hypernatremia

Summary

Summary: Excessive amount of sodium in the blood. (Dorland, 27th ed)

Top Publications

  1. ncbi Pediatric fluid and electrolyte balance: critical care case studies
    Kathryn E Roberts
    Pediatric Intensive Care Unit, The Children s Hospital of Philadelphia, 34th Street and Civic Center, Philadelphia, PA 19104, USA
    Crit Care Nurs Clin North Am 17:361-73, x. 2005
  2. ncbi Therapeutic approach in patients with dysnatraemias
    George Liamis
    FRSH, FASA, Department of Internal Medicine, University of Ioannina, 45110 Ioannina, Greece
    Nephrol Dial Transplant 21:1564-9. 2006
  3. ncbi Potassum and sodium homeostasis in the neonate
    Patricia L Nash
    SSM Cardinal Glennon Children s Medical Center, St Louis, Missouri, USA
    Neonatal Netw 26:125-8. 2007
  4. ncbi Age and gender as risk factors for hyponatremia and hypernatremia
    Robert C Hawkins
    Department of Pathology and Laboratory Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
    Clin Chim Acta 337:169-72. 2003
  5. doi Renal sympathoinhibition induced by hypernatremia: involvement of A1 noradrenergic neurons
    Gustavo Rodrigues Pedrino
    Department of Physiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
    Auton Neurosci 142:55-63. 2008
  6. ncbi Clinical presentation of hypernatremia in elderly patients: a case control study
    Philippe Chassagne
    Geriatrics Department, CHU Rouen, Rouen, France
    J Am Geriatr Soc 54:1225-30. 2006
  7. doi Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia
    Takeshi Y Hiyama
    Division of Molecular Neurobiology, The Graduate University for Advanced Studies, Okazaki, Aichi 444 8787, Japan
    Neuron 66:508-22. 2010
  8. doi Renal vasodilation induced by hypernatraemia: role of alpha-adrenoceptors in the median preoptic nucleus
    Gustavo R Pedrino
    Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Clin Exp Pharmacol Physiol 36:e83-9. 2009
  9. doi A clinical approach to the treatment of chronic hypernatremia
    Ahmed Al-Absi
    Nephrology Division, University of Wisconsin Madison, WI, USA
    Am J Kidney Dis 60:1032-8. 2012
  10. pmc A2 noradrenergic lesions prevent renal sympathoinhibition induced by hypernatremia in rats
    Gustavo Rodrigues Pedrino
    Department of Physiological Science, Universidade Federal de Goias, Goiania, Goias, Brazil
    PLoS ONE 7:e37587. 2012

Detail Information

Publications239 found, 100 shown here

  1. ncbi Pediatric fluid and electrolyte balance: critical care case studies
    Kathryn E Roberts
    Pediatric Intensive Care Unit, The Children s Hospital of Philadelphia, 34th Street and Civic Center, Philadelphia, PA 19104, USA
    Crit Care Nurs Clin North Am 17:361-73, x. 2005
    ..Imbalances in fluid homeostasis and imbalances in sodium, potassium, and calcium homeostasis are presented in a case study format...
  2. ncbi Therapeutic approach in patients with dysnatraemias
    George Liamis
    FRSH, FASA, Department of Internal Medicine, University of Ioannina, 45110 Ioannina, Greece
    Nephrol Dial Transplant 21:1564-9. 2006
    ..The aim of this study is to evaluate the utility or/and the accuracy of the Adrogue-Madias formula in managing patients with hyponatraemia and hypernatraemia...
  3. ncbi Potassum and sodium homeostasis in the neonate
    Patricia L Nash
    SSM Cardinal Glennon Children s Medical Center, St Louis, Missouri, USA
    Neonatal Netw 26:125-8. 2007
  4. ncbi Age and gender as risk factors for hyponatremia and hypernatremia
    Robert C Hawkins
    Department of Pathology and Laboratory Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
    Clin Chim Acta 337:169-72. 2003
    This study assesses gender and age as independent risk factors for hypo- and hypernatremia and describes the prevalence of hypo- and hypernatremia in different population groups.
  5. doi Renal sympathoinhibition induced by hypernatremia: involvement of A1 noradrenergic neurons
    Gustavo Rodrigues Pedrino
    Department of Physiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
    Auton Neurosci 142:55-63. 2008
    ..These results suggest that A1 noradrenergic neurons are involved in the sympathoinhibition and consequent renal vasodilatation to acute changes in the extracellular fluid compartment...
  6. ncbi Clinical presentation of hypernatremia in elderly patients: a case control study
    Philippe Chassagne
    Geriatrics Department, CHU Rouen, Rouen, France
    J Am Geriatr Soc 54:1225-30. 2006
    To assess early clinical signs and their prognostic value in elderly patients with hypernatremia.
  7. doi Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia
    Takeshi Y Hiyama
    Division of Molecular Neurobiology, The Graduate University for Advanced Studies, Okazaki, Aichi 444 8787, Japan
    Neuron 66:508-22. 2010
    ..Here we report a case with clinical features of essential hypernatremia without demonstrable hypothalamic structural lesions, who was diagnosed as a paraneoplastic neurologic ..
  8. doi Renal vasodilation induced by hypernatraemia: role of alpha-adrenoceptors in the median preoptic nucleus
    Gustavo R Pedrino
    Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Clin Exp Pharmacol Physiol 36:e83-9. 2009
    ..However nanoinjection of yohimbine 60 min after HS failed to reduce renal vasodilatation induced by hypernatremia. 5...
  9. doi A clinical approach to the treatment of chronic hypernatremia
    Ahmed Al-Absi
    Nephrology Division, University of Wisconsin Madison, WI, USA
    Am J Kidney Dis 60:1032-8. 2012
    b>Hypernatremia is a commonly encountered electrolyte disorder occurring in both the inpatient and outpatient settings...
