morbid obesity

Summary

Summary: The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.

Top Publications

  1. ncbi Marked improvement in asthma after Lap-Band surgery for morbid obesity
    J B Dixon
    Monash University Department of Surgery, Alfred Hospital, Melbourne, Victoria, Australia
    Obes Surg 9:385-9. 1999
  2. ncbi Bariatric surgery: a systematic review and meta-analysis
    Henry Buchwald
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    JAMA 292:1724-37. 2004
  3. ncbi Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal
    A B Goldfine
    Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 92:4678-85. 2007
  4. pmc The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes
    Francesco Rubino
    IRCAD European Institute of Telesurgery, University Louis Pasteur, Strasbourg, France
    Ann Surg 244:741-9. 2006
  5. ncbi A leptin missense mutation associated with hypogonadism and morbid obesity
    A Strobel
    Nat Genet 18:213-5. 1998
  6. ncbi Maternal morbid obesity and the risk of adverse pregnancy outcome
    Marie I Cedergren
    Division of Obstetrics and Gynecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Obstet Gynecol 103:219-24. 2004
  7. ncbi Preoperative nutritional status of patients undergoing Roux-en-Y gastric bypass for morbid obesity
    Louis Flancbaum
    Department of Surgery, St Luke s Roosevelt Hospital Center, New York, NY 11542, USA
    J Gastrointest Surg 10:1033-7. 2006
  8. pmc Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Surg Obes Relat Dis 3:597-601. 2007
  9. doi A review of laparoscopic sleeve gastrectomy for morbid obesity
    Xinzhe Shi
    Centre for Advancement of Minimally Invasive Surgery CAMIS, Royal Alexandra Hospital, 10240 Kingsway Ave, Edmonton, AB T5H 3V9, Canada
    Obes Surg 20:1171-7. 2010
  10. ncbi A 10-year experience with laparoscopic gastric banding for morbid obesity: high long-term complication and failure rates
    M Suter
    Department of Surgery, Hopital du Chablais, Aigle Monthey, Switzerland
    Obes Surg 16:829-35. 2006

Detail Information

Publications339 found, 100 shown here

  1. ncbi Marked improvement in asthma after Lap-Band surgery for morbid obesity
    J B Dixon
    Monash University Department of Surgery, Alfred Hospital, Melbourne, Victoria, Australia
    Obes Surg 9:385-9. 1999
    Asthma and morbid obesity are common chronic conditions that may be related. Laparoscopic banding provides effective weight control of morbid obesity...
  2. ncbi Bariatric surgery: a systematic review and meta-analysis
    Henry Buchwald
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    JAMA 292:1724-37. 2004
    ..About 5% of the US population is morbidly obese. This disease remains largely refractory to diet and drug therapy, but generally responds well to bariatric surgery...
  3. ncbi Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal
    A B Goldfine
    Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 92:4678-85. 2007
    ..The etiology of the syndrome and metabolic characteristics remain incompletely understood. Recent studies suggest that levels of incretin hormones are increased after GB and may promote excessive beta-cell function and/or growth...
  4. pmc The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes
    Francesco Rubino
    IRCAD European Institute of Telesurgery, University Louis Pasteur, Strasbourg, France
    Ann Surg 244:741-9. 2006
    ..We sought to distinguish between these two mechanisms...
  5. ncbi A leptin missense mutation associated with hypogonadism and morbid obesity
    A Strobel
    Nat Genet 18:213-5. 1998
  6. ncbi Maternal morbid obesity and the risk of adverse pregnancy outcome
    Marie I Cedergren
    Division of Obstetrics and Gynecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Obstet Gynecol 103:219-24. 2004
    ..To evaluate whether morbidly obese women have an increased risk of pregnancy complications and adverse perinatal outcomes...
  7. ncbi Preoperative nutritional status of patients undergoing Roux-en-Y gastric bypass for morbid obesity
    Louis Flancbaum
    Department of Surgery, St Luke s Roosevelt Hospital Center, New York, NY 11542, USA
    J Gastrointest Surg 10:1033-7. 2006
    ..2% Hispanics; P < 0.005). Nutritional deficiencies are common in patients undergoing Roux-en-Y gastric bypass, and these deficiencies should be detected and corrected early to avoid postoperative complications...
  8. pmc Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding
    Judith Korner
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Surg Obes Relat Dis 3:597-601. 2007
    ....
  9. doi A review of laparoscopic sleeve gastrectomy for morbid obesity
    Xinzhe Shi
    Centre for Advancement of Minimally Invasive Surgery CAMIS, Royal Alexandra Hospital, 10240 Kingsway Ave, Edmonton, AB T5H 3V9, Canada
    Obes Surg 20:1171-7. 2010
    Laparoscopic sleeve gastrectomy (LSG) is an innovative approach to the surgical management of morbid obesity. Weight loss may be achieved by restrictive and endocrine mechanisms...
  10. ncbi A 10-year experience with laparoscopic gastric banding for morbid obesity: high long-term complication and failure rates
    M Suter
    Department of Surgery, Hopital du Chablais, Aigle Monthey, Switzerland
    Obes Surg 16:829-35. 2006
    ..and morbidity, laparoscopic gastric banding (LGB) has been considered by many as the treatment of choice for morbid obesity. Few long-term studies have been published...
  11. doi Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism?
    Mario Rotondi
    Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri IRCCS, ISPESL Laboratory for Endocrine Disruptors, Chair of Endocrinology, University of Pavia, Pavia, Italy
    Eur J Endocrinol 160:403-8. 2009
    b>Morbid obesity (body mass index (BMI)> or =40 kg/m(2)) is associated with thyroid function disturbances, with a high rate of subclinical hypothyroidism (SH) being the most consistently reported...
  12. ncbi The Magenstrasse and Mill operation for morbid obesity
    David Johnston
    The Academic Department of Surgery, Leeds General Infirmary and the University of Leeds, Leeds, England, UK
    Obes Surg 13:10-6. 2003
    ..Normal antral grinding of solid food and antro-pyloro-duodenal regulation of gastric emptying and secretion are preserved...
  13. doi Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Int J Obes (Lond) 33:1001-6. 2009
    ....
  14. ncbi The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid E 28034, Spain
    J Clin Endocrinol Metab 90:6364-9. 2005
    The polycystic ovary syndrome (PCOS) is frequently associated with obesity. However, there are very few data about PCOS in morbid obesity, especially with regard to its evolution after bariatric surgery.
  15. pmc Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity
    Adeline Bertola
    Institut National de la Sante et de la Recherche Medicale, U895, Team 8, Hepatic Complications in Obesity, Nice, France
    Diabetes 58:125-33. 2009
    ..We aimed to determine the expression pattern of OPN and its receptor CD44 in obese patients and mice according to insulin resistance and liver steatosis...
