protein deficiency

Summary

Summary: A nutritional condition produced by a deficiency of proteins in the diet, characterized by adaptive enzyme changes in the liver, increase in amino acid synthetases, and diminution of urea formation, thus conserving nitrogen and reducing its loss in the urine. Growth, immune response, repair, and production of enzymes and hormones are all impaired in severe protein deficiency. Protein deficiency may also arise in the face of adequate protein intake if the protein is of poor quality (i.e., the content of one or more amino acids is inadequate and thus becomes the limiting factor in protein utilization). (From Merck Manual, 16th ed; Harrison's Principles of Internal Medicine, 12th ed, p406)

Top Publications

  1. ncbi Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets
    J L Tarry-Adkins
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Level 4, Box 289, Addenbrooke s Treatment Centre, Addenbrooke s Hospital, Hills Rd Cambridge, CB2 OQQ, UK
    FASEB J 23:1521-8. 2009
  2. ncbi Brain glutathione content and glutamate uptake are reduced in rats exposed to pre- and postnatal protein malnutrition
    Ana Maria Feoli
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande de do Sul, Porto Alegre, Brazil
    J Nutr 136:2357-61. 2006
  3. ncbi Prenatal protein malnutrition decreases mossy fibers-CA3 thorny excrescences asymmetrical synapses in adult rats
    Leticia Granados-Rojas
    Division de Medicina Experimental, Instituto Nacional de Pediatría S S, Mexico, D F 04530, Mexico
    Brain Res 933:164-71. 2002
  4. ncbi Different types of nutritional deficiencies affect different domains of spatial memory function checked in a radial arm maze
    S C Ranade
    National Brain Research Centre, National Highway 8, Manesar, Haryana 122050, India
    Neuroscience 152:859-66. 2008
  5. ncbi Cerebral GABA release and GAD activity in protein- and tryptophan-restricted rats during development
    A R Del Angel-Meza
    Division de Neurociencias, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco 44340, Mexico
    Int J Dev Neurosci 20:47-54. 2002
  6. ncbi Dendritic morphology and orientation of pyramidal cells of the neocortex in two groups of early postnatal undernourished-rehabilitated rats
    María Elana Cordero
    Programa de Morfología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, 1027 Independencia Ave, Box 70079, Santiago 7, Chile
    Brain Res Dev Brain Res 142:37-45. 2003
  7. ncbi Modulation of HDL metabolism by probucol in complete cholesteryl ester transfer protein deficiency
    Hiroshi Noto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Atherosclerosis 171:131-6. 2003
  8. pmc Effect of prenatal protein malnutrition on long-term potentiation and BDNF protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization
    Alejandro Hernandez
    Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, 3363 Avenida Alameda Bernardo O Higgins, 9170022 Santiago, Chile
    Neural Plast 2008:646919. 2008
  9. ncbi Prenatal protein malnutrition results in increased frequency of miniature inhibitory postsynaptic currents in rat CA3 interneurons
    Yu Ming Chang
    Center for Behavioral Development and Mental Retardation, M923, Boston University School of Medicine, 85 E Newton Street, Boston, MA 02118, USA
    Nutr Neurosci 6:263-7. 2003
  10. ncbi The mossy fiber system of the hippocampal formation is decreased by chronic and postnatal but not by prenatal protein malnutrition in rats
    Leticia Granados-Rojas
    Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus UNAM UAQ Juriquilla, Queretaro, Qro 76001, Mexico
    Nutr Neurosci 7:301-8. 2004

Detail Information

Publications231 found, 100 shown here

  1. ncbi Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets
    J L Tarry-Adkins
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Level 4, Box 289, Addenbrooke s Treatment Centre, Addenbrooke s Hospital, Hills Rd Cambridge, CB2 OQQ, UK
    FASEB J 23:1521-8. 2009
    ..We conclude that maternal diet influences expression of markers of cellular stress and telomere length in pancreatic islets. This may provide a mechanistic link between early nutrition and growth and type 2 diabetes...
  2. ncbi Brain glutathione content and glutamate uptake are reduced in rats exposed to pre- and postnatal protein malnutrition
    Ana Maria Feoli
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande de do Sul, Porto Alegre, Brazil
    J Nutr 136:2357-61. 2006
    ..Moreover, a recovery of altered metabolic variables may occur during adulthood, despite persistent PMN...
  3. ncbi Prenatal protein malnutrition decreases mossy fibers-CA3 thorny excrescences asymmetrical synapses in adult rats
    Leticia Granados-Rojas
    Division de Medicina Experimental, Instituto Nacional de Pediatría S S, Mexico, D F 04530, Mexico
    Brain Res 933:164-71. 2002
    ..Hence, prenatal protein malnutrition induces long lasting deleterious effects on the progression of developmental programs controlling synaptogenesis and/or synaptic consolidation, likely by affecting a myriad of cellular processes...
  4. ncbi Different types of nutritional deficiencies affect different domains of spatial memory function checked in a radial arm maze
    S C Ranade
    National Brain Research Centre, National Highway 8, Manesar, Haryana 122050, India
    Neuroscience 152:859-66. 2008
    ..Awareness of this should inform prevention strategies in trying to reverse the effects of adverse maternal nutrition during critical periods in brain development...
  5. ncbi Cerebral GABA release and GAD activity in protein- and tryptophan-restricted rats during development
    A R Del Angel-Meza
    Division de Neurociencias, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco 44340, Mexico
    Int J Dev Neurosci 20:47-54. 2002
    ..Taken together, these results may represent a plastic response by GABAergic neurons to (5-HTergic under-stimulation in mainly corn-fed animals...
  6. ncbi Dendritic morphology and orientation of pyramidal cells of the neocortex in two groups of early postnatal undernourished-rehabilitated rats
    María Elana Cordero
    Programa de Morfología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, 1027 Independencia Ave, Box 70079, Santiago 7, Chile
    Brain Res Dev Brain Res 142:37-45. 2003
    ....
  7. ncbi Modulation of HDL metabolism by probucol in complete cholesteryl ester transfer protein deficiency
    Hiroshi Noto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Atherosclerosis 171:131-6. 2003
    ..Probucol treatment in these patients was also associated with protection of lipoproteins against oxidative stress, suggesting a clinical benefit of this drug even in such a state...
  8. pmc Effect of prenatal protein malnutrition on long-term potentiation and BDNF protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization
    Alejandro Hernandez
    Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, 3363 Avenida Alameda Bernardo O Higgins, 9170022 Santiago, Chile
    Neural Plast 2008:646919. 2008
    ....
  9. ncbi Prenatal protein malnutrition results in increased frequency of miniature inhibitory postsynaptic currents in rat CA3 interneurons
    Yu Ming Chang
    Center for Behavioral Development and Mental Retardation, M923, Boston University School of Medicine, 85 E Newton Street, Boston, MA 02118, USA
    Nutr Neurosci 6:263-7. 2003
    ..Thus, while the basic membrane properties of interneurons are preserved, there is a significant increase in the probability of GABA release from interneurons following prenatal protein malnutrition...
