Research Institute, Department of Immunology, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Immunotherapy 1:425-34. 2009
    ..Here we discuss the basic science and clinical research surrounding the history of immunosuppressive therapy in AIED...
  72. ncbi Endolymphatic sac tumours
    D A Luff
    Department of Otolaryngology, Head and Neck Surgery, Manchester Royal Infirmary, UK
    J Laryngol Otol 116:398-401. 2002
    ..The controversy regarding the cellular origins of adenomatous tumours of the temporal bone is highlighted...
  73. ncbi Anatomical feature of the middle cranial fossa in fetal periods: possible etiology of superior canal dehiscence syndrome
    Naoto Takahashi
    Department of Otolaryngology, Tokyo Medical and Dental University, Japan
    Acta Otolaryngol 132:385-90. 2012
    ..This might cause adhesion of the membranous labyrinth to dura as the bony labyrinth develops much later than the membranous labyrinth. This adhesion interferes with ossification and leads to a bony defect in the SSC...
  74. ncbi Reversible peripheral vestibulopathy: the treatment of superior canal dehiscence
    Todd A Hillman
    Pittsburgh Ear Associates, 420 E North Avenue, Suite 402, Pittsburgh, PA 15212, USA
    Otolaryngol Head Neck Surg 134:431-6. 2006
    ..We have reviewed 30 cases of SCD found at our institution and report their presentation, workup, and response to therapy...
  75. ncbi [3 cases of post-stapedectomy labyrinthine fistula]
    M Fusetti
    Cattedra di ORL,
    Acta Otorhinolaryngol Ital 17:436-43. 1997
    ....
  76. ncbi THE ABNORMALITIES OF THE INNER EAR IN KREISLER MICE
    M S Deol
    J Embryol Exp Morphol 12:475-90. 1964
  77. ncbi Do viruses cause inner ear disturbances?
    I Pyykko
    Department of Otolaryngology, University of Tampere, Tampere, Finland
    ORL J Otorhinolaryngol Relat Spec 70:32-40; discussion 40-1. 2008
    ..In conclusion, VZV, Coxsackie virus B5 and influenza B virus may be the main causes of inner ear disorder. The spiral and Scarpa's ganglion are potential sites harboring viral DNA for possible latent infection...
  78. ncbi [Traumatic perilymphatic fistulae : about 13 cases]
    Nadia Kaffel
    Hopital Charles Nicolle, Tunis, Tunisie
    Tunis Med 89:471-5. 2011
    ..The diagnosis can be suspected on the bases of the clinical and the audiometrial findings. Indications for exploratory surgery in cases of trauma are vague and not well described...
  79. ncbi Benign paroxysmal positional vertigo in older women may be related to osteoporosis and osteopenia
    Dominique Vibert
    Department of Otorhinolaryngology Head and Neck Surgery, Inselspital, University of Berne, Berne, Switzerland
    Ann Otol Rhinol Laryngol 112:885-9. 2003
    ..The patients with BPPV had a significantly lower (p < .026) T-score in all groups. Possible pathophysiological mechanisms are discussed to explain the apparent correlation between BPPV and osteopenia or osteoporosis...
  80. ncbi [Intralabyrinthine schwannoma extending into the round window niche and internal auditory canal]
    Yoshihiro Noguchi
    Department of Otolaryngology, Tokyo Medical and Dental University, Tokyo
    Nihon Jibiinkoka Gakkai Kaiho 115:687-92. 2012
    ..Pathological examination showed an Antoni A type schwannoma with fibrous changes of the semicircular canals. We should remember this inner..
  81. ncbi Preoperative high resolution CT and MR imaging in cochlear implantation
    A Abdullah
    Department of Otorhinolaryngology, Faculty of Allied Health Sciences, University Kebangsaan Malaysia
    Ann Acad Med Singapore 32:442-5. 2003
    ....