  16. ncbi Morbid obesity and tracheal intubation
    Jay B Brodsky
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94303, USA
    Anesth Analg 94:732-6; table of contents. 2002
    ..We conclude that obesity alone is not predictive of tracheal intubation difficulties...
  17. ncbi Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity
    M C Alessi
    Laboratoire d Hématologie Faculté de Médecine Timone, Centre Hospitalier Universitaire Timone, Marseille, France
    Diabetes 49:1374-80. 2000
    ..This increased PAI-1 expression could be the result of tissue cytokine disturbances, such as elevated TGF-beta1 expression...
  18. ncbi Anesthetic considerations for bariatric surgery
    Babatunde O Ogunnaike
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Anesth Analg 95:1793-805. 2002
  19. ncbi Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
    Soumeya Bekri
    Laboratoire d Hépato Gastroentérologie, EA1186, Faculté Médecine de Nice, Nice, France
    Gastroenterology 131:788-96. 2006
    ..We have investigated the possible involvement of hepcidin in massive obesity, a state of chronic low-grade inflammation. Three groups of severely obese patients with or without diabetes or nonalcoholic steatohepatitis were investigated...
  20. ncbi Results of laparoscopic sleeve gastrectomy (LSG) at 1 year in morbidly obese Korean patients
    Sang Moon Han
    Department of Surgery, Kangnam CHA Hospital, School of Medicine, Pochon CHA University, Seoul, South Korea
    Obes Surg 15:1469-75. 2005
    ..Therefore, the treatment plan should be differentiated, and the surgery for morbid obesity should be carefully chosen...
  21. doi Short- and mid-term outcomes of sleeve gastrectomy for morbid obesity: the experience of the Spanish National Registry
    Raquel Sanchez-Santos
    Servicio de Cirugía General y Digestiva, Complejo Hospitalario de Pontevedra, C Mourente s n, Pontevedra 36021, Spain
    Obes Surg 19:1203-10. 2009
    ..However, mid- and long-term results are still unknown. A National Registry has been created in Spain to achieve information on the outcomes of this bariatric procedure...
  22. pmc The physiologic effects of pneumoperitoneum in the morbidly obese
    Ninh T Nguyen
    Department of Surgery, University of California, Irvine, Medical Center, Orange, CA 92868, USA
    Ann Surg 241:219-26. 2005
    ..To review the physiologic effects of carbon dioxide (CO2) pneumoperitoneum in the morbidly obese...
  23. doi Comprehensive interview assessment of eating behavior 18-35 months after gastric bypass surgery for morbid obesity
    Martina de Zwaan
    Department of Psychosomatic Medicine and Psychotherapy, University Hospital of Erlangen, Erlangen, Germany
    Surg Obes Relat Dis 6:79-85. 2010
    ....
  24. ncbi Fatal pulmonary embolism after bariatric operations for morbid obesity: a 24-year retrospective analysis
    James A Sapala
    Department of Surgery, Harper University Hospital, Detroit Medical Center and Wayne State University School of Medicine, Detroit, MI, USA
    Obes Surg 13:819-25. 2003
    Pulmonary embolism (PE) is a leading cause of death following gastric bypass operations for morbid obesity. Although its incidence appears to be stable, the number of bariatric operations performed annually is increasing considerably; ..
  25. ncbi Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery
    Caterina Guidone
    Dipartimento di Medicina Interna, Catholic University, Largo A Gemelli, 8, 00168 Rome, Italy
    Diabetes 55:2025-31. 2006
    ..2 diabetes after bariatric surgery, which was reported as an additional benefit of the surgical treatment for morbid obesity. With this question in mind, insulin sensitivity, using euglycemic-hyperinsulinemic clamp, and insulin ..
  26. ncbi Laparoscopic sleeve gastrectomy for morbid obesity: a review
    Sandeep Aggarwal
    Division of Laparoscopic Surgery, Department of Surgery, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Surg Obes Relat Dis 3:189-94. 2007
  27. ncbi [Surgery for morbid obesity: 2. Complications. Results of a Technologic Evaluation by the ANAES]
    S Msika
    Service de Chirurgie Generale et Digestive, Hopital Louis Mourier Colombes
    J Chir (Paris) 140:4-21. 2003
    ..has increased markedly in France in recent years, partly due to a better appreciation of the problem of morbid obesity but also due to the commercial introduction of adjustable gastric banding devices which can be placed by ..
  28. doi Outcomes of sleeve gastrectomy for morbid obesity: a safe and effective procedure?
    Jon Armstrong
    Department of General Surgery, Royal Perth Hospital, 6 10 McCourt St, West Leederville, Perth, WA 6007, Australia
    Int J Surg 8:69-71. 2010
    Sleeve gastrectomy is being performed with increasing frequency in Australia for the treatment of morbid obesity. The aims of this study were to show that sleeve gastrectomy can be performed safely with a low rate of complications and ..
  29. ncbi The learning curve for laparoscopic Roux-en-Y gastric bypass is 100 cases
    P Schauer
    Department of Surgery, The Minimally Invasive Surgery Center, University of Pittsburgh, Presbyterian University Hospital, C 800, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Surg Endosc 17:212-5. 2003
    ..The purpose of this study was to determine the effect of operative experience on perioperative outcomes for laparoscopic Roux-en-Y gastric bypass (LGB)...
  30. doi Type 2 diabetes mellitus and the metabolic syndrome following sleeve gastrectomy in severely obese subjects
    J Vidal
    Obesity Unit, Hospital Clinic Universitari, Villarroel 170, Barcelona, Spain
    Obes Surg 18:1077-82. 2008
    ..Data on the effectiveness of sleeve gastrectomy in improving or resolving type 2 diabetes mellitus (T2DM) and the metabolic syndrome (MS) are scarce...
  31. ncbi Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics
    Roger E Hofer
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Can J Anaesth 52:176-80. 2005
    ..To describe the anesthetic management of a patient with extreme obesity undergoing bariatric surgery whose intraoperative narcotic management was entirely substituted with dexmedetomidine...
  32. doi High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosis
    Jean Marc Sabate
    Service d Hepato Gastroenterologie, AP HP, Hopital Louis Mourier, Universite Paris 7, 92700 Colombes, France
    Obes Surg 18:371-7. 2008
    ..Small intestinal bacterial overgrowth (SIBO) could be related to NAFLD. Our aim was to determine the prevalence of SIBO and its relationship with liver lesions in morbidly obese patients...
  33. ncbi Port complications following laparoscopic adjustable gastric banding for morbid obesity
    Andrei Keidar
    Department of Surgery B, Sourasky Medical Center, Tel Aviv, Israel
    Obes Surg 15:361-5. 2005
    ..Port complications are considered to be minor; however, few studies have analyzed them, and the optimal technique of port implantation and management has not been elucidated...