  10. ncbi The mossy fiber system of the hippocampal formation is decreased by chronic and postnatal but not by prenatal protein malnutrition in rats
    Leticia Granados-Rojas
    Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus UNAM UAQ Juriquilla, Queretaro, Qro 76001, Mexico
    Nutr Neurosci 7:301-8. 2004
    ....
  11. ncbi Maternal protein deficiency during a gastrointestinal nematode infection alters developmental profile of lymphocyte populations and selected cytokines in neonatal mice
    Maurice R Odiere
    Institute of Parasitology, McGill University Macdonald Campus, Ste Anne de Bellevue, Quebec, Canada
    J Nutr 143:100-7. 2013
    ..We investigated the possibility that maternal protein deficiency (PD) during a chronic gastrointestinal (GI) nematode infection could impair neonatal immune development...
  12. ncbi Prenatal protein deprivation in rats induces changes in prepulse inhibition and NMDA receptor binding
    Abraham A Palmer
    Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
    Brain Res 996:193-201. 2004
    ..This animal model may be useful for the investigation of neurodevelopmental changes that are associated with schizophrenia in humans...
  13. ncbi Involution of thymic epithelium and low serum thymulin bioactivity in weanling mice subjected to severe food intake restriction or severe protein deficiency
    A Mittal
    Department of Nutritional Sciences, College of Biological Science, University of Guelph, Ontario, Canada
    Exp Mol Pathol 48:226-35. 1988
    ..The results reveal thymic epithelial involution in the two most common rodent models of malnutrition, and suggest that this may contribute to the low serum thymulin levels found in malnourished experimental animals and humans...
  14. ncbi Protein deficiency impairs DNA vaccine-induced antigen-specific T cell but not B cell response in C57BL/6 mice
    Tohru Sakai
    Department of International Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School, Kuramnoto 3 18 15, Tokushirna 770 8503, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:376-82. 2006
    ..The aim of this study was to determine the relationship between protein deficiency and DNA vaccine-induced immunoresponses. C57BL/6 mice were fed a 5% or 20% casein diet for 30 d...
  15. ncbi Impact of protein deficiency on venous ulcer healing
    Cécile Legendre
    Service de rééducation vasculaire, Hopital Broussais, APHP, Ivry sur Seine, France
    J Vasc Surg 48:688-93. 2008
    The prevalence of protein deficiency and its impact on wound healing is not known for leg ulcers...
  16. ncbi Perinatal development and adult blood pressure
    N Ashton
    School of Biological Sciences, University of Manchester, Manchester, UK
    Braz J Med Biol Res 33:731-40. 2000
    ..These two models clearly show that adult blood pressure is influenced by exposure to one of a number of stimuli during critical stages of perinatal development...
  17. ncbi Role of brain and peripheral angiotensin II in hypertension and altered arterial baroreflex programmed during fetal life in rat
    Patrick Pladys
    Research Center, Hopital Sainte Justine, Department of Pediatrics, University of Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada, H3T 1C5
    Pediatr Res 55:1042-9. 2004
    ..These data demonstrate a major tonic role of brain and peripheral RAS on hypertension associated with antenatal nutrient deprivation...
  18. ncbi Effects of protein deficiency induced by raw soy with and without sucrose on dentine formation and dentinal caries in young rats
    Sisko Huumonen
    Institute of Dentistry, University of Oulu, P O Box 5281, FIN 90014, Oulu, Finland
    Arch Oral Biol 50:453-9. 2005
    The effects of protein deficiency and sucrose on formation and mineralization of dentine and dental caries in the molars of young rats were investigated.
  19. ncbi Effects of prenatal protein malnutrition on the electrical cerebral activity during development
    V De Frias
    Physiology Department, School of Medicine José Maria Vargas, Central University of Venezuela, Bolivarian Republic of Venezuela
    Neurosci Lett 482:203-7. 2010
    ..The rehabilitation period did not revert the impairment in the electrical cerebral activity produced by malnutrition. We used one-way ANOVA analysis, followed by Tukey test (*p<0.001)...
  20. ncbi Maternal protein deficiency affects mesenchymal stem cell activity in the developing offspring
    Richard O C Oreffo
    University Orthopaedics, Bone and Joint Research Group, University of Southampton, General Hospital, SO16 6YD Southampton, UK
    Bone 33:100-7. 2003
    ..These alterations in mesenchymal stem cell function by the early environment may represent an important candidate mechanism for the programming of osteoporosis and associated consequences in later life...
  21. ncbi Maternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, Bassett Crescent East, Southampton, UK
    Br J Nutr 103:1711-9. 2010
    ..The present findings show that the pattern of induced changes in the adult liver transcriptome were dependent on maternal protein and folic acid intakes during pregnancy...
  22. ncbi Free protein S levels are elevated in familial C4b-binding protein deficiency
    P C Comp
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73104
    Blood 76:2527-9. 1990
    ..A family with hereditary C4b binding protein deficiency has been identified with C4b-binding protein levels in an affected father and daughter of 37 micrograms/mL ..
  23. pmc Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction
    Kusal K Das
    Department of Physiology, Al Ameen Medical College, Bijapur, Karnataka, India
    Environ Health Perspect 110:923-6. 2002
    ..However, these alterations were reversible in both groups of animals fed normal protein diets and protein-restricted diets...
  24. ncbi Morphoquantitative evaluation of the duodenal myenteric neuronal population in rats fed with hypoproteic ration
    Maria Raquel Marçal Natali
    Departamento de Ciências Morfofisiológicas, Universidade Estadual de Maringa, Brasil
    Biocell 29:39-46. 2005
    ..It was concluded that the neuronal and non-neuronal components of the duodenum adjust themselves to the nutritional condition, assuring the maintenance of their functions...
  25. ncbi Orthodontic implications of protein undernutrition in mandibular growth. A cephalometric study in growing rats
    Juan A Garat
    Department of Histology, School of Dentistry, National University of Tucuman, Argentina
    Acta Odontol Latinoam 20:73-8. 2007
    ....
  26. ncbi Low-protein diet impairs vascular relaxation in virgin and pregnant rats
    Angeliki Koumentaki
    Fetal Origins of Adult Disease Research Division, University of Southampton, Obstetrics and Gynaecology 815, Level F, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    Clin Sci (Lond) 102:553-60. 2002
    ..005 respectively). Thus low-protein diets impair vasodilator responses in female rats. These effects may contribute to the poor cardiovascular adaptation to pregnancy and lower fetal weights associated with restricted protein intake...
  27. ncbi Manipulating the sulfur amino acid content of the early diet and its implications for long-term health
    William D Rees
    The Rowett Research Institute, Aberdeen, UK
    Proc Nutr Soc 61:71-7. 2002
    ..The balance between S-adenosyl methionine and the methylated derivatives of folic acid may be critical for the development of differentiating cells and the long-term regulation of gene expression...
