Genomes and Genes
vitamin b 12 deficiency
Summary: A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)
Publications316 found, 100 shown here
- Diagnosis and treatment of vitamin B12 deficiency--an updateAnne Mette Hvas
Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Denmark
Haematologica 91:1506-12. 2006..Once the diagnosis of vitamin B12 deficiency has been confirmed efficient treatment can be ensured either by injections every 2-3 month or by a daily dose of 1 mg vitamin B12...
- Prevalence of cobalamin deficiency in the Framingham elderly populationJ Lindenbaum
Department of Medicine, Columbia Presbyterian Medical Center, New York, NY 10032
Am J Clin Nutr 60:2-11. 1994..The prevalence of cobalamin deficiency was > or = 12% in a large sample of free-living elderly Americans. Many elderly people with "normal" serum vitamin concentrations are metabolically deficient in cobalamin or folate...
- The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settingsWolfgang Herrmann
Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
Curr Drug Metab 6:47-53. 2005..Elevated MMA and normal holoTC in patients with renal insufficiency may not exclude vitamin B12 deficiency. HoloTC seems not to be a promising marker in predicting B12 status in renal patients...
- Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivoQianchuan He
Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA
Blood 106:1447-53. 2005..Characterization of canine AMN mutations that cause I-GS establishes the canine model as an ortholog of the human disorder well suited to studies of AMN function and coevolution with cubilin...
- Overview of a roundtable on NHANES monitoring of biomarkers of folate and vitamin B-12 status: measurement procedure issuesElizabeth A Yetley
Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892 7517, USA
Am J Clin Nutr 94:297S-302S. 2011..The roundtable supported the continued use of the National Institute of Standards and Technology (NIST) reference materials in NHANES biomarker analyses and the further development of additional reference materials by the NIST...
- Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South IndiansS Muthayya
Division of Nutrition, Institute of Population Health and Clinical Research, St John s National Academy of Health Sciences, Bangalore, India
Eur J Clin Nutr 60:791-801. 2006..To assess the maternal sociodemographic, anthropometric, dietary and micronutrient status in apparently healthy pregnant women in order to determine their associations with intrauterine growth retardation (IUGR)...
- An update on cobalamin deficiency in adultsN Dali-Youcef
Service de Medecine Interne, diabète et maladies métaboliques, clinique médicale B, Hôpital Civil Hôpitaux Universitaires de Strasbourg, 1 Porte de l Hôpital, 67091 Strasbourg Cedex, France
QJM 102:17-28. 2009..Management of cobalamin deficiency with cobalamin injections is currently well codified, but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption...
- Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria)Ralph Gräsbeck
Biochemistry Unit, Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, FI 00290 Helsinki, Finland
Orphanet J Rare Dis 1:17. 2006..In diagnosing this disease, it is important to be aware that cobalamin deficiency affects enterocyte function; therefore, all tests suggesting general and cobalamin malabsorption should be repeated after abolishment of the deficiency...
- Effects of vitamin B12 and folate deficiency on brain development in childrenMaureen M Black
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Food Nutr Bull 29:S126-31. 2008....
- Vitamin B12 and folate deficiency in later lifeRobert Clarke
Clinical Trial Service Unit Division of Clinical Geratology University Department of Pharmacology, University of Oxford, Oxford, UK
Age Ageing 33:34-41. 2004..to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom...
- Biochemical indicators of vitamin B12 and folate insufficiency and cognitive declineChristine C Tangney
Department of Clinical Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
Neurology 72:361-7. 2009....
- How common is vitamin B-12 deficiency?Lindsay H Allen
US Department of Agriculture, ARS Western Human Nutrition Research Center, University of California, Davis, Davis, CA 95616, USA
Am J Clin Nutr 89:693S-6S. 2009..However, intervention studies are still needed to assess efficacy and functional benefits of increasing intake of the amounts likely to be consumed in flour, including in elderly persons with varying degrees of gastric atrophy...
- Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanismsDaphna K Dror
Department of Nutrition at the University of California Davis, Davis, California, USA
Nutr Rev 66:250-5. 2008....
- Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified populationJoel G Ray
Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Epidemiology 18:362-6. 2007..Prior studies used relatively insensitive measures of B(12), did not adjust for folate levels, and were conducted in countries without folic acid food fortification. In Canada, flour has been fortified with folic acid since mid-1997...
- Megaloblastic anemia and other causes of macrocytosisFlorence Aslinia
Department of Internal Medicine, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA
Clin Med Res 4:236-41. 2006
- B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegansD Majchrzak
Department of Nutritional Sciences, University of Vienna, Vienna, Austria
Ann Nutr Metab 50:485-91. 2006..However, a vegetarian diet may be deficient in some nutrients. Exclusion of animal products in vegetarian diets may affect the status of certain B-vitamins, and further cause the rise of plasma homocysteine concentration...
- Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized studyCatharina Lewerin
Department of Medicine at the Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
Am J Clin Nutr 81:1155-62. 2005..Deficiencies of vitamin B-12, folic acid, and vitamin B-6-as defined by laboratory measures-occur in 10-20% of elderly subjects. The clinical significance remains unresolved...
- Plasma total homocysteine, folate, and vitamin B12 status in Korean adultsHyeon Sook Lim
Department of Food and Nutrition, Chonnam National University, Yongbong Dong, Buk gu Gwangju, 500 757, Korea
J Nutr Sci Vitaminol (Tokyo) 48:290-7. 2002..Our results indicate that male adults may be in worse condition for cardiovascular disease (CVD) than females. And improving folate and vitamin B12 status may reduce plasma tHcy level, which may be more important in males...
- Increased risk of cognitive impairment in patients with diabetes is associated with metforminEileen M Moore
Corresponding author Eileen M Moore
Diabetes Care 36:2981-7. 2013..To investigate the associations of metformin, serum vitamin B12, calcium supplements, and cognitive impairment in patients with diabetes...