  82. ncbi Traces of perilymph detected in epipharyngeal fluid: perilymphatic fistula as a cause of sudden hearing loss diagnosed with beta-trace protein (prostaglandin D synthase) immunoelectrophoresis
    G Bachmann
    Department of Otorhinolaryngology and Neurology, University of Cologne, Cologne, Germany
    J Laryngol Otol 115:132-5. 2001
    ..Upon repeating tympanoscopy there was no obvious labyrinthine fluid egress, but the oval window was sealed with fibrin sponge and fibrin glue. The patient's hearing improved over a period of five months...
  83. ncbi [Episodic attacks of vertigo]
    F Schmal
    HNO 51:845-58; quiz 859. 2003
  84. ncbi [Recent progress in the diagnosis of otorhinolaryngological diseases--application of functional imaging of the brain]
    Yasushi Naito
    Nihon Jibiinkoka Gakkai Kaiho 109:75-83. 2006
  85. ncbi Vestibular rehabilitation's effect over the quality of life of geriatric patients with labyrinth disease
    Erika Barioni Mantello
    Internal Medicine Department, Ribeirao Preto Medical School, Sao Paulo University, SP Brazil
    Braz J Otorhinolaryngol 74:172-80. 2008
    ..Dizziness is a symptom that affects the population world over, being more prevalent in the elderly due to the process of functional deterioration of the hearing and vestibular systems with aging...
  86. ncbi Intratympanic administration of methylprednisolone reduces impact of experimental intensive impulse noise trauma on hearing
    Yide Zhou
    Department of Otolaryngology, Changhai Hospital, Shanghai, China
    Acta Otolaryngol 129:602-7. 2009
    ..The present findings demonstrated that intratympanic methylprednisolone (MP) reduces the impact of impulse noise trauma on hearing and in part preserves the hair cells from death 1 h after exposure to intensive impulse noise...
  87. ncbi Perilymphatic fistula in guinea pigs: natural evolution versus surgical treatment
    Ektor Tsuneo Onishi
    Federal University of Sao Paulo Escola Paulista de Medicina
    Braz J Otorhinolaryngol 76:178-84. 2010
    ..Perilymphatic fistulas still represent a major treatment challenge. In some cases, its surgical closure can reduce auditory and vestibular sequelae...
  88. ncbi Superior semicircular canal dehiscence presenting as postpartum vertigo
    Karen F Watters
    Eaton Peabody Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Otol Neurotol 27:756-68. 2006
    ..To describe the clinical and diagnostic features of superior semicircular canal dehiscence (SSCD) in patients with postpartum vertigo...
  89. ncbi Computed tomography-based workup of conductive hearing loss with normal middle ear: don't forget superior semicircular canal dehiscence
    Christian B Teszler
    Otology Neurootology Unit, Fondation Adolphe de Rothschild, Paris, France
    Int Tinnitus J 14:53-6. 2008
    ..The aim of this study is to remind radiologists and otolaryngologists that SSCD should be systematically considered among the etiologies of CHL with normal ME...
  90. ncbi Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate
    Hirokazu Suzuki
    Department of Otorhinolaryngology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 131:130-5. 2011
    ..There was no morphological change in the stria vascularis after Gd-DTPA or Gd-DTPA-BMA was placed on the round window of guinea pigs...
  91. ncbi Superior semicircular canal dehiscence simulating otosclerosis
    G Michael Halmagyi
    Neurology Department, Royal Prince Alfred Hospital, Sydney, and the Otolaryngology Department, St Vincent s Hospital, Sydney, Australia
    J Laryngol Otol 117:553-7. 2003
    ....
  92. ncbi [Vertigo induced by noise or pressure to the left ear]
    D U Seidel
    Klinik für HNO Heilkunde, Kopf und Halschirurgie, Plastische Operationen, Malteser Krankenhaus St Anna, Albertus Magnus Strasse 33, 47259, Duisburg, Deutschland
    HNO 59:596-9. 2011
    ..CT of the petrous bone showed a bony dehiscence of the left superior semicircular canal. Conservative therapy was initiated as a first step...
  93. ncbi Actinomycosis of the temporal bone with labyrinthine and facial nerve involvement
    Deepak Mehta
    Department of Pediatric Otolaryngology, Cincinnati Children s Hospital and Medical Center, Cincinnati, OH 45229, USA
    Laryngoscope 117:1999-2001. 2007
    ..To demonstrate the clinical, radiologic, and pathologic findings of actinomycosis of the temporal bone...