  10. pmc A2 noradrenergic lesions prevent renal sympathoinhibition induced by hypernatremia in rats
    Gustavo Rodrigues Pedrino
    Department of Physiological Science, Universidade Federal de Goias, Goiania, Goias, Brazil
    PLoS ONE 7:e37587. 2012
    Renal vasodilation and sympathoinhibition are recognized responses induced by hypernatremia, but the central neural pathways underlying such responses are not yet entirely understood...
  11. doi Severe hypernatremia in an extremely low birth weight infant with subsequent normal neurological development
    Hemmen Sabir
    Neonatology and Pediatric Intensive Care Medicine, Department of General Pediatrics, Heinrich Heine University, Dusseldorf, Germany
    Neonatology 97:90-2. 2010
    Severe preterm hypernatremia is a life-threatening electrolyte disorder which mainly causes neurological complications such as brain edema, intracranial hemorrhages, hemorrhagic infarctions and thromboses...
  12. ncbi Idiopathic hypothalamic dysfunction with precocious puberty and adipsic hypernatremia first presenting in adolescence
    M S Cauble
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-3020, USA
    J Pediatr Endocrinol Metab 14:1163-7. 2001
    ..This syndrome is characterized by a disturbance of thirst regulation with hypernatremia, hyperosmolarity, and altered hypothalamic function...
  13. ncbi Adipsic hypernatremia with a reset osmostat
    Bhasker Bappal
    Department of Child Health Endocrine and Metabolic Unit, Royal Hospital, PO Box 1331, Seeb 111, Muscat, Sultanate of Oman
    Saudi Med J 27:727-9. 2006
  14. doi Hypernatremia and grade III/IV intraventricular hemorrhage among extremely low birth weight infants
    W H Lim
    Division of Neonatology, Chang Gung Children s Hospital, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    J Perinatol 31:193-8. 2011
    ..To identify the risk factors contributing to intraventricular hemorrhage (IVH) in extremely low birth weight infants during early postnatal life, after appropriate matching for gestational age (GA) and birth body weight (BBW)...
  15. pmc Hypernatremia in the aging: causes, manifestations, and outcome
    S I Borra
    Department of Medicine, Kingsbrook Jewish Medical Center, Brooklyn, New York, USA
    J Natl Med Assoc 87:220-4. 1995
    ..Records of all patients who were admitted or developed hypernatremia (Na+ > 150 mEq/L) were reviewed...
  16. doi Hypernatremia in critically ill patients
    Gregor Lindner
    Department of Emergency Medicine, Inselspital, University of Bern, 3010 Bern, Switzerland
    J Crit Care 28:216.e11-20. 2013
    b>Hypernatremia is common in intensive care units. It has detrimental effects on various physiologic functions and was shown to be an independent risk factor for increased mortality in critically ill patients...
  17. doi Donor hypernatremia influences outcomes following pediatric liver transplantation
    Neema Kaseje
    Department of Pediatric Surgery, University Children s Hospital Geneva, 6 Rue Willy Donze, Geneva, Switzerland
    Eur J Pediatr Surg 23:8-13. 2013
    ..rising demand for liver transplantations (LTs), and the shortage of organs, extended criteria including donor hypernatremia have been adopted to increase the donor pool...
  18. pmc Community-acquired hypernatremia in elderly and very elderly patients admitted to the hospital: clinical characteristics and outcomes
    Kenan Turgutalp
    Division of Nephrology, Department of Internal Medicine, School of Medicine, Mersin University, Mersin, Turkey
    Med Sci Monit 18:CR729-34. 2012
    The clinical features, outcome and cost burden of community-acquired hypernatremia (CAH) in elderly and very elderly patients are not well known...
  19. doi Breast-feeding-associated hypernatremia: retrospective analysis of 169 term newborns
    Sevim Unal
    Neonatal Intensive Care Unit, Turkey Ministry of Health Ankara Diskapi Children s and Research Hospital, Ankara, Turkey
    Pediatr Int 50:29-34. 2008
    ..The aim of the present paper was to define the incidence, complications, morbidity and mortality of hypernatremic dehydration due to inadequate breast-feeding in a neonatal intensive care unit...
  20. pmc A1 noradrenergic neurons lesions reduce natriuresis and hypertensive responses to hypernatremia in rats
    Elaine Fernanda da Silva
    Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goias, Goiania, Goias, Brazil
    PLoS ONE 8:e73187. 2013
    ..These results suggest that medullary noradrenergic A1 neurons are involved in the excitatory neural pathway that regulates hypertensive and natriuretic responses to acute changes in the composition of body fluid. ..
  21. doi Safety and efficacy of intravenous hypotonic 0.225% sodium chloride infusion for the treatment of hypernatremia in critically ill patients
    Roland N Dickerson
    Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Nutr Clin Pract 28:400-8. 2013
    The purpose of this study was to evaluate the safety and efficacy of central venous administration of a hypotonic 0.225% sodium chloride (one-quarter normal saline [¼ NS]) infusion for critically ill patients with hypernatremia.
  22. doi Significance of hypo- and hypernatremia in chronic kidney disease
    Csaba P Kovesdy
    Division of Nephrology, Salem Veterans Affairs Medical Center, Salem, VA, USA
    Nephrol Dial Transplant 27:891-8. 2012
    Both hypo- and hypernatremia are common conditions, especially in hospitalized patients and in patients with various comorbid conditions such as congestive heart failure or liver cirrhosis...
  23. doi Severe hypernatremia correction rate and mortality in hospitalized patients
    Hala M Alshayeb
    Division of Nephrology, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Am J Med Sci 341:356-60. 2011
    b>Hypernatremia is a common problem in hospitalized patients and is associated with high morbidity and mortality...
