wasting syndrome

Summary

Summary: Any disease marked especially by progressive emaciation and weakness. (Dorland, 28th ed, p490)

Top Publications

  1. ncbi Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 42:864-81. 2003
  2. ncbi A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease
    D Fouque
    Department of Nephrology, Hopital Edouard Herriot, Universite Lyon 1, U870 INSERM, Lyon, France
    Kidney Int 73:391-8. 2008
  3. ncbi Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2
    T Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Vet Pathol 41:624-40. 2004
  4. ncbi Prevalence of swine Torque teno virus in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs in Spain
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Gen Virol 87:833-7. 2006
  5. ncbi Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM)
    Juan Jesus Carrero
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Solna, Sweden
    J Ren Nutr 23:77-90. 2013
  6. ncbi Case-control study on the association of porcine circovirus type 2 and other swine viral pathogens with postweaning multisystemic wasting syndrome
    Roman M Pogranichniy
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames 50011, USA
    J Vet Diagn Invest 14:449-56. 2002
  7. pmc Quantitative, competitive PCR analysis of porcine circovirus DNA in serum from pigs with postweaning multisystemic wasting syndrome
    Q Liu
    Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
    J Clin Microbiol 38:3474-7. 2000
  8. ncbi The use of c-src knockout mice for the identification of the main toxic signaling pathway of TCDD to induce wasting syndrome
    Christoph F A Vogel
    Department of Environmental Toxicology and the Center for Environmental Health Sciences, University of California, Davis, CA 95616, USA
    J Biochem Mol Toxicol 17:305-15. 2003
  9. ncbi Clinical pathologic changes in two marmosets with wasting syndrome
    A C Logan
    Searle R and D, Skokie, Illinois 60077, USA
    Toxicol Pathol 24:707-9. 1996
  10. pmc IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting
    Liping Zhang
    Nephrology Division, Baylor College of Medicine, Houston, TX 77030, USA
    J Am Soc Nephrol 20:604-12. 2009

Detail Information

Publications193 found, 100 shown here

  1. ncbi Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences
    Kamyar Kalantar-Zadeh
    Division of Nephrology and Hypertension, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 42:864-81. 2003
    ..Clinical trials focusing on MICS and its possible causes and consequences are urgently required to improve poor clinical outcome in dialysis patients...
  2. ncbi A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease
    D Fouque
    Department of Nephrology, Hopital Edouard Herriot, Universite Lyon 1, U870 INSERM, Lyon, France
    Kidney Int 73:391-8. 2008
    ..Clinical staging and potential treatment strategies for protein-energy wasting are to be developed in the future...
  3. ncbi Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2
    T Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Vet Pathol 41:624-40. 2004
    ..lymphadenitis associated with high amounts of PCV2-antigen consistent with postweaning multisystemic wasting syndrome (PMWS). PCV2-antigen in lung tissue was most often associated with M...
  4. ncbi Prevalence of swine Torque teno virus in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs in Spain
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Gen Virol 87:833-7. 2006
    ..was designed to investigate the prevalence of swine Torque teno virus (TTV) in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-affected Spanish swine...
  5. ncbi Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM)
    Juan Jesus Carrero
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Solna, Sweden
    J Ren Nutr 23:77-90. 2013
    ..In addition, comorbid conditions associated with CKD, poor physical activity, frailty, and the dialysis procedure per se further contribute to PEW...
  6. ncbi Case-control study on the association of porcine circovirus type 2 and other swine viral pathogens with postweaning multisystemic wasting syndrome
    Roman M Pogranichniy
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames 50011, USA
    J Vet Diagn Invest 14:449-56. 2002
    ..association of porcine circovirus type 2 (PCV2) and some major swine viruses with postweaning multisystemic wasting syndrome (PMWS)...
  7. pmc Quantitative, competitive PCR analysis of porcine circovirus DNA in serum from pigs with postweaning multisystemic wasting syndrome
    Q Liu
    Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
    J Clin Microbiol 38:3474-7. 2000
    ..While PCV1 was detected in only 3 of 16 pigs with postweaning multisystemic wasting syndrome (PMWS), all the sick piglets contained PCV2...
  8. ncbi The use of c-src knockout mice for the identification of the main toxic signaling pathway of TCDD to induce wasting syndrome
    Christoph F A Vogel
    Department of Environmental Toxicology and the Center for Environmental Health Sciences, University of California, Davis, CA 95616, USA
    J Biochem Mol Toxicol 17:305-15. 2003
    ..These observations support the notion that c-Src is an important mediator of the effects of TCDD on TGFalpha, PDGF(AA), and C/EBPalpha, beta...
  9. ncbi Clinical pathologic changes in two marmosets with wasting syndrome
    A C Logan
    Searle R and D, Skokie, Illinois 60077, USA
    Toxicol Pathol 24:707-9. 1996
    ..The principal gross and histopathologic finding was chronic colitis, which appeared to be the most important contributing factor to the development of wasting syndrome in these marmosets.
  10. pmc IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting
    Liping Zhang
    Nephrology Division, Baylor College of Medicine, Houston, TX 77030, USA
    J Am Soc Nephrol 20:604-12. 2009
    ..Targeting the high levels of IL-6 and SAA in catabolic disorders might be a therapeutic approach to prevent muscle wasting...
  11. ncbi Prevalence and predictors of underweight, stunting, and wasting among children aged 5 and under in western Kenya
    Emily Bloss
    School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
    J Trop Pediatr 50:260-70. 2004
    ..Emphasis should be placed on current immunization, prolonging exclusive breastfeeding, and improving access to nutrient-rich foods among adopted children and their families via community-based nutrition interventions...
  12. ncbi Detection of porcine circovirus type 2, porcine parvovirus and porcine pseudorabies virus from pigs with postweaning multisystemic wasting syndrome by multiplex PCR
    S Cao
    Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China
    Vet Res Commun 29:263-9. 2005
    ..virus (PRV) and applied to samples from 137 piglets exhibiting clinical signs of postweaning multisystemic wasting syndrome (PMWS). PCV-2 DNA was detected from all samples...
  13. ncbi Quantification of porcine circovirus type 2 (PCV2) DNA in serum and tonsillar, nasal, tracheo-bronchial, urinary and faecal swabs of pigs with and without postweaning multisystemic wasting syndrome (PMWS)
    J Segales
    Departament de Sanitat i d Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 111:223-9. 2005
    ....
  14. ncbi Cytokine mRNA expression profiles in lymphoid tissues of pigs naturally affected by postweaning multisystemic wasting syndrome
    Laila Darwich
    Departament de Sanitat i d Anatomia Animals Unitat de Malalties Infeccioses, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Gen Virol 84:2117-25. 2003
    ..conventional pigs were selected from a farm where pigs were suffering from postweaning multisystemic wasting syndrome (PMWS)...
  15. ncbi Induction of cachexia in mice by systemically administered myostatin
    Teresa A Zimmers
    Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 296:1486-8. 2002
    ..These data indicate that myostatin acts systemically in adult animals and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired...
  16. ncbi Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs
    Alex Olvera
    Centre de Recerca en Sanitat Animal, Campus Universitari de Bellaterra, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    J Virol Methods 117:75-80. 2004
    Postweaning multisystemic wasting syndrome (PMWS) diagnosis is based on the presence of characteristic histopathological lymphoid lesions and porcine circovirus type 2 (PCV2) within these lesions...