  34. ncbi Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    Raffaella Cancello
    INSERM Avenir, Paris 6 University EA3502 and Human Research Center on Nutrition CRNH, Hotel Dieu Hospital, AP HP, Paris, France
    Diabetes 54:2277-86. 2005
    ..We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT...
  35. ncbi Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding
    M V Heinonen
    Department of Biotechnology Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, 70211 Kuopio, Finland
    Regul Pept 130:7-13. 2005
    ..In addition, we measured in a subgroup of these patients in the same individual orexin-A and leptin plasma levels one year after gastric banding surgery...
  36. ncbi Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome
    K Zwirska-Korczala
    Department of Physiology, Zabrze, Medical University of Silesia, Katowice, Poland
    J Physiol Pharmacol 58:13-35. 2007
    ....
  37. ncbi Lap-Band erosion: incidence and treatment
    E Niville
    Department of Abdominal Surgery, Ziekenhuis Oost Limburg, Genk, Belgium
    Obes Surg 11:744-7. 2001
    Laparoscopic adjustable gastric banding (LAGB) is an effective and safe surgical treatment for morbid obesity. Migration of the band through the stomach wall is a well-known late complication that may jeopardize the aim of the treatment--..
  38. ncbi The laparoscopic adjustable gastric band (Lap-Band): a prospective study of medium-term effects on weight, health and quality of life
    Paul E O'Brien
    Monash Department of Surgery, Alfred Hospital, Melbourne 3181, Australia
    Obes Surg 12:652-60. 2002
    ..Obesity is now one of our major public health problems. Effective and acceptable treatment options are needed. The Lap-Band system is placed laparoscopically and allows adjustment of the level of gastric restriction...
  39. doi Diagnosis and management of gastric leaks after laparoscopic sleeve gastrectomy for morbid obesity
    Jeremy T Tan
    Department of General Surgery, Sir Charles Gairdner Hospital, Hospital Ave, Western Australia, Australia
    Obes Surg 20:403-9. 2010
    ..LSG) is increasingly being recognised as a valid stand-alone procedure for the surgical management of morbid obesity. The leak rate from the gastric staple line ranges from 1.4% to 20%...
  40. ncbi Early experience with two-stage laparoscopic Roux-en-Y gastric bypass as an alternative in the super-super obese patient
    J P Regan
    Division of Laparoscopic Surgery, Department of Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1103, New York, NY, USA
    Obes Surg 13:861-4. 2003
    ..Current limited experience exists with a two-stage biliopancreatic diversion and duodenal switch in the supersuper obese patient, and we now present our early experience with a two-stage gastric bypass for these patients...
  41. doi Complications after sleeve gastrectomy for morbid obesity
    Eldo E Frezza
    Department of Surgery, The University of Alabama at Birmingham, 700 South 19th Street, VAMC 112, Birmingham, AL 35233, USA
    Obes Surg 19:684-7. 2009
    ..Laparoscopic sleeve gastrectomy (LSG) is an increasingly used bariatric surgical procedure...
  42. doi Results of laparoscopic sleeve gastrectomy: a prospective study in 135 patients with morbid obesity
    David Fuks
    Federation of Digestive Diseases, Amiens North Hospital, University of Picardy, Amiens, France
    Surgery 145:106-13. 2009
    Sleeve gastrectomy is a new restrictive bariatric procedure increasingly indicated in the treatment of morbid obesity. The authors report their experience of laparoscopic sleeve gastrectomy (LSG), evaluate the efficacy of this procedure ..
  43. ncbi Laparoscopic sleeve gastrectomy: a multi-purpose bariatric operation
    Aniceto Baltasar
    Clínica San Jorge and Alcoy Hospital, Chief of the Surgical Service, Alcoy, Spain
    Obes Surg 15:1124-8. 2005
    ..The use of the laparoscopic sleeve gastrectomy (LSG), a restrictive operation, in different settings, is presented...
  44. ncbi Effectiveness of laparoscopic sleeve gastrectomy (first stage of biliopancreatic diversion with duodenal switch) on co-morbidities in super-obese high-risk patients
    Gianfranco Silecchia
    Department of Surgery P Stefanini, University La Sapienza of Rome, Rome, Italy
    Obes Surg 16:1138-44. 2006
    ....
  45. ncbi Meta-analysis: surgical treatment of obesity
    Melinda A Maggard
    Southern California Evidence Based Practice Center, RAND Health Division, Santa Monica, California, USA
    Ann Intern Med 142:547-59. 2005
    ..Controversy exists regarding the effectiveness of surgery for weight loss and the resulting improvement in health-related outcomes...
  46. pmc Potential of surgery for curing type 2 diabetes mellitus
    Francesco Rubino
    IRCAD European Institute of Telesurgery, Strasbourg, France
    Ann Surg 236:554-9. 2002
    To review the effect of morbid obesity surgery on type 2 diabetes mellitus, and to analyze data that might explain the mechanisms of action of these surgeries and that could answer the question of whether surgery for morbid obesity can ..
  47. ncbi Effect of prepregnancy body mass index categories on obstetrical and neonatal outcomes
    Haim A Abenhaim
    Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital, Women s Pavillion, 687 Ave des Pins Ouest, F4 46, Montreal, QC, Canada, PQ H3A 1A1
    Arch Gynecol Obstet 275:39-43. 2007
    ..To examine the association between body mass index (BMI) and obstetrical and neonatal outcomes...
  48. doi Vitamin D, PTH, and the metabolic syndrome in severely obese subjects
    Sergio Rueda
    Obesity Unit, Hospital Clinic Universitari, Villarroel 170, 08036 Barcelona, Spain
    Obes Surg 18:151-4. 2008
    ..The objective of this study was to evaluate the association between the metabolic syndrome (MS) and vitamin D [25(OH)D] or parathyroid hormone (PTH) levels in severely obese subjects...
  49. ncbi Clinical and cost effectiveness of surgery for morbid obesity: a systematic review and economic evaluation
    A Clegg
    Southampton Health Technology Assessments Centre SHTAC, Wessex Institute for Health Research and Development, University of Southampton, Southampton, UK
    Int J Obes Relat Metab Disord 27:1167-77. 2003
    To assess the clinical and cost effectiveness of surgery for people with morbid obesity.
  50. pmc Laparoscopic Roux-en-Y versus mini-gastric bypass for the treatment of morbid obesity: a prospective randomized controlled clinical trial
    Wei Jei Lee
    Department of Surgery, En Chu Kong Hospital and School of Nursing, Taiwan
    Ann Surg 242:20-8. 2005
    This prospective, randomized trial compared the safety and effectiveness of laparoscopic Roux-en-Y gastric bypass (LRYGBP) and laparoscopic mini-gastric bypass (LMGBP) in the treatment of morbid obesity.
