hyponatremia

Summary

Summary: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)

Top Publications

  1. ncbi Hyponatremia treatment guidelines 2007: expert panel recommendations
    Joseph G Verbalis
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
    Am J Med 120:S1-21. 2007
  2. ncbi A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia
    Salvatore Anfuso
    Department of Gynecology, Obstretrics and Neonatology, University of Parma, University Hospital of Parma, Italy
    Acta Biomed 80:73-6. 2009
  3. ncbi Hyponatremia and mortality among patients on the liver-transplant waiting list
    W Ray Kim
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 359:1018-26. 2008
  4. pmc Mortality and serum sodium: do patients die from or with hyponatremia?
    Arun Chawla
    Division of Nephrology and Hypertension, Hofstra North Shore LIJ School of Medicine, Great Neck, New York, USA
    Clin J Am Soc Nephrol 6:960-5. 2011
  5. pmc Hyponatremia, hypernatremia, and mortality in patients with chronic kidney disease with and without congestive heart failure
    Csaba P Kovesdy
    Division of Nephrology, Salem Veterans Affairs Medical Center, 1970 Roanoke Blvd, Salem, VA 24153, USA
    Circulation 125:677-84. 2012
  6. ncbi Impact of hospital-associated hyponatremia on selected outcomes
    Ron Wald
    St Michael s Hospital and University of Toronto, and Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Arch Intern Med 170:294-302. 2010
  7. pmc Three independent biological mechanisms cause exercise-associated hyponatremia: evidence from 2,135 weighed competitive athletic performances
    T D Noakes
    University of Cape Town Medical Research Council Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town Sports Science Institute of South Africa, Newlands, 7700, South Africa
    Proc Natl Acad Sci U S A 102:18550-5. 2005
  8. ncbi Mild hyponatremia as a risk factor for fractures: the Rotterdam Study
    Ewout J Hoorn
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 26:1822-8. 2011
  9. pmc Mortality after hospitalization with mild, moderate, and severe hyponatremia
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 122:857-65. 2009
  10. pmc Prognostic importance of hyponatremia in patients with acute pulmonary embolism
    Nathalie Scherz
    Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
    Am J Respir Crit Care Med 182:1178-83. 2010

Detail Information

Publications346 found, 100 shown here

  1. ncbi Hyponatremia treatment guidelines 2007: expert panel recommendations
    Joseph G Verbalis
    Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia 20007, USA
    Am J Med 120:S1-21. 2007
    Although hyponatremia is a common, usually mild, and relatively asymptomatic disorder of electrolytes, acute severe hyponatremia can cause substantial morbidity and mortality, particularly in patients with concomitant disease...
  2. ncbi A case report of Sheehan's syndrome with acute onset, hyponatremia and severe anemia
    Salvatore Anfuso
    Department of Gynecology, Obstretrics and Neonatology, University of Parma, University Hospital of Parma, Italy
    Acta Biomed 80:73-6. 2009
    ..We report the case of a woman with an early diagnosis of early-onset Sheehan's syndrome associated with severe hyponatremia following dystocic childbirth complicated by postpartum hemorrhage.
  3. ncbi Hyponatremia and mortality among patients on the liver-transplant waiting list
    W Ray Kim
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 359:1018-26. 2008
    ..Under the current liver-transplantation policy, donor organs are offered to patients with the highest risk of death...
  4. pmc Mortality and serum sodium: do patients die from or with hyponatremia?
    Arun Chawla
    Division of Nephrology and Hypertension, Hofstra North Shore LIJ School of Medicine, Great Neck, New York, USA
    Clin J Am Soc Nephrol 6:960-5. 2011
    Severe hyponatremia (<120 mEq/L) in hospitalized patients has a high mortality rate. We hypothesized that underlying diseases causing hyponatremia attribute to mortality rather than hyponatremia itself.
  5. pmc Hyponatremia, hypernatremia, and mortality in patients with chronic kidney disease with and without congestive heart failure
    Csaba P Kovesdy
    Division of Nephrology, Salem Veterans Affairs Medical Center, 1970 Roanoke Blvd, Salem, VA 24153, USA
    Circulation 125:677-84. 2012
    b>Hyponatremia is common in patients with conditions such as congestive heart failure and is associated with increased mortality in hospitalized patients...
  6. ncbi Impact of hospital-associated hyponatremia on selected outcomes
    Ron Wald
    St Michael s Hospital and University of Toronto, and Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Arch Intern Med 170:294-302. 2010
    b>Hyponatremia is the most common electrolyte disorder encountered in hospitalized patients.
  7. pmc Three independent biological mechanisms cause exercise-associated hyponatremia: evidence from 2,135 weighed competitive athletic performances
    T D Noakes
    University of Cape Town Medical Research Council Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town Sports Science Institute of South Africa, Newlands, 7700, South Africa
    Proc Natl Acad Sci U S A 102:18550-5. 2005
    To evaluate the role of fluid and Na+ balance in the development of exercise-associated hyponatremia (EAH), changes in serum Na+ concentrations ([Na+]) and in body weight were analyzed in 2,135 athletes in endurance events...
  8. ncbi Mild hyponatremia as a risk factor for fractures: the Rotterdam Study
    Ewout J Hoorn
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 26:1822-8. 2011
    Recent studies suggest that mild hyponatremia is associated with fractures, but prospective studies are lacking. We studied whether hyponatremia is associated with fractures, falls, and/or bone mineral density (BMD)...
  9. pmc Mortality after hospitalization with mild, moderate, and severe hyponatremia
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 122:857-65. 2009
    b>Hyponatremia is the most common electrolyte abnormality in hospitalized individuals.
  10. pmc Prognostic importance of hyponatremia in patients with acute pulmonary embolism
    Nathalie Scherz
    Division of General Internal Medicine, University of Lausanne, Lausanne, Switzerland
    Am J Respir Crit Care Med 182:1178-83. 2010
    Although associated with adverse outcomes in other cardiopulmonary conditions, the prognostic value of hyponatremia, a marker of neurohormonal activation, in patients with acute pulmonary embolism (PE) is unknown.
  11. ncbi Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
    Douglas M Heuman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Hepatology 40:802-10. 2004
    ..Risk varied continuously with worsening hyponatremia. Modifying MELD, by including points for persistent ascites and low serum sodium, improved prediction of early ..
