Genomes and Genes
Summary: The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications339 found, 100 shown here
- Marked improvement in asthma after Lap-Band surgery for morbid obesityJ B Dixon
Monash University Department of Surgery, Alfred Hospital, Melbourne, Victoria, Australia
Obes Surg 9:385-9. 1999Asthma and morbid obesity are common chronic conditions that may be related. Laparoscopic banding provides effective weight control of morbid obesity...
- Bariatric surgery: a systematic review and meta-analysisHenry Buchwald
Department of Surgery, University of Minnesota, Minneapolis 55455, USA
JAMA 292:1724-37. 2004..About 5% of the US population is morbidly obese. This disease remains largely refractory to diet and drug therapy, but generally responds well to bariatric surgery...
- Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed mealA B Goldfine
Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
J Clin Endocrinol Metab 92:4678-85. 2007..The etiology of the syndrome and metabolic characteristics remain incompletely understood. Recent studies suggest that levels of incretin hormones are increased after GB and may promote excessive beta-cell function and/or growth...
- The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetesFrancesco Rubino
IRCAD European Institute of Telesurgery, University Louis Pasteur, Strasbourg, France
Ann Surg 244:741-9. 2006..We sought to distinguish between these two mechanisms...
- A leptin missense mutation associated with hypogonadism and morbid obesityA Strobel
Nat Genet 18:213-5. 1998
- Maternal morbid obesity and the risk of adverse pregnancy outcomeMarie I Cedergren
Division of Obstetrics and Gynecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
Obstet Gynecol 103:219-24. 2004..To evaluate whether morbidly obese women have an increased risk of pregnancy complications and adverse perinatal outcomes...
- Preoperative nutritional status of patients undergoing Roux-en-Y gastric bypass for morbid obesityLouis Flancbaum
Department of Surgery, St Luke s Roosevelt Hospital Center, New York, NY 11542, USA
J Gastrointest Surg 10:1033-7. 2006..2% Hispanics; P < 0.005). Nutritional deficiencies are common in patients undergoing Roux-en-Y gastric bypass, and these deficiencies should be detected and corrected early to avoid postoperative complications...
- Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric bandingJudith Korner
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Surg Obes Relat Dis 3:597-601. 2007....
- A review of laparoscopic sleeve gastrectomy for morbid obesityXinzhe Shi
Centre for Advancement of Minimally Invasive Surgery CAMIS, Royal Alexandra Hospital, 10240 Kingsway Ave, Edmonton, AB T5H 3V9, Canada
Obes Surg 20:1171-7. 2010Laparoscopic sleeve gastrectomy (LSG) is an innovative approach to the surgical management of morbid obesity. Weight loss may be achieved by restrictive and endocrine mechanisms...
- A 10-year experience with laparoscopic gastric banding for morbid obesity: high long-term complication and failure ratesM Suter
Department of Surgery, Hopital du Chablais, Aigle Monthey, Switzerland
Obes Surg 16:829-35. 2006..and morbidity, laparoscopic gastric banding (LGB) has been considered by many as the treatment of choice for morbid obesity. Few long-term studies have been published...
- Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism?Mario Rotondi
Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri IRCCS, ISPESL Laboratory for Endocrine Disruptors, Chair of Endocrinology, University of Pavia, Pavia, Italy
Eur J Endocrinol 160:403-8. 2009b>Morbid obesity (body mass index (BMI)> or =40 kg/m(2)) is associated with thyroid function disturbances, with a high rate of subclinical hypothyroidism (SH) being the most consistently reported...
- The Magenstrasse and Mill operation for morbid obesityDavid Johnston
The Academic Department of Surgery, Leeds General Infirmary and the University of Leeds, Leeds, England, UK
Obes Surg 13:10-6. 2003..Normal antral grinding of solid food and antro-pyloro-duodenal regulation of gastric emptying and secretion are preserved...
- Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight lossM Nannipieri
Department of Internal Medicine, University of Pisa, Pisa, Italy
Int J Obes (Lond) 33:1001-6. 2009....
- The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgeryHector F Escobar-Morreale
Department of Endocrinology, Hospital Ramon y Cajal, Madrid E 28034, Spain
J Clin Endocrinol Metab 90:6364-9. 2005The polycystic ovary syndrome (PCOS) is frequently associated with obesity. However, there are very few data about PCOS in morbid obesity, especially with regard to its evolution after bariatric surgery.
- Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesityAdeline Bertola
Institut National de la Sante et de la Recherche Medicale, U895, Team 8, Hepatic Complications in Obesity, Nice, France
Diabetes 58:125-33. 2009..We aimed to determine the expression pattern of OPN and its receptor CD44 in obese patients and mice according to insulin resistance and liver steatosis...
- Morbid obesity and tracheal intubationJay B Brodsky
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94303, USA
Anesth Analg 94:732-6; table of contents. 2002..We conclude that obesity alone is not predictive of tracheal intubation difficulties...
- Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesityM C Alessi
Laboratoire d Hématologie Faculté de Médecine Timone, Centre Hospitalier Universitaire Timone, Marseille, France
Diabetes 49:1374-80. 2000..This increased PAI-1 expression could be the result of tissue cytokine disturbances, such as elevated TGF-beta1 expression...
- Anesthetic considerations for bariatric surgeryBabatunde O Ogunnaike
Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, 75390, USA
Anesth Analg 95:1793-805. 2002
- Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASHSoumeya Bekri
Laboratoire d Hépato Gastroentérologie, EA1186, Faculté Médecine de Nice, Nice, France
Gastroenterology 131:788-96. 2006..We have investigated the possible involvement of hepcidin in massive obesity, a state of chronic low-grade inflammation. Three groups of severely obese patients with or without diabetes or nonalcoholic steatohepatitis were investigated...
- Results of laparoscopic sleeve gastrectomy (LSG) at 1 year in morbidly obese Korean patientsSang Moon Han
Department of Surgery, Kangnam CHA Hospital, School of Medicine, Pochon CHA University, Seoul, South Korea
Obes Surg 15:1469-75. 2005..Therefore, the treatment plan should be differentiated, and the surgery for morbid obesity should be carefully chosen...