  17. ncbi Porcine circovirus type 2 (PCV-2) coinfections in US field cases of postweaning multisystemic wasting syndrome (PMWS)
    F J Pallares
    Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Iowa State University, Ames 50011, USA
    J Vet Diagn Invest 14:515-9. 2002
    ..porcine circovirus type 2 (PCV-2) was studied retrospectively in field cases of postweaning multisystemic wasting syndrome (PMWS) diagnosed at the Iowa State University Veterinary Diagnostic Laboratory, Ames, Iowa, between January ..
  18. ncbi Identification of postweaning multisystemic wasting syndrome in European wild boar (Sus scrofa)
    C Schulze
    Landeslabor Brandenburg, Ringstrasse 1030, D 15236 Frankfurt Oder, Germany
    Vet Rec 154:694-6. 2004
  19. pmc Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34
    Vrajesh V Parekh
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 190:5086-101. 2013
    ..Furthermore, aged animals developed an inflammatory wasting syndrome characterized by weight loss, intestinal inflammation, and anemia...
  20. ncbi Dynamics of porcine circovirus type 2 infection in a herd of pigs with postweaning multisystemic wasting syndrome
    Gabriela M Rodríguez-Arrioja
    Centre de Recerca en Sanitat Animal, Departament de Sanitat i d Anatomia Animals, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Am J Vet Res 63:354-7. 2002
    To determine the pattern of infection for porcine circovirus type 2 (PCV2) in a herd of pigs with postweaning multisystemic wasting syndrome (PMWS).
  21. pmc Changes in CD4(+), CD8(+), CD4(+) CD8(+), and immunoglobulin M-positive peripheral blood mononuclear cells of postweaning multisystemic wasting syndrome-affected pigs and age-matched uninfected wasted and healthy pigs correlate with lesions and porcine ci
    Laila Darwich
    Departament de Sanitat i d Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Clin Diagn Lab Immunol 9:236-42. 2002
    ..wasted pigs were selected from several conventional farms with histories of postweaning multisystemic wasting syndrome (PMWS) and classified into two groups according to their porcine circovirus type 2 (PCV2) infection status, ..
  22. ncbi The effects of immuno-modulation on the clinical and pathological expression of postweaning multisystemic wasting syndrome
    S C Kyriakis
    Clinic of Productive Animal Medicine, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 540 06 Thessaloniki, Macedonia, Greece
    J Comp Pathol 126:38-46. 2002
    Post-weaning multisystemic wasting syndrome (PMWS), primarily caused by porcine circovirus type 2 (PCV-2), is an economically important disease of pigs in many countries...
  23. ncbi Infection, excretion and seroconversion dynamics of porcine circovirus type 2 (PCV2) in pigs from post-weaning multisystemic wasting syndrome (PMWS) affected farms in Spain and Denmark
    Llorenç Grau-Roma
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 135:272-82. 2009
    Longitudinal case-control studies were performed in post-weaning multisystemic wasting syndrome (PMWS) affected farms from Denmark and Spain using similar designs...
  24. ncbi Differentiation of porcine circovirus 1 and 2 in formalin-fixed, paraffin-wax-embedded tissues from pigs with postweaning multisystemic wasting syndrome by in-situ hybridisation
    J Kim
    Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, Republic of Korea
    Res Vet Sci 70:265-9. 2001
    ..From the 40 field cases with postweaning multisystemic wasting syndrome tested by in-situ hybridisation, 30 (75 per cent) cases were PCV2-positive only and 10 (25 per cent) cases ..
  25. ncbi Porcine reproductive and respiratory syndrome virus (PRRSV) infection status in pigs naturally affected with post-weaning multisystemic wasting syndrome (PMWS) in Spain
    Joaquim Segales
    Centre de Recerca en Sanitat Animal CReSA, Departament de Sanitat i d Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 85:23-30. 2002
    ..porcine reproductive and respiratory syndrome virus (PRRSV) in pigs affected with post-weaning multisystemic wasting syndrome (PMWS), a disease believed to be caused by porcine circovirus type 2 (PCV2)...
  26. ncbi Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice
    C Veltkamp
    Center for GI Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27599-7038, USA
    Gastroenterology 120:900-13. 2001
    ..Moreover, pathogenic T cells require the continuous presence of colonic bacteria to sustain colitis...
  27. ncbi Detection and genetic characterization of porcine circovirus type 2 (PCV2) in pigs from Croatia
    L Jemersic
    Virology Department, Croatian Veterinary Institute, Savska cesta 143, 10000 Zagreb, Croatia
    Res Vet Sci 77:171-5. 2004
    ..family has recently been associated with two serious diseases of swine, post-weaning multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS)...
  28. ncbi Postweaning multisystemic wasting syndrome in pigs in Venezuela
    J P Cano
    Vet Rec 156:620. 2005
  29. ncbi Potentiation of porcine circovirus 2-induced postweaning multisystemic wasting syndrome by porcine parvovirus is associated with excessive production of tumor necrosis factor-alpha
    J Kim
    Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, Kwanak gu, Republic of Korea
    Vet Pathol 43:718-25. 2006
    This study investigated the potentiation of porcine circovirus 2 (PCV2)-induced postweaning multisystemic wasting syndrome by porcine parvovirus (PPV) and found it was associated with excessive production of tumor necrosis factor-alpha (..
  30. pmc The prevalence of stunting is high in HIV-1-exposed uninfected infants in Kenya
    Christine J McGrath
    Departments of Epidemiology, University of Washington, Seattle, WA, USA
    J Nutr 142:757-63. 2012
    ..Because BF is the best option for HIV-1-infected mothers in resource-limited settings, nutritional interventions should be examined for their impact on growth in EU breast-fed infants...
  31. ncbi [Three cases of postweaning multisystemic wasting syndrome (PMWS) due to porcine circovirus type 2 (PCV 2) in Switzerland.]
    N Borel
    ,
    Schweiz Arch Tierheilkd 143:249-55. 2001
    ..Circoviral DNA was detected in the lymphatic organs as well as in the liver. This case report is the first description of PCV 2 in Switzerland...
  32. ncbi First report of post-weaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome in pigs in Greece
    K Saoulidis
    Clinic of Productive Animal Medicine, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece
    J Vet Med B Infect Dis Vet Public Health 49:202-5. 2002
    Post-weaning multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS) are two recently described conditions of pigs at the late nursery and fattening stages...
  33. ncbi A systematic review of the evidence on symptom management of cancer-related anorexia and cachexia
    Jean K Brown
    University of Buffalo, State University of New York, NY, USA
    Oncol Nurs Forum 29:517-32. 2002
    ..To evaluate and synthesize the evidence regarding cancer-related anorexia and cachexia symptom management and make recommendations for future directions...
  34. ncbi [Pathological findings in pigs affected by the postweaning multisystemic wasting syndrome in Argentina]
    J Sarradell
    Facultad de Cs Veterinarias Ov Lagos y Ruta 33, 2170 Casilda, Argentina
    Rev Argent Microbiol 36:118-24. 2004
    Postweaning multisystemic wasting syndrome was first described in Canada in 1991 and at present an increasing number of cases has been diagnosed worldwide. In Argentina the first cases of PMWS were reported recently...