  12. ncbi Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia
    Robert W Schrier
    University of Colorado, Denver, USA
    N Engl J Med 355:2099-112. 2006
    b>Hyponatremia (serum sodium concentration, <135 mmol per liter) is a predictor of death among patients with chronic heart failure and cirrhosis...
  13. ncbi Hyponatremia in community-acquired pneumonia
    Vinay Nair
    Division of Nephrology, Winthrop University Hospital, Mineola, NY, USA
    Am J Nephrol 27:184-90. 2007
    ..The purpose of this study was to describe the incidence of hyponatremia in CAP and to analyze risk factors for its occurrence.
  14. ncbi Hyponatremia and inflammation: the emerging role of interleukin-6 in osmoregulation
    Reinout M Swart
    Department of Internal Medicine Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nephron Physiol 118:45-51. 2011
    Although hyponatremia is a recognized complication of several inflammatory diseases, its pathophysiology in this setting has remained elusive until recently...
  15. ncbi Hepatic venous pressure gradient can predict the development of hepatocellular carcinoma and hyponatremia in decompensated alcoholic cirrhosis
    Moon Young Kim
    Departments of Internal Medicine and Institute of Lifelong Health, Yonsei University Wonju College of Medicine, 162 Ilsan dong, Wonju, South Korea
    Eur J Gastroenterol Hepatol 21:1241-6. 2009
    ..We aimed to determine the relationship between hepatic venous pressure gradient (HVPG) and the development of HCC or low SNa in decompensated alcoholic cirrhosis patients...
  16. ncbi Incidence and prognosis of dysnatremias present on ICU admission
    Georg Christian Funk
    Department of Respiratory and Critical Care Medicine, Otto Wagner Spital, Vienna, Austria
    Intensive Care Med 36:304-11. 2010
    ..We hypothesized that dysnatremias at the time of ICU admission are independent risk factors for increased mortality in critically ill patients...
  17. ncbi Electrolyte disorders in community subjects: prevalence and risk factors
    George Liamis
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Med 126:256-63. 2013
    ..The aim of this study was to determine the prevalence and risk factors of common electrolyte disorders in older subjects recruited from the general population...
  18. ncbi Association of hyponatremia in acute stroke stage with three-year mortality in patients with first-ever ischemic stroke
    Wen Yi Huang
    Department of Neurology, Chang Gung Memorial Hospital, Keelung Branch, Taipei, Taiwan, ROC
    Cerebrovasc Dis 34:55-62. 2012
    b>Hyponatremia is the most common electrolyte disorder in hospitalized patients, and is frequently a marker of a significant underlying disease...
  19. ncbi Hyponatremia in hospitalized patients with the acquired immunodeficiency syndrome (AIDS) and the AIDS-related complex
    W W Tang
    Division of Nephrology, University of Southern California, Los Angeles
    Am J Med 94:169-74. 1993
    STUDY OBJECTIVE: To determine the frequency, etiology, and clinical association of hyponatremia in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC)...
  20. ncbi Incidence and prevalence of hyponatremia
    Ashish Upadhyay
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Med 119:S30-5. 2006
    b>Hyponatremia is the most common electrolyte abnormality encountered in clinical practice...
  21. ncbi Cerebral salt wasting syndrome following neurosurgical intervention in tuberculous meningitis
    L Nagotkar
    Pediatric Intensive Care Unit, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai 400 022, India
    Indian Pediatr 45:598-601. 2008
    ..The first patient was managed with rigorous salt and water replacement whereas the second patient required the addition of fludrocortisone for control of salt-wasting...
  22. ncbi Serum sodium predicts prognosis in critically ill cirrhotic patients
    Chang Chyi Jenq
    Division of Critical Care Nephrology, Department of Nephrology, Kidney Institute, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    J Clin Gastroenterol 44:220-6. 2010
    End-stage liver disease is often complicated by hyponatremia. Cirrhotic patients with hyponatremia admitted to intensive care units (ICUs) have high mortality rates...
  23. ncbi Exercise-associated hyponatremia
    Mitchell H Rosner
    Division of Nephrology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Clin J Am Soc Nephrol 2:151-61. 2007
    Exercise-associated hyponatremia has been described after sustained physical exertion during marathons, triathlons, and other endurance athletic events...
  24. ncbi Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults
    Susan Jacob
    Department of Pharmacy Services, Loma Linda Veterans Affairs Healthcare System, Loma Linda, CA, USA
    Ann Pharmacother 40:1618-22. 2006
    To review the incidence, risk factors, mechanism, times of onset and resolution, and treatment of hyponatremia associated with selective serotonin-reuptake inhibitors (SSRIs).
  25. pmc A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia
    Wei Tian
    Department of Medicine, Divisions of Nephrology and Hypertension, and Endocrinology and Metabolism, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 106:14034-9. 2009
    ..We show that this polymorphism is significantly associated with serum sodium concentration and with hyponatremia (serum sodium concentration < or =135 mEq/L) in 2 non-Hispanic Caucasian male populations; in addition, mean ..
  26. ncbi Hyponatremia and long-term mortality in survivors of acute ST-elevation myocardial infarction
    Alexander Goldberg
    Department of Cardiology, Rambam Medical Center and Rappaport Medical School, Haifa, Israel
    Arch Intern Med 166:781-6. 2006
    b>Hyponatremia, a marker of neurohormonal activation, is a common electrolyte disorder among patients with acute ST-elevation myocardial infarction...
  27. ncbi Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry
    Mihai Gheorghiade
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Galter 10 240, 201 E Huron Street, Chicago, IL 60611, USA
    Eur Heart J 28:980-8. 2007
    ..The predictive value of hyponatraemia has not been evaluated in unselected patients hospitalized with heart failure...
  28. ncbi Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE Trial
    Mihai Gheorghiade
    Division of Cardiology, Northwestern University, Feinberg School of Medicine, 201 E Huron Street, Chicago, IL 60611, USA
    Arch Intern Med 167:1998-2005. 2007
    Mild hyponatremia is relatively common in patients hospitalized with heart failure (HF)...
  29. ncbi Evidence-based incorporation of serum sodium concentration into MELD
    Scott W Biggins
    University of California San Francisco, San Francisco, California, USA
    Gastroenterology 130:1652-60. 2006
    ..Serum sodium (Na) concentrations have been suggested as a useful predictor of mortality in patients with end-stage liver disease awaiting liver transplantation...