  28. ncbi Effect of zinc supplementation on ethanol-mediated bone alterations
    E Gonzalez-Reimers
    Departamento de Medicina Interna, Hospital Universitario, 38320 Tenerife, Canary Islands, Spain
    Food Chem Toxicol 43:1497-505. 2005
    ..24, p<0.001), and also showed a synergistic interaction with protein deficiency (p=0.027). In contrast, no change was observed in hydroxyproline excretion and serum PTH levels...
  29. ncbi Effects of protein deficient diets on the developmental toxicity of inorganic arsenic in mice
    Carol A Lammon
    Capstone College of Nursing, The University of Alabama, Tuscaloosa, Alabama, USA
    Birth Defects Res B Dev Reprod Toxicol 71:124-34. 2004
    ..We sought to determine if dietary protein deficiency affects the developmental toxicity of inorganic arsenic.
  30. pmc The effect of low protein diet in pregnancy on the development of brain metabolism in rat offspring
    E A L Gallagher
    Centre for Developmental Origins of Health and Disease, University of Southampton, 887F Princess Anne Hospital, Hants, UK
    J Physiol 568:553-8. 2005
    ..The effects may form part of a developmental adaptive response to reduce energy consumption and promote perinatal survival, or to confer advantage in a postnatal environment predicted to be nutritionally poor...
  31. ncbi Relationship between protein deficiency in the ration of rats during early ontogeny and function of enzyme systems of digestive and non-digestive organs in adult life
    N M Timofeeva
    I P Pavlov Institute of Physiology, Russian Academy of Sciences, St Petersburg
    Bull Exp Biol Med 138:8-11. 2004
    ..b>Protein deficiency during the early ontogeny modulates functioning of the enzyme systems in digestive and non-digestive organs ..
  32. ncbi [Specificity of activity antioxidative enzymes at protein deficiency and excessive content Cu, Zn, Mn, Se in the food]
    V I Ivakhnenko
    Vopr Pitan 76:11-6. 2007
    ..The analysis of Km and Vmax of Superoxide Dismutase and Glutathione Peroxidase in different alimentary influence may be as one of methods for assessment individualization of diet therapy...
  33. ncbi Nutritional recovery with a soybean flour diet improves the insulin response to a glucose load without modifying glucose homeostasis
    Elisângela de Arruda Oliveira
    Secretaria de Estado de Saúde, Cuiaba, Mato Grasso, Brazil
    Nutrition 24:76-83. 2008
    ..the effect of nutritional recovery with a soybean flour diet on glucose tolerance, insulin response to a glucose load, and the action of insulin in adult rats exposed to a protein deficiency during intrauterine life and lactation.
  34. ncbi Glucose homeostasis in pregnant rats submitted to dietary protein restriction
    Maria Alice Rostom de Mello
    Departamento de Educacao Fisica, IB, UNESP, Rio Claro, SP, Brazil
    Res Commun Mol Pathol Pharmacol 113:229-46. 2003
    ..However, the poor insulin secretion did not fully compensate the high peripheral sensitivity to the hormone, resulting in hypoglycemia...
  35. ncbi Old as mature LOU/c/jall rats enhance protein selection in response to a protein deprivation
    S Boghossian
    Laboratoire de Neuroendocrinologie du Vieillissement, Complexe scientifique des Cezeaux, Universite Blaise Pascal, 24 rue des landais, 63177 Aubiere, Cedex, France
    Exp Gerontol 37:1431-40. 2002
    ..This data supports a decrease in the efficacious utilization of body fuels in old and senescent rats...
  36. ncbi Maternal protein restriction before pregnancy affects vital organs of offspring in Wistar rats
    Sadhana Joshi
    Biometry and Nutrition Group, Agharkar Research Institute, Pune, India
    Metabolism 52:13-8. 2003
    ..The results thus indicate that maternal undernutrition before conception not only affected growth of vital organs, but also resulted in increased levels of glucose and cholesterol in the offspring at adulthood...
  37. ncbi Birthdates and number of neurons in the serotonergic raphe nuclei in the rat with prenatal protein malnutrition
    R S King
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 80 E, Concord Street, Boston, MA 02118, USA
    Nutr Neurosci 5:391-7. 2002
    ....
  38. ncbi Effect of undernutrition on GMP-PNP binding and adenylate cyclase activity from rat brain
    Liane N Rotta
    Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Cell Mol Neurobiol 22:365-72. 2002
    ..This effect was less pronounced or even absent in old rats. 3. Ontogenetically, the dietary treatment effect might be interpreted as a retarded development associated with protein malnutrition...
  39. ncbi Is gastric ulceration different in normal and malnourished rats?
    A C B Paula
    Department of Physiology and Biophysics, State University of Campinas, Campinas, Brazil
    Br J Nutr 93:47-52. 2005
    ..Malnourished rats exhibited resistance to acute gastric lesions, owing to an increase in prostaglandin GE2 release and mucus secretion, which protected their gastric mucosa. This phenomenon was not seen in subchronic gastric ulceration...
  40. ncbi Dietary protein quantity and quality affect rat hepatic gene expression
    Yoshie Endo
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Nutr 132:3632-7. 2002
    ..This study represents a step toward a more global understanding of gene expression changes in states of protein malnutrition...
  41. ncbi Expression of PDX-1 is reduced in pancreatic islets from pups of rat dams fed a low protein diet during gestation and lactation
    Vanessa C Arantes
    Departamento de Fisiologia e Biofísica e, Instituto de Biologia, Universidade Estadual de Campinas, SP, Brasil
    J Nutr 132:3030-5. 2002
    ..The reintroduction of a normal diet early in life restored islet area and cell physiology...
  42. ncbi Effects of pre- and postnatal protein deprivation and postnatal refeeding on myenteric neurons of the rat large intestine: a quantitative morphological study
    Patricia Castelucci
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Brazil
    Cell Tissue Res 310:1-7. 2002
    ..It is concluded that enteric neurons are protected from loss even when there is a substantial reduction in body weight and organ size caused by protein deprivation. The neurons become smaller, but recover size after refeeding...
  43. ncbi Perinatal undernutrition: changes in brain opiate receptor density
    Silvia Kademian
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Ciudad Universitaria Córdoba, Argentina
    Nutr Neurosci 5:53-7. 2002
    ....
  44. ncbi Vasodilation to vascular endothelial growth factor in the uterine artery of the pregnant rat is blunted by low dietary protein intake
    Shigeru Itoh
    Centre for Fetal Origins of Adult Disease, Princess Anne Hospital, University of Southampton, Southampton SO16 5YA, UK
    Pediatr Res 51:485-91. 2002
    ..These results show an attenuated uterine artery vasodilator response to VEGF produced by a low-protein diet in pregnancy, partly because of a reduction of the nitric oxide component of VEGF-mediated relaxation...