  94. ncbi [Mondini dysplasia: recurrent bacterial meningitis in adolescence]
    J Vargas-Dĭaz
    Instituto de Neurologia y Neurocirugia, Ciudad de La Habana, Cuba
    Rev Neurol 39:935-9. 2004
    ..Congenital deformity of the bony labyrinth can be linked to a fistulous tract communicating it with the intracranial subarachnoid space. Mondini deformity is a frequent malformation in congenitally deaf patients...
  95. ncbi Application of parasagittal surface coil MRI to otoneurological diagnosis
    Y Naito
    Department of Hearing and Speech Science, Graduate School of Medicine, Kyoto University, Japan
    Acta Otolaryngol Suppl 528:85-90. 1997
    ..The present method provides a new approach to the assessment of otoneurological disorders...
  96. ncbi Posterior petrous meningiomas: 82 cases
    Zhe Bao Wu
    Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical College, Wenzhou, People s Republic of China
    J Neurosurg 102:284-9. 2005
    ..The aim of this study was to discuss posterior petrous meningiomas--their classification, clinical manifestations, surgical treatments, and patient outcomes...
  97. ncbi [Cerebellopontine angle and internal auditory canal lipomas: report of four cases and review of the literature]
    N Rodriguez Prado
    Servicio ORL del Hospital Universitario Central de Asturias, Oviedo
    Acta Otorrinolaringol Esp 55:126-30. 2004
    ..We evaluate clinical, histological and radiological characteristics of the cases diagnosed in our Hospital and the results of conservative versus surgical treatment...
  98. ncbi Use of the loud sound stimulation test in diagnosis of semicircular canal dehiscence syndrome
    Ya Feng Yu
    Department of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China
    Eur Arch Otorhinolaryngol 268:513-8. 2011
    ..In addition, the loud sound stimulation test has unique advantages, especially for confirming the affected ear and the corresponding semicircular canal...
  99. ncbi Experimental study of speed-dependent positional nystagmus in benign paroxysmal positional vertigo
    Masayoshi Furuya
    Department of Otolaryngology, Tokyo Medical University, Tokyo, Japan
    Acta Otolaryngol 123:709-12. 2003
    ..The aim of this study was to examine factors determining the symptoms of BPPV using models of canalolithiasis and cupulolithiasis...
  100. ncbi [The evaluation of the efficiency of kinesitherapy in the patients with mixed-type vertigo]
    Marzena Bielińska
    Klinika Otolaryngologii i Onkologii Laryngologicznej II Katedry Otolaryngologii UM w Łodzi
    Otolaryngol Pol 66:337-41. 2012
    ..The aim of this work was to evaluate the efficiency of kinesitherapy in the patients with mixed-type vertigo...
  101. pmc Intralabyrinthine schwannoma affecting the low but not high frequency function of the vestibulo-ocular reflex: implications for the clinical diagnosis of chronic peripheral vestibular deficits
    B Machner
    J Neurol Neurosurg Psychiatry 78:772-4. 2007

Research Grants25

  1. ENVIRONMENT INFLUENCES UPON AUDITORY DEVELOPMENT
    Allen Ryan; Fiscal Year: 2006
    ..1, and of Brn-3.1 domains that are critical for hair cell development and survival, are critical steps in understanding the role of this gene in inherited deafness. ..
  2. Conference on the Molecular Biology of Hearing/Deafness
    Allen Ryan; Fiscal Year: 2004
    ..Partial support is requested to defray travel costs of invited participants and to permit a registration fee low enough to encourage participation by junior faculty, postdoctoral fellows and students. ..
  3. CNS REMYELINATION BY GENETICALLY-MODIFIED T CELLS
    VINCENT TUOHY; Fiscal Year: 2002
    ..abstract_text> ..
  4. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
    ....
  5. VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICIN
    John Carey; Fiscal Year: 2005
    ..Johns Hopkins is uniquely suited to this training because it has a core group devoted to vestibular research, and the mentor's laboratory has successfully used all of the techniques required. ..