  30. pmc Hyponatremia independent of osteoporosis is associated with fracture occurrence
    Sinead Kinsella
    Department of Nephrology, Cork University Hospital, Cork, Ireland
    Clin J Am Soc Nephrol 5:275-80. 2010
    Mild hyponatremia has traditionally been considered benign, but it may be associated with gait and attention deficits and an increased risk of falls that may result in fracture...
  31. ncbi Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia
    Mahmood Amiry-Moghaddam
    Centre for Molecular Biology and Neuroscience, and Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    FASEB J 18:542-4. 2004
    The formation of brain edema, commonly occurring as a potentially lethal complication of acute hyponatremia, is delayed following knockout of the water channel aquaporin-4 (AQP4)...
  32. ncbi Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone
    Andres E Ruf
    Liver Unit, Fundacion Favaloro, Buenos Aires, Argentina
    Liver Transpl 11:336-43. 2005
    In this study, we investigated the prognostic value of serum sodium and hyponatremia (< or =130 mEq/L) in 262 cirrhotic patients consecutively listed, 19 of which died (7%), 175 survived (67%), and 68 underwent liver transplantation (..
  33. ncbi Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management
    Pere Gines
    Liver Unit, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas IDIBAPS, Barcelona, Catalunya, Spain
    Hepatology 48:1002-10. 2008
    b>Hyponatremia is a frequent complication of advanced cirrhosis related to an impairment in the renal capacity to eliminate solute-free water that causes a retention of water that is disproportionate to the retention of sodium, thus causing ..
  34. ncbi Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia
    Juan Carlos Ayus
    Renal Consultants of Houston, 2412 Westgate Street, Houston, TX 77019, USA
    Am J Physiol Renal Physiol 295:F619-24. 2008
    b>Hyponatremia is the most common electrolyte abnormality in hospitalized patients. When symptomatic (hyponatremic encephalopathy), the overall morbidity is 34%...
  35. ncbi The correlation of hip fracture and hyponatremia in the elderly
    Ramin Tolouian
    Division of Nephrology, Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    J Nephrol 25:789-93. 2012
    Increasing age is considered one of the risk factors for hyponatremia. The concept of asymptomatic hyponatremia is not correct anymore as these patients have a greater risk for falls, bone fractures and attention impairment...
  36. ncbi Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia
    Nina S Stachenfeld
    The John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Appl Physiol (1985) 107:864-72. 2009
    We hypothesized that exercise-associated hyponatremia (EAH) is a function of excess sodium loss combined with high water intake in women at risk for dysnatremias during endurance exercise...
  37. ncbi Cerebral salt wasting syndrome: review
    M Cerda-Esteve
    Endocrinology Department, Hospital Universitari del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur J Intern Med 19:249-54. 2008
    b>Hyponatremia is the most frequent electrolyte disorder in critically neurological patients...
  38. ncbi Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations
    Joseph G Verbalis
    Georgetown University Medical Center, Washington, DC Electronic address
    Am J Med 126:S1-42. 2013
    b>Hyponatremia is a serious, but often overlooked, electrolyte imbalance that has been independently associated with a wide range of deleterious changes involving many different body systems...
  39. ncbi The syndrome of inappropriate antidiuresis: pathophysiology, clinical management and new therapeutic options
    Pasquale Esposito
    Department of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Italy
    Nephron Clin Pract 119:c62-73; discussion c73. 2011
    b>Hyponatremia is a marker of different underlying diseases and it can be a cause of morbidity itself; this implies the importance of a correct approach to the problem...
  40. pmc Hyponatremia, mineral metabolism, and mortality in incident maintenance hemodialysis patients: a cohort study
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, MA Scholars in Clinical Science Program, Harvard Medical School, Boston, MA Electronic address
    Am J Kidney Dis 62:755-62. 2013
    b>Hyponatremia is associated with increased mortality in chronic diseases. Recent animal studies also implicate hyponatremia in bone abnormalities...
  41. ncbi Burden of sodium abnormalities in patients hospitalized for heart failure
    Andrew F Shorr
    Washington Hospital Center, Washington, DC, USA
    Congest Heart Fail 17:1-7. 2011
    b>Hyponatremia presumably is associated with adverse clinical outcomes in patients with congestive heart failure (CHF), but risk thresholds and economic burden are less studied...
  42. ncbi Hyponatremia in hospitalized cancer patients and its impact on clinical outcomes
    Simit M Doshi
    Division of Internal Medicine, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Kidney Dis 59:222-8. 2012
    b>Hyponatremia is the most common electrolyte abnormality in clinical practice, yet little is known about its frequency in patients with cancer or its impact on their clinical outcomes.
  43. pmc Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats
    Julia Barsony
    Division of Endocrinology and Metabolism, Georgetown University, Washington, DC 20007, USA
    Age (Dordr) 35:271-88. 2013
    The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is frequently responsible for chronic hyponatremia in the elderly due to age-related disruption of the inhibitory component of brain osmoregulatory mechanisms...
  44. ncbi Hyponatremia, hypochloremia, and hypoalbuminemia predict an increased risk of mortality during the first year of antiretroviral therapy among HIV-infected Zambian and Kenyan women
    Christine N Dao
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    AIDS Res Hum Retroviruses 27:1149-55. 2011
    ..A body mass index <18 kg/m(2) [adjusted hazard ratio (aHR) 5.3, 95% confidence interval (CI) 2.6-10.6] and hyponatremia with hypochloremia (aHR 4.5, 95% CI 2.2-9...
  45. ncbi Hyponatremia in patients with acquired immune deficiency syndrome
    A J Cusano
    Department of Medicine, Long Island Jewish Medical Center, New Hyde Park 11042
    J Acquir Immune Defic Syndr 3:949-53. 1990
    ..AIDS) or AIDS-related complex (ARC) to determine the incidence, pathogenesis, and clinical significance of hyponatremia, defined as serum sodium levels less than or equal to 130 mmol/L on more than one occasion. Thirty (31...
  46. ncbi Hyponatremia and mortality: moving beyond associations
    Ewout J Hoorn
    Department of Internal Medicine Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Kidney Dis 62:139-49. 2013
    Acute hyponatremia can cause death if cerebral edema is not treated promptly. Conversely, if chronic hyponatremia is corrected too rapidly, osmotic demyelination may ensue, which also potentially is lethal...