  24. pmc Hyponatremia, hypernatremia, and mortality in patients with chronic kidney disease with and without congestive heart failure
    Csaba P Kovesdy
    Division of Nephrology, Salem Veterans Affairs Medical Center, 1970 Roanoke Blvd, Salem, VA 24153, USA
    Circulation 125:677-84. 2012
    ..Congestive heart failure is common in patients with chronic kidney disease, but the association of serum sodium concentration with mortality in such patients is not well characterized...
  25. doi Predictors of death in under-five children with diarrhoea admitted to a critical care ward in an urban hospital in Bangladesh
    Mohammod J Chisti
    Clinical Sciences Division, International Centre for Diarrhoeal Disease Research ICDDR, B, Dhaka, Bangladesh
    Acta Paediatr 100:e275-9. 2011
    ..To evaluate the clinical and laboratory predictors of death in hospitalized under-five children with diarrhoea...
  26. doi Central pontine and extrapontine myelinolysis in a pediatric patient following rapid correction of hypernatremia
    S Mastrangelo
    Division of Pediatric Oncology, Catholic University, Rome, Italy
    Neuropediatrics 40:144-7. 2009
    ..He achieved an almost full neurological recovery and radiological improvement. The reported case demonstrates that central pontine and extrapontine myelinolysis can occur after excessively rapid correction of hypernatremia.
  27. ncbi The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure
    Nicholas Murphy
    Institute of Liver Studies, Kings College Hospital, London, United Kingdom
    Hepatology 39:464-70. 2004
    ..In the current prospective randomized controlled clinical trial, we examined the effect of induced hypernatremia on the incidence of intracranial hypertension (IH) in patients with ALF...
  28. doi Encephalopathies caused by electrolyte disorders
    Martin A Samuels
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Neurol 31:135-8. 2011
    ..Hyperosmolality is usually related to hypernatremia and/or hyperglycemia...
  29. ncbi Hyponatremia and hypernatremia: disorders of water balance
    V Agrawal
    Department of Internal Medicine, William Beaumont Hospital, Royal Oak, MI, USA
    J Assoc Physicians India 56:956-64. 2008
    ..Abnormalities in water balance are manifested as sodium disturbances--hyponatremia and hypernatremia. Hyponatremia ([Na+ < 136 meq/ l]) is a common abnormality in hospitalized patients and is associated with ..
  30. ncbi Hypernatraemia in critically ill patients: too little water and too much salt
    Ewout J Hoorn
    Erasmus Medical Center, Dialysis Unit, Room Bd 391, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Nephrol Dial Transplant 23:1562-8. 2008
    ..Our objective was to study the risk factors and mechanisms of hypernatraemia in critically ill patients, a common and potentially serious problem...
  31. ncbi Preventing neurological complications from dysnatremias in children
    Michael L Moritz
    Division of Nephrology, Department of Pediatrics, Children s Hospital of Pittsburgh, The University of Pittsburgh School of Medicine, PA 15213 2538, USA
    Pediatr Nephrol 20:1687-700. 2005
    ..Hospital-acquired hypernatremia occurs in patients who have restricted access to fluids in combination with ongoing free-water losses...
  32. ncbi The pattern of plasma sodium abnormalities in an acute elderly care ward: a cross-sectional study
    K A O'Connor
    South Munster Geriatric Training Scheme, Dept of Geriatric Medicine, Cork University Hospital, Wilton, Cork
    Ir J Med Sci 175:28-31. 2006
    ..The combination of ageing, illness, and medications can lead to hyponatraemia or hypernatraemia...
  33. ncbi Hypernatremia in the neurologic intensive care unit: how high is too high?
    Venkatesh Aiyagari
    Neurology Neurosurgery Intensive Care Unit, Departments of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO, USA
    J Crit Care 21:163-72. 2006
    b>Hypernatremia is associated with increased mortality in hospitalized patients and in medical/surgical intensive care units...
  34. ncbi Hyponatremia and hypernatremia. A systematic approach to causes and their correction
    P J Fall
    Medical College of Georgia School of Medicine, Section of Nephrology, Augusta 30912 3140, USA
    Postgrad Med 107:75-82; quiz 179. 2000
    ..Results of these findings are helpful in guiding therapy. Monitoring serum sodium concentration often to ensure adequate treatment and to avoid potential complications is required in management of both hyponatremia and hypernatremia.
  35. ncbi Antidiuretic hormone. Normal and disordered function
    G L Robertson
    Departments of Medicine and Neurology, Northwestern University Medical School, Chicago, Illinois, USA
    Endocrinol Metab Clin North Am 30:671-94, vii. 2001
    ..These plexuses drain into the systemic circulation by way of the cavernous sinus and superior vena cava...
  36. ncbi Disorders of water imbalance
    Michelle Lin
    San Francisco General Hospital Emergency Services, University of California San Francisco, 1001 Potrero Avenue, Suite 1E21, San Francisco, CA 94110, USA
    Emerg Med Clin North Am 23:749-70, ix. 2005
    Disorders of water imbalance manifest as hyponatremia and hypernatremia. To diagnose these disorders, emergency physicians must maintain a high index of suspicion, especially in the high-risk patient, because clinical presentations may ..
  37. ncbi Hypernatremia in the intensive care unit: an indicator of quality of care?
    K H Polderman
    Medical Intensive Care Unit, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Crit Care Med 27:1105-8. 1999
    To assess the frequency of hypernatremia in patients who were admitted to an intensive care unit (ICU) and to determine the correlation of hypernatremia with the clinical outcomes, durations of the patients' stays in the ICU, and other ..
  38. ncbi Hypernatremia in the critically ill is an independent risk factor for mortality
    Gregor Lindner
    Intensive Care Unit 13H1, Medical University of Vienna, Sozialmedizinisches Zentrum Baumgartner Höhe Otto Wagner Spital, Vienna, Austria
    Am J Kidney Dis 50:952-7. 2007
    b>Hypernatremia is common in the intensive care unit (ICU). We assessed the prevalence of hypernatremia and its impact on mortality and ICU length of stay (LOS).