- Low vitamin B-12 status and risk of cognitive decline in older adultsRobert Clarke
Clinical Trial Service Unit, University of Oxford, University of Oxford, Oxford, United Kingdom
Am J Clin Nutr 86:1384-91. 2007..Elevated total homocysteine (tHcy) concentrations have been associated with cognitive impairment, but it is unclear whether low vitamin B-12 or folate status is responsible for cognitive decline...
- Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicitiesCameron M Beech
Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Orphanet J Rare Dis 6:74. 2011..We present evidence that this founder mutation causes a substantial percentage of cases among diverse ethnicities and that the mutation is as old as human civilization...
- Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defectSeyit T Ceyhan
Department of Obstetrics and Gynecology, Gulhane Military Medical Academy, Ankara, Turkey
Gynecol Endocrinol 26:578-81. 2010..The aim of the study is to investigate the importance of serum vitamin B12 levels in pregnant women with foetal neural tube defect (NTD)...
- Update on vitamin B12 deficiencyRobert C Langan
St Luke s Hospital, Bethlehem, PA, USA
Am Fam Physician 83:1425-30. 2011....
- Evaluation of macrocytosisJoyce Kaferle
Department of Family Medicine, University of Michigan, Ann Arbor, Michigan, USA
Am Fam Physician 79:203-8. 2009..Of other possible etiologies, hypothyroidism, liver disease, and primary bone marrow dysplasias (including myelodysplasia and myeloproliferative disorders) are some of the more common causes...
- Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine StudyAnna Vogiatzoglou
OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Am J Clin Nutr 89:1078-87. 2009..Limited information is available on the association between vitamin B-12 status and intake from different dietary sources...
- Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child developmentAnne M Molloy
School of Medicine, Trinity College Dublin, Ireland
Food Nutr Bull 29:S101-11; discussion S112-5. 2008..However, the implications of starting pregnancy and lactation with low vitamin B12 status have not been sufficiently researched...
- Cobalamin status in childrenAnne Lise Bjørke-Monsen
Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
J Inherit Metab Dis 34:111-9. 2011..Cobalamin deficiency should be considered a differential diagnosis in children with subtle symptoms, and strategies to prevent cobalamin deficiency in mothers and children should be addressed...
- Vitamin B12 absorption: mammalian physiology and acquired and inherited disordersRenata Kozyraki
INSERM, U968, Paris F 75012, France
Biochimie 95:1002-7. 2013..Disturbed cellular entry, transit or egress of vitamin B12 may lead to low vitamin B12 status or deficiency and eventually hematological and neurological disorders...
- Juvenile selective vitamin B₁₂ malabsorption: 50 years after its description-10 years of genetic testingRalph Gräsbeck
Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki 00290, Finland
Pediatr Res 70:222-8. 2011..Clinical awareness must include attention to ethnicity, a sensitive topic but effective for fast diagnosis. The treatment with monthly parenteral Cbl for life offers a simple and cost-effective solution once proper diagnosis is made...
- Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate statusPrachi Katre
Kamalnayan Bajaj Diabetology Research Centre, King Edward Memorial Hospital Research Centre, Pune, India
Asia Pac J Clin Nutr 19:335-43. 2010..In vitamin B12 insufficient, folate replete pregnant women, vitamin B12 supplementation is associated with a reduction of plasma total homocysteine concentration in late pregnancy...
- Quantification of holo-transcobalamin, a marker of vitamin B12 deficiencyEbba Nexo
Department of Clinical Biochemistry, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
Clin Chem 48:561-2. 2002
- B12 deficiency: a look beyond pernicious anemiaEmmanuel Andres
Department of Internal Medicine, Diabetes and Metabolic Diseases, Hopitaux Universitaires de Strasbourg, Strasbourg, France
J Fam Pract 56:537-42. 2007
- Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B₁₂ status in the elderlyEdward Valente
Axis Shield Diagnostics, Dundee, UK
Clin Chem 57:856-63. 2011..Vitamin B₁₂ deficiency is common among the elderly, and early detection is clinically important. However, clinical signs and symptoms have limited diagnostic accuracy and there is no accepted reference test method...
- Inborn errors of cobalamin absorption and metabolismDavid Watkins
Department of Human Genetics, McGill University, Canada
Am J Med Genet C Semin Med Genet 157:33-44. 2011..Two other disorders, haptocorrin deficiency and transcobalamin receptor deficiency, have been described, but it is not clear that they have any consistent clinical phenotype...
- Low plasma vitamin B-12 in Kenyan school children is highly prevalent and improved by supplemental animal source foodsErin D McLean
Department of Nutritional Biology, University of California, Davis, CA 95616, USA
J Nutr 137:676-82. 2007..001). The high prevalence of low plasma vitamin B-12 concentrations in these children is predicted by a low intake of ASF, and supplemental ASF improves vitamin B-12 status...
- Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in IranZ Abdollahi
Family Health Department, Ministry of Health and Medical Education, Tehran University of Medical Science, Tehran, Iran
Ann Nutr Metab 53:143-50. 2008..Baseline data on folate and vitamin B(12) status are necessary before mandatory flour fortification is implemented...
- Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromesS Aaron
Neurology Unit, Department of Neurological Sciences, Christian Medical College, Vellore 632 004, Tamil Nadu, India
Neurol India 53:55-8; discussion 59. 2005..To study the clinical and laboratory features of patients admitted with vitamin B12 deficiency-related (B12def) neurological syndromes...
- Folate and vitamin B12 status of adolescent girls in northern NigeriaD J VanderJagt
Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131, USA
J Natl Med Assoc 92:334-40. 2000..We conclude that the adolescent girls we studied were at greater risk for vitamin B12 deficiency than folate deficiency. This conclusion is consistent with the fact that their diet included few foods that contained vitamin B12...
