vitamin b 12 deficiency

Summary

Summary: A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)

Top Publications

  1. ncbi Diagnosis and treatment of vitamin B12 deficiency--an update
    Anne Mette Hvas
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
    Haematologica 91:1506-12. 2006
  2. ncbi Prevalence of cobalamin deficiency in the Framingham elderly population
    J Lindenbaum
    Department of Medicine, Columbia Presbyterian Medical Center, New York, NY 10032
    Am J Clin Nutr 60:2-11. 1994
  3. ncbi The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings
    Wolfgang Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
    Curr Drug Metab 6:47-53. 2005
  4. pmc Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo
    Qianchuan He
    Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA
    Blood 106:1447-53. 2005
  5. pmc Overview of a roundtable on NHANES monitoring of biomarkers of folate and vitamin B-12 status: measurement procedure issues
    Elizabeth A Yetley
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892 7517, USA
    Am J Clin Nutr 94:297S-302S. 2011
  6. ncbi Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians
    S Muthayya
    Division of Nutrition, Institute of Population Health and Clinical Research, St John s National Academy of Health Sciences, Bangalore, India
    Eur J Clin Nutr 60:791-801. 2006
  7. doi An update on cobalamin deficiency in adults
    N Dali-Youcef
    Service de Medecine Interne, diabète et maladies métaboliques, clinique médicale B, Hôpital Civil Hôpitaux Universitaires de Strasbourg, 1 Porte de l Hôpital, 67091 Strasbourg Cedex, France
    QJM 102:17-28. 2009
  8. pmc Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria)
    Ralph Gräsbeck
    Biochemistry Unit, Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, FI 00290 Helsinki, Finland
    Orphanet J Rare Dis 1:17. 2006
  9. pmc Effects of vitamin B12 and folate deficiency on brain development in children
    Maureen M Black
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Food Nutr Bull 29:S126-31. 2008
  10. ncbi Vitamin B12 and folate deficiency in later life
    Robert Clarke
    Clinical Trial Service Unit Division of Clinical Geratology University Department of Pharmacology, University of Oxford, Oxford, UK
    Age Ageing 33:34-41. 2004

Detail Information

Publications316 found, 100 shown here

  1. ncbi Diagnosis and treatment of vitamin B12 deficiency--an update
    Anne Mette Hvas
    Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
    Haematologica 91:1506-12. 2006
    ..Once the diagnosis of vitamin B12 deficiency has been confirmed efficient treatment can be ensured either by injections every 2-3 month or by a daily dose of 1 mg vitamin B12...
  2. ncbi Prevalence of cobalamin deficiency in the Framingham elderly population
    J Lindenbaum
    Department of Medicine, Columbia Presbyterian Medical Center, New York, NY 10032
    Am J Clin Nutr 60:2-11. 1994
    ..The prevalence of cobalamin deficiency was > or = 12% in a large sample of free-living elderly Americans. Many elderly people with "normal" serum vitamin concentrations are metabolically deficient in cobalamin or folate...
  3. ncbi The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings
    Wolfgang Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
    Curr Drug Metab 6:47-53. 2005
    ..Elevated MMA and normal holoTC in patients with renal insufficiency may not exclude vitamin B12 deficiency. HoloTC seems not to be a promising marker in predicting B12 status in renal patients...
  4. pmc Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo
    Qianchuan He
    Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA
    Blood 106:1447-53. 2005
    ..Characterization of canine AMN mutations that cause I-GS establishes the canine model as an ortholog of the human disorder well suited to studies of AMN function and coevolution with cubilin...
  5. pmc Overview of a roundtable on NHANES monitoring of biomarkers of folate and vitamin B-12 status: measurement procedure issues
    Elizabeth A Yetley
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892 7517, USA
    Am J Clin Nutr 94:297S-302S. 2011
    ..The roundtable supported the continued use of the National Institute of Standards and Technology (NIST) reference materials in NHANES biomarker analyses and the further development of additional reference materials by the NIST...
  6. ncbi Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians
    S Muthayya
    Division of Nutrition, Institute of Population Health and Clinical Research, St John s National Academy of Health Sciences, Bangalore, India
    Eur J Clin Nutr 60:791-801. 2006
    ..To assess the maternal sociodemographic, anthropometric, dietary and micronutrient status in apparently healthy pregnant women in order to determine their associations with intrauterine growth retardation (IUGR)...
  7. doi An update on cobalamin deficiency in adults
    N Dali-Youcef
    Service de Medecine Interne, diabète et maladies métaboliques, clinique médicale B, Hôpital Civil Hôpitaux Universitaires de Strasbourg, 1 Porte de l Hôpital, 67091 Strasbourg Cedex, France
    QJM 102:17-28. 2009
    ..Management of cobalamin deficiency with cobalamin injections is currently well codified, but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption...
  8. pmc Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria)
    Ralph Gräsbeck
    Biochemistry Unit, Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, FI 00290 Helsinki, Finland
    Orphanet J Rare Dis 1:17. 2006
    ..In diagnosing this disease, it is important to be aware that cobalamin deficiency affects enterocyte function; therefore, all tests suggesting general and cobalamin malabsorption should be repeated after abolishment of the deficiency...
  9. pmc Effects of vitamin B12 and folate deficiency on brain development in children
    Maureen M Black
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Food Nutr Bull 29:S126-31. 2008
    ....
  10. ncbi Vitamin B12 and folate deficiency in later life
    Robert Clarke
    Clinical Trial Service Unit Division of Clinical Geratology University Department of Pharmacology, University of Oxford, Oxford, UK
    Age Ageing 33:34-41. 2004
    ..to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom...
  11. pmc Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline
    Christine C Tangney
    Department of Clinical Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    Neurology 72:361-7. 2009
    ....
  12. doi How common is vitamin B-12 deficiency?
    Lindsay H Allen
    US Department of Agriculture, ARS Western Human Nutrition Research Center, University of California, Davis, Davis, CA 95616, USA
    Am J Clin Nutr 89:693S-6S. 2009
    ..However, intervention studies are still needed to assess efficacy and functional benefits of increasing intake of the amounts likely to be consumed in flour, including in elderly persons with varying degrees of gastric atrophy...
  13. doi Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms
    Daphna K Dror
    Department of Nutrition at the University of California Davis, Davis, California, USA
    Nutr Rev 66:250-5. 2008
    ....