- Short- and mid-term outcomes of sleeve gastrectomy for morbid obesity: the experience of the Spanish National RegistryRaquel Sanchez-Santos
Servicio de Cirugía General y Digestiva, Complejo Hospitalario de Pontevedra, C Mourente s n, Pontevedra 36021, Spain
Obes Surg 19:1203-10. 2009..However, mid- and long-term results are still unknown. A National Registry has been created in Spain to achieve information on the outcomes of this bariatric procedure...
- The physiologic effects of pneumoperitoneum in the morbidly obeseNinh T Nguyen
Department of Surgery, University of California, Irvine, Medical Center, Orange, CA 92868, USA
Ann Surg 241:219-26. 2005..To review the physiologic effects of carbon dioxide (CO2) pneumoperitoneum in the morbidly obese...
- Comprehensive interview assessment of eating behavior 18-35 months after gastric bypass surgery for morbid obesityMartina de Zwaan
Department of Psychosomatic Medicine and Psychotherapy, University Hospital of Erlangen, Erlangen, Germany
Surg Obes Relat Dis 6:79-85. 2010....
- Fatal pulmonary embolism after bariatric operations for morbid obesity: a 24-year retrospective analysisJames A Sapala
Department of Surgery, Harper University Hospital, Detroit Medical Center and Wayne State University School of Medicine, Detroit, MI, USA
Obes Surg 13:819-25. 2003Pulmonary embolism (PE) is a leading cause of death following gastric bypass operations for morbid obesity. Although its incidence appears to be stable, the number of bariatric operations performed annually is increasing considerably; ..
- Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgeryCaterina Guidone
Dipartimento di Medicina Interna, Catholic University, Largo A Gemelli, 8, 00168 Rome, Italy
Diabetes 55:2025-31. 2006..2 diabetes after bariatric surgery, which was reported as an additional benefit of the surgical treatment for morbid obesity. With this question in mind, insulin sensitivity, using euglycemic-hyperinsulinemic clamp, and insulin ..
- Laparoscopic sleeve gastrectomy for morbid obesity: a reviewSandeep Aggarwal
Division of Laparoscopic Surgery, Department of Surgery, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Surg Obes Relat Dis 3:189-94. 2007
- [Surgery for morbid obesity: 2. Complications. Results of a Technologic Evaluation by the ANAES]S Msika
Service de Chirurgie Generale et Digestive, Hopital Louis Mourier Colombes
J Chir (Paris) 140:4-21. 2003..has increased markedly in France in recent years, partly due to a better appreciation of the problem of morbid obesity but also due to the commercial introduction of adjustable gastric banding devices which can be placed by ..
- Outcomes of sleeve gastrectomy for morbid obesity: a safe and effective procedure?Jon Armstrong
Department of General Surgery, Royal Perth Hospital, 6 10 McCourt St, West Leederville, Perth, WA 6007, Australia
Int J Surg 8:69-71. 2010Sleeve gastrectomy is being performed with increasing frequency in Australia for the treatment of morbid obesity. The aims of this study were to show that sleeve gastrectomy can be performed safely with a low rate of complications and ..
- The learning curve for laparoscopic Roux-en-Y gastric bypass is 100 casesP Schauer
Department of Surgery, The Minimally Invasive Surgery Center, University of Pittsburgh, Presbyterian University Hospital, C 800, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
Surg Endosc 17:212-5. 2003..The purpose of this study was to determine the effect of operative experience on perioperative outcomes for laparoscopic Roux-en-Y gastric bypass (LGB)...
- Type 2 diabetes mellitus and the metabolic syndrome following sleeve gastrectomy in severely obese subjectsJ Vidal
Obesity Unit, Hospital Clinic Universitari, Villarroel 170, Barcelona, Spain
Obes Surg 18:1077-82. 2008..Data on the effectiveness of sleeve gastrectomy in improving or resolving type 2 diabetes mellitus (T2DM) and the metabolic syndrome (MS) are scarce...
- Anesthesia for a patient with morbid obesity using dexmedetomidine without narcoticsRoger E Hofer
Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
Can J Anaesth 52:176-80. 2005..To describe the anesthetic management of a patient with extreme obesity undergoing bariatric surgery whose intraoperative narcotic management was entirely substituted with dexmedetomidine...
- High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosisJean Marc Sabate
Service d Hepato Gastroenterologie, AP HP, Hopital Louis Mourier, Universite Paris 7, 92700 Colombes, France
Obes Surg 18:371-7. 2008..Small intestinal bacterial overgrowth (SIBO) could be related to NAFLD. Our aim was to determine the prevalence of SIBO and its relationship with liver lesions in morbidly obese patients...
- Port complications following laparoscopic adjustable gastric banding for morbid obesityAndrei Keidar
Department of Surgery B, Sourasky Medical Center, Tel Aviv, Israel
Obes Surg 15:361-5. 2005..Port complications are considered to be minor; however, few studies have analyzed them, and the optimal technique of port implantation and management has not been elucidated...
- Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight lossRaffaella Cancello
INSERM Avenir, Paris 6 University EA3502 and Human Research Center on Nutrition CRNH, Hotel Dieu Hospital, AP HP, Paris, France
Diabetes 54:2277-86. 2005..We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT...
- Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric bandingM V Heinonen
Department of Biotechnology Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, 70211 Kuopio, Finland
Regul Pept 130:7-13. 2005..In addition, we measured in a subgroup of these patients in the same individual orexin-A and leptin plasma levels one year after gastric banding surgery...
- Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndromeK Zwirska-Korczala
Department of Physiology, Zabrze, Medical University of Silesia, Katowice, Poland
J Physiol Pharmacol 58:13-35. 2007....
- Lap-Band erosion: incidence and treatmentE Niville
Department of Abdominal Surgery, Ziekenhuis Oost Limburg, Genk, Belgium
Obes Surg 11:744-7. 2001Laparoscopic adjustable gastric banding (LAGB) is an effective and safe surgical treatment for morbid obesity. Migration of the band through the stomach wall is a well-known late complication that may jeopardize the aim of the treatment--..