  45. ncbi Adult cardiorenal benefits from postnatal fish oil supplement in rat offspring of low-protein pregnancies
    Mariana Catta-Preta
    Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil
    Life Sci 80:219-29. 2006
    ..In conclusion, FO supplement, which is a rich source of n-3 fatty acids (DHA and EPA), has beneficial effects on BP control and cardiac and renal adverse remodeling usually seen in offspring of the LP pregnancies...
  46. ncbi Effects of prenatal protein malnutrition and acute postnatal stress on granule cell genesis in the fascia dentata of neonatal and juvenile rats
    Raymond S King
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA
    Brain Res Dev Brain Res 150:9-15. 2004
    ..Thus, the pattern of neurogenesis in the fascia dentata and its response to stress has been fundamentally altered by prenatal protein deprivation...
  47. ncbi [Functioning of enzymes from digestive and other organs of adult rats depends on the nutrition quality in the early ontogenesis]
    V V Egorova
    Zh Evol Biokhim Fiziol 41:514-9. 2005
  48. ncbi Inadequate intakes of dietary zinc among pregnant women from subsistence households in Sidama, Southern Ethiopia
    Yewelsew Abebe
    College of Agriculture, Hawassa University, Awassa, Ethiopia
    Public Health Nutr 11:379-86. 2008
    ..To assess the prevalence of zinc inadequacy based on dietary intakes and plasma zinc concentrations and, simultaneously, the prevalence of inadequate intakes of energy, protein, calcium and iron...
  49. ncbi Coping strategies and nutritional health in rural Niger: recommendations for consumption of wild plant foods in the Sahel
    Robert S Glew
    Center for Advanced Study of International Development, Michigan State University, East Lansing, Michigan 48823, USA
    Int J Food Sci Nutr 57:314-24. 2006
    ..Comparing local use of various wild plant foods with major nutrition-related health problems including protein deficiency, essential fatty acid deficiency, iron deficiency and iron deficiency anemia, calcium deficiency rickets, ..
  50. ncbi Effects of protein malnutrition on oxidative status in rat brain
    Ana M Feoli
    Departamento de Bioquimica, Programa de Pós Graduação em Ciências Biológicas Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Nutrition 22:160-5. 2006
    ..This study evaluated the effects of protein malnutrition on oxidative status in rat brain areas...
  51. ncbi Early malnourished rats are not affected by anorexia induced by a selective serotonin reuptake inhibitor in adult life
    J M Barreto Medeiros
    Departamento Ciências de la Nutrição, Universidade Federal da Bahia, Salvador, Brazil
    Nutr Neurosci 5:211-4. 2002
    ....
  52. ncbi Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring
    Shobha Rao
    Biometry and Nutrition Unit, Agharkar Research Institute, Pune 411004, India
    Metabolism 55:628-34. 2006
    ..Results suggest that maternal folic acid supplementation at MP intake decreased brain docosahexaenoic acid levels probably involving corticosterone increase...
  53. ncbi Chronic malnutrition does not influence the development of ethylnitrosourea-induced brain tumors
    G Palencia
    Neuroimmunology Laboratory, National Institute of Neurology and Neurosurgery of Mexico, Mexico, DF
    Nutr Neurosci 8:323-5. 2005
    ....
  54. ncbi Leptin and prolactin, but not corticosterone, modulate body weight and thyroid function in protein-malnourished lactating rats
    P C Lisboa
    Dept Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil
    Horm Metab Res 38:295-9. 2006
    ..Thus, we suggest that both leptin and prolactin could play an important role in the body weight and thyroid hormone changes observed in protein-malnourished lactating rats...
  55. ncbi Changes in rat liver cytochromes b, c1, and c and mitochondrial protein in prolonged protein deficiency
    J N Williams
    J Nutr 90:400-4. 1966
  56. ncbi Programming of defective rat pancreatic beta-cell function in offspring from mothers fed a low-protein diet during gestation and the suckling periods
    Wendy E Heywood
    Gastroenterology Unit, Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, UK
    Clin Sci (Lond) 107:37-45. 2004
    ..We studied the effect of protein deficiency during gestation and the suckling period in a rat model and found that poor nutrition 'programmes' ..
  57. ncbi Running inhibits osteoporosis induced by protein-deficient (PD) food intake
    Hajime Tamaki
    Laboratories of Applied Biochemistry, Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara cho, Okinawa 903 0213 Japan
    Biosci Biotechnol Biochem 68:1578-80. 2004
    ..Estrogen supplementation increased bone-breaking energy (BBE), but did not increase bone mineral density (BMD), and did not decrease urinary ALP levels...
  58. ncbi Protein deficiency and muscle damage in carbon tetrachloride induced liver cirrhosis
    A Lopez-Lirola
    Departamento de Medicina Interna, Hospital Universitario, Canary Islands, Tenerife, Spain
    Food Chem Toxicol 41:1789-97. 2003
    ..Here, we analyse the effect of protein deficiency on muscle Cu, Fe, Zn, Mn and Se in carbon-tetrachloride (CCl(4)) induced liver cirrhosis...
  59. ncbi Pancreatic islet insulin secretion and metabolism in adult rats malnourished during neonatal life
    Francisco B Barbosa
    Department of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Denmark
    Br J Nutr 87:147-55. 2002
    ....
  60. ncbi Prenatal protein malnutrition induces a phase shift advance of the spontaneous locomotor rhythm and alters the rest/activity ratio in adult rats
    P Duran
    Center for Behavioral Development and Mental Retardation, M923, Boston University School of Medicine, Boston, MA 02118, USA
    Nutr Neurosci 8:167-72. 2005
    ..Alterations in entrainment to the light-dark cycle, and/or in the coupling force of the circadian oscillators are all candidate mechanisms...
  61. ncbi Long-term effect of early protein malnutrition on growth curve, hematological parameters and macrophage function of rats
    Luiz Euribel Prestes-Carneiro
    Department of Immunology, University of Oeste Paulista, Presidente Prudente, Brazil
    J Nutr Sci Vitaminol (Tokyo) 52:414-20. 2006
    ....
  62. ncbi Erythrocyte, lipid peroxidation and antioxidant enzymes in hypervitaminotic A rats and their modification by dietary protein
    P K Karar
    University Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalainagar 608 002, India
    Indian J Exp Biol 40:1250-3. 2002
    ....
  63. ncbi A tryptophan-deficient corn-based diet induces plastic responses in cerebellar cortex cells of rat offspring
    A R Del Angel-Meza
    , , Instituto Mexicano del Seguro Social, Jal, Guadalajara, Mexico
    Int J Dev Neurosci 19:447-53. 2001
    ..Consequently, several plastic and maybe compensatory events in both granule and Purkinje cells could have occurred, due to tryptophan deficiency resulting from the corn-based diet...