  6. Otitis Media Impact on the Inner Ear
    Dennis Trune; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Regulation of auditory neuron neurite growth by activity
    Marlan Hansen; Fiscal Year: 2008
    ..The results of these studies will provide critical data on the consequences of electrical activity on SGN neurite growth and cochlear innervation. ..
  8. Genetic Polymorphisms in Rheumatoid Arthritis
    Eric Matteson; Fiscal Year: 2004
    ..The mentorship program proposed in this grant is critical to this long-term goal. ..
  9. NOVEL USE OF ZEBRAFISH FOR APOPTOSIS ASSAY
    Chuenlei Parng; Fiscal Year: 2004
    ..Complementary visual and flow cytometry based assays will also be developed to provide comprehensive analysis of apoptosis in zebrafish. ..
  10. CONNEXINS AND THEIR ROLE IN EPIDERMAL DIFFERENTIATION
    Gabriele Richard; Fiscal Year: 2004
    ..We expect that these approaches provide critical information on the patho-mechanism of connexin defects in skin. ..
  11. Ninth Symposium on Cochlear Implants for Children
    John Niparko; Fiscal Year: 2003
    ..250) presentations. Panel discussions (n=3) will be scheduled, as will technical updates (n=3). Proceedings of the 9th Symposium will be published in the Archives of Otolaryngology-Head & Neck Surgery. ..
  12. DISEASE MECHANISMS IN ASNHL AND ITS MOUSE MODEL
    Vincent K Tuohy; Fiscal Year: 2010
    ..abstract_text> ..
  13. THE EPITOPE SPREADING CASCADE IN PROGRESSION OF EAE
    VINCENT TUOHY; Fiscal Year: 2005
    ..abstract_text> ..
  14. Evalution of Vestibular Function in Meniere's Disease
    John Carey; Fiscal Year: 2009
    ..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..
  15. GENDER-BASED REGULATION OF AUTOIMMUNE MEMORY
    VINCENT TUOHY; Fiscal Year: 2005
    ..Such information may ultimately serve as a basis for therapeutic intervention during the development of autoimmune disease. ..
  16. Zebrafish Screen for Neuroprotective Anti-oxidants
    Chuenlei Parng; Fiscal Year: 2005
    ..Assessment of drug effects in a convenient vertebrate model, prior to evaluation in a complex system, such as mouse, can potentially streamline the drug development process and dramatically reduce costs. ..
  17. Cardiotoxicity Drug Screening Using Zebrafish
    Chuenlei Parng; Fiscal Year: 2004
    ..Zebrafish drug screens can serve as an intermediate step between cell-based and mammalian testing, streamlining the drug development timeline. ..
  18. Vestibular Recovery after Intratympanic Gentamicin
    John Carey; Fiscal Year: 2004
    ..Furthermore, the mechanisms of vestibular recovery may help us understand the potential for the inner ear to recover from a variety of injuries. ..
  19. Genetic Analysis of Age Related Hearing Impairment
    Rick A Friedman; Fiscal Year: 2010
    ..This improved knowledge base can be anticipated to constitute fertile ground for developing new evidence-based preventive and therapeutic approaches to treating ARHI. ..
  20. Triceps acoustically evoked myogenic potential
    MARCELLO CHERCHI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  21. Differential Gene Expression in the Cochlear Nucleus
    David Friedland; Fiscal Year: 2008
    ..These data will also provide a powerful template upon which to test and design novel treatments for improving hearing, discrimination and tinnitus in a significant portion of the population. ..
  22. CLINICAL AND GENETIC STUDIES OF NETHERTON SYNDROME
    Gabriele Richard; Fiscal Year: 2002
    ....
  23. Study of a genetic network involved in ear development
    Rick Friedman; Fiscal Year: 2005
    ..These and future experiments represent the natural progression from my Mentored Clinical Scientist Development Award (K08). ..
  24. ASSAY FOR DETERMINING DRUG TOXICITY
    Chuenlei Parng; Fiscal Year: 2004
    ..abstract_text> ..