vitamin d deficiency

Summary

Summary: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)

Top Publications

  1. doi Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 106:963-8. 2010
  2. ncbi Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  3. doi Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline
    Michael F Holick
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 96:1911-30. 2011
  4. pmc Vitamin D deficiency and risk of cardiovascular disease
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Circulation 117:503-11. 2008
  5. pmc The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    J Clin Endocrinol Metab 92:2017-29. 2007
  6. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
  7. ncbi Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California Los Angeles School of Medicine, 924 Westwood Boulevard, Los Angeles, CA 90024, USA
    Am J Clin Nutr 79:820-5. 2004
  8. pmc 25-hydroxyvitamin D levels and the risk of mortality in the general population
    Michal L Melamed
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann 615, Bronx, NY 10461, USA
    Arch Intern Med 168:1629-37. 2008
  9. ncbi Overview of general physiologic features and functions of vitamin D
    Hector F DeLuca
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1544, USA
    Am J Clin Nutr 80:1689S-96S. 2004
  10. ncbi Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Am J Clin Nutr 79:362-71. 2004

Detail Information

Publications347 found, 100 shown here

  1. doi Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 106:963-8. 2010
    ..We prospectively analyzed a large electronic medical records database to determine the prevalence of vitamin D deficiency and the relation of vitamin D levels to prevalent and incident CV risk factors and diseases, including ..
  2. ncbi Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  3. doi Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline
    Michael F Holick
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 96:1911-30. 2011
    The objective was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency.
  4. pmc Vitamin D deficiency and risk of cardiovascular disease
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Circulation 117:503-11. 2008
    ..A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking.
  5. pmc The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    J Clin Endocrinol Metab 92:2017-29. 2007
    ..When data were available to combine, meta-analyses were performed, and summary odds ratios (OR) are presented...
  6. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  7. ncbi Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California Los Angeles School of Medicine, 924 Westwood Boulevard, Los Angeles, CA 90024, USA
    Am J Clin Nutr 79:820-5. 2004
    ..Although the role of vitamin D in type 2 diabetes is well recognized, its relation to glucose metabolism is not well studied...
  8. pmc 25-hydroxyvitamin D levels and the risk of mortality in the general population
    Michal L Melamed
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann 615, Bronx, NY 10461, USA
    Arch Intern Med 168:1629-37. 2008
    ..However, whether low serum 25(OH)D levels are associated with mortality in the general population is unknown...
  9. ncbi Overview of general physiologic features and functions of vitamin D
    Hector F DeLuca
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1544, USA
    Am J Clin Nutr 80:1689S-96S. 2004
    ..This overview provides a brief description of the physiologic, endocrinologic, and molecular biologic characteristics of vitamin D. It also provides information on new selective analogs of 1alpha,25-dihydroyvitamin D3 for therapy...
  10. ncbi Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Am J Clin Nutr 79:362-71. 2004
    The purpose of this review is to put into perspective the many health benefits of vitamin D and the role of vitamin D deficiency in increasing the risk of many common and serious diseases, including some common cancers, type 1 diabetes, ..
  11. doi Global vitamin D status and determinants of hypovitaminosis D
    A Mithal
    Indraprastha Apollo Hospitals, Sarita Vihar, Delhi Mathura Road, 110044 New Delhi, India
    Osteoporos Int 20:1807-20. 2009
    ....
  12. doi Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
    Am J Kidney Dis 58:374-82. 2011
    b>Vitamin D deficiency, assessed as low 25-hydroxyvitamin D (25[OH]D) level, is highly prevalent in patients with chronic kidney disease (CKD) and is associated with various adverse health outcomes...
  13. pmc Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004
    Adit A Ginde
    Department of Emergency Medicine, University of Colorado Denver School of Medicine, Aurora, 80045, USA
    Arch Intern Med 169:626-32. 2009
    ..Vitamin D insufficiency is associated with suboptimal health. The prevalence of vitamin D insufficiency may be rising, but population-based trends are uncertain. We sought to evaluate US population trends in vitamin D insufficiency...
  14. doi Prevention of rickets and vitamin D deficiency in infants, children, and adolescents
    Carol L Wagner
    American College of Obstetrics and Gynecology
    Pediatrics 122:1142-52. 2008
    ..There are also concerns for vitamin D deficiency in older children and adolescents...
  15. ncbi High prevalence of vitamin D inadequacy and implications for health
    Michael F Holick
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
    Mayo Clin Proc 81:353-73. 2006
    ..The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health...
  16. ncbi Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications
    P Lips
    Department of Endocrinology, Institute for Endocrinology, Reproduction and Metabolism, EVM Institute, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    Endocr Rev 22:477-501. 2001
    b>Vitamin D deficiency is common in the elderly, especially in the housebound and in geriatric patients. The establishment of strict diagnostic criteria is hampered by differences in assay methods for 25-hydroxyvitamin D...
  17. ncbi Vitamin D deficiency: a worldwide problem with health consequences
    Michael F Holick
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, MA 02118, USA
    Am J Clin Nutr 87:1080S-6S. 2008
    b>Vitamin D deficiency is now recognized as a pandemic. The major cause of vitamin D deficiency is the lack of appreciation that sun exposure in moderation is the major source of vitamin D for most humans...
  18. doi Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
    b>Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD).
  19. doi Dose response to vitamin D supplementation in postmenopausal women: a randomized trial
    J Christopher Gallagher
    Bone Metabolism Unit, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
    Ann Intern Med 156:425-37. 2012
    ..Serum 25-hydroxyvitamin D (25-[OH]D) is considered the best biomarker of clinical vitamin D status...
  20. pmc Vitamin D deficiency in obese children and its relationship to glucose homeostasis
    Micah L Olson
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 97:279-85. 2012
    The aim of the study was to compare the prevalence of vitamin D deficiency in obese and non-overweight children in North Texas, to examine relationships between dietary habits and 25-hydroxyvitamin D [25(OH)D] level in obese children, and ..
  21. pmc Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation
    Matthias Wacker
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Nutrition, and Diabetes, Department of Medicine, Boston University Medical Center, 85 East Newton Street, M 1013, Boston, MA 02118, USA
    Nutrients 5:111-48. 2013
    ..showing that vitamin D plays a crucial role in a plethora of physiological functions and associating vitamin D deficiency with many acute and chronic illnesses including disorders of calcium metabolism, autoimmune diseases, some ..
