Genomes and Genes
Summary: A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing polyuria and decreased maximal urinary concentrating ability with secondary polydipsia. (Merck Manual, 16th ed)
Publications148 found, 100 shown here
- ERK1/2 are involved in low potassium-induced apoptotic signaling downstream of ASK1-p38 MAPK pathway in cultured cerebellar granule neuronsSatoru Yamagishi
Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Brain Res 1038:223-30. 2005..These results suggest that ERK1/2 play a crucial role in LK-induced apoptosis of cultured cerebellar granule neurons and that the LK-stimulated activation of ERK1/2 is regulated by the ASK1-p38 MAPK pathway...
- Genotypic variations in photosynthetic and physiological adjustment to potassium deficiency in cotton (Gossypium hirsutum)Ning Wang
State Key Laboratory of Plant Physiology and Biochemistry, Center of Crop Chemical Control, China Agricultural University, Beijing 100193, China
J Photochem Photobiol B 110:1-8. 2012....
- Characteristics of photosynthesis and functions of the water-water cycle in rice (Oryza sativa) leaves in response to potassium deficiencyXiao Yan Weng
State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science, Zhejiang University, Hangzhou, 310058, China
Physiol Plant 131:614-21. 2007..Therefore, it is likely that a series of photoprotective mechanisms were initiated in rice plants in response to K deficiency and the water-water cycle might be critical for protecting photosynthetic apparatus under K deficiency in rice...
- Angiotensin II type 1 receptor blockade ameliorates tubulointerstitial injury induced by chronic potassium deficiencyShin Ichi Suga
Division of Nephrology, University of Washington Medical Center, Seattle, Washington, USA
Kidney Int 61:951-8. 2002..We tested the hypothesis that K+-deficiency-induced renal tubulointerstitial injury could be mediated by Ang II or a reduction in nitric oxide...
- Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiencySophia Y Breusegem
Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, USA
Am J Physiol Renal Physiol 297:F350-61. 2009....
- Partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaPi protein diffusion, clustering, and activityMakoto Inoue
Department of Medicine, University of Colorado Health Sciences Center and Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
J Biol Chem 279:49160-71. 2004In dietary potassium deficiency there is a decrease in the transport activity of the type IIa sodium/phosphate cotransporter protein (NaPi) despite an increase in its apical membrane abundance...
- Glycosphingolipids modulate renal phosphate transport in potassium deficiencyH K Zajicek
Department of Internal Medicine, The University of Texas Southwestern Medical Center and VA Medical Center, Dallas, Texas 75216, USA
Kidney Int 60:694-704. 2001..CONCLUSION: K deficiency in the rat causes inhibition of renal Na/Pi cotransport activity by post-translational mechanisms that are mediated in part through alterations in glucosylceramide content and membrane lipid dynamics...
- Regulation of phosphate transport in proximal tubulesJ Biber
Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland
Pflugers Arch 458:39-52. 2009..The regulatory mechanisms involve various signaling pathways and a number of proteins that interact with Na(+)/P(i) cotransporters...
- Chronic K depletion inhibits renal brush border membrane Na/sulfate cotransportD Markovich
Department of Physiology and Pharmacology, University of Queensland, Australia Institute of Physiology, University of Zurich, Zurich, Switzerland
Kidney Int 55:244-51. 1999....
- Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassiumS R D'Mello
Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, 75083, USA
J Neurosci Res 59:24-31. 2000..fmk, IETD.fmk, and VEID.fmk fail to affect cell death, indicating that members inhibited by these agents (such as caspases - 6 ,7, 8, 9 and 10) are also not involved in low-K+-mediated apoptosis...
- Potassium and magnesium depletions in congestive heart failure--pathophysiology, consequences and replenishmentIgor N Iezhitsa
Volgograd State Medical University, Department of Pharmacology
Clin Calcium 15:123-33. 2005..Another possibility to restore normal K and Mg status is usage of a K, Mg sparing diuretics...
- The minor regulated pathway, a rapid component of salivary secretion, may provide docking/fusion sites for granule exocytosis at the apical surface of acinar cellsAnna M Castle
Department of Cell Biology, University of Virginia Health System, School of Medicine, Charlottesville 22908 0732, USA
J Cell Sci 115:2963-73. 2002..Ensuing granule exocytosis is controlled mainly by beta-adrenergic stimulation whereas cholinergic stimulation mainly regulates the number of surface sites where release occurs...
- Evaluation of neuronal cell death by laser scanning cytometryEster Verdaguer
Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028, Barcelona, Spain
Brain Res Brain Res Protoc 9:41-8. 2002..The protocol presented here, provides a fast and sensitive assay for the analysis of neuronal viability using LSC, and can be used to study new neuroprotective drugs in neuronal cell cultures...
- Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neuronsLinda Trotter
Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
Neurosci Lett 320:29-32. 2002..These data suggest that MKK7 is responsible for activating the JNK pathway during LK-induced CGN apoptosis...
- Potassium depletion and cardiac hypertrophy: how does it work?Joseph I Shapiro
Hypertension 46:477-8. 2005
- Evidence for a modulatory effect of external potassium ions on ionic current mediated by the cardiac Na+-Ca2+ exchangerY H Zhang
Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
Cell Calcium 33:49-58. 2003..Collectively, these data suggest that external K(+) at physiologically and pathologically relevant concentrations might be able to modulate directly the activity of the cardiac Na(+)-Ca(2+) exchanger...
- L1 cell adhesion molecule is neuroprotective of alcohol induced cell deathRose Gubitosi-Klug
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106 6010, USA
Neurotoxicology 28:457-62. 2007..We conclude that ethanol interferes with processes other than L1-L1 interactions in causing cell death, and that ethanol effects would be more severe in the absence of L1...
- Effects of potassium deficiency on potassium, polyamines and amino acids in mouse tissuesA Cremades
Department of Pharmacology, Faculty of Medicine, University of Murcia, Campus de Espinardo, 30100, Murcia, Spain
Comp Biochem Physiol A Mol Integr Physiol 134:647-54. 2003..However, in the male kidney potassium deficiency was accompanied by an increase of putrescine and spermidine concentration, and a reduction of putrescine ..
- Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neuronsSteven A Smith
School of Pharmacy, The University of Queensland, St Lucia, Queensland, Australia
J Neurosci Res 77:240-9. 2004..These results clearly reinforce very specific roles for the PPAR isoforms in neurons and suggest that PPARbeta is worthy of further investigation regarding its potential role as a therapeutic target in neurodegenerative states...
- Nicotinic cholinergic stimulation promotes survival and reduces motility of cultured rat cerebellar granule cellsS Fucile
Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, P le Aldo Moro 5, I 00185 Roma, Italy
Neuroscience 127:53-61. 2004....
- Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+-deficient ratsDomenico Tricarico
Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Bari, Italy
FASEB J 18:760-1. 2004..Our data indicate that the activation of BK channel is a property of CA inhibitors that interact with the channel subunit/s and that this effect is not related to their capability to inhibit the CA enzymes...
- Potassium depletion and diastolic dysfunctionDavid B Young
Hypertension 48:201-2. 2006
- Incidence and consequences of total body potassium depletion in chronic hemodialysis patientsGeorge M Dolson
Renal Section, Department of Medicine, Veterans Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX 77030, USA
Front Biosci 8:a126-32. 2003..METHODOLOGY AND OUTCOME MEASURE: TBK by whole-body counting of 40K, dialysis potassium losses, and patient demographic characteristics were determined. Survival was evaluated retrospectively after seven years of follow-up...
- Comparison of inhibitory effects of brain-derived neurotrophic factor and insulin-like growth factor on low potassium-induced apoptosis and activation of p38 MAPK and c-Jun in cultured cerebellar granule neuronsSatoru Yamagishi
Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Brain Res Mol Brain Res 119:184-91. 2003....
- [Therapy of cardiac arrhythmias. Clinical significance of potassium- and magnesium aspartate in arrhythmias]M Manz
Klinik fur Innere Medizin, Koblenz
Fortschr Med Orig 120:11-5. 2002..Patients older than 50, and those with previous coronary heart disease and/or myocardial infarction derived particular benefit from this form of treatment...
- Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting ductPo Yin Chu
Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 285:F1179-87. 2003..This decrease in the abundance of ROMK is likely important for maintaining K+ homeostasis during K+ deficiency...
- Simulation of electrolyte nephropathy in ratsT A Gvozdenko
Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok Affiliated Department of Far Eastern Research Center, Siberian Branch of Russian Academy of Sciences
Bull Exp Biol Med 138:210-2. 2004..Morphological study confirmed the presence of interstitial and tubular disorders in rat kidneys. The model is intended for studies of the mechanisms underlying the formation, development, and correction of nephrological diseases...
- Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidneySophie de Seigneux
The Water and Salt Research Center, University of Aarhus, DK 8000 Aarhus C, Denmark
Am J Physiol Renal Physiol 293:F87-99. 2007..The increased basolateral expression of AQP2 induced by aldosterone may play a significant role in water metabolism in conditions with increased sodium reabsorption in the CCD...
- Glycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cellsM Yeste-Velasco
Unitat de Farmacologia, Facultat de Farmàcia Universitat de Barcelona, Nucli Universitari de Pedralbes, E 08028 Barcelona, Spain
Neuropharmacology 53:295-307. 2007..Therefore, there is a connection between cell cycle and GSK-3beta activation and that these, along with other mechanisms, are involved in the molecular paths leading to the apoptotic process of rat CGNs triggered by S/K withdrawal...
- Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted ratsDomenico Tricarico
Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, via Orabona no 4, 70120 Bari, Italy
Neuromuscul Disord 18:74-80. 2008..Kir6.2/SUR2A deficiency is associated with impaired muscle function in K(+)-depleted rats and in hypoPP...
- Acetazolamide prevents vacuolar myopathy in skeletal muscle of K(+) -depleted ratsD Tricarico
Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Italy
Br J Pharmacol 154:183-90. 2008..Whether these drugs prevent vacuolar myopathy, which is a pathogenic factor in hypoPP, is unknown. The effects of these drugs on the efflux of lactate from skeletal muscle were also investigated...
- Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clampC S Choi
Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California 90089-9142, USA
Am J Physiol Renal Physiol 280:F95-F102. 2001....
- Oleamide attenuates apoptotic death in cultured rat cerebellar granule neuronsJing Yu Yang
Department of Pharmacology, Shenyang Pharmaceutical University, 110016, Shenyang, PR China
Neurosci Lett 328:165-9. 2002..These data provided the first evidence of a protective effect of oleamide against apoptosis in a structurally specific manner...
- A novel N-terminal splice variant of the rat H+-K+-ATPase alpha2 subunit. Cloning, functional expression, and renal adaptive response to chronic hypokalemiaB C Kone
Department of Internal Medicine, The University of Texas Medical School, Houston, Texas 77030, USA
J Biol Chem 273:2543-52. 1998..These results demonstrate the potential for complex control of HKalpha2 gene expression by transcriptional and posttranscriptional mechanisms not recognized in other members of the Na+-K+-ATPase/H+-K+-ATPase family...
- Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cellsA Mora
, Facultad de Veterinaria, Universidad de Extremadura, Avenue Universidad s/n, , Spain
J Neurochem 78:199-206. 2001..Our results allow us to propose a new hypothesis about the action mechanism of lithium, this ion could inhibit a serine-threonine phosphatase induced by potassium deprivation...
- Renal papillary cytoplasmic granularity and potassium depletion induced by carbonic anhydrase inhibitors in ratsR A Owen
Merck Sharp and Dohme Chibret Laboratories, Department of Safety Assessment, Riom, France
Toxicol Pathol 21:449-55. 1993..Other types of diuretics that produce hypokalemia as a side effect may not deplete medullary potassium since RPCG has not been reported in humans or animals given these drugs...
- K+, Na+, Mg2+, Ca2+, and water contents in human skeletal muscle: correlations among these monovalent and divalent cations and their alterations in K+ -depleted subjectsRatree Tavichakorntrakool
Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Transl Res 150:357-66. 2007..Our study not only provided the descriptive data but also implied the balance or homeostasis of these monovalent and divalent cations in their muscle pools...
- Forelimb locomotor generators and quadrupedal locomotion in the neonatal ratB Ballion
, , , 33405 Talence Cedex, France
Eur J Neurosci 14:1727-38. 2001..In conclusion, C7-T1 spinal levels display a strong motor rhythmogenic ability; with the lumbar generators, they contribute to coordinated rhythmic activity along the entire spinal cord of a quadrupedal locomoting mammal...
- Clinical review: Thyrotoxic periodic paralysis: a diagnostic challengeAnnie W C Kung
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
J Clin Endocrinol Metab 91:2490-5. 2006..The aim of this article was to review the clinical presentation, pathogenesis, and management of thyrotoxic periodic paralysis (TPP)...
- The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidneyLiang Fang
Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Clin Invest 119:3278-89. 2009..Clathrin-dependent endocytosis plays a critical role, limiting urinary potassium loss in potassium deficiency. In renal disease, aberrant ROMK endocytosis may contribute to potassium retention and hyperkalemia...
- The importance of potassium in managing hypertensionMark C Houston
Hypertension Institute, Saint Thomas Medical Plaza, Nashville, TN 37205, USA
Curr Hypertens Rep 13:309-17. 2011..6 g per day increase in dietary potassium intake that is independent of baseline potassium deficiency. The average reduction in BP with 4.7 g (120 mmol) of dietary potassium per day is 8.0/4...
- Chronic potassium depletion induces renal injury, salt sensitivity, and hypertension in young ratsP E Ray
Center for Molecular Physiology Research, Children s Research Institute, Children s National Medical Center, Washington DC 20010, USA
Kidney Int 59:1850-8. 2001..The purpose of this study was to determine the effects of severe chronic dietary K(+) depletion on blood pressure (BP) and renal structural changes in young rats...