  35. ncbi Evaluation of a porcine circovirus type 2-specific antigen-capture enzyme-linked immunosorbent assay for the diagnosis of postweaning multisystemic wasting syndrome in pigs: comparison with virus isolation, immunohistochemistry, and the polymerase chain r
    F McNeilly
    Department of Agriculture and Rural Development for Northern Ireland, Veterinary Sciences Division, Stormont, Belfast
    J Vet Diagn Invest 14:106-12. 2002
    ..Tissue samples from pigs experimentally infected with PCV2 and field cases of postweaning multisystemic wasting syndrome and PCV2-associated reproductive disorders were used in this evaluation...
  36. ncbi Wasting and body composition of adults with pulmonary tuberculosis in relation to HIV-1 coinfection, socioeconomic status, and severity of tuberculosis
    E Villamor
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Clin Nutr 60:163-71. 2006
    ..To examine the impact of HIV coinfection, socioeconomic status (SES) and severity of tuberculosis (TB) on the body composition and anthropometric status of adults with pulmonary TB...
  37. ncbi Postweaning multisystemic wasting syndrome (PMWS) in the Philippines: porcine circovirus type 2 (PCV2) detection and characterization
    Jaime Maldonado
    Laboratorios Hipra, S A, Girona, Spain
    J Vet Med Sci 66:533-7. 2004
    ..the Philippines, showed lesions and clinical signs similar to those described in post weaning multisystemic wasting syndrome (PMWS)...
  38. pmc Association of maternal height with child mortality, anthropometric failure, and anemia in India
    S V Subramanian
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA 02115, USA
    JAMA 301:1691-701. 2009
    ..Research on intergenerational factors that might also predispose a child to increased health adversity remains limited...
  39. ncbi Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease
    Joaquim Segales
    Centre de Recerca en Sanitat Animal CReSA, Departament de Sanitat i d Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 98:137-49. 2004
    ..PCV2) is a novel virus of the Circoviridae family which is considered the cause of postweaning multisystemic wasting syndrome (PMWS)...
  40. ncbi Clinical and pathological observations on pigs with postweaning multisystemic wasting syndrome
    J Quintana
    Centre de Recerca en Sanitat Animal, Departament de Sanitat i Anatomia Animals, , Bellaterra, Spain
    Vet Rec 149:357-61. 2001
    ..in clinically normal and clinically affected pigs on a farm during an outbreak of postweaning multisystemic wasting syndrome (PMWS), and to evaluate the diagnostic techniques for detecting porcine circovirus type 2 (PCV-2) and other ..
  41. ncbi The biological mechanisms of cancer-related skeletal muscle wasting: the role of progressive resistance exercise
    Sadeeka Al-Majid
    Adult Health Department, Virginia Commonwealth University, Richmond, VA 23298, USA
    Biol Res Nurs 10:7-20. 2008
    ..This article discusses several cancer-related skeletal muscle wasting mechanisms and proposes how PRT might attenuate muscle wasting by counteracting some of these mechanisms...
  42. ncbi Cerebral salt wasting syndrome following neurosurgical intervention in tuberculous meningitis
    L Nagotkar
    Pediatric Intensive Care Unit, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai 400 022, India
    Indian Pediatr 45:598-601. 2008
    ..The first patient was managed with rigorous salt and water replacement whereas the second patient required the addition of fludrocortisone for control of salt-wasting...
  43. pmc Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2
    A Rovira
    Centre de Recerca en Sanitat Animal CReSA, Departament de Sanitat i d Anatomia Animals, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Virol 76:3232-9. 2002
    Postweaning multisystemic wasting syndrome (PMWS) is a disease of nursery and fattening pigs characterized by growth retardation, paleness of the skin, dyspnea, and increased mortality rates...
  44. ncbi Pathogenesis of postweaning multisystemic wasting syndrome caused by Porcine circovirus 2: An immune riddle
    L Darwich
    Departament Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Arch Virol 149:857-74. 2004
    Postweaning multisystemic wasting syndrome (PMWS) is a disease of pigs first recognised in North America in 1997 and subsequently reported worldwide that is caused by Porcine circovirus 2 (PCV2), a member of the family Circoviridae...
  45. ncbi Evidence of breed-dependent differences in susceptibility to porcine circovirus type-2-associated disease and lesions
    T Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Vet Pathol 43:281-93. 2006
    Porcine circovirus type 2 (PCV2) has been confirmed as the primary cause of postweaning multisystemic wasting syndrome (PMWS). However, in the field, PMWS is seen only in a small percentage of pigs infected with PCV2...
  46. ncbi An ORF2 protein-based ELISA for porcine circovirus type 2 antibodies in post-weaning multisystemic wasting syndrome
    Ph Blanchard
    Agence Francaise de Securite Sanitaire des Aliments, BP 53, Fr 22440 Ploufragan, France
    Vet Microbiol 94:183-94. 2003
    Porcine circovirus type 2 (PCV2) plays a crucial role in the pathogenesis of post-weaning multisystemic wasting syndrome (PMWS) in swine...
  47. ncbi PMWS: experimental model and co-infections
    G M Allan
    Virology Department, Veterinary Research Laboratory, Veterinary Sciences Division, Stoney Road Stormont, DARDNI, Stormont, BT4 SD Belfast, Northern Ireland, UK
    Vet Microbiol 98:165-8. 2004
    Porcine circovirus type 2 (PCV2) is now recognised as the causal agent of porcine multisystemic wasting syndrome (PMWS), an economically important wasting disease of young pigs [J. Vet. Diagn. Invest. 12 (2000) 3]...
  48. pmc Adoptively transferred dendritic cells restore primary cell-mediated inflammatory competence to acutely malnourished weanling mice
    Lyn Hillyer
    Department of Human Health and Nutritional Sciences, University of Guelph, ON, Canada N1G 2W1
    Am J Pathol 172:378-85. 2008
    ..Thus, a new dendritic cell-centered perspective emerges regarding the cellular mechanism underlying immune depression in acute pediatric protein and energy deficit...
  49. ncbi Molecular characterization of Porcine circovirus type 2 isolates from post-weaning multisystemic wasting syndrome-affected and non-affected pigs
    Claire de Boisseson
    French Food Safety Agency, Viral Genetics and Biosafety Unit, BP 53, F 22 440 Ploufragan, France
    J Gen Virol 85:293-304. 2004
    Porcine circovirus type 2 (PCV2) is recognized as a primary cause in post-weaning multisystemic wasting syndrome (PMWS)...
  50. ncbi Experimental reproduction of postweaning multisystemic wasting syndrome (PMWS) in pigs in Sweden and Denmark with a Swedish isolate of porcine circovirus type 2
    F Hasslung
    Department of Molecular Biosciences, Section of Veterinary Immunology and Virology, Swedish University of Agricultural Sciences, Biomedical Centre, PO Box 588, SE 751 23 Uppsala, Sweden
    Vet Microbiol 106:49-60. 2005
    ..is at present one of the best methods to study factors affecting development of postweaning multisystemic wasting syndrome (PMWS)...
  51. ncbi Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2)
    S Krakowka
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, USA
    Vet Pathol 38:31-42. 2001
    ..described single-stranded circular DNA virus pathogen of swine is the cause of postweaning multisystemic wasting syndrome (PMWS)...
  52. pmc Detection of porcine circovirus types 1 and 2 in serum and tissue samples of pigs with and without postweaning multisystemic wasting syndrome
    Maria Calsamiglia
    Centre de Recerca en Sanitat Animal CReSA, Campus Universitari Bellaterra, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Clin Microbiol 40:1848-50. 2002
    ..1 (PCV1) and PCV2 was studied in sera and superficial inguinal lymph nodes from postweaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs by using in situ hybridization and PCR...