  22. doi Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial
    Pamela R von Hurst
    Institute of Food, Nutrition and Human Health, Massey University, Private Bag 102 904, North Shore Mail Centre, Auckland, New Zealand
    Br J Nutr 103:549-55. 2010
    ..Optimal vitamin D concentrations for reducing IR were shown to be 80-119 nmol/l, providing further evidence for an increase in the recommended adequate levels. Registered Trial No. ACTRN12607000642482...
  23. ncbi Vitamin D3 and brain development
    D Eyles
    Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Brisbane, Queensland 4076, Australia
    Neuroscience 118:641-53. 2003
    ..Our findings would suggest that low maternal vitamin D(3) has important ramifications for the developing brain...
  24. ncbi Is vitamin D deficiency to blame for the asthma epidemic?
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 120:1031-5. 2007
    ..Coupled with inadequate intake from foods and supplements, this then leads to vitamin D deficiency, particularly in pregnant women, resulting in more asthma and allergy in their offspring...
  25. doi Prevalence and correlates of vitamin D deficiency in US adults
    Kimberly Y Z Forrest
    Department of Public Health and Social Work, Slippery Rock University of Pennsylvania, Slippery Rock, PA 16057, USA
    Nutr Res 31:48-54. 2011
    Mounting evidence suggests that vitamin D deficiency could be linked to several chronic diseases, including cardiovascular disease and cancer...
  26. pmc Resurrection of vitamin D deficiency and rickets
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, and Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Clin Invest 116:2062-72. 2006
    The epidemic scourge of rickets in the 19th century was caused by vitamin D deficiency due to inadequate sun exposure and resulted in growth retardation, muscle weakness, skeletal deformities, hypocalcemia, tetany, and seizures...
  27. pmc Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001-2004
    Juhi Kumar
    Children s Hospital at Montefiore, Bronx, New York, USA
    Pediatrics 124:e362-70. 2009
    ..To determine the prevalence of 25-hydroxyvitamin D (25[OH]D) deficiency and associations between 25(OH)D deficiency and cardiovascular risk factors in children and adolescents...
  28. ncbi Vitamin D levels and early mortality among incident hemodialysis patients
    M Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 72:1004-13. 2007
    b>Vitamin D deficiency is associated with cardiovascular disease, the most common cause of mortality in hemodialysis patients...
  29. doi Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality
    Harald Dobnig
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Arch Intern Med 168:1340-9. 2008
    ..This study aimed to determine whether endogenous 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels are related to all-cause and cardiovascular mortality...
  30. ncbi Vitamin D: A millenium perspective
    Michael F Holick
    Vitamin D Laboratory, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Cell Biochem 88:296-307. 2003
    ..1,25(OH)(2)D and its analogs have been developed for treating the hyperproliferative disease psoriasis. Vitamin D deficiency is a major unrecognized health problem...
  31. doi New insights about vitamin D and cardiovascular disease: a narrative review
    Cora McGreevy
    Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Ann Intern Med 155:820-6. 2011
    ..b>Vitamin D deficiency has been linked with hypertension, myocardial infarction, and stroke, as well as other cardiovascular-..
  32. pmc Vitamin D(3) in fat tissue
    Miriam Blum
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA, 02111, USA
    Endocrine 33:90-4. 2008
    ..Compatible with the long-standing concept that fat tissue is a storage site for vitamin D, fat tissue and serum vitamin D(3) concentrations were positively correlated...
  33. ncbi Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study
    M K Javaid
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Lancet 367:36-43. 2006
    ..We investigated the effect of maternal vitamin D status during pregnancy on childhood skeletal growth...
  34. doi Vitamin D deficiency and depression in adults: systematic review and meta-analysis
    Rebecca E S Anglin
    Department of Psychiatry and Behavioural Neurosciences, St Joseph s Hospital, 50 Charlton Avenue E, Hamilton, Ontario, Canada
    Br J Psychiatry 202:100-7. 2013
    There is conflicting evidence about the relationship between vitamin D deficiency and depression, and a systematic assessment of the literature has not been available.
  35. pmc Vitamin D levels, lung function, and steroid response in adult asthma
    E Rand Sutherland
    Department of Medicine, University of Colorado, Denver, Colorado, USA
    Am J Respir Crit Care Med 181:699-704. 2010
    ..Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma...
  36. pmc Maternal vitamin D status during pregnancy and child outcomes
    C R Gale
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Eur J Clin Nutr 62:68-77. 2008
    ..To investigate whether exposure to high maternal concentrations of 25(OH)-vitamin D in pregnancy poses any risk to the child...
  37. doi Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis
    Kelechi E Nnoaham
    Department of Public Health, Oxfordshire Primary Care Trust, Richard Building, Old Road Campus, Headington, Oxford OX3 7LG, UK
    Int J Epidemiol 37:113-9. 2008
    ..To explore the association between low serum vitamin D and risk of active tuberculosis in humans...
  38. ncbi Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
    Am J Clin Nutr 85:860-8. 2007
    ..Increased awareness of the importance of vitamin D to health has led to concerns about the prevalence of hypovitaminosis D in many parts of the world...
  39. doi Vitamin D deficiency in children and its management: review of current knowledge and recommendations
    Madhusmita Misra
    Pediatric Endocrine and Neuroendocrine Units, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pediatrics 122:398-417. 2008
    Given the recent spate of reports of vitamin D deficiency, there is a need to reexamine our understanding of natural and other sources of vitamin D, as well as mechanisms whereby vitamin D synthesis and intake can be optimized...
  40. ncbi Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy
    Michael F Holick
    Boston University School of Medicine, 715 Albany Street, M1013, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 90:3215-24. 2005
    ..To evaluate serum 25-hydroxyvitamin D [25(OH)D] concentrations and factors related to vitamin D inadequacy in postmenopausal North American women receiving therapy to treat or prevent osteoporosis...
  41. doi Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies
    Armin Zittermann
    Clinic for Thoracic and Cardiovascular Surgery, Heart Centre North Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany
    Am J Clin Nutr 95:91-100. 2012
    ..Low vitamin D status may increase mortality risk...
  42. pmc Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
    Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical implications...
  43. doi Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?
    John H Lee
    Mid America Heart Institute and University of Missouri, Kansas City, Missouri, USA
    J Am Coll Cardiol 52:1949-56. 2008
    b>Vitamin D deficiency is a highly prevalent condition, present in approximately 30% to 50% of the general population. A growing body of data suggests that low 25-hydroxyvitamin D levels may adversely affect cardiovascular health...