  51. ncbi Weight loss maintenance in severely obese adults after an intensive lifestyle intervention: 2- to 4-year follow-up
    Tore Christiansen
    Department of Medicine and Endocrinology C, Aarhus Sygehus, Aarhus University Hospital, Tage Hansensgade 2, DK 8000 Aarhus C, Denmark
    Obesity (Silver Spring) 15:413-20. 2007
    ..To evaluate the long-term weight loss maintenance after 2 to 4 years in severely obese subjects after a lifestyle intervention at a weight loss camp in Denmark...
  52. doi Symmetrical pouch dilatation after laparoscopic adjustable gastric banding: incidence and management
    Wendy A Brown
    Centre for Obesity Research and Education, Monash University, Melbourne, Australia
    Obes Surg 18:1104-8. 2008
    ..Since popularization of the pars flaccida approach and improved anterior fixation, it is our impression that the problem of symmetrical dilatation of the proximal gastric pouch has become more important...
  53. ncbi Review: long-term impact of bariatric surgery on body weight, comorbidities, and nutritional status
    Meena Shah
    Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9052, USA
    J Clin Endocrinol Metab 91:4223-31. 2006
    ....
  54. ncbi Trends in bariatric surgical procedures
    Heena P Santry
    Department of Surgery, University of Chicago, Chicago, Ill, USA
    JAMA 294:1909-17. 2005
    The increasing prevalence and associated sociodemographic disparities of morbid obesity are serious public health concerns...
  55. doi The impact of morbid obesity on patient outcomes after total knee arthroplasty
    Vaishnav Rajgopal
    Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Arthroplasty 23:795-800. 2008
    ..05), they showed greater improvement in function compared with non-morbidly obese patients. Morbid obesity does not affect 1-year outcomes in patients who have had a total knee arthroplasty.
  56. ncbi Treatment of morbid obesity with the Transcend Implantable Gastric Stimulator (IGS): a prospective survey
    Franco Favretti
    Department of Medical and Surgical Sciences, University of Padua, Italy
    Obes Surg 14:666-70. 2004
    ..The implantable gastric stimulator (IGS), a pacemaker-like device, has been found to be safe and effective to induce and maintain weight loss. We present our experience with 20 morbidly obese patients...
  57. ncbi Result of a national audit of bariatric surgery performed at academic centers: a 2004 University HealthSystem Consortium Benchmarking Project
    Ninh T Nguyen
    Department of Surgery, University of California Irvine Medical Center, Orange 92868, USA
    Arch Surg 141:445-9; discussion 449-50. 2006
    ..Bariatric surgery performed at US academic centers is safe and associated with low mortality...
  58. pmc The relationship between hospital volume and outcome in bariatric surgery at academic medical centers
    Ninh T Nguyen
    Department of Surgery, University of California, Irvine, Medical Center, Orange, CA, USA
    Ann Surg 240:586-93; discussion 593-4. 2004
    ..To examine the effect of hospital volume of bariatric surgery on morbidity, mortality, and costs at academic centers...
  59. ncbi Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgery
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Surg Obes Relat Dis 1:358-68. 2005
  60. ncbi Association of morbid obesity and weight change over time with cardiovascular survival in hemodialysis population
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 46:489-500. 2005
    ..However, the association between changes in weight over time and prospective mortality is not known...
  61. ncbi Effect of surgically-induced weight loss on leukocyte indicators of chronic inflammation in morbid obesity
    D R Cottam
    Nassau University Medical Center, New York, USA
    Obes Surg 12:335-42. 2002
    Recent evidence suggests that morbid obesity is a chronic inflammatory condition that may be associated with immune dysfunction...
  62. doi Morbid obesity and inflammation: a prospective study after adjustable gastric banding surgery
    Renata Ramalho
    Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4202, Porto, Portugal
    Obes Surg 19:915-20. 2009
    ..Inflammatory status underlying obesity seems to be implicated in several aspects of metabolic syndrome...
  63. ncbi Morbid obesity in the medical ICU
    A El-Solh
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, James P Nolan Clinical Research Center, University at Buffalo School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
    Chest 120:1989-97. 2001
    ..To describe the clinical course, complications, and prognostic factors of morbidly obese patients admitted to the ICU compared to a control group of nonobese patients...
  64. ncbi Laparoscopic adjustable gastric banding for the treatment of morbid (grade 3) obesity and its metabolic complications: a three-year study
    Antonio E Pontiroli
    Universita degli Studi di Milano, Cattedra di Medicina Interna, Italy
    J Clin Endocrinol Metab 87:3555-61. 2002
    ....
  65. ncbi National variations in morbid obesity and bariatric surgery use
    Benjamin K Poulose
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Am Coll Surg 201:77-84. 2005
    Exploring bariatric surgery use provides data on effective treatment allocation. This study analyzed national rates of bariatric surgery use and the burden of morbid obesity by gender, census region, and age.
  66. ncbi Bariatric surgery and long-term control of morbid obesity
    Robert E Brolin
    Bariatric Surgery, Saint Peter s University Hospital, 254 Easton Ave, New Brunswick, NJ 08903, USA
    JAMA 288:2793-6. 2002
  67. doi Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns
    Kaisa Valli-Jaakola
    Department of Medicine and Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland
    Obesity (Silver Spring) 16:2113-9. 2008
    ..haplotype composed of SNPs rs1800949 and rs943003 showed suggestive evidence for association with adult-onset morbid obesity in Finns...
  68. ncbi Child and parental self-monitoring as determinants of success in the treatment of morbid obesity in low-income minority children
    Julie N Germann
    La Rabida Children s Hospital, E 65th St at Lake Michigan, Chicago, Illinois 60649, USA
    J Pediatr Psychol 32:111-21. 2007
    To examine self-monitoring by children and parents as related to weight control over 6 months within a long-term multidisciplinary program for low-income minority children with morbid obesity.
  69. doi Effects of weight loss after bariatric surgery for morbid obesity on vascular endothelial growth factor-A, adipocytokines, and insulin
    Nuria García de la Torre
    Department of Endocrinology, Hospital Clinico Universitario San Carlos, Martin Lagos s n, 28040 Madrid, Spain
    J Clin Endocrinol Metab 93:4276-81. 2008
    ..Some adipocytokines and hormones also have an effect on vascular development...
  70. doi Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormalities
    Merce Miranda
    Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, IISPV, 43007 Tarragona, Spain
    Metabolism 58:1762-8. 2009
    ..AQP7 and hepatic AQP9 messenger RNA expression and the presence of glucose abnormalities simultaneously in morbid obesity. Adipose tissue (subcutaneous [SAT] and visceral [VAT]) and liver biopsies from the same patient were obtained ..