- Elevated serum methylmalonic acid concentrations are common among elderly AmericansMartha Savaria Morris
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 132:2799-803. 2002..We conclude that many elderly Americans demonstrate metabolic evidence of low B-12 status, that elevations occur frequently in the absence of traditional deficiency indicators and that levels vary with race/ethnicity and renal function...
- Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartumAnne L Morkbak
Dept of Clinical Biochemistry, Aarhus University Hospital, Aarhus Sygehus, Denmark
Haematologica 92:1711-2. 2007..The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy...
- Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalitiesR Carmel
Department of Medicine, New York Methodist Hospital, Brooklyn, NY, USA
Am J Clin Nutr 70:904-10. 1999..Low cobalamin concentrations and mild hyperhomocysteinemia are common in the elderly but ethnic differences have not been defined...
- Determination of serum holotranscobalamin concentrations with the AxSYM active B(12) assay: cut-off point evaluation in the clinical laboratoryFabrizia Bamonti
Dipartimento Scienze Mediche, Universita degli Studi di Milano, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Fondazione IRCCS, Milan, Italy
Clin Chem Lab Med 48:249-53. 2010..A reliable early marker is required for diagnosis of cobalamin deficiency. We calculated an appropriate holotranscobalamin (HoloTC) cut-off point for identifying cobalamin deficiency using an immunoenzymatic assay...
- Vitamin B12 deficiency and hyperhomocysteinemia in rural and urban IndiansC S Yajnik
Diabetes Unit, King Edward Memorial Hospital and Research Centre, Pune, India
J Assoc Physicians India 54:775-82. 2006..Low vitamin B12 concentration in South Asian Indians is common, but the exact prevalence is not known...
- Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategiesRalph Green
Department of Pathology, University of California, Davis, Sacramento, CA 95817, USA
Am J Clin Nutr 94:666S-72S. 2011..The general methods as well as their uses, indications, and limitations are presented...
- Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian IndiansH Refsum
Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway
Am J Clin Nutr 74:233-41. 2001..In India, most people adhere to a vegetarian diet, which may lead to cobalamin deficiency...
- Total homocysteine, vitamin B(12), and total antioxidant status in vegetariansW Herrmann
Department of Clinical Chemistry Central Laboratory, University Hospital of the Saarland, D 66421 Homburg Saar, Germany
Clin Chem 47:1094-101. 2001..We investigated vitamin B(12)-dependent metabolism and oxidative stress in groups with various or no intake of meat or animal products...
- Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trialSimone J P M Eussen
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Arch Intern Med 165:1167-72. 2005....
- Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalaminRasmus Beedholm-Ebsen
Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
Blood 115:1632-9. 2010..The identification of this Cbl export mechanism now allows the delineation of a coherent pathway for Cbl trafficking from food to the body cells...
- Neurologic complications of gastric bypass surgery for morbid obesityKatalin Juhasz-Pocsine
Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
Neurology 68:1843-50. 2007..Such procedures are not without complications, and those affecting the nervous system are often disabling and irreversible. We now describe our experience with these complications and review the pertinent literature...
- Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trialJolien de Jager
Department of Ophthalmology, Academic Medical Center, Amsterdam, Netherlands
BMJ 340:c2181. 2010....
- Vitamin B-12 and neural tube defects: the Canadian experienceMiles D Thompson
Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, Toronto, ON, Canada
Am J Clin Nutr 89:697S-701S. 2009..A multicenter randomized controlled trial comparing periconceptional vitamin B-12 in combination with FA against FA alone is warranted...
- The prevalence of vitamin B(12) deficiency in patients with type 2 diabetes: a cross-sectional studyMatthew C Pflipsen
Department of Primary Care, Raymond W Bliss Army Health Center, Ft Huachuca, AZ 85613, USA
J Am Board Fam Med 22:528-34. 2009..Metformin use and advanced age are associated with vitamin B(12) deficiency and often present in type 2 diabetic patients, yet the prevalence of vitamin B(12) deficiency in the diabetic population is unknown...
- Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood?John I Toohey
Cytoregulation Research, Elgin, Ontario, Canada KOG 1EO
Biofactors 26:45-57. 2006..The rearranged product is readily degraded to CH3-SH, providing a mechanism for removing toxic homocysteine...
- Quantification of methylmalonic acid in human plasma with hydrophilic interaction liquid chromatography separation and mass spectrometric detectionHans Ake Lakso
Department of Clinical Pharmacology, University of Umea, Umea, Sweden
Clin Chem 54:2028-35. 2008..We developed a method for quantifying MMA in plasma based on hydrophilic interaction liquid chromatography (HILIC) and single-stage negative electrospray ionization (ESI) mass spectrometry...
- Signs of impaired cognitive function in adolescents with marginal cobalamin statusM W Louwman
Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Netherlands
Am J Clin Nutr 72:762-9. 2000..38; 95% CI: -0.62, - 0.14). CONCLUSION: Our data suggest that cobalamin deficiency, in the absence of hematologic signs, may lead to impaired cognitive performance in adolescents...
- Genetically heterogeneous selective intestinal malabsorption of vitamin B12: founder effects, consanguinity, and high clinical awareness explain aggregations in Scandinavia and the Middle EastStephan M Tanner
Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Hum Mutat 23:327-33. 2004..We suggest that in both regions, physician awareness of this disease causes it to be more readily diagnosed than elsewhere; thus, it may well be more common worldwide than previously thought...
- Efficacy of oral cobalamin (vitamin B12) therapyEmmanuel Andres
Hôpital Civil Hôpitaux Universitaires de Strasbourg, Department of Internal Medicine, Diabetes and Metabolic Diseases, clinique médicale B, 1 Porte de l Hôpital, 67091 Strasbourg Cedex, France
Expert Opin Pharmacother 11:249-56. 2010..Management of cobalamin deficiency with cobalamin injections is well codified at present, but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption...