  47. ncbi Dilutional hyponatremia in patients with cirrhosis and ascites
    Almudena Porcel
    Servicio de Aparato Digestivo, Hospital Universitario Puerta del Mar, c Ana de Viya 21, 11009, Cadiz, Spain
    Arch Intern Med 162:323-8. 2002
    To analyze the predisposing factors, modifications of vasoactive systems, and prognosis of patients with cirrhosis and hyponatremia.
  48. ncbi Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
    A Peri
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Viale Pieraccini 6, Florence, Italy
    J Endocrinol Invest 33:671-82. 2010
    ..referred to as the "syndrome of inappropriate antidiuresis", is an often underdiagnosed cause of hypotonic hyponatremia, resulting for instance from ectopic release of ADH in lung cancer or as a side-effect of various drugs...
  49. ncbi Cerebral salt wasting: pathophysiology, diagnosis, and treatment
    Alan H Yee
    Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Neurosurg Clin N Am 21:339-52. 2010
    Cerebral salt wasting (CSW) is a syndrome of hypovolemic hyponatremia caused by natriuresis and diuresis...
  50. ncbi Hyponatremia in patients undergoing CAPD: role of water gain and/or malnutrition
    G Zevallos
    Renal Division, Toronto Western Hospital, University of Toronto, Ontario, Canada
    Perit Dial Int 21:72-6. 2001
    BACKGROUND: Hyponatremia has a number of different causes; some may have serious untoward implications for patients undergoing chronic ambulatory peritoneal dialysis (CAPD)...
  51. ncbi Preoperative hyponatremia and perioperative complications
    Alexander A Leung
    Division of General Medicine and Primary Care, Brigham and Women s Hospital, Boston, MA 02120, USA
    Arch Intern Med 172:1474-81. 2012
    Although hyponatremia has been linked to increased morbidity and mortality in a variety of medical conditions, its association with perioperative outcomes remains uncertain.
  52. ncbi Natriuresis and "dilutional" hyponatremia after infusion of glycine 1.5%
    R G Hahn
    Department of Anesthesia, Soder Hospital, Stockholm, Sweden
    J Clin Anesth 13:167-74. 2001
    To challenge the view that the hyponatremia resulting from absorption of glycine 1...
  53. ncbi Reduced anterior hippocampal formation volume in hyponatremic schizophrenic patients
    M B Goldman
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Hippocampus 17:554-62. 2007
    ..Several lines of evidence suggest anterior hippocampal pathology underlies the life-threatening hyponatremia seen in a subgroup of patients with schizophrenia; therefore our goal was to determine if this region was ..
  54. ncbi Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis
    Florence Wong
    Department of Medicine, University of Toronto, Canada
    J Hepatol 53:283-90. 2010
    ....
  55. ncbi Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, Mass, USA
    Am J Med 120:461.e11-7. 2007
    Exercise-associated hyponatremia (EAH), as defined by a blood sodium concentration [Na+] less than 135 mmol/L, may lead to hypotonic encephalopathy with fatal cerebral edema...
  56. ncbi Risk factors for symptomatic hyponatraemia: the role of pre-existing asymptomatic hyponatraemia
    M Bissram
    Department of Internal Medicine, Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia, USA
    Intern Med J 37:149-55. 2007
    ..Methods: A retrospective analysis of the risks factors associated with the development of severe, symptomatic hyponatraemia requiring hospital admission over the past 3 years at our institution was carried out...
  57. ncbi Low prevalence of exercise-associated hyponatremia in male 100 km ultra-marathon runners in Switzerland
    Beat Knechtle
    Facharzt FMH fur Allgemeinmedizin, Gesundheitszentrum St Gallen, Vadianstrasse 26, 9001 St Gallen, Switzerland
    Eur J Appl Physiol 111:1007-16. 2011
    We investigated the prevalence of exercise-associated hyponatremia (EAH) in 145 male ultra-marathoners at the '100-km ultra-run' in Biel, Switzerland...
  58. ncbi Vaptans are not the mainstay of treatment in hyponatremia: perhaps not yet
    Peter A Gross
    Division of Nephrology, Department of Medicine III, Universitätsklinikum C G Carus, Fetscherstrasse 74, Dresden, Germany
    Kidney Int 80:594-600. 2011
    ..are now in the market for the treatment of euvolemic (Europe) or euvolemic and hypervolemic (United States) hyponatremia: conivaptan for intravenous use and tolvaptan for oral application...
  59. ncbi Hyponatremia in neurosurgical patients: clinical guidelines development
    Maryam Rahman
    Department of Neurosurgery, University of Florida, Gainesville, Florida 32610 0265, USA
    Neurosurgery 65:925-35; discussion 935-6. 2009
    Neurosurgical patients have a high risk of hyponatremia and associated complications...
  60. ncbi Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration
    Monica Guevara
    Liver Unit Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    Liver Int 30:1137-42. 2010
    ..In conclusion, in patients with refractory ascites, the occurrence of HE is related to the impairment of liver and renal function and presence of hyponatraemia...
  61. ncbi Hyponatremia and hypernatremia: disorders of water balance
    V Agrawal
    Department of Internal Medicine, William Beaumont Hospital, Royal Oak, MI, USA
    J Assoc Physicians India 56:956-64. 2008
    ..Abnormalities in water balance are manifested as sodium disturbances--hyponatremia and hypernatremia...
  62. ncbi Management of hyponatremia: providing treatment and avoiding harm
    Chirag Vaidya
    Tufts University School of Medicine, Renal Division, Baystate Medical Center, MA, USA
    Cleve Clin J Med 77:715-26. 2010
    b>Hyponatremia, in its most severe form, requires urgent infusion of hypertonic saline to correct cerebral edema. However, overly rapid correction of chronic hyponatremia can cause osmotic demyelination syndrome...
  63. ncbi Effect of hyponatraemia on outcomes following orthotopic liver transplantation
    William A Hackworth
    Liver Transplant Program, Hume Lee Transplant Center, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Liver Int 29:1071-7. 2009
    ..Hyponatraemia increases risk of adverse outcomes following orthotopic liver transplantation (OLT), but it is unclear whether improvement of pretransplant hyponatraemia ameliorates post-transplant complications...
  64. ncbi Hyponatremia in ultradistance triathletes
    D B Speedy
    SportsMed, Christchurch, New Zealand
    Med Sci Sports Exerc 31:809-15. 1999
    b>Hyponatremia ([plasma sodium] <135 mmol x L(-1)) is a potentially serious complication of ultraendurance sports. However, the etiology of this condition is still uncertain...