- The effect of salinity on photosynthetic activity in potassium-deficient barley speciesElena Degl'Innocenti
Dipartimento di Chimica e Biotecnologie Agrarie, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy
J Plant Physiol 166:1968-81. 2009The interactive effects of salinity and potassium deficiency on the growth, mineral elements and photosynthetic performance were investigated in wild (Hordeum maritimum L.) and cultivated barley (Hordeum vulgare L. var. Manel)...
- A novel potassium deficiency-induced stimulon in Anabaena torulosaAnuradha Alahari
Bhabha Atomic Research Centre, Trombay, Mumbai, India
J Biosci 29:153-61. 2004b>Potassium deficiency enhanced the synthesis of fifteen proteins in the nitrogen-fixing cyanobacterium Anabaena torulosa and of nine proteins in Escherichia coli...
- Approach to hypokalemiaSalim Lim
Department of Internal Medicine, Mobile Field Lingga Hospital, Province of Riau Archipelagos
Acta Med Indones 39:56-64. 2007Hypokalemia is frequently encountered in clinical practice. It can be due to either potassium deficiency (inadequate potassium intake or excessive potassium loss) or to net potassium shifts from the extracellular to the intracellular ..
- Hypokalemia, cardiac failure, and reporting NXY-059 safety for acute strokeVictor L Serebruany
Johns Hopkins University, Department of Neurology, Osler Medical Center, 7600 Osler Drive, Suite 307, Towson, MD 21204, USA
J Cardiovasc Pharmacol Ther 11:229-31. 2006..Importantly, potassium deficiency represents the major avoidable cause of the array of serious cardiac adverse reactions: QT-prolongation, ..
- Potassium influences on yield and quality production for maize, wheat, soybean and cottonWilliam T Pettigrew
Crop Genetics and Production Research Unit, USDA ARS, 141 Experiment Station Road, PO Box 345, Stoneville, MS 38776, USA
Physiol Plant 133:670-81. 2008..b>Potassium deficiency can lead to a reduction in both the number of leaves produced and the size of individual leaves...
- [Indications for the use of magnesium in anesthesia and intensive care]A Delhumeau
Departement d Anesthesie Reanimation, CHU, Angers
Ann Fr Anesth Reanim 14:406-16. 1995..Simultaneous administration of Mg is often required for treatment of potassium deficiency. Mg has an anti-arrhythmic effect towards digoxin-mediated dysrhythmias and torsades de pointes, and can be ..
- Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thalianaStephanie Troufflard
Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
BMC Plant Biol 10:172. 2010..Whether and how K deficient plants also alter their secondary metabolism for nutrient management and defense is not known...
- Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implicationsR C Morris
Department of Medicine, The University of California, San Francisco 94143 0126, USA
Semin Nephrol 19:487-93. 1999..subtly but chronically disorders their internal milieu, giving rise to a prolonged state of low-grade potassium deficiency and low-grade metabolic acidosis whose severity increases with age...
- [Effect of nitrogen, phosphorus and potassium deficiency on content of phenolic compounds in exudation of American ginseng]- Du Jing
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
Zhongguo Zhong Yao Za Zhi 36:326-9. 2011..In this paper we studied the root exudation of American ginseng induced by deficiency of nitrogen, phosphorus and potassium on the content of phenolic compounds...
- Mapping of QTLS for ferrous iron toxicity tolerance in rice (Oryza sativa L.)Jian Lin Wan
State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China
Yi Chuan Xue Bao 32:1156-66. 2005..2) The third QTL for LBI located at the region of RM6-RM240 on choromosome 2 was linked with the QTL for potassium uptake located at the region of RZ58-CDO686 under potassium deficiency stress.
- Plasticity of mouse renal collecting duct in response to potassium depletionLydie Cheval
Laboratoire de Physiologie et Génomique Rénales, Unité Mixte de Recherche Centre National de la Recherche Scientifique UPMC 7134, Paris, France
Physiol Genomics 19:61-73. 2004..Finally, comparison of mouse and human OMCD transcriptomes allowed us to address the question of the relevance of the mouse as a model for human physiology and pathophysiology...
- Activating transcription factor 3 up-regulated by c-Jun NH(2)-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neuronsY Mei
Department of Pharmacology, Zhongshan School of Medicine, Sun Yat Sen University, 74 Zhongshan Road II, Guangzhou 510080, China
Neuroscience 151:771-9. 2008..Taken together, our results indicate that ATF3 is a downstream target of JNK/c-Jun pathway and contributes to apoptosis induced by potassium deprivation in rat CGNs...
- A new-onset atrial fibrillation: the incidence of potassium and magnesium deficiency. The efficacy of intravenous potassium/magnesium supplementation in cardioversion to sinus rhythmJacek Cybulski
Klinika Kardiologii CMKP, Szpital Grochowski, Warszawa, Poland
Kardiol Pol 60:578-81; discussion 582. 2004
- Low levels of sodium and potassium in the water from wetlands in Minnesota that contained malformed frogs affect the rate of Xenopus developmentEric A E Garber
USDA ARS, Biosciences Research Laboratory, Fargo, North Dakota, USA
Environ Monit Assess 90:45-64. 2004....