  14. ncbi Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population
    Joel G Ray
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Epidemiology 18:362-6. 2007
    ..Prior studies used relatively insensitive measures of B(12), did not adjust for folate levels, and were conducted in countries without folic acid food fortification. In Canada, flour has been fortified with folic acid since mid-1997...
  15. pmc Megaloblastic anemia and other causes of macrocytosis
    Florence Aslinia
    Department of Internal Medicine, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA
    Clin Med Res 4:236-41. 2006
  16. ncbi B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans
    D Majchrzak
    Department of Nutritional Sciences, University of Vienna, Vienna, Austria
    Ann Nutr Metab 50:485-91. 2006
    ..However, a vegetarian diet may be deficient in some nutrients. Exclusion of animal products in vegetarian diets may affect the status of certain B-vitamins, and further cause the rise of plasma homocysteine concentration...
  17. ncbi Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study
    Catharina Lewerin
    Department of Medicine at the Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Am J Clin Nutr 81:1155-62. 2005
    ..Deficiencies of vitamin B-12, folic acid, and vitamin B-6-as defined by laboratory measures-occur in 10-20% of elderly subjects. The clinical significance remains unresolved...
  18. ncbi Plasma total homocysteine, folate, and vitamin B12 status in Korean adults
    Hyeon Sook Lim
    Department of Food and Nutrition, Chonnam National University, Yongbong Dong, Buk gu Gwangju, 500 757, Korea
    J Nutr Sci Vitaminol (Tokyo) 48:290-7. 2002
    ..Our results indicate that male adults may be in worse condition for cardiovascular disease (CVD) than females. And improving folate and vitamin B12 status may reduce plasma tHcy level, which may be more important in males...
  19. pmc Increased risk of cognitive impairment in patients with diabetes is associated with metformin
    Eileen M Moore
    Corresponding author Eileen M Moore
    Diabetes Care 36:2981-7. 2013
    ..To investigate the associations of metformin, serum vitamin B12, calcium supplements, and cognitive impairment in patients with diabetes...
  20. ncbi Low vitamin B-12 status and risk of cognitive decline in older adults
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:1384-91. 2007
    ..Elevated total homocysteine (tHcy) concentrations have been associated with cognitive impairment, but it is unclear whether low vitamin B-12 or folate status is responsible for cognitive decline...
  21. pmc Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicities
    Cameron M Beech
    Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Orphanet J Rare Dis 6:74. 2011
    ..We present evidence that this founder mutation causes a substantial percentage of cases among diverse ethnicities and that the mutation is as old as human civilization...
  22. doi Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect
    Seyit T Ceyhan
    Department of Obstetrics and Gynecology, Gulhane Military Medical Academy, Ankara, Turkey
    Gynecol Endocrinol 26:578-81. 2010
    ..The aim of the study is to investigate the importance of serum vitamin B12 levels in pregnant women with foetal neural tube defect (NTD)...
  23. ncbi Update on vitamin B12 deficiency
    Robert C Langan
    St Luke s Hospital, Bethlehem, PA, USA
    Am Fam Physician 83:1425-30. 2011
    ....
  24. ncbi Evaluation of macrocytosis
    Joyce Kaferle
    Department of Family Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am Fam Physician 79:203-8. 2009
    ..Of other possible etiologies, hypothyroidism, liver disease, and primary bone marrow dysplasias (including myelodysplasia and myeloproliferative disorders) are some of the more common causes...
  25. doi Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study
    Anna Vogiatzoglou
    OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Am J Clin Nutr 89:1078-87. 2009
    ..Limited information is available on the association between vitamin B-12 status and intake from different dietary sources...
  26. ncbi Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development
    Anne M Molloy
    School of Medicine, Trinity College Dublin, Ireland
    Food Nutr Bull 29:S101-11; discussion S112-5. 2008
    ..However, the implications of starting pregnancy and lactation with low vitamin B12 status have not been sufficiently researched...
  27. doi Cobalamin status in children
    Anne Lise Bjørke-Monsen
    Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
    J Inherit Metab Dis 34:111-9. 2011
    ..Cobalamin deficiency should be considered a differential diagnosis in children with subtle symptoms, and strategies to prevent cobalamin deficiency in mothers and children should be addressed...
  28. doi Vitamin B12 absorption: mammalian physiology and acquired and inherited disorders
    Renata Kozyraki
    INSERM, U968, Paris F 75012, France
    Biochimie 95:1002-7. 2013
    ..Disturbed cellular entry, transit or egress of vitamin B12 may lead to low vitamin B12 status or deficiency and eventually hematological and neurological disorders...
  29. pmc Juvenile selective vitamin B₁₂ malabsorption: 50 years after its description-10 years of genetic testing
    Ralph Gräsbeck
    Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki 00290, Finland
    Pediatr Res 70:222-8. 2011
    ..Clinical awareness must include attention to ethnicity, a sensitive topic but effective for fast diagnosis. The treatment with monthly parenteral Cbl for life offers a simple and cost-effective solution once proper diagnosis is made...
  30. ncbi Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate status
    Prachi Katre
    Kamalnayan Bajaj Diabetology Research Centre, King Edward Memorial Hospital Research Centre, Pune, India
    Asia Pac J Clin Nutr 19:335-43. 2010
    ..In vitamin B12 insufficient, folate replete pregnant women, vitamin B12 supplementation is associated with a reduction of plasma total homocysteine concentration in late pregnancy...
  31. ncbi Quantification of holo-transcobalamin, a marker of vitamin B12 deficiency
    Ebba Nexo
    Department of Clinical Biochemistry, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Chem 48:561-2. 2002
  32. ncbi B12 deficiency: a look beyond pernicious anemia
    Emmanuel Andres
    Department of Internal Medicine, Diabetes and Metabolic Diseases, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    J Fam Pract 56:537-42. 2007
  33. doi Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B₁₂ status in the elderly
    Edward Valente
    Axis Shield Diagnostics, Dundee, UK
    Clin Chem 57:856-63. 2011
    ..Vitamin B₁₂ deficiency is common among the elderly, and early detection is clinically important. However, clinical signs and symptoms have limited diagnostic accuracy and there is no accepted reference test method...