  53. ncbi Subcellular immunolocalization of porcine circovirus type 2 (PCV2) in lymph nodes from pigs with post-weaning multisystemic wasting syndrome (PMWS)
    C Rodríguez-Cariño
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA and Departament de Sanitat i Anatomia Animals, Facultat de Veterinaria, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Comp Pathol 142:291-9. 2010
    Post-weaning multisystemic wasting syndrome (PMWS) is one of the most significant porcine diseases worldwide. The causative agent is porcine circovirus type 2 (PCV2), the smallest virus known to infect animals...
  54. ncbi Porcine circovirus diseases
    Joaquim Segales
    Virology Department, Veterinary Research Laboratory, Veterinary Sciences Division, Stoney Road Stormont, DARDNI, Stormont, BT4 SD Belfast, Northern Ireland, UK
    Anim Health Res Rev 6:119-42. 2005
    ..Postweaning multisystemic wasting syndrome (PMWS), porcine dermatitis and nephropathy syndrome (PDNS) and reproductive disorders are the most relevant ..
  55. ncbi Detection of porcine circovirus 2 (PCV-2) DNA by nested PCR from formalin-fixed tissues of post-weaning multisystemic wasting syndrome (PMWS) pigs in Thailand
    Wijit Kiatipattanasakul-Banlunara
    Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand
    J Vet Med Sci 64:449-52. 2002
    ..circovirus 2 (PCV-2) DNA was conducted by nested PCR method in 16 cases of swine post-weaning multisystemic wasting syndrome (PMWS) in Thailand...
  56. ncbi Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology
    C Chae
    Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, San 56 1, Shillim Dong, Kwanak Gu 151 742, Seoul, South Korea
    Vet J 168:41-9. 2004
    ..review paper concentrates on the aetiology, diagnosis, and pathological aspects of postweaning multisystemic wasting syndrome (PMWS)...
  57. ncbi Ultrastructural findings in lymph nodes from pigs suffering from naturally occurring postweaning multisystemic wasting syndrome
    C Rodríguez-Cariño
    Departament de Sanitat i Anatomia Animals, Centre de Recerca en Sanitat Animal, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Pathol 46:729-35. 2009
    The aims of this study were to evaluate ultrastructural lesions in lymph nodes from postweaning multisystemic wasting syndrome (PMWS)-affected pigs and to correlate these alterations with detection of viral-like particles (VLPs)...
  58. ncbi A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant
    Arne M Nystuen
    Department of Genetics, Cell Biology and Anatomy, 6008 Durham Research Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Neurogenetics 8:1-10. 2007
    ..Taken together, these data indicate that VAMP1 has a vital role in a subset of central nervous system tissues...
  59. ncbi Viral wasting syndrome of swine: experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus
    S Krakowka
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, USA
    Vet Pathol 37:254-63. 2000
    ..Piglets were evaluated for 1) the development of porcine postweaning multisystemic wasting syndrome (PMWS), 2) distribution of viral antigens by immunochemistry, and 3) viremia and the presence of viral DNA in ..
  60. ncbi Overabundance of CD45RA(+) (quiescent-phenotype) cells within the involuted CD4(+) T-cell population follows initiation of immune depression in energy-deficient weanling mice and reflects involution exclusive to the CD45RA(-) subset
    C L Ha
    Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science, Jen-Ter Hsiang, Tainan 71710, Taiwan
    J Nutr 131:1812-8. 2001
    ..Remarkably, this imbalance develops because involution of the CD4(+) subset in the energy-deficient mice is confined to the CD45RA(-) population...
  61. ncbi Characterisation of PCV-2 isolates from Spain, Germany and France
    A Mankertz
    Robert Koch Institut, P24 Xenotransplantation, Nordufer 20, 13353, Berlin, Germany
    Virus Res 66:65-77. 2000
    ..agent of a new emerging swine disease with a variable morbidity and high lethality, postweaning multisystemic wasting syndrome (PMWS). PMWS has been diagnosed in North America and West Europe...
  62. ncbi Systemic cytokine profile in feeder pigs suffering from natural postweaning multisystemic wasting syndrome (PMWS) as determined by semiquantitative RT-PCR and flow cytometric intracellular cytokine detection
    W Sipos
    II Medical Clinic for Ruminants and Swine, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Vet Immunol Immunopathol 99:63-71. 2004
    Postweaning multisystemic wasting syndrome (PMWS) is an economically important disease in pigs caused by porcine circovirus type 2 (PCV2). Development of this disease is presumably associated with an impairment of the immune system...
  63. ncbi Protein-energy malnutrition among preschool children in Oman: results of a national survey
    D Alasfoor
    Department of Nutrition, Ministry of Health, Muscat, Oman
    East Mediterr Health J 13:1022-30. 2007
    ..Data were analysed according to the World Health Organization protocols. The prevalence rates of wasting, stunting and underweight were 7.0%, 10.6% and 17.9% respectively at the national level. There were no sex differences...
  64. ncbi Infection of pigs in Ireland with lymphotropic gamma-herpesviruses and relationship to postweaning multisystemic wasting syndrome
    Kenneth J McMahon
    School of Biotechnology and National Centre for Sensor Research, Dublin City University, Dublin 9, Ireland
    Vet Microbiol 116:60-8. 2006
    ..with PLHVs was linked to the development of porcine circovirus-2 (PCV2)-associated postweaning mutlisystemic wasting syndrome (PMWS), a disease characterised in part by histopathological lesions in lymphoid tissues...
  65. ncbi Spatial and temporal patterns of pig herds diagnosed with Postweaning Multisystemic Wasting Syndrome (PMWS) during the first two years of its occurrence in Denmark
    Håkan Vigre
    The Danish Institute for Food and Veterinary Research, Department of Epidemiology and Risk Assessment, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Vet Microbiol 110:17-26. 2005
    The clinical syndrome Postweaning Multisystemic Wasting Syndrome (PMWS) in pigs has emerged globally during the last decade...
  66. ncbi Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice
    S C Cipriano
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 141:2319-27. 2000
    ..Overproduction of activins in the serum directly causes a cachexia-like wasting syndrome that results in lethality of these mice at an early stage after the onset of the tumors...
  67. ncbi Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria
    Shigeyuki Uno
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Toxicol Appl Pharmacol 196:410-21. 2004
    ..than 4 weeks to Cyp1a1(+/+) males but not to Cyp1a1(-/-) males or to females of either genotype; (b) caused a wasting syndrome in Cyp1a1(+/+) but not Cyp1a1(-/-) mice; (c) resulted in thymic atrophy, regardless of gender or genotype; (d)..
  68. ncbi Expression of monocyte chemoattractant protein-1 but not interleukin-8 in granulomatous lesions in lymph nodes from pigs with naturally occurring postweaning multisystemic wasting syndrome
    J Kim
    Department of Veterinary Pathology, College of Veterinary Medicine asnd School of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
    Vet Pathol 40:181-6. 2003
    ..probe in granulomatous lesions of lymph nodes from 20 pigs with naturally occurring postweaning multisystemic wasting syndrome (PMWS)...
  69. ncbi Descriptive summary of an outbreak of porcine post-weaning multisystemic wasting syndrome (PMWS ) in New Zealand
    E J Neumann
    Epicentre, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    N Z Vet J 55:346-52. 2007
    ..A definition for post-weaning multisystemic wasting syndrome (PMWS) including both clinical and pathological features, previously developed for the pig industry in New ..
