Genomes and Genes
Summary: Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices, including the sensorineural pathways.
Publications243 found, 100 shown here
- Aminoglycoside induced ototoxicityO neil W Guthrie
Duke University, Department of Biology, Developmental, Cell and Molecular Biology DCMB Group, French Family Science Center, Durham, NC 27708 0338, USA
Toxicology 249:91-6. 2008..Animal experiments have provided encouraging evidence for the protection of cochlear hair cells and neurons from aminoglycoside toxicity. However, the extent to which such protection, generalize to human ototoxicity remains unresolved...
- The case for early identification of hearing loss in children. Auditory system development, experimental auditory deprivation, and development of speech perception and hearingY S Sininger
Children s Auditory Research and Evaluation Center, University of California Davis Medical Center, USA
Pediatr Clin North Am 46:1-14. 1999..All evidence regarding neural development supports such early intervention for maximum development of communication ability and hearing in infants...
- Prevalence of permanent childhood hearing impairment in the United Kingdom and implications for universal neonatal hearing screening: questionnaire based ascertainment studyH M Fortnum
MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD
BMJ 323:536-40. 2001..To estimate the prevalence of confirmed permanent childhood hearing impairment and its profile across age and degree of impairment in the United Kingdom...
- Antioxidant micronutrient impact on hearing disorders: concept, rationale, and evidenceGerald M Haase
University of Colorado, School of Medicine, Premier Micronutrient Corporation, Clinical Programs Center, Denver, Colorado, USA
Am J Otolaryngol 32:55-61. 2011..Therefore, considering appropriate biologic therapy as an adjunct to standard care against these damaging factors may provide rational expansion of treatment options for otolaryngologists and audiologists...
- Societal costs of hearing disorders: a systematic and critical review of literatureFrida Hjalte
The Swedish Institute for Health Economics, Lund, Sweden
Int J Audiol 51:655-62. 2012The objective of this study was to perform a critical and systematic literature review of studies on societal costs due to hearing disorders.
- A comparison of the quality of life of hearing-impaired people as estimated by three different utility measuresGarry R Barton
MRC Institute of Hearing Research, University Park, Nottingham, UK
Int J Audiol 44:157-63. 2005..36 to 0.58). This suggests that different utility measures will provide different estimates of the effectiveness of hearing aid provision...
- Molecular markers for cell types of the inner ear and candidate genes for hearing disordersS Heller
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
Proc Natl Acad Sci U S A 95:11400-5. 1998..and an ear-specific connexin, comprises proteins whose human equivalents are candidates to account for hearing disorders. This group also includes proteins expressed in two unique cell types of the inner ear, homogene cells and ..
- Assessment of hearing and hearing disorders in rock/jazz musiciansKim Kähärit
National Institute for Working Life West, Department of Audiology, Goteborg University, Goteborg, Sweden
Int J Audiol 42:279-88. 2003The aim of this study was to assess hearing and hearing disorders among rock/jazz musicians. One hundred and thirty-nine (43 women and 96 men) musicians participated...
- Nitric oxide--a versatile key player in cochlear function and hearing disordersUlf Rüdiger Heinrich
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Germany
Nitric Oxide 27:106-16. 2012..This review discusses potential cellular mechanisms how NO might contribute to different forms of hearing disorders. Approaches of NO-reduction are evaluated and the transfer of results obtained from experimental animal ..
- Neurotology of migraineR W Baloh
Department of Neurology, UCLA School of Medicine 90095-1769, USA
Headache 37:615-21. 1997..This hypothesis is currently being investigated in other families with migraine headaches and neurotologic symptoms. Hopefully, such studies will lead to improved diagnosis and better treatments in the future...
- Projected cost-effectiveness of statewide universal newborn hearing screeningRon Keren
Department of Medicine, Children s Hospital, Boston, Massachusetts, USA
Pediatrics 110:855-64. 2002....
- Reducing the burden of communication disorders in the developing world: an opportunity for the millennium development projectBolajoko O Olusanya
Institute of Child Health and Primary Care, College of Medicine, University of Lagos, Lagos, Nigeria
JAMA 296:441-4. 2006
- A systematic review of health-related quality of life and hearing aids: final report of the American Academy of Audiology Task Force On the Health-Related Quality of Life Benefits of Amplification in AdultsTheresa Hnath Chisolm
Department of Communication Sciences and Disorders, University of South Florida, Tampa, USA
J Am Acad Audiol 18:151-83. 2007..This review concludes that hearing aids improve adults' HRQoL by reducing psychological, social, and emotional effects of SNHL. Future studies should include control groups using randomized controlled trials...
- Auditory and visual orienting responses in listeners with and without hearing-impairmentW Owen Brimijoin
MRC Institute of Hearing, Research Scottish Section, Glasgow Royal Infirmary, Glasgow G31 2ER, United Kingdom
J Acoust Soc Am 127:3678-88. 2010....
- Cost and cost-effectiveness of universal screening for hearing loss in newbornsE J Kezirian
Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, 98195, USA
Otolaryngol Head Neck Surg 124:359-67. 2001..To estimate the cost and cost-effectiveness of universal newborn hearing screening...
- Choosing between measures: comparison of EQ-5D, HUI2 and HUI3 in persons with hearing complaintsJanneke P C Grutters
Department of Clinical Epidemiology and Medical Technology Assessment, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
Qual Life Res 16:1439-49. 2007..To generate insight into the differences between utility measures EuroQol 5D (EQ-5D), Health Utilities Index Mark II (HUI2) and Mark III (HUI3) and their impact on the incremental cost-effectiveness ratio (ICER) for hearing aid fitting..
- Societal effects of hearing aid fitting among the moderately hearing impairedManuela A Joore
Department of Clinical Epidemiology and Medical Technology Assessment CEMTA, University Hospital Maastricht, Maastricht, The Netherlands
Int J Audiol 42:152-60. 2003..No effects of hearing aid fitting on generic quality of life could be determined with the EuroQol, while hearing aid fitting did lead to an improvement in one aspect of generic quality of life; namely social functioning...
- An analysis of the costs of implementing the National Newborn Hearing Screening Programme in EnglandK Uus
Audiology and Deafness Group, School of Psychological Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
J Med Screen 13:14-9. 2006..A comparison of costs and outcomes associated with NHSP and IDTS was conducted...