  44. pmc Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children
    John M Brehm
    Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, Pittsburgh, PA 15224, USA
    Am J Respir Crit Care Med 186:140-6. 2012
    ..Little is known about vitamin D and asthma in Puerto Ricans...
  45. pmc Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats
    Marianne Tare
    Department of Physiology, Monash University, Victoria 3800, Australia
    J Physiol 589:4777-86. 2011
    Increasing evidence links vitamin D deficiency and cardiovascular dysfunction in human adults...
  46. doi Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels
    J A Sugden
    Department of Clinical Pharmacology, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Diabet Med 25:320-5. 2008
    ..To test whether a single large dose of vitamin D2 can improve endothelial function in patients with Type 2 diabetes mellitus and low serum 25-hydroxyvitamin D levels...
  47. ncbi 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort
    Elina Hypponen
    Center for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford St, London, WC1N 1EH, UK
    Diabetes 57:298-305. 2008
    ..Physiological interactions between vitamin D and IGF-1 are reported; this is the first study to investigate their combined associations with metabolic syndrome prevalence...
  48. ncbi Prevalence of vitamin D deficiency among healthy adolescents
    Catherine M Gordon
    Division of Adolescent Young Adult Medicine, Children s Hospital Boston and Harvard Medical School, Boston, Mass 02115, USA
    Arch Pediatr Adolesc Med 158:531-7. 2004
    Although vitamin D deficiency has been documented as a frequent problem in studies of young adults, elderly persons, and children in other countries, there are limited data on the prevalence of this nutritional deficiency among healthy US ..
  49. pmc Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals
    Ling Lu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes Care 32:1278-83. 2009
    ..To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome in the Chinese population...
  50. doi Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice
    Jean Claude Souberbielle
    Laboratoire de Physiologie, CHU Necker, Paris, France
    Autoimmun Rev 9:709-15. 2010
    ..In addition, where data were limited to smaller clinical trials or epidemiologic studies, the panel made expert-opinion based recommendations...
  51. pmc Vitamin D status: measurement, interpretation, and clinical application
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
    Ann Epidemiol 19:73-8. 2009
    ..status and is often normal or even increased as the result of secondary hyperparathyroidism associated with vitamin D deficiency. Most experts agree that 25(OH)D of <20 ng/mL is considered to be vitamin D deficiency, whereas a 25(OH)..
  52. ncbi Vitamin D and bone mineral density status of healthy schoolchildren in northern India
    Raman K Marwaha
    Department of Endocrinology and Thyroid Research, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
    Am J Clin Nutr 82:477-82. 2005
    Current data on the prevalence of vitamin D deficiency in India are scarce.
  53. doi Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids
    Rolf Jorde
    Endocrinology Research Group, Institute of Clinical Medicine, University of Tromsø, and Medical Clinic, University Hospital of North Norway, 9038 Tromsø, Norway
    Prog Lipid Res 50:303-12. 2011
    ....
  54. ncbi Risk assessment for vitamin D
    John N Hathcock
    Council for Responsible Nutrition, Washington, DC 20036 5114, USA
    Am J Clin Nutr 85:6-18. 2007
    ..Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose > or = 250 microg/d (10,000 IU vitamin D3) supports the confident selection of this value as the UL...
  55. ncbi Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y
    Heike A Bischoff-Ferrari
    Division of Aging, The Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, 1620 Tremont Street, Boston, MA 02120, USA
    Am J Clin Nutr 80:752-8. 2004
    ..Vitamin D may improve muscle strength through a highly specific nuclear receptor in muscle tissue...
  56. doi Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial
    R Jorde
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    J Intern Med 264:599-609. 2008
    ....
  57. pmc Update in vitamin D
    John S Adams
    UCLA Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095 7358, USA
    J Clin Endocrinol Metab 95:471-8. 2010
    ....
  58. ncbi Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994
    Shanna Nesby-O'Dell
    Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta 30341 3717, USA
    Am J Clin Nutr 76:187-92. 2002
    ..African American women are at higher risk of vitamin D deficiency than are white women, but few studies have examined determinants of hypovitaminosis D in this population.
  59. doi Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer
    Pamela J Goodwin
    Mount Sinai Hospital, 1284 600 University Ave, Toronto, Ontario M5G 1X4, Canada
    J Clin Oncol 27:3757-63. 2009
    ..Such effects are biologically plausible given the presence of vitamin D receptors in breast cancer cells, which act as nuclear transcription factors to regulate gene activity...
  60. doi Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography
    Stefan Pilz
    Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    J Clin Endocrinol Metab 93:3927-35. 2008
    ..Vitamin D has been shown to influence cardiac contractility and myocardial calcium homeostasis...
  61. doi Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial
    Thomas Larsen
    Department of Medical Research, Holstebro Hospital, Holstebro, Denmark
    Am J Hypertens 25:1215-22. 2012
    ..living at northern latitudes diminished cholecalciferol synthesis in the winter increases the risk of vitamin D deficiency. We wanted to test the hypothesis that daily cholecalciferol supplementation in the winter lowers BP in ..
  62. ncbi An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men
    Ilkka Laaksi
    Department of Cell Biology and Anatomy, Medical School, University of Tampere, Tampere, Finland
    Am J Clin Nutr 86:714-7. 2007
    ..The data suggest that differences in the ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection...
  63. pmc Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial
    Arash Hossein-Nezhad
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 8:e58725. 2013
    Although there have been numerous observations of vitamin D deficiency and its links to chronic diseases, no studies have reported on how vitamin D status and vitamin D3 supplementation affects broad gene expression in humans...
  64. pmc 25-Hydroxyvitamin D levels and the risk of stroke: a prospective study and meta-analysis
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Stroke 43:1470-7. 2012
    Despite evidence suggesting that vitamin D deficiency may lead to elevated cardiovascular disease risk, results regarding the association of 25-hydroxyvitamin D (25[OH]D) levels with stroke risk are inconclusive...
  65. doi Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology
    M Peterlik
    Department of Pathophysiology, University of Medicine Vienna, Vienna, Austria
    Eur J Clin Nutr 63:1377-86. 2009
    ..Understanding the underlying molecular and cellular processes provides a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases worldwide...
  66. pmc Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies
    James D Finklea
    Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University, Atlanta, GA 30322, USA
    Adv Nutr 2:244-53. 2011
    ..Over the last few decades, vitamin D deficiency has increased in prevalence in adults and children...