  34. doi Inborn errors of cobalamin absorption and metabolism
    David Watkins
    Department of Human Genetics, McGill University, Canada
    Am J Med Genet C Semin Med Genet 157:33-44. 2011
    ..Two other disorders, haptocorrin deficiency and transcobalamin receptor deficiency, have been described, but it is not clear that they have any consistent clinical phenotype...
  35. ncbi Low plasma vitamin B-12 in Kenyan school children is highly prevalent and improved by supplemental animal source foods
    Erin D McLean
    Department of Nutritional Biology, University of California, Davis, CA 95616, USA
    J Nutr 137:676-82. 2007
    ..001). The high prevalence of low plasma vitamin B-12 concentrations in these children is predicted by a low intake of ASF, and supplemental ASF improves vitamin B-12 status...
  36. doi Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran
    Z Abdollahi
    Family Health Department, Ministry of Health and Medical Education, Tehran University of Medical Science, Tehran, Iran
    Ann Nutr Metab 53:143-50. 2008
    ..Baseline data on folate and vitamin B(12) status are necessary before mandatory flour fortification is implemented...
  37. ncbi Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes
    S Aaron
    Neurology Unit, Department of Neurological Sciences, Christian Medical College, Vellore 632 004, Tamil Nadu, India
    Neurol India 53:55-8; discussion 59. 2005
    ..To study the clinical and laboratory features of patients admitted with vitamin B12 deficiency-related (B12def) neurological syndromes...
  38. pmc Folate and vitamin B12 status of adolescent girls in northern Nigeria
    D J VanderJagt
    Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131, USA
    J Natl Med Assoc 92:334-40. 2000
    ..We conclude that the adolescent girls we studied were at greater risk for vitamin B12 deficiency than folate deficiency. This conclusion is consistent with the fact that their diet included few foods that contained vitamin B12...
  39. ncbi Elevated serum methylmalonic acid concentrations are common among elderly Americans
    Martha Savaria Morris
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:2799-803. 2002
    ..We conclude that many elderly Americans demonstrate metabolic evidence of low B-12 status, that elevations occur frequently in the absence of traditional deficiency indicators and that levels vary with race/ethnicity and renal function...
  40. ncbi Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum
    Anne L Morkbak
    Dept of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Denmark
    Haematologica 92:1711-2. 2007
    ..The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy...
  41. ncbi Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities
    R Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, USA
    Am J Clin Nutr 70:904-10. 1999
    ..Low cobalamin concentrations and mild hyperhomocysteinemia are common in the elderly but ethnic differences have not been defined...
  42. doi Determination of serum holotranscobalamin concentrations with the AxSYM active B(12) assay: cut-off point evaluation in the clinical laboratory
    Fabrizia Bamonti
    Dipartimento Scienze Mediche, Universita degli Studi di Milano, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Fondazione IRCCS, Milan, Italy
    Clin Chem Lab Med 48:249-53. 2010
    ..A reliable early marker is required for diagnosis of cobalamin deficiency. We calculated an appropriate holotranscobalamin (HoloTC) cut-off point for identifying cobalamin deficiency using an immunoenzymatic assay...
  43. ncbi Vitamin B12 deficiency and hyperhomocysteinemia in rural and urban Indians
    C S Yajnik
    Diabetes Unit, King Edward Memorial Hospital and Research Centre, Pune, India
    J Assoc Physicians India 54:775-82. 2006
    ..Low vitamin B12 concentration in South Asian Indians is common, but the exact prevalence is not known...
  44. pmc Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies
    Ralph Green
    Department of Pathology, University of California, Davis, Sacramento, CA 95817, USA
    Am J Clin Nutr 94:666S-72S. 2011
    ..The general methods as well as their uses, indications, and limitations are presented...
  45. ncbi Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    H Refsum
    Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway
    Am J Clin Nutr 74:233-41. 2001
    ..In India, most people adhere to a vegetarian diet, which may lead to cobalamin deficiency...
  46. ncbi Total homocysteine, vitamin B(12), and total antioxidant status in vegetarians
    W Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of the Saarland, D 66421 Homburg Saar, Germany
    Clin Chem 47:1094-101. 2001
    ..We investigated vitamin B(12)-dependent metabolism and oxidative stress in groups with various or no intake of meat or animal products...
  47. ncbi Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial
    Simone J P M Eussen
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Arch Intern Med 165:1167-72. 2005
    ....
  48. doi Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin
    Rasmus Beedholm-Ebsen
    Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Blood 115:1632-9. 2010
    ..The identification of this Cbl export mechanism now allows the delineation of a coherent pathway for Cbl trafficking from food to the body cells...
  49. ncbi Neurologic complications of gastric bypass surgery for morbid obesity
    Katalin Juhasz-Pocsine
    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Neurology 68:1843-50. 2007
    ..Such procedures are not without complications, and those affecting the nervous system are often disabling and irreversible. We now describe our experience with these complications and review the pertinent literature...
  50. pmc Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial
    Jolien de Jager
    Department of Ophthalmology, Academic Medical Center, Amsterdam, Netherlands
    BMJ 340:c2181. 2010
    ....
  51. doi Vitamin B-12 and neural tube defects: the Canadian experience
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, Toronto, ON, Canada
    Am J Clin Nutr 89:697S-701S. 2009
    ..A multicenter randomized controlled trial comparing periconceptional vitamin B-12 in combination with FA against FA alone is warranted...
  52. doi The prevalence of vitamin B(12) deficiency in patients with type 2 diabetes: a cross-sectional study
    Matthew C Pflipsen
    Department of Primary Care, Raymond W Bliss Army Health Center, Ft Huachuca, AZ 85613, USA
    J Am Board Fam Med 22:528-34. 2009
    ..Metformin use and advanced age are associated with vitamin B(12) deficiency and often present in type 2 diabetic patients, yet the prevalence of vitamin B(12) deficiency in the diabetic population is unknown...
  53. ncbi Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood?
    John I Toohey
    Cytoregulation Research, Elgin, Ontario, Canada KOG 1EO
    Biofactors 26:45-57. 2006
    ..The rearranged product is readily degraded to CH3-SH, providing a mechanism for removing toxic homocysteine...
  54. doi Quantification of methylmalonic acid in human plasma with hydrophilic interaction liquid chromatography separation and mass spectrometric detection
    Hans Ake Lakso
    Department of Clinical Pharmacology, University of Umea, Umea, Sweden
    Clin Chem 54:2028-35. 2008
    ..We developed a method for quantifying MMA in plasma based on hydrophilic interaction liquid chromatography (HILIC) and single-stage negative electrospray ionization (ESI) mass spectrometry...