- GJB2 and hearing impairment: promoter defects do not explain the excess of monoallelic mutationsA Pollak
J Med Genet 45:607-8. 2008
- Universal newborn hearing screening: summary of evidenceD C Thompson
Harborview Injury Prevention and Research Center, 325 Ninth Ave, Box 359960, Seattle, WA 98104, USA
JAMA 286:2000-10. 2001..Universal newborn hearing screening (UNHS) has been proposed as a means to speed diagnosis and treatment and thereby improve language outcomes in these children...
- Application of physiological genomics to the study of hearing disordersStefan Heller
Department of Otolaryngology and Program in Neuroscience, Harvard Medical School, Boston, MA, USA
J Physiol 543:3-12. 2002..Finally, it discusses how the use of applied genomic tools, such as gene arrays, will further advance our knowledge of how the inner ear works, develops, ages and regenerates...
- The newborn hearing screening programme in EnglandAdrian Davis
Medical Research Council, Institute of Hearing Research, University of Nottingham, Nottingham NG7 2RD, UK
Int J Pediatr Otorhinolaryngol 67:S193-6. 2003..The aims, protocols, training programme and evaluation of the NHS Newborn Hearing Screening Programme are presented with a view to highlighting the research needed to improve specification of large scale screening programmes...
- Effect of hearing impairment on educational outcomes and employment up to the age of 25 years in northern FinlandM R Jarvelin
Department of Public Health Science and General Practice, University of Oulu, Finland
Br J Audiol 31:165-75. 1997..Hearing impairment appears to have effects on both the outcome of education and employment status...
- Spectrum of hearing disorders and their management in children with CHARGE syndromeSusan Arndt
Department of Oto Rhino Laryngology, Head and Neck Surgery, University Medical Center Freiburg, Freiburg, Germany
Otol Neurotol 31:67-73. 2010..The aim of this study is to explore the feasibility and procedure of cochlear implantation in patients with CHARGE syndrome and to assess the outcome...
- Connexin26 mutations associated with nonsyndromic hearing lossH J Park
Department of Otolaryngology, Ajou University School of Medicine, Suwon, Korea
Laryngoscope 110:1535-8. 2000..The present study investigated the mutations of connexin26 (Cx26) found in patients with nonsyndromic hearing loss (NSHL) and newborns in the Korean population...
- Auditory brainstem response in premature and full-term childrenPricila Sleifer
Hospital de Clinicas de Porto Alegre, Department of Othorhinolaringology, Av Lavras 584 apto 302, 90000000 Porto Alegre, Rio Grande do Sul, Brazil
Int J Pediatr Otorhinolaryngol 71:1449-56. 2007..To compare the absolute latencies of peaks I, III and V and interpeak intervals of premature and full-term children...
- The effects of single and dual sensory loss on symptoms of depression in the elderlyMichele E Capella-McDonnall
Rehabilitation Research and Training Center on Blindness and Low Vision, Mississippi State University, Starkville, MS 39762, USA
Int J Geriatr Psychiatry 20:855-61. 2005....
- Auditory temporal processing deficits in patients with insular strokeD E Bamiou
Neuro Otology Department, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Neurology 67:614-9. 2006..To assess central auditory function in a series of patients with stroke of the insula and adjacent areas...
- Reorganization of the adult auditory system: perceptual and physiological evidence from monaural fitting of hearing aidsKevin J Munro
School of Psychological Sciences, University of Manchester, United Kingdom
Trends Amplif 12:254-71. 2008....
- [Peripheral hearing disorders in childhood. Results of an evidenced based consensus conference]E Seifert
Abt Phoniatrie der Universitäts HNO Klinik, Inselspital, Bern
HNO 53:376-82. 2005
- United Kingdom school-entry hearing screening: current practiceK Bristow
Institute of Health and Society, Fourth Floor, William Leech Building Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Arch Dis Child 93:232-5. 2008....
- Brainstem auditory function at term in preterm babies with and without perinatal complicationsZe D Jiang
Children s Hospital, Fudan University, Shanghai, China
Pediatr Res 58:1164-9. 2005..We conclude that preterm babies with perinatal complications are at high risk of central auditory impairment...
- Identification of neonatal hearing impairment: characteristics of infants in the neonatal intensive care unit and well-baby nurseryB R Vohr
Multicenter Consortium on Neonatal Hearing Screening, Seattle, Washington, USA
Ear Hear 21:373-82. 2000....
- A comparison of screening methods in school-aged childrenWesley W O Krueger
Otology Group San Antonio, 9150 Huebner Road, Suite 160, San Antonio, TX 78240, USA
Otolaryngol Head Neck Surg 127:516-9. 2002..We sought to compare the findings of 3 different hearing screening methods in school-aged children...
- Universal newborn screening for permanent childhood hearing impairment: an 8-year follow-up of a controlled trialColin Kennedy
Department of Child Health, University of Southampton, Southampton, UK
Lancet 366:660-2. 2005..UNS leads to early referral of PCHI...
- Turner's syndrome and hearing disorders in women aged 16-34M Hultcrantz
Department of Otorhinolaryngology, Karolinska Hospital, Stockholm, Sweden
Hear Res 103:69-74. 1997..The data emphasize the importance of early audiological evaluation and information about predisposition to hearing impairment in Turner's syndrome...
- Comparing the clinical effectiveness of different new-born hearing screening strategies. A decision analysisEva Grill
Department of Physical Medicine and Rehabilitation, University of Munich, Munich, Germany
BMC Public Health 5:12. 2005..The objective was to systematically compare two screening strategies for the early detection of new-born hearing disorders, UNHS and risk factor screening, with no systematic screening regarding their influence on early diagnosis.
- German registry for hearing loss in children: results after 4 yearsU Finckh-Krämer
Department of Audiology and Phoniatrics, Benjamin Franklin Medical School, Freie Universitat Berlin, D 14195 62, Berlin, Fabeckstrasse, Germany
Int J Pediatr Otorhinolaryngol 56:113-27. 2000..A minimum standard for patient history was established by the primary examination report. Thus, an important contribution has been made to the prevention of avoidable secondary damage...
- [Universal hearing screening for babies--recommendations for the organization and performance of the universal screening of babies for hereditary hearing disorders in Germany]M Gross
Universitätsklinik für Kinder und Jugendmedizin, Ulm Donau
Z Geburtshilfe Neonatol 208:239-45. 2004
- [Automated hearing threshold estimation in newborns using extrapolated DPOAE input/output functions]T Janssen
Hals Nasen Ohren Klinik, Technischen Universitat Munchen, Klinik rechts der Isar, Munich
HNO 51:971-80. 2003..A new method for automatically assessing hearing loss by means of extrapolated DPOAE I/O-functions was applied for the first time in newborns...