  67. pmc Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study
    Ken M Kunisaki
    Pulmonary Section, Minneapolis Veterans Affairs Medical Center, Minnesota 55417, USA
    Am J Respir Crit Care Med 185:286-90. 2012
    ..We hypothesized that low blood levels of 25(OH)D in patients with chronic obstructive pulmonary disease (COPD) would be associated with an increased risk of acute exacerbations of COPD (AECOPD)...
  68. ncbi Vitamin D: evolutionary, physiological and health perspectives
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
    Curr Drug Targets 12:4-18. 2011
    ..Epidemiologic evidence and prospective studies have linked vitamin D deficiency with increased risk of many chronic diseases including autoimmune diseases, cardiovascular disease, deadly ..
  69. doi Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives
    G Muscogiuri
    Endocrinologia e Malattie del Metabolismo, Universita Cattolica, Rome, Italy
    Nutr Metab Cardiovasc Dis 22:81-7. 2012
    ..In addition, vitamin D deficiency is associated with increased risk of cardiovascular disease (CVD) and this may be due to the relationship ..
  70. doi Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease
    Adriana S Dusso
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Kidney Int 79:715-29. 2011
    ..Furthermore, a striking incidence of vitamin D deficiency occurs in kidney disease and associates more strongly than calcitriol deficiency with a higher risk for ..
  71. pmc Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus
    Lauren L Ritterhouse
    Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Ann Rheum Dis 70:1569-74. 2011
    b>Vitamin D deficiency is widespread and has been associated with many chronic diseases, including autoimmune disorders...
  72. doi Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity
    Andjela T Drincic
    Department of Medicine, Creighton University, Omaha, NE, USA
    Obesity (Silver Spring) 20:1444-8. 2012
    ..There is no evidence for sequestration of supplemental or endogenous cholecalciferol. Vitamin D replacement therapy needs to be adjusted for body size if desired serum 25(OH)D concentrations are to be achieved...
  73. doi Vitamin D and diabetes
    Tatiana Takiishi
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, UZ Gasthuisberg, O and N I Herestraat, Leuven, Belgium
    Endocrinol Metab Clin North Am 39:419-46, table of contents. 2010
    ..This article reviews the role of vitamin D in the pathogenesis of T1D and T2D, focusing on the therapeutic potential for vitamin D in the prevention/intervention of T1D and T2D as well as its complications...
  74. ncbi Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats
    Thomas H J Burne
    Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
    Behav Brain Res 154:549-55. 2004
    Rat experiments have shown that prenatal Vitamin D deficiency leads to altered neonatal brain morphology, cell density and neurotrophin expression...
  75. doi Maternal vitamin D status determines bone variables in the newborn
    H T Viljakainen
    Department of Applied Chemistry and Microbiology, Division of Nutrition, P O Box 66, University of Helsinki, FI 00014 Helsinki, Finland
    J Clin Endocrinol Metab 95:1749-57. 2010
    ..Maternal vitamin D status may program neonatal skeletal development. The objective here was to determine the association of mothers' vitamin D status with bone variables of their newborns...
  76. pmc Serum 25-hydroxyvitamin D levels among US children aged 1 to 11 years: do children need more vitamin D?
    Jonathan M Mansbach
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 124:1404-10. 2009
    ..Our objective was to determine the serum levels of 25-hydroxyvitamin D (25[OH]D) in a nationally representative sample of U.S. [corrected] children ages 1-11 [corrected] years...
  77. doi Vitamin D deficiency causes deficits in lung function and alters lung structure
    Graeme R Zosky
    Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia
    Am J Respir Crit Care Med 183:1336-43. 2011
    The prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease...
  78. ncbi Vitamin D fortification in the United States and Canada: current status and data needs
    Mona S Calvo
    Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20910, USA
    Am J Clin Nutr 80:1710S-6S. 2004
    ..Recent prospective intervention studies with higher vitamin D concentrations provided evidence of safety and efficacy for fortification of specific foods and use of supplements...
  79. doi Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis
    T Hagenau
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Osteoporos Int 20:133-40. 2009
    ..Serum 25(OH)D levels on average were 54 nmol/l, were higher in women than men, and higher in Caucasians than in non-Caucasians. There was no trend in serum 25(OH)D level with latitude. Vitamin D deficiency was widespread.
  80. doi Vitamin D deficiency: a global perspective
    Ann Prentice
    The Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom and Medical Research Council Keneba, Keneba, The Gambia
    Nutr Rev 66:S153-64. 2008
    The prevalence of clinical vitamin D deficiency (rickets and osteomalacia) is high in many parts of the world, and there is a resurgence of rickets among children of ethnic minority groups in Europe and Australasia...
  81. ncbi Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone
    C Brot
    Osteoporosis Research Clinic, Dep 545, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Br J Nutr 86:S97-103. 2001
    ..Sun exposure seemed to contribute the most. The overall prevalence of vitamin D deficiency (defined as serum ) was 7 %...
  82. pmc Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa
    Adrian R Martineau
    Division of Mycobacterial Research, National Institute of Medical Research, Mill Hill NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 108:19013-7. 2011
    b>Vitamin D deficiency is associated with susceptibility to tuberculosis (TB) in HIV-uninfected people in Europe, but it is not known whether such an association exists among HIV-infected people in subtropical Africa...
  83. ncbi High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India
    Alok Sachan
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Am J Clin Nutr 81:1060-4. 2005
    b>Vitamin D deficiency is prevalent in India, a finding that is unexpected in a tropical country with abundant sunshine. Vitamin D deficiency during pregnancy has important implications for the newborn and infant...
  84. pmc 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults
    Kristen L Jablonski
    Department of Integrative Physiology, University of Colorado, Boulder, Colo 80309, USA
    Hypertension 57:63-9. 2011
    ..Reduced vitamin D receptor and 1-α hydroxylase may be molecular mechanisms linking vitamin D insufficiency to endothelial dysfunction...
  85. pmc High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Nutr 137:447-52. 2007
    In utero or early-life vitamin D deficiency is associated with skeletal problems, type 1 diabetes, and schizophrenia, but the prevalence of vitamin D deficiency in U.S. pregnant women is unexplored...
  86. pmc Epidemic influenza and vitamin D
    J J Cannell
    Atascadero State Hospital, 10333 El Camino Real, Atascadero, CA 93422, USA
    Epidemiol Infect 134:1129-40. 2006
    ..Solar radiation triggers robust seasonal vitamin D production in the skin; vitamin D deficiency is common in the winter, and activated vitamin D, 1,25(OH)2D, a steroid hormone, has profound effects on ..