  55. ncbi Signs of impaired cognitive function in adolescents with marginal cobalamin status
    M W Louwman
    Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Netherlands
    Am J Clin Nutr 72:762-9. 2000
    ..38; 95% CI: -0.62, - 0.14). CONCLUSION: Our data suggest that cobalamin deficiency, in the absence of hematologic signs, may lead to impaired cognitive performance in adolescents...
  56. ncbi Genetically heterogeneous selective intestinal malabsorption of vitamin B12: founder effects, consanguinity, and high clinical awareness explain aggregations in Scandinavia and the Middle East
    Stephan M Tanner
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Hum Mutat 23:327-33. 2004
    ..We suggest that in both regions, physician awareness of this disease causes it to be more readily diagnosed than elsewhere; thus, it may well be more common worldwide than previously thought...
  57. doi Efficacy of oral cobalamin (vitamin B12) therapy
    Emmanuel Andres
    Hôpital Civil Hôpitaux Universitaires de Strasbourg, Department of Internal Medicine, Diabetes and Metabolic Diseases, clinique médicale B, 1 Porte de l Hôpital, 67091 Strasbourg Cedex, France
    Expert Opin Pharmacother 11:249-56. 2010
    ..Management of cobalamin deficiency with cobalamin injections is well codified at present, but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption...
  58. ncbi Are hematinic deficiencies the cause of anemia in chronic heart failure?
    Klaus K A Witte
    Division of Academic Cardiology, Castle Hill Hospital, Cottingham, United Kingdom
    Am Heart J 147:924-30. 2004
    ..We explored the relation between hematinic levels and hemoglobin (Hb) levels and exercise tolerance in a group of patients with CHF...
  59. ncbi Approaches to vitamin B12 deficiency. Early treatment may prevent devastating complications
    T S Dharmarajan
    Division of Geriatrics, Our Lady of Mercy Medical Center, 4141 Carpenter Ave, Bronx, NY 10466, USA
    Postgrad Med 110:99-105; quiz 106. 2001
    ..If the disorder is untreated, complications may cause significant morbidity. In this article, Drs Dharmarajan and Norkus discuss approaches to screening and diagnosis as well as the nontoxic, low-cost treatments now available...
  60. ncbi Vitamin B12: chemistry and biochemistry
    B Krautler
    Institute of Organic Chemistry, University of Innsbruck, A 6020 Innsbruck, Austria
    Biochem Soc Trans 33:806-10. 2005
    ..Microorganisms are the only natural sources of the B12-derivatives, whereas most spheres of life (except for the higher plants) depend on these cobalt corrinoids...
  61. ncbi Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet
    Katharine M Jones
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 137:1307-13. 2007
    ..Vitamin B-12 supplementation of lactating women, food fortification, and education to improve infant's vitamin B-12 status are potential interventions that can improve the vitamin B-12 status of mothers and infants in this population...
  62. ncbi Independent effect of vitamin B12 deficiency on hematological status in older Chinese vegetarian women
    T Kwok
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin
    Am J Hematol 70:186-90. 2002
    ..However, anemia associated with vitamin B(12) deficiency was seldom macrocytic. We recommend that older vegetarians should be given vitamin B(12) supplements routinely...
  63. pmc Advances in the understanding of cobalamin assimilation and metabolism
    Edward V Quadros
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Br J Haematol 148:195-204. 2010
    ....
  64. ncbi Cobalamin and folate status in infants and young children in a low-to-middle income community in India
    Sunita Taneja
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
    Am J Clin Nutr 86:1302-9. 2007
    ..Population-based data on the prevalence of cobalamin and folate deficiency in India are lacking...
  65. ncbi Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategies
    Ralph Green
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis, California, USA
    Food Nutr Bull 29:S52-63; discussion S64-6. 2008
    ..The general methods as well as their uses, indications, and limitations are presented...
  66. ncbi Holotranscobalamin in laboratory diagnosis of cobalamin deficiency compared to total cobalamin and methylmalonic acid
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1746-50. 2007
    ..Serum concentration of holoTC is a new marker in laboratory diagnosis of cobalamin deficiency. We tested the utility of holoTC in assessing vitamin B(12) status...
  67. ncbi Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered?
    G T Bondevik
    Centre for International Health, University of Bergen, Bergen, Norway
    Eur J Clin Nutr 55:856-64. 2001
    ..The aim of this study was to investigate homocysteine and methylmalonic acid levels as markers of functional cobalamin and folate status in pregnant Nepali women...
  68. doi Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy
    David S H Bell
    Southside Endocrinology and Division of Diabetes, Endocrinology, and Metabolism, University of Alabama Medical School, Birmingham, AL 35205, USA
    South Med J 103:265-7. 2010
    ..To my knowledge, this is the first report of metformin-induced vitamin B12 deficiency causing neuropathy...
  69. ncbi Review of the magnitude of folate and vitamin B12 deficiencies worldwide
    Erin McLean
    Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland
    Food Nutr Bull 29:S38-51. 2008
    ..More representative data and more consistent use of thresholds to define deficiency are needed in order to assess whether folate and vitamin B12 deficiencies are a public health problem...
  70. ncbi Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome
    H Refsum
    Department of Pharmacology, University of Bergen, Armauer Hansens Hus, 5021 Bergen, Norway
    Br J Nutr 85:S109-13. 2001
    ..This is followed by a brief discussion of some of the proposed mechanisms for their biological effects in relation to birth defects and pregnancy outcome...
  71. pmc Increases in plasma holotranscobalamin can be used to assess vitamin B-12 absorption in individuals with low plasma vitamin B-12
    Dattatray S Bhat
    Kamalnayan Bajaj Diabetology Research Centre, King Edward Memorial Hospital Research Centre, Pune, India
    J Nutr 139:2119-23. 2009
    ..Because malabsorption is unlikely to be a major reason for the low plasma vitamin B-12 concentrations in this population, increasing dietary vitamin B-12 should improve their status...
  72. ncbi Vitamin B12 deficiency - why refugee patients are at high risk
    Jill Benson
    Health in Human Diversity Unit, Discipline of General Practice, University of Adelaide, and Migrant Health Service, Tullawon Health Service Yalata Community, South Australia, Australia
    Aust Fam Physician 39:215-7. 2010
    ..Vitamin B12 is one of the most complex vitamins. The measurement of serum levels and the significance of the results are much debated in the literature...
