tinnitus

Summary

Summary: A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.

Top Publications

  1. ncbi The neuroscience of tinnitus
    Jos J Eggermont
    Department of Physiology and Biophysics, and Department of Psychology, University of Calgary, Alberta, Canada T2N 1N4
    Trends Neurosci 27:676-82. 2004
  2. pmc Tuning out the noise: limbic-auditory interactions in tinnitus
    Josef P Rauschecker
    Laboratory of Integrative Neuroscience and Cognition, Georgetown University Medical Center, Washington, DC 20057 1460, USA
    Neuron 66:819-26. 2010
  3. ncbi Prevalence and characteristics of tinnitus among US adults
    Josef Shargorodsky
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Mass, USA
    Am J Med 123:711-8. 2010
  4. ncbi Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model
    Roland Schaette
    University College London Ear Institute, London WC1X 8EE, United Kingdom
    J Neurosci 31:13452-7. 2011
  5. ncbi The neural code of auditory phantom perception
    Nathan Weisz
    Department of Psychology, University of Konstanz, D 78464 Konstanz, Germany
    J Neurosci 27:1479-84. 2007
  6. pmc Dysregulation of limbic and auditory networks in tinnitus
    Amber M Leaver
    Georgetown University Medical Center, Washington, DC 20057, USA
    Neuron 69:33-43. 2011
  7. pmc Phantom percepts: tinnitus and pain as persisting aversive memory networks
    Dirk De Ridder
    Tinnitus Research Initiative, Brain Research Center Antwerp for Innovative and Interdisciplinary Neuromodulation, and Department of Neurosurgery, University Hospital Antwerp, 2650 Edegem, Belgium
    Proc Natl Acad Sci U S A 108:8075-80. 2011
  8. pmc Ringing ears: the neuroscience of tinnitus
    Larry E Roberts
    Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Neurosci 30:14972-9. 2010
  9. pmc Reversing pathological neural activity using targeted plasticity
    Navzer D Engineer
    Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, USA
    Nature 470:101-4. 2011
  10. pmc Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex
    Elsa van der Loo
    Brain Research centre Antwerp for Innovative and Interdisciplinary Neuromodulation BRAI 2 N, University Hospital Antwerp, Antwerp, Belgium
    PLoS ONE 4:e7396. 2009

Detail Information

Publications325 found, 100 shown here

  1. ncbi The neuroscience of tinnitus
    Jos J Eggermont
    Department of Physiology and Biophysics, and Department of Psychology, University of Calgary, Alberta, Canada T2N 1N4
    Trends Neurosci 27:676-82. 2004
    b>Tinnitus is an auditory phantom sensation (ringing of the ears) experienced when no external sound is present. Most but not all cases are associated with hearing loss induced by noise exposure or aging...
  2. pmc Tuning out the noise: limbic-auditory interactions in tinnitus
    Josef P Rauschecker
    Laboratory of Integrative Neuroscience and Cognition, Georgetown University Medical Center, Washington, DC 20057 1460, USA
    Neuron 66:819-26. 2010
    b>Tinnitus, the most common auditory disorder, affects about 40 million people in the United States alone, and its incidence is rising due to an aging population and increasing noise exposure...
  3. ncbi Prevalence and characteristics of tinnitus among US adults
    Josef Shargorodsky
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Mass, USA
    Am J Med 123:711-8. 2010
    b>Tinnitus is common; however, few risk factors for tinnitus are known.
  4. ncbi Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model
    Roland Schaette
    University College London Ear Institute, London WC1X 8EE, United Kingdom
    J Neurosci 31:13452-7. 2011
    Ever since Pliny the Elder coined the term tinnitus, the perception of sound in the absence of an external sound source has remained enigmatic...
  5. ncbi The neural code of auditory phantom perception
    Nathan Weisz
    Department of Psychology, University of Konstanz, D 78464 Konstanz, Germany
    J Neurosci 27:1479-84. 2007
    b>Tinnitus is defined by an auditory perception in the absence of an external source of sound. This condition provides the distinctive possibility of extracting neural coding of perceptual representation...
  6. pmc Dysregulation of limbic and auditory networks in tinnitus
    Amber M Leaver
    Georgetown University Medical Center, Washington, DC 20057, USA
    Neuron 69:33-43. 2011
    b>Tinnitus is a common disorder characterized by ringing in the ear in the absence of sound. Converging evidence suggests that tinnitus pathophysiology involves damage to peripheral and/or central auditory pathways...
  7. pmc Phantom percepts: tinnitus and pain as persisting aversive memory networks
    Dirk De Ridder
    Tinnitus Research Initiative, Brain Research Center Antwerp for Innovative and Interdisciplinary Neuromodulation, and Department of Neurosurgery, University Hospital Antwerp, 2650 Edegem, Belgium
    Proc Natl Acad Sci U S A 108:8075-80. 2011
    ..Thus, different dynamic overlapping brain networks should be considered as targets for the treatment of this disorder...
  8. pmc Ringing ears: the neuroscience of tinnitus
    Larry E Roberts
    Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Neurosci 30:14972-9. 2010
    b>Tinnitus is a phantom sound (ringing of the ears) that affects quality of life for millions around the world and is associated in most cases with hearing impairment...
  9. pmc Reversing pathological neural activity using targeted plasticity
    Navzer D Engineer
    Cortical Plasticity Laboratory, Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas 75080, USA
    Nature 470:101-4. 2011
    ..can generate pathological neural activity that is believed to be responsible for many types of chronic pain and tinnitus. Several studies have reported that the severity of chronic pain and tinnitus is correlated with the degree of ..
  10. pmc Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex
    Elsa van der Loo
    Brain Research centre Antwerp for Innovative and Interdisciplinary Neuromodulation BRAI 2 N, University Hospital Antwerp, Antwerp, Belgium
    PLoS ONE 4:e7396. 2009
    Non-pulsatile tinnitus is considered a subjective auditory phantom phenomenon present in 10 to 15% of the population. Tinnitus as a phantom phenomenon is related to hyperactivity and reorganization of the auditory cortex...
  11. ncbi Neural correlates of tinnitus duration and distress: a positron emission tomography study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University Regensburg, Germany
    Hum Brain Mapp 34:233-40. 2013
    Cerebral (18)F-deoxyglucose positron emission tomography (FDG-PET) has shown altered auditory pathway activity in tinnitus. However, the corresponding studies involved only small samples and analyses were restricted to the auditory cortex ..
  12. ncbi Neural activity underlying tinnitus generation: results from PET and fMRI
    C P Lanting
    Department of Otorhinolaryngology Head and Neck Surgery, University Medical Center Groningen, The Netherlands
    Hear Res 255:1-13. 2009
    b>Tinnitus is the percept of sound that is not related to an acoustic source outside the body. For many forms of tinnitus, mechanisms in the central nervous system are believed to play an important role in the pathology...
  13. pmc Tinnitus: Models and mechanisms
    James A Kaltenbach
    Department of Neurosciences, NE 63, Lerner Research Institute Head and Neck Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44122, USA
    Hear Res 276:52-60. 2011
    Over the past decade, there has been a burgeoning of scientific interest in the neurobiological origins of tinnitus. During this period, numerous behavioral and physiological animal models have been developed which have yielded major ..
  14. ncbi Predicting tinnitus pitch from patients' audiograms with a computational model for the development of neuronal hyperactivity
    Roland Schaette
    Institute for Theoretical Biology, Department of Biology, Humboldt Universitat zu Berlin, Berlin
    J Neurophysiol 101:3042-52. 2009
    b>Tinnitus is often related to hearing loss, but how hearing loss could lead to tinnitus has remained unclear...
  15. ncbi Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus
    T J Brozoski
    Division of Otolaryngology, Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
    J Neurosci 22:2383-90. 2002
    Chinchillas with psychophysical evidence of chronic tinnitus were shown to have significantly elevated spontaneous activity and stimulus-evoked responses in putative fusiform cells of the dorsal cochlear nuclei (DCN)...