  87. ncbi High prevalence of low dietary calcium, high phytate consumption, and vitamin D deficiency in healthy south Indians
    Chittari V Harinarayan
    Departments of Endocrinology and Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
    Am J Clin Nutr 85:1062-7. 2007
    Data on the vitamin D status of the population in a tropical country such as India have seldom been documented. Vitamin D deficiency is presumed to be rare.
  88. pmc Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity
    Anne Thea McGill
    University of Auckland Human Nutrition Unit, University of Auckland, Auckland, New Zealand
    Nutr J 7:4. 2008
    ..In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se...
  89. ncbi Assessing the vitamin D status of the US population
    Elizabeth A Yetley
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 88:558S-564S. 2008
    ..Finally, non-Hispanic whites tend to have higher vitamin D status than do non-Hispanic blacks and Mexican Americans...
  90. ncbi The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation
    P Lips
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands, and Nottingham City Hospital, David Evans Medical Research Centre, UK
    J Intern Med 260:245-54. 2006
    ..A high prevalence of inadequacy has been reported in many studies but the prevalence of inadequacy amongst women with osteoporosis in different regions of the world has not been well characterized...
  91. doi Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes
    Yuen Fung Yiu
    Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Clin Endocrinol Metab 96:E830-5. 2011
    ..The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear...
  92. doi Old wine in new bottles: vitamin D in the treatment and prevention of tuberculosis
    Adrian R Martineau
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London E1 2AB, UK
    Proc Nutr Soc 71:84-9. 2012
    ..b>Vitamin D deficiency is common in patients with active TB, and several clinical trials have evaluated the role of adjunctive ..
  93. doi Vitamin D deficiency and supplementation and relation to cardiovascular health
    James L Vacek
    Mid America Cardiology, Division of Cardiovascular Medicine, University of Kansas Medical Center and Hospital, Kansas City, Kansas, USA
    Am J Cardiol 109:359-63. 2012
    Recent evidence supports an association between vitamin D deficiency and hypertension, peripheral vascular disease, diabetes mellitus, metabolic syndrome, coronary artery disease, and heart failure...
  94. doi Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D?
    H Amital
    Department of Medicine B and Centre for Autoimmune Diseases, Sheba Medical Centre, Affiliated to Tel Aviv University Tel Hashomer 52621, Israel
    Ann Rheum Dis 69:1155-7. 2010
    ..Low serum vitamin D concentrations have been reported in several autoimmune disorders...
  95. ncbi Vitamin D and disease prevention with special reference to cardiovascular disease
    Armin Zittermann
    Department of Cardio Thoracic Surgery, Heart Center North Rhine Westfalia, Ruhr University of Bochum, Bad Oeynhausen, Georgstrasse 11, 32545, Germany
    Prog Biophys Mol Biol 92:39-48. 2006
    ..As a consequence, legislation has to be changed to allow higher amounts of vitamin D in fortified foods and supplements...
  96. doi Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women
    M S M Ardawi
    Center of Excellence for Osteoporosis Research, King Abdulaziz University, P O Box No 20724, Jeddah, 21465, Saudi Arabia
    Osteoporos Int 22:463-75. 2011
    The various factors that may contribute to vitamin D deficiency or insufficiency were examined among healthy Saudi pre- and postmenopausal women...
  97. doi Widespread vitamin D deficiency in urban Massachusetts newborns and their mothers
    Anne Merewood
    Division of General Pediatrics, Boston Medical Center, 88 E Newton St, Vose 3, Boston, MA 02118, USA
    Pediatrics 125:640-7. 2010
    ..To determine vitamin D status and associated factors in a cohort of newly delivered infants and their mothers in Boston, Massachusetts...
  98. doi Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy
    Christian Markus Lange
    Klinikum der J W Goethe Universität Frankfurt am Main, Medizinische Klinik 1, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Hepatol 54:887-93. 2011
    Vitamin D is an important immune modulator and preliminary data indicated an association between vitamin D deficiency and sustained virologic response (SVR) rates in hepatitis C virus (HCV) genotype 1 patients...
  99. doi High prevalence of vitamin D deficiency in north Indian adults is exacerbated in those with chronic kidney disease
    Zulfikar Jabbar
    Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Nephrology (Carlton) 14:345-9. 2009
    ..Vitamin D is being increasingly recognized as an important player in disease. Hypovitaminosis D is widespread in chronic kidney disease (CKD) populations around the world. The vitamin D status of Indian CKD patients is not known...
  100. pmc Vitamin D in health and disease: current perspectives
    Ran Zhang
    AllergyMatters Ltd, 5a Kingston House Estate, Portsmouth Rd, Long Ditton Surrey, England KT6 5QG, UK
    Nutr J 9:65. 2010
    ..of the association of vitamin D with a spectrum of development, disease treatment and health maintenance, vitamin D deficiency is common...
  101. doi Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents
    Edgard E Delvin
    Department of Clinical Biochemistry, CHU Sainte Justine, Montreal, Canada
    J Nutr 140:987-91. 2010
    ..Although the observed associations between 25(OH)D concentrations and fasting glucose, and variables of lipid metabolism are modest, they may have a potential long-term impact on cardiovascular risk...

Research Grants76

  1. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013
    ..b>Vitamin D deficiency is a common problem among the elderly...
  2. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Vitamin D deficiency is much more common in African Americans than whites...
  3. Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    ANNE LOUISE SCHAFER; Fiscal Year: 2013
    ..b>Vitamin D deficiency due to obesity and post-surgical malabsorption may partially explain the decline in bone mass observed ..
  4. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..The current modalities for treatment of COPD are limited, and prevalence of vitamin D deficiency is high...
  5. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    ..c) electron beam radiation, d), adriamycin induced fatigue (naloxone reversibility), e) crosstalk/impact of vitamin D deficiency, and f) optimization of naltrexone schedule/dosing...
  6. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2013
    ..b>Vitamin D deficiency can result in osteomalacia, where the mineral composition and bone tissue volume are both decreased...
  7. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2011
    ..b>Vitamin D deficiency can result in osteomalacia, where the mineral composition and bone tissue volume are both decreased...
  8. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..We hypothesize that obesity-induced inflammatory phenotype of epicardial fat is exacerbated by vitamin D deficiency leading to endothelial dysfunction and enhanced intimal hyperplasia following coronary intervention...