  73. ncbi Prevalence of low serum folate and vitamin B12 in an older Australian population
    Victoria M Flood
    Department of Public Health, Centre for Vision Research, Westmead Millennium Institute, University of Sydney, New South Wales
    Aust N Z J Public Health 30:38-41. 2006
    ..To examine the prevalence of low serum folate and vitamin B12, in association with elevated serum homocysteine, in a representative sample of older Australians...
  74. ncbi Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
    J Nutr 134:750-5. 2004
    ..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis...
  75. pmc Association between vitamin B12-containing supplement consumption and prevalence of biochemically defined B12 deficiency in adults in NHANES III (third national health and nutrition examination survey)
    Marian L Evatt
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30329, USA
    Public Health Nutr 13:25-31. 2010
    ..To explore the association between vitamin B(12) (B(12))-containing supplement use, low B(12) concentrations and biochemically defined B(12) deficiency in US adults...
  76. ncbi Cobalamin deficiency due to non-immune atrophic gastritis in elderly patients. A report of 25 cases
    N Henoun Loukili
    Department of Internal Medicine, Diabetes and Metabolic Disorders, Hopitaux Universitaires de Strasbourg, France
    J Nutr Health Aging 9:462. 2005
  77. doi Nutritional anemias and the elderly
    Ralph Carmel
    Departments of Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USA
    Semin Hematol 45:225-34. 2008
    ..Nutritional anemias usually feature abnormal MCV, whereas the predominant anemias in the aged, especially the anemias of chronic disease/chronic inflammation (ACD/ACI), of renal failure, and of unknown causes, are typically normocytic...
  78. pmc Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns
    Stephan M Tanner
    Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Orphanet J Rare Dis 7:56. 2012
    ..IGS and IFD differ in that IGS usually presents with proteinuria, which is not observed in IFD. The genetic heterogeneity and numerous differential diagnoses make clinical assessment difficult...
  79. doi Vitamin B12-responsive severe leukoencephalopathy and autonomic dysfunction in a patient with "normal" serum B12 levels
    J J Graber
    Department of Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Neurol Neurosurg Psychiatry 81:1369-71. 2010
    ....
  80. doi Partial characterization of cobalamin deficiency in Chinese Shar Peis
    Micah A Bishop
    Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4474, USA
    Vet J 191:41-5. 2012
    ..In conclusion, Shar Peis have a high prevalence of cobalamin deficiency compared to other breeds and healthy Shar Peis may have subclinical cobalamin deficiency...
  81. ncbi Hyperammonaemic encephalopathy secondary to selective cobalamin deficiency in a juvenile Border collie
    I A Battersby
    Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU
    J Small Anim Pract 46:339-44. 2005
    ....
  82. ncbi [B12 vitamin deficiency and oral treatment. An option as efficient as (still) infrequently used]
    J E Mariño Suárez
    Medico de Familia, Centro de Salud El Greco, Getafe, Madrid, Espana
    Aten Primaria 32:382-7. 2003
  83. pmc Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility
    Ebba Nexo
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Am J Clin Nutr 94:359S-365S. 2011
    ..To date, holoTC has not been used for population-based assessments of vitamin B-12 status, but we suggest that holoTC is a better marker than total vitamin B-12 for such studies...
  84. ncbi Prevalence of folate and vitamin B12 deficiency in Mexican children aged 1 to 6 years in a population-based survey
    Lucia Cuevas-Nasu
    Instituto Nacional de Salud Publica, Morelos, Mexico
    Salud Publica Mex 54:116-24. 2012
    ..To describe the magnitude and distribution of folate and vitamin B12 deficiency in Mexican children...
  85. ncbi Vitamin B-12 metabolism in HIV-infected patients in the age of highly active antiretroviral therapy: role of homocysteine in assessing vitamin B-12 status
    Angel F Remacha
    Department of Hematology, Hospital de Sant Pau, Barcelona, Spain
    Am J Clin Nutr 77:420-4. 2003
    ..However, few patients had real vitamin B-12 deficiency...
  86. ncbi [Homozygous mutation in the intrinsic factor gene in a child with severe vitamin B12 deficiency]
    Tina Lund Leunbach
    Børneafdelingen, Aarhus Universitetshospital, Aalborg Sygehus, 9000 Aalborg, Denmark
    Ugeskr Laeger 173:2047-8. 2011
    ..Gastroscopy with biopsies showed no pathology. All were given monthly cyanocobalamin injections which, however, caused leg cramps. Replacement with monthly hydroxocobalamin was successful...
  87. ncbi Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study
    Katherine L Tucker
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Bone Miner Res 20:152-8. 2005
    ..Men with plasma B12 < 148 pM had significantly lower BMD at the hip, and women at the spine, relative to those with higher B12, and trends were similar for both at all sites. Low vitamin B12 may be a risk factor for low BMD...
  88. doi LMBRD1: the gene for the cblF defect of vitamin B₁₂ metabolism
    Frank Rutsch
    Department of General Pediatrics, Münster University Children s Hospital, Munster, Germany
    J Inherit Metab Dis 34:121-6. 2011
    ..These studies give further insight into the intracellular transport of vitamins, challenge the views on lipocalin receptors, and add to our understanding of lysosomal diseases...
  89. ncbi Proteinuria in cubilin-deficient patients with selective vitamin B12 malabsorption
    Virve Wahlstedt-Fröberg
    The Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
    Pediatr Nephrol 18:417-21. 2003
    ..The proteinuria was not of the classical glomerular or tubular type, but apparently due to the lack of cubilin function needed for tubular reabsorption of some, but not all, proteins of the primary urine...
  90. pmc Diagnosing vitamin B-12 deficiency on the basis of serum B-12 assay
    Vinod Devalia
    Princess of Wales Hospital, Bridgend CF31 1RQ
    BMJ 333:385-6. 2006
  91. ncbi Vitamin B-12 treatment has limited effect on health-related quality of life among individuals with elevated plasma methylmalonic acid: a randomized placebo-controlled study
    A M Hvas
    Department of Haematology, Aas, Aarhus University Hospital, Aarhus Kommunehospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
    J Intern Med 253:146-52. 2003
    ..To examine the hypothesis that treatment with vitamin B-12 improves health-related quality of life (HRQOL) in individuals with biochemical signs of vitamin B-12 deficiency...