  71. ncbi Thyroid function in humans with morbid obesity
    Marina A Michalaki
    Division of Endocrinology, Department of Medicine, University Hospital, Patras, Greece
    Thyroid 16:73-8. 2006
    ..5%). The morbidly obese subjects have higher levels of T3, FT3, T4, and TSH, probably the result of the reset of their central thyrostat at higher level...
  72. ncbi Endoscopic and histologic findings of the foregut in 426 patients with morbid obesity
    Attila Csendes
    Department of Surgery and Pathology, University Hospital, Santiago, Chile
    Obes Surg 17:28-34. 2007
    ..In this operation, the distal bypassed stomach is left in situ. We studied pre-operative clinical, endoscopic and histologic findings in a consecutive group of morbidly obese patients prior to bariatric surgery...
  73. doi Mid-term follow-up after sleeve gastrectomy as a final approach for morbid obesity
    Enrique Arias
    The Bariatric and Metabolic Institute, Section of Minimally Invasive and Endoscopic Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA
    Obes Surg 19:544-8. 2009
    In previous publications, we demonstrated the safety and short-term efficacy of laparoscopic sleeve gastrectomy (LSG) as a final step in the treatment of morbid obesity (MO). This study aimed to assess the mid-term efficacy of LSG.
  74. doi An overview of the management of morbid obesity
    S J W Monkhouse
    Department of Surgery, Southmead Hospital, Bristol BS10 5NB, UK
    Postgrad Med J 85:678-81. 2009
    ..Prevention must be at the heart of any strategy to manage obesity, but, for established cases, surgery is taking centre stage and will continue to flourish as new techniques and procedures are developed...
  75. ncbi Laparoscopic total gastric vertical plication in morbid obesity
    Mohammad Talebpour
    Laparoscopic Surgical Ward, Sina Hospital, Tehran Medical University, Tehran, Iran
    J Laparoendosc Adv Surg Tech A 17:793-8. 2007
    ..It has the same result of weight loss as others with minimal risk of complication and very low cost, especially in developing countries...
  76. ncbi Gastric pouch carcinoma after gastric bypass for morbid obesity
    M Toledano Trincado
    Department of General Surgery, Medina del Campo Hospital Valladolid, Spain
    Obes Surg 15:1215-7. 2005
    ..5 years after, gastric carcinoma was discovered in the gastric pouch. Because of varied symptoms following bariatric surgery, patients may not present promptly with symptoms related to a gastric carcinoma...
  77. ncbi Laparoscopic duodenal switch for morbid obesity
    Michel Gagner
    New York Presbyterian Hospital, Department of Surgery, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    Expert Rev Med Devices 3:105-12. 2006
    ..5%, and operative times close to 200 min. Laparoscopic duodenal switch is likely to increase in popularly for the treatment of morbid obesity, especially with the recent advent of laparoscopic sleeve gastrectomy for higher-risk patients.
  78. ncbi Insurance-mandated preoperative dietary counseling does not improve outcome and increases dropout rates in patients considering gastric bypass surgery for morbid obesity
    Mohammad K Jamal
    Department of Surgery, Division of Minimally Invasive Surgery, Virginia Commonwealth University Health System, Richmond, Virginia, USA
    Surg Obes Relat Dis 2:122-7. 2006
    ..We compared outcomes of GBP patients undergoing a mandatory 13 weeks of PDC (n = 72) to a contemporaneous group of patients with no such requirement (no-PDC; n = 252) who underwent operation between January 2000 and December 2002...
  79. ncbi Effect of circulatory congestion on the components of pulmonary diffusing capacity in morbid obesity
    Beno W Oppenheimer
    Division of Pulmonary and Critical Care Medicine and Bellevue Hospital Chest Service, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Obesity (Silver Spring) 14:1172-80. 2006
    ..We examined DLCO and its partition into Vc and Dm in 13 severely obese subjects (BMI = 51 +/- 14 kg/m2) without manifest cardiopulmonary disease before and after surgically induced weight loss...
  80. ncbi Minimally invasive surgery for morbid obesity
    Fredrick Brody
    The George Washington University Medical Center, Department of Surgery, Washington, DC 20037, USA
    Cleve Clin J Med 71:289, 293, 296-8. 2004
    In patients with morbid obesity, surgery is the only treatment known to produce sustained weight loss and to reduce comorbidities...
  81. ncbi Laryngoscopy and morbid obesity: a comparison of the "sniff" and "ramped" positions
    Jeremy S Collins
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA
    Obes Surg 14:1171-5. 2004
    ..The effect of patient position on the view obtained during laryngoscopy was investigated...
  82. pmc Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity
    Negin Behazin
    Dept of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:212-8. 2010
    ..High P(Es) suggests high P(Pl) in such individuals. Lung and respiratory system compliances are low because of breathing at abnormally low lung volumes...
  83. ncbi Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity
    K Clement
    Centre National de la Recherche Scientifique, Unité CNRS EP10, Institut Pasteur, Lille, France
    N Engl J Med 333:352-4. 1995
    ..The potential relevance of this receptor to obesity in humans led us to screen obese French patients for a recently identified mutation in the gene for the receptor...
  84. doi Impact of morbid obesity on chewing ability
    J L Veyrune
    Univ Clermont1, EA 3847, Faculté d Odontologie, 11bvd Charles de Gaulle, 63000, Clermont Ferrand, France
    Obes Surg 18:1467-72. 2008
    ..This study compared the chewing parameters in a group of obese adult patients scheduled for gastric bypass surgery with those of a control group...
  85. ncbi Changes in liver histology accompanying massive weight loss after gastroplasty for morbid obesity
    Charalabos Stratopoulos
    First Department of Surgery and Transplant Center, Evagelismos Hospital of Athens, Greece
    Obes Surg 15:1154-60. 2005
    Nonalcoholic steatohepatitis (NASH) is common in morbid obesity. Our goal was to evaluate the alterations in liver histology and biochemistry before and after weight loss in 51 morbidly obese patients following Mason's vertical banded ..
  86. ncbi Binge eating disorder in extreme obesity
    L K G Hsu
    Department of Psychiatry, New England Medical Center, Boston, Massachusetts 02111, USA
    Int J Obes Relat Metab Disord 26:1398-403. 2002
    ....
  87. pmc Surgery for morbid obesity
    John M H Bennett
    Department of Upper Gastrointestinal Surgery, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK
    Postgrad Med J 83:8-15. 2007
    The prevalence of morbid obesity in the UK population is rising, bringing with it increased levels of cardiovascular disease, diabetes, arthritis and early mortality...
  88. ncbi Depression in association with severe obesity: changes with weight loss
    John B Dixon
    Department of Surgery, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Arch Intern Med 163:2058-65. 2003
    ..The relationship between depression and severe obesity is unclear. We examined depression before and after surgically induced weight loss...