  39. doi Acquired hypernatraemia is an independent predictor of mortality in critically ill patients
    S D O'Donoghue
    Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Anaesthesia 64:514-20. 2009
    ..71) and duration of hypernatraemia (p = 1.0). Hypernatraemia avoidance is justified, but determinants of hypernatraemia and benefits of targeted treatment strategies require further elucidation...
  40. ncbi [Severe hypernatremia: survival without neurologic sequelae]
    R R Borrego Domínguez
    Sección de Cuidados Intensivos Pediátricos Hospital General Universitario Gregorio Marañón Madrid España
    An Pediatr (Barc) 58:376-80. 2003
    b>Hypernatremia is an electrolyte disturbance most frequently caused by excess water loss and less frequently by increased sodium intake...
  41. ncbi Weight loss and hypernatremia in breast-fed babies: frequency in neonates with non-hemolytic jaundice
    Aylin Tarcan
    Department of Pediatrics, Faculty of Medicine, Baskent University, Ankara, Turkey
    J Paediatr Child Health 41:484-7. 2005
    The aim of this study was to determine what proportion of newborns admitted with idiopathic non-hemolytic hyperbilirubinemia exhibit severe weight loss and hypernatremia.
  42. pmc The relation between the incidence of hypernatremia and mortality in patients with severe traumatic brain injury
    Umberto Maggiore
    Dipartimento di Clinica Medica, Nefrologia and Scienze della Prevenzione, Universita degli Studi di Parma, Via Gramsci 14, 43100 Parma, Italy
    Crit Care 13:R110. 2009
    The study was aimed at verifying whether the occurrence of hypernatremia during the intensive care unit (ICU) stay increases the risk of death in patients with severe traumatic brain injury (TBI)...
  43. ncbi Prenatal programming of hypernatremia and hypertension in neonatal lambs
    Michael G Ross
    Department of Obstetrics and Gynecology, University of California, Los Angeles, Harbor UCLA Medical Center, 1000 W Carson St, Box 3, Torrance, CA 90509, USA
    Am J Physiol Regul Integr Comp Physiol 288:R97-103. 2005
    ..Pre-Dehy lambs were exposed to in utero hypernatremia (8- to 10-meq increase; 110-150 days of gestation) induced by maternal water restriction...
  44. ncbi [Controlled hypernatremia]
    L Petit
    Unité de Réanimation Chirurgicale et Traumatologique, Departement d Anesthesie Reanimation, CHU Pellegrin, 1, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Ann Fr Anesth Reanim 25:828-37. 2006
    b>Hypernatremia exerts its main effect on the brain through the osmotic gradient it creates on either side of the blood brain barrier, which is impermeable to sodium...
  45. ncbi Chronic hypernatremia increases the expression of vasopressin and voltage-gated Na channels in the rat choroid plexus
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI, USA
    Neuroendocrinology 84:339-45. 2006
    ..5 and 295 +/- 2 to 309 +/- 4 mosm/kg H(2)O at 2 days of hypernatremia. This elevated CSF osmolality was maintained at a relatively stable level until the end of a 10-day ..
  46. ncbi Rhabdomyolysis caused by hypernatremia
    Faruk Incecik
    Cukurova University Medical Faculty, Department of Pediatric Neurology, Adana, Turkey
    Indian J Pediatr 73:1124-6. 2006
    ..here it is presented a patient who has biochemical and clinical signs of rhabdomyolysis and admitted to our clinic with hypernatremia. The authors think that it is necessary to be alert for rhabdomyolysis in severe hypernatremia cases.
  47. ncbi Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH
    Landis A Fisher
    Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
    Neurocrit Care 5:180-5. 2006
    ..This study analyzed whether abnormal serum sodium levels are associated with cardiac outcomes and mortality after subarachnoid hemorrhage (SAH)...
  48. doi Seasonal postpartum hypernatremic encephalopathy with osmotic extrapontine myelinolysis and rhabdomyolysis
    Karkal Ravishankar Naik
    Department of Neurology, Jawaharlal Nehru Medical College and KLES Dr Prabhakar Kore Hospital and MRC, Nehrunagar, Belgaum, Karnataka 590010, India
    J Neurol Sci 291:5-11. 2010
    Neurological manifestations secondary to extrapontine myelinolysis and rhabdomyolysis caused by hypernatremia are infrequently reported...
  49. doi Characterization of intensive care unit acquired hyponatremia and hypernatremia following cardiac surgery
    Henry Thomas Stelfox
    Department of Critical Care Medicine, University of Calgary, Foothills Medical Centre, Canada
    Can J Anaesth 57:650-8. 2010
    ..The objective of this study was to describe the epidemiology of ICU-acquired hyponatremia and hypernatremia in patients following cardiac surgery.
  50. ncbi Dehydration and hypernatremia in breast-fed term healthy neonates
    Swarna Rekha Bhat
    Department of Pediatrics, St John s Medical College, Bangalore, India
    Indian J Pediatr 73:39-41. 2006
    The aim of the study was to determine the incidence of significant weight loss, dehydration, hypernatremia and hyperbilirubinemia in exclusively breast-fed term healthy neonates and compare the incidence of these problems in the warm and ..
  51. ncbi Neonatal hypernatremia and dehydration in infants receiving inadequate breastfeeding
    Hassan Boskabadi
    Ghaem Hospital, and Department of Biochemistry and Nutrition, Faculty of Medicine, Mashhad University of Medical Science MUMS, Mashhad, Iran
    Asia Pac J Clin Nutr 19:301-7. 2010
    ..This study looked at the incidence, risk factors, clinical symptoms and complications of NHD in healthy breastfed term neonates...