  16. ncbi The mechanisms of tinnitus: perspectives from human functional neuroimaging
    Peyman Adjamian
    MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, United Kingdom
    Hear Res 253:15-31. 2009
    ..contribution of advances in human neuroimaging to the current understanding of central mechanisms underpinning tinnitus and explain how interpretations of neuroimaging data have been guided by animal models...
  17. ncbi Structural brain changes in tinnitus: grey matter decrease in auditory and non-auditory brain areas
    Michael Landgrebe
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany
    Neuroimage 46:213-8. 2009
    b>Tinnitus, the phantom perception of sound, is a frequent disorder that causes significant morbidity. The pathophysiological mechanisms involved in tinnitus generation are still under exploration...
  18. pmc Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography
    Nathan Weisz
    Department of Psychology, University of Konstanz, Germany
    PLoS Med 2:e153. 2005
    The neurophysiological mechanisms underlying tinnitus perception are not well understood...
  19. ncbi Auditory cortex is implicated in tinnitus distress: a voxel-based morphometry study
    Martin Schecklmann
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany
    Brain Struct Funct 218:1061-70. 2013
    Neuroimaging studies of tinnitus suggest the involvement of wide-spread neural networks for perceptual, attentional, memory, and emotional processes encompassing auditory, frontal, parietal, and limbic areas...
  20. ncbi A randomized controlled trial of Internet-delivered cognitive behavior therapy and acceptance and commitment therapy in the treatment of tinnitus
    Hugo Hesser
    Department of Behavioural Sciences and Learning, Linnaeus Centre HEAD, Swedish Institute for Disability Research, Linkoping University, Linkoping, Sweden
    J Consult Clin Psychol 80:649-61. 2012
    Our aim in this randomized controlled trial was to investigate the effects on global tinnitus severity of 2 Internet-delivered psychological treatments, acceptance and commitment therapy (ACT) and cognitive behavior therapy (CBT), in ..
  21. ncbi Psychoacoustic characterization of the tinnitus spectrum: implications for the underlying mechanisms of tinnitus
    Arnaud Norena
    Laboratoire Neurosciences et Systemes Sensoriels, Hopital Edouard Herriot, CNRS UMR 5020, Lyon, France
    Audiol Neurootol 7:358-69. 2002
    ..was used in order to characterize in more detail than in previous studies the different perceptual components of tinnitus, i.e. auditory sensations which are perceived in the absence of a corresponding external acoustic stimulus...
  22. ncbi The association between tinnitus and mental health in a general population sample: results from the HUNT Study
    Norun Hjertager Krog
    Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway
    J Psychosom Res 69:289-98. 2010
    Clinical studies indicate a strong association between tinnitus and mental health, but results from general population data are missing...
  23. pmc Plasticity at glycinergic synapses in dorsal cochlear nucleus of rats with behavioral evidence of tinnitus
    H Wang
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794 9629, USA
    Neuroscience 164:747-59. 2009
    Fifteen percent to 35% of the United States population experiences tinnitus, a subjective "ringing in the ears". Up to 10% of those afflicted report severe and disabling symptoms...
  24. pmc Residual inhibition functions overlap tinnitus spectra and the region of auditory threshold shift
    Larry E Roberts
    Department of Psychology, Neuroscience, and Behaviour, McMaster University, 1280 Main Street West, Hamilton, ON, Canada, L8S 4K1
    J Assoc Res Otolaryngol 9:417-35. 2008
    ..In humans with tinnitus accompanied by hearing loss, this process may generate a phantom sound that is perceived in accordance with the ..
  25. ncbi High-frequency tinnitus without hearing loss does not mean absence of deafferentation
    Nathan Weisz
    Department of Psychology, University of Konstanz, Germany
    Hear Res 222:108-14. 2006
    A broad consensus within the neuroscience of tinnitus holds that this audiologic condition is triggered by central deafferentation, mostly due to cochlear damage...
  26. ncbi Real-time fMRI feedback training may improve chronic tinnitus
    Sven Haller
    Institute of Radiology, Department of Neuroradiology, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Radiol 20:696-703. 2010
    b>Tinnitus consists of a more or less constant aversive tone or noise and is associated with excess auditory activation. Transient distortion of this activation (repetitive transcranial magnetic stimulation, rTMS) may improve tinnitus...
  27. pmc Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus--possible basis for tinnitus-related hyperactivity?
    Susanne Dehmel
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:1660-71. 2012
    ..2008; Zeng et al., 2009). Given the well described connection between the somatosensory system and tinnitus in patients we sought to determine whether plastic changes in long-lasting bimodal somatosensory-auditory ..
  28. pmc Auditory resting-state network connectivity in tinnitus: a functional MRI study
    Audrey Maudoux
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    PLoS ONE 7:e36222. 2012
    The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients...
  29. ncbi The tinnitus functional index: development of a new clinical measure for chronic, intrusive tinnitus
    Mary B Meikle
    Oregon Health and Science University, Portland, Oregon 97207, USA
    Ear Hear 33:153-76. 2012
    Chronic subjective tinnitus is a prevalent condition that causes significant distress to millions of Americans...
  30. pmc Inhibitory neurotransmission in animal models of tinnitus: maladaptive plasticity
    Hongning Wang
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Hear Res 279:111-7. 2011
    b>Tinnitus is a phantom auditory sensation experienced by up to 14% of the United States population with a smaller percentage experiencing decreased quality of life...
  31. ncbi Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study
    Elmar Frank
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053, Regensburg, Germany
    J Neurol 259:327-33. 2012
    b>Tinnitus is the perception of sound in the absence of an environmental sound source. Abnormal activity in central auditory pathways is considered as the neuronal correlate of tinnitus...
  32. pmc The distressed brain: a group blind source separation analysis on tinnitus
    Dirk De Ridder
    BRAI2N, TRI and Department of Neurosurgery, Antwerp University Hospital, Antwerp, Belgium
    PLoS ONE 6:e24273. 2011
    b>Tinnitus, the perception of a sound without an external sound source, can lead to variable amounts of distress.
  33. ncbi Development of tinnitus-related neuronal hyperactivity through homeostatic plasticity after hearing loss: a computational model
    Roland Schaette
    Department of Biology, Institute for Theoretical Biology, Humboldt Universitat zu Berlin, Invalidenstr 43, 10115 Berlin, Germany
    Eur J Neurosci 23:3124-38. 2006
    b>Tinnitus, the perception of a sound in the absence of acoustic stimulation, is often associated with hearing loss...
  34. ncbi Activity in the dorsal cochlear nucleus of hamsters previously tested for tinnitus following intense tone exposure
    James A Kaltenbach
    Department of Otolaryngology, 5E UHC, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurosci Lett 355:121-5. 2004
    ..been hypothesized that this hyperactivity may represent a neural code that could underlie the sound percepts of tinnitus. The goal of the present study was to determine whether hyperactivity could be demonstrated in animals that had ..
  35. pmc Mapping cortical hubs in tinnitus
    Winfried Schlee
    Department of Psychology, University of Konstanz, Germany
    BMC Biol 7:80. 2009
    Subjective tinnitus is the perception of a sound in the absence of any physical source. It has been shown that tinnitus is associated with hyperactivity of the auditory cortices...
  36. ncbi An integrative model of tinnitus based on a central gain controlling neural sensitivity
    Arnaud Jean Noreña
    National Center of Scientific Research, Universite de Provence, Integrative and Adaptive Neurobiology Laboratory, Universite de Provence, Centre Saint Charles Case B, 3, Place Victor Hugo, 13333 Marseille Cedex, France
    Neurosci Biobehav Rev 35:1089-109. 2011
    ..is to propose a model highlighting the putative connections between hearing loss and the phantom perception of tinnitus (tinnitus being accompanied by hearing loss in the majority, if not all, subjects)...