  89. ncbi Physiologic correlates of dyspnea in patients with morbid obesity
    F Collet
    Lung Function Department, Calmette Hospital, Lille University, France
    Int J Obes (Lond) 31:700-6. 2007
    ..This study was undertaken to determine the relationships between dyspnea and pulmonary function including inspiratory muscle endurance (IME) in morbidly obese patients before bariatric surgery...
  90. doi Deep brain stimulation compared with bariatric surgery for the treatment of morbid obesity: a decision analysis study
    Jared M Pisapia
    Department of Neurosurgery, Center for Weight and Eating Disorders, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    Neurosurg Focus 29:E15. 2010
    Roux-en-Y gastric bypass is the gold standard treatment for morbid obesity, although failure rates may be high, particularly in patients with a BMI > 50 kg/m(2)...
  91. ncbi Psychosocial consequences of weight loss following gastric banding for morbid obesity
    J F Kinzl
    Department of Psychiatry, Innsbruck University Hospital, Innsbruck, Austria
    Obes Surg 13:105-10. 2003
    This study was performed to determine what consequences surgery for morbid obesity has on weight loss, problems in eating behavior, quality of life, physical appearance and mental state.
  92. ncbi Effect of gastric bypass on Barrett's esophagus and intestinal metaplasia of the cardia in patients with morbid obesity
    Attila Csendes
    Department of Surgery, Clinical Hospital University of Chile, Santos Dumont 999, Santiago, Chile
    J Gastrointest Surg 10:259-64. 2006
    Gastric bypass in patients with morbid obesity should be an excellent antireflux procedure, because no acid is produced at the small gastric pouch and no duodenal reflux is present, due to the long Roux-en-Y limb...
  93. ncbi Gender variations of body composition, muscle strength and power output in morbid obesity
    C L Lafortuna
    Istituto di Bioimmagini e Fisiologia Molecolari del Consiglio Nazionale delle Ricerche, Segrate, Milano, Italy
    Int J Obes (Lond) 29:833-41. 2005
    ..Motor capabilities are reduced in obese (OB) individuals, and this impairment may result also from quantitative variation of muscle mass due to alterations in body composition...
  94. ncbi Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity
    José I Botella-Carretero
    Department of Clinical Nutrition, Hospital Ramon y Cajal, 28034 Madrid, Spain
    Clin Nutr 26:573-80. 2007
    ..However, it is not known whether this possible association of vitamin D deficiency with the metabolic syndrome is still present at very high degrees of obesity, as in morbidly obese patients...
  95. ncbi Sleeve gastrectomy for morbid obesity
    Andrew A Gumbs
    New York Presbyterian Hospital, Division of Laparoscopy, NY, USA
    Obes Surg 17:962-9. 2007
    The rising prevalence of morbid obesity and the increased incidence of super-obese patients (BMI >50 kg/m2) seeking surgical treatments has led to the search for surgical techniques that provide adequate EWL with the least possible ..
  96. pmc Influence of morbid obesity on the single-dose pharmacokinetics of daptomycin
    Manjunath P Pai
    College of Pharmacy, MSC09 5360, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Antimicrob Agents Chemother 51:2741-7. 2007
    ..Further studies of daptomycin pharmacokinetics in morbidly obese patients with acute bacterial infections and impaired renal function are necessary to better predict appropriate dosage intervals...
  97. ncbi Outcome after laparoscopic adjustable gastric banding - 8 years experience
    R Weiner
    Krankhenhaus Sachsenhausen, Frankfurt Center for Minimally Invasive Surgery, Section of Bariatric Surgery, Germany
    Obes Surg 13:427-34. 2003
    Laparoscopic adjustable gastric banding (LAGB) has been our choice operation for morbid obesity since 1994...
  98. ncbi Bariatric surgery for morbid obesity
    Eric J Demaria
    Duke Weight Loss Surgery Center and the Duke Endosurgery Center, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 356:2176-83. 2007
  99. ncbi The biliopancreatic diversion with the duodenal switch: results beyond 10 years
    Douglas S Hess
    Wood County Hospital, Bowling Green, OH, USA
    Obes Surg 15:408-16. 2005
    ..It is our opinion that the BPD/DS should be considered as the gold standard bariatric operation...
  100. ncbi Is it feasible to reach the bypassed stomach after Roux-en-Y gastric bypass for morbid obesity? The use of the double-balloon enteroscope
    P Sakai
    Endoscopy Unit, Dept of Gastroenterology, Sao Paulo University Medical School, Hospital das Clinicas, Sao Paulo, Brazil
    Endoscopy 37:566-9. 2005
    Endoscopic evaluation of the excluded stomach after Roux-en-Y gastric bypass surgery for morbid obesity is a challenge, and the pathological changes that take place in the bypassed stomach are unclear...
  101. doi Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver disease
    José I Botella-Carretero
    Unit of Obesity Surgery, Department of Endocrinology and Nutrition, Hospital Universitario Ramon y Cajal, Carretera de Colmenar Km 9 1, 28034 Madrid, Spain
    Obes Surg 20:69-76. 2010
    ....

Research Grants63

  1. Role of the Omentum in the Treatment of Morbid Obesity
    Naji Abumrad; Fiscal Year: 2009
    ..Parameters will be correlated with time dependent changes in inflammatory markers (e.g. CRP, IL-6, TNF-a2R, etc.) and with tissue insulin responsiveness using hyperinsulinemic euglycemic clamps. ..
  2. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..Chronically increased food intake contributes to morbid obesity, chronically decreased food intake contributes to cachectic wasting as severe complication in overwhelming ..
  3. RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue Axis
    Naji N Abumrad; Fiscal Year: 2013
    ..The information derived could lead to the combination of less invasive surgical procedures with pharmacologic manipulation of the levels of acylated ghrelin and/or leptin for the treatment of morbid obesity.
  4. Weight management for improved pregnancy outcomes
    Victor J Stevens; Fiscal Year: 2012
    ..Whereas morbid obesity was once rare among pregnant women, a rapidly increasing proportion of obstetrics patients now have levels of ..
  5. Human Cell-Based Models of Primary Adipocyte Disorders
    CHAD ALBERT COWAN; Fiscal Year: 2013
    ..Interestingly, most of these clinical symptoms are also found in individuals with morbid obesity. While the physiological consequences of LMNA and PLIN1 mutations have been described, very little about the ..
  6. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..of obese individuals (body mass index, BMI >30), but surgical interventions are often needed to treat morbid obesity (clinically severe, BMI >40)...
  7. A randomized trial of bariatric surgery for the treatment of sleep apnea
    Sanjay R Patel; Fiscal Year: 2013
    ..Bariatric surgery has been approved as treatment for OSA in patients with co-morbid obesity and in small case series, appears to produce substantial improvements...