- Effectiveness of a TEOAE-based screening program. Can a patient-tracking system effectively be organized using modern information technology and central data management?W Delb
Department of Otorhinolaryngology and Head and Neck Surgery, University of Saarland, Kirrbergerstr, 66421 Homburg Saar, Germany
Eur Arch Otorhinolaryngol 261:191-6. 2004..A follow-up system as proposed in this paper can also be implemented in AABR (automated auditory brainstem response)-based programs...
- [The parents' opinions on screening program regarding newborn hearing]Peng Jun Zhao
Shanghai Children s Medical Center, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China
Zhonghua Liu Xing Bing Xue Za Zhi 24:608-10. 2003..To investigate opinions on screening of newborn hearing from parent's and its influence to parents and their families...
- The words-in-noise (WIN) test with multitalker babble and speech-spectrum noise maskersMichael J Metz
J Am Acad Audiol 18:718; author reply 718-9. 2007
- Newborn hearing screening by transient evoked otoacoustic emissions: analysis of response as a function of risk factorsB De Capua
Department of Otorhinolaryngology, University of Siena, Italy
Acta Otorhinolaryngol Ital 23:16-20. 2003..These data stress the importance of the risk factors for hearing loss, including prolonged assisted ventilation, ototoxic drugs, and severe birth asphyxia...
- Ultra-fast quantification of hearing loss by neural synchronization stabilities of auditory evoked brainstem activityFarah I Corona-Strauss
Center for Research in Communication Dis orders, Saarland University Hospital, Homburg Saar, Germany
Conf Proc IEEE Eng Med Biol Soc 2007:2476-9. 2007..It is concluded that the proposed feature following the novelty detection paradigm might be used for the ultra-fast detection of hearing thresholds and is thus ideally suited for the use in efficient universal hearing screening programs...
- Clinical observations with evoked otoacoustic emissions at Mayo ClinicMartin S Robinette
Mayo Arrowhead, 20199 N 75th Avenue, Glendale, AZ 85308, USA
J Am Acad Audiol 14:213-24. 2003..Finally, our experience with TEOAEs in newborn hearing screening is described...
- Universal newborn hearing screening: a question of evidenceA Durieux-Smith
Faculty of Health Sciences, University of Ottawa, Canada
Int J Audiol 47:1-10. 2008..It is argued that early access to hearing should be the desired primary outcome of NHS. The numerous studies demonstrating improved ages of diagnosis resulting from NHS programs constitute adequate evidence to support these initiatives...
- Measuring of distortion product otoacoustic emissions using multiple tone pairsIoannis Kastanioudakis
Ear, Nose and Throat Department, School of Medicine, University of Ioannina, P O Box 1186, 451 10 Ioannina, Greece
Eur Arch Otorhinolaryngol 260:395-400. 2003..The mean examination time in both groups (NH and SNHL) was shorter with the Sim method. Therefore, the multiple-tone pairs stimulation method seems to be more suitable when it is used as an auditory screening test...
- [Fundamentals of hearing screening in neonates (standard of care)]Martin Ptok
Klinik für Phoniatrie und Pädaudiologie, Hannover
Z Geburtshilfe Neonatol 207:194-6. 2003
- Neonatal hearing screening: a combined click evoked and tone burst otoacoustic emission approachVicky W Zhang
Centre for Communication Disorders, The University of Hong Kong, Hong Kong SAR, China
Int J Pediatr Otorhinolaryngol 72:351-60. 2008..This study evaluated an alternative transient evoked otoacoustic emissions method for screening hearing in newborn babies that may reduce the referral rate of initial screening...
- The effect of mobile phone to audiologic systemVirachai Kerekhanjanarong
Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
J Med Assoc Thai 88:S231-4. 2005..When the authors focused on the 8 subjects that used the mobile phone more than 60 mins per day. It indicated that the hearing threshold of the dominant ears was worse than the nondominant ears...
- Auditory assessment of alcoholics in abstinenceSandra Beatriz Afonso Ribeiro
Communications Disorders, Universidade Tuiuti do Paraná
Braz J Otorhinolaryngol 73:452-62. 2007..Alcoholism is considered the most relevant addiction in the international arena and few investigations have examined the association between sensorineural hearing loss and alcohol abuse, with conflicting results...
- Click-evoked otoacoustic emissions (CEOAEs) recorded from neonates under 13 hours old using conventional and maximum length sequence (MLS) stimulationJessica de Boer
MRC Institute of Hearing Research, Southampton Outstation, Royal South Hants Hospital, Brintons Terrace, Mailpoint OAU, Southampton, Hampshire SO14 OYG, UK
Hear Res 233:86-96. 2007..The findings show that MLS averaging can reduce false alarm rates by up to 15% in very young neonates in a neonatal ward setting...
- Pediatric audiology: a reviewRyan B Gregg
Feeding and Swallowing Services, Children s Hospital of Wisconsin, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
Pediatr Rev 25:224-34. 2004
- Classification of technical pitfalls in objective universal hearing screening by otoacoustic emissions, using an ARMA model of the stimulus waveform and bootstrap cross-validationE Vannier
CETP, 10 12 avenue de l Europe, 78140 Vélizy, France
Med Eng Phys 27:669-77. 2005..We therefore suggest that new parameters and methodology based upon a more thorough analysis of SWs can improve the efficiency of TEOAE-based tests by helping the most frequent technical pitfalls to be identified...
- The effect of the number of averaged responses on the measurement of transiently evoked otoacoustic emissions in newbornsStavros G Korres
ENT Department of Athens National University, Hippokration Hospital, 114 Vas Sofias Av, GR 11528 Athens, Greece
Int J Pediatr Otorhinolaryngol 70:429-33. 2006..The aim of this study was to examine the effect of the number of averaged responses on the measurement of transiently evoked otoacoustic emissions (TEOAEs)...
- Hearing screening of infants in Neonatal Unit, Hospital Universiti Sains Malaysia using transient evoked otoacoustic emissionsM D Mohd Khairi
Department of Otorhinolaryngology Head and Neck Surgery, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia
J Laryngol Otol 119:678-83. 2005..In conclusion, hearing screening in high-risk neonates revealed a total of 1 per cent with hearing loss. The changes in the risk profile indicate improved perinatal handling in a neonatal population at risk for hearing disorders.