  65. ncbi Hyponatremia a valuable predictor of early mortality in patients with cirrhosis listed for liver transplantation
    Maryam Moini
    Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
    Clin Transplant 25:638-45. 2011
    ..from September 1998 to June 2007 were followed for six months from the time of listing to evaluate the value of hyponatremia on mortality...
  66. ncbi Hyponatremia: diagnosis, complications, and management including V2 receptor antagonists
    Elwaleed A Elhassan
    Division of Renal Diseases and Hypertension, University of Colorado Denver, 12700 East 19th Avenue, Aurora, CO 80045, USA
    Curr Opin Nephrol Hypertens 20:161-8. 2011
    Recent studies have consistently demonstrated the common prevalence of hyponatremia in the hospital and intensive care settings, and how it correlates with untoward outcomes...
  67. ncbi Structural pathology underlying neuroendocrine dysfunction in schizophrenia
    Morris B Goldman
    Northwestern University, Department of Psychiatry, 446 East Ontario, Suite 7 100, Chicago, IL 60611, United States
    Behav Brain Res 218:106-13. 2011
    ..Polydipsic patients without hyponatremia (polydipsic normonatremic schizophrenics: PNS) exhibit similar, albeit less marked, changes in neuroendocrine ..
  68. ncbi Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits
    Benoit Renneboog
    The Research Unit for the Study of Hydromineral Metabolism, ULB, Erasme Hospital, ULB, Brussels, Belgium
    Am J Med 119:71.e1-8. 2006
    The study objective was to determine the eventual consequences (falls, unsteadiness, and cognitive impairment) of mild chronic hyponatremia, which is generally considered as asymptomatic.
  69. ncbi [The gynecological TURP syndrome. Severe hyponatremia and pulmonary edema during hysteroscopy]
    G Serocki
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitätsklinikum Schleswig Holstein UKSH, Campus Kiel, Schwanenweg 21, 24105 Kiel, Deutschland
    Anaesthesist 58:30-4. 2009
    Fluid overload and dilutional hyponatremia are rare but typical complications of endoscopic transurethral resection of the prostate gland (TURP syndrome)...
  70. ncbi Severe hyponatremia due to hypopituitarism with adrenal insufficiency: report on 28 cases
    Sven Diederich
    Division of Endocrinology and Diabetes, Klinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 3012200 Berlin, Germany
    Eur J Endocrinol 148:609-17. 2003
    Severe hyponatremia due to hypopituitarism and adrenal insufficiency can be life-threatening, and treatment with glucocorticoids is very effective once the diagnosis of the underlying disorder has been made...
  71. pmc Oral tolvaptan is safe and effective in chronic hyponatremia
    Tomas Berl
    University of Colorado Denver, Division of Renal Diseases and Hypertension, Aurora, CO 80045, USA
    J Am Soc Nephrol 21:705-12. 2010
    ..antagonists increase the serum sodium concentration in patients who have euvolemia and hypervolemia with hyponatremia in the short term (</=30 days), but their safety and efficacy with longer term administration is unknown...
  72. ncbi Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis
    Monica Guevara
    Liver Unit, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona, Spain
    Am J Gastroenterol 104:1382-9. 2009
    The aim of this study was to investigate whether hyponatremia is a risk factor of overt hepatic encephalopathy (HE) in cirrhosis.
  73. ncbi Mild hyponatremia and risk of fracture in the ambulatory elderly
    F Gankam Kengne
    Service de médecine interne générale, Hopital Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium
    QJM 101:583-8. 2008
    Mild hyponatremia is the commonest electrolyte imbalance in the older population and has been shown to be associated with gait and attention deficits resulting in higher frequency of falls...
  74. ncbi A randomized controlled trial of hydrocortisone against hyponatremia in patients with aneurysmal subarachnoid hemorrhage
    Yoichi Katayama
    Stroke 38:2373-5. 2007
    b>Hyponatremia is common after aneurysmal subarachnoid hemorrhage (SAH). It is caused by natriuresis, which induces osmotic diuresis and decreases blood volume, contributing to symptomatic cerebral vasospasm (SCV)...
  75. pmc Hyponatremia and hospital outcomes among patients with pneumonia: a retrospective cohort study
    Marya D Zilberberg
    Evi Med Research Group, LLC, Goshen, Massachusetts, USA
    BMC Pulm Med 8:16. 2008
    ..b>Hyponatremia, occurring in >1/4 of patients with CAP, is associated with greater disease severity and worsened outcomes.
  76. ncbi Characteristics and mortality of severe hyponatraemia--a hospital-based study
    Geoffrey Gill
    Department of Diabetes and Endocrinology, University HospitalAintree, Liverpool, UK
    Clin Endocrinol (Oxf) 65:246-9. 2006
    ..To determine the characteristics, causes and outcome of severe hyponatraemia (< 125 mmol/l) in hospitalized patients, and to identify mortality predictors...
  77. ncbi Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial
    Pere Gines
    Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
    Hepatology 48:204-13. 2008
    b>Hyponatremia in cirrhosis is associated with significant morbidity and mortality and complicates ascites management...
  78. ncbi Therapeutic potential of vasopressin receptor antagonists
    Farhan Ali
    Heart Failure Program, Wayne State University, Detroit, Michigan, USA
    Drugs 67:847-58. 2007
    ..Ongoing clinical trials should further define the scope of the potential therapeutic role of VRAs...
  79. ncbi Hyponatremia among runners in the Boston Marathon
    Christopher S D Almond
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    N Engl J Med 352:1550-6. 2005
    b>Hyponatremia has emerged as an important cause of race-related death and life-threatening illness among marathon runners...
  80. ncbi Copeptin in the differential diagnosis of hyponatremia
    Wiebke Fenske
    Endocrinology and Diabetes Unit, Department of Medicine I, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 94:123-9. 2009
    Treatment of patients with hyponatremia varies widely; thus, convenient diagnostic parameters are needed to guide the correct treatment strategy...
  81. pmc Hyponatremia in severe malaria: evidence for an appropriate anti-diuretic hormone response to hypovolemia
    Josh Hanson
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 80:141-5. 2009
    Although hyponatremia occurs in most patients with severe malaria, its pathogenesis, prognostic significance, and optimal management have not been established...