  64. ncbi Quantitative analysis of the neurons from the myenteric plexus in the ileum of rats submitted to severe protein deficiency
    Neide Martins Moreira
    Experimental Neurogastroenterology Laboratory, UNIPAR, Umuarama, PR, Brazil
    Arq Neuropsiquiatr 66:242-5. 2008
    ..02% more concentrated in the EG (p>0.05). NADH-diaphorase-stained neurons were 26.6% more concentrated in the EG (p<0.05), while the NADPH-diaphorase were 26.28% more concentrated in this group (p<0.05)...
  65. ncbi Influence of prenatal protein malnutrition on behavioral reactivity to stress in adult rats
    M Trzctńska
    Center for Behavioral Development and Mental Retardation Boston University School of Medicine, Boston, MA 02118, USA monikat neu edu
    Stress 3:71-83. 1999
    ..Overall these results suggest that the relationship between prenatal malnutrition and stress depends on the level of stress (acute vs. chronic), the type of behavioral measure used to assess its effects, as well as gender...
  66. ncbi The impact of maternal protein malnutrition on pre-weaning skeletal and visceral organ growth in neonatal offspring of Rattus norvegicus
    James K Fortman
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Growth Dev Aging 69:39-52. 2005
    ..The ability to protect some organs may be the result of their tighter developmental program, one that is more resistant to differences in available nutrition...
  67. ncbi The influence of folic acid, vitamins B(2) and B(6) supplementation on feed intake, body and organs weight, and liver fatty acids composition of rats subjected to 3 months moderate protein deprivation
    B Debski
    Department of Physiological Sciences, Veterinary Medicine Faculty, Warsaw Agricultural University, Warsaw, Poland
    J Vet Med A Physiol Pathol Clin Med 54:57-61. 2007
    ..It seems that enrichment of PR diet with a mixture of folic acid, vitamins B(2) and B(6) resulted in a partial reverse of growth suppression and reduction in testis size in rats...
  68. ncbi Fetal and early postnatal protein malnutrition cause long-term changes in rat liver and muscle mitochondria
    Kyong Soo Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nutr 133:3085-90. 2003
    ..Our findings indicate that poor nutrition in early life causes long-lasting changes in mitochondria that may contribute to the development of insulin resistance in later life...
  69. ncbi Spatial learning deficits induced by muscimol and CL218,872: lack of effect of prenatal malnutrition
    J Tonkiss
    Center for Behavioral Development and Mental Retardation, M923, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Nutr Neurosci 6:379-87. 2003
    ..e. those containing the alpha2, alpha3 and/or the alpha5 but not the alpha1 subunit) is modulated by BZs...
  70. ncbi Effect of protein deficiency on macroelement and trace element levels of weanling rats' small intestine and liver tissues
    D Kilicalp
    Department of Physiology, Faculty of Veterinary Medicine, University of Yuzuncu Yil, 65080 Van, Turkey
    Biol Trace Elem Res 107:255-61. 2005
    ..In the present study, the effect of protein deficiency on the small intestine and liver tissue content of macroelements and trace elements was investigated in ..
  71. ncbi Dietary protein deprivation decreases the serine phosphorylation of insulin receptor substrate-1 in rat skeletal muscle
    Y Toyoshima
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Mol Endocrinol 32:519-31. 2004
    ..using energy-restricted (pair-fed) rats and streptozotocin-induced diabetic rats suggest that dietary protein deficiency by itself alters serine phosphorylation of IRS-1, while the up-regulation of tyrosine phosphorylation ..
  72. ncbi Structure of the murine fifth complement component (C5) gene. A large, highly interrupted gene with a variant donor splice site and organizational homology with the third and fourth complement component genes
    D L Haviland
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 266:11818-25. 1991
    To understand fifth complement component (C5) gene regulation, splicing, and C5 protein deficiency at the molecular level, the organization of the murine C5 gene was determined...
  73. ncbi Comparative activity of meropenem against Pseudomonas aeruginosa strains with well-characterized resistance mechanisms
    D M Livermore
    Department of Medical Microbiology, The London Hospital Medical College, UK
    J Antimicrob Chemother 24:149-59. 1989
    ..aeruginosa strains and their enzyme-derepressed and basal mutants, indicating that the chromosomal beta-lactamase could not protect against the new carbapenem, regardless of its mode of expression...
  74. ncbi Protein/energy ratios of current diets in developed and developing countries compared with a safe protein/energy ratio: implications for recommended protein and amino acid intakes
    D Joe Millward
    Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
    Public Health Nutr 7:387-405. 2004
    ..Focusing on the diets of UK omnivores and vegetarians and on diets in India, the risk of protein deficiency is evaluated from a comparison of P/E ratios of metabolic requirements with protein-quality-adjusted P/E ..
  75. ncbi Effect of feeding protein deficient diet on phospholipid turnover and protein kinase C mediated protein phosphorylation in rat brain
    S K Bansal
    Department of Biochemistry, V P Chest Institute, University of Delhi, Delhi 110007, India
    Indian J Exp Biol 38:323-31. 2000
    ..phospholipid metabolism and in phosphorylation of endogenous substrate proteins of PKC suggest that dietary protein deficiency causes alterations in transmembrane signalling mechanism in rat brain...
  76. ncbi Increase in skeletal muscle protein content by the beta-2 selective adrenergic agonist clenbuterol exacerbates hypoalbuminemia in rats fed a low-protein diet
    A L Sawaya
    Departamento de Fisiologia, Universidade Federal de Sao Paulo, Brasil
    Braz J Med Biol Res 31:819-25. 1998
    ..3.2 mg/kg diet for 2 weeks) caused an exacerbation of the symptoms associated with protein deficiency in rats...
  77. ncbi Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP
    G Wilkening
    Kekulé Institute for Organic Chemistry and Biochemistry, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    J Biol Chem 275:35814-9. 2000
    ..The lack of ganglioside GM1 accumulation in patients suffering from either prosaposin or GM2 activator protein deficiency has led to the hypothesis that SAPs are not needed for the hydrolysis of the ganglioside GM1 in vivo...
  78. ncbi Dystrophic pathology in the intrinsic and extrinsic laryngeal muscles in the mdx mouse
    Gayle M Smythe
    School of Community Health, Charles Sturt University, PO Box 789, Albury, NSW 2640, Australia
    J Otolaryngol Head Neck Surg 38:323-36. 2009
    ..This study aimed to characterize the laryngeal muscles in the mdx mouse model of Duchenne muscular dystrophy (DMD)...
  79. ncbi Interaction of maternal protein and carbon monoxide on pup mortality in mice: implications for global infant mortality
    Jarnail Singh
    Stillman College, Tuscaloosa, Alabama 35403, USA
    Birth Defects Res B Dev Reprod Toxicol 77:216-26. 2006
    ..Unfortunately, protein deficiency in the diets of poor pregnant mothers in developing countries is widespread...
  80. ncbi Nitrogen recycling through the gut and the nitrogen economy of ruminants: an asynchronous symbiosis
    C K Reynolds
    School of Agriculture, Policy, and Development, University of Reading, Earley Gate, Reading, RG6 6AR, United Kingdom
    J Anim Sci 86:E293-305. 2008
    ..an evolutionary advantage of the ruminant in terms of absorbable protein supply during periods of dietary protein deficiency, or asynchronous carbohydrate and protein supply, but incurs a cost of greater N intakes, especially in ..