  52. ncbi Severe hypernatremia after cesarean delivery secondary to transient diabetes insipidus of pregnancy
    David M Sherer
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA
    Obstet Gynecol 102:1166-8. 2003
    ..This condition is considered to result from excess placental vasopressinase activity and is managed with deamino D arginine vasopressin...
  53. doi NFAT5 regulates T lymphocyte homeostasis and CD24-dependent T cell expansion under pathologic hypernatremia
    Rosa Berga-Bolaños
    Immunology Unit, Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona Biomedical Research Park, Barcelona, Spain
    J Immunol 185:6624-35. 2010
    ..We found that NFAT5-null mice had constitutive, pronounced hypernatremia and suffered a severe immunodeficiency, with T cell lymphopenia, altered CD8 naive/memory homeostasis, and ..
  54. ncbi Lateral pontine and extrapontine myelinolysis associated with hypernatremia and hyperglycemia
    R D McComb
    Department of Pathology, University of Nebraska Medical Center, Omaha 68105
    Clin Neuropathol 8:284-8. 1989
    ..We report a woman who presented in hyperosmolar diabetic coma with hypernatremia (169 mEq/l) and hyperglycemia (954 mg/dl)...
  55. ncbi Severe hypernatremia after hypertonic saline irrigation of hydatid cysts
    Aline Albi
    Department of Anesthesiology and Intensive Care Unit, Groupe Hospitalier Cochin, Universite Rene Descartes, Paris, France
    Anesth Analg 95:1806-8, table of contents. 2002
    Patients with iatrogenic hypernatremia and serum sodium levels >170 mmol/L either die or sustain severe central nervous system damage...
  56. ncbi Disorders of water metabolism in children: hyponatremia and hypernatremia
    Michael L Moritz
    Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Rev 23:371-80. 2002
  57. doi Association between hypernatraemia acquired in the ICU and mortality: a cohort study
    Michael Darmon
    Medical Intensive Care Unit, Saint Louis University Hospital, APHP, 1 avenue Claude Vellefaux, Paris, France
    Nephrol Dial Transplant 25:2510-5. 2010
    ..The aim of this study is to describe the prevalence and outcomes of intensive care unit (ICU)-acquired hypernatraemia (IAH)...
  58. ncbi Volume supplementation with iso-sodium solution prevents hypernatremia after head injury
    Y Mizobata
    Osaka Prefectural Senshu Critical Care Medical Center, 2 24 Rinku Orai Kita, Izumisano, Osaka, 598 0048 Japan
    J Trauma 50:871-7. 2001
    To evaluate our developed volume supplement protocol in preventing hypernatremia after head injury.
  59. ncbi Hypodipsic hypernatremia and diabetes insipidus following anterior communicating artery aneurysm clipping: diagnostic and therapeutic challenges in the amnestic rehabilitation patient
    B N Nguyen
    Mississippi Methodist Rehabilitation Center, Jackson, MS, USA
    Brain Inj 15:975-80. 2001
    Hypodipsic hypernatremia (HH) represents a pathological increase in serum sodium due to a lack of thirst and defect in hypothalamic osmoreceptors. While 15% of patients with HH have a vascular aetiology, few cases have been described...
  60. ncbi Natriuresis induced by mild hypernatremia in humans
    Lars Juel Andersen
    Department of Medical Physiology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 282:R1754-61. 2002
    ..The mechanism is uncertain but appears independent of changes in blood pressure, glomerular filtration rate, the renin system, and atrial natriuretic peptide...
  61. ncbi Prognostic significance of hypernatremia and hyponatremia among patients with aneurysmal subarachnoid hemorrhage
    Adnan I Qureshi
    Department of Neurosurgery and Toshiba Stroke Research Center, University at Buffalo, The State University of New York, Buffalo, New York 14209 1194, USA
    Neurosurgery 50:749-55; discussion 755-6. 2002
    Abnormal serum sodium levels (hyponatremia and hypernatremia) are frequently observed during the acute period after aneurysmal subarachnoid hemorrhage (SAH) and may worsen cerebral edema and mass effect...
  62. ncbi Incidence of dehydration and hypernatremia in exclusively breast-fed infants
    R Manganaro
    Neonatology Unit of the University of Messina, 98100 Messina, Italy
    J Pediatr 139:673-5. 2001
    ..RESULTS: Of 686 neonates, 53 (7.7%) had a weight loss > or = 10% of the birth weight, and 19 also had hypernatremia. These 53 neonates had a significantly higher incidence of caesarean delivery and lower maternal education ..
  63. ncbi Severe hypercalcemia and hypernatremia associated with calcipotriol for treatment of psoriasis
    Chie Kawahara
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, 807 8555, Kitakyushu, Japan
    J Bone Miner Metab 22:159-62. 2004
  64. doi Disorders of sodium and water balance in hospitalized patients
    Sean M Bagshaw
    Department of Anesthesiology and Pain Medicine, Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 112 Street, Edmonton, AB, Canada, T6G 2B7
    Can J Anaesth 56:151-67. 2009
    ..To review and discuss the epidemiology, contributing factors, and approach to clinical management of disorders of sodium and water balance in hospitalized patients...
  65. ncbi Extrapontine myelinolysis with involvement of the hippocampus in three children with severe hypernatremia
    W D Brown
    Department of Pediatrics, Rhode Island Hospital, Providence 02903, USA
    J Child Neurol 14:428-33. 1999
    ..Extrapontine myelinolysis has not been described in children previously. We report three children with severe hypernatremia and extrapontine myelinolysis involving various combinations of thalamus, basal ganglia, external and extreme ..
  66. doi Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia
    A Caitlynn Taylor
    Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1285-93. 2008
    ....