- The regulation of renal phosphate transportJudith Blaine
Department of Medicine, University of Colorado, Denver, 80045, USA
Adv Chronic Kidney Dis 18:77-84. 2011..that affect phosphate transport include dopamine, dietary phosphate, acid-base status, lipid composition, potassium deficiency, circadian rhythm, and hypertension...
- Safety and effectiveness of a modification of diet in renal disease equation-based potassium replacement protocolScott A Chapman
Department of Pharmacy Services, North Memorial HealthCare, Robbinsdale, MN, USA
Ann Pharmacother 43:436-43. 2009....
- ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescentsD B Dunger
University of Cambridge, Department of Paediatrics, Addenbrooke s Hospital, Level 8, Box 116, Cambridge CB2 2QQ, UK
Arch Dis Child 89:188-94. 2004..There is agreement that prevention of DKA and reduction of its incidence should be a goal in managing children with diabetes...
- Macromineral disorders of the transition cowJesse P Goff
Periparturient Diseases and Immunology Unit, National Animal Disease Center, USDA Agricultural Research Service, Ames, IA 50010, USA
Vet Clin North Am Food Anim Pract 20:471-94, v. 2004..Understanding how and why these mechanisms fail may allow the practitioner to develop strategies to avoid these disorders...
- Perturbations in electrolyte levels in kenyan children with severe malaria complicated by acidosisKathryn Maitland
Centre for Geographic Medicine Research, Coast, Kenyan Medical Research Unit, Kilifi, Kenya
Clin Infect Dis 40:9-16. 2005..To date, information about the frequency of electrolyte disturbances among children with severe falciparum malaria is limited...
- Decrease in dietary K intake stimulates the generation of superoxide anions in the kidney and inhibits K secretory channels in the CCDZhi Jian Wang
Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
Am J Physiol Renal Physiol 298:F1515-22. 2010..We conclude that LK intake stimulates the generation of superoxide anion and related products and that MAPK and Src family PTK play a physiological role in inhibiting apical K channels in the principal cells in response to LK intake...
- Effects of hydration with salt repletion on renal toxicity of conventional amphotericin B empirical therapy: a prospective study in patients with hematological malignanciesCorrado Girmenia
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Via Benevento 6, 00161, Rome, Italy
Support Care Cancer 13:987-92. 2005..A protocol of hydration and electrolyte supplementation was used prospectively in patients with hematological malignancies receiving empirical AmB-d treatment to evaluate its effect on AmB-d-related renal toxicity...
- Production of 21-deoxyaldosterone by rat adrenal tissue in vitro: evidence for an alternative biosynthetic pathway of aldosteroneS Lewicka
Department of Pharmacology, University of Heidelberg, FRG
Acta Endocrinol (Copenh) 123:225-30. 1990..The results support a role for 21-deoxyaldosterone as a facultative precursor of aldosterone and indicate that the regulation of its production shows similarities to that of aldosterone...
- Transepithelial electrochemical gradients in the proximal convoluted tubule during potassium depletion in the ratD G Shirley
Division of Biomedical Sciences, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF
J Physiol 513:551-7. 1998....
- Gamble and Darrow: pathfinders in body fluid physiology and fluid therapy for children, 1914-1964M A Holliday
Department of Pediatrics, University of California San Francisco, Box 648, Inverness, CA 94937, USA
Pediatr Nephrol 15:317-24. 2000..Dan Darrow extended our understanding of how body fluids react to hyper- and hyponatremia and to potassium deficiency. He was the first to add potassium to parenteral fluid therapy...
- Potassium depletion and salt sensitivity in essential hypertensionP Coruzzi
Unità Cardiovascolare, Istituto di Semeiotica Medica Fondazione Don C Gnocchi ONLUS, University of Parma, I 43100 Parma, Italy
J Clin Endocrinol Metab 86:2857-62. 2001....
- Microglial cells protect cerebellar granule neurons from apoptosis: evidence for reciprocal signalingE Polazzi
Department of Biology, University of Bologna, Bologna, Italy
Glia 36:271-80. 2001....
- Inhibition of nuclear factor-kappaB activation induces apoptosis in cerebellar granule cellsP Piccioli
Section of Pharmacology and Neuroscience, National Institute for Cancer Research (IST, c/o Advanced Biotechnology Center (CBA, Largo Rosanna Benzi 10, 16132 Genoa, Italy
J Neurosci Res 66:1064-73. 2001..Therefore, NF-kappaB nuclear deprivation is involved in the induction of CGC apoptosis...