  81. ncbi Xerophthalmia secondary to alcohol-induced malnutrition
    David P Roncone
    Roholt Vision Institute, Boardman, Ohio 44512, USA
    Optometry 77:124-33. 2006
    ..The ocular manifestations of xerophthalmia include conjunctival and corneal xerosis (drying), keratomalacia (corneal necrosis/ulceration), nyctalopia (night blindness), and Bitot's spots (conjunctival lesions)...
  82. ncbi Classical infantile spinal muscular atrophy with SMN deficiency causes sensory neuronopathy
    S Rudnik-Schoneborn
    Institute for Human Genetics, University of Technology Aachen, Germany
    Neurology 60:983-7. 2003
    ..Other organ malformations or peripheral nerve involvement have been regarded as exclusion criteria for infantile SMA. Whether SMN protein deficiency can also lead to loss of sensory neurons has not been systematically addressed.
  83. ncbi Active-site-specific chaperone therapy for Fabry disease. Yin and Yang of enzyme inhibitors
    Jian Qiang Fan
    Department of Human Genetics, Mount Sinai School of Medicine, New York, NY10029, USA
    FEBS J 274:4962-71. 2007
    Protein misfolding is recognized as an important pathophysiological cause of protein deficiency in many genetic disorders. Inherited mutations can disrupt native protein folding, thereby producing proteins with misfolded conformations...
  84. ncbi [Foetal programming of nutrition-related chronic diseases]
    Helene Delisle
    Departement de Nutrition, Universite de Montreal, CP 6128 Succ Centre Ville, Montreal QC H3C 3J7, Canada
    Sante 12:56-63. 2002
    ..Dietary manipulations in animal models provide further support and mechanistic explanations, in particular protein deficiency in pregnant rats, which elevates blood pressure, impairs glucose tolerance, and increases the likelihood of ..
  85. ncbi Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle
    R D Cohn
    Department of Pediatrics, University of Essen, Germany
    J Neurol Sci 163:140-52. 1999
    ..deficiency defines a biochemical change in the composition of the plasma membrane resulting from a primary protein deficiency in the basal lamina...
  86. ncbi Molecular characterization of three new mutations causing C5 deficiency in two non-related families
    Alberto López-Lera
    Unidad de Inmunologia, Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER U 754, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain
    Mol Immunol 46:2340-7. 2009
    ..b>Protein deficiency was assessed by means of hemolytic assays, bi-dimensional double immunodiffusion, ELISA and Western blot of ..
  87. ncbi Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice
    Sabina Paglialunga
    Department of Biochemistry, McGill University, Montreal
    Am J Physiol Endocrinol Metab 294:E521-9. 2008
    ..Overall, a reduction/deficiency in ASP is associated with an antiadipogenic state and ASP may provide a target for controlling fat storage...
  88. ncbi Serum Levels of Th2-Type Immunoglobulins are Increased in Weanling Mice Subjected to Acute Wasting Protein-Energy Malnutrition
    Tirang R Neyestani
    Laboratory of Nutrition Research, National Institute of Nutrition Research and Food Technology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 3:1-6. 2004
    ..This deviation seems to be more prominent during acute protein deficiency. The increased serum levels of immunoglobulins in ZC mice were probably due to the intestinal uptake of ..
  89. ncbi Proteomic analysis of common bean seed with storage protein deficiency reveals up-regulation of sulfur-rich proteins and starch and raffinose metabolic enzymes, and down-regulation of the secretory pathway
    Frédéric Marsolais
    Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, London, ON, Canada
    J Proteomics 73:1587-600. 2010
    ..Collectively, these results have implications for the nutritional quality of common bean, and provide information on the pleiotropic phenotype associated with storage protein deficiency in a dicotyledonous seed.
  90. ncbi The effect of a low-protein diet and dietary supplementation of threonine on tyrosine and 2-(2-nitro-4-trifluoromethylbenzoyl) cyclohexane-1,3-dione-induced corneal lesions, the extent of tyrosinemia, and the activity of enzymes involved in tyrosine catab
    E A Lock
    Zeneca Central Toxicology Laboratory, Cheshire, United Kingdom
    Toxicol Appl Pharmacol 150:125-32. 1998
    ..However, our findings do illustrate that protein deficiency limits the ability of the rat to respond to a tyrosine load produced by inhibition of HPPD.
  91. pmc Haploinsufficiency for one COL3A1 allele of type III procollagen results in a phenotype similar to the vascular form of Ehlers-Danlos syndrome, Ehlers-Danlos syndrome type IV
    U Schwarze
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 69:989-1001. 2001
    ..This suggests that the major effect of many of these dominant mutations in the "minor" collagen genes may be expressed through protein deficiency rather than through incorporation of structurally altered molecules into fibrils.
  92. ncbi Enhancing essential amino acids and health benefit components in grain crops for improved nutritional values
    Ida Wenefrida
    Rice Research Station, Louisiana State University Agricultural Center, Rayne, LA 70578, USA
    Recent Pat DNA Gene Seq 3:219-25. 2009
    ..The problem is severe where rice is the major staple food. Protein deficiency involves both the quantity (amount) and quality (the content in essential amino acids) of the dietary ..
  93. ncbi Fatty acid oxidation disorders: outcome and long-term prognosis
    Bridget Wilcken
    Biochemical Genetics and Newborn Screening, The Children s Hospital at Westmead, Westmead, NSW, Australia
    J Inherit Metab Dis 33:501-6. 2010
    ..Generalised mitochondrial tri-functional protein deficiency has high early mortality rate...
  94. ncbi Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degeneratio
    Anna Richards
    Washington University School of Medicine, St Louis, Missouri, USA
    Adv Immunol 96:141-77. 2007
    ..A response to acute injury or chronic debris accumulation must be appropriately balanced. In either case, too much activation or too little regulation promotes undesirable tissue damage and human disease...
  95. ncbi Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia
    A Rotig
    INSERM U393, Département de génétique, Hopital Necker Enfants Malades, Paris, France
    Nat Genet 17:215-7. 1997
    ..Mutated frataxin triggers aconitase and mitochondrial Fe-S respiratory enzyme deficiency in FRDA, which should therefore be regarded as a mitochondrial disorder...
  96. ncbi Wistar Furth rat megakaryocytes lack dense compartments and intercellular plaques, membranous structures rich in cytoskeletal proteins
    P E Stenberg
    Department of Pathology, Oregon Health Sciences University, Portland, USA
    Cell Adhes Commun 5:397-407. 1998
    ..morphologically aberrant megakaryocytes, larger than normal mean platelet volume, and platelet alpha-granule protein deficiency. Here, ultrastructural comparisons of WF rat megakaryocytes to those of rats (Wistar) with normal platelet ..