  92. doi Periventricular white matter lucencies relate to low vitamin B12 levels in patients with small vessel stroke
    Barbe Pieters
    Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands
    Stroke 40:1623-6. 2009
    ..Because vitamin B12 plays a role in maintaining the integrity of the blood-brain barrier, we studied serum vitamin B12 level in relation to such lesions...
  93. ncbi Metformin-associated vitamin B12 deficiency
    Emmanuel Andres
    Arch Intern Med 162:2251-2. 2002
  94. ncbi [Combined sclerosis of the spinal cord revealing vitamin B 12 deficiency: geriatric characteristics apropos of a case evaluated by MRI]
    O Beauchet
    Service de Gerontologie Clinique, Hôpital de la Charité, CHU, 42055 Saint Etienne, France
    Rev Med Interne 23:322-7. 2002
    ..A subacute combined degeneration of the spinal cord accounts for only 10% of the neurological complications. Revealing forms of this myelopathy are exceptional, and were rarely documented by magnetic resonance imaging (MRI) study...
  95. ncbi Homozygous AMN mutation in hereditary selective intestinal malabsorption of vitamin B12 in Jordan
    Jamil R Al-Alami
    Department of Biochemistry and Medical Laboratory Science, Jordan University of Science and Technology, Irbid, Jordan
    Saudi Med J 26:1061-4. 2005
    ..Several syndromes present with megaloblastic anemia such as congenital megaloblastic anemia due to intrinsic factor defect and juvenile megaloblastic anemia with proteinuria due to defects in the cubilin or the amnionless protein...
  96. pmc Mandatory fortification of the food supply with cobalamin: an idea whose time has not yet come
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY, 11215, USA
    J Inherit Metab Dis 34:67-73. 2011
    ..Extensive work, especially randomized clinical trials, must be done before mandatory dietary intervention on a national scale can be justified...
  97. ncbi Comparing costs of intramuscular and oral vitamin B12 administration in primary care: a cost-minimization analysis
    Josep Vidal-Alaball
    National Public Health Service for Wales, Swansea, Wales, UK
    Eur J Gen Pract 12:169-73. 2006
    ..To establish whether savings could be made by changing patients from intramuscular to high doses of oral vitamin B12 in primary care without compromising their wellbeing...
  98. doi Vitamin B12 deficiency in a 9-month-old boy
    Christine Quentin
    Department of Hematology and Oncology, Universite Libre de Bruxelles, Queen Fabiola Children s Hospital, Brussels, Belgium
    Eur J Pediatr 171:193-5. 2012
    ..Therefore, evaluation of vitamin B12 status during pregnancy and lactation is necessary in order to prevent B12 deficiency and its possible long-term effects in infants...
  99. pmc Juvenile cobalamin deficiency in a 17-year-old child with autonomic dysfunction and skin changes
    Abdul Hafeez Siddiqui
    Department of Pediatrics, University of South Alabama College of Medicine, Mobile, AL, USA
    J Pediatr Hematol Oncol 34:140-2. 2012
    ..The expected macrocytosis was masked by an underlying alpha-thalassemia trait. The patient had an excellent response to parenteral cobalamin treatment...
  100. ncbi [Hereditary juvenile cobalamin deficiency due to mutations in GIF gene]
    M C Garcia Jimenez
    Unidad de Metabolismo, Hospital Universitario Infantil Miguel Servet, Saragossa, Spain
    An Pediatr (Barc) 69:56-8. 2008
    ..The identification of disease-causing mutations in specific genes has improved our ability to diagnose many of these conditions...
  101. doi Oral cobalamin (vitamin B(12)) treatment. An update
    E Andres
    Department of Internal Medicine, Diabetes and Metabolic Diseases, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    Int J Lab Hematol 31:1-8. 2009
    ..This present review confirms the previously reported efficacy of oral cobalamin treatment in adult and elderly patients...

Research Grants74

  1. A finger-prick medical diagnostic for vitamin B12 malabsorption: An early interv
    STEPHEN DUEKER; Fiscal Year: 2006
    ..The work is significant as it would lead to a needed convenient diagnostic test for the clinical B12 malabsorption that can be employed in the clinic or in research settings. [unreadable] [unreadable] [unreadable]..
  2. A Novel Diagnostic Test To Detect Vitamin B12 Deficiency
    David Wagner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and Bone
    Yu Xiao Yang; Fiscal Year: 2013
    ....
  4. B12 Absorption, Kinetics and Transcobalamin Genotype
    Joshua Miller; Fiscal Year: 2004
    ..This novel method would ultimately replace the Schilling test, the current gold standard, but flawed and cumbersome method for clinical assessment of B 12 absorptive capacity. ..
  5. Rapid, Inexpensive Microchip Assay for Homocysteine
    Dale Willard; Fiscal Year: 2009
    ..This is because devices like ours offer cheaper testing, closer to the patient, reduction in healthcare costs, and enhancements the physician-patient dialog and thus improving care. ..
  6. TREATMENT OF AIDS VACUOLAR MYELOPATHY WITH METHIONINE
    Alessandro DiRocco; Fiscal Year: 2002
    ..We request to complete the clinical trial and the metabolic observations of the study. ..
  7. EARLY URINE B12 DEFICIENCY DETECTION IN ELDERLY
    ERIC NORMAN; Fiscal Year: 1990
    ....
  8. FOLIC ACID REQUIREMENTS AND ONE CARBON METABOLISM
    Barry Shane; Fiscal Year: 2004
    ....
  9. METABOLIC STUDIES IN DEMENTIA, AGING AND DEMYELINATION
    STUART SCHNECK; Fiscal Year: 1993
    ..Core A provides clinical, neuropathological and statistical support while Core B provides administrative assistance...
  10. LIPOTROPE MEDIATED PROGRAMMED CELL DEATH IN MCF7 CELLS
    Chung Park; Fiscal Year: 1999
    ....
  11. A Novel Diagnostic Test To Detect Vitamin B12 Deficiency
    David Wagner; Fiscal Year: 2003
    b>Vitamin B 12 deficiency is a common, but under diagnosed condition found primarily in the elderly. This deficiency mainly results from changes in the gastrointestinal tract that take place during aging and from certain medications...