- [Screening project of identification of hearing deficits in newborns]Troels Reinholdt Møller
Arhus Universitetshospital, Arhus Sygehus, Audiologisk afdeling, Arhus C
Ugeskr Laeger 169:900-3. 2007..During the first year of screening, 6154 children have been tested and 12 newborns with hearing deficits have been identified...
- [Neonatal hearing screening during the first and second day of life]Z G Del Buono
Unità di Neonatologiaù, Casa di Cura Santa Maria, Bari, Italy
Minerva Pediatr 57:167-72. 2005..The identification of hearing loss through neonatal and infant life can prevent or reduce many of these adverse consequences, permitting early intervention...
- Hearing threshold assessment post grommet insertion. Is it reliable?H Griffiths
Department of ENT, Russells Hall Hospital, Dudley, UK
J Laryngol Otol 121:431-4. 2007..We conclude that there is evidence that ABR can be inaccurate after grommet insertion, overestimating hearing thresholds. We believe that the mechanism by which the error is realised is temporary threshold shift...
- [The most frequent ear problems in general practice. Can you see that your patient is hard-of-hearing?]Judith Neumaier
MMW Fortschr Med 148:4-6. 2006
- Exposure to occupational noise: otoacoustic emissions test alterationsFrederico Prudente Marques
Hospital CEMEP, Department of Social and Preventive Medicine, and School of Public Health, University of Sao Paulo, Brazil
Braz J Otorhinolaryngol 72:362-6. 2006..Exposure to occupational noise may cause injuries to the inner ear, and the distortion product otoacoustic emissions (DPOAE) may identify initial auditory alterations, thus assisting NIHL early diagnosis...
- Effects of maturation on parameters used for pass/fail criteria in neonatal hearing screening programmes using evoked otoacoustic emissionsMaziar Sadri
MRC Institute of Hearing Research, Southampton University Hospitals Trust, Southampton, UK
Audiol Neurootol 12:226-33. 2007..This leads to the consideration of whether the establishment of age-dependent pass/fail criteria could reduce the false alarm rate and the subsequent strain on diagnostic centres...
- Sacculo-collic pathway dysfunction accompanying auditory neuropathyKianoush Sheykholeslami
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Acta Otolaryngol 125:786-91. 2005..Information such as that provided in this report will be valuable for clinicians caring for this group of patients...
- Aided loudness growth and satisfaction with everyday loudness perception in compression hearing aid usersLu Feng Shi
Department of Communication Sciences and Disorders, Syracuse University, Syracuse, New York 13244, USA
J Am Acad Audiol 18:206-19. 2007..Most listeners were satisfied with their perception of soft, average, and loud environmental sounds, regardless of how well or not well their WDRC aids normalized their aided loudness growth...
- [Effects of intrauterine hypotrophy and perinatal hypoxia on cochlear function evaluated by click evoked otoacoustic emissions (TEOAE)]Natalia Urbaniec
II Klinika i Katedra Sl AM w Zabrzu
Otolaryngol Pol 58:365-72. 2004..Co-existing factors such as intrauterine hypotrophy and perinatal hypoxia affect the cochlear function significantly deeper than each of them working separately...
- Otoacoustic emissions: a new method for newborn hearing screeningP Saurini
Department of Otolaryngology, Audiology and Phoniatrics G Ferreri La Sapienza University of Rome Italy
Eur Rev Med Pharmacol Sci 8:129-33. 2004..The newborn hearing screening is being accepted, at a faster growing pace, by an increasing number of health systems in the whole world...
- [Systematic hearing screening for newborns in the Champagne-Ardennes region: 32,500 births in 2 years of experience]P Schmidt
Service ORL et chirurgie cervicofaciale, Hopital Robert Debre, Centre Hospitalier Universitaire de Reims, 51092 Reims Cedex, France
Ann Otolaryngol Chir Cervicofac 124:157-65. 2007..To report a Universal Newborn Hearing Screening (UNHS) program developed in the Champagne-Ardennes region in 2004-2005...
- Prospective noise induced changes to hearing among construction industry apprenticesN S Seixas
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
Occup Environ Med 62:309-17. 2005..To characterise the development of noise induced damage to hearing...
- Otoacoustic emissions latency difference between full-term and preterm neonatesW Wiktor Jedrzejczak
Institute of Physiology and Pathology of Hearing, ul Zgrupowania AK Kampinos 1, 01 943 Warsaw, Poland
Hear Res 231:54-62. 2007..The correspondence, which was found between frequencies of long-duration components and the spectral peaks of spontaneous otoacoustic emissions (SOAEs), suggests that those components may be connected with SOAEs...
- [Principles of hearing aids]O Thiede
Klinik und Poliklinik Fur Hals, Nasen und Ohrenheilkunde des Universitätsklinikums
Laryngorhinootologie 84:357-70; quiz 371-4. 2005..Especially the possibilities of the treatment of uni- and bilateral hearing impairment are discussed. The principles of the actual hearing aids technology are described to support the Otolaryngologist in his consultation...
- [Notched-noise-BERA: methods and diagnostic use]R Schönweiler
Abteilung für Phoniatrie und Pädaudiologie in der Klinik für HNO Heilkunde, Universitatsklinikum Schleswig Holstein, Campus Lubeck
Laryngorhinootologie 86:336-44. 2007..Currently, new technologies like auditory steady-state responses and Chirp-evoked potentials promise to overcome some disadvantages of the NN-BERA...
- Using genetic algorithms with subjective input from human subjects: implications for fitting hearing aids and cochlear implantsDeniz Baskent
Starkey Hearing Research Center, Berkeley, California 94704, USA
Ear Hear 28:370-80. 2007....
- An alternative strategy for universal infant hearing screening in tertiary hospitals with a high delivery rate, within a developing country, using transient evoked oto-acoustic emissions and brainstem evoked response audiometryN N Mathur
Department of ENT and Head Neck Surgery, Lady Hardinge Medical College and associated Smt Sucheta Kriplani Hospital and Kalawati Saran Children s Hospital, New Delhi, India
J Laryngol Otol 121:639-43. 2007..The system should be able to diagnose, in a timely fashion, all infants with severe and profound hearing losses...
- The effect of stimulus rate and time-separation on Volterra slices of otoacoustic emissionsBen Lineton
MRC Institute of Hearing Research, Royal South Hants Hospital, Southampton, SO14 OYG, United Kingdom
Hear Res 239:34-53. 2008..In addition, measured cross-correlations between waveforms of VS of different order and slice number were obtained, revealing a complex dependence on time-separation that has not been explained...