- The laparoscopic adjustable gastric band (Lap-Band): a prospective study of medium-term effects on weight, health and quality of lifePaul E O'Brien
Monash Department of Surgery, Alfred Hospital, Melbourne 3181, Australia
Obes Surg 12:652-60. 2002..Obesity is now one of our major public health problems. Effective and acceptable treatment options are needed. The Lap-Band system is placed laparoscopically and allows adjustment of the level of gastric restriction...
- Diagnosis and management of gastric leaks after laparoscopic sleeve gastrectomy for morbid obesityJeremy T Tan
Department of General Surgery, Sir Charles Gairdner Hospital, Hospital Ave, Western Australia, Australia
Obes Surg 20:403-9. 2010..LSG) is increasingly being recognised as a valid stand-alone procedure for the surgical management of morbid obesity. The leak rate from the gastric staple line ranges from 1.4% to 20%...
- Early experience with two-stage laparoscopic Roux-en-Y gastric bypass as an alternative in the super-super obese patientJ P Regan
Division of Laparoscopic Surgery, Department of Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1103, New York, NY, USA
Obes Surg 13:861-4. 2003..Current limited experience exists with a two-stage biliopancreatic diversion and duodenal switch in the supersuper obese patient, and we now present our early experience with a two-stage gastric bypass for these patients...
- Complications after sleeve gastrectomy for morbid obesityEldo E Frezza
Department of Surgery, The University of Alabama at Birmingham, 700 South 19th Street, VAMC 112, Birmingham, AL 35233, USA
Obes Surg 19:684-7. 2009..Laparoscopic sleeve gastrectomy (LSG) is an increasingly used bariatric surgical procedure...
- Results of laparoscopic sleeve gastrectomy: a prospective study in 135 patients with morbid obesityDavid Fuks
Federation of Digestive Diseases, Amiens North Hospital, University of Picardy, Amiens, France
Surgery 145:106-13. 2009Sleeve gastrectomy is a new restrictive bariatric procedure increasingly indicated in the treatment of morbid obesity. The authors report their experience of laparoscopic sleeve gastrectomy (LSG), evaluate the efficacy of this procedure ..
- Laparoscopic sleeve gastrectomy: a multi-purpose bariatric operationAniceto Baltasar
Clínica San Jorge and Alcoy Hospital, Chief of the Surgical Service, Alcoy, Spain
Obes Surg 15:1124-8. 2005..The use of the laparoscopic sleeve gastrectomy (LSG), a restrictive operation, in different settings, is presented...
- Effectiveness of laparoscopic sleeve gastrectomy (first stage of biliopancreatic diversion with duodenal switch) on co-morbidities in super-obese high-risk patientsGianfranco Silecchia
Department of Surgery P Stefanini, University La Sapienza of Rome, Rome, Italy
Obes Surg 16:1138-44. 2006....
- Meta-analysis: surgical treatment of obesityMelinda A Maggard
Southern California Evidence Based Practice Center, RAND Health Division, Santa Monica, California, USA
Ann Intern Med 142:547-59. 2005..Controversy exists regarding the effectiveness of surgery for weight loss and the resulting improvement in health-related outcomes...
- Potential of surgery for curing type 2 diabetes mellitusFrancesco Rubino
IRCAD European Institute of Telesurgery, Strasbourg, France
Ann Surg 236:554-9. 2002To review the effect of morbid obesity surgery on type 2 diabetes mellitus, and to analyze data that might explain the mechanisms of action of these surgeries and that could answer the question of whether surgery for morbid obesity can ..
- Effect of prepregnancy body mass index categories on obstetrical and neonatal outcomesHaim A Abenhaim
Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital, Women s Pavillion, 687 Ave des Pins Ouest, F4 46, Montreal, QC, Canada, PQ H3A 1A1
Arch Gynecol Obstet 275:39-43. 2007..To examine the association between body mass index (BMI) and obstetrical and neonatal outcomes...
- Vitamin D, PTH, and the metabolic syndrome in severely obese subjectsSergio Rueda
Obesity Unit, Hospital Clinic Universitari, Villarroel 170, 08036 Barcelona, Spain
Obes Surg 18:151-4. 2008..The objective of this study was to evaluate the association between the metabolic syndrome (MS) and vitamin D [25(OH)D] or parathyroid hormone (PTH) levels in severely obese subjects...
- Clinical and cost effectiveness of surgery for morbid obesity: a systematic review and economic evaluationA Clegg
Southampton Health Technology Assessments Centre SHTAC, Wessex Institute for Health Research and Development, University of Southampton, Southampton, UK
Int J Obes Relat Metab Disord 27:1167-77. 2003To assess the clinical and cost effectiveness of surgery for people with morbid obesity.
- Laparoscopic Roux-en-Y versus mini-gastric bypass for the treatment of morbid obesity: a prospective randomized controlled clinical trialWei Jei Lee
Department of Surgery, En Chu Kong Hospital and School of Nursing, Taiwan
Ann Surg 242:20-8. 2005This prospective, randomized trial compared the safety and effectiveness of laparoscopic Roux-en-Y gastric bypass (LRYGBP) and laparoscopic mini-gastric bypass (LMGBP) in the treatment of morbid obesity.
- Weight loss maintenance in severely obese adults after an intensive lifestyle intervention: 2- to 4-year follow-upTore Christiansen
Department of Medicine and Endocrinology C, Aarhus Sygehus, Aarhus University Hospital, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
Obesity (Silver Spring) 15:413-20. 2007..To evaluate the long-term weight loss maintenance after 2 to 4 years in severely obese subjects after a lifestyle intervention at a weight loss camp in Denmark...
- Symmetrical pouch dilatation after laparoscopic adjustable gastric banding: incidence and managementWendy A Brown
Centre for Obesity Research and Education, Monash University, Melbourne, Australia
Obes Surg 18:1104-8. 2008..Since popularization of the pars flaccida approach and improved anterior fixation, it is our impression that the problem of symmetrical dilatation of the proximal gastric pouch has become more important...
- Review: long-term impact of bariatric surgery on body weight, comorbidities, and nutritional statusMeena Shah
Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9052, USA
J Clin Endocrinol Metab 91:4223-31. 2006....
- Trends in bariatric surgical proceduresHeena P Santry
Department of Surgery, University of Chicago, Chicago, Ill, USA
JAMA 294:1909-17. 2005The increasing prevalence and associated sociodemographic disparities of morbid obesity are serious public health concerns...