- [Calcium, magnesium and potassium intake in hypertension]Toshihiko Ishimitsu
Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine
Nihon Rinsho 62:65-9. 2004
- Regulation of Arabidopsis thaliana (L.) Heynh Arginine decarboxylase by potassium deficiency stressM B Watson
Botany Department, University of Georgia, Athens 30602 7271, USA
Plant Physiol 111:1077-83. 1996..ARGdc enzyme activity has been shown to be induced by many environmental factors, including potassium deficiency stress...
- [Aldosterone and magnesium]Hiroaki Matsuoka
Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine
Clin Calcium 15:187-91. 2005..Aldosterone antagonists, such as spironolactone and eplerenone, correct not only potassium deficiency but also magnesium deficiency induced by diuretics...
- Carbonic anhydrase inhibitors ameliorate the symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca2+-activated-K+ channelsDomenico Tricarico
Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, via Orabona no 4, 70126 Bari, Italy
Neuromuscul Disord 16:39-45. 2006..The activation of Ca2+-activated-K+ channel in addition to the mild diuretic effect explained the efficacy of ACTZ and DCP in K+ -deficient rats and in familial hypokalaemic-PP...
- Pleiotropic effects of potassium deficiency in a heterocystous, nitrogen-fixing cyanobacterium, Anabaena torulosaA Alahari
Cell Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
Microbiology 144:1557-63. 1998..The observed metabolic defects were reversible, and growth arrested under prolonged potassium deficiency was fully restored upon re-addition of potassium...
- Regulated expression of Arabidopsis shaker K+ channel genes involved in K+ uptake and distribution in the plantGuillaume Pilot
Biochimie et Physiologie Moleculaire des Plantes, UMR 5004, Agro M CNRS INRA UM2, 34060 Montpellier Cedex 1, France
Plant Mol Biol 51:773-87. 2003..b>Potassium deficiency, salt stress and hormonal treatments (ABA, BA, 2,4-D) were found to differentially affect channel mRNA ..
- The ameliorative effect of silicon on soybean seedlings grown in potassium-deficient mediumBao He Miao
State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing, P R China
Ann Bot 105:967-73. 2010..However, the roles played by Si in mediating deficiency in essential mineral nutrients in general and K in particular have not been investigated...
- Inhibition of Na(+),K(+)-ATPase activity in cultured rat cerebellar granule cells prevents the onset of apoptosis induced by low potassiumN K Isaev
A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
Neurosci Lett 283:41-4. 2000..Since this effect can be mimicked by a free-radical generating system, we suggest an antioxidative effect underlying ouabain-induced neuroprotection...
- Delay of natural bone loss by higher intakes of specific minerals and vitaminsA Schaafsma
Friesland Coberco Dairy Foods, Dep of Research and Development Leeuwarden, The Netherlands
Crit Rev Food Sci Nutr 41:225-49. 2001..Boron is especially effective in case of vitamin D, magnesium, and potassium deficiency. Vitamin K is essential for the activation of osteocalcin...
- [Effect of hypokalemia on glucose metabolism in primary hyperaldosteronism]Jing Zhang
Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:745-9. 2006To investigate the effect of potassium deficiency on glucose and insulin metabolism in primary hyperaldosteronism, including aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA).
- Global transcriptome profile of rice root in response to essential macronutrient deficiencyHinako Takehisa
Genome Resource Unit National Institute of Agrobiological Sciences Tsukuba, Ibaraki, Japan
Plant Signal Behav 8:e24409. 2013..deprivation, we performed microarray analysis of rice root at 6 and 24 h after nitrogen, phosphorus and potassium deficiency treatments...
- [Potassium magnesium homeostasis: physiology, pathophysiology, clinical consequences of deficiency and pharmacological correction]I N Iezhitsa
Usp Fiziol Nauk 39:23-41. 2008..K-Mg L-aspartate can be more beneficial in the treatment of several forms of primary Mg and K deficiency than K-Mg DL-aspartate and K-Mg D-aspartate...
- Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesisHenry P Parkman
Gastroenterology Section, Department of Medicine, Temple University, Philadelphia, Pennsylvania 19140, USA
Gastroenterology 141:486-98, 498.e1-7. 2011..Gastroparesis can lead to food aversion, poor oral intake, and subsequent malnutrition. We characterized dietary intake and nutritional deficiencies in patients with diabetic and idiopathic gastroparesis...
- Ammonia prevents glutamate-induced but not low K(+)-induced apoptosis in cerebellar neurons in cultureM Llansola
Laboratorio de Neurobiologia, Instituto de Investigaciones Citológicas de la FVIB, Amadeo de Saboya, 4 46010, Valencia, Spain
Neuroscience 117:899-907. 2003....