- Infant hearing screening: effects of timelineP W Y Tsui
Centre for Communication Disorders and Division of Speech and Hearing Sciences, Faculty of Education, University of Hong Kong, Hong Kong, China
Clin Otolaryngol 33:108-12. 2008..The current study investigates the effects of age and time interval between tests on hearing assessment results...
- Effects of single-channel phonemic compression schemes on the understanding of speech by hearing-impaired listenersA Goedegebure
Department of Audiology--ENT, Erasmus Medical University Centre Rotterdam, The Netherlands
Audiology 40:10-25. 2001..In background noise, consistently negative effects of speech processing were found. The combined use of phonemic compression and USOM compensation is promising in conditions without background noise...
- Recent outcome of tympanoplasty in the elderlyT Saito
Department of Otolaryngology, Fukui Medical University, Japan
Otol Neurotol 22:153-7. 2001..CONCLUSIONS: There is no contraindication for tympanoplasty in older patients if their physical status is the same or better than what is normal for their chronological age...
- [Early detection of hearing impairment in newborns using automatic otoacoustic emission in Virovitica County Hospital Maternity Ward]Jadranko Segregur
Odjel za zenske bolesti i porodnistvo Opće bolnice Virovitica
Lijec Vjesn 130:55-7. 2008..To investigate the prevalence of hearing impairment in newborns and its successful early detection using automatic otoacoustic emission (A-OAE)...
- Otoacoustic emissions and auditory assessment in infants at risk for early brain damageJ Vatovec
University Department of Otorhinolaryngology and Cervicofacial Surgery, Clinical Center, 1525 Zaloska 2, Ljubljana, Slovenia
Int J Pediatr Otorhinolaryngol 58:139-45. 2001..Recording of evoked otoacoustic emissions is very helpful in pediatric audiometry, but any interpretation of the results should consider the possibility of auditory neuropathy...
- The effects of aging on distortion-product otoacoustic emissions in adults with normal hearingYasue Uchida
Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Morioka, Aichi, Japan
Ear Hear 29:176-84. 2008..Therefore, in selecting subjects, we applied the stringent criterion in pure-tone thresholds (PTT) to limit dispersion among normal-hearing thresholds...
- An objective measure for selecting microphone modes in OMNI/DIR hearing aid circuitsKen W Grant
Army Audiology and Speech Center, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
Ear Hear 29:199-213. 2008..In addition, data are shown regarding how a decision to choose one microphone mode over another might change as a function of speech to noise ratio (SNR) and spatial orientation of the listener...
- A universal newborn hearing screening program in TaiwanHung Ching Lin
Department of Otolaryngology, Mackay Memorial Hospital, No 92, Chung Shan N Road, Sec 2, 104, Taipei, Taiwan
Int J Pediatr Otorhinolaryngol 63:209-18. 2002..Our objective was to assess the feasibility, accuracy and cost effectiveness of implementing universal newborn hearing screening in Taiwan...
- Six year effectiveness of a population based two tier infant hearing screening programmeS A Russ
Centre for Community Child Health, Royal Children s Hospital, Melbourne, Australia
Arch Dis Child 86:245-50. 2002....
- Newborn hearing screening: the relation between bathing and the retesting rateTatiana Redeschi Marques
Universidade Tuiuti, Parana, Brazil
Braz J Otorhinolaryngol 74:375-81. 2008..One of the goals of a Newborn Hearing Screening Program (NHSP) is to have a low retesting rate...
- Neonatal hearing screening with otoacoustic emissions: an evaluationK Daemers
E.N.T. Department, Sint-Augustinus Medical Institute (U.I.A, Antwerp, Belgium
Acta Otorhinolaryngol Belg 50:203-9. 1996..The practical problems of the screening program and especially the importance of a stringent follow-up procedure in case of failure, are discussed...
- [Evaluation and analysis of impulse noise and study of its influence on hearing organ using otoacoustic emissions]Wiesław Konopka
Klinika Otolaryngologiczna Instytutu Chirurgii WAM w Łodzi
Otolaryngol Pol 56:515-7. 2002
- Cochlear dysfunction in patients with mitochondrial myopathyStavros Korres
ENT Clinic of Athens National University, Ippokration Hospital, 23 Achaion Street, Agia Paraskevi, GR 18536 Athens, Greece
ORL J Otorhinolaryngol Relat Spec 64:315-20. 2002..Otoacoustic emissions might provide a useful tool in the clinical work-up and follow-up of these patients...
- Evaluation of cochlear hearing disorders: normative distortion product otoacoustic emission measurementsDavid M Mills
University of Washington, Seattle, Washington 98195 7923, USA
Ear Hear 28:778-92. 2007..This protocol, designed to distinguish among different cochlear hearing disorders, has been tested to date only through lesion studies in the gerbil (Mills, Ear and Hearing, 27, 508-525, ..
- Occupational exposure to noise decreases otoacoustic emission efferent suppressionMariola Sliwinska-Kowalska
Department of Physical Hazards, Nofer Institute of Occupational Medicine, Lodz, Poland
Int J Audiol 41:113-9. 2002..The results of the study suggest that OAEs, particularly DPOAE contralateral suppression, are likely to become a valuable method for assessing early hearing damage caused by exposure to noise...
- Factors affecting the benefits of high-frequency amplificationAmy R Horwitz
Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, 135 Rutledge Avenue, MSC 550, Charleston, SC 29425 5500, USA
J Speech Lang Hear Res 51:798-813. 2008..This study was designed to determine the extent to which high-frequency amplification helped or hindered speech recognition as a function of hearing loss, gain-frequency response, and background noise...
- Modeling relationships between various domains of hearing aid provisionHartmut Meister
ENT Hospital, University of Cologne, Cologne, Germany
Audiol Neurootol 8:153-65. 2003..Moreover, the models help to predict the outcome of clinically used inventories (i.e. the Glasgow Hearing Aid Benefit Profile)...
- Screening for handicapping hearing loss in the elderlyGeorge A Gates
Department of Otolaryngology Head and Neck Surgery, University of Washington School of Medicine, Seattle, WA 98195 7923, USA
J Fam Pract 52:56-62. 2003..To compare 2 screening methods for unrecognized handicapping hearing loss in the elderly...