- The impact of morbid obesity on patient outcomes after total knee arthroplastyVaishnav Rajgopal
Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
J Arthroplasty 23:795-800. 2008..05), they showed greater improvement in function compared with non-morbidly obese patients. Morbid obesity does not affect 1-year outcomes in patients who have had a total knee arthroplasty.
- Treatment of morbid obesity with the Transcend Implantable Gastric Stimulator (IGS): a prospective surveyFranco Favretti
Department of Medical and Surgical Sciences, University of Padua, Italy
Obes Surg 14:666-70. 2004..The implantable gastric stimulator (IGS), a pacemaker-like device, has been found to be safe and effective to induce and maintain weight loss. We present our experience with 20 morbidly obese patients...
- Result of a national audit of bariatric surgery performed at academic centers: a 2004 University HealthSystem Consortium Benchmarking ProjectNinh T Nguyen
Department of Surgery, University of California Irvine Medical Center, Orange 92868, USA
Arch Surg 141:445-9; discussion 449-50. 2006..Bariatric surgery performed at US academic centers is safe and associated with low mortality...
- The relationship between hospital volume and outcome in bariatric surgery at academic medical centersNinh T Nguyen
Department of Surgery, University of California, Irvine, Medical Center, Orange, CA, USA
Ann Surg 240:586-93; discussion 593-4. 2004..To examine the effect of hospital volume of bariatric surgery on morbidity, mortality, and costs at academic centers...
- Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgeryDavid E Cummings
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
Surg Obes Relat Dis 1:358-68. 2005
- Association of morbid obesity and weight change over time with cardiovascular survival in hemodialysis populationKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Kidney Dis 46:489-500. 2005..However, the association between changes in weight over time and prospective mortality is not known...
- Effect of surgically-induced weight loss on leukocyte indicators of chronic inflammation in morbid obesityD R Cottam
Nassau University Medical Center, New York, USA
Obes Surg 12:335-42. 2002Recent evidence suggests that morbid obesity is a chronic inflammatory condition that may be associated with immune dysfunction...
- Morbid obesity and inflammation: a prospective study after adjustable gastric banding surgeryRenata Ramalho
Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4202, Porto, Portugal
Obes Surg 19:915-20. 2009..Inflammatory status underlying obesity seems to be implicated in several aspects of metabolic syndrome...
- Morbid obesity in the medical ICUA El-Solh
Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, James P Nolan Clinical Research Center, University at Buffalo School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
Chest 120:1989-97. 2001..To describe the clinical course, complications, and prognostic factors of morbidly obese patients admitted to the ICU compared to a control group of nonobese patients...
- Laparoscopic adjustable gastric banding for the treatment of morbid (grade 3) obesity and its metabolic complications: a three-year studyAntonio E Pontiroli
Universita degli Studi di Milano, Cattedra di Medicina Interna, Italy
J Clin Endocrinol Metab 87:3555-61. 2002....
- National variations in morbid obesity and bariatric surgery useBenjamin K Poulose
Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
J Am Coll Surg 201:77-84. 2005Exploring bariatric surgery use provides data on effective treatment allocation. This study analyzed national rates of bariatric surgery use and the burden of morbid obesity by gender, census region, and age.
- Bariatric surgery and long-term control of morbid obesityRobert E Brolin
Bariatric Surgery, Saint Peter s University Hospital, 254 Easton Ave, New Brunswick, NJ 08903, USA
JAMA 288:2793-6. 2002
- Further evidence for the role of ENPP1 in obesity: association with morbid obesity in FinnsKaisa Valli-Jaakola
Department of Medicine and Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland
Obesity (Silver Spring) 16:2113-9. 2008..haplotype composed of SNPs rs1800949 and rs943003 showed suggestive evidence for association with adult-onset morbid obesity in Finns...
- Child and parental self-monitoring as determinants of success in the treatment of morbid obesity in low-income minority childrenJulie N Germann
La Rabida Children s Hospital, E 65th St at Lake Michigan, Chicago, Illinois 60649, USA
J Pediatr Psychol 32:111-21. 2007To examine self-monitoring by children and parents as related to weight control over 6 months within a long-term multidisciplinary program for low-income minority children with morbid obesity.
- Effects of weight loss after bariatric surgery for morbid obesity on vascular endothelial growth factor-A, adipocytokines, and insulinNuria García de la Torre
Department of Endocrinology, Hospital Clinico Universitario San Carlos, Martin Lagos s n, 28040 Madrid, Spain
J Clin Endocrinol Metab 93:4276-81. 2008..Some adipocytokines and hormones also have an effect on vascular development...
- Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormalitiesMerce Miranda
Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, IISPV, 43007 Tarragona, Spain
Metabolism 58:1762-8. 2009..AQP7 and hepatic AQP9 messenger RNA expression and the presence of glucose abnormalities simultaneously in morbid obesity. Adipose tissue (subcutaneous [SAT] and visceral [VAT]) and liver biopsies from the same patient were obtained ..
- Thyroid function in humans with morbid obesityMarina A Michalaki
Division of Endocrinology, Department of Medicine, University Hospital, Patras, Greece
Thyroid 16:73-8. 2006..5%). The morbidly obese subjects have higher levels of T3, FT3, T4, and TSH, probably the result of the reset of their central thyrostat at higher level...
- Endoscopic and histologic findings of the foregut in 426 patients with morbid obesityAttila Csendes
Department of Surgery and Pathology, University Hospital, Santiago, Chile
Obes Surg 17:28-34. 2007..In this operation, the distal bypassed stomach is left in situ. We studied pre-operative clinical, endoscopic and histologic findings in a consecutive group of morbidly obese patients prior to bariatric surgery...
- Mid-term follow-up after sleeve gastrectomy as a final approach for morbid obesityEnrique Arias
The Bariatric and Metabolic Institute, Section of Minimally Invasive and Endoscopic Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA
Obes Surg 19:544-8. 2009In previous publications, we demonstrated the safety and short-term efficacy of laparoscopic sleeve gastrectomy (LSG) as a final step in the treatment of morbid obesity (MO). This study aimed to assess the mid-term efficacy of LSG.