  9. Maternal-fetal vitamin D status and child adiposity, insulin resistance and BP
    Susanna Y Huh; Fiscal Year: 2010
    ..Epidemiologic data in adults suggest that vitamin D deficiency is related to obesity, type 2 diabetes, and hypertension...
  10. Classical and non-classical responses to vitamin D in children: the role of DBP g
    Thomas O Carpenter; Fiscal Year: 2010
    ..minorities) with either low or normal circulating 25-hydroxyvitamin D (25-OHD) levels, and have found that vitamin D deficiency (circulating 25-OHD <20 ng/ml) occurs in 13% of over 750 6 mo...
  11. Vitamin D and Vascular Function in Obese Children
    Kumaravel Rajakumar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vitamin D deficiency is emerging as an independent risk factor for subclinical vascular dysfunction, metabolic syndrome, and later cardiovascular disease (CVD) in children...
  12. VITAMIN D DEFICIENCY, INSULIN RESISTANCE AND CARDIOVASCULAR DISEASE
    Carlos Bernal-Mizrachi; Fiscal Year: 2013
    ..We hypothesize that vascular inflammation induced by vitamin D deficiency elevates blood pressure, diminishes arteriovascular flow, and promotes atherosclerosis in diabetes...
  13. PTH-RELATED PEPTIDE AND VIT D IN PROSTATE CANCER GROWTH
    Miriam Falzon; Fiscal Year: 2009
    ..b>Vitamin D deficiency is a risk factor for prostate cancer, and 1,25-dihydroxyvitarhin D3 (1,250, the hormonally active form of ..
  14. Vitamin D and fibroblast growth factor 23 physiology in adolescent girls
    DEBORAH MICHELLE MITCHELL; Fiscal Year: 2012
    ..30 pre-pubertal and early-pubertal girls with vitamin D deficiency (25OHD level 20 ng/mL) will be co-enrolled in a prospective, randomized, placebo-controlled trial and ..
  15. Vitamin D Deficiency in Glomerular Disease
    Michelle Denburg; Fiscal Year: 2013
    ..Her research is focused on the extra-skeletal actions of vitamin D and the unique challenges of managing vitamin D deficiency in patients with glomerular diseases complicated by nephrotic-range proteinuria...
  16. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..We recently showed that vitamin D deficiency is independently associated with a higher prevalence of anemia in the elderly, particularly among those ..
  17. Biological &Environmental Mediators of Vitamin D and Aggressive Prostate Cancer
    ADAM BRYANT MURPHY; Fiscal Year: 2013
    ..In several epidemiologic studies, vitamin D deficiency is associated with increased risk of prostate cancer and in some studies, aggressive disease...
  18. Randomized trial of active vitamin D, cholecalciferol and placebo for CKD-MBD
    Sharon M Moe; Fiscal Year: 2011
    ..In addition, there is increasing data that vitamin D deficiency may be associated with increased risk of multiple diseases and mortality, unrelated to its effects on bone ..
  19. Vitamin D deficiency and treatment in male veterans at risk for diabetes
    Elena Barengolts; Fiscal Year: 2013
    ....
  20. Non-Classical Manifestations of Primary Hyperparathyroidism
    Shonni J Silverberg; Fiscal Year: 2013
    ..The themes and Specific Aims (SA's) of this research are: Theme 1. Vitamin D deficiency in PHPT: SA1a...
  21. Milk osteopontin, a nutritional therapeutic intervention for alcoholic hepatitis
    Natalia Nieto; Fiscal Year: 2013
    ..Key events for the onset and progression of alcoholic hepatitis result from the gut-to-liver interaction. Vitamin D deficiency is highly prevalent in patients with alcoholic hepatitis...
  22. VITAMIN D AND IMMUNOMODULATION IN CORONARY ARTERY DISEASE
    Devendra K Agrawal; Fiscal Year: 2013
    ..restenoses following balloon angioplasty/stent implantation correlates well with the incidence of vitamin D deficiency/insufficiency...
  23. Impact of disordered mineral metabolism on stroke and cognitive impairment
    ORLANDO M GUTIERREZ; Fiscal Year: 2013
    ..Thus, if vitamin D deficiency and excess FGF23 are risk factors for cerebrovascular disease, this would support intervention trials ..
  24. MODifiable Effectors of Renin System Activation: Treatment Evaluation
    John P Forman; Fiscal Year: 2013
    ..Overweight or obese adults with vitamin D deficiency or uric acid levels e 5 mg/dL will be enrolled, and the primary endpoint will be the activation state of ..
  25. A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline
    Jae H Kang; Fiscal Year: 2013
    ..to Essence magazine, and others;African-Americans will be oversampled, as they have a higher prevalence of vitamin D deficiency. Respondents will be enrolled in a 3-month placebo run-in phase to test participation...
  26. Biological and Environmental modifiers of Vitamin D3 and Prostate Cancer Risk
    RICK ANTONIUS KITTLES; Fiscal Year: 2013
    ..These studies support the hypothesis that vitamin D deficiency increases the risk of Pca and that vitamin D is a potential chemopreventive and therapeutic agent...
  27. Vitamin D and Clinical Outcomes in Chronic Hemodialysis Patients
    MICHEL BENJAMIN CHONCHOL; Fiscal Year: 2012
    ..We therefore propose to explore the role of vitamin D deficiency as a non-traditional CVD risk factor...
  28. MOLECULAR PATHOGENESIS OF HYPERPARATHYROIDISM
    Andrew Arnold; Fiscal Year: 2012
    ..a parathyroid-targeted mutant cyclin D1 transgene unable to activate cdk4 or 6, and (b) examine whether vitamin D deficiency directly alters the growth of cyclin D1-induced parathyroid tumors and modulates the phenotype of primary ..
  29. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..We have shown that vitamin D deficiency is pervasive among black women throughout pregnancy and is significantly less common among white women...
  30. The effects of 1,25(OH)2D3 on the tumorigenesis of lung squamous cell carcinoma
    SARAH ANNE MAZZILLI; Fiscal Year: 2012
    ..In addition, vitamin D deficiency is associated strongly with the increased risk and poor prognosis of lung cancer...
  31. Vitamin D status, Gene Polymorphism and Breast Cancer Progression/Prognosis
    Xiao Ou Shu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Project Summary/Abstract) The association of vitamin D deficiency, or low levels of circulating vitamin D, with increased risk for cancers, including breast cancer (BC), has received extensive ..
  32. RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMA
    Scott T Weiss; Fiscal Year: 2013
    ..b>Vitamin D deficiency is highly prevalent among pregnant women, and thus, represents a potentially modifiable factor for the ..