  97. ncbi Small Cab-like proteins retard degradation of photosystem II-associated chlorophyll in Synechocystis sp. PCC 6803: kinetic analysis of pigment labeling with 15N and 13C
    Dmitrii Vavilin
    School of Life Sciences and Center for Bioenergy and Photosynthesis, Arizona State University, Tempe, AZ 85287 4501, USA
    J Biol Chem 282:37660-8. 2007
    ..Small Cab-like protein deficiency did not significantly affect photoinhibition or turnover of photosystem II-associated beta-carotene...
  98. ncbi Robust in vitro replication of Plasmodium falciparum in glycosyl-phosphatidylinositol-anchored membrane glycoprotein-deficient red blood cells
    Kovit Pattanapanyasat
    Center of Excellence for Flow Cytometry, Office for Research and Development, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 69:360-5. 2003
    ..Each PNH RBC sample was then assessed for P. falciparum infectivity across the spectrum of GPI protein deficiency. Identification methods included biotin-streptavidin for RBC populations, fluorescein isothiocyanate-labeled ..
  99. pmc Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity
    Ashley T Martino
    Department of Pediatrics, University of Florida, Gainesville, FL, USA
    PLoS ONE 4:e6376. 2009
    ..This approach has been exploited in animal models of inherited protein deficiency for systemic delivery of therapeutic proteins...
  100. ncbi Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency
    Niels Bovenschen
    Department of Plasma Proteins, Sanquin Research at CLB, Amsterdam, The Netherlands
    Blood 101:3933-9. 2003
    ..Surprisingly, plasma FVIII in MX1cre(+)LRP(flox/flox) mice increased 2-fold after RAP gene transfer. We propose that RAP-sensitive determinants other than hepatic LRP contribute to the regulation of plasma FVIII in vivo...
  101. ncbi Optico-cochleo-dentate degeneration associated with severe peripheral neuropathy and caused by peroxisomal D-bifunctional protein deficiency
    J M Schroder
    Department of Neuropathology, University Hospital, RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Acta Neuropathol 108:154-67. 2004
    ..data showed for the first time that OCDD may occur as the phenotypic expression of D-bifunctional protein deficiency, i.e., a peroxisomal disorder...

Research Grants50

  1. Model systems for hematologic disorders caused by ribosomal protein deficiency
    George Thomas; Fiscal Year: 2010
    ..Aim 3: Assess the effects of dexamethasone, lenalidomide, and leucine in an in vivo model of ribosomal protein deficiency and validate those findings in phenotyped patient samples...
  2. MODELING AND RESCUE OF DBA IN THE MOUSE
    Philip J Mason; Fiscal Year: 2010
    ..However, the relationship between ribosomal protein deficiency and defective erythropoiesis is not known...
  3. Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
    Jakub Tolar; Fiscal Year: 2013
    ..which makes RDEB an ideal model for understanding the mechanisms of cross- correction of structural protein deficiency in the extracellular matrix...
  4. Human Umami Taste: Genetics of Psychophysical Traits
    Paul A S Breslin; Fiscal Year: 2012
    ..nutritional need: access to sources of dietary protein is essential for survival and kwashiorkor (dietary protein deficiency) is one of the leading causes of death in children in developing countries...
  5. Regulation of Host Defense by IRG Proteins
    Gregory A Taylor; Fiscal Year: 2013
    ..We will determine the effect of GMS protein deficiency on regulating GKS protein levels...
  6. Type II pneumocyte engraftment of bone marrow stem cells
    Diane S Krause; Fiscal Year: 2012
    ..Further, the cells could be used vehicles for gene therapy to treat pediatric lung diseases such as surfactant protein deficiency or alpha-1 anti-trypsin deficiency.
  7. Amino Acid Regulation of the Fos/Jun Transcription Factors
    Michael S Kilberg; Fiscal Year: 2013
    ..At the level of individual tissues/cells, dietary protein deficiency is reflected as amino acid (AA) limitation and therefore, AA deprivation of cultured cells is a useful model ..
  8. Role of EHD proteins in cardiac excitability and disease
    Jerald W Curran; Fiscal Year: 2013
    ..role of these proteins in cardiac structural and electrical activity using cuttin-edge in vivo models of EHD protein deficiency. Investigations will be conducted in both healthy and failing hearts...
  9. Function of Putative Determinant in Hematopoiesis
    James J Bieker; Fiscal Year: 2013
    ..Nan mutant mouse has exposed an unexplained mechanism of gene-selective EKLF activation that leads to unique protein deficiency. The experiments of Aim 3 are designed to illuminate the molecular mechanism of the genetic distortion that ..
  10. Feeding and Pancreatic Rest in Acute Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2012
    ..However, no feeding is not an option in SAP as unopposed protein catabolism would result in lifethreatening protein deficiency within 2 weeks...
  11. Bid-mediated killing of oncogenic stem cells in chemoprevention
    Lin Zhang; Fiscal Year: 2013
    ....
  12. In-vivo miRNA Detection Using Structurally Interacting RNA (sxRNA)
    Scott A Tenenbaum; Fiscal Year: 2011
    ..sxRNA could be an RNA-based alternative to gene therapy for protein deficiency diseases, such as cystic fibrosis, or a cancer therapy...
  13. EHD proteins in cardiac membrane protein targeting and remodeling
    Peter J Mohler; Fiscal Year: 2013
    ..The goal of this proposal is to directly test the role of EHD3 and EHD3 in cardiac structural and electrical activity using innovative in vivo models of EHD protein deficiency.
  14. RENAL FUNCTION IN PROTEIN DEFICIENCY
    MANUEL MARTINEZ MALDONADO; Fiscal Year: 1990
    ..These experiments should provide important information regarding the systemic and renal hemodynamic changes associated with experimental and, possibly, human protein deficiency.
  15. TENASCIN-X AND THE EHLERS-DANLOS PHENOTYPE
    James Bristow; Fiscal Year: 2002
    ..In aim 1, TN-X mutational analysis will be performed in EDS patients with known TNX protein deficiency, in a second cohort of EDS patients in whom collagen mutations have been excluded, and a third unselected ..
  16. ANALYSIS AND MODULATION OF IMMUNITY IN GENE THERAPY
    Paula Clemens; Fiscal Year: 2003
    ..DMD provides an excellent model with which to study gene transfer treatment for an inherited protein deficiency because the mutant gene and defective protein are known, the target tissue is easily accessible and the mdx ..
  17. CELLULAR PATHOGENESIS OF PEDIATRIC LIVER DISEASE
    David Perlmutter; Fiscal Year: 2001
    ..In project 3, A. Strauss will examine the role of mitochondrial trifunctional protein deficiency in the pathogenesis of acute fatty liver of pregnancy and Reye's syndrome. In project 4, J...