- An overview of the management of morbid obesityS J W Monkhouse
Department of Surgery, Southmead Hospital, Bristol BS10 5NB, UK
Postgrad Med J 85:678-81. 2009..Prevention must be at the heart of any strategy to manage obesity, but, for established cases, surgery is taking centre stage and will continue to flourish as new techniques and procedures are developed...
- Laparoscopic total gastric vertical plication in morbid obesityMohammad Talebpour
Laparoscopic Surgical Ward, Sina Hospital, Tehran Medical University, Tehran, Iran
J Laparoendosc Adv Surg Tech A 17:793-8. 2007..It has the same result of weight loss as others with minimal risk of complication and very low cost, especially in developing countries...
- Gastric pouch carcinoma after gastric bypass for morbid obesityM Toledano Trincado
Department of General Surgery, Medina del Campo Hospital Valladolid, Spain
Obes Surg 15:1215-7. 2005..5 years after, gastric carcinoma was discovered in the gastric pouch. Because of varied symptoms following bariatric surgery, patients may not present promptly with symptoms related to a gastric carcinoma...
- Laparoscopic duodenal switch for morbid obesityMichel Gagner
New York Presbyterian Hospital, Department of Surgery, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
Expert Rev Med Devices 3:105-12. 2006..5%, and operative times close to 200 min. Laparoscopic duodenal switch is likely to increase in popularly for the treatment of morbid obesity, especially with the recent advent of laparoscopic sleeve gastrectomy for higher-risk patients.
- Insurance-mandated preoperative dietary counseling does not improve outcome and increases dropout rates in patients considering gastric bypass surgery for morbid obesityMohammad K Jamal
Department of Surgery, Division of Minimally Invasive Surgery, Virginia Commonwealth University Health System, Richmond, Virginia, USA
Surg Obes Relat Dis 2:122-7. 2006..We compared outcomes of GBP patients undergoing a mandatory 13 weeks of PDC (n = 72) to a contemporaneous group of patients with no such requirement (no-PDC; n = 252) who underwent operation between January 2000 and December 2002...
- Effect of circulatory congestion on the components of pulmonary diffusing capacity in morbid obesityBeno W Oppenheimer
Division of Pulmonary and Critical Care Medicine and Bellevue Hospital Chest Service, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Obesity (Silver Spring) 14:1172-80. 2006..We examined DLCO and its partition into Vc and Dm in 13 severely obese subjects (BMI = 51 +/- 14 kg/m2) without manifest cardiopulmonary disease before and after surgically induced weight loss...
- Minimally invasive surgery for morbid obesityFredrick Brody
The George Washington University Medical Center, Department of Surgery, Washington, DC 20037, USA
Cleve Clin J Med 71:289, 293, 296-8. 2004In patients with morbid obesity, surgery is the only treatment known to produce sustained weight loss and to reduce comorbidities...
- Laryngoscopy and morbid obesity: a comparison of the "sniff" and "ramped" positionsJeremy S Collins
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA
Obes Surg 14:1171-5. 2004..The effect of patient position on the view obtained during laryngoscopy was investigated...
- Respiratory restriction and elevated pleural and esophageal pressures in morbid obesityNegin Behazin
Dept of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Appl Physiol (1985) 108:212-8. 2010..High P(Es) suggests high P(Pl) in such individuals. Lung and respiratory system compliances are low because of breathing at abnormally low lung volumes...
- Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesityK Clement
Centre National de la Recherche Scientifique, Unité CNRS EP10, Institut Pasteur, Lille, France
N Engl J Med 333:352-4. 1995..The potential relevance of this receptor to obesity in humans led us to screen obese French patients for a recently identified mutation in the gene for the receptor...
- Impact of morbid obesity on chewing abilityJ L Veyrune
Univ Clermont1, EA 3847, Faculté d Odontologie, 11bvd Charles de Gaulle, 63000, Clermont Ferrand, France
Obes Surg 18:1467-72. 2008..This study compared the chewing parameters in a group of obese adult patients scheduled for gastric bypass surgery with those of a control group...
- Changes in liver histology accompanying massive weight loss after gastroplasty for morbid obesityCharalabos Stratopoulos
First Department of Surgery and Transplant Center, Evagelismos Hospital of Athens, Greece
Obes Surg 15:1154-60. 2005Nonalcoholic steatohepatitis (NASH) is common in morbid obesity. Our goal was to evaluate the alterations in liver histology and biochemistry before and after weight loss in 51 morbidly obese patients following Mason's vertical banded ..
- Binge eating disorder in extreme obesityL K G Hsu
Department of Psychiatry, New England Medical Center, Boston, Massachusetts 02111, USA
Int J Obes Relat Metab Disord 26:1398-403. 2002....
- Surgery for morbid obesityJohn M H Bennett
Department of Upper Gastrointestinal Surgery, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK
Postgrad Med J 83:8-15. 2007The prevalence of morbid obesity in the UK population is rising, bringing with it increased levels of cardiovascular disease, diabetes, arthritis and early mortality...
- Depression in association with severe obesity: changes with weight lossJohn B Dixon
Department of Surgery, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
Arch Intern Med 163:2058-65. 2003..The relationship between depression and severe obesity is unclear. We examined depression before and after surgically induced weight loss...
- Physiologic correlates of dyspnea in patients with morbid obesityF Collet
Lung Function Department, Calmette Hospital, Lille University, France
Int J Obes (Lond) 31:700-6. 2007..This study was undertaken to determine the relationships between dyspnea and pulmonary function including inspiratory muscle endurance (IME) in morbidly obese patients before bariatric surgery...
- Deep brain stimulation compared with bariatric surgery for the treatment of morbid obesity: a decision analysis studyJared M Pisapia
Department of Neurosurgery, Center for Weight and Eating Disorders, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
Neurosurg Focus 29:E15. 2010Roux-en-Y gastric bypass is the gold standard treatment for morbid obesity, although failure rates may be high, particularly in patients with a BMI > 50 kg/m(2)...
- Psychosocial consequences of weight loss following gastric banding for morbid obesityJ F Kinzl
Department of Psychiatry, Innsbruck University Hospital, Innsbruck, Austria
Obes Surg 13:105-10. 2003This study was performed to determine what consequences surgery for morbid obesity has on weight loss, problems in eating behavior, quality of life, physical appearance and mental state.