  8. Intestinal satiation in Roux-en-Y gastric bypass rats: brain mechanisms and sex d
    Thomas Alexander Lutz; Fiscal Year: 2013
    ..surgery, in particular Roux-en-Y gastric bypass (RYGB) surgery, is currently the only effective therapy for morbid obesity, which is a grave and growing national health problem...
  9. Role of Human Intestinal Microbiota on Success of Surgical Weight Loss Procedures
    BRUCE EDWARD RITTMANN; Fiscal Year: 2013
    ..Bariatric surgery is currently the only available treatment for morbid obesity that consistently achieves and maintains substantial weight loss, decreases the incidence and severity of ..
  10. Bariatric Surgery for Morbid Obesity: Clinical and Pathophysiologic Consequences
    PAUL DAVID BERK; Fiscal Year: 2010
    ..abstract_text> ..
  11. RNA editing-mediated modulation of serotonin 2C receptor protein expression
    RANDI JO ULBRICHT; Fiscal Year: 2011
    ..cognitive deficits, decreased somatic growth, neonatal muscular hypotonia, and hyperphagia associated with morbid obesity. Interestingly, these mutant mice exhibit an unprecedented 40- to 70-fold increase in 5HT2C receptor density ..
  12. Adiponectin Polymorphisms, Insulin Resistance, and Pharmacokinetics in Obesity
    Jerry Ingrande; Fiscal Year: 2013
    The incidence of morbid obesity has tripled over the last three decades in the developed world. In the United States alone, 65% of the population is overweight or obese...
  13. Understanding the role of bile as a mechanism for improved glucose homeostasis fo
    APRIL DAWN STRADER; Fiscal Year: 2010
    ..Bariatric surgery remains the most effective treatment for morbid obesity. In addition, bariatric surgery such as Roux-en Y Gastric Bypass causes the immediate resolution of type-II ..
  14. Architectural Basis of Leptin Transmembrane Signaling
    Georgios Skiniotis; Fiscal Year: 2013
    ..food intake and stimulates energy expenditure, while functional defects in either leptin or L-R result in morbid obesity, hyperglycemia, decreased insulin sensitivity, and hyperlipidemia...
  15. Role of Sim1 in Hyperphagic Obesity
    Bassil M Kublaoui; Fiscal Year: 2010
    ..We are trying understand how the brain regulates our eating behavior. We study a gene that was found to cause morbid obesity in a girl. We are using a mouse model of this gene to understand how it causes obesity.
  16. Genetic Determinants of Weight Loss and Resolution of Co-Morbidities
    Glenn S Gerhard; Fiscal Year: 2013
    ..b>Morbid obesity (BMI>40 kg/m2), which afflicts over 5% of the U.S...
  17. Gastric bypass surgery alters the regulation of food reward
    Andras Hajnal; Fiscal Year: 2013
    Gastric bypass surgery (GBS) is an exceptionally successful therapy for morbid obesity and type 2 diabetes...
  18. Role of Ileum in Reducing Obesity Related Comorbidities
    Rohit Kohli; Fiscal Year: 2013
    ..States such that bariatric surgery has become an accepted therapeutic option for adults and adolescents with morbid obesity. Bariatric surgery provides significant metabolic benefits, including resolution of type-2 diabetes and marked ..
  19. Rare disease CRC for new therapies and new diagnostics
    ALAN KENNETH PERCY; Fiscal Year: 2013
    ..studies according to genotype, 2) to perform natural history studies on non-PWS individuals with early-onset morbid obesity (EMO) and compare them with PWS, and 3) to develop parameters and tool for clnical trials...
  20. Outcomes of Bariatric Surgery among Patients with Bipolar Disorder
    Ameena T Ahmed; Fiscal Year: 2012
    ..Bariatric surgery is the most effective treatment for morbid obesity. Although BD patients suffer disproportionately from obesity, there is virtually no published data on how ..
  21. Neural Mechanisms Associated with Nicotine Addiction and Obesity Co-Morbidities
    Laura E Martin; Fiscal Year: 2011
    ..is to increase our understanding of how the neural systems of reward differentially respond in the case of co-morbid obesity and nicotine addiction, which will inform smoking cessation and weight management treatment programs designed ..
  22. A TELEHEALTH INNOVATION TO SUPPORT WEIGHT LOSS SURGERY
    VESTA BRUE; Fiscal Year: 2010
    ..S. and an effective treatment for morbid obesity (MO). Close to a quarter-million surgeries are performed annually in the U.S...
  23. Skeletal health in obesity and after bariatric surgery
    ELAINE WEI YIN YU; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Morbid obesity is an important public health problem, but the complex relationship between obesity and the skeleton is poorly understood...
  24. Predicting Phenotypic Trajectories in Prader-Willi Syndrome
    ELISABETH MAY DYKENS; Fiscal Year: 2013
    ..disabilities;compulsivity;tantrums;irritability;growth hormone dysfunction;hyperphagia;and increased risks of morbid obesity, psychosis, and autism spectrum disorders (ASD)...
  25. Gastric Sleeve Magnetic Implant
    Jose Navia; Fiscal Year: 2010
    ..In response, there has been increasing interest in the surgical treatment of morbid obesity with the application of laparoscopic techniques...
  26. MHIRT: Training Grant
    CHARLES L ORTIZ; Fiscal Year: 2013
    ..These include: 1) morbid obesity and related conditions such as diabetes, cardiovascular disease and renal insufficiency;2) early childhood ..
  27. Neuroanatomic Studies in Prader-Willi Syndrome and Early-onset Obesity
    Jennifer L Miller; Fiscal Year: 2012
    ..A group of children with early-onset morbid obesity of unknown origin (EMO) will serve as a comparison group to further evaluate our hypothesis that obesity, ..
  28. Translating Dietary Trials into the Community
    Alain Bertoni; Fiscal Year: 2009
    ..diet and/or a lower BP goal than 140/90, including persons with diabetes, heart failure, renal failure, morbid obesity (BMI>45) or those who are extremely underweight (BMI<18.5)...
  29. Neural-Specific Regulation of POMC Gene Expression
    Malcolm Low; Fiscal Year: 2005
    ..Null mutations of the POMC gene have rarely been associated with early onset morbid obesity and hyperphagia in children...
  30. Leptin in Vascular Disease
    Daniel T Eitzman; Fiscal Year: 2012
    ..Deficiency of hypothalamic leptin receptors or complete deficiency of leptin leads to morbid obesity, therefore therapeutic targeting of all leptin receptors or neutralizing all circulating leptin is not ..
  31. Extended Effects of Bariatric Surgery on Cognitive Function
    John J Gunstad; Fiscal Year: 2010
    ..Bariatric surgery is viewed as an effective intervention for morbid obesity, though its effects on cognition are largely unknown...