  37. pmc Tinnitus, diminished sound-level tolerance, and elevated auditory activity in humans with clinically normal hearing sensitivity
    Jianwen Wendy Gu
    Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    J Neurophysiol 104:3361-70. 2010
    ..We report physiological correlates of two perceptual abnormalities in the auditory domain: tinnitus, the phantom perception of sound, and hyperacusis, a decreased tolerance of sound based on loudness...
  38. pmc Re-examining the relationship between audiometric profile and tinnitus pitch
    Magdalena Sereda
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    Int J Audiol 50:303-12. 2011
    We explored the relationship between audiogram shape and tinnitus pitch to answer questions arising from neurophysiological models of tinnitus: 'Is the dominant tinnitus pitch associated with the edge of hearing loss?' and 'Is such a ..
  39. pmc Homeostatic plasticity drives tinnitus perception in an animal model
    Sungchil Yang
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 108:14974-9. 2011
    Hearing loss often results in tinnitus and auditory cortical map changes, leading to the prevailing view that the phantom perception is associated with cortical reorganization...
  40. ncbi The neural correlates of tinnitus-related distress
    Sven Vanneste
    Brai 2 n, TRI and Department of Neurosurgery, University Hospital Antwerp, Belgium
    Neuroimage 52:470-80. 2010
    b>Tinnitus is an auditory phantom percept with a tone, hissing, or buzzing sound in the absence of any objective physical sound source...
  41. pmc Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition
    Jason W Middleton
    Department of Otolaryngology, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 108:7601-6. 2011
    b>Tinnitus has been associated with increased spontaneous and evoked activity, increased neural synchrony, and reorganization of tonotopic maps of auditory nuclei...
  42. ncbi Tinnitus and depression
    Berthold Langguth
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    World J Biol Psychiatry 12:489-500. 2011
    Depressive symptoms are common in individuals with tinnitus and may substantially aggravate their distress. The mechanisms, however, by which depression and tinnitus mutually interact are still not fully understood.
  43. ncbi Salicylate induces tinnitus through activation of cochlear NMDA receptors
    Matthieu J Guitton
    Institut National de la Santé et de la Recherche Médicale UR 254, Laboratoire de Neurobiologie de l Audition Plasticité Synaptique, Faculte de Medecine, Universite de Montpellier 1, 34090 Montpellier, France
    J Neurosci 23:3944-52. 2003
    Salicylate, the active component of aspirin, is known to induce tinnitus. However, the site and the mechanism of generation of tinnitus induced by salicylate remains unclear...
  44. pmc Methodological aspects of clinical trials in tinnitus: a proposal for an international standard
    Michael Landgrebe
    Department of Psychiatry and Psychotherapy, University of Regensburg, Germany
    J Psychosom Res 73:112-21. 2012
    Chronic tinnitus is a common condition with a high burden of disease...
  45. pmc Neuromagnetic indicators of tinnitus and tinnitus masking in patients with and without hearing loss
    Peyman Adjamian
    MRC Institute of Hearing Research, University Park, Nottingham, UK NG7 2RD
    J Assoc Res Otolaryngol 13:715-31. 2012
    b>Tinnitus is an auditory phenomenon characterised by the perception of a sound in the absence of an external auditory stimulus...
  46. ncbi Neuroanatomical correlates of tinnitus revealed by cortical thickness analysis and diffusion tensor imaging
    Faten M Aldhafeeri
    Department of Medical Imaging, School of Health Sciences, The University of Liverpool, Thompson Yates Building, Liverpool, L69 3GB, UK
    Neuroradiology 54:883-92. 2012
    b>Tinnitus is a poorly understood auditory perception of sound in the absence of external stimuli. Convergent evidence proposes that tinnitus perception involves brain structural alterations as part of its pathophysiology...
  47. ncbi Classification and epidemiology of tinnitus
    Andrew J Heller
    Department of Otolaryngology Head and Neck Surgery, Virginia Commonwealth University, Medical College of Virginia Hospitals, PO Box 980146, Richmond, VA 23298, USA
    Otolaryngol Clin North Am 36:239-48. 2003
    One third of all adults report experiencing tinnitus at some time in their lives. Ten percent to 15% have prolonged tinnitus requiring medical evaluation...
  48. ncbi Expression of c-fos in auditory and non-auditory brain regions of the gerbil after manipulations that induce tinnitus
    E Wallhäusser-Franke
    Department of Neuroacoustics, Institute of Zoology, Darmstadt University of Technology, Schnittspahnstr 3, 64287 Darmstadt, Germany
    Exp Brain Res 153:649-54. 2003
    Subjective tinnitus is a phantom sound sensation that does not result from acoustic stimulation and is audible to the affected subject only...
  49. ncbi Central tinnitus and lateral inhibition: an auditory brainstem model
    G M Gerken
    University of Texas at Dallas, Callier Center for Communication Disorders 75235, USA
    Hear Res 97:75-83. 1996
    Central tinnitus is used herein either to designate a tinnitus that originates in the central auditory system, or to refer to a component of a peripherally generated tinnitus that is exaggerated by auditory brain mechanisms...
  50. ncbi The neural network of phantom sound changes over time: a comparison between recent-onset and chronic tinnitus patients
    Sven Vanneste
    TRI Tinnitus Clinic, Brai n, TRI and Department of Neurosurgery, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium
    Eur J Neurosci 34:718-31. 2011
    b>Tinnitus is characterized by an ongoing conscious perception of a sound in the absence of any external sound source. Chronic tinnitus is notoriously characterized by its resistance to treatment...
  51. ncbi Changes in spontaneous neural activity immediately after an acoustic trauma: implications for neural correlates of tinnitus
    A J Noreña
    Department of Physiology and Biophysics, Neuroscience Research Group, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4
    Hear Res 183:137-53. 2003
    ..Moreover, rho was elevated in the Be-Ab2, Ab1-Ab2 and Ab2-Ab2 groups; this increase was significantly correlated to the changes in SFR. The results are discussed in the context of a neural correlate of tinnitus.
  52. ncbi Changes in spontaneous firing rate and neural synchrony in cat primary auditory cortex after localized tone-induced hearing loss
    Satoshi Seki
    Departments of Physiology and Biophysics, and Psychology, University of Calgary, 2500 University Drive N W, Calgary, AB, Canada T2N 1N4
    Hear Res 180:28-38. 2003
    ..neural activity after noise-induced hearing loss has frequently been associated with the phenomenon of tinnitus. Eighteen juvenile and adult cats were exposed for 2 h to a 6 kHz tone with an intensity of 115 dB SPL at the cat'..
  53. pmc The Tinnitus Research Initiative (TRI) database: a new approach for delineation of tinnitus subtypes and generation of predictors for treatment outcome
    Michael Landgrebe
    Department of Psychiatry, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany
    BMC Med Inform Decis Mak 10:42. 2010
    b>Tinnitus, the phantom perception of sound, is a frequent disorder that causes significant morbidity and treatment is elusive. A large variety of different treatment options have been proposed and from most of them some patients benefit...
  54. ncbi Tinnitus
    Alan H Lockwood
    Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA
    N Engl J Med 347:904-10. 2002
  55. ncbi Structural brain changes in tinnitus
    M Mühlau
    Department of Neurology, Technische Universitat Munchen, D 81675 Munchen, Germany
    Cereb Cortex 16:1283-8. 2006
    b>Tinnitus is a common but poorly understood disorder characterized by ringing or buzzing in the ear...
  56. ncbi Gap detection deficits in rats with tinnitus: a potential novel screening tool
    Jeremy G Turner
    Department of Surgery OtolaryngologySouthern Illinois University School of Medicine, Springfield, IL 62794 9629, USA
    Behav Neurosci 120:188-95. 2006
    The study describes a novel method for tinnitus screening in rats by use of gap detection reflex procedures...