- Effect of gastric bypass on Barrett's esophagus and intestinal metaplasia of the cardia in patients with morbid obesityAttila Csendes
Department of Surgery, Clinical Hospital University of Chile, Santos Dumont 999, Santiago, Chile
J Gastrointest Surg 10:259-64. 2006Gastric bypass in patients with morbid obesity should be an excellent antireflux procedure, because no acid is produced at the small gastric pouch and no duodenal reflux is present, due to the long Roux-en-Y limb...
- Gender variations of body composition, muscle strength and power output in morbid obesityC L Lafortuna
Istituto di Bioimmagini e Fisiologia Molecolari del Consiglio Nazionale delle Ricerche, Segrate, Milano, Italy
Int J Obes (Lond) 29:833-41. 2005..Motor capabilities are reduced in obese (OB) individuals, and this impairment may result also from quantitative variation of muscle mass due to alterations in body composition...
- Vitamin D deficiency is associated with the metabolic syndrome in morbid obesityJosé I Botella-Carretero
Department of Clinical Nutrition, Hospital Ramon y Cajal, 28034 Madrid, Spain
Clin Nutr 26:573-80. 2007..However, it is not known whether this possible association of vitamin D deficiency with the metabolic syndrome is still present at very high degrees of obesity, as in morbidly obese patients...
- Sleeve gastrectomy for morbid obesityAndrew A Gumbs
New York Presbyterian Hospital, Division of Laparoscopy, NY, USA
Obes Surg 17:962-9. 2007The rising prevalence of morbid obesity and the increased incidence of super-obese patients (BMI >50 kg/m2) seeking surgical treatments has led to the search for surgical techniques that provide adequate EWL with the least possible ..
- Influence of morbid obesity on the single-dose pharmacokinetics of daptomycinManjunath P Pai
College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
Antimicrob Agents Chemother 51:2741-7. 2007..Further studies of daptomycin pharmacokinetics in morbidly obese patients with acute bacterial infections and impaired renal function are necessary to better predict appropriate dosage intervals...
- Outcome after laparoscopic adjustable gastric banding - 8 years experienceR Weiner
Krankhenhaus Sachsenhausen, Frankfurt Center for Minimally Invasive Surgery, Section of Bariatric Surgery, Germany
Obes Surg 13:427-34. 2003Laparoscopic adjustable gastric banding (LAGB) has been our choice operation for morbid obesity since 1994...
- Bariatric surgery for morbid obesityEric J Demaria
Duke Weight Loss Surgery Center and the Duke Endosurgery Center, Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 356:2176-83. 2007
- The biliopancreatic diversion with the duodenal switch: results beyond 10 yearsDouglas S Hess
Wood County Hospital, Bowling Green, OH, USA
Obes Surg 15:408-16. 2005..It is our opinion that the BPD/DS should be considered as the gold standard bariatric operation...
- Is it feasible to reach the bypassed stomach after Roux-en-Y gastric bypass for morbid obesity? The use of the double-balloon enteroscopeP Sakai
Endoscopy Unit, Dept of Gastroenterology, Sao Paulo University Medical School, Hospital das Clinicas, Sao Paulo, Brazil
Endoscopy 37:566-9. 2005Endoscopic evaluation of the excluded stomach after Roux-en-Y gastric bypass surgery for morbid obesity is a challenge, and the pathological changes that take place in the bypassed stomach are unclear...
- Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver diseaseJosé I Botella-Carretero
Unit of Obesity Surgery, Department of Endocrinology and Nutrition, Hospital Universitario Ramon y Cajal, Carretera de Colmenar Km 9 1, 28034 Madrid, Spain
Obes Surg 20:69-76. 2010....
- Role of the Omentum in the Treatment of Morbid ObesityNaji Abumrad; Fiscal Year: 2009..Parameters will be correlated with time dependent changes in inflammatory markers (e.g. CRP, IL-6, TNF-a2R, etc.) and with tissue insulin responsiveness using hyperinsulinemic euglycemic clamps. ..
- The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intakeNILS WG LAMBRECHT; Fiscal Year: 2012..Chronically increased food intake contributes to morbid obesity, chronically decreased food intake contributes to cachectic wasting as severe complication in overwhelming ..
- RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue AxisNaji N Abumrad; Fiscal Year: 2013..The information derived could lead to the combination of less invasive surgical procedures with pharmacologic manipulation of the levels of acylated ghrelin and/or leptin for the treatment of morbid obesity.
- Weight management for improved pregnancy outcomesVictor J Stevens; Fiscal Year: 2012..Whereas morbid obesity was once rare among pregnant women, a rapidly increasing proportion of obstetrics patients now have levels of ..
- Human Cell-Based Models of Primary Adipocyte DisordersCHAD ALBERT COWAN; Fiscal Year: 2013..Interestingly, most of these clinical symptoms are also found in individuals with morbid obesity. While the physiological consequences of LMNA and PLIN1 mutations have been described, very little about the ..
- Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig ModelWilliam P Melega; Fiscal Year: 2010..of obese individuals (body mass index, BMI >30), but surgical interventions are often needed to treat morbid obesity (clinically severe, BMI >40)...
- A randomized trial of bariatric surgery for the treatment of sleep apneaSanjay R Patel; Fiscal Year: 2013..Bariatric surgery has been approved as treatment for OSA in patients with co-morbid obesity and in small case series, appears to produce substantial improvements...
- Intestinal satiation in Roux-en-Y gastric bypass rats: brain mechanisms and sex dThomas Alexander Lutz; Fiscal Year: 2013..surgery, in particular Roux-en-Y gastric bypass (RYGB) surgery, is currently the only effective therapy for morbid obesity, which is a grave and growing national health problem...
- Role of Human Intestinal Microbiota on Success of Surgical Weight Loss ProceduresBRUCE EDWARD RITTMANN; Fiscal Year: 2013..Bariatric surgery is currently the only available treatment for morbid obesity that consistently achieves and maintains substantial weight loss, decreases the incidence and severity of ..
- Bariatric Surgery for Morbid Obesity: Clinical and Pathophysiologic ConsequencesPAUL DAVID BERK; Fiscal Year: 2010..abstract_text> ..