  67. pmc The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care units
    Henry Thomas Stelfox
    Department of Critical Care Medicine, University of Calgary, Foothills Medical Centre, EG23, 1403 29 Street NW, Calgary, AB T2N 2T9, Canada
    Crit Care 12:R162. 2008
    ..The objectives of this study were to describe the incidence of ICU-acquired hyponatraemia and hypernatraemia and assess their effects on outcome in the ICU...
  68. ncbi Diabetic ketoacidosis, hyperosmolarity and hypernatremia: are high-carbohydrate drinks worsening initial presentation?
    Ciara M McDonnell
    Department of Endocrinology and Diabetes, Center for Hormone Research, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Pediatr Diabetes 6:90-4. 2005
    ..Each case was complicated by hyperosmolarity and hypernatremia and required intensive therapy...
  69. doi [Electrolyte disorders]
    M Girndt
    Klinik fur Innere Medizin II, Schwerpunkt Nephrologie, Martin Luther Universitat Halle Wittenberg, Ernst Grube Straße 40, 06120 Halle Saale
    Internist (Berl) 52:963-74; quiz 975. 2011
    ..The causes of hypo- or hypernatremia can only be deduced if total body volume status is considered...
  70. pmc Life-threatening hypernatraemic dehydration in breastfed babies
    R Shroff
    Department of Nephrourology, Great Ormond Street Hospital for Children, London, UK
    Arch Dis Child 91:1025-6. 2006
    ..An increased awareness among health professionals is required so that this potentially devastating condition can be prevented...
  71. ncbi Severe hyperosmolarity and hypernatremia in an adipsic young woman
    S Latcha
    Memorial Sloan Kettering Cancer Center, New York, NY 10067, USA
    Clin Nephrol 76:407-11. 2011
    ..arginine vasopressin secretion (AVP) and thirst sensation can result in life threatening hyperosmolality and hypernatremia. Complications include seizures, profound volume contraction and renal failure...
  72. doi Hypernatremia and intravenous fluid resuscitation in collapsed ultramarathon runners
    Tamara Hew-Butler
    Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Clin J Sport Med 18:273-8. 2008
    ....
  73. doi Tonicity balance in patients with hypernatremia acquired in the intensive care unit
    Gregor Lindner
    Department of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Am J Kidney Dis 54:674-9. 2009
    b>Hypernatremia is a serious electrolyte disturbance and an independent risk factor for mortality in critically ill patients. In many cases, hypernatremia is an iatrogenic problem that develops in the intensive care unit (ICU).
  74. doi Intensive care-acquired hypernatremia after major cardiothoracic surgery is associated with increased mortality
    Gregor Lindner
    Department of Anesthesiology, General Intensive Care Medicine and Pain Management, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Intensive Care Med 36:1718-23. 2010
    b>Hypernatremia is common in the medical Intensive Care Unit (ICU) and has been described as an independent risk factor for mortality. Hypernatremia has not yet been studied in a collection of ICU patients after cardiothoracic surgery...
  75. ncbi Risk factors for excess weight loss and hypernatremia in exclusively breast-fed infants
    M K Caglar
    Department of Pediatrics, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
    Braz J Med Biol Res 39:539-44. 2006
    ..and from healthy mothers with no obstetric complication to determine risk factors for excess weight loss and hypernatremia in exclusively breast-fed infants...
  76. ncbi [Physical risks whilst walking the Nijmegen Four Days Marches in 2007: electrolyte imbalance in 1 in 5 walkers]
    T M H Eijsvogels
    Universitair Medisch Centrum St Radboud, Nijmegen
    Ned Tijdschr Geneeskd 152:1571-8. 2008
    ..To determine the physiological impact and health risks for walkers during the Nijmegen (the Netherlands) Four Days Marches in 2007, the largest walking event in the world with more than 45,000 participants...
  77. ncbi Vasopressin and disorders of water balance: the physiology and pathophysiology of vasopressin
    S G Ball
    The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE22 4HH, UK
    Ann Clin Biochem 44:417-31. 2007
    ..Patients with disorders of water balance benefit from a joint clinical and laboratory medicine approach to diagnosis and management...
  78. ncbi Body composition: salt and water
    Jennifer L Ruth
    Pennsylvania State University Children s Hospital, Hershey, PA, USA
    Pediatr Rev 27:181-7; quiz 188. 2006
  79. ncbi The Neonatal Bowel Output Study: indicators of adequate breast milk intake in neonates
    Linda C Shrago
    Mercy Health Center, Oklahoma City, OK, USA
    Pediatr Nurs 32:195-201. 2006
    ....
  80. ncbi [Hyponatremia and hypernatremia]
    Tetsuo Kato
    Nihon Naika Gakkai Zasshi 95:821-5. 2006
  81. doi Approach to fluid and electrolyte disorders and acid-base problems
    Biff F Palmer
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Prim Care 35:195-213, v. 2008
    ..These steps will help to ensure the clinician identifies not only overt abnormalities but also subtle disturbances that may lay hidden in a routine set of serum chemistry values...
  82. doi Reducing the incidence of neonatal hypernatraemic dehydration
    L V A Leven
    Arch Dis Child 93:811. 2008
  83. pmc Reference chart for relative weight change to detect hypernatraemic dehydration
    Paula van Dommelen
    TNO Quality of Life, Leiden, The Netherlands
    Arch Dis Child 92:490-4. 2007
    ..The validity of the rule of thumb that infants may have a weight loss of 10% in the first days after birth is unknown. We assessed the validity of this and other rules to detect breast-fed infants with hypernatraemic dehydration...
  84. ncbi Maternal psychosocial aspects in hypernatremic dehydration with high sodium concentrations in breast milk: a case-control study
    Aylin Ozbek
    Dokuz Eylul University Medical Faculty, Department of Child Psychiatry, Izmir, Turkey
    J Paediatr Child Health 44:38-43. 2008
    ....