  57. ncbi Is it the sound or your relationship to it? The role of acceptance in predicting tinnitus impact
    Vendela Westin
    Department of Behavioural Sciences and Learning, Swedish Institute for Disability Research, Linkoping University, SE 58183 Linkoping, Sweden
    Behav Res Ther 46:1259-65. 2008
    b>Tinnitus is an experience of sound in the absence of an appropriate external source...
  58. ncbi Primary afferent dendrite degeneration as a cause of tinnitus
    Carol A Bauer
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    J Neurosci Res 85:1489-98. 2007
    Chronic tinnitus affects millions of people, but the mechanisms responsible for the development of this abnormal sensory state remain poorly understood...
  59. pmc Neuroanatomical changes due to hearing loss and chronic tinnitus: a combined VBM and DTI study
    Fatima T Husain
    Department of Speech and Hearing Science, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Brain Res 1369:74-88. 2011
    Subjective tinnitus is the perception of sound in the absence of an external source. Tinnitus is often accompanied by hearing loss but not everyone with hearing loss experiences tinnitus...
  60. pmc Single-subject oscillatory γ responses in tinnitus
    William Sedley
    Auditory Group, Institute of Neuroscience, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Brain 135:3089-100. 2012
    This study used magnetoencephalography to record oscillatory activity in a group of 17 patients with chronic tinnitus. Two methods, residual inhibition and residual excitation, were used to bring about transient changes in spontaneous ..
  61. pmc Altered networks in bothersome tinnitus: a functional connectivity study
    Harold Burton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St, Louis, Missouri 63110, USA
    BMC Neurosci 13:3. 2012
    The objective was to examine functional connectivity linked to the auditory system in patients with bothersome tinnitus. Activity was low frequency (< 0.1 Hz), spontaneous blood oxygenation level-dependent (BOLD) responses at rest...
  62. pmc Acupuncture at local and distant points for tinnitus: study protocol for a randomized controlled trial
    Guang Xia Shi
    Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China
    Trials 13:224. 2012
    b>Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment...
  63. ncbi Counteracting tinnitus by acoustic coordinated reset neuromodulation
    Peter A Tass
    Research Center Julich, Institute for Neuroscience and Medicine Neuromodulation INM 7, Julich, Germany
    Restor Neurol Neurosci 30:137-59. 2012
    Subjective tinnitus is associated with pathologic enhanced neuronal synchronization...
  64. ncbi Neural correlates of tinnitus related distress: an fMRI-study
    Dennis Golm
    Georg August University, Georg Elias Mueller Institute of Psychology, Department of Clinical Psychology and Psychotherapy, Gosslerstrasse 14, 37073 Goettingen, Germany
    Hear Res 295:87-99. 2013
    Chronic tinnitus affects approximately 5% of the population. Severe distress due to the phantom noise is experienced by 20% of the tinnitus patients. This distress cannot be predicted by psychoacoustic features of the tinnitus...
  65. pmc The gap-startle paradigm for tinnitus screening in animal models: limitations and optimization
    Edward Lobarinas
    Center for Hearing and Deafness, The State University of New York at Buffalo, 137 Cary Hall, Buffalo, NY 14214, USA
    Hear Res 295:150-60. 2013
    ..Neurosci., 120:188-195) introduced the gap-startle paradigm as a high-throughput method for tinnitus screening in rats...
  66. pmc The cerebellum as a novel tinnitus generator
    Carol A Bauer
    Southern Illinois University School of Medicine, P O Box 19662, Springfield, IL 62794 9662, USA
    Hear Res 295:130-9. 2013
    ..Recently it was shown that rats with psychophysical evidence of tinnitus had significantly elevated neural activity in the paraflocculus of the cerebellum (PFL), as indicated by ..
  67. ncbi Tinnitus-related neural activity: theories of generation, propagation, and centralization
    Arnaud J Noreña
    CNRS and University of Aix Marseille, Laboratory of Adaptive and Integrative Neuroscience, Fédération de Recherche 3C, 3 Place Victor Hugo, 13331 Marseille, France
    Hear Res 295:161-71. 2013
    The neuroscience of tinnitus represents an ideal model to explore central issues in brain functioning such as the formation of auditory percepts, in addition to opening up new treatment avenues for the condition in the long-term...
  68. ncbi Subcallosal brain structure: correlation with hearing threshold at supra-clinical frequencies (>8 kHz), but not with tinnitus
    Jennifer R Melcher
    Dept of Otology and Laryngology, Harvard Medical School, Boston MA, USA
    Hear Res 295:79-86. 2013
    This study tested for differences in brain structure between tinnitus and control subjects, focusing on a subcallosal brain region where striking differences have been inconsistently found previously...
  69. ncbi Tinnitus: therapeutic use of superficial brain stimulation
    Berthold Langguth
    Interdisciplinary Tinnitus Clinic, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany Electronic address
    Handb Clin Neurol 116:441-67. 2013
    b>Tinnitus is a common disorder and traditional treatment approaches such as medication, active or passive sound enhancement, and cognitive behavioral therapy have limited efficacy...
  70. ncbi Connectivity graph analysis of the auditory resting state network in tinnitus
    A Maudoux
    Coma Science Group, Cyclotron Research Center, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    Brain Res 1485:10-21. 2012
    Thirteen chronic tinnitus patients and fifteen age-matched healthy controls were studied on a 3T magnetic resonance imaging (MRI) scanner during resting condition (i.e. eyes closed, no task performance)...
  71. pmc Development of tinnitus in CBA/CaJ mice following sound exposure
    Ryan J Longenecker
    Department of Anatomy and Neurobiology, College of Medicine, Northeastern Ohio Universities, Rootstown, 44272, USA
    J Assoc Res Otolaryngol 12:647-58. 2011
    b>Tinnitus, the perception of a sound without an external acoustic source, is a complex perceptual phenomenon affecting the quality of life in 17% of the adult population...
  72. ncbi Specialised treatment based on cognitive behaviour therapy versus usual care for tinnitus: a randomised controlled trial
    Rilana F F Cima
    Clinical Psychological Science, Maastricht University, Maastricht, Netherlands
    Lancet 379:1951-9. 2012
    Up to 21% of adults will develop tinnitus, which is one of the most distressing and debilitating audiological problems. The absence of medical cures and standardised practice can lead to costly and prolonged treatment...
  73. pmc Functional MRI evidence for a role of ventral prefrontal cortex in tinnitus
    Anna Seydell-Greenwald
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington, DC 20007, USA
    Brain Res 1485:22-39. 2012
    It has long been known that subjective tinnitus, a constant or intermittent phantom sound perceived by 10 to 15% of the adult population, is not a purely auditory phenomenon but is also tied to limbic-related brain regions...
  74. pmc Disentangling depression and distress networks in the tinnitus brain
    Kathleen Joos
    BRAI2N, Tinnitus Research Initiative Clinic Antwerp, Department of Neurosurgery, University Hospital Antwerp, Belgium
    PLoS ONE 7:e40544. 2012
    b>Tinnitus is the continuous perception of an internal auditory stimulus. This permanent sound often affects a person's emotional state inducing distress and depressive feelings changes in 6-25% of the affected population...
  75. ncbi Mapping tinnitus-related brain activation: an activation-likelihood estimation metaanalysis of PET studies
    Jae Jin Song
    Brain, TRI and Department of Neurosurgery, University Hospital Antwerp, Antwerp, Belgium
    J Nucl Med 53:1550-7. 2012
    In tinnitus, PET and other functional imaging modalities have shown functional changes not only in the auditory cortex but also in nonauditory regions such as the limbic, frontal, and parietal areas...