  82. ncbi Paroxetine-induced hyponatremia in older adults: a 12-week prospective study
    Tanya J Fabian
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arch Intern Med 164:327-32. 2004
    Older depressed patients are at high risk for development of hyponatremia after initiation of the selective serotonin reuptake inhibitor paroxetine, despite clinical monitoring and preventive management...
  83. ncbi Hyponatremia associated with large-bone fracture in elderly patients
    Harminder S Sandhu
    Division of Nephrology, Lenox Hill Hospital, New York, NY 10075, USA
    Int Urol Nephrol 41:733-7. 2009
    b>Hyponatremia has been shown to be associated with gait disturbances, decreased mentation, and falls...
  84. ncbi The management of ascites and hyponatremia in cirrhosis
    Pere Gines
    Liver Unit, Hospital Clinic and University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Ciber de Enfermedades Hepaticas y Digestivas, Barcelona, Spain
    Semin Liver Dis 28:43-58. 2008
    ..of cirrhosis and is associated with an increased risk for the development of infections, dilutional hyponatremia, renal failure, and mortality...
  85. ncbi Severe hyponatraemia in elderly hospitalized patients: prevalence, aetiology and outcome
    D S Shapiro
    Department of Geriatrics, Shaare Zedek Medical Center Jerusalem, Israel
    Intern Med J 40:574-80. 2010
    ..We studied the incidence, frequency of various aetiologies, outcome and the possible role of CSWS in severe hyponatraemia in elderly medical patients...
  86. ncbi Fludrocortisone therapy in cerebral salt wasting
    Craig E Taplin
    The Children s Hospital at Westmead, Institute of Endocrinology and Diabetes, Locked Bag 4001, Westmead 2145, New South Wales, Australia
    Pediatrics 118:e1904-8. 2006
    ..We report 4 patients with cerebral salt wasting, all of whom presented with hyponatremia in the presence of known intracerebral pathology...
  87. ncbi Can changes in body mass and total body water accurately predict hyponatremia after a 161-km running race?
    Daniel K Lebus
    Sports Medicine Program, University of California Davis Medical Center, Sacramento, California, USA
    Clin J Sport Med 20:193-9. 2010
    To relate changes in body mass, total body water (TBW), extracellular fluid (ECF), and serum sodium concentration ([Na]) from a 161-km ultramarathon to finish time and incidence of hyponatremia.
  88. ncbi The incidence, risk factors, and clinical manifestations of hyponatremia in marathon runners
    Tamara D Hew
    Clin J Sport Med 13:41-7. 2003
    To report on the incidence, identify the risk factors, and clarify the clinical manifestations of acute hyponatremia in marathon runners.
  89. ncbi Mild hyponatremia carries a poor prognosis in community subjects
    Ahmad Sajadieh
    Clinic of Cardiology, Copenhagen University Hospital, Amager, Denmark
    Am J Med 122:679-86. 2009
    b>Hyponatremia has been shown to predict adverse outcome in congestive heart failure and pneumonia among other common clinical entities, but its significance in the general population is elusive.
  90. ncbi Hyponatremia resulting from arginine vasopressin receptor 2 gene mutation
    David Francisco Bes
    Department of Pediatrics, Hospital Nacional de Pediatria Prof Dr Juan P Garrahan, and Departamento de Riñón Experimental, Instituto de Investigaciones Médicas Dr Alfredo Lanari, Universidad de Buenos Aires, 1245, Argentina
    Pediatr Nephrol 22:463-6. 2007
    Chronic hyponatremia, unless associated with extracellular fluid volume expansion, is an infrequent electrolyte imbalance in pediatrics...
  91. pmc Hypotonic versus isotonic saline in hospitalised children: a systematic review
    K Choong
    Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada
    Arch Dis Child 91:828-35. 2006
    ..v.) maintenance fluids are the solutions of choice in paediatric patients have not been rigorously tested in clinical trials, and may not be appropriate for all children...
  92. ncbi Incidence of postoperative hyponatremia and complications in critically-ill children treated with hypotonic and normotonic solutions
    Alicia K Au
    Department of Pediatrics, Children s National Medical Center, Washington, DC, USA
    J Pediatr 152:33-8. 2008
    To determine the incidence and clinical consequences of postoperative hyponatremia in children.
  93. ncbi The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study
    P Alvarez Montañana
    Pediatric Intensive Care Unit, Hospital La Fe, Valencia, Spain
    Pediatr Crit Care Med 9:589-97. 2008
    Hypotonic fluids are widely used in pediatrics. Several articles have reported the risk of iatrogenic hyponatremia secondary to this practice...
  94. ncbi Randomised controlled trial of intravenous maintenance fluids
    Michael Yung
    Paediatric Intensive Care Unit, Women s and Children s Hospital, South Australia, Australia
    J Paediatr Child Health 45:9-14. 2009
    ..However, this may cause hyponatraemia in sick and post-operative children. We studied the effect of two types of intravenous maintenance fluid and two administration rates on plasma sodium concentration in intensive care patients...
  95. ncbi A review of drug-induced hyponatremia
    George Liamis
    Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
    Am J Kidney Dis 52:144-53. 2008
    b>Hyponatremia (defined as a serum sodium level < 134 mmol/L) is the most common electrolyte abnormality in hospitalized patients...
  96. ncbi Risk factors for thiazide-induced hyponatraemia
    K M Chow
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    QJM 96:911-7. 2003
    ..Thiazide-induced hyponatraemia is common and potentially life threatening. In the absence of well-defined risk factors for this complication, guidelines for prescribing cannot be established...
  97. pmc Isotonic is better than hypotonic saline for intravenous rehydration of children with gastroenteritis: a prospective randomised study
    K A Neville
    Department of Endocrinology, Sydney Children s Hospital, Sydney, Australia
    Arch Dis Child 91:226-32. 2006
    ..To determine whether the risk of hyponatraemia in children with gastroenteritis receiving intravenous (IV) fluids is decreased by the use of 0.9% saline...
  98. ncbi An integrative physiological approach to polyuria and hyponatraemia: a 'double-take' on the diagnosis and therapy in a patient with schizophrenia
    Y Edoute
    Department of Internal Medicine C, Rambam Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    QJM 96:531-40. 2003
    ..Applying this simple approach, a more comprehensive and accurate differential diagnosis, and a plan for therapy to avoid serious complications was compiled...