- Are hematinic deficiencies the cause of anemia in chronic heart failure?Klaus K A Witte
Division of Academic Cardiology, Castle Hill Hospital, Cottingham, United Kingdom
Am Heart J 147:924-30. 2004..We explored the relation between hematinic levels and hemoglobin (Hb) levels and exercise tolerance in a group of patients with CHF...
- Approaches to vitamin B12 deficiency. Early treatment may prevent devastating complicationsT S Dharmarajan
Division of Geriatrics, Our Lady of Mercy Medical Center, 4141 Carpenter Ave, Bronx, NY 10466, USA
Postgrad Med 110:99-105; quiz 106. 2001..If the disorder is untreated, complications may cause significant morbidity. In this article, Drs Dharmarajan and Norkus discuss approaches to screening and diagnosis as well as the nontoxic, low-cost treatments now available...
- Vitamin B12: chemistry and biochemistryB Krautler
Institute of Organic Chemistry, University of Innsbruck, A 6020 Innsbruck, Austria
Biochem Soc Trans 33:806-10. 2005..Microorganisms are the only natural sources of the B12-derivatives, whereas most spheres of life (except for the higher plants) depend on these cobalt corrinoids...
- Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant dietKatharine M Jones
Department of Nutrition, University of California, Davis, CA 95616, USA
J Nutr 137:1307-13. 2007..Vitamin B-12 supplementation of lactating women, food fortification, and education to improve infant's vitamin B-12 status are potential interventions that can improve the vitamin B-12 status of mothers and infants in this population...
- Independent effect of vitamin B12 deficiency on hematological status in older Chinese vegetarian womenT Kwok
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin
Am J Hematol 70:186-90. 2002..However, anemia associated with vitamin B(12) deficiency was seldom macrocytic. We recommend that older vegetarians should be given vitamin B(12) supplements routinely...
- Advances in the understanding of cobalamin assimilation and metabolismEdward V Quadros
Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Br J Haematol 148:195-204. 2010....
- Cobalamin and folate status in infants and young children in a low-to-middle income community in IndiaSunita Taneja
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
Am J Clin Nutr 86:1302-9. 2007..Population-based data on the prevalence of cobalamin and folate deficiency in India are lacking...
- Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategiesRalph Green
Department of Medical Pathology and Laboratory Medicine, University of California, Davis, California, USA
Food Nutr Bull 29:S52-63; discussion S64-6. 2008..The general methods as well as their uses, indications, and limitations are presented...
- Holotranscobalamin in laboratory diagnosis of cobalamin deficiency compared to total cobalamin and methylmalonic acidRima Obeid
Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
Clin Chem Lab Med 45:1746-50. 2007..Serum concentration of holoTC is a new marker in laboratory diagnosis of cobalamin deficiency. We tested the utility of holoTC in assessing vitamin B(12) status...
- Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered?G T Bondevik
Centre for International Health, University of Bergen, Bergen, Norway
Eur J Clin Nutr 55:856-64. 2001..The aim of this study was to investigate homocysteine and methylmalonic acid levels as markers of functional cobalamin and folate status in pregnant Nepali women...
- Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathyDavid S H Bell
Southside Endocrinology and Division of Diabetes, Endocrinology, and Metabolism, University of Alabama Medical School, Birmingham, AL 35205, USA
South Med J 103:265-7. 2010..To my knowledge, this is the first report of metformin-induced vitamin B12 deficiency causing neuropathy...
- Review of the magnitude of folate and vitamin B12 deficiencies worldwideErin McLean
Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland
Food Nutr Bull 29:S38-51. 2008..More representative data and more consistent use of thresholds to define deficiency are needed in order to assess whether folate and vitamin B12 deficiencies are a public health problem...
- Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcomeH Refsum
Department of Pharmacology, University of Bergen, Armauer Hansens Hus, 5021 Bergen, Norway
Br J Nutr 85:S109-13. 2001..This is followed by a brief discussion of some of the proposed mechanisms for their biological effects in relation to birth defects and pregnancy outcome...
- Increases in plasma holotranscobalamin can be used to assess vitamin B-12 absorption in individuals with low plasma vitamin B-12Dattatray S Bhat
Kamalnayan Bajaj Diabetology Research Centre, King Edward Memorial Hospital Research Centre, Pune, India
J Nutr 139:2119-23. 2009..Because malabsorption is unlikely to be a major reason for the low plasma vitamin B-12 concentrations in this population, increasing dietary vitamin B-12 should improve their status...
- Vitamin B12 deficiency - why refugee patients are at high riskJill Benson
Health in Human Diversity Unit, Discipline of General Practice, University of Adelaide, and Migrant Health Service, Tullawon Health Service Yalata Community, South Australia, Australia
Aust Fam Physician 39:215-7. 2010..Vitamin B12 is one of the most complex vitamins. The measurement of serum levels and the significance of the results are much debated in the literature...
- Prevalence of low serum folate and vitamin B12 in an older Australian populationVictoria M Flood
Department of Public Health, Centre for Vision Research, Westmead Millennium Institute, University of Sydney, New South Wales
Aust N Z J Public Health 30:38-41. 2006..To examine the prevalence of low serum folate and vitamin B12, in association with elevated serum homocysteine, in a representative sample of older Australians...
- Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epitheliumSANG WOON CHOI
Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
J Nutr 134:750-5. 2004..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis...
- Association between vitamin B12-containing supplement consumption and prevalence of biochemically defined B12 deficiency in adults in NHANES III (third national health and nutrition examination survey)Marian L Evatt
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30329, USA
Public Health Nutr 13:25-31. 2010..To explore the association between vitamin B(12) (B(12))-containing supplement use, low B(12) concentrations and biochemically defined B(12) deficiency in US adults...