  76. ncbi Rapid increases of gamma power in the auditory cortex following noise trauma in humans
    Magdalene Ortmann
    Institute for Biomagnetism and Biosignalanalysis, University of Munster, Munster, Germany
    Eur J Neurosci 33:568-75. 2011
    b>Tinnitus is an auditory perception in the absence of any external sound source. It has been suggested that tinnitus is related to enhanced synchronization of neuronal activity in the auditory cortex...
  77. ncbi Tinnitus and its effect on working memory and attention
    Susan Rossiter
    MARCS Auditory Laboratories, University of Western Sydney, South Penrith, New South Wales, Australia
    J Speech Lang Hear Res 49:150-60. 2006
    In 2 experiments, the assumption that continual orienting to tinnitus uses cognitive resources was investigated...
  78. ncbi Towards an objectification by classification of tinnitus
    A Norena
    Laboratoire Neurosciences et Systèmes Sensoriels CNRS UPRESA 5020, Hopital Edouard Herriot, Lyon, France
    Clin Neurophysiol 110:666-75. 1999
    The objectives of this study are to identify the presence of tinnitus and classify its different forms, in terms of changes in noise.
  79. pmc Bilateral dorsal cochlear nucleus lesions prevent acoustic-trauma induced tinnitus in an animal model
    Thomas Jeffrey Brozoski
    Division of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Assoc Res Otolaryngol 13:55-66. 2012
    Animal experiments suggest that chronic tinnitus ("ringing in the ears") may result from processes that overcompensate for lost afferent input...
  80. pmc Tinnitus suppression by low-rate electric stimulation and its electrophysiological mechanisms
    Fan Gang Zeng
    Department of Otolaryngology Head and Neck Surgery, 110 Medical Science E, University of California, Irvine, CA 92697 5320, USA
    Hear Res 277:61-6. 2011
    b>Tinnitus is a phantom sensation of sound in the absence of external stimulation. However, external stimulation, particularly electric stimulation via a cochlear implant, has been shown to suppress tinnitus...
  81. pmc Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model
    C A Bauer
    Department of Surgery, Southern Illinois University School of Medicine, Springfield 62794, USA
    J Assoc Res Otolaryngol 2:54-64. 2001
    Subjective tinnitus is a common and often debilitating disorder that is difficult to study because it is a perceptual state without an objective stimulus correlate...
  82. ncbi Unlearning tinnitus-related cerebral synchrony with acoustic coordinated reset stimulation: theoretical concept and modelling
    Peter A Tass
    Institute of Neuroscience and Medicine Neuromodulation INM 7, Research Center Julich, 52425 Julich, Germany
    Biol Cybern 106:27-36. 2012
    b>Tinnitus is a deafferentation-induced phantom phenomenon characterized by abnormal cerebral synchrony and connectivity...
  83. ncbi Acoustic stimulation treatments against tinnitus could be most effective when tinnitus pitch is within the stimulated frequency range
    Roland Schaette
    Institute for Theoretical Biology, Humboldt Universitat zu Berlin, Berlin, Germany
    Hear Res 269:95-101. 2010
    Acoustic stimulation with hearing aids or noise devices is frequently used in tinnitus therapy. However, such behind-the-ear devices are limited in their high-frequency output with an upper cut-off frequency of approximately 5-6 kHz...
  84. ncbi A spiking neuron model of cortical correlates of sensorineural hearing loss: Spontaneous firing, synchrony, and tinnitus
    Melissa Dominguez
    Neural Comput 18:2942-58. 2006
    ..b>Tinnitus, an auditory percept in the absence of sensory input, may arise under these circumstances as a result of plastic ..
  85. ncbi rTMS for the treatment of tinnitus: the role of neuronavigation for coil positioning
    B Langguth
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany
    Neurophysiol Clin 40:45-58. 2010
    b>Tinnitus affects 10% of the population, its pathophysiology remains incompletely understood, and treatment is elusive...
  86. pmc Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity
    Hidehiko Okamoto
    Institute for Biomagnetism and Biosignalanalysis, Westfalian Wilhelms University, Malmedyweg 15, Muenster, Germany
    Proc Natl Acad Sci U S A 107:1207-10. 2010
    Maladaptive auditory cortex reorganization may contribute to the generation and maintenance of tinnitus. Because cortical organization can be modified by behavioral training, we attempted to reduce tinnitus loudness by exposing chronic ..
  87. ncbi The relevance of spontaneous activity for the coding of the tinnitus sensation
    Nathan Weisz
    INSERM U821, Brain Dynamics and Cognition, Lyon, France
    Prog Brain Res 166:61-70. 2007
    ..neuronal activity of cell assemblies within the auditory cortex could be the underlying neural code of tinnitus. Such synchronous activity is reflected in the ongoing oscillatory activation pattern that can be recorded non-..
  88. ncbi Combined temporal and prefrontal transcranial magnetic stimulation for tinnitus treatment: a pilot study
    Tobias Kleinjung
    Department of Otorhinolaryngology, University of Regensburg, Regensburg, Germany
    Otolaryngol Head Neck Surg 138:497-501. 2008
    ..stimulation (rTMS) of the temporal cortex has been proposed as a new treatment strategy for patients with chronic tinnitus. However, functional abnormalities in tinnitus patients also involve brain structures used for attentional and ..
  89. ncbi General review of tinnitus: prevalence, mechanisms, effects, and management
    James A Henry
    Veterans Affairs Medical Center, Portland, OR 97207, USA
    J Speech Lang Hear Res 48:1204-35. 2005
    b>Tinnitus is an increasing health concern across all strata of the general population...
  90. pmc Abnormal resting-state cortical coupling in chronic tinnitus
    Winfried Schlee
    Department of Psychology, University of Konstanz, Konstanz, Germany
    BMC Neurosci 10:11. 2009
    Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source...
  91. ncbi Tinnitus and insomnia
    Tatjana Crönlein
    Sleep Disorders and Research Center, Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstr 84, 93053, Regensburg, Germany
    Prog Brain Res 166:227-33. 2007
    Sleep problems are common in individuals with tinnitus but it is not known if they can be seen as a reaction to the acoustic percept of tinnitus disturbing normal sleep, or if there are common causes...
  92. ncbi Assessment and amelioration of hyperacusis in tinnitus patients
    René Dauman
    Tinnitus Clinic, Department of Otolaryngology Head and Neck Surgery, Unit of Audiology, University Hospital of Bordeaux, University Victor Segalen Bordeaux 2, Bordeaux, France
    Acta Otolaryngol 125:503-9. 2005
    b>Tinnitus can be bothersome even without hyperacusis...
  93. ncbi Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats
    Guang Yang
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, University at Buffalo, Buffalo, NY 14214, USA
    Hear Res 226:244-53. 2007
    Neurophysiological studies of salicylate-induced tinnitus have generally been carried out under anesthesia, a condition that abolishes the perception of tinnitus and depresses neural activity...
  94. ncbi Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus
    Marion Smits
    Department of Radiology, Hs 224, Erasmus MC University Medical Center Rotterdam, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Neuroradiology 49:669-79. 2007
    b>Tinnitus is hypothesized to be an auditory phantom phenomenon resulting from spontaneous neuronal activity somewhere along the auditory pathway...
  95. ncbi Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006
    B Langguth
    Department of Psychiatry, University of Regensburg, Regensburg, Germany
    Prog Brain Res 166:525-36. 2007
    There is widespread recognition that consistency between research centres in the ways that patients with tinnitus are assessed and outcomes following interventions are measured would facilitate more effective co-operation and more ..
  96. ncbi Contralateral parahippocampal gamma-band activity determines noise-like tinnitus laterality: a region of interest analysis
    S Vanneste
    Brai n, TRI and Department of Neurosurgery, University Hospital Antwerp, Belgium
    Neuroscience 199:481-90. 2011
    b>Tinnitus is described as an auditory perception in the absence of any external sound source. Tinnitus loudness has been correlated to sustained high frequency gamma-band activity in auditory cortex...