- Audiologic assessment of children with suspected hearing lossKaren C Johnson
Children s Auditory Research and Evaluation Center, House Ear Institute, 2100 West Third Street, Fifth Floor, Los Angeles, CA 90057, USA
Otolaryngol Clin North Am 35:711-32. 2002..Failure to do so is likely to result in inaccurate or incomplete delineation of auditory function...
- "Linear" and "derived" otoacoustic emissions in newborns: a comparative studyG Tognola
CNR Centre of Biomedical Engineering, Polytechnic of Milan, Italy
Ear Hear 22:182-90. 2001..Therefore, screening criteria based on the evaluation of the SNR (or similar parameters) could be influenced by the type of averaging used during the acquisition...
- Comparison of two methods of TEOAE recording in newborn hearing screeningFerdinando Grandori
Istituto di Ingegneria Biomedica CNR, Milan, Italy
Int J Audiol 41:267-70. 2002..6 times faster than the ILO88, bearing in mind, however, that when using ILO88, the end of the recording is decided by the operator on the basis of some mandatory decision rules...
- Long-term results and experience with the first-generation semi-implantable electromagnetic hearing aid with ossicular replacement device for mixed hearing lossPer Caye-Thomasen
Department of Otorhinolaryngology, Head and Neck Surgery, Gentofte University Hospital of Copenhagen, Hellerup, Denmark
Otol Neurotol 23:904-11. 2002..The short-term results have previously been published as excellent in both surgical and audiologic terms. To analyze and discuss reasons of treatment failure, as well as future perspectives...
- Gender differences among newborns on a transient otoacoustic emissions test for hearingJ W Cassidy
Louisiana State University, USA
J Music Ther 38:28-35. 2001..6 kHz, most sensitive hearing recorded at 3.2 kHz). A significant two-way interaction indicated that differences in hearing sensitivity between genders increased as the frequency increased...
- Evaluation of the progress of therapy in patients with cleft lip, jaw and palate, using voice analysis--a pilot studyChristiane Gugsch
Independent Orthodontic Department, Center of Stomatology, University of Leipzig, Leipzig, Germany
J Orofac Orthop 69:257-67. 2008..the hard and soft palate in patients with cleft lip, jaw and/or palate in conjunction with speech, voice and hearing disorders can considerably restrict the ability to communicate...
- An introduction to the genetics of normal and defective hearingA Martini
Servizio di Audiologia, Clinica ORL dell Università di Ferrara, Italy
Ann N Y Acad Sci 830:361-74. 1997..provide an important resource for rapid identification of cochlear genes involved in normal hearing and hearing disorders. Studies of the molecular genetics of the inner ear are hampered by the relative inaccessibility of the ..
- Bilateral sensorineural hearing disorders in children: etiology of deafness and evaluation of hearing testsC Walch
ENT Hospital, University of Graz, Auenbruggerplatz 20, A 8036, Graz, Austria
Int J Pediatr Otorhinolaryngol 53:31-8. 2000The purpose of this study was to determine the etiology of bilateral sensorineural hearing disorders in children and to evaluate the performed hearing tests by comparison of the results of the objective and subjective tests.
- Estrogen Modulation of Auditory ProcessingRaphael Pinaud; Fiscal Year: 2012..b>Hearing disorders and lower auditory processing efficiency also occur in women with Turner's syndrome, who are deficient ..
- WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTIONDouglas H Keefe; Fiscal Year: 2013..More accurate diagnoses would improve follow-up clinical care provided to infants with hearing disorders. Aim 2 evaluates whether middle-ear problems detected by the WB test battery in NHS can predict continued ..
- Structure-function analyses on novel processes of type II vestibular hair cellsJennifer S Stone; Fiscal Year: 2013..Studies of damaged vestibular organs will help uncover the relationship between normal and regenerated hair cells with processes and the potential of regenerated hair cells to restore function in balance and hearing disorders.
- Cloning &Functional Studies of Deafness MutationsKenneth R Johnson; Fiscal Year: 2013DESCRIPTION (provided by applicant): The mouse is an excellent model for studying human hearing disorders because of the similarities in inner ear anatomy, function, and pathology...
- The Effect Of Deafness Associated Mutations on MyosinVIIA FunctionEva Forgacs; Fiscal Year: 2010..by deafness, vestibular dysfunction and blindness (retinitis pigmentosa), and two autosomal recessive hearing disorders, DFNA11 and DFNB2 in humans, and the shaker-1 phenotype in mice...
- Genetics of Age-Related Hearing LossKenneth R Johnson; Fiscal Year: 2013..Mice and humans often share the same genes and inner ear pathologies underlying monogenic hearing disorders, so genetic studies of AHL in mice are likely to add significantly to our understanding of human presbycusis...
- The role of cochlear pericytes in control of cochlear microcirculationXiao Rui Shi; Fiscal Year: 2009..A reduction of cochlear blood flow is involved in a number of hearing disorders. Pericytes, surrounding blood microvessels, play important roles for many organs in the regulation of ..
- Regeneration and reinnervation of mechanosensory hair cellsDavid J Kozlowski; Fiscal Year: 2013..Currently, more than 800,000 veterans are receiving disability compensation for service-connected hearing disorders, which is expected to grow by 18% a year with payments totaling $1.1 billion annually by 2011...
- Presynaptic GABA-A receptor activation in auditory brainstem axon terminalsCATHERINE JEANNE CHALENSKI WEISZ; Fiscal Year: 2013..A full understanding of the complexity of the perception of sound will guide refined therapies for treatment of hearing disorders.
- Perivascular macrophages endothelial interactions at the blood labyrinth barrierXiao Rui Shi; Fiscal Year: 2013..Disruption of the BLB has long been considered a major etiologic factor in a variety of hearing disorders, including autoimmune inner ear disease, Meniere's disease, meningitis-associated labyrinthitis, and ..
- A role for diaphanous homolog 3 in the auditory systemCYNTHIA JANE SCHOEN; Fiscal Year: 2011DESCRIPTION (provided by applicant): Hearing disorders account for the majority of sensory deficit disorders in the United States and affect 1 in 2000 births...
- Hearing circadian rhythms.Barbara Canlon; Fiscal Year: 2013..These studies are of clinical importance since noise-induced hearing disorders are an important public health issue and are exponentially increasing in the human population...
- FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEXChristoph E Schreiner; Fiscal Year: 2013..Examples of central auditory consequences of peripheral hearing disorders are a reduction of speech comprehension for patients even if they that have well-fitted hearing aids, or the ..