- Cobalamin deficiency due to non-immune atrophic gastritis in elderly patients. A report of 25 casesN Henoun Loukili
Department of Internal Medicine, Diabetes and Metabolic Disorders, Hopitaux Universitaires de Strasbourg, France
J Nutr Health Aging 9:462. 2005
- Nutritional anemias and the elderlyRalph Carmel
Departments of Medicine, New York Methodist Hospital, 506 Sixth Street, Brooklyn, NY 11215, USA
Semin Hematol 45:225-34. 2008..Nutritional anemias usually feature abnormal MCV, whereas the predominant anemias in the aged, especially the anemias of chronic disease/chronic inflammation (ACD/ACI), of renal failure, and of unknown causes, are typically normocytic...
- Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patternsStephan M Tanner
Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Orphanet J Rare Dis 7:56. 2012..IGS and IFD differ in that IGS usually presents with proteinuria, which is not observed in IFD. The genetic heterogeneity and numerous differential diagnoses make clinical assessment difficult...
- Vitamin B12-responsive severe leukoencephalopathy and autonomic dysfunction in a patient with "normal" serum B12 levelsJ J Graber
Department of Neuro Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Neurol Neurosurg Psychiatry 81:1369-71. 2010....
- Partial characterization of cobalamin deficiency in Chinese Shar PeisMicah A Bishop
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4474, USA
Vet J 191:41-5. 2012..In conclusion, Shar Peis have a high prevalence of cobalamin deficiency compared to other breeds and healthy Shar Peis may have subclinical cobalamin deficiency...
- Hyperammonaemic encephalopathy secondary to selective cobalamin deficiency in a juvenile Border collieI A Battersby
Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU
J Small Anim Pract 46:339-44. 2005....
- [B12 vitamin deficiency and oral treatment. An option as efficient as (still) infrequently used]J E Mariño Suárez
Medico de Familia, Centro de Salud El Greco, Getafe, Madrid, Espana
Aten Primaria 32:382-7. 2003
- Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utilityEbba Nexo
Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
Am J Clin Nutr 94:359S-365S. 2011..To date, holoTC has not been used for population-based assessments of vitamin B-12 status, but we suggest that holoTC is a better marker than total vitamin B-12 for such studies...
- Prevalence of folate and vitamin B12 deficiency in Mexican children aged 1 to 6 years in a population-based surveyLucia Cuevas-Nasu
Instituto Nacional de Salud Publica, Morelos, Mexico
Salud Publica Mex 54:116-24. 2012..To describe the magnitude and distribution of folate and vitamin B12 deficiency in Mexican children...
- Vitamin B-12 metabolism in HIV-infected patients in the age of highly active antiretroviral therapy: role of homocysteine in assessing vitamin B-12 statusAngel F Remacha
Department of Hematology, Hospital de Sant Pau, Barcelona, Spain
Am J Clin Nutr 77:420-4. 2003..However, few patients had real vitamin B-12 deficiency...
- [Homozygous mutation in the intrinsic factor gene in a child with severe vitamin B12 deficiency]Tina Lund Leunbach
Børneafdelingen, Aarhus Universitetshospital, Aalborg Sygehus, 9000 Aalborg, Denmark
Ugeskr Laeger 173:2047-8. 2011..Gastroscopy with biopsies showed no pathology. All were given monthly cyanocobalamin injections which, however, caused leg cramps. Replacement with monthly hydroxocobalamin was successful...
- Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis StudyKatherine L Tucker
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
J Bone Miner Res 20:152-8. 2005..Men with plasma B12 < 148 pM had significantly lower BMD at the hip, and women at the spine, relative to those with higher B12, and trends were similar for both at all sites. Low vitamin B12 may be a risk factor for low BMD...
- LMBRD1: the gene for the cblF defect of vitamin B₁₂ metabolismFrank Rutsch
Department of General Pediatrics, Münster University Children s Hospital, Munster, Germany
J Inherit Metab Dis 34:121-6. 2011..These studies give further insight into the intracellular transport of vitamins, challenge the views on lipocalin receptors, and add to our understanding of lysosomal diseases...
- Proteinuria in cubilin-deficient patients with selective vitamin B12 malabsorptionVirve Wahlstedt-Fröberg
The Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
Pediatr Nephrol 18:417-21. 2003..The proteinuria was not of the classical glomerular or tubular type, but apparently due to the lack of cubilin function needed for tubular reabsorption of some, but not all, proteins of the primary urine...
- Diagnosing vitamin B-12 deficiency on the basis of serum B-12 assayVinod Devalia
Princess of Wales Hospital, Bridgend CF31 1RQ
BMJ 333:385-6. 2006
- Vitamin B-12 treatment has limited effect on health-related quality of life among individuals with elevated plasma methylmalonic acid: a randomized placebo-controlled studyA M Hvas
Department of Haematology, Aas, Aarhus University Hospital, Aarhus Kommunehospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
J Intern Med 253:146-52. 2003..To examine the hypothesis that treatment with vitamin B-12 improves health-related quality of life (HRQOL) in individuals with biochemical signs of vitamin B-12 deficiency...
- Periventricular white matter lucencies relate to low vitamin B12 levels in patients with small vessel strokeBarbe Pieters
Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands
Stroke 40:1623-6. 2009..Because vitamin B12 plays a role in maintaining the integrity of the blood-brain barrier, we studied serum vitamin B12 level in relation to such lesions...
- Metformin-associated vitamin B12 deficiencyEmmanuel Andres
Arch Intern Med 162:2251-2. 2002
- [Combined sclerosis of the spinal cord revealing vitamin B 12 deficiency: geriatric characteristics apropos of a case evaluated by MRI]O Beauchet
Service de Gerontologie Clinique, Hôpital de la Charité, CHU, 42055 Saint Etienne, France
Rev Med Interne 23:322-7. 2002..A subacute combined degeneration of the spinal cord accounts for only 10% of the neurological complications. Revealing forms of this myelopathy are exceptional, and were rarely documented by magnetic resonance imaging (MRI) study...