  97. ncbi A systematic review and meta-analysis of randomized controlled trials of cognitive-behavioral therapy for tinnitus distress
    Hugo Hesser
    Department of Behavioural Sciences and Learning, Linnaeus Centre HEAD, Swedish Institute for Disability Research, Linkoping University, Sweden
    Clin Psychol Rev 31:545-53. 2011
    b>Tinnitus is defined as a sound in the ear(s) and/or head without external origin and is a serious health concern for millions worldwide...
  98. ncbi Acceptance and commitment therapy versus tinnitus retraining therapy in the treatment of tinnitus: a randomised controlled trial
    Vendela Zetterqvist Westin
    Department of Behavioural Sciences and Learning, Linkoping University, Linkoping, Sweden
    Behav Res Ther 49:737-47. 2011
    The study compared the effects of Acceptance and Commitment Therapy (ACT) with Tinnitus Retraining Therapy (TRT) on tinnitus impact in a randomised controlled trial...
  99. ncbi Navigated rTMS for the treatment of tinnitus: a pilot study with assessment by fMRI and AEPs
    J P Lefaucheur
    EA 4391, Faculte de Medecine, Université Paris Est Créteil, 94010 Creteil Cedex, France
    Neurophysiol Clin 42:95-109. 2012
    Repeated transcranial magnetic stimulation (rTMS) of auditory cortex has been proposed to treat refractory chronic tinnitus, but the involved mechanisms of action remain largely unknown...
  100. ncbi Current pharmacological treatments for tinnitus
    Berthold Langguth
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    Expert Opin Pharmacother 13:2495-509. 2012
    b>Tinnitus, the phantom perception of sound, is a highly prevalent disorder and treatment is elusive.
  101. pmc Behavioral evidence for possible simultaneous induction of hyperacusis and tinnitus following intense sound exposure
    G Chen
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    J Assoc Res Otolaryngol 14:413-24. 2013
    Many human subjects suffering from chronic tinnitus also suffer from hyperacusis, a heightened perception of loudness at moderate to intense sound levels...

Research Grants73

  1. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2013
    ..They cause significant morbidity including deafness, tinnitus, facial paralysis, imbalance, and brainstem compression...
  2. Genetic Susceptibility and Biomarkers of Platinum-related Toxicities
    Lois B Travis; Fiscal Year: 2013
    ..Long-term ototoxicity affects 19-77% of patients, with 35-65% developing tinnitus. Long-term sensory neuropathies affect 30-40% patients...
  3. Mechanisms of Cochlear Oxidative Stress Injury and Strategies to Protect Hearing
    Michael J Brenner; Fiscal Year: 2013
    ..but they are also associated with a risk of permanent, bilateral hearing loss, as well as balance disturbance, tinnitus, and nephrotoxicity...
  4. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
    ..the way to development of biochemical and genetic therapies for transmitter-related hearing loss, vertigo, and tinnitus. The possibility of biochemical/pharmacologic manipulation of afferent signaling in auditory/vestibular deficits ..
  5. Preclinical testing of a novel PDK1 inhibitor for treating vestibular schwannoma
    Abraham Jacob; Fiscal Year: 2013
    ..VS are intracranial tumors that cause sensorineural hearing loss, balance abnormalities, tinnitus, vertigo, facial weakness, hydrocephalus, seizures, blindness, and even death...
  6. Basic Mechanisms in Hearing Loss of Cochlear Origin
    Allen F Ryan; Fiscal Year: 2013
    ..The effects of SNHL on veterans'quality of life are substantial. SNHL and tinnitus also account for more disability compensation in the VA than any other disorder, and rehabilitation costs are ..
  7. Core Center for BioBehavioral Sciences of Communication Disorders
    Mabel L Rice; Fiscal Year: 2013
    ..clinical trials with a viral vector to induce regeneration of vestibular hair cells for the treatment of tinnitus/balance disorders, and gene regulation of axon growth related to cortical development...
  8. For Hearing Component in the Hispanic Community Health Study (HCHS)
    Lisa Lavange; Fiscal Year: 2009
    ..NIDCD is providing funding to support audiometry exams and questions relating to hearing loss/hearing aid use, tinnitus, noise exposure, and other factors that affect hearing thresholds...
  9. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
    b>Tinnitus, a mostly whistling, buzzing, or hissing phantom sound perceived in the absence of a corresponding external stimulus, is perceived by about 15% of the adult population, and about 75% of all patients with hearing loss...
  10. The role of cochlear pericytes in control of cochlear microcirculation
    Xiao Rui Shi; Fiscal Year: 2009
    ..serious hearing disorders including sudden sensorineural hearing loss, presbyacusis, noise-induced hearing loss, tinnitus, and certain vestibulopathies...
  11. Auditory Cortex Plasticity and Tinnitus
    Brian Allman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Tinnitus, a subjective perception of a phantom auditory sensation (e.g., ringing in the ears), affects approximately 10-15% of the general population...
  12. Telehealth Tinnitus Intervention for Patients with TBI
    JAMES A contact HENRY; Fiscal Year: 2011
    ..provided by applicant): Project Summary/Abstract Traumatic brain injury (TBI) is strongly associated with tinnitus. Tinnitus management for Veterans and military personnel with TBI has become a critical concern...
  13. Cholinergic inputs to excitatory and inhibitory midbrain auditory circuits
    JEFFREY GARRETT MELLOTT; Fiscal Year: 2013
    ..This may have important implications for normal function as well as dysfunction (such as presbycusis or tinnitus) associated with aging or injury and for the evolving design and use of cochlear implants and brainstem implants...
  14. Features of chronic tinnitus in an animal model as indicated by MEMRI and MRS
    BORIS M ODINTSOV; Fiscal Year: 2012
    The mechanisms responsible for chronic tinnitus are poorly understood...
  15. ANATOMY OF THE AUDITORY SYSTEM
    DONALD KENT MOREST; Fiscal Year: 2010
    ..The overall hypothesis is that these shifts provide a structural basis for tinnitus and hyperacusis after noise exposure...
  16. PHARMACOLOGY OF NEUROTRANSMITTERS IN HAIR CELL ORGANS
    William F Sewell; Fiscal Year: 2010
    ..for disorders in which these regulatory mechanism may be evoked, such as excitotoxic responses to trauma, tinnitus, and Meniere's syndrome...
  17. Electrophysiological mapping of corticocollicular projections involved with tonot
    HUBERT HYUNGIL LIM; Fiscal Year: 2013
    ..In some cases, the brain can experience abnormal plasticity. Hearing loss and tinnitus are two examples of debilitating conditions that affect millions of Americans and have been linked to abnormal ..
  18. Anatomical analysis of cortical projections to the auditory midbrain
    KYLE TOKUICHI NAKAMOTO; Fiscal Year: 2012
    ..This may have important implications for normal function as well as dysfunction (such as presbycusis or tinnitus) associated with aging or injury and for the evolving design and use of cochlear implants and brainstem implants...
  19. Ototoxicity protection with intratympanic steroid implant
    William H Slattery; Fiscal Year: 2012
    ..This can lead to permanent hearing loss and/or tinnitus (continuous ringing in the ear) in the patient...
  20. DEVELOPMENT OF A DRUG THERAPY TO AMELIORATE PERMANENT HEARING LOSS
    Jianxin Bao; Fiscal Year: 2010
    ..For example, if successful, a similar approach can be explored for the treatment of presbycusis and tinnitus. In summary, this proposal will develop a paradigm-shifting approach to test novel drug combinations against NIHL...
  21. Can noise-induced TTS cause persistent impairment of speech understanding?
    Anthony Brammer; Fiscal Year: 2013
    ..either report frequent exposure to noise and/or loud music and symptoms suggestive of noise-induced TTS and/or tinnitus ("exposed" group), or little or no exposure to noise or symptoms suggestive of noise-induced TTS or tinnitus ("..