  33. RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMA
    Robert Strunk; Fiscal Year: 2013
    ..b>Vitamin D deficiency is highly prevalent among pregnant women, and thus, represents a potentially modifiable factor for the ..
  34. Nutritional Intervention for Age-Related Muscular Function and Strength Losses
    John A Rathmacher; Fiscal Year: 2010
    ..Since a significant portion of the older population is at risk of having a Vitamin D deficiency, a product that corrects such deficiencies and specifically targets muscle strength, function, and mass is ..
  35. Functional Vitamin D Receptor Gene Variants and Racial/Ethnic Cancer Disparities
    Robin Taylor Wilson; Fiscal Year: 2010
    ..contributors to serum vitamin D levels, this research will assist important public health efforts to reduce vitamin D deficiency and health disparities related to vitamin D...
  36. HIGH-DOSE VITAMIN D AND ANTIMICROBIAL PEPTIDE EXPRESSION IN LUNG FAILURE
    Thomas R Ziegler; Fiscal Year: 2012
    ..shows that critically ill patients have an extremely high prevalence of vitamin D insufficiency and frank vitamin D deficiency. Unfortunately, regimens of vitamin D repletion in this setting have not been explored...
  37. Cyclin D1 and vitamin D signaling in oral keratinocyte pathophysiology
    Sanjay M Mallya; Fiscal Year: 2013
    ..examine the mechanism by which cyclin D1 deregulates vitamin D signaling and (2) examine role of dietary vitamin D deficiency in modulating the development of oral pre-cancer and cancer...
  38. Vitamin D, Metabolic Flux and Breast Cancer
    JoEllen Welsh; Fiscal Year: 2013
    ..breast cancer using dietary manipulation to induce a wide range of serum 25D levels representative of human vitamin D deficiency, sufficiency and excess...
  39. Vitamin D Deficiency Augments Renin-Angiotensin System Activity in Obesity
    Anand Vaidya; Fiscal Year: 2011
    ..Specific Aims: Vitamin D deficiency increases endogenous RAS activity;measured as a blunted blood pressure (BP) and renal blood flow (RBF) ..
  40. Impact of Vitamin D on Diabetic Kidney Disease in African Americans
    VANESSA ASTRUD DIAZ; Fiscal Year: 2012
    ..Based on animal and observational studies, vitamin D deficiency is potentially a novel, modifiable risk factor that may interrupt or delay the progression of diabetic ..
  41. Phosphorus and Vitamin D Metabolism and Cardiovascular Outcomes: The MESA Study
    Bryan R Kestenbaum; Fiscal Year: 2013
    ..higher concentrations of serum phosphorous, serum fibroblast growth factor-23, and urine phosphorous) and vitamin D deficiency (lower 25- hydroxyvitamin D and higher parathyroid hormone concentrations) will be associated with incident ..
  42. Epidemiology of Breast Cancer Subtypes in African American Women: a Consortium
    Julie R Palmer; Fiscal Year: 2013
    ..sunlight (high skin pigmentation), but that in western society may result in hyper-inflammatory milieu and vitamin D deficiency, which may be related to early, aggressive breast cancer...
  43. Vitamin D Intervention and Atherosclerosis Progression in African American Women
    Howard N Hodis; Fiscal Year: 2013
    ..The possibility of a causal link between vitamin D deficiency and CVD is supported by many studies as well as strong biological plausibility...
  44. Mechanisms of Hypovitaminosis D Pain: Role of Nociceptor Sprouting.
    SARAH ELIZABETH TAGUE; Fiscal Year: 2010
    ..The working hypothesis of this project is that a vitamin D deficiency leads to nociceptor hyperinnervation of tissue, altering pain threshold...
  45. Patient Oriented Research in Vitamin D Deficiency in CKD
    MARY BETH LEONARD; Fiscal Year: 2013
    ..Improved strategies for the prevention of CKD are urgently needed. Vitamin D deficiency may contribute directly to kidney damage by promoting inflammation and fibrosis, and accelerating podocyte ..
  46. TRAINING GRANT IN ACADEMIC ENDOCRINOLOGY
    PHILIP REED LARSEN; Fiscal Year: 2013
    ....
  47. Treatment of Vitamin D Insufficiency
    Karen E Hansen; Fiscal Year: 2013
    ..b>Vitamin D deficiency, defined as a serum 25(OH)D <15 ng/mL, contributes to osteoporosis via decreased calcium absorption (..
  48. Vitamin D3 Metabolism and Colorectal Cancer: Correlating Phenotype to Genotype
    Josephia R Muindi; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Vitamin D deficiency and its relationship to cancer and other chronic diseases is an important and growing public health problem...
  49. Vitamin D deficiency and the severity of bronchiolitis
    Jonathan M Mansbach; Fiscal Year: 2012
    ..goals of: 1) becoming a national leader of bronchiolitis research;2) understanding the association between vitamin D deficiency and severity of bronchiolits;and 3) becoming an independent patient-oriented investigator, Dr Mansbach ..
  50. BIOMEDICAL ANALYSIS OF HUMAN BIOSPECIMENS FOR DIPHR
    ERIN ALLEN; Fiscal Year: 2013
    ..Several studies have shown that . women with vitamin D deficiency during pregnancy tend to have infants with lower birth weight, although the evidence is still controversial...
  51. The Role of Vitamin D in Retinal Diseases in Aging
    AMY ELIZABETH MILLEN; Fiscal Year: 2013
    ..b>Vitamin D deficiency and inadequacy is prevalent in a large portion of the aging US population, and vitamin D has been shown to ..
  52. Dysregulated Mineral Metabolism in Acute Kidney Injury
    David E Leaf; Fiscal Year: 2013
    ..as hypocalcemia, hyperphosphatemia, hyperparathyroidism, elevated Fibroblast Growth Factor-23 (FGF23), and vitamin D deficiency are also observed in AKI...
  53. Vitamin D, cerebrovascular risk, and neurocognitive decline: ARIC Brain MRI Study
    Erin D Michos; Fiscal Year: 2013
    ..infarcts and WMH progression through identification of modifiable risk factors (such as potentially vitamin D deficiency) could reduce disability among older adults...
  54. Vitamin D Production by Sperti Lamp in Fat Malabsorption Patients
    JAMES GAMBLE SHEPHERD; Fiscal Year: 2010
    ..b>Vitamin D deficiency and insufficiency is the most common nutritional deficiency and medical condition in children and adults ..