  70. ncbi Influence of wasting and stunting at the onset of the rainy season on subsequent malaria morbidity among rural preschool children in Senegal
    Florie Fillol
    Epidemiology and Prevention Research Unit, Institut de Recherche pour le Developpement, Montpellier, France
    Am J Trop Med Hyg 80:202-8. 2009
    ..Although non-biological explanations such as overprotection of wasted children by their mothers should be considered, immunomodulation according to nutritional status could explain the lower risk of malaria attack among wasted children...
  71. ncbi An exploratory study on risk factors for postweaning multisystemic wasting syndrome (PMWS) in Spain
    S López-Soria
    Centre de Recerca en Sanitat Animal CReSA, Departament de Sanitat i d Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona UAB, E 08193 Bellaterra, Barcelona, Spain
    Prev Vet Med 69:97-107. 2005
    ..systems to assess risk factors that, in association with PCV2 infection, induce postweaning multisystemic wasting syndrome (PMWS) expression...
  72. ncbi Comparison of the new World Health Organization growth standards and the National Center for Health Statistics growth reference regarding mortality of malnourished children treated in a 2006 nutrition program in Niger
    Nancy M Dale
    Department of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Arch Pediatr Adolesc Med 163:126-30. 2009
    ..To compare the National Centre for Health Statistics (NCHS) international growth reference with the new World Health Organization (WHO) growth standards for identification of the malnourished (wasted) children most at risk of death...
  73. ncbi Haptoglobin and pig-major acute protein are increased in pigs with postweaning multisystemic wasting syndrome (PMWS)
    Joaquim Segales
    Centre de Recerca en Sanitat Animal CReSA, Departament de Sanitat i d Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Res 35:275-82. 2004
    ..proteins (APP), haptoglobin (HPT) and pig-major acute phase protein (pig-MAP), in postweaning multisystemic wasting syndrome (PMWS) affected pigs and PCV2-subclinically infected pigs...
  74. ncbi Detection of neutralizing antibodies in postweaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs
    Maria Fort
    Centre de Recerca en Sanitat Animal CReSA, Esfera UAB, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 125:244-55. 2007
    The notion that postweaning multisystemic wasting syndrome (PMWS)-affected pigs develop an impaired humoral response against porcine circovirus type 2 (PCV2) has been reported in several studies...
  75. ncbi Postweaning multisystemic wasting syndrome--PMWS. the first year with the disease in Sweden
    P Wallgren
    National Veterinary Institute, SVA, 751 89 Uppsala, Sweden
    Vet Q 26:170-87. 2004
    Postweaning multisystemic wasting syndrome (PMWS) is causally associated with porcine circovirus type 2 (PCV2) infection of pigs. PCV2 has been present in the Swedish pig population for at least ten years...
  76. ncbi Quantitation of porcine circovirus type 2 isolated from serum/plasma and tissue samples of healthy pigs and pigs with postweaning multisystemic wasting syndrome using a TaqMan-based real-time PCR
    Inger Marit Brunborg
    Section for Virology and Serology, National Veterinary Institute, P O Box 8156, N 0033 Oslo, Norway
    J Virol Methods 122:171-8. 2004
    ..In this context, postweaning multisystemic wasting syndrome (PMWS) has emerged as a significant disease...
  77. pmc Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome
    J Ellis
    Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon
    Can Vet J 39:44-51. 1998
    Postweaning multisystemic wasting syndrome (PMWS), an apparently new disease, has been recognized in swine herds in western Canada...
  78. ncbi Immunosuppression in postweaning multisystemic wasting syndrome affected pigs
    Joaquim Segales
    Departament de Sanitat i d Anatomia Animals, Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Barcelona, Spain
    Vet Microbiol 98:151-8. 2004
    ..From these points of view, strong suspicions on the immunosuppressive status of PMWS affected pigs do exist; however, future studies are needed to characterise the exact role of PCV2 on the immune system of pigs affected with PMWS...
  79. ncbi Postweaning multisystemic wasting syndrome of pigs in Korea: prevalence, microscopic lesions and coexisting microorganisms
    Junghyun Kim
    Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Kyouggi Do, Republic of Korea
    J Vet Med Sci 64:57-62. 2002
    A retrospective study was performed on natural cases of postweaning multisystemic wasting syndrome (PMWS), recorded from January 1999 to December 2000, to determine the prevalence, microscopic lesions, and other coexisting pathogens ..
  80. ncbi Immunohistochemical characterisation of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS)
    F Chianini
    Centre de Recerca en Sanitat Animal CReSA, Departament de Sanitat i Anatomia Animals Universitat Autónoma de Barcelona, Bellaterra, 08193 Barcelona, Spain
    Vet Immunol Immunopathol 94:63-75. 2003
    The lymphoid, renal, pulmonary, and hepatic lesions of naturally occurring postweaning multisystemic wasting syndrome (PMWS) affected pigs have been studied by means of immunohistology...
  81. pmc Comparative serologic and virologic study of commercial swine herds with and without postweaning multisystemic wasting syndrome
    Renée Larochelle
    Laboratoire d Hygiène vétérinaire et alimentaire, Agence canadienne d inspection des aliments, 3400 Casavant ouest, St Hyacinthe, Quebec J2S 8E3
    Can J Vet Res 67:114-20. 2003
    A comparative serologic and virologic study was performed in pigs from 5 herds with postweaning multisystemic wasting syndrome (PMWS) and 2 herds without PMWS in Quebec...
  82. ncbi Risk factors for porcine post-weaning multisystemic wasting syndrome (PMWS) in 149 French farrow-to-finish herds
    N Rose
    AFSSA site de Ploufragan, Laboratoire Central de Recherches, Avicole et Porcine, B P 53, 22440 Ploufragan, France
    Prev Vet Med 61:209-25. 2003
    ..farms was carried out in France in 2000 and 2001 to assess the risk factors for post-weaning multisystemic wasting syndrome (PMWS)...
  83. ncbi Immunohistochemical characterisation of the lymph node reaction in pig post-weaning multisystemic wasting syndrome (PMWS)
    G Sarli
    Dipartimento di Sanità Pubblica Veterinaria e Patologia Animale, Sezione di Patologia Generale e Anatomia Patologica, Via Tolara di Sopra 50, Faculty of Veterinary Medicine, Bologna University, 40064 Ozzano Emilia, Bologna, Italy
    Vet Immunol Immunopathol 83:53-67. 2001
    The superficial inguinal lymph nodes of 10 piglets which had died spontaneously of post-weaning multisystemic wasting syndrome (PMWS), in which the porcine circovirus type II (PCV-II) genome was revealed by PCR, were submitted to ..
  84. ncbi An experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets
    E Albina
    , Laboratoire d'Etudes et de Recherches Avicoles et Porcines, BP 53, Ploufragan, 22440, France
    J Comp Pathol 125:292-303. 2001
    Post-weaning multisystemic wasting syndrome (PMWS) is a comparatively new disease of swine, and known to occur in France since 1996. A porcine circovirus type 2 (PCV2) is found in the lesions of affected piglets...
  85. ncbi Experimental reproduction of postweaning multisystemic wasting syndrome in cesarean-derived, colostrum-deprived piglets inoculated with porcine circovirus type 2 (PCV2): investigation of quantitative PCV2 distribution and antibody responses
    Y Okuda
    Zen noh Institute of Animal Health, 7 Ohja mach, Sakura, Chiba 285 0043, Japan
    J Vet Diagn Invest 15:107-14. 2003
    ..with porcine circovirus type 2 (PCV2), originally isolated from a pig affected with postweaning multisystemic wasting syndrome (PMWS)...