  22. Cochlear Neurotransmitters
    William F Sewell; Fiscal Year: 2013
    ..For example, a greater understanding of the role NMDA receptors play in the cochlea could lead to new tinnitus therapies...
  23. DEVELOPMENT OF A DRUG THERAPY TO AMELIORATE PERMANENT HEARING LOSS
    Jianxin Bao; Fiscal Year: 2013
    ..For example, if successful, a similar approach can be explored for the treatment of presbycusis and tinnitus. In summary, this proposal will develop a paradigm-shifting approach to test novel drug combinations against NIHL. ..
  24. From infra- to ultrasound: Diversity in acoustic processing by the vertebrate ear
    Peter M Narins; Fiscal Year: 2010
    ..Ultimately, our research may lead to new therapeutic approaches to treatment of hyperacusis and noise-induced tinnitus, two known syndromes in which efferent system malfunction has been implicated.
  25. SINGLE-NEURON MARKING IN THE STUDY OF ABNORMAL COCHLEAS
    M Charles Liberman; Fiscal Year: 2013
    ..in the absence of olivocochlear (OC) feedback, and that selective low-SR fiber loss may lead to hyperacusis, tinnitus and hyperactivity in central circuits...
  26. Localization of cisplatin and cisplatin-binding proteins in the inner ear
    Peter S Steyger; Fiscal Year: 2010
    ..The proposed research will enable the development of new strategies to prevent cochlear uptake of cisplatin and its derivates and subsequent ototoxic sequelae, particularly life-long deafness, tinnitus and vestibular deficits.
  27. Effects of Cochlear Lesions on Thalamocortical Rhythms-Relationship to Tinnitus
    Daniel Stolzberg; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Summary Tinnitus is a disorder characterized by the perception of a phantom auditory sensation in the absence of an external source...
  28. Cellular regulation of cochlear blood flow
    A PHILINE WANGEMANN; Fiscal Year: 2012
    ..many hearing disorders, such as sensorineural hearing loss, acute acoustic trauma, noise-induced hearing loss, tinnitus, Meniere's disease and presbyacusis may be caused or aggravated by localized vasospasms that pathologically ..
  29. PHYSIOLOGY OF DORSAL COCHLEAR NUCLEUS MOLECULAR LAYER
    Paul B Manis; Fiscal Year: 2011
    ..Increased spontaneous activity in the DCN after hearing loss has also been associated with tinnitus. Increased electrical excitability or decreased inhibition could lead to increased activity of DCN neurons, are ..
  30. Biophysical Basis of Organization and Dynamics of Prestin Membrane Complexes
    Robert M Raphael; Fiscal Year: 2013
    ..including non-steroidal anti-inflammatory agents (NSAIDs), which are known to induce hearing loss and tinnitus. The sensitivity of human hearing depends on the proper function of a motor protein called prestin located in ..
  31. The effects of aging and hearing loss on human auditory cortex
    David L Woods; Fiscal Year: 2013
    ..the precision of neuroimaging studies of HAC that has been implicated in a variety of audiological, neurological and psychiatric disorders including tinnitus, stroke, dementia, autism, schizophrenia, and traumatic brain injury (TBI).
  32. Ion channels and presynaptic function of an auditory synapse
    Hai Huang; Fiscal Year: 2013
    ..which may have implications for neurological disorders that are characterized by persistent activity, such as tinnitus or epilepsy...
  33. Maintenace rTMS for chronic tinnitus relief
    Mark S Mennemeier; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Subjective tinnitus is perception of sound like ringing, buzzing, or hissing in the absence of external stimulation. Tinnitus is a significant neurological disorder that affects 51 million US citizens...
  34. G-protein-coupled Receptors in Hearing Physiology
    Yong Lu; Fiscal Year: 2012
    ..signal processing/temporal coding, and help lay the groundwork for decisions about possible therapeutic approaches to hearing defects related to altered synaptic transmission, such as dyslexia, tinnitus, and age-related hearing loss.
  35. Research Training for Clinical Audiologists
    WILLIAM WALTER CLARK; Fiscal Year: 2012
    ..and adults, language acquisition and speech perception in children with hearing impairment, hearing aids, tinnitus, diseases of the middle and inner ear, aural rehabilitation, and the basic sciences underlying these practice ..
  36. Optogenetic Population Clamp to Study Long-term Plasticity in Vitro
    Robert J Butera; Fiscal Year: 2013
    ..high-amplitude electrical discharges from population bursting can manifest as seizures, chronic pain, dystonia, tinnitus, or other disabling symptoms, depending on which part of the nervous system has become hyper-excitable after ..
  37. Epression of Ion Channels in the Auditory System
    Leonard K Kaczmarek; Fiscal Year: 2013
    ..stimuli is likely to lead to novel pharmacological treatments for disorders of auditory function including tinnitus, age-related hearing loss and audiogenic seizures, as well as Fragile X syndrome and other disorders of ..
  38. Preliminary Clinical Trial of New Therapy for Patients with Severe Tinnitus
    RUTH QUILLIAN WOLEVER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Tinnitus is a common problem for which there is no universally effective treatment...
  39. Pilot Clinical Trial of Deep Brain Stimulation for Tinnitus
    Paul Larson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tinnitus is a phantom auditory disorder that affects 10-15% of the general population...
  40. Function of Somatosensory Pathways to Cochlear Nucleus
    Susan E Shore; Fiscal Year: 2013
    ..alteration is enhanced after unilateral deafness and could explain why patients are able to modulate their tinnitus by somatic maneuvers such as jaw clenching...
  41. Eph-eprhin Signaling in Mapping Auditory Midbrain Circuitry
    MARK LAWRENCE GABRIELE; Fiscal Year: 2012
    ..of stimulation paradigms, thus guiding new treatment strategies for the hearing impaired and those suffering from tinnitus. PUBLIC HEALTH RELEVANCE: Hearing, performed by the auditory system, is a vital sense and critical for speech and ..
  42. High-Resolution Mapping of Susceptibility Genes for NIHL
    Rick A Friedman; Fiscal Year: 2013
    ..noise (subsonic) or sudden blast exposure (supersonic) leads to permanent and debilitating hearing loss and tinnitus. Pre-exposure diagnostics and the development of targeted therapies are sorely needed...
  43. Glial Influences on Auditory Brainstem Development
    Karina S Cramer; Fiscal Year: 2013
    ..Defects in central auditory circuitry can lead to language difficulties, problems with sound perception, or tinnitus. An understanding of how these networks are assembled during maturation will aid in the development of treatments ..
  44. American Academy of Audiology_Academy Research Conference_2011_2012_2013
    VICTORIA M KEETAY; Fiscal Year: 2013
    ..on April 6, 2011, in Chicago, Illinois, with a program on "Current Trends in the Evaluation and Treatment of Tinnitus." Tinnitus well represents the ARC's public health relevance...
  45. Synaptic physiology of unipolar brush cells in the dorsal cochlear nucleus
    Carolina M Glogowski; Fiscal Year: 2013
    ..Multisensory modulation of auditory input is a basic feature of the DCN and may be a critical contributor to tinnitus, a common hearing impairment disorders characterized by the perception of sound without exterior auditory ..
  46. Amygdalar modulation of processing in auditory cortex
    DIANA COOMES PETERSON; Fiscal Year: 2012
    ..They may also further our understanding of abnormal auditory perceptions such as tinnitus or the auditory hallucinations associated with psychiatric disorders such as schizophrenia and bipolar disorder.
  47. Safe Direct Current Neural Stimulation System
    GENE YEVGENY FRIDMAN; Fiscal Year: 2013
    ..Furthermore, several highly prevalent disorders characterized by high uncontrolled neural firing rates such as tinnitus, chronic pain, and epilepsy could be effectively treated by an implantable prosthesis capable of neural ..