- Homozygous AMN mutation in hereditary selective intestinal malabsorption of vitamin B12 in JordanJamil R Al-Alami
Department of Biochemistry and Medical Laboratory Science, Jordan University of Science and Technology, Irbid, Jordan
Saudi Med J 26:1061-4. 2005..Several syndromes present with megaloblastic anemia such as congenital megaloblastic anemia due to intrinsic factor defect and juvenile megaloblastic anemia with proteinuria due to defects in the cubilin or the amnionless protein...
- Mandatory fortification of the food supply with cobalamin: an idea whose time has not yet comeRalph Carmel
Department of Medicine, New York Methodist Hospital, Brooklyn, NY, 11215, USA
J Inherit Metab Dis 34:67-73. 2011..Extensive work, especially randomized clinical trials, must be done before mandatory dietary intervention on a national scale can be justified...
- Comparing costs of intramuscular and oral vitamin B12 administration in primary care: a cost-minimization analysisJosep Vidal-Alaball
National Public Health Service for Wales, Swansea, Wales, UK
Eur J Gen Pract 12:169-73. 2006..To establish whether savings could be made by changing patients from intramuscular to high doses of oral vitamin B12 in primary care without compromising their wellbeing...
- Vitamin B12 deficiency in a 9-month-old boyChristine Quentin
Department of Hematology and Oncology, Universite Libre de Bruxelles, Queen Fabiola Children s Hospital, Brussels, Belgium
Eur J Pediatr 171:193-5. 2012..Therefore, evaluation of vitamin B12 status during pregnancy and lactation is necessary in order to prevent B12 deficiency and its possible long-term effects in infants...
- Juvenile cobalamin deficiency in a 17-year-old child with autonomic dysfunction and skin changesAbdul Hafeez Siddiqui
Department of Pediatrics, University of South Alabama College of Medicine, Mobile, AL, USA
J Pediatr Hematol Oncol 34:140-2. 2012..The expected macrocytosis was masked by an underlying alpha-thalassemia trait. The patient had an excellent response to parenteral cobalamin treatment...
- [Hereditary juvenile cobalamin deficiency due to mutations in GIF gene]M C Garcia Jimenez
Unidad de Metabolismo, Hospital Universitario Infantil Miguel Servet, Saragossa, Spain
An Pediatr (Barc) 69:56-8. 2008..The identification of disease-causing mutations in specific genes has improved our ability to diagnose many of these conditions...
- Oral cobalamin (vitamin B(12)) treatment. An updateE Andres
Department of Internal Medicine, Diabetes and Metabolic Diseases, Hopitaux Universitaires de Strasbourg, Strasbourg, France
Int J Lab Hematol 31:1-8. 2009..This present review confirms the previously reported efficacy of oral cobalamin treatment in adult and elderly patients...
- A finger-prick medical diagnostic for vitamin B12 malabsorption: An early intervSTEPHEN DUEKER; Fiscal Year: 2006..The work is significant as it would lead to a needed convenient diagnostic test for the clinical B12 malabsorption that can be employed in the clinic or in research settings. [unreadable] [unreadable] [unreadable]..
- A Novel Diagnostic Test To Detect Vitamin B12 DeficiencyDavid Wagner; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and BoneYu Xiao Yang; Fiscal Year: 2013....
- B12 Absorption, Kinetics and Transcobalamin GenotypeJoshua Miller; Fiscal Year: 2004..This novel method would ultimately replace the Schilling test, the current gold standard, but flawed and cumbersome method for clinical assessment of B 12 absorptive capacity. ..
- Rapid, Inexpensive Microchip Assay for HomocysteineDale Willard; Fiscal Year: 2009..This is because devices like ours offer cheaper testing, closer to the patient, reduction in healthcare costs, and enhancements the physician-patient dialog and thus improving care. ..
- TREATMENT OF AIDS VACUOLAR MYELOPATHY WITH METHIONINEAlessandro DiRocco; Fiscal Year: 2002..We request to complete the clinical trial and the metabolic observations of the study. ..
- EARLY URINE B12 DEFICIENCY DETECTION IN ELDERLYERIC NORMAN; Fiscal Year: 1990....
- FOLIC ACID REQUIREMENTS AND ONE CARBON METABOLISMBarry Shane; Fiscal Year: 2004....
- METABOLIC STUDIES IN DEMENTIA, AGING AND DEMYELINATIONSTUART SCHNECK; Fiscal Year: 1993..Core A provides clinical, neuropathological and statistical support while Core B provides administrative assistance...
- LIPOTROPE MEDIATED PROGRAMMED CELL DEATH IN MCF7 CELLSChung Park; Fiscal Year: 1999....
- A Novel Diagnostic Test To Detect Vitamin B12 DeficiencyDavid Wagner; Fiscal Year: 2003b>Vitamin B 12 deficiency is a common, but under diagnosed condition found primarily in the elderly. This deficiency mainly results from changes in the gastrointestinal tract that take place during aging and from certain medications...
- VITAMIN B12 DEFICIENCY IN RHESUS MONKEYSDIMITRIS AGAMANOLIS; Fiscal Year: 1980....
- SUBTLE DISTURBANCES OF COBALAMIN STATUSRalph Carmel; Fiscal Year: 2007..unreadable] [unreadable]..
- FOLATE DEFICIENCY DURING CANCER CHEMOTHERAPYMark Koury; Fiscal Year: 2000..abstract_text> ..
- Measurement of folate in fortified cereal grain productsJacob Selhub; Fiscal Year: 2003..In order to assess the impact of folic acid fortification, it is necessary to have valid data on the actual synthetic folic acid content of fortified foods. ..
- Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring StudyJacob Selhub; Fiscal Year: 2010..5 About 3-5 percent of seniors have low circulating vitamin B12 levels;6 however, about 20 percent of seniors are found to be deficient when those with elevated methylmalonic acid levels are included. ..
- FOOD FOLATE FORTIFICATION EFFECT ON FOLATE STATUSJacob Selhub; Fiscal Year: 2001..abstract_text> ..
- Vitamin B6, Vascular Dysfunction and Adhesion Molecules in Sickle Cell DiseaseRalph Green; Fiscal Year: 2010..The positive health impact of vitamin supplementation that could ameliorate the high morbidity and mortality associated with this disorder has the potential for high benefit with minimal cost and risk. ..
- Vitamin B12 Status of Elderly AmericansMARTHA MORRIS; Fiscal Year: 2003..The third aim is to evaluate the usefulness of a serum vitamin B12 cut-off point of 258 pmol/L, either as the sole indicator of vitamin B12 deficiency in the elderly, or in conjunction with anemia or an elevated metabolite level. ..
- B12 Nutrition in the AgedSally Stabler; Fiscal Year: 2007..This paradox is explained because many seniors continue to have undiagnosed and untreated vitamin B 12 deficiency as shown by elevated serum methylmalonic acid concentrations...
- Folate, DNA Methylation and Breast TumorigenesisJoshua Miller; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- VASCULAR EFFECTS OF HOMOCYSTEINE IN HUMANSWILLIAM HAYNES; Fiscal Year: 2005..The results may also suggest novel potential therapeutic approaches to be tested in future outcome trials. ..
- Helicobacter pylori: Pathogenesis and VirulenceKenneth Simpson; Fiscal Year: 2005....
- Center for Research/Nutrition & Health among the ElderlyKatherine Tucker; Fiscal Year: 2007..Three cores will work with all projects, including administrative, statistical and laboratory cores. A pilot grants program during years 2-4 will encourage additional investigations relevant to the Center theme. ..
- The Transcobalamin Receptor in Cobalamin HomeostasisEdward V Quadros; Fiscal Year: 2010..abstract_text> ..
- ZINC AND IRON SUPPLEMENTATION: IMPACT ON DEVELOPMENTMaureen Black; Fiscal Year: 2002..The results have important public health implications regarding the timing of micronutrient supplementation and the relationship between micronutrient deficiency and children's behavior and development. ..
- Homeostatic Regulation of Folate MetabolismPatrick J Stover; Fiscal Year: 2010..5. regulation of cSHMT by folate/choline preserves dTMP pools at the expense of AdoMet synthesis. The long-term goals of this project are: 1. to define homeostatic mechanisms used bv cells to regulate folate metabolism. ..
- Epigenetic effects of chronic alcohol consumption on colonic mucosaSANG WOON CHOI; Fiscal Year: 2007..If those studies can precisely define the epigenetic mechanism for alcohol-associated carcinogenesis, we can develop a new chemopreventive strategy for those cancers. [unreadable] [unreadable] [unreadable]..
- SELF-CARE IN SYMPTOM MANAGEMENT AT THE END OF LIFEKarolynn Siegel; Fiscal Year: 2002..Specifically we will investigate: 1) the symptom appraisal process; 2) coping responses to common symptoms: 3) the kinds of self-care activities employed; 4) emotional responses to common symptoms. ..
- EFFECTS OF SAM IN PATIENTS WITH ALCOHOLIC LIVER DISEASECharles Halsted; Fiscal Year: 2007..By confirming the relationship of abnormal methionine metabolism to clinical, biochemical, and pathologic disease severity, the study will establish a metabolic basis for determining the efficacy of SAM intervention in ALD. ..
- MSMW: Pathways, Motives and BehaviorsKarolynn Siegel; Fiscal Year: 2009..The study's finding will offer novel and important information about a high risk subpopulation of MSMW, and will yield important information that can guide the development of preventive interventions. ..
- Epidemiology of Recurrent Aphthous StomatitisLorena Baccaglini; Fiscal Year: 2007..Understanding the cause of canker sores can lead to better treatments for patients affected by this condition. [unreadable] [unreadable] [unreadable]..
- DBS Effects on Mood and Cognition in Parkinsons DiseaseMichael Okun; Fiscal Year: 2007..This proposal includes active and experienced mentoring, access to diverse resources, and a scientific environment suited specifically for the development of the PI as an independent physician scientist. ..
- Prenatal Drug Exposure: Effects on Adolescent Brain and Behavioral DevelopmentMaureen Black; Fiscal Year: 2009..This application examines adacemic performance, socio-emotional functioning, and drug use among adolescents exposed to cocaine and/or heroin prenatally ..
- HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTIONRoy Freeman; Fiscal Year: 2007..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
- 2007 International Peripheral Nerve Society Meeting at Snowbird, UtahA Smith; Fiscal Year: 2007..The meeting directly impacts public health and patient care by disseminating important new ideas (both research and therapeutic) and by developing consensus guidelines. [unreadable] [unreadable] [unreadable]..
- Toddler Feeding StylesMaureen M Black; Fiscal Year: 2010..abstract_text> ..
- The CASCADE Study: End-of-Life in Advanced DementiaSusan Mitchell; Fiscal Year: 2008..abstract_text> ..
- The ADEPT Study: Estimating Prognosis in Advanced DementiaSusan Mitchell; Fiscal Year: 2009..Thus, the information derived from this study has the potential to make important clinical, research and policy-relevant contributions to the care of older persons with dementia at the end-of-life. ..
- NUTRITIONAL BIOCHEMISTRY AND EPIDEMIOLOGY OF CANCERSteven Zeisel; Fiscal Year: 2006..We are requesting two postdoctoral and six predoctoral trainee positions each year for this purpose. ..
- Studies of Human Folate HydrolaseCharles Halsted; Fiscal Year: 2005..abstract_text> ..