- RNA editing-mediated modulation of serotonin 2C receptor protein expressionRANDI JO ULBRICHT; Fiscal Year: 2011..cognitive deficits, decreased somatic growth, neonatal muscular hypotonia, and hyperphagia associated with morbid obesity. Interestingly, these mutant mice exhibit an unprecedented 40- to 70-fold increase in 5HT2C receptor density ..
- Adiponectin Polymorphisms, Insulin Resistance, and Pharmacokinetics in ObesityJerry Ingrande; Fiscal Year: 2013The incidence of morbid obesity has tripled over the last three decades in the developed world. In the United States alone, 65% of the population is overweight or obese...
- Understanding the role of bile as a mechanism for improved glucose homeostasis foAPRIL DAWN STRADER; Fiscal Year: 2010..Bariatric surgery remains the most effective treatment for morbid obesity. In addition, bariatric surgery such as Roux-en Y Gastric Bypass causes the immediate resolution of type-II ..
- Architectural Basis of Leptin Transmembrane SignalingGeorgios Skiniotis; Fiscal Year: 2013..food intake and stimulates energy expenditure, while functional defects in either leptin or L-R result in morbid obesity, hyperglycemia, decreased insulin sensitivity, and hyperlipidemia...
- Role of Sim1 in Hyperphagic ObesityBassil M Kublaoui; Fiscal Year: 2010..We are trying understand how the brain regulates our eating behavior. We study a gene that was found to cause morbid obesity in a girl. We are using a mouse model of this gene to understand how it causes obesity.
- Genetic Determinants of Weight Loss and Resolution of Co-MorbiditiesGlenn S Gerhard; Fiscal Year: 2013..b>Morbid obesity (BMI>40 kg/m2), which afflicts over 5% of the U.S...
- Gastric bypass surgery alters the regulation of food rewardAndras Hajnal; Fiscal Year: 2013Gastric bypass surgery (GBS) is an exceptionally successful therapy for morbid obesity and type 2 diabetes...
- Role of Ileum in Reducing Obesity Related ComorbiditiesRohit Kohli; Fiscal Year: 2013..States such that bariatric surgery has become an accepted therapeutic option for adults and adolescents with morbid obesity. Bariatric surgery provides significant metabolic benefits, including resolution of type-2 diabetes and marked ..
- Rare disease CRC for new therapies and new diagnosticsALAN KENNETH PERCY; Fiscal Year: 2013..studies according to genotype, 2) to perform natural history studies on non-PWS individuals with early-onset morbid obesity (EMO) and compare them with PWS, and 3) to develop parameters and tool for clnical trials...
- Outcomes of Bariatric Surgery among Patients with Bipolar DisorderAmeena T Ahmed; Fiscal Year: 2012..Bariatric surgery is the most effective treatment for morbid obesity. Although BD patients suffer disproportionately from obesity, there is virtually no published data on how ..
- Neural Mechanisms Associated with Nicotine Addiction and Obesity Co-MorbiditiesLaura E Martin; Fiscal Year: 2011..is to increase our understanding of how the neural systems of reward differentially respond in the case of co-morbid obesity and nicotine addiction, which will inform smoking cessation and weight management treatment programs designed ..
- A TELEHEALTH INNOVATION TO SUPPORT WEIGHT LOSS SURGERYVESTA BRUE; Fiscal Year: 2010..S. and an effective treatment for morbid obesity (MO). Close to a quarter-million surgeries are performed annually in the U.S...
- Skeletal health in obesity and after bariatric surgeryELAINE WEI YIN YU; Fiscal Year: 2013DESCRIPTION (provided by applicant): Morbid obesity is an important public health problem, but the complex relationship between obesity and the skeleton is poorly understood...
- Predicting Phenotypic Trajectories in Prader-Willi SyndromeELISABETH MAY DYKENS; Fiscal Year: 2013..disabilities;compulsivity;tantrums;irritability;growth hormone dysfunction;hyperphagia;and increased risks of morbid obesity, psychosis, and autism spectrum disorders (ASD)...
- Gastric Sleeve Magnetic ImplantJose Navia; Fiscal Year: 2010..In response, there has been increasing interest in the surgical treatment of morbid obesity with the application of laparoscopic techniques...
- MHIRT: Training GrantCHARLES L ORTIZ; Fiscal Year: 2013..These include: 1) morbid obesity and related conditions such as diabetes, cardiovascular disease and renal insufficiency;2) early childhood ..
- Neuroanatomic Studies in Prader-Willi Syndrome and Early-onset ObesityJennifer L Miller; Fiscal Year: 2012..A group of children with early-onset morbid obesity of unknown origin (EMO) will serve as a comparison group to further evaluate our hypothesis that obesity, ..
- Translating Dietary Trials into the CommunityAlain Bertoni; Fiscal Year: 2009..diet and/or a lower BP goal than 140/90, including persons with diabetes, heart failure, renal failure, morbid obesity (BMI>45) or those who are extremely underweight (BMI<18.5)...
- Neural-Specific Regulation of POMC Gene ExpressionMalcolm Low; Fiscal Year: 2005..Null mutations of the POMC gene have rarely been associated with early onset morbid obesity and hyperphagia in children...
- Leptin in Vascular DiseaseDaniel T Eitzman; Fiscal Year: 2012..Deficiency of hypothalamic leptin receptors or complete deficiency of leptin leads to morbid obesity, therefore therapeutic targeting of all leptin receptors or neutralizing all circulating leptin is not ..
- Extended Effects of Bariatric Surgery on Cognitive FunctionJohn J Gunstad; Fiscal Year: 2010..Bariatric surgery is viewed as an effective intervention for morbid obesity, though its effects on cognition are largely unknown...
- Role of the lower gut in the control of energy balanceHENRY KOOPMANS; Fiscal Year: 2005Surgery has been the most successful treatment for morbid obesity. The main objective of this grant proposal is to determine why lower gut signals generated in bypass surgery have been so successful in causing reduced food intake and body ..
- 'OB' GENE IN HUMANSRobert Considine; Fiscal Year: 2000..Two separate mutations in the mouse ob gene result in the development of morbid obesity. We have sequenced the coding region of the human ob gene and do not detect any mutations in the gene in ..