- Anatomical and Functional Properties of Auditory Nerve SynapsesMARIA EULALIA RUBIO; Fiscal Year: 2013..results of our studies can be applied to efforts to optimize strategies for treating hearing loss and other hearing disorders. A large body of evidence indicates that the auditory system is highly specialized...
- Fibrovascular coupling in the cochlea and pericyte recruitment after noiseXiao Rui Shi; Fiscal Year: 2013..reduction of cochlear blood flow and disruption of blood-labyrinth barrier (BLB) involved in a number of hearing disorders. Development of new treatments for vascular-related hearing loss requires a better understanding of control ..
- The role of short-term plasticity at the calyx of Held for auditory processingYunxiang Chu; Fiscal Year: 2013..of hearing in the auditory brainstem will allow for a better understanding of the etiology of human hearing disorders. The long-term objectives of the proposed research are to define the mechanisms that govern short-term ..
- Development of a laser holography otoscope for diagnosis in the clinicJohn J Rosowski; Fiscal Year: 2010..Our fundamental hypothesis is that both (a) the pre-surgical diagnosis of conductive-hearing disorders with intact TM and (b) the evaluation of causes of surgical failure in ossicular and TM reconstructions can ..
- Regulation of Inner Ear Stem CellsALAN GI LUN CHENG; Fiscal Year: 2013..My longstanding interest in treating hearing disorders and, in parallel, performing basic science research on the same topic has fueled my decision to become a ..
- Cellular regulation of cochlear blood flowA PHILINE WANGEMANN; Fiscal Year: 2012..It is of clinical importance to understand the mechanisms that regulate cochlear blood flow, since many hearing disorders, such as sensorineural hearing loss, acute acoustic trauma, noise-induced hearing loss, tinnitus, Meniere&..
- EphB signaling in deafferentation-induced auditory brainstem plasticity.PAUL ALAN NAKAMURA; Fiscal Year: 2012..More specifically, it may provide beneficial insights into therapies for congenital hearing disorders by uncovering mechanisms of neural reorganization and plasticity during development...
- 2010 Auditory System Gordon Research Conference and Gordon Research SeminarLisa V Goodrich; Fiscal Year: 2010..and function of the auditory system will improve the diagnosis and treatment of this wide array of hearing disorders. The central goal of The Auditory System GRC is to share the newest findings that explain how acoustic ..
- Multi-site study of speech perception training for hearing-aid usersCharles S Watson; Fiscal Year: 2013..To test this hypothesis, extended speech perception training of hearing aid users will be undertaken for the first time, at each of six major centers for research and treatment of hearing disorders.
- Multi-site study of speech perception training for hearing-aid usersCharles S Watson; Fiscal Year: 2010..To test this hypothesis, extended speech perception training of hearing aid users will be undertaken for the first time, at each of six major centers for research and treatment of hearing disorders.
- Experimental - Theoretical Studies of Cochlear MechanismsDennis M Freeman; Fiscal Year: 2013..genetically modified mice will provide a framework for understanding the physical basis of the corresponding hearing disorders. Aim 3: We propose to measure interactions of the TM with other cochlear structures in an isolated, intact ..
- UNMC SIG Supporting Next-generation DNA Sequencing TechnologyJames Eudy; Fiscal Year: 2010....
- Neurophysiology and Anatomy of Multisensory ProcessingCharles E Schroeder; Fiscal Year: 2013..these elements, will enhance our mechanistic understanding of perceptual/cognitive impairment specific to hearing disorders, and in a spectrum of disorders including ADHD, autism and schizophrenia, where defects in normal ..
- Genome-wide Study of Hearing ImpairmentThomas Hoffmann; Fiscal Year: 2013..Although there have been some studies on the genetics of age-related hearing disorders, they have been on limited sample sizes and have not fully explained the heritability of the disease...
- CORTICAL REPRESENTATION OF AUDITORY SPACEJohn C Middlebrooks; Fiscal Year: 2012..This will aid in diagnosis and treatment of spatial hearing disorders. Aims 2 and 3 will isolate and quantify the contribution of specific low- and high-frequency spatial cues to ..
- Efferent inhibitory mechanisms in binaural processingR Michael Burger; Fiscal Year: 2013..The findings of the proposed studies could have direct implications for a number of hearing disorders, in particular, profoundly deaf patients whose treatment includes bilateral auditory prostheses...
- Synergistic in vivo and in vitro approaches in the MSONace L Golding; Fiscal Year: 2012..An understanding of how binaural cues are processed by the brain is thus a prerequisite for the development of effective solutions for deafness and other hearing disorders.
- Role of the inferior colliculus and superior olivary complex in the development aWalid Jalabi; Fiscal Year: 2013..We expect that insights gained from these models will inform us as to how disruptions of auditory neuron development can contribute to human hearing disorders.
- Support cell specific expression of regulatable Math-1David Poulsen; Fiscal Year: 2006..The lack of effective treatments for hair cell loss and many other forms of acquired and inherited hearing disorders has prompted interest in the potential application of gene transfer techniques to restore normal cochlear ..
- Transduction of the Mouse Auditory System with AAVDIANA LURIE; Fiscal Year: 2003..The lack of effective treatment for many forms of acquired and inherited hearing disorders has prompted interest in the potential application of newly developed gene delivery techniques to restore ..
- Telephone screening test for hearing using three-digit sequences in noise.Charles Watson; Fiscal Year: 2009..Successful development and implementation of such a test has the potential to greatly increase awareness of hearing disorders and the numbers of persons with hearing impairment who seek services...
- The Mouse as an Instrument for Ear Research VKenneth R Johnson; Fiscal Year: 2012..Promoting the responsible use of appropriate models is critical to the development of effective new therapeutic approaches to treating human hearing disorders.
- IMPROVED STEROID THERAPY FOR HEARING LOSSDennis Trune; Fiscal Year: 2000..In fact, prednisone therapy is recommended for various sudden and idiopathic hearing disorders for which there is no implication of underlying immune problems...
- The 8th Conference on the Molecular Biology of Hearing &DeafnessAllen F Ryan; Fiscal Year: 2013..4. To promote translational research that can lead to diagnostics and therapeutics for the treatment of hearing disorders. 5...
- Ecological Momentary Assessment in Hearing DisordersJames Henry; Fiscal Year: 2009..It is our hope that this pilot project will provide the basis for future clinical research examining the real-time real-world impact of auditory disorders on everyday life. ..