  99. ncbi The silent epidemic of thiazide-induced hyponatremia
    Samuel J Mann
    Division of Nephrology and Hypertension, Department of Medicine, New York Presbyterian Hospital Weill Cornell Medical Center, 525 East 68th Street, L 1, New York, NY 10021, USA
    J Clin Hypertens (Greenwich) 10:477-84. 2008
    b>Hyponatremia is a recognized complication of treatment with thiazide diuretics, particularly in patients older than 70 years...
  100. ncbi Beliefs about hydration and physiology drive drinking behaviours in runners
    James M Winger
    Department of Family Medicine, Loyola University Medical Center, Maywood, Illinois, USA
    Br J Sports Med 45:646-9. 2011
    ..Runners who drink more than to their thirst do so for a reason, and understanding and curtailing this behaviour will probably decrease the incidence of this highly preventable condition...
  101. ncbi Prevalence of exercise-associated hyponatremia in male ultraendurance athletes
    Beat Knechtle
    Gesundheitszentrum St Gallen, St Gallen, Switzerland Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland
    Clin J Sport Med 21:226-32. 2011
    The prevalence of exercise-associated hyponatremia (EAH) has mainly been investigated in marathoners and Ironman triathletes...

Research Grants63

  1. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..Our studies in the ovine model indicate that maternal hydration and DDAVP induces maternal and fetal plasma hyponatremia, marked increases in fetal urine flow, reduced fetal swallowing and expansion of AF volume...
  2. Regulation of neural cell volume by thrombin receptors
    Tooba Cheema; Fiscal Year: 2006
    ..Neural cell swelling often results from a lowering of plasma osmolarity, a clinical condition known as hyponatremia. A homeostatic mechanism known as regulatory volume decrease (RVD) is crucial in the central nervous system to ..
  3. Role of TRP Channels on Collecting Duct Calcium Dynamics
    ROGER O NEIL; Fiscal Year: 2009
    ..g., hyponatremia, diabetes insipidus, diabetes mellitus, diuretic administration), which will contribute to hypocaliuric and/or ..
  4. Molecular and Cellular Regulation of Mammalian Renal Medulla Development
    Jing Yu; Fiscal Year: 2013
    ..Disorders in water and salt balance cause hyponatremia, hypernatremia and nephrogenic diabetes insipidus...
  5. Polymorphism affecting water balance
    David M Cohen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Disorders of water balance (i.e., hypernatremia and hyponatremia) are the most frequently encountered of the electrolyte problems;they are exceedingly common among the elderly, the acutely and ..
  6. Role of the CNS in Inappropriate Vasopressin Release Associated with Cirrhosis
    JOSEPH D WALCH; Fiscal Year: 2013
    ..This training program involves applying state of the art research techniques to study the pathophysiology of hyponatremia in an animal model of liver disease...
  7. Central Kappa Opioid Neural Regulation of Cardiovascular and Renal Function
    Helmut B Gottlieb; Fiscal Year: 2012
    ..Chronic activation of these systems can produce hyponatremia, pulmonary congestion, and eventual death...
  8. Neural Control of Vasopressin Release
    J Thomas Cunningham; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hyponatremia is the most common electrolyte disorder and in 2006 the cost of treating hyponatremia in the US was estimated to be $1.6-$3.6 billion per year...
  9. Cell Biology of Vasopressin-Induced Water Channels
    Dennis Brown; Fiscal Year: 2013
    ..therapeutic approaches for disorders of fluid balance including NDI, as well as congestive heart failure and hyponatremia. In Aim 1, we will explore the mechanism(s) underlying our recent discoveries that AQP2 itself is a catalyst ..
  10. The Impact of the MELD Score at the Time of Listing for Liver Transplantation
    Alyson N Fox; Fiscal Year: 2010
    ..list: etiology of liver disease or having had a complication of portal hypertension prior to listing (hyponatremia, refractory ascites, spontaneous bacterial peritonitis, variceal hemorrhage, or encephalopathy of sufficient ..
  11. Genetics of water balance
    David M Cohen; Fiscal Year: 2013
    ..water balance is detected clinically by an increase or decrease in the serum sodium concentration (hyper- and hyponatremia, respectively)...
  12. Zymogen activation in pancreatitis
    Fred S Gorelick; Fiscal Year: 2013
    ..also differs among intravenous solutions;administering fluids low in sodium can reduce its levels in the blood (hyponatremia)...
  13. Clinical Pharmacology of 3,4-Methylenedioxy Amphetamines
    John E Mendelson; Fiscal Year: 2010
    ..Experiment 4 will investigate the mechanisms undedying MDMA-induced hyponatremia, a significant complication of MDMA abuse seen in primarily female "rave" party participants...
  14. AQUAPORIN-2 EXCRETION IN DISORDERS OF WATER BALANCE
    Melissa Cadnapaphornchai; Fiscal Year: 2004
    ..and expression of AQP-2 in certain physiologic and pathologic states may contribute to such complications as hyponatremia, hypoosmolality, and edema...
  15. OPIOIDS AND CENTRAL NEURAL REGULATION OF RENAL FUNCTION
    DANIEL KAPUSTA; Fiscal Year: 2007
    ..of body fluid and electrolyte balance under states in which fluid overload and/or sodium deficiency may provoke hyponatremia/hypoosmolality...
  16. The Sulfur/Glutamate Circuitry in the Neuroimmune System
    Ruma Banerjee; Fiscal Year: 2009
    ..context of neuroprotection with biomedical relevance to a range of pathologies from Alzheimer's disease to hyponatremia. PUBLIC HEALTH RELEVANCE: In brain, sulfur metabolism modulates antioxidant capacity and cell volume regulation ..
  17. Regulation of Human Amino Acid Transport System A Gene
    Ohnn Nahm; Fiscal Year: 2003
    ..during pathologic changes in serum osmolality, which is essential for management of patients with hyper-or hyponatremia. During the entire funding period, he will be under the meticulous supervision of Dr. H...
  18. MECHANISM OF ABNORMAL WATER EXCRETION IN SCHIZOPHRENIA
    Morris Goldman; Fiscal Year: 1991
    ..The abnormalities were not severe enough to account for the episodes of more severe hyponatremia that accompany water intoxication...
  19. VASOPRESSIN & ALPHA-ADRENOCEPTORS--ELDERLY HYPERTENSION
    Haralambos Gavras; Fiscal Year: 1990
    ..effect of a vasopressin inhibitor with combined V1 and V2 action in elderly hypertensives with diuretic-induced hyponatremia. These studies should advance our understanding of the mechanisms participating in the maintenance of the non-..