  85. ncbi The effect of intravenous magnesium sulfate infusion on serum levels of sodium and potassium in patients with aneurysmal subarachnoid hemorrhage
    George K C Wong
    Division of Neurosurgery, The Chinese University of Hong Kong, Hong Kong
    Magnes Res 20:37-42. 2007
    ..Days of hypernatremia (mean+/-SD) were 2.0+/-2.7 for group 1 and 2.0+/-2.5 for group 2, p = 0...
  86. ncbi Impact of an early weighing policy on neonatal hypernatraemic dehydration and breast feeding
    N P Iyer
    Department of Child Health, Singleton Hospital, Swansea SA2 8QA, West Glamorgan, South Wales, UK
    Arch Dis Child 93:297-9. 2008
    ..To ascertain the effect of a policy of early weighing on the detection and severity of neonatal hypernatraemic dehydration (NHD) and on breastfeeding rates in the short and medium term...
  87. ncbi [Neonatal hypernatraemic dehydration--why increasing incidence?]
    Mette Reilev
    Hvidovre Hospital, Børneafdelingen, Hvidovre
    Ugeskr Laeger 169:1227-31. 2007
    ..Neonatal dehydration with hypernatraemia is a serious condition with risk of cerebral damage and death. Recent studies have reported a rising incidence...
  88. doi Monitoring of newborn weight, breast feeding and severe neurological sequelae secondary to dehydration
    Joe Fawke
    Arch Dis Child 93:264-5. 2008
  89. doi Will changing maintenance intravenous fluid from 0.18% to 0.45% saline do more harm than good?
    M G Coulthard
    Royal Victoria Infirmary, Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Arch Dis Child 93:335-40. 2008
    ..Also, 0.18% saline provides a more physiological standard replacement than 0.45% saline, equivalent to normal oral intakes, and should remain the basic maintenance fluid...
  90. ncbi Hypernatremic dehydration in the newborn period and long-term follow up
    Ebru Ergenekon
    Department of Pediatrics, Division of Newborn Medicine, Gazi University Hospital, Ankara, Turkey
    Pediatr Int 49:19-23. 2007
    ....
  91. doi Nutrition-focused evaluation and management of dysnatremias
    Susan J Whitmire
    Department of Clinical Nutrition Services and Gastroenterology Nutrition, Geisinger Medical Center, Danville, PA 17822 1509, USA
    Nutr Clin Pract 23:108-21. 2008
    ..Dysnatremias (hyponatremia and hypernatremia) merely reflect a relative excess or deficit of plasma water in relation to plasma sodium...
  92. doi Therapeutic approach to electrolyte emergencies
    Michael Schaer
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100126, Gainesville, FL 32610 0126, USA
    Vet Clin North Am Small Anim Pract 38:513-33, x. 2008
    Hypokalemia, hyperkalemia, hyponatremia, hypernatremia, hypocalcemia, and hypercalcemia are commonly seen in emergency medicine...
  93. doi Therapeutic approach to chronic electrolyte disorders
    Michael Willard
    College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4474, USA
    Vet Clin North Am Small Anim Pract 38:535-41, x. 2008
    Chronic disorders of sodium and potassium occur and occasionally need symptomatic therapy. Hypernatremia primarily indicates loss of free water, whereas hyponatremia may be attributable to various problems...
  94. ncbi [Sodium, potassium]
    Yoshihito Ueno
    Division of Clinical Laboratory, Gengendo Kimitsu Hospital
    Nihon Rinsho 62:250-6. 2004
  95. ncbi The controversy over sodium modeling: should we use it or not?
    Michael R Henning
    James Madison University, Harrisonburg, VA, USA
    Nephrol Nurs J 33:505-9. 2006
    ....
  96. ncbi [Aortic and cerebral trombosis caused by hypernatremic dehydration in an exclusively breast-fed infant]
    C Iglesias Fernández
    Sección de Urgencias Pediatría Hospital Infantil Gregorio Marañón Madrid España
    An Pediatr (Barc) 65:381-3. 2006
    ..Early systemic anticoagulation and thrombolytic therapy allowed complete resolution of the problem...
  97. ncbi [How to manage disorders of water balance (dysnatremia)]
    Yugo Shibagaki
    Nihon Jinzo Gakkai Shi 50:76-83. 2008
  98. ncbi Moderate hypernatremic dehydration in newborn infants: retrospective evaluation of 64 cases
    Nurdan Uras
    Department of Pediatrics and Neonatology, Fatih University Faculty of Medicine, Ankara, Turkey
    J Matern Fetal Neonatal Med 20:449-52. 2007
    ..This study was carried out to assess the incidence, presenting complaints, risk factors, and methods for prevention of hypernatremic dehydration among term and near-term breastfeeding infants...
  99. ncbi Treating hypernatremic dehydration
    Andrew L Schwaderer
    Division of Pediatric Nephrology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Pediatr Rev 26:148-50. 2005
  100. ncbi Hypernatraemic dehydration due to high sodium concentrations in breast milk: possible relationship with unwanted pregnancy
    A Kumral
    Acta Paediatr 91:1268-9. 2002
  101. ncbi Hypernatraemic dehydration in Jamaican breastfed neonates: a 12-year review in a baby-friendly hospital
    H Trotman
    Section of Child Health, Department of Obstetrics, Gynaecology and Child Health, University of the West Indies, Mona, Kingston, Jamaica
    Ann Trop Paediatr 24:295-300. 2004
    ..Education programmes are needed to increase awareness amongst health-care workers and mothers in order to prevent the problem...

Research Grants27

  1. Epithelial Sodium Channels in the Supraoptic Vasopressin and Oxytocin Neurons
    Ryoichi Teruyama; Fiscal Year: 2009
    ..addition to the well known effects of OT during parturition and lactation, plasma OT increases in response to hypernatremia (Huang et al., 1995) and induces natriuresis (Conrad et al., 1986;Huang et al., 1994)...