  32. Role of the lower gut in the control of energy balance
    HENRY KOOPMANS; Fiscal Year: 2005
    Surgery has been the most successful treatment for morbid obesity. The main objective of this grant proposal is to determine why lower gut signals generated in bypass surgery have been so successful in causing reduced food intake and body ..
  33. 'OB' GENE IN HUMANS
    Robert Considine; Fiscal Year: 2000
    ..Two separate mutations in the mouse ob gene result in the development of morbid obesity. We have sequenced the coding region of the human ob gene and do not detect any mutations in the gene in ..
  34. THERAPEUTIC POTENTIAL OF INTESTINAL PACING FOR OBESITY
    Jiande Chen; Fiscal Year: 2003
    ..However, currently there is no satisfactory therapy for morbid obesity and there is a great need to explore new therapeutic options...
  35. GENERAL CLINICAL RESEARCH CENTER
    Paul Calabresi; Fiscal Year: 1990
    ..metabolism; psychosocial predictors of success and metabolic consequences of gastric bypass surgery in morbid obesity; pharmacokinetics of new antimetabolite regimens for the treatment of psoriasis; the interrelationship of ..
  36. Impact of gastric bypass surgery on risk of CVD in type 2 diabetes mellitus
    Alfonso Torquati; Fiscal Year: 2009
    ..Currently, surgical treatment of morbid obesity, termed bariatric surgery, appears to be the only modality that results in significant and sustained weight ..
  37. LIVER ABNORMALITIES AFTER JEJUNOILEAL BYPASS
    Herbert Greenlee; Fiscal Year: 1980
    The etiology of the hepatic abnormalities observed after jejunoileal bypass (JIBP) for morbid obesity is unknown. Three factors individually or in combination may contribute to hepatic injury and dysfunction...
  38. STRENGTH TRAINING FOLLOWING GASTRIC BYPASS FOR OBESITY
    Allan Geliebter; Fiscal Year: 2004
    ..Roux-en-Y gastric bypass (RYGB) is now the most common operation to treat morbid obesity in the US...
  39. MECHANISMS OF UCP REGULATION BY LEPTIN
    Thomas Gettys; Fiscal Year: 2001
    ..These mice are characterized by morbid obesity, hyperphagia, low sympathetic output, compromised thermogenic capacity and enhanced energy efficiency...
  40. RESEARCH IN PRADER-WILLI SYNDROME AND OBESITY
    Daniel Driscoll; Fiscal Year: 2004
    ..syndrome (especially the gene causing obesity), and to explore the potential role of early childhood morbid obesity plays in mental retardation...
  41. QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    Richard Bergman; Fiscal Year: 2005
    ..and insulin resistance, but with limited increase in body weight which represents central obesity but not morbid obesity. We will measure the flux of FFA and cytokines (leptin, TNF-alpha, IL-6) from the visceral adipose depot to ..
  42. Function and Signaling Mechanisms of Leptin Receptors
    Joyce Repa; Fiscal Year: 2005
    ..Mice and humans with mutation of the gene encoding leptin or its receptor develop morbid obesity. Our long-term objectives are to understand the molecular regulation of mammalian body weight and the ..
  43. LIFESTYLE ACTIVITY FOR WEIGHT MANAGEMENT
    Thomas Wadden; Fiscal Year: 2003
    ..The predicted superiority of lifestyle activity is based on extensive pilot data and, if confirmed, should significantly improve the management of obesity and its associated health complications. ..
  44. Behavioral factors in the surgical treatment of obesity
    Thomas Wadden; Fiscal Year: 2009
    ..The study, by examining ghrelin and other appetite-related hormones, also will enhance knowledge of the regulation of body weight following GBP. ..
  45. BEHAVIOR MODIFICATION AND PHARMACOTHERAPY FOR OBESITY
    Thomas Wadden; Fiscal Year: 2002
    ..If confirmed, the above findings will have important implications for treating obesity in primary care. ..
  46. Economic Analysis of the Impact of Food Advertisements
    John Cawley; Fiscal Year: 2007
    ..Together these data allow us to calculate a precise measure of the advertisements to which each youth was exposed. This will allow us to better estimate how food advertising impacts youth consumption. [unreadable] [unreadable]..
  47. Adolescent Gastric By-Pass and Diabetic Precursors
    Thomas Inge; Fiscal Year: 2006
    ....
  48. Changes in sexual function following bariatric surgery
    DAVID SARWER; Fiscal Year: 2009
    ..The proposed study is innovative, as it will provide new and important information on the long-term effects of bariatric surgery on these important areas of quality of life. ..
  49. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..Leibel and Dr. Wardlaw, are experienced in basic and clinical research. They are easily accessible, enthusiastic about my projects, and will facilitate my transition to status as an independent investigator. ..
  50. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..abstract_text> ..
  51. Obesity, Body Image and Weight Maintenance
    DAVID SARWER; Fiscal Year: 2005
    ..These studies have been selected to further develop my knowledge of the treatment of obesity, and the training program has been designed to facilitate my development as an independent investigator in the field of obesity. ..
  52. Postoperative dietary counseling after bariatric surgery
    DAVID SARWER; Fiscal Year: 2005
    ..Results of this study could have a significant impact on the postoperative care of these individuals. ..
  53. ENTERIC PHYSIOLOGY OF THE TRANSPLANTED GUT
    Michael Sarr; Fiscal Year: 2007
    ..This proposal will define important, novel neural mechanisms regulating motor and absorptive function in the denervated gut. Selected aspects have translational value to clinical gut transplantation. [unreadable] [unreadable]..
  54. Insulin resistance in severely obese patients
    Nana Gletsu Miller; Fiscal Year: 2006
    ..Our findings may provide novel mechanisms that link regional obesity and insulin action. ..
  55. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  56. Plasma Proteome Profiling of Insulin Resistance
    Nana Gletsu Miller; Fiscal Year: 2008
    ..Our proposed proteomics analyses are aimed to fill this critical gap in knowledge. [unreadable] [unreadable] [unreadable] [unreadable]..
  57. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. "MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD"
    Allon Friedman; Fiscal Year: 2009
    ..abstract_text> ..
  59. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010
    ....
  60. The Effect of a Probiotic on Hepatic Steatosis
    Steven Solga; Fiscal Year: 2004
    ..If the efficacy of probiotics is established one type of chronic liver disease, the possibility that similar biological therapies might benefit other chronic inflammatory states would merit further evaluation. ..
  61. Alcohol Intake on Insulin Sensitivity and Heart Disease
    Sun Kim; Fiscal Year: 2006
    ..Given the morbidity and mortality of insulin resistance and CVD, it becomes important to clarify the role of moderate alcohol consumption to both. ..