- Association of dietary sodium and potassium intakes with albuminuria in normal-weight, overweight, and obese participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) StudyKristal J Aaron
Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Clin Nutr 94:1071-8. 2011..Among obese adults, sodium intake has been associated with cardiovascular disease. Few data are available on sodium intake and albuminuria, a marker of kidney damage and risk factor for cardiovascular disease...
- Effect of magnesium depletion and potassium depletion and chlorothiazide on intracellular pH in the rat, studied by 31P NMRW R Adam
Renal Unit, Repatriation General Hospital, West Heidelberg, Victoria, Australia
Clin Exp Pharmacol Physiol 16:33-40. 1989..Both magnesium and potassium deficiency, but not chlorothiazide treatment, were associated with an extracellular alkalosis. 4...
- Gene expression analysis of rice seedling under potassium deprivation reveals major changes in metabolism and signaling componentsAlka Shankar
Department of Plant Molecular Biology, University of Delhi South Campus, Dhaula Kuan, New Delhi, India
PLoS ONE 8:e70321. 2013..b>Potassium deficiency directly affects the plant growth and hence crop yield and production...
- Protection against β adrenoceptor agonist reduction of plasma potassium in severe but not in moderate hypokalemiaCao Thach Tran
Laboratory for Molecular Cardiology 2142, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Fundam Clin Pharmacol 25:452-61. 2011..It may be advisable to avoid hypokalemia when using β adrenoceptor agonists and to maintain pK in the upper normal range if at the risk of arrhythmia...
- Cotton shoot plays a major role in mediating senescence induced by potassium deficiencyBo Li
State Key Laboratory of Plant Physiology and Biochemistry, Key Laboratory of Crop Cultivation and Farming System, Center of Crop Chemical Control, China Agricultural University, Beijing 100193, China
J Plant Physiol 169:327-35. 2012..The shoot-to-root feedback signal(s), rather than high shoot demand for K nutrition, was involved in the shoot regulation of premature senescence in cotton plants, achieved possibly by altering root K uptake...
- Potassium supplementation improves the natriuretic response to central volume expansion in primary aldosteronismPaolo Coruzzi
Dipartimento di Scienze Cliniche, Fondazione Don C Gnocchi ONLUS, University of Parma, Italy
Metabolism 52:1597-600. 2003..However, the ability of potassium deficiency to affect mineralocorticoid-induced sodium retention in aldosterone-producing adenoma (APA) subjects has ..
- Effect of plant growth on dehydration rates and microbial populations in sewage biosolidsJ R Crush
AgResearch, Ruakura Research Centre, Hamilton, New Zealand
Bioresour Technol 97:2447-52. 2006..Plant growth varied between species and potassium deficiency was found to be a limiting factor for barley...
- In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cellsE L Andrianova
Laboratory of Experimental Neurocytology, Neurology Research Center, Russian Academy of Medical Sciences, Moscow, Russia
Bull Exp Biol Med 151:30-2. 2011..Our results indicate that cyclooxygenase transformation of anandamide is followed by the loss of antitumor activity of this agent. By contrast, prostamide E2 exhibited strong neuroprotective properties...
- Transcript profile of the response of two soybean genotypes to potassium deficiencyCheng Wang
National Center for Soybean Improvement, National Key Laboratory for Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, China
PLoS ONE 7:e39856. 2012..Our results provide preliminary information on the molecular mechanism of potassium absorption and transport under low-K stress conditions in different soybean tissues...
- The role of dairy in meeting the recommendations for shortfall nutrients in the American dietTheresa A Nicklas
Department of Pediatrics, USDA ARS Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA
J Am Coll Nutr 28:73S-81S. 2009..The 2005 Dietary Guidelines Advisory Committee (DGAC) recognized calcium, potassium and magnesium, all found in high levels in dairy foods, among the shortfall nutrients in both children and adults' diets...
- Potassium deficiency results in accumulation of ultra-high molecular weight poly-beta-hydroxybutyrate in a methane-utilizing mixed cultureJ Helm
Department of Bioremediation, Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany
J Appl Microbiol 105:1054-61. 2008..To investigate the effect of various single nutrient deficiencies on poly-beta-hydroxybutyrate (PHB) biosynthesis in a methane-utilizing mixed culture (dominant species Methylocystis sp. GB 25 DSM 7674)...
- Potassium restriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidneyStephanie M Busque
Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Am J Physiol Renal Physiol 297:F440-50. 2009..Our data suggest that SNAT3 plays an important role as the glutamine uptake mechanism in ammoniagenesis under these conditions...
- Magnesium transport in the renal distal convoluted tubuleL J Dai
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Physiol Rev 81:51-84. 2001..Although it is clear that many influences affect Mg(2+) transport within the DCT, the transport processes have not been identified...