  48. 2010 Auditory System Gordon Research Conference and Gordon Research Seminar
    Lisa V Goodrich; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Deafness and auditory processing disorders, such as tinnitus, affect millions of people...
  49. Tinnitus Retraining Therapy Trial
    Roberta W Scherer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Tinnitus Retraining Therapy Trial (TRTT) is a five-year study designed to investigate the efficacy of tinnitus retraining therapy (TRT) and its component parts, directive counseling (DC) and sound ..
  50. REGULATION OF SYNAPTIC AMINO ACID RECEPTORS
    Laurence O Trussell; Fiscal Year: 2010
    ..Moreover, this work may lend new clues to the treatment of tinnitus, a condition thought to be maintained by long-term plasticity in this brain region.
  51. Does strial microischemia enhance cochlear aminoglycoside ototoxicity
    Hongzhe Li; Fiscal Year: 2013
    ..e. strial micro-leakage. Cochlear ischemia alone may cause abrupt hearing loss and tinnitus. Combined strial micro-leakage and systemic administration of aminoglycoside antibiotics can escalate ..
  52. Auditory Information Processing in the Amygdala
    JEFFREY JAMES WENSTRUP; Fiscal Year: 2013
    ..between acoustic inputs and emotional responses in disorders such as autism, schizophrenia, post-traumatic stress, and tinnitus. This work lays groundwork for study of the function of the amygdala in animal models of these disorders.
  53. STUDIES OF THE COCHLEAR NUCLEUS GRANULE CELL DOMAIN
    David K Ryugo; Fiscal Year: 2010
    ..As we learn about how the somatosensory system modulates hearing, we will gain insight into somatic tinnitus that could contribute to the design of treatment strategies and a better understanding of tinnitus in general.
  54. Neuromodulation of midbrain frequency sensitivity by two serotonin receptors
    Laura M Hurley; Fiscal Year: 2012
    ..how the 5-HT1A and 5-HT1B receptors act to alter frequency filtering in the IC will lay the groundwork for addressing the role of serotonin in auditory dysfunctions such as poor speech perception, auditory hypersensitivity, or tinnitus.
  55. Functional Neuroimaging and Transcranial Magnetic Stimulation in Mal de Debarquem
    YOON HEE K CHA; Fiscal Year: 2012
    ..of many disorders characterized by maladaptive responses, most notably major depression, chronic pain, and tinnitus. Studies on tinnitus show that there is an area of heightened baseline activity in the auditory cortex and that ..
  56. Targeted Neural Plasticity for the Treatment of Tinnitus
    Richard S Tyler; Fiscal Year: 2013
    ..double-blind, sham-controlled partial cross-over interventional study to test safety and efficacy of our novel tinnitus therapy...
  57. Sensorimotor gating in humans with tinnitus and hyperacusis
    JENNIFER RENEE MELCHER; Fiscal Year: 2013
    ..of sensorimotor gating - the acoustic startle response (ASR) and prepulse inhibition (PPI) - in humans with tinnitus and hyperacusis is both important and timely...
  58. Understanding the Neural Mechanisms Responsible for Tinnitus
    ERIC DANIEL YOUNG; Fiscal Year: 2010
    ..Technologies and specific Challenge Topic, 06-DC-103* Understanding the Neural Mechanisms Responsible for Tinnitus. The proposed work investigates changes that occur in the auditory part of the brain after damage to the cochlea, ..
  59. Effectiveness of an Intervention to Prevent Hearing Loss Among Farmers
    Marjorie C McCullagh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hearing loss and tinnitus are prevalent in America, and noise exposure is a leading cause of hearing loss. This type of hearing loss is known as Noise-Induced Hearing Loss (NIHL)...
  60. Excitability and synaptic function of type II cochlear afferents
    Paul Fuchs; Fiscal Year: 2013
    ..Hearing loss can lead to hyperacusis and the phantom percept of tinnitus. The analogy to peripheral sensitization and 'phantom limb pain'prompts parallels with somatic ..
  61. The Necessity of Norepinephrine for Auditory Cortical Plasticity
    KATHRYN NANCY SHEPARD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Onset or treatment of audiological disorders such as dyslexia and tinnitus are associated with changes in neural activity in auditory cortex...
  62. Neural Mechanism Underlying Sound-Evoked Suppression of Tinnitus:Residual Inhibit
    ALEXANDER GALAZYUK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tinnitus, the perception of a sound without an external acoustic source, can be suppressed briefly following the offset of an external sound...
  63. Tribal Community-Based Prevention of Noise-Induced Hearing Loss and Tinnitus
    William Martin; Fiscal Year: 2007
    ..Noise-induced hearing loss (NIHL) and related tinnitus are significant health risks for the general population and Native Americans are likely to be at-risk because of ..
  64. Molecular neuroanatomy of the cochlear nucleus in deafness
    Maria E Rubio; Fiscal Year: 2010
    ..replace hearing (via cochlear implants) in cases of congenital deafness, and may lead to treatment paradigms for tinnitus. The proposed research will make novel contributions to the field of glutamatergic brain plasticity and auditory ..
  65. Ecological Momentary Assessment in Hearing Disorders
    James Henry; Fiscal Year: 2009
    The two most common auditory disorders among middle-aged Americans are hearing loss and tinnitus. Approximately 32% of those 55 years of age or older have self-reported hearing loss and about 8% of all adults currently report that they ..
  66. Intervention for Reduced Sound Tolerance
    C Formby; Fiscal Year: 2006
    ..e., hyperacusis) for hearing impaired persons. The novel intervention is an extension of Tinnitus Retraining Therapy (TRT), which uses directive counseling and low-level sound therapy to habituate the tinnitus ..
  67. GENE REGULATION OF RAT DENTIN SIALOPROTEIN
    HELENA RITCHIE; Fiscal Year: 2006
    ..Importantly, some DGI patients also experience tinnitus as well as balancing problems making it necessary to consider problems in DSP-PP transcript and protein ..
  68. COCHLEAR BLOOD FLOW AND NEUROPEPTIDES
    Alfred Nuttall; Fiscal Year: 2002
    The migraine related inner ear symptoms for phonopobia , tinnitus, hearing fluctuation, hearing loss, and increased noise sensitivity provide evidence for a possible neurological substrate connecting basilar artery migraine and cochlear ..
  69. Novel Inner Ear Drug Delivery System
    TOMASZ PETELENZ; Fiscal Year: 2002
    ..for treatment of middle ear and cochlear diseases, such as sudden hearing loss, Menieres disease, instances of tinnitus, and for providing pharmacological hearing protection in chemotherapy...
  70. Health Communication: NIHL and Tinnitus Prevention
    William Martin; Fiscal Year: 2006
    Noise-induced hearing loss (NIHL) and related tinnitus pose significant health risks to millions of Americans...
  71. Molecular Development of the Endolymphatic Duct and Sac
    Daniel Choo; Fiscal Year: 2005
    ..Failure to maintain endolymph homeostasis is thought to result in deafness, vestibular dysfunction and tinnitus in pathologies such as Meniere's disease or certain forms of hereditary hearing impairment...
  72. Cortical Electrical Suppression of Noise-Induced Tinnitus
    Jinsheng Zhang; Fiscal Year: 2010
    b>Tinnitus is a phantom sound that occurs in the absence of external stimulation. It can have debilitating effects on millions of patients, creating a significant economic impact on our society...
  73. Adenylyl Cyclase Signaling in Ear Sensory Eipthelia
    MARIAN DRESCHER; Fiscal Year: 2009
    ..The elucidation of these AC-mediated signal transduction pathways in inner ear sensory epithelia may allow eventual pharmacological amelioration of tinnitus, sensorinetiral deafness and vertigo.