  86. ncbi Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS)
    J Nielsen
    Department of Virology, Danish Veterinary Institute, Lindholm, DK 4771, Kalvehave, Denmark
    Vet Immunol Immunopathol 92:97-111. 2003
    ..PCV2-infected piglets developed clinical and pathological symptoms consistent with postweaning multisystemic wasting syndrome (PMWS) between 14 and 21 days post-inoculation (p.i.), and were characterised as PMWS-affected...
  87. ncbi Changes in peripheral blood leukocyte populations in pigs with natural postweaning multisystemic wasting syndrome (PMWS)
    J Segales
    Departament de Sanitat i Anatomia Animals, Centre de Recerca en Sanitat Animal, Universitat Autonoma de Barcelona, Bellaterra, 08193 Barcelona, Spain
    Vet Immunol Immunopathol 81:37-44. 2001
    ..study was to analyze, by flow cytometry, changes in PBMC subsets in pigs having postweaning multisystemic wasting syndrome (PMWS), a new condition associated to porcine circovirus type 2 (PCV2) infection...
  88. ncbi Alterations of plasma ghrelin levels in rats with lipopolysaccharide-induced wasting syndrome and effects of ghrelin treatment on the syndrome
    Yuji Hataya
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Endocrinology 144:5365-71. 2003
    ..These effects of ghrelin may play an important role in the pathophysiology of inflammatory wasting syndrome, in which both the somatotropic axis and energy balance are altered...
  89. ncbi Cytokine profiles of peripheral blood mononuclear cells from pigs with postweaning multisystemic wasting syndrome in response to mitogen, superantigen or recall viral antigens
    Laila Darwich
    Dept Sanitat i Anatomia Animals, Fac Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Gen Virol 84:3453-7. 2003
    ..vitro cytokine profiles of peripheral blood mononuclear cells (PBMC) from pigs with postweaning multisystemic wasting syndrome (PMWS) and healthy pigs were determined in response to recall viral antigens (porcine circovirus type 2; PCV2)..
  90. ncbi Isolation and characterization of porcine circovirus type 2 from pigs showing signs of post-weaning multisystemic wasting syndrome in The Netherlands
    G J Wellenberg
    Department of Mammalian Virology, Institute for Animal Science and Health, ID Lelystad, The Netherlands
    Vet Q 22:167-72. 2000
    Pigs with wasting syndrome were examined for macroscopic and histopathological lesions, and for porcine circovirus (PCV)...
  91. ncbi Use of a polymerase chain reaction assay and an ELISA to monitor porcine circovirus type 2 infection in pigs from farms with and without postweaning multisystemic wasting syndrome
    Marina Sibila
    Centre de Recerca en Sanitat Animal, Departament de Sanitat i d Anatomia Animals, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Am J Vet Res 65:88-92. 2004
    ..exist between viremia with porcine circovirus type 2 (PCV2) and serum antibody profiles and between detection of PCV2 in nasal cavities and viremia of pigs from farms with and without postweaning multisystemic wasting syndrome (PMWS).
  92. ncbi Apoptosis and proliferative activity in lymph node reaction in postweaning multisystemic wasting syndrome (PMWS)
    L Mandrioli
    Department of Veterinary Public Health and Animal Pathology, Section of General Pathology and Anatomic Pathology, Faculty of Veterinary Medicine, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Bologna, Italy
    Vet Immunol Immunopathol 97:25-37. 2004
    Postweaning multisystemic wasting syndrome (PMWS) affects nursery and growing pigs, and is characterized by wasting, failure to thrive, pale skin, respiratory distress, diarrhoea and sometimes jaundice...
  93. ncbi Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review
    J Segales
    Centre de Recerca en Sanitat Animal, Departament de Sanitat i d Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Spain
    Vet Q 24:109-24. 2002
    Postweaning multisystemic wasting syndrome, caused by porcine circovirus type 2 (PCV2), is a recently described clinical condition which affects nursery and growing pigs...
  94. ncbi Reproduction of postweaning multisystemic wasting syndrome (PMWS) in immunostimulated and non-immunostimulated 3-week-old piglets experimentally infected with porcine circovirus type 2 (PCV2)
    A S Ladekjaer-Mikkelsen
    Danish Veterinary Institute, Lindholm, DK 4771 Kalvehave, Denmark
    Vet Microbiol 89:97-114. 2002
    Postweaning multisystemic wasting syndrome (PMWS) in swine is causally associated with the newly recognised pathogen, porcine circovirus type 2 (PCV2)...
  95. ncbi Reproduction of postweaning multisystemic wasting syndrome in pigs experimentally inoculated with a Swedish porcine circovirus 2 isolate
    Gordon Allan
    Veterinary Sciences Division, Department of Agriculture and Rural Development, Belfast BT4 3SD, Northern Ireland, UK
    J Vet Diagn Invest 15:553-60. 2003
    In recent years, porcine circovirus type 2 (PCV2)-associated postweaning multisystemic wasting syndrome (PMWS) has been reported worldwide...
  96. ncbi Effects of the timing of the administration of Mycoplasma hyopneumoniae bacterin on the development of lesions associated with porcine circovirus type 2
    T Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Vet Rec 158:149-54. 2006
    ..05) more severe in groups 4 and 5 than in groups 2, 3, 7 and 8...
  97. pmc Postweaning mortality in Manitoba swine
    Cate E Dewey
    Department of Population Medicine, Ontario Veterinary College, University of Guelph
    Can J Vet Res 70:161-7. 2006
    A case-control study to investigate the contribution of postweaning multisystemic wasting syndrome (PMWS) and Porcine circovirus type 2 (PCV-2) to deaths among piglets of nursery age (19 to 68 d) in Manitoba indicated a significant ..
  98. ncbi Postweaning multisystemic wasting syndrome (PMWS) in pigs with particular emphasis on the causative agent, the mode of transmission, the diagnostic tools and the control measures. A review
    M K Ghebremariam
    Department of Pathobiology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands
    Vet Q 27:105-16. 2005
    Postweaning multisystemic wasting syndrome (PMWS) is a worldwide emerging disease of weaned piglets...
  99. pmc Isolation and characterization of porcine circovirus type-2 from sera of stillborn fetuses
    MacDonald W Farnham
    Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Avenue, St Paul, Minnesota 55108, USA
    Can J Vet Res 67:108-13. 2003
    ..2 of PCV2 from 2 of these isolates were compared to PCV2 isolates from cases of post-weaning multi-systemic wasting syndrome (PMWS)...
  100. ncbi [Spread of post-weaning multisystemic wasting disease (PMWS) in Europe]
    G J Wellenberg
    Animal Health Service GD, Arnsbergstraat 7, P O Box 9, 7400AA, Deventer, The Netherlands
    Tijdschr Diergeneeskd 131:195-7. 2006
  101. ncbi PCR detection of porcine circovirus type 2 (PCV2) DNA in blood, tonsillar and faecal swabs from experimentally infected pigs
    A Caprioli
    Department of Veterinary Public Health and Animal Pathology, Faculty of Veterinary Medicine, Bologna University, Via Tolara di Sopra 50, 40064 Ozzano dell Emilia, BO, Italy
    Res Vet Sci 81:287-92. 2006
    PCV2 infection is now recognized as the major factor in the development of post-weaning multisystemic wasting syndrome (PMWS)...