  55. Molecular Basis of Childhood Asthma Following Perinatal Vitamin D Deficiency
    Virender K Rehan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): There are strong epidemiologic data suggesting a link between vitamin D deficiency during pregnancy and childhood asthma...
  56. 2012 Teratology Society Annual Meeting - Student/New and Early Stage Investigator
    JOHN MATTHEWSON GRAHAM; Fiscal Year: 2012
    ..maternal/fetal health in developing countries, effects of nuclear disasters on development, impact of Vitamin D deficiency on development, international regulatory controversies concerning maternal and fetal health, and novel ..
  57. Adjunct vitamin D therapy as a means to reduce the disparity in subclinical targe
    PHILLIP DAVID LEVY; Fiscal Year: 2013
    ..Like cardiovascular disease, vitamin D deficiency disproportionately affects African-Americans...
  58. Vitamin D supplementations as adjunct to anti-tuberculosis drugs in Mongolia
    Ganmaa Davaasambuu; Fiscal Year: 2013
    ..Relevance: Tuberculosis is one of the priorities in global health. Vitamin D deficiency is prevalent almost everywhere, both in developed and developing countries, the full potential of vitamin D ..
  59. Optimizing Vitamin D Treatment in HIV/AIDS: An RCT
    DOUGLAS THOMAS DIETERICH; Fiscal Year: 2013
    ..This project addresses the need for a validated protocol for treating vitamin D deficiency in HIV- positive individuals on HAART...
  60. EARLY LIFE VITAMIN D, RACIAL DISPARITIES, AND WHEEZING
    GANESA REBECCA WEGIENKA; Fiscal Year: 2013
    ..Further, there is an epidemic of vitamin D deficiency caused by changes in lifestyles in westernized cultures, including the United States, which ..
  61. Predicting Systemic Autoimmunity through Follow-up of Blood Relatives
    Judith A James; Fiscal Year: 2010
    ..Additional lupus- associated environmental factors, such as markers of vitamin D deficiency and abnormal humoral immune responses to common pathogens, will be tested as predictors of SLE disease ..
  62. Maternal Vitamin D Status and Preterm Birth
    Lisa M Bodnar; Fiscal Year: 2013
    ..We have shown that 3 vitamin D deficiency is pervasive among pregnant black women and is significantly less common among white 4 women...
  63. Prevention of Vitamin D Deficiency in Breastfed Infants
    Ekhard Ziegler; Fiscal Year: 2009
    b>Vitamin D deficiency occurs among breastfed infants in all parts of the U.S. but is particularly common among infants with dark skin pigmentation and infants living in the northern parts of the U.S...
  64. Vitamin D status in pregnant women
    Theresa Scholl; Fiscal Year: 2009
    ..If vitamin D deficiency is a risk factor for any or all of these problems then the underlying cause will have been uncovered and ..
  65. REGULATION OF PARATHYROID HORMONE AND CALCITONIN GENES
    Justin Silver; Fiscal Year: 1991
    ..vivo will be studied: (a) priming doses given to normal rats and rats with parathyroid hyperplasia due to vitamin D deficiency or chronic renal failure, (b) the kinetics of hormone withdrawal, (c) interaction with glucocorticoids ..
  66. EFFECTS OF VITAMIN D DEFICIENCY ON MALE REPRODUCTION
    GARY KWIECINSKI; Fiscal Year: 1992
    ..sites and mechanisms of action of vitamin D that are responsible for the reduced fertility observed in vitamin D deficiency. That normal reproductive functions are vitamin D-dependent was a novel finding with direct implications ..
  67. Regulation of minerals and fluids excretion in vitamin D
    Yan Chun Li; Fiscal Year: 2005
    ..extensive training on general physiology of the vitamin D endocrine system and the pathophysiology of vitamin D deficiency, particularly, in the area of vitamin D regulation of mineral metabolism...
  68. GLUCOCORTICOID-INDUCED OSTEOPENIA IN CHILDREN
    Mary Leonard; Fiscal Year: 2005
    ..exacerbated by the effects of the underlying disease, such as delayed growth and maturation, malnutrition, vitamin D deficiency and increased bone resorption by inflammatory cytokines...
  69. Genetic Variation in Vitamin D Metabolism and BMT Outcomes
    KIMBERLY ROBIEN; Fiscal Year: 2009
    ..Little is known about vitamin D status during BMT, although there is reason to believe that vitamin D deficiency is common...
  70. Vitamin D Control of TGFa/EFG Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2006
    ..While it is known that hypocalcemia, hyperphosphatemia, and vitamin D deficiency promote parathyroid (PT) hyperplasia in renal failure, the underlying mechanisms are poorly understood...
  71. Ultraviolet Light Devices for Vitamin D
    HENRY SAVAGE; Fiscal Year: 2003
    b>Vitamin D deficiency is now recognized as a significant health problem for middle-aged and older adults. Vitamin D deficiency exacerbates osteoporosis and causes the bone disease, osteomalacia...
  72. Role of Microstructure in Nanomechanical Behavior of Bone Tissue
    Marjolein C van der Meulen; Fiscal Year: 2010
    ..Our approach will cross-correlate several microlevel techniques that have not been previously used to characterize bone tissue mechanics. ..
  73. THE TRANSPORT OF CALCIUM
    David Schachter; Fiscal Year: 1991
    ..The molecular functions of IMCAL will be explored by modulating the tissue content in vivo (vitamin D deficiency versus repletion; low versus high calcium diets), isolating membrane vesicles (microvillus membranes and ..
  74. Vitamin D Deficiency, Physical Performance and Cardiovascular Outcomes in CRIC
    Mary Leonard; Fiscal Year: 2009
    ..Numerous observational studies, clinical trials and animal studies have demonstrated that vitamin D deficiency in the absence of CRI is associated with muscle weakness, hypertension and left ventricular hypertrophy (..
  75. Contemporary Diagnosis and Treatment of Vitamin D-Related Disorders
    Marc Drezner; Fiscal Year: 2006
    ..Bio-medical advances have lowered the incidence of the index diseases traditionally associated with vitamin D deficiency, rickets and osteomalacia...
  76. REGULATION OF EPIDERMAL STEROL METABOLISM IN AGING
    D Pehlke; Fiscal Year: 1980
    ..Patients with clinically evident xerosis and with mild vitamin D deficiency associated with osteoporosis will also be studied in an effort to clarify the pathophysiology of these ..