- THERAPEUTIC POTENTIAL OF INTESTINAL PACING FOR OBESITYJiande Chen; Fiscal Year: 2003..However, currently there is no satisfactory therapy for morbid obesity and there is a great need to explore new therapeutic options...
- GENERAL CLINICAL RESEARCH CENTERPaul Calabresi; Fiscal Year: 1990..metabolism; psychosocial predictors of success and metabolic consequences of gastric bypass surgery in morbid obesity; pharmacokinetics of new antimetabolite regimens for the treatment of psoriasis; the interrelationship of ..
- Impact of gastric bypass surgery on risk of CVD in type 2 diabetes mellitusAlfonso Torquati; Fiscal Year: 2009..Currently, surgical treatment of morbid obesity, termed bariatric surgery, appears to be the only modality that results in significant and sustained weight ..
- LIVER ABNORMALITIES AFTER JEJUNOILEAL BYPASSHerbert Greenlee; Fiscal Year: 1980The etiology of the hepatic abnormalities observed after jejunoileal bypass (JIBP) for morbid obesity is unknown. Three factors individually or in combination may contribute to hepatic injury and dysfunction...
- STRENGTH TRAINING FOLLOWING GASTRIC BYPASS FOR OBESITYAllan Geliebter; Fiscal Year: 2004..Roux-en-Y gastric bypass (RYGB) is now the most common operation to treat morbid obesity in the US...
- MECHANISMS OF UCP REGULATION BY LEPTINThomas Gettys; Fiscal Year: 2001..These mice are characterized by morbid obesity, hyperphagia, low sympathetic output, compromised thermogenic capacity and enhanced energy efficiency...
- RESEARCH IN PRADER-WILLI SYNDROME AND OBESITYDaniel Driscoll; Fiscal Year: 2004..syndrome (especially the gene causing obesity), and to explore the potential role of early childhood morbid obesity plays in mental retardation...
- QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICSRichard Bergman; Fiscal Year: 2005..and insulin resistance, but with limited increase in body weight which represents central obesity but not morbid obesity. We will measure the flux of FFA and cytokines (leptin, TNF-alpha, IL-6) from the visceral adipose depot to ..
- Function and Signaling Mechanisms of Leptin ReceptorsJoyce Repa; Fiscal Year: 2005..Mice and humans with mutation of the gene encoding leptin or its receptor develop morbid obesity. Our long-term objectives are to understand the molecular regulation of mammalian body weight and the ..
- LIFESTYLE ACTIVITY FOR WEIGHT MANAGEMENTThomas Wadden; Fiscal Year: 2003..The predicted superiority of lifestyle activity is based on extensive pilot data and, if confirmed, should significantly improve the management of obesity and its associated health complications. ..
- Behavioral factors in the surgical treatment of obesityThomas Wadden; Fiscal Year: 2009..The study, by examining ghrelin and other appetite-related hormones, also will enhance knowledge of the regulation of body weight following GBP. ..
- BEHAVIOR MODIFICATION AND PHARMACOTHERAPY FOR OBESITYThomas Wadden; Fiscal Year: 2002..If confirmed, the above findings will have important implications for treating obesity in primary care. ..
- Economic Analysis of the Impact of Food AdvertisementsJohn Cawley; Fiscal Year: 2007..Together these data allow us to calculate a precise measure of the advertisements to which each youth was exposed. This will allow us to better estimate how food advertising impacts youth consumption. [unreadable] [unreadable]..
- Adolescent Gastric By-Pass and Diabetic PrecursorsThomas Inge; Fiscal Year: 2006....
- Changes in sexual function following bariatric surgeryDAVID SARWER; Fiscal Year: 2009..The proposed study is innovative, as it will provide new and important information on the long-term effects of bariatric surgery on these important areas of quality of life. ..
- Leptin and Neuroendocrine Gene Regulation in ObesityJudith Korner; Fiscal Year: 2005..Leibel and Dr. Wardlaw, are experienced in basic and clinical research. They are easily accessible, enthusiastic about my projects, and will facilitate my transition to status as an independent investigator. ..
- Leptin and Neuroendocrine Gene Regulation in ObesityJudith Korner; Fiscal Year: 2005..abstract_text> ..
- Obesity, Body Image and Weight MaintenanceDAVID SARWER; Fiscal Year: 2005..These studies have been selected to further develop my knowledge of the treatment of obesity, and the training program has been designed to facilitate my development as an independent investigator in the field of obesity. ..
- Postoperative dietary counseling after bariatric surgeryDAVID SARWER; Fiscal Year: 2005..Results of this study could have a significant impact on the postoperative care of these individuals. ..
- ENTERIC PHYSIOLOGY OF THE TRANSPLANTED GUTMichael Sarr; Fiscal Year: 2007..This proposal will define important, novel neural mechanisms regulating motor and absorptive function in the denervated gut. Selected aspects have translational value to clinical gut transplantation. [unreadable] [unreadable]..
- Insulin resistance in severely obese patientsNana Gletsu Miller; Fiscal Year: 2006..Our findings may provide novel mechanisms that link regional obesity and insulin action. ..
- Nutritional/Inflammatory Evaluation of Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2005....
- Plasma Proteome Profiling of Insulin ResistanceNana Gletsu Miller; Fiscal Year: 2008..Our proposed proteomics analyses are aimed to fill this critical gap in knowledge. [unreadable] [unreadable] [unreadable] [unreadable]..
- Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- "MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD"Allon Friedman; Fiscal Year: 2009..abstract_text> ..
- Beta Cell Adaptation to Stress in Baboon Pancreas After Partial PancreatectomyFRANCO BATTISTA FOLLI; Fiscal Year: 2010....
- The Effect of a Probiotic on Hepatic SteatosisSteven Solga; Fiscal Year: 2004..If the efficacy of probiotics is established one type of chronic liver disease, the possibility that similar biological therapies might benefit other chronic inflammatory states would merit further evaluation. ..
- Alcohol Intake on Insulin Sensitivity and Heart DiseaseSun Kim; Fiscal Year: 2006..Given the morbidity and mortality of insulin resistance and CVD, it becomes important to clarify the role of moderate alcohol consumption to both. ..