Research Grants62

  1. Signaling Mechanisms of TCDD-induced AHR Activation
    Ying Xia; Fiscal Year: 2007
    ..toxic effects in animals and humans, including immune, reproductive and developmental toxicity, cancer, wasting syndrome and death...
  2. Inflammatory Cytokine regulation of POMC and Orexin neurons in cachexia.
    AARON GROSSBERG; Fiscal Year: 2012
    ..Cachexia, a wasting syndrome common to the late stages of many chronic diseases, severely limits a patient's ability to fight their ..
  3. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..and vomiting associated with chemotherapy and for appetite stimulation in AIDS patients suffering from the wasting syndrome. Other therapeutic possibilities include pain management (chronic pain), glaucoma (lowering the intraocular ..
  4. Molecular Mechanisms by which TNFalpha Modulates Fibrosis
    David A Brenner; Fiscal Year: 2013
    ..mediators, and cell death and plays a major role in the pathophysiology of shock, inflammation, and the wasting syndrome. The initial period of this grant focused on the role of TNF? in inhibiting Type I collagen gene expression ..
  5. THC impairment of CD4/CD8 T cell-mediated host resistance to HIV and influenza
    Norbert E Kaminski; Fiscal Year: 2013
    ..Moreover, HIV and cancer patients are well known users of cannabis for stimulating appetite to alleviate the wasting syndrome that accompanies AIDS and as an antiemetic to relieve the nausea produced by cancer chemotherapy...
  6. PQ6 MECHANISMS OF CACHEXIA LIKE WASTING IN A DROSPHILA CANCER MODEL
    David Bilder; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cancer cachexia, a wasting syndrome characterized by the dramatic loss of skeletal muscle and adipose tissue, is perhaps the most poorly understood feature of cancer pathophysiology...
  7. A comparative approach to evaluate muscle growth in an indeterminate growth model
    Peggy R Biga; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Project Summary Muscle wasting syndrome and cachexia are associated with many degenerative diseases, like cancer, AIDS, and other systemic diseases...
  8. DIOXINS AND HYPOTHALAMIC APPETITE NEUROPEPTIDES
    GEORGE GREELEY; Fiscal Year: 2000
    ..an exceedingly potent anorexic and leptogenic agent; a hallmark of PCAH exposure in animal studies is the " wasting syndrome" which includes depressed growth rates and hypophagia...
  9. Molecular Determinants of Virulence Porcine Circovirus 2
    Steven Krakowka; Fiscal Year: 2004
    ..with porcine circovirus type 2 (PCV-2), which can result in progression to fatal postweaning multisystemic wasting syndrome (PMWS) in swine...
  10. Analysis of anti-growth properties of processed Follistatin proteins
    THEODOR HAERRY; Fiscal Year: 2007
    ..In mice, the loss of Inhibin-a results in gonadal and adrenal tumors followed by a cancer cachexia-like wasting syndrome. These mice exhibit more than tenfold elevated levels of Activin in the blood suggesting that it may cause or ..
  11. NUTRITION INTERVENTION IN AIDS WASTING
    Sherwood Gorbach; Fiscal Year: 1999
    DESCRIPTION (adapted from the Abstract): The wasting syndrome, defined as weight loss of 10 percent or more, is a devastating complication of AIDS...
  12. SHORT TERM EFFECTS OF CANNABIONOIDS IN HIV PATIENTS
    Donald Abrams; Fiscal Year: 2000
    ..They will also summarize the short-term effects of smoked marijuana on variables associated with HIV-1 wasting syndrome by measuring changes over 21 days or use in endocrine function, appetite, energy intake, body composition and ..
  13. RETROVIRUS ASSOCIATED INTESTINAL DYSFUNCTION
    Lawrence Mathes; Fiscal Year: 1990
    The overall objective of this proposal is to characterize the retrovirus associated wasting syndrome which occurs in feline leukemia virus infected cats...
  14. SECONDARY ILLNESS AND THE WASTING OF AIDS
    Carl Grunfeld; Fiscal Year: 1999
    DESCRIPTION: The wasting syndrome in AIDS is increasing in prevalence and leading to considerable morbidity and contributing to mortality. Wasting in AIDS was initially thought to be an inevitable consequence of HIV infection...
  15. NEUROMUSCULAR DISORDERS IN HIV INFECTION AND ROLE OF AZT
    David Simpson; Fiscal Year: 1993
    ..In some patients this myopathy underlies HIV wasting syndrome. Several investigators have noted that AZT therapy may cause myopathy, prompting clinicians to halt this ..
  16. MOLECULAR REGULATION OF IGF BINDING PROTEIN 1
    Terry Unterman; Fiscal Year: 2003
    ..disorders where anabolism is impaired, including poorly controlled diabetes mellitus, renal failure, the AIDS wasting syndrome and human aging...
  17. NUTRITION, GASTROINTESTINAL DYSFUNCTION AND AIDS
    Rowan Chlebowski; Fiscal Year: 1992
    ..status and its relationship to gastrointestinal function in determining clinical outcome for the AIDS patient population, and evaluate several strategies for treating patients with AIDS at risk for development of the wasting syndrome.
  18. AIDS ENTEROPATHY
    John Bartlett; Fiscal Year: 1990
    ..Patients who have the "diarrhea wasting syndrome" will undergo microbiological studies using selective techniques based on our prior work...
  19. Smad3 as an inhibitor of atherogenesis
    Mukesh Jain; Fiscal Year: 2004
    ..for this role is derived from the fact that mice deficient in this factor succumb to a systemic inflammatory wasting syndrome. TGFb1 is expressed in human atherosclerotic lesions and its levels correlate inversely with the severity of ..
  20. AIDS-ASSOCIATED DIARRHEA AND WASTING SYNDROME IN AFRICA
    Gerald Keusch; Fiscal Year: 1991
    This proposal describes a Program-Project grant designed to investigate AIDS-associated diarrhea and wasting syndrome. There are five research projects, which will be supported by five cores...
  21. ROLE OF MYOSTATIN IN CACHEXIA
    Se Jin Lee; Fiscal Year: 2005
    ..We have also shown that overexpression of myostatin in nude mice induces a wasting syndrome that resembles the cachectic state often seen in human patients with chronic diseases such as cancer or AIDS...
  22. Proteomics and the dioxin signaling network
    JOHN LAPRES; Fiscal Year: 2003
    ..Its toxic effects include porphyria, a severe wasting syndrome, metaplasia, teratogenesis and immune suppression...
  23. ENDOCRINE ASPECTS OF MUSCLE WASTING IN AIDS
    STEPHEN MAX; Fiscal Year: 1991
    ..blockade of glucocorticoid receptors might prevent or alleviate a significant component of the wasting syndrome. The proposed studies will employ muscle biopsy specimens from human AIDS patients, as well as mice with a ..
  24. BODY PROTEIN METABOLISM AND NUTRITION IN AIDS-WASTING
    John Rathmacher; Fiscal Year: 2000
    ..Loss of lean body mass (LBM) is the earliest manifestation of the wasting syndrome seen in AIDS patients...
  25. Molecular Determinants of Virulence Porcine Circovirus 2
    Steven Krakowka; Fiscal Year: 2007
    ..with porcine circovirus type 2 (PCV-2), which can result in progression to fatal postweaning multisystemic wasting syndrome (PMWS) in swine...