  20. Genetic determinants of water balance in the elderly
    David Cohen; Fiscal Year: 2009
    ..hypo- and hypernatremia) are extremely common among the elderly, chronically ill, and hospitalized patients. Hyponatremia, particularly if severe, is associated with markedly increased mortality, even in the absence of evident ..
  21. RENAL WATER AND ION TRANSPORT: ROLE OF PROTEINS
    IRWIN SINGER; Fiscal Year: 1980
    ..g., tetracycline ADH-antagonists for hyponatremia).
  22. MULTIDISCIPLINARY NMR CENTER FOR BIOMEDICAL RESEARCH
    Chien Ho; Fiscal Year: 2002
    ..These seven project are as follows: (i) correction of hyponatremia and pathogenesis of osmotic induce demyelination: (ii) the stunned heart and cardiac surgery: protein kinase C; ..
  23. ION CHANNELS IN VOLUME REGULATION BY NEUROBLASTOMA CELLS
    Stanley Misler; Fiscal Year: 1992
    ..These results may help to elucidate the mechanism used by brain cells to limit swelling during hyponatremia, ischemia, insult by neurotoxic excitatory transmitters, and even cell growth.
  24. HYPONATREMIA-INDUCED OSTEOPOROSIS
    Joseph G Verbalis; Fiscal Year: 2010
    ..other potential causes of bone loss, clinical cases of unexplained osteoporosis in patients with chronic hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) prompted us to examine this as ..
  25. GEORGETOWN UNIVERSITY-MEDSTAR CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE
    Joseph Verbalis; Fiscal Year: 2006
    ..The planning process will be led by a committee of faculty members who are leaders in translational research and clinical research training at the member institutions. [unreadable] [unreadable] [unreadable]..
  26. BRAIN OXYTOCIN AND ETHANOL EFFECT ON INGESTIVE BEHAVIOR
    Joseph Verbalis; Fiscal Year: 2001
    ....
  27. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITY
    Joseph Verbalis; Fiscal Year: 2002
    b>Hyponatremia is the most common electrolyte disorder of hospitalized patients in the United States and is a significant cause of morbidity and mortality...
  28. Advances in Renal Research: Human Diseases of Protein Processing
    David Ellison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Molecular Physiology of Renal K-Cl Cotransporters
    David Mount; Fiscal Year: 2007
    ..abstract_text> ..
  30. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
    ..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
  31. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
  32. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2008
    ..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
  33. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
  34. OPIOIDS AND CENTRAL NEURAL REGULATION OF RENAL FUNCTION
    DANIEL KAPUSTA; Fiscal Year: 2003
    ..In summary, an RCDA will greatly enhance my research productivity and scientific career. ..
  35. CHRONIC NEUROPATHIC PAIN MECHANISMS AND MANAGEMENT
    Michael Rowbotham; Fiscal Year: 2004
    ....
  36. TNF-ALPHA REGULATION OF AT1 RECEPTOR & POST-MI FIBROSIS
    Barry Greenberg; Fiscal Year: 2003
    ..This information will provide important insights into the pathogenesis of post-MI fibrosis. ..
  37. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  38. Biochemical markers of bone turnover in metastatic prostate cancer
    Primo N Lara; Fiscal Year: 2010
    ....
  39. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  40. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  41. Role of Parabrachial 5-HT in Thirst and Salt Appetite
    Alan Johnson; Fiscal Year: 2005
    ..g., hypertension; congestive heart failure; renal disease). ..
  42. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2006
    ..Accordingly, knowledge of the signal transduction pathways that regulate VSOAC is an essential prerequisite for the rational design of therapeutic agents. ..
  43. Apoptosis in myelofibrosis with myeloid metaplasia
    Ruben Mesa; Fiscal Year: 2006
    ..abstract_text> ..
  44. PEDIATRIC NEPHROLOGY TRAINING
    Michel Baum; Fiscal Year: 2005
    ..Fellows also attend seminars in basic science departments. The research mentor, as well as the program director, closely supervise trainees to ensure that the goals of the training program are achieved. ..
  45. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2007
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  46. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
  47. Reducing Adverse Self-Medication Behaviors in Older Adults with Hypertension
    Patricia Neafsey; Fiscal Year: 2007
    ..Healthcare utilization will be compared between the 2 groups after 52 weeks and a cost-benefit analysis conducted. [unreadable] [unreadable] [unreadable]..
  48. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  49. PTSD and Drug Dependence: Neuroimaging of Reward Circui*
    Igor Elman; Fiscal Year: 2007
    ..Number of publications and manuscdpts accepted for publication (not to exceed 10) Other items (list): Appendix I Color Plates of Figures in Preliminary Studies PHS 398 (Rev. 05/01) Page 3 Form Page 3 ..
  50. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  51. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
  52. NEURAL REGULATION OF VASOPRESSIN RELEASE
    J Thomas Cunningham; Fiscal Year: 2010
    ..The regulation of vasopressin release may be of particular importance in understanding dilutional hyponatremia, a common hydromineral imbalance that increases the morbidity and mortality of patients with congestive heart ..
  53. SUBSTANCE P, NO & MICROGLIA IN CNS INFLAMMATION
    Barnett Nathan; Fiscal Year: 2003
    ..SP and NO modulate their effects in CNS inflammation via these cells. Hypothesis 4: The ultimate site for the effects of SP and NO may be the mitochondrial respiratory chain enzymes of these phagocytic cells. ..
  54. NaCI Balance and Targeted Insulin Receptor Knockout Mice
    Carolyn Ecelbarger; Fiscal Year: 2004
    ..Overall, we believe these models will provide fresh molecular insight into a physiological phenomenon that has been known for decades, insulin induced hypertension, with clear clinical ramifications. ..
  55. Decision Making in End-Stage Heart Failure
    Paul Hauptman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  56. Angiogenesis in hyperoxic lung fibrosis
    Ivor Douglas; Fiscal Year: 2007
    ..Columbia University has an established record of successful mentorship and training for K08 Career awardees in their preparation for careers as independent. ..
  57. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
    ..These studies will not only examine the pathogenesis of this disorder, but will directly examine if indomethacin potentially represents a novel therapy for this disease. ..
  58. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  59. Genes Related to HCC Progression in LD and DD Transplant
    Robert A Fisher; Fiscal Year: 2010
    ..abstract_text> ..