  18. INTRAVITAL VIDEO-RATE CONFOCAL MICROSCOPE
    Bruce Furie; Fiscal Year: 2001
    ..of mice altered by the knockout strategy or rendered transgenic, with the net effect of creating a protein deficiency or introducing a fluorophore into a protein of interest; (3) the development of video speed confocal ..
  19. SKELETAL MUSCLE ENERGY METABOLISM IN SURGICAL PATIENTS
    Danny Jacobs; Fiscal Year: 1993
    ..Caloric or protein deficiency may result in less than optimal skeletal muscle energy metabolism thereby affecting muscle function before ..
  20. AMINO ACID REGULATION OF GENE EXPRESSION IN NEURAL CELLS
    Dorothy Gietzen; Fiscal Year: 1999
    ..pool, the development of an essential AA deficiency can occur rapidly, particularly if a mild state of protein deficiency already exists...
  21. CALCIUM AND SALT INTAKE
    MICHAEL TORDOFF; Fiscal Year: 1999
    ..e., during dietary iron or protein deficiency; reproduction; restraint; or treatment with furosemide or angiotensin-II)...
  22. Mechanism of T cell lymphoma in E protein deficiency
    Xiao Hong Sun; Fiscal Year: 2009
    ..Findings from these studies will advance our knowledge regarding the roles of E proteins in T cell development and tumor suppression, with the goal of providing the basis for effective therapies against T-ALL. ..
  23. GONADOTROPHIC HORMONES IN MALNOURISHED RATS
    DAMON HERBERT; Fiscal Year: 1980
    The proposed project will study the relationships between protein deficiency and reproduction...
  24. COMPLEMENT C5 DEFICIENCY--MOLECULAR ANALYSIS
    RICK WETSEL; Fiscal Year: 1993
    ..fragment length polymorphisms (Hind III and Pvu II) between the C5S and C5D genes correlated with the protein deficiency. The experiments outlined in this proposal will extend these preliminary findings in the mouse and will ..
  25. THE ROLE OF INSULIN IN HUMAN FETAL LUNG DEVELOPMENT
    JEANNE SNYDER; Fiscal Year: 2004
    ..is that delayed lung development in the fetus of the diabetic woman is related to surfactant-associated protein deficiency caused by high levels of insulin...
  26. CELLULAR TRANSPLANTATION IN GENETICALLY MODULATED LIVER
    Abraham Shaked; Fiscal Year: 2000
    ..The experiments will be performed in clinically-relevant models of liver-related protein deficiency, and will correlate vector expression, biological function of the transplanted cells, and alloimmune ..
  27. T LYMPHOCYTE DYSFUNCTION IN LUPUS ERYTHEMATOSUS
    Islam Khan; Fiscal Year: 2006
    ..4) To perform SLE multiplex family studies to determine (4a) The prevalence of RIbeta protein deficiency. (4a) Whether deficient PKA-I activity due to reduced/absent RIbeta protein is a heritable disorder in ..
  28. SCORE PROGRAM AT STILLMAN COLLEGE
    Jarnail Singh; Fiscal Year: 2008
    ..This, in turn, will enhance students' college experience and motivate more minority students to pursue graduate degrees in the sciences. [unreadable] [unreadable] [unreadable]..
  29. Oxidant induced gene expression in vitamin E deficient *
    Kishorchandra Gohil; Fiscal Year: 2002
    ..These molecular data may provide the basis for designing more effective protocols for dietary interventions with antioxidants that might ameliorate lung diseases induced by environmental oxidants. ..
  30. INTEGRATIVE RESPONSES TO AMINO ACID DEFICIENCY
    Dorothy Gietzen; Fiscal Year: 2004
    ..of an indispensable amino acid (IAA) deficiency can occur rapidly, particularly if a mild state of protein deficiency already exists...
  31. Role of glucocorticoids in hypoglycemia unawareness
    Lauren Jacobson; Fiscal Year: 2003
    ..abstract_text> ..
  32. ZAP70 IN T CELL DEVELOPMENT
    John Atkinson; Fiscal Year: 2002
    ..Moreover, these studies may provide additional mechanistic information for therapeutic interventions in drug design for T cell lymphomas, immunodeficiencies, autoimmune diseases, and transplantation rejection. ..
  33. Cognitive Effects of Cerebellar Lesions in Humans
    JEREMY SCHMAHMANN; Fiscal Year: 2006
    ..This study has implications for the recognition and treatment of disorders of higher order function in cerebellar patients. [unreadable] [unreadable]..
  34. CNS Counterregulatory Mechanisms
    Lauren Jacobson; Fiscal Year: 2004
    ..These studies will provide novel information on the neuropharmacology of glucose control that may reveal therapeutic strategies to prevent hypoglycemia unawareness. ..
  35. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2004
    ..We propose that these regional structural changes accompanies dilatory heart failure, and are mechanisms behind the reduction in fiber shortening and the ability of the wall to thicken during systole. ..
  36. Diet Therapy of Long-Chain Fatty Acid Oxidation Defects
    MELANIE GILLINGHAM; Fiscal Year: 2005
    ..abstract_text> ..
  37. Programming of gene expression during fetal life
    S Ozanne; Fiscal Year: 2005
    ....
  38. Brain Signaling of Essential Amino Acid Deficiency
    Dorothy Gietzen; Fiscal Year: 2006
    ..the development of an indispensable AA (IAA) deficiency can occur rapidly, particularly if a mild state of protein deficiency already exists...
  39. Translational Genetic Study of Fear and Anxiety
    ABRAHAM PALMER; Fiscal Year: 2007
    ..This training program will prepare the candidate for an academic career focused on the use of endophenotypes, animal models and bioinformatics to elucidate the genetic basis of psychiatric disease. [unreadable] [unreadable]..
  40. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
    ..abstract_text> ..
  41. Antenatal and preschool iron and zinc use and cognition
    Parul Christian; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  42. PPAR gamma Signaling and Lung Fibroblast Transdifferentiation
    Virender Rehan; Fiscal Year: 2009
    ..abstract_text> ..
  43. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2008
    ..We will test the hypothesis that minimizing the 'prestretch' tissue area can be used as an algorithm to select pacing sites which improve global and regional function in the failing heart. ..
  44. ESSENTIAL AMINO ACIDS AND SEIZURE SUSCEPTIBILITY
    Dorothy Gietzen; Fiscal Year: 2001
    ..And finally it is hoped that the seizures in a whole animal can be blocked by blocking the relevant neurotransmitter systems. ..
  45. HIGH DENSITY LIPOPROTEIN SUBSPECIES AND CORONARY DISEASE
    Bela Asztalos; Fiscal Year: 2003
    ..The investigators state that these studies should provide better understanding about the diagnosis and treatment of HDL deficiency for the prevention of CHD. ..
  46. Deciphering the Relevance and Etiology of Th2 Cytokine Skewing in WASP KO Mice
    Deanna Nguyen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  47. Attentional Dysfunction in Children with Phenylketonuria
    Georgianne Arnold; Fiscal Year: 2008
    ....
  48. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
    ....