  26. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  27. MECHANISM OF ESTROGENICITY OF DDT ANALOGS IN MCG-7 CELLS
    Fumio Matsumura; Fiscal Year: 2001
    ..The PI finally will address the fundamental question of whether c-Neu activation serves as a major gateway in addition to the estrogen receptor for xenobiotics to cause truly estrogenic cellular responses or not. ..
  28. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Muscle-Specific Nutritional Adaptations to Catabolic States
    S Russ Price; Fiscal Year: 2010
    ..New information regarding the mechanisms of muscle atrophy may identify therapeutic targets to reduce morbidity and mortality of chronically ill patients and improve their quality of life. ..
  30. Signaling Mechanisms Regulation Muscle Protein Turnover
    S Price; Fiscal Year: 2005
    ..Lastly, we will study adrenalectomized rats to determine if glucocorticoids can be linked to inhibition of SGK activity or activation of the MEK/ERK MAPK pathway in skeletal muscle. ..
  31. METABOLIC EFFECTS OF PROTEASE INHIBITORS IN HIV DISEASE
    Kathleen Mulligan; Fiscal Year: 2002
    ....
  32. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  33. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  34. Inositol defects and neuronal death in the weeble mouse
    Arne Nystuen; Fiscal Year: 2004
    ..Together these aims will provide an understanding of precisely where, when and why neurons are lost due to the loss of Inpp4a function. ..
  35. CREATION OF THE AD02 MOUSE
    MICHAEL ECONS; Fiscal Year: 2008
    ..This proposal focuses on the creation of an ADO2 mouse model. This animal model will allow us to test potential therapies and find genes that control disease severity. [unreadable] [unreadable] [unreadable]..
  36. Neuropeptide Y for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2003
    ..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..
  37. Cannabinoid effects on HIV/AIDS
    Patricia E Molina; Fiscal Year: 2010
    ....
  38. Consequences and Treatment of Growth Hormone Deficiency in the Metabolic Syndrome
    STEVEN KYLE GRINSPOON; Fiscal Year: 2010
    ..Lay Description: This grant will study how commonly low GH level are seen and contribute to increased cardiac risk in patients with abdominal fat and whether increasing low GH levels will improve cardiac risk in this population. ..
  39. Incarceration and HIV-Infected Inmates
    David A Wohl; Fiscal Year: 2010
    ..Aim 2. Determine the inmate, nurse-counselor and facility characteristics associated with agreeing to HIV VCT. Aim 3. Explore the risks associated with receiving an HIV diagnosis in prison. ..
  40. GENETIC AND CLINICAL STUDIES OF AD02
    MICHAEL ECONS; Fiscal Year: 2005
    ..Identification of the ADO2 gene(s) will provide substantial insight into the pathogenesis of ADO2 and to the basic biology of osteoclast function and regulation. ..
  41. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  42. SUBSTANCE P, NO & MICROGLIA IN CNS INFLAMMATION
    Barnett Nathan; Fiscal Year: 2003
    ..SP and NO modulate their effects in CNS inflammation via these cells. Hypothesis 4: The ultimate site for the effects of SP and NO may be the mitochondrial respiratory chain enzymes of these phagocytic cells. ..
  43. BLOOD COAGULATION HOMESTASIS: REGULATION OF TFPI
    Alan Schwartz; Fiscal Year: 2003
    ..These studies will thus provide a basis for elucidating the molecular mechanisms by which blood coagulation proteins are endogenously regulated. ..
  44. GROWTH RETARDATION IN CHRONIC RENAL FAILURE
    Robert Mak; Fiscal Year: 2001
    ....
  45. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. [unreadable] [unreadable] [unreadable]..
  46. Mentored Patient-Oriented Research Career Development Aw
    Lisa Kosmiski; Fiscal Year: 2004
    ..The loss of peripheral fat stores offer a unique opportunity to determine the genes involved in regulating adipose tissue mass and distribution in general. ..
  47. The effects of HIV-1 proteins on adipocyte biology
    Lisa Kosmiski; Fiscal Year: 2005
    ..These novel studies should provide further insight into the pathogenesis of the body fat changes associated with the HIV lipodystrophy syndrome. ..
  48. Validation of Medicare Claims to Define Chemotherapy Use
    Deborah Schrag; Fiscal Year: 2005
    ..This knowledge has the potential to lay the groundwork for development of an inexpensive and efficient system for monitoring and improving the quality of US cancer care. ..
  49. Is Tissue ACE Required for Diabetic Renal Damage?
    Harold Franch; Fiscal Year: 2005
    ..We believe that this approach will not only critically test our hypothesis, but will also lay the ground work for future studies into the role of ACE in the diabetic kidney. ..
  50. Mechanisms and Therapeutics in Cancer Anorexia/Cachexia
    Aminah Jatoi; Fiscal Year: 2004
    ..This K23 grant application will serve as a springboard to allow her to delve into the pathophysiology of this syndrome and to develop into an independent clinical investigator. ..
  51. The Prevalence, Pathogenesis And Therapy of HIVAN
    Jonathan Winston; Fiscal Year: 2006
    ..The award is structured to allow me to intensify my efforts in clinical research, develop new research skills through postgraduate work, and mentor trainees in clinical epidemiology, clinical trials and outcomes research. ..
  52. MALNUTRITION IN DIALYSIS PATIENTS
    TALAT IKIZLER; Fiscal Year: 2006
    ..abstract_text> ..
  53. MECHANISMS AND STRATEGIES FOR INSULIN RESISTANCE IN AIDS
    Steven Grinspoon; Fiscal Year: 2004
    ..The proposed studies represent a significant collaborative effort between clinical researchers, adipocyte biologists, epidemiologists and nutritional biochemists in satisfaction of the mandate of the RFA. ..
  54. Creatine: Is It a Body Builder for Cancer Patients?
    Aminah Jatoi; Fiscal Year: 2004
    ..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
  55. Images of a Healthy Worksite
    Isabel Fernandez; Fiscal Year: 2007
    ..The strategies and tools developed will have a potential impact on 20,000 employees in the Rochester, NY area and 60,000 worldwide. ..
  56. Chronic Alcohol & AIDS Impact on Muscle Wasting
    Patricia Molina; Fiscal Year: 2006
    ..The AIDS wasting syndrome and the resulting decline in body cell mass remains a major cause of morbidity and mortality, despite the ..
  57. PORCINE MODELS OF CORONARY ARTERY DISEASE IN DIABETES
    Michael Sturek; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. HIV+ Prison Releases to Access to HIV Care and Services
    David Wohl; Fiscal Year: 2007
    ..2. BCM will reduce intimate and drug related HIV transmission risk behaviors during the year following prison release. ..
  59. CELL-SELECTIVE EXPRESSION OF FIBROTIC GENE PATHWAYS
    Nestor Gonzalez Cadavid; Fiscal Year: 2008
    ..We expect that our studies would lead to the detection of novel targets of antifibrotic therapy for penile and vascular diseases of considerable public health impact. [unreadable] [unreadable] [unreadable]..
  60. Androgen Effects in HIV-Infected Women
    Steven Grinspoon; Fiscal Year: 2007
    ..The studies outlined in this renewal constitute an important investigative initiative of a targeted, gender-specific therapy in this largely understudied population. ..
  61. NUTRITIONAL STATUS OF HIV INFECTED INJECTION DRUG USERS
    Alice Tang; Fiscal Year: 2002
    ..The results from this observational study may help to guide the design of more effective interventions of antioxidant supplementation in the era of PI's. ..