- Potassium loss with tissue potassium deficiency in rats during hypokinesiaCostas B Tsiamis
Department of Medicine, School of Medicine, Athens, Greece
Arch Med Res 39:292-8. 2008..To this end, tissue K(+) content, plasma K(+) level, and K(+) loss with and without K(+) supplements during HK were measured...
- SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neuronsK Yoshida
Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
Brain Res 873:274-82. 2000..These results suggested that SNRK may be involved in regulation of low K(+)-induced apoptosis of cultured cerebellar granule neurons...
- A paper which changed clinical practice (slowly). Jacob Holler on potassium deficiency in diabetic acidosis (1946)R B Tattersall
University of Nottingham, UK
Diabet Med 16:978-84. 1999..Also, potassium was not an electrolyte with which clinicians were familiar. Until the introduction of flame photometry in 1950, it was only measured in research studies as chemical methods took several hours to complete...
- Effect of chronic K+ deficiency on contractile properties of soleus muscle in rats: evidence of sex differencesP Piyachaturawat
Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
Clin Exp Pharmacol Physiol 26:323-9. 1999..The changes may be associated with abnormalities of muscle membrane permeability and cellular function...
- Cardiac muscle function following chronic dietary potassium depletion in the rabbitJ P Ward
Department of Medicine, United Medical School, London
Cardiovasc Res 24:647-52. 1990..The aim was to investigate a possible defect in cardiac muscle contractile performance following chronic K+ depletion...
- Regulation of ENaC TranscriptionBruce C Kone; Fiscal Year: 2013..Abnormal expression levels of this protein can result in hypertension, potassium deficiency, and edema...
- Molecular Mechanism of ROMK Channel FunctionPaul A Welling; Fiscal Year: 2013..Clathrin-dependent endocytosis plays a critical role, limiting urinary potassium loss in potassium deficiency. In renal disease, aberrant ROMK endocytosis may contribute to potassium retention and life-threatening ..
- Molecular mechanisms of ammonia metabolismI David Weiner; Fiscal Year: 2013..acid-base and potassium homeostasis in these mice under control conditions and in response to dietary potassium deficiency in order to determine Rhbg's role in the renal response to hypokalemia, and the specific contributions ..
- H/HCO3 transport in the collecting ductI David Weiner; Fiscal Year: 2013..acid-base and potassium homeostasis in these mice under control conditions and in response to dietary potassium deficiency in order to determine the specific role of Rhcg in the renal response to hypokalemia, and the specific ..
- CELL CYCLE PROTEINS IN RENAL GROWTH, INJURY, AND REPAIRPATRICIA PREISIG; Fiscal Year: 2004..Aim 4 will determine if the endothelin B receptor plays a role in chronic metabolic acidosis and chronic potassium deficiency, models of renal hypertrophy thought to be mediated by the cell cycle-independent mechanism...
- RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASESChou Long Huang; Fiscal Year: 2005..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
- Modulation of K channels in renal collecting ductWen Hui Wang; Fiscal Year: 2007....
- Iron and Vitamin E in Childhood HIV-Associated Renal DiseasePatricio Ray; Fiscal Year: 2006..The proposed studies should have a substantial impact on the goals of the National Center for Complementary and Alternative Medicine and NIH, according to the program announcement PA-02-124. [unreadable] [unreadable]..
- SELECTIVE SODIUM-SENSITIVITY IN SALT-SENSITIVE BLACKSRalph Morris; Fiscal Year: 2006..5) The acute increases in plasma Na + concentration will predict the extent of acute increases in BP, RVR and TPR. ..
- Novel Animal Model System of AIDS-Kaposi SarcomaPatricio Ray; Fiscal Year: 2005....
- Predictors of Children's Serving Sizes & Mealtime IntakeTheresa Nicklas; Fiscal Year: 2007..Understanding what influences the portion sizes of energy dense foods and FV will provide insight on intervention strategies for decreasing excessive intake of energy dense foods and increasing FV intake early in childhood. ..
- Neuroprotective properties of c-Raf inhibitorsSANTOSH D MELLO; Fiscal Year: 2008..It is our hope that GW5074 (or other c-Raf inhibitors like it) will emerge as a highly effective and versatile therapeutic agent that could proceed towards clinical trials for the treatment of neurological diseases in the near future. ..
- The CIA (Children in Action) ProgramTheresa Nicklas; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Getting a Head Start on Healthier Eating HabitsTheresa Nicklas; Fiscal Year: 2006..g., role modeling, encouragement, repeated exposure) that would be used to reinforce the impact of the FJV commercials on children's FJV preferences and consumption in an ensuing R01 grant. ..
- Food Preferences of Ethnic Minority PreschoolersTheresa Nicklas; Fiscal Year: 2003....