  2. Epithelial Sodium Channels in Vasopressin and Oxytocin Synthesizing Magnocellular
    Ryoichi Teruyama; Fiscal Year: 2013
    ..Plasma OT increases in response to hypernatremia (5) and induces natriuresis (6, 7)...
  3. Molecular and Cellular Regulation of Mammalian Renal Medulla Development
    Jing Yu; Fiscal Year: 2013
    ..Disorders in water and salt balance cause hyponatremia, hypernatremia and nephrogenic diabetes insipidus...
  4. ELECTROPHYSIOLOGICAL CORRELATES OF VASOPRESSIN RELEASE
    William E Armstrong; Fiscal Year: 2011
    ..Dysregulation of VP factors into a range of diseases, from diabetes insipidus and hypernatremia (VP deficiency) to hypertension (excessive release)...
  5. Polymorphism affecting water balance
    David M Cohen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Disorders of water balance (i.e., hypernatremia and hyponatremia) are the most frequently encountered of the electrolyte problems;they are exceedingly common among the elderly, the acutely and ..
  6. Genetics of water balance
    David M Cohen; Fiscal Year: 2013
    ..Through this combination of approaches made possible by NHLBI-supported data generation, we hope to elucidate the human genetic basis for systemic water balance and identify polymorphisms associated with hypo- and hypernatremia.
  7. ASTROCYTE MEDIATED ETHANOL NEUROTOXICITY
    Michael Aschner; Fiscal Year: 2000
    ..organic solutes to maintain cell volume in lieu of a hyperosmotic extracellular fluid (EtOH-induced hypernatremia), as well as a direct stimulatory effect of EtOH on organic osmolyte uptake...
  8. Genetic determinants of water balance in the elderly
    David Cohen; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Disorders of systemic water balance (i.e., hypo- and hypernatremia) are extremely common among the elderly, chronically ill, and hospitalized patients...
  9. Fetal Membrane AQP Expression/Amniotic Fluid Regulation
    Michael Ross; Fiscal Year: 2004
    ..Our objective is to determine the regulatory mechanisms of fetal membrane AQP expression and delineate the role of AQPs in AF homeostasis. ..
  10. Fetal Swallowing: Central Dipsogenic Mechanisms
    Michael Ross; Fiscal Year: 2007
    ..Furthermore, these studies represent a model to examine the development and function of neuronal pathways and mechanisms regulating fetal physiology. ..
  11. PREVENTION AND TREATMENT OF HUMAN OLIGOHYDRAMNIOS
    Michael Ross; Fiscal Year: 2001
    ..e., failure to reset osmolality threshold). This proposal will aid in the development of markers of prediction and therapeutic approaches to the prevention and treatment of human oligohydramnios. ..
  12. LEPTIN & NEUROPEPTIDE-Y ALTERS FETAL SWALLOWING ACTIVITY
    Michael Ross; Fiscal Year: 2002
    ..In addition, these studies represent a model to examine the development and function of neuronal pathways and mechanisms which regulate fetal physiology. ..
  13. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..The goal of this project is to determine critical efficacy and fetal safety issues central to maternal DDAVP treatment, prior to widespread clinical use in human pregnancies with oligohydramnios. ..
  14. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2007
    ..Our preliminary studies of rats indicate that maternal dehydration during pregnancy results in hypernatremia and hypertonicity in the newborn...
  15. CNS AND SALT APPETITE
    DOUGLAS FITTS; Fiscal Year: 2004
    ..of the SFO and the rest of the preoptic area and hypothalamus during intravenous administration of ANG II or hypernatremia by examining the expression of Fos-like immunoreactivity in these brain regions after a disconnection of all ..
  16. HYPONATREMIA-INDUCED OSTEOPOROSIS
    Joseph G Verbalis; Fiscal Year: 2010
    ....
  17. BRAIN OXYTOCIN AND ETHANOL EFFECT ON INGESTIVE BEHAVIOR
    Joseph Verbalis; Fiscal Year: 2001
    ....
  18. Advances in Renal Research: Human Diseases of Protein Processing
    David Ellison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITY
    Joseph Verbalis; Fiscal Year: 2002
    ..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
  20. CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
    STEVEN BEALER; Fiscal Year: 2008
    ..abstract_text> ..
  21. GEORGETOWN UNIVERSITY-MEDSTAR CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE
    Joseph Verbalis; Fiscal Year: 2006
    ..The planning process will be led by a committee of faculty members who are leaders in translational research and clinical research training at the member institutions. [unreadable] [unreadable] [unreadable]..
  22. Altered Baroreflex Responses by Dietary Sodium
    STEVEN BEALER; Fiscal Year: 2003
    ..The work will be performed in the Department of Physiology, University of Tennessee, Memphis, TN 38163. ..
  23. Zinc Neurotoxicity in Traumatic Brain Injury
    Donald Prough; Fiscal Year: 2006
    ..Methodologies: identical to specific aim 1 plus monitoring for signs of neurologic zinc deficiency. ..
  24. Aerosolized PGE1 in Neonatal Pulmonary Hypertension
    BEENA SOOD; Fiscal Year: 2005
    ..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
  25. A Renal Epithelial Urea Sensor
    David Cohen; Fiscal Year: 2005
    ..In addition, the sufficiency of these and related signaling elements for urea signaling will be examined in models of heterologous expression. ..
  26. Expression of TRPV1 and variant TRPV1 in the kidney
    David Cohen; Fiscal Year: 2005
    ..In addition, such a reagent might have potential therapeutic utility with respect to this important pathway mediating nociception. ..
  27. Modulation of Electrogenic Sodium Bicarbonate Transport
    Ira Kurtz; Fiscal Year: 2007
    ..Successful completion of this project will enhance our understanding of the mechanisms responsible for regulating H+/base transporters. ..