  12. VITAMIN B12 DEFICIENCY IN RHESUS MONKEYS
    DIMITRIS AGAMANOLIS; Fiscal Year: 1980
    ....
  13. SUBTLE DISTURBANCES OF COBALAMIN STATUS
    Ralph Carmel; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. FOLATE DEFICIENCY DURING CANCER CHEMOTHERAPY
    Mark Koury; Fiscal Year: 2000
    ..abstract_text> ..
  15. Measurement of folate in fortified cereal grain products
    Jacob Selhub; Fiscal Year: 2003
    ..In order to assess the impact of folic acid fortification, it is necessary to have valid data on the actual synthetic folic acid content of fortified foods. ..
  16. Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring Study
    Jacob Selhub; Fiscal Year: 2010
    ..5 About 3-5 percent of seniors have low circulating vitamin B12 levels;6 however, about 20 percent of seniors are found to be deficient when those with elevated methylmalonic acid levels are included. ..
  17. FOOD FOLATE FORTIFICATION EFFECT ON FOLATE STATUS
    Jacob Selhub; Fiscal Year: 2001
    ..abstract_text> ..
  18. Vitamin B6, Vascular Dysfunction and Adhesion Molecules in Sickle Cell Disease
    Ralph Green; Fiscal Year: 2010
    ..The positive health impact of vitamin supplementation that could ameliorate the high morbidity and mortality associated with this disorder has the potential for high benefit with minimal cost and risk. ..
  19. Vitamin B12 Status of Elderly Americans
    MARTHA MORRIS; Fiscal Year: 2003
    ..The third aim is to evaluate the usefulness of a serum vitamin B12 cut-off point of 258 pmol/L, either as the sole indicator of vitamin B12 deficiency in the elderly, or in conjunction with anemia or an elevated metabolite level. ..
  20. B12 Nutrition in the Aged
    Sally Stabler; Fiscal Year: 2007
    ..This paradox is explained because many seniors continue to have undiagnosed and untreated vitamin B 12 deficiency as shown by elevated serum methylmalonic acid concentrations...
  21. Folate, DNA Methylation and Breast Tumorigenesis
    Joshua Miller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. VASCULAR EFFECTS OF HOMOCYSTEINE IN HUMANS
    WILLIAM HAYNES; Fiscal Year: 2005
    ..The results may also suggest novel potential therapeutic approaches to be tested in future outcome trials. ..
  23. Helicobacter pylori: Pathogenesis and Virulence
    Kenneth Simpson; Fiscal Year: 2005
    ....
  24. Center for Research/Nutrition & Health among the Elderly
    Katherine Tucker; Fiscal Year: 2007
    ..Three cores will work with all projects, including administrative, statistical and laboratory cores. A pilot grants program during years 2-4 will encourage additional investigations relevant to the Center theme. ..
  25. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2010
    ..abstract_text> ..
  26. ZINC AND IRON SUPPLEMENTATION: IMPACT ON DEVELOPMENT
    Maureen Black; Fiscal Year: 2002
    ..The results have important public health implications regarding the timing of micronutrient supplementation and the relationship between micronutrient deficiency and children's behavior and development. ..
  27. Homeostatic Regulation of Folate Metabolism
    Patrick J Stover; Fiscal Year: 2010
    ..5. regulation of cSHMT by folate/choline preserves dTMP pools at the expense of AdoMet synthesis. The long-term goals of this project are: 1. to define homeostatic mechanisms used bv cells to regulate folate metabolism. ..
  28. Epigenetic effects of chronic alcohol consumption on colonic mucosa
    SANG WOON CHOI; Fiscal Year: 2007
    ..If those studies can precisely define the epigenetic mechanism for alcohol-associated carcinogenesis, we can develop a new chemopreventive strategy for those cancers. [unreadable] [unreadable] [unreadable]..
  29. SELF-CARE IN SYMPTOM MANAGEMENT AT THE END OF LIFE
    Karolynn Siegel; Fiscal Year: 2002
    ..Specifically we will investigate: 1) the symptom appraisal process; 2) coping responses to common symptoms: 3) the kinds of self-care activities employed; 4) emotional responses to common symptoms. ..
  30. EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
    Charles Halsted; Fiscal Year: 2007
    ..By confirming the relationship of abnormal methionine metabolism to clinical, biochemical, and pathologic disease severity, the study will establish a metabolic basis for determining the efficacy of SAM intervention in ALD. ..
  31. MSMW: Pathways, Motives and Behaviors
    Karolynn Siegel; Fiscal Year: 2009
    ..The study's finding will offer novel and important information about a high risk subpopulation of MSMW, and will yield important information that can guide the development of preventive interventions. ..
  32. Epidemiology of Recurrent Aphthous Stomatitis
    Lorena Baccaglini; Fiscal Year: 2007
    ..Understanding the cause of canker sores can lead to better treatments for patients affected by this condition. [unreadable] [unreadable] [unreadable]..
  33. DBS Effects on Mood and Cognition in Parkinsons Disease
    Michael Okun; Fiscal Year: 2007
    ..This proposal includes active and experienced mentoring, access to diverse resources, and a scientific environment suited specifically for the development of the PI as an independent physician scientist. ..
  34. Prenatal Drug Exposure: Effects on Adolescent Brain and Behavioral Development
    Maureen Black; Fiscal Year: 2009
    ..This application examines adacemic performance, socio-emotional functioning, and drug use among adolescents exposed to cocaine and/or heroin prenatally ..
  35. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
  36. 2007 International Peripheral Nerve Society Meeting at Snowbird, Utah
    A Smith; Fiscal Year: 2007
    ..The meeting directly impacts public health and patient care by disseminating important new ideas (both research and therapeutic) and by developing consensus guidelines. [unreadable] [unreadable] [unreadable]..
  37. Toddler Feeding Styles
    Maureen M Black; Fiscal Year: 2010
    ..abstract_text> ..
  38. The CASCADE Study: End-of-Life in Advanced Dementia
    Susan Mitchell; Fiscal Year: 2008
    ..abstract_text> ..
  39. The ADEPT Study: Estimating Prognosis in Advanced Dementia
    Susan Mitchell; Fiscal Year: 2009
    ..Thus, the information derived from this study has the potential to make important clinical, research and policy-relevant contributions to the care of older persons with dementia at the end-of-life. ..