- Oleic Acid Effects on Transit and Absorption in SBSCharlene Compher; Fiscal Year: 2004....
- HIV-Infected IDU Living with HCV CoinfectionKarolynn Siegel; Fiscal Year: 2005..abstract_text> ..
- Mood Disorders & Diabetes: Common Disease MechanismsWILLIAM REGENOLD; Fiscal Year: 2005..S. Such treatments could have the potential not only to provide symptom relief but also to repair and prevent the brain disease contributing to treatment resistance. ..
- Effect of hormonal contraception on bone mineral densityAbbey Berenson; Fiscal Year: 2005..Ultimately, this study will determine which women, if any, are placed at increased risk of osteopenia or osteoporosis as a result of using these hormonal contraceptives during their reproductive years. ..
- Postoperative dietary counseling after bariatric surgeryDAVID SARWER; Fiscal Year: 2005..Results of this study could have a significant impact on the postoperative care of these individuals. ..
- Tube-feeding in Elderly: Decision-making and OutcomesSusan Mitchell; Fiscal Year: 2003..By the end of the award period the applicant will have the skills, experience and research track record necessary to become an independent investigator and leader in academic geriatrics. ..
- Symptom Interpretation & Oral Health among Harlem AdultsKarolynn Siegel; Fiscal Year: 2005..In depth face-to-face, focused interviews will be conducted with 120 adults. As in several of the principal Investigator's previous federally funded investigations, qualitative research methods will be employed. ..
- Omega-3 Fatty Acids in the Treatment of DepressionDavid Mischoulon; Fiscal Year: 2005..It is hoped that this project will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator. ..
- A Novel Approach to Carbon-13 Breath TestsDavid Wagner; Fiscal Year: 2002..Our long-term objective is to use RID technology to develop a family of gastrointestinal stable isotope breath tests that are clinically useful and low cost. ..
- A NOVEL METHOD TO DETECT HELICOBACTER PYLORI IN CHILDRENDavid Wagner; Fiscal Year: 2004..The simplicity of the Ez-HBT(TM) including no test meal, a tablet that can be dissolved in a glass of water and a single traditional venipuncture makes it an ideal and cost effective tool for identifying H. pylori infection in children. ..
- A Novel Diagnostic Test for Irritable Bowel SyndromeDavid Wagner; Fiscal Year: 2002..abstract_text> ..
- Omega-3 Fatty Acids for Treatment of Major DepressionDavid Mischoulon; Fiscal Year: 2010..e. integrates biological findings with treatment in order to have a direct impact on the clinical practice of psychiatry. ..
- Implementation of Asthma Guidelines in Primary Care; Comparison of 4 approachesJames W Mold; Fiscal Year: 2010..If effective, the same strategies could be used to facilitate implementation of other chronic disease guidelines. ..
- A Breath Test to Detect Bacterial Overgrowth in ElderlyDavid Wagner; Fiscal Year: 2003..abstract_text> ..
- New DHFR Deletion Polymorphism - A Risk Factor for SB?William Johnson; Fiscal Year: 2003..Forms of foliate that are already reduced could be preferable as foliate supplements during pregnancy for prevention of SB. ..
- Gordon Research Sponsored Conference on CobalaminsRuma Banerjee; Fiscal Year: 2003....
- Effect of aging on folate metabolism in the colonSANG WOON CHOI; Fiscal Year: 2003....
- Nutritional Influences on Aresenic ToxicityMary Gamble; Fiscal Year: 2006..abstract_text> ..
- REGULATION OF FOLATE CATABOLISMPATRICK STOVER; Fiscal Year: 2007..2). to determine the risk that folate catabolism contributes to folate-associated pathologies. (3). to establish relationships between catecholamines and folate metabolism. ..
- Diethanolamine, brain development and adult memorySteven Zeisel; Fiscal Year: 2006..abstract_text> ..
- SAMe and Folate Deficiency in Alcoholic MircropigsCharles Halsted; Fiscal Year: 2006..While furthering understanding of interactions of methionine metabolites on pathways of liver injury, the project may establish novel approaches to the prevention and treatment of ALD. [unreadable] [unreadable] [unreadable]..
- Renal Transplantation, Homocysteine Lowering & CognitionIrwin Rosenberg; Fiscal Year: 2007..Demonstrating the cognitive benefits of lowering homocysteine may pave the way to nutritional modification of cognitive decline in RTRs and other high-risk groups and even in the general population. ..
- Obesity, Body Image and Weight MaintenanceDAVID SARWER; Fiscal Year: 2005..These studies have been selected to further develop my knowledge of the treatment of obesity, and the training program has been designed to facilitate my development as an independent investigator in the field of obesity. ..
- Plasma Markers of Dietry Intervention to Delay Cognitiv*JAE KANG; Fiscal Year: 2005..Importantly, results from the proposed grant will lay the groundwork for a future, large-scale comprehensive study to examine dietary interventions to delay cognitive function. ..
- Antenatal and preschool iron and zinc use and cognitionParul Christian; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIAChaim Hershko; Fiscal Year: 2001..abstract_text> ..
- Micronutrients, stroke and cognition in agingIrwin Rosenberg; Fiscal Year: 2006..abstract_text> ..
- Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly SubjectsChristopher H van Dyck; Fiscal Year: 2010..This Pilot Clinical Trial will provide essential preliminary data for a subsequent full-scale trial of guanfacine for prefrontally-mediated cognitive dysfunction in elderly subjects. ..
- FASEB Summer Conference: Folate, B12 and 1C MetabolismPATRICK STOVER; Fiscal Year: 2004..Similarly, the poster sessions also highlight the activities and needs of the younger participants. ..
- Vitamins, Breast Milk HIV Shedding and Child HealthEduardo Villamor; Fiscal Year: 2006..unreadable] [unreadable]..