- Training of Auditory Spectral and Spectro- Temporal Modulation DetectionAndrew T Sabin; Fiscal Year: 2010..is often degraded in normal-hearing listeners in difficult listening environments, and in individuals with hearing disorders. Of interest here is the possibility that the capacity to detect peaks and valleys in a spectral envelope ..
- Jr. Faculty Recruitment into New Auditory Neuroscience CoresJAMES DOUGLAS BOSWELL; Fiscal Year: 2010..HEl provides an ideal environment for the study of hearing disorders, and is striving to fill a need for strengthened research in the CAN core by the recruitment of a ..
- MACROMOLECULAR ARRAYS IN EXTRACELLULAR MATRIX OF COCHLEAVladimir Tsuprun; Fiscal Year: 2003..Structural abnormalities of the matrix may lead to different types of hearing disorders. However, molecular composition and structure of this matrix are not well understood...
- Segregation of Auditory Signals in CortexAlex D Reyes; Fiscal Year: 2013..The data and simulations will shed light on how hearing disorders are manifested at the cellular and network levels and conversely, how dysfunction at the cellular and ..
- HUMAN AUDITORY CORTEX PHYSIOLOGYMatthew Howard; Fiscal Year: 2000..cortex implants have theoretical safety advantages as well as the potential for use in a wider range of hearing disorders. The unifying theme of this proposal is to study the physiologic properties of human auditory cortex using ..
- Studies of cochlear mechanics: otoacoustic emissionsTianying Ren; Fiscal Year: 2005..emission (DPOAE) has been widely used for infant hearing screening, the diagnosis and monitoring of hearing disorders, and for studying hearing mechanisms...
- Comprehensive genomic approach to rare hearing disorders and ataxiaMargit Burmeister; Fiscal Year: 2010..These findings can improve accurate diagnosis, presymptomatic testing, family planning and personalizing treatment. It may also ultimately lead to new treatments. ..
- PHARMACOLOGY OF VESTIBULAR NEUROTRANSMISSIONPaul Guth; Fiscal Year: 2000..Also, while vestibular physiology is of interest in its own right, the process of the vestibular periphery are sufficiently similar to those of a cochlea that knowledge gained may be applied to hearing disorders.
- FUNCTIONAL ORGANIZATION--NONPRIMARY AUDITORY CORTEXJOSEF RAUSCHECKER; Fiscal Year: 2004..the ultimate understanding of the neural basis of speech perception and of a variety of central speech and hearing disorders. The goal of my research is to identify the role different areas in the auditory cortex of the rhesus monkey ..
- ROLES OF ACETYLCHOLINE IN AGE RELATED HEARING DISORDERSKejian Chen; Fiscal Year: 2001Age-related hearing disorders include decreased pure tone perception and poor speech comprehension during background noise...
- CONFERENCE ON MOLECULAR BIOLOGY OF HEARING AND DEAFNESSAllen Ryan; Fiscal Year: 2009..encourage translational research that can lead to diagnostics and therapeutics for the treatment of hearing disorders;and 5) provide outreach to patient advocacy groups and schools in the Boston area, with education on the ..
- Mapping Auditory Brain Function with Mn-Enhanced MRIDANIEL TURNBULL; Fiscal Year: 2005..the basis for future brain mapping investigations in normal and genetically-engineered mice, providing much needed new neuroimaging tools for studying the genetic pathways underlying normal hearing and hearing disorders.
- SOME DETERMINANTS OF SPEECH PERCEPTIONJoanne Miller; Fiscal Year: 2007..firm basis from which to study both the development of speech processing abilities during the first years of life, and those aspects of speech, language, and hearing disorders that involve acoustic-phonetic processing.
- Cross-generational sound change in American EnglishEwa Jacewicz; Fiscal Year: 2009..for the development of clinical instruments for the fair and accurate assessment of both speech language and hearing disorders in various regions (and cultures) of the United States...
- MAPPING DEAFNESS GENES USING GENOMIC MISMATCH SCANNINGVivian Cheung; Fiscal Year: 2002..This will eventually affect the prevention, treatment and care of hearing disorders. Genomic mismatch scanning (GMS) is a high-throughput genetic linkage technique that allows physical ..
- CONTROL OF PROLIFERATION IN COCHLEAR SENSORY EPITHELIAJOHN OBERHOLTZER; Fiscal Year: 2001..observations in animal model systems have suggested that an effective approach to the treatment of those hearing disorders which result from the loss of hair cells might be to stimulate the production of replacements...
- MOUSE MODELS OF THE HUMAN HEARING DISORDER DFNA15Jian Zuo; Fiscal Year: 2003..Thus, this BAC transgenic technology can be widely used for making mouse models of dominant hearing disorders in which the disease genes display complex expression patterns, or in which the mutations are gain-of-..
- GENETICS OF HEARING IMPAIRMENTRobert Ruben; Fiscal Year: 1990..These will include the application of molecular genetics to human hearing disorders; the role of animal models; a critical presentation of syndromic, non-syndromic and polygenic varieties of ..
- SCF Complexes: Key to Understanding Cochlear HomeostasisIsolde Thalmann; Fiscal Year: 2006..Ultimately, the data from this project could provide a foundation for genetic and pharmacologic intervention in hearing disorders.
- MECHANISMS OF AUDITORY DYSFUNCTIONDavid Nelson; Fiscal Year: 2003..will continue to advance our understanding of the characteristics and mechanisms of hearing and hearing dysfunction and will have direct implications for clinical diagnosis and eventual management of hearing disorders.
- Functions of Corticofugal Auditory SystemNobuo Suga; Fiscal Year: 2009..will be able to propose possible neural mechanisms for the reorganization of the auditory system caused by hearing disorders. We will study the response properties of cortical and subcortical auditory neurons, and then study how ..
- AUDITORY ENHANCEMENT AND SUPPRESSIONBEVERLY WRIGHT; Fiscal Year: 1999..Finally, a deeper understanding of enhancement and suppression in normal-hearing listeners may aid in the diagnosis and treatment of hearing disorders, because both effects are much smaller in hearing-impaired listeners.
- Cadherin regulation of tissue polarity and growthMichael Simon; Fiscal Year: 2007..new insights into PCP and growth control as well as into the function of protocadherins, which have been implicated in the Usher Syndrome hearing disorders and as tumor suppressors in liver and colon carcinomas. [unreadable] [unreadable]
- Otitis Media Impact on the Inner EarDennis Trune; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..