  40. NUTRITIONAL BIOCHEMISTRY AND EPIDEMIOLOGY OF CANCER
    Steven Zeisel; Fiscal Year: 2006
    ..We are requesting two postdoctoral and six predoctoral trainee positions each year for this purpose. ..
  41. Studies of Human Folate Hydrolase
    Charles Halsted; Fiscal Year: 2005
    ..abstract_text> ..
  42. Oleic Acid Effects on Transit and Absorption in SBS
    Charlene Compher; Fiscal Year: 2004
    ....
  43. HIV-Infected IDU Living with HCV Coinfection
    Karolynn Siegel; Fiscal Year: 2005
    ..abstract_text> ..
  44. Mood Disorders & Diabetes: Common Disease Mechanisms
    WILLIAM REGENOLD; Fiscal Year: 2005
    ..S. Such treatments could have the potential not only to provide symptom relief but also to repair and prevent the brain disease contributing to treatment resistance. ..
  45. Effect of hormonal contraception on bone mineral density
    Abbey Berenson; Fiscal Year: 2005
    ..Ultimately, this study will determine which women, if any, are placed at increased risk of osteopenia or osteoporosis as a result of using these hormonal contraceptives during their reproductive years. ..
  46. Postoperative dietary counseling after bariatric surgery
    DAVID SARWER; Fiscal Year: 2005
    ..Results of this study could have a significant impact on the postoperative care of these individuals. ..
  47. Tube-feeding in Elderly: Decision-making and Outcomes
    Susan Mitchell; Fiscal Year: 2003
    ..By the end of the award period the applicant will have the skills, experience and research track record necessary to become an independent investigator and leader in academic geriatrics. ..
  48. Symptom Interpretation & Oral Health among Harlem Adults
    Karolynn Siegel; Fiscal Year: 2005
    ..In depth face-to-face, focused interviews will be conducted with 120 adults. As in several of the principal Investigator's previous federally funded investigations, qualitative research methods will be employed. ..
  49. Omega-3 Fatty Acids in the Treatment of Depression
    David Mischoulon; Fiscal Year: 2005
    ..It is hoped that this project will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator. ..
  50. A Novel Approach to Carbon-13 Breath Tests
    David Wagner; Fiscal Year: 2002
    ..Our long-term objective is to use RID technology to develop a family of gastrointestinal stable isotope breath tests that are clinically useful and low cost. ..
  51. A NOVEL METHOD TO DETECT HELICOBACTER PYLORI IN CHILDREN
    David Wagner; Fiscal Year: 2004
    ..The simplicity of the Ez-HBT(TM) including no test meal, a tablet that can be dissolved in a glass of water and a single traditional venipuncture makes it an ideal and cost effective tool for identifying H. pylori infection in children. ..
  52. A Novel Diagnostic Test for Irritable Bowel Syndrome
    David Wagner; Fiscal Year: 2002
    ..abstract_text> ..
  53. Omega-3 Fatty Acids for Treatment of Major Depression
    David Mischoulon; Fiscal Year: 2010
    ..e. integrates biological findings with treatment in order to have a direct impact on the clinical practice of psychiatry. ..
  54. Implementation of Asthma Guidelines in Primary Care; Comparison of 4 approaches
    James W Mold; Fiscal Year: 2010
    ..If effective, the same strategies could be used to facilitate implementation of other chronic disease guidelines. ..
  55. A Breath Test to Detect Bacterial Overgrowth in Elderly
    David Wagner; Fiscal Year: 2003
    ..abstract_text> ..
  56. New DHFR Deletion Polymorphism - A Risk Factor for SB?
    William Johnson; Fiscal Year: 2003
    ..Forms of foliate that are already reduced could be preferable as foliate supplements during pregnancy for prevention of SB. ..
  57. Gordon Research Sponsored Conference on Cobalamins
    Ruma Banerjee; Fiscal Year: 2003
    ....
  58. Effect of aging on folate metabolism in the colon
    SANG WOON CHOI; Fiscal Year: 2003
    ....
  59. Nutritional Influences on Aresenic Toxicity
    Mary Gamble; Fiscal Year: 2006
    ..abstract_text> ..
  60. REGULATION OF FOLATE CATABOLISM
    PATRICK STOVER; Fiscal Year: 2007
    ..2). to determine the risk that folate catabolism contributes to folate-associated pathologies. (3). to establish relationships between catecholamines and folate metabolism. ..
  61. Diethanolamine, brain development and adult memory
    Steven Zeisel; Fiscal Year: 2006
    ..abstract_text> ..
  62. SAMe and Folate Deficiency in Alcoholic Mircropigs
    Charles Halsted; Fiscal Year: 2006
    ..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. [unreadable] [unreadable] [unreadable]..
  63. Renal Transplantation, Homocysteine Lowering & Cognition
    Irwin Rosenberg; Fiscal Year: 2007
    ..Demonstrating the cognitive benefits of lowering homocysteine may pave the way to nutritional modification of cognitive decline in RTRs and other high-risk groups and even in the general population. ..
  64. Obesity, Body Image and Weight Maintenance
    DAVID SARWER; Fiscal Year: 2005
    ..These studies have been selected to further develop my knowledge of the treatment of obesity, and the training program has been designed to facilitate my development as an independent investigator in the field of obesity. ..
  65. Plasma Markers of Dietry Intervention to Delay Cognitiv*
    JAE KANG; Fiscal Year: 2005
    ..Importantly, results from the proposed grant will lay the groundwork for a future, large-scale comprehensive study to examine dietary interventions to delay cognitive function. ..
  66. Antenatal and preschool iron and zinc use and cognition
    Parul Christian; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  67. CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIA
    Chaim Hershko; Fiscal Year: 2001
    ..abstract_text> ..
  68. Micronutrients, stroke and cognition in aging
    Irwin Rosenberg; Fiscal Year: 2006
    ..abstract_text> ..
  69. Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
    Christopher H van Dyck; Fiscal Year: 2010
    ..This Pilot Clinical Trial will provide essential preliminary data for a subsequent full-scale trial of guanfacine for prefrontally-mediated cognitive dysfunction in elderly subjects. ..
  70. FASEB Summer Conference: Folate, B12 and 1C Metabolism
    PATRICK STOVER; Fiscal Year: 2004
    ..Similarly, the poster sessions also highlight the activities and needs of the younger participants. ..
  71. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    ..unreadable] [unreadable]..