Genomes and Genes
Summary: An abnormally decreased level of phosphates in the blood. The manifestations include hemolysis, lassitude, weakness, and convulsions. It may be found in hyperparathyroidism, rickets, osteomalacia, and several renal tubular abnormalities. (Dorland, 27th ed)
Publications276 found, 100 shown here
- Refeeding syndrome or refeeding hypophosphatemia: a systematic review of casesAnnalynn Skipper
Annalynn Skipper, PO Box 45, Oak Park, IL 60303, USA
Nutr Clin Pract 27:34-40. 2012..Theoretical descriptions of refeeding syndrome include a complex and extensive list of changes, such as hypophosphatemia, hypomagnesemia, hypokalemia, hyponatremia, hypocalcemia, hyperglycemia, and vitamin deficiency--all of which ..
- Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancyFrank Rutsch
Department of General Pediatrics, University Children s Hospital, Munster, Germany
Circ Cardiovasc Genet 1:133-40. 2008..A phosphate-poor diet markedly increases survival of NPP1 null mice, a model of generalized arterial calcification of infancy...
- Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formationRegina Goetz
Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 107:407-12. 2010..We propose that peptides derived from the C-terminal tail of FGF23 or peptidomimetics and small-molecule organomimetics of the C-terminal tail can be used as therapeutics to treat renal phosphate wasting...
- Magnesium and phosphorusJ R Weisinger
Department of Medicine, Universidad Central de Venezuela, Hospital Universitario de Caracas
Lancet 352:391-6. 1998..The need to measure Mg2+ and P routinely and to define better the real abnormal values is stressed. Correction of the abnormalities must be early in the course of the alterations...
- Hypophosphatemia: the common denominator of all ricketsDov Tiosano
Meyer Children s Hospital, Rambam Medical Center, POB 9602, 31096, Haifa, Israel
J Bone Miner Metab 27:392-401. 2009Rickets is a disease of the hypertrophic chondrocytes in the growth plate and is caused by hypophosphatemia-a derived defect in terminal chondrocyte apoptosis...
- Serum FGF23 levels in normal and disordered phosphorus homeostasisThomas J Weber
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Bone Miner Res 18:1227-34. 2003..to find a statistically significant increase, FGF23 levels were significantly correlated with the degree of hypophosphatemia in XLH...
- Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporterDominique Prie
Service de Physiologie Explorations Fonctionnelles, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
N Engl J Med 347:983-91. 2002..We hypothesized that mutations in the gene coding for the main renal sodium-phosphate cotransporter (NPT2a) may be present in patients with these disorders...
- Life-threatening refeeding syndrome in a severely malnourished anorexia nervosa patientY L Huang
Department of Psychiatry, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan
J Formos Med Assoc 100:343-6. 2001..39 mmol/L (4.3 mg/dL) to 0.19 mmol/L (0.6 mg/dL) on Day 4 of refeeding. Concurrent with the development of hypophosphatemia, she became drowsy and developed generalized muscle weakness, impaired myocardial contractility, ..
- Clenbuterol ingestion causing prolonged tachycardia, hypokalemia, and hypophosphatemia with confirmation by quantitative levelsR J Hoffman
New York City Poison Control Center, New York 10016, USA
J Toxicol Clin Toxicol 39:339-44. 2001..Acute clenbuterol toxicity resembles that of other beta2-adrenergic agonists. Most previously reported cases of clenbuterol toxicity describe patients who ate livestock illicitly treated with clenbuterol...
- Death resulting from overzealous total parenteral nutrition: the refeeding syndrome revisitedSarah J Miller
University of Montana, Department of Pharmacy Practice, Missoula, MT 59812, USA
Nutr Clin Pract 23:166-71. 2008..One of the hallmarks of the syndrome is hypophosphatemia. Since 1981, dosing schemes for addressing hypophosphatemia have been refined...
- Hypophosphatemia during continuous hemodialysis is associated with prolonged respiratory failure in patients with acute kidney injurySevag Demirjian
Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, USA
Nephrol Dial Transplant 26:3508-14. 2011b>Hypophosphatemia is common in critically ill patients and has been associated with generalized muscle weakness, ventilatory failure and myocardial dysfunction...
- Hypophosphatemia in small for gestational age extremely low birth weight infants receiving parenteral nutrition in the first week after birthGo Ichikawa
Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan
J Pediatr Endocrinol Metab 25:317-21. 2012To investigate the risk of hypophosphatemia and hypercalcemia in small for gestational age (SGA) extremely low birth weight infants (ELBWI) receiving parenteral nutrition.
- Approach to treatment of hypophosphatemiaArnold J Felsenfeld
Departments of Medicine, VA Greater Los Angeles Healthcare System, CA, USA
Am J Kidney Dis 60:655-61. 2012b>Hypophosphatemia can be acute or chronic. Acute hypophosphatemia with phosphate depletion is common in the hospital setting and results in significant morbidity and mortality...
- Does aggressive refeeding in hospitalized adolescents with anorexia nervosa result in increased hypophosphatemia?Melissa Whitelaw
Department of Nutrition and Food Services, Royal Children s Hospital, Victoria, Australia
J Adolesc Health 46:577-82. 2010..Compared to other programs, we aggressively refed hospitalized adolescents. We sought to determine the incidence of hypophosphatemia (HP) in 12-18-year-old inpatients in order to inform nutritional guidelines in this group.
- Hypophosphatemia in critically ill patientsSatoshi Suzuki
Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
J Crit Care 28:536.e9-19. 2013..The aim of this study was to assess the association of phosphate concentration with key clinical outcomes in a heterogeneous cohort of critically ill patients...
- Recent advances in renal phosphate handlingEmily G Farrow
Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202, USA
Nat Rev Nephrol 6:207-17. 2010..The identification of genetic alterations in Mendelian disorders of hypophosphatemia and hyperphosphatemia has led to the isolation of novel genes and the identification of new roles for ..
- Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouseR A Meyer
Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina 28232 2861, USA
Genomics 48:289-95. 1998Gy, along with Hyp, is a dominant mutation of the normal gene Pex causing X-linked hypophosphatemia in the mouse...
- Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalaciaT Shimada
Pharmaceutical Research Laboratory, Nephrology, Kirin Brewery Co Ltd, 3 Miyahara, Takasaki, Gunma 370 1295, Japan
Proc Natl Acad Sci U S A 98:6500-5. 2001Tumor-induced osteomalacia (TIO) is one of the paraneoplastic diseases characterized by hypophosphatemia caused by renal phosphate wasting...
- Refeeding syndrome and hypophosphatemiaMark A Marinella
Wright State University School of Medicine, Dayton, OH, USA
J Intensive Care Med 20:155-9. 2005b>Hypophosphatemia is a potentially life-threatening complication of reinstating nutrition in a malnourished patient...
- Hypophosphatemia induced by intravenous administration of saccharated ferric oxide: another form of FGF23-related hypophosphatemiaYuichiro Shimizu
Division of Nephrology and Endocrinology, Department of Medicine, The University of Tokyo Hospital, Tokyo, Japan
Bone 45:814-6. 2009..These diseases are characterized by hypophosphatemia associated with impaired proximal tubular phosphate reabsorption and inappropriately low serum 1,25-..
- FGF23 elevation and hypophosphatemia after intravenous iron polymaltose: a prospective studyBelinda J Schouten
Department of Endocrinology, Christchurch Hospital, Christchurch, New Zealand
J Clin Endocrinol Metab 94:2332-7. 2009Parenteral iron administration has been associated with hypophosphatemia. Fibroblast growth factor 23 (FGF23) has a physiological role in phosphate homeostasis via suppression of 25-hydroxyvitamin D [25(OH)D] activation and promotion of ..
- FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1Jyothsna Gattineni
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
Am J Physiol Renal Physiol 297:F282-91. 2009..Administration of FGF23 to FGFR3(-/-) mice induced hypophosphatemia in these mice (8.0 +/- 0.4 vs. 5.4 +/- 0.3 mg/dl; p < or = 0...
- Phosphate-containing dialysis solution prevents hypophosphatemia during continuous renal replacement therapyM Broman
Department of Anaesthesiology and Intensive Care, Lund University Hospital, Lund, Sweden Gambro Lundia AB, Lund, Sweden
Acta Anaesthesiol Scand 55:39-45. 2011b>hypophosphatemia occurs in up to 80% of the patients during continuous renal replacement therapy (CRRT)...
- FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasisTakashi Shimada
Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, Takasaki, Gumma, Japan
J Bone Miner Res 19:429-35. 2004..in serum 1,25-dihydroxyvitamin D by altering the expressions of key enzymes for the vitamin D metabolism followed by hypophosphatemia. This study indicates that FGF-23 is a potent regulator of the vitamin D and phosphate metabolism.
- The refeeding syndrome and glucose loadGraeme O'Connor
Division of Nutrition and Dietetics, Great Ormond Street Children s Hospital, London, United Kingdom
Int J Eat Disord 44:182-5. 2011....
- Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemiaAi Luen Wu
Department of Molecular Biology, Genentech, Inc, South San Francisco, California, United States of America
PLoS ONE 8:e57322. 2013..ectopic FGFR activation is implicated in genetic conditions associated with FGF23 overproduction and hypophosphatemia. The identity of FGFRs that mediate the activity of FGF23 or that regulate skeletal FGF23 secretion remains ..
- Biochemical effects of phosphate-containing replacement fluid for continuous venovenous hemofiltrationHorng Ruey Chua
Department of Intensive Care, Austin Health, Melbourne, Vic, Australia
Blood Purif 34:306-12. 2012..To examine biochemical effects of phosphate-containing replacement fluid (Phoxilium(®)) for continuous venovenous hemofiltration (CVVH)...
- Long-term clinical outcome and carrier phenotype in autosomal recessive hypophosphatemia caused by a novel DMP1 mutationOuti Makitie
Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
J Bone Miner Res 25:2165-74. 2010..a noncollagenous bone matrix protein expressed in osteoblasts and osteocytes, cause autosomal recessive hypophosphatemia (ARHP)...
- Predisposing chronic diseases and hypophosphatemia in patients with influenzaLena M Håglin
Department of Public Health and Clinical Medicine, Family Medicine, University Hospital of Northern Sweden, Umea, Sweden
Arch Gerontol Geriatr 51:26-30. 2010..b>Hypophosphatemia could be the explanation for reduced chemo-taxis and phagocytosis, which in addition to respiratory function ..
- Phosphate addition to hemodiafiltration solutions during continuous renal replacement therapyStephan Troyanov
Division of Nephrology and Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, 5415 de l Assomption, Montreal, Quebec, Canada
Intensive Care Med 30:1662-5. 2004b>Hypophosphatemia often occurs during continuous renal replacement therapy (CRRT)...
- Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient miceDespina Sitara
Department of Oral and Developmental Biology, The Forsyth Institute, Harvard School of Dental Medicine, 140 The Fenway, Boston, MA, 02115, USA
Matrix Biol 23:421-32. 2004..in patients with different phosphate-wasting disorders such as oncogenic osteomalacia (OOM) and X-linked hypophosphatemia (XLH), it is not yet clear whether FGF-23 is directly responsible for the abnormal regulation of mineral ion ..
- Fibroblast growth factor 23 is increased in calcium nephrolithiasis with hypophosphatemia and renal phosphate leakDomenico Rendina
Department of Clinical and Experimental Medicine, Universita Federico II, Via S Pansini, 5 80131 Naples, Italy
J Clin Endocrinol Metab 91:959-63. 2006..A significant percentage of patients with calcium nephrolithiasis and normal parathyroid function show hypophosphatemia and reduced renal phosphate reabsorption (i.e. a renal phosphate leak).
- Regulation of fibroblastic growth factor 23 expression but not degradation by PHEXShiguang Liu
Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:37419-26. 2003Inactivating mutations of Phex cause X-linked hypophosphatemia (XLH) by increasing levels of a circulating phosphaturic factor. FGF23 is a candidate for this phosphaturic factor...
- Refeeding syndrome: treatment considerations based on collective analysis of literature case reportsAkwasi Afriyie Boateng
Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, Upstate Medical University, State University of New York, Syracuse, NY 13210, USA
Nutrition 26:156-67. 2010..state in response to the nutritional load, symptoms result from fluid and electrolyte imbalances, with hypophosphatemia playing a central role...
- Abnormal regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase activity in X-linked hypophosphatemia: a translational or post-translational defectIkuma Fujiwara
Department of Pediatrics, Tohoku University, Sendai, Japan
J Bone Miner Res 18:434-42. 2003....
- Treatment of hypophosphatemia in the intensive care unit: a reviewDaniël A Geerse
Department of Intensive Care Medicine, Catharina Hospital Eindhoven, Michelangelolaan 2, Eindhoven 5623 EJ, The Netherlands
Crit Care 14:R147. 2010Currently no evidence-based guideline exists for the approach to hypophosphatemia in critically ill patients.
- Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemiaYoung H Lim
Department of Dermatology
Hum Mol Genet 23:397-407. 2014..in bone, the endogenous source of FGF23, provides the first evidence that elevated serum FGF23 levels, hypophosphatemia and osteomalacia are associated with pathologic Ras activation and may provide insight in the heretofore ..
- Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytesYves Sabbagh
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 102:9637-42. 2005..in the VDR-null mice prevents rachitic changes suggests that rickets is secondary to hypocalcemia, hypophosphatemia, or hyperparathyroidism, rather than impaired VDR action...
- Hypomagnesemia in adolescents with eating disorders hospitalized for medical instabilityKristin S Raj
Stanford University School of Medicine, Palo Alto, California, USA
Nutr Clin Pract 27:689-94. 2012..Hypomagnesemia in patients with eating disorders is poorly characterized, particularly among adolescents...
- Hypophosphatemia during nutritional rehabilitation in anorexia nervosa: implications for refeeding and monitoringRollyn M Ornstein
Division of Adolescent Medicine, Department of Pediatrics, Schneider Children s Hospital of the North Shore Long Island Jewish Health System, New Hyde Park, New York 11040, USA
J Adolesc Health 32:83-8. 2003To determine the incidence of hypophosphatemia in adolescents with anorexia nervosa (AN) hospitalized for nutritional rehabilitation and to examine factors predisposing to its development.
- Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransportersIchiro Kaneko
Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho 3, Tokushima, Japan
Pflugers Arch 461:77-90. 2011..Weanling VDR (-/-) mice had hypophosphatemia and hyperphosphaturia...
- Elevated fibroblast growth factor 23 in a patient with metastatic prostate cancer and hypophosphatemiaCasey L Cotant
Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48103, USA
Am J Kidney Dis 50:1033-6. 2007
- Factors contributing to the development of hypophosphataemia when refeeding using parenteral nutritionVanessa A Marvin
Pharmacy Department, Royal Surrey County Hospital, Guildford, Surrey GU2 7XX, UK
Pharm World Sci 30:329-35. 2008..To identify individual attributes or risk factors which predispose to the development of refeeding hypophosphataemia in patients on parenteral nutrition (PN)...
- August 2003: 47-year-old female with a 7-year history of osteomalacia and hypophosphatemiaJorge S Reis-Filho
Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Portugal
Brain Pathol 14:111-2, 115. 2004..Past medical and family history was unremarkable. Laboratory investigation disclosed hypophosphatemia, phosphaturia, elevated serum alkaline phosphatase activity, and normal serum calcium levels...
- High iFGF23 level despite hypophosphatemia is one of the clinical indicators to make diagnosis of XLHJunko Miyamoto Igaki
Division of Endocrinology and Metabolism, Tokyo Metropolitan Children s Hospital, Japan
Endocr J 58:647-55. 2011..iFGF23 were above the reference range in 19 of 21 PtPHEX (40 to 4710 pg/mL). iFGF23 did not correlate with any index of severity of XLH. Relatively high iFGF23 despite hypophosphatemia is one of the clinical indicators to diagnose XLH.
- Severe refeeding hypophosphatemia in a CAPD patient: a case reportKang Kuei Lin
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Ren Fail 28:515-7. 2006..b>Hypophosphatemia is its predominant concern, though its occurrence is unusual in uremic patients due to the concomitant ..
- Management of hypophosphatemia in nocturnal hemodialysis with phosphate-containing enema: a technical studyWinnie S Su
Division of Nephrology, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
Hemodial Int 15:219-25. 2011b>Hypophosphatemia is observed in patients undergoing nocturnal hemodialysis. Phosphate is commonly added to the dialysate acid bath, but systematic evaluation of the safety and reliability of this strategy is lacking...
- The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndromeTakehisa Yamamoto
Department of Pediatrics, Minoh City Hospital, 5 7 1 Kayano, Minoh 562 8562, Japan
J Bone Miner Metab 23:231-7. 2005McCune-Albright syndrome (MAS) is sometimes complicated by hypophosphatemia and abnormally low levels of 1,25(OH)(2)D in the presence of hypophosphatemia...
- Mechanisms of renal phosphate loss in liver resection-associated hypophosphatemiaOtmane Nafidi
Department of Surgery, Centre Hospitalier de l Universite de Montreal, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
Ann Surg 249:824-7. 2009To determine precisely the role of parathyroid hormone (PTH) and of phosphatonins in the genesis of posthepatectomy hypophosphatemia.
- Hepatectomy-related hypophosphatemia may predict donor liver dysfunction in live-donor liver transplantationD Yuan
Department of Liver and Vascular Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Transplant Proc 42:4548-51. 2010b>Hypophosphatemia after living-donor liver donation was recently reported to not be linked to donor morbidity...
- Engraftment-associated hypophosphatemia--the role of cytokine release and steep leukocyte rise post stem cell transplantationP Raanani
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel
Bone Marrow Transplant 27:311-7. 2001b>Hypophosphatemia associated with bone marrow transplantation has been infrequently reported. The suggested mechanism is phosphate uptake by the replicating cells. Various cytokines are associated with the development of hypophosphatemia...
- Hypophosphatemia is responsible for skeletal muscle weakness of vitamin D deficiencyLaurie Schubert
Department of Biochemistry, University of Wisconsin Madison, 53706 1544, United States
Arch Biochem Biophys 500:157-61. 2010..A significant reduction in muscle force was found when vitamin D deficiency was accompanied by hypophosphatemia. Within 2 days of correcting the hypophosphatemia, muscle strength was normalized...
- Effects of altered diet on serum levels of 1,25-dihydroxyvitamin D and parathyroid hormone in X-linked hypophosphatemic (Hyp and Gy) miceR A Meyer
Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
Bone 18:23-8. 1996X-linked hypophosphatemia is a metabolic bone disease occurring in both humans and mice. In mice, two different mutations (Hyp and Gy), occurring at separate but closely linked loci, have been proposed as models for this disease...
- Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: identification as an allele of 'Hyp'Kenji Moriyama
Department of Medicine and Clinical Science, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
J Biomed Sci 18:60. 2011..PHEX has been identified from analyses of human X-linked hypophosphatemic rickets and Hyp mutant mouse models. We here demonstrated a newly established dwarfism-like Kbus/Idr mouse line to be a novel Hyp model...
- Hypophosphatemia-mediated hypotension in transgenic mice overexpressing human FGF-23Peidang Liu
Department of Anatomy, Laboratory of Reproductive Medicine and The Research Center for Bone and Stem Cells, Nanjing Medical University, Nanjing, China
Am J Physiol Heart Circ Physiol 297:H1514-20. 2009..of the CVS and whether the effect of FGF-23 on the CVS is mediated by FGF receptors directly or indirectly by hypophosphatemia, FGF-23 transgenic mice and their wild-type littermates were fed a normal diet or a high-phosphate diet ..
- A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3Kathleen Page
Section of Endocrinology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8020, USA
Endocr Pract 14:869-74. 2008..To determine if there was a genetic contribution to our patient's unusual clinical presentation of nephrolithiasis and nonhealing stress fracture...
- Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHOLiping Xiao
Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Biol Chem 285:2834-46. 2010..In addition, immunohistochemistry demonstrated co-localization of FGF23 and HMW FGF2 protein in osteoblasts and osteocytes from Hyp mice. This study reveals a novel mechanism of regulation of the FGF23-P(i) homeostatic axis...
- DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasisBettina Lorenz-Depiereux
Institute of Human Genetics, GSF National Research Center for Environment and Health, 85764 Munich Neuherberg, Germany
Nat Genet 38:1248-50. 2006b>Hypophosphatemia is a genetically heterogeneous disease...
- PHEX expression in parathyroid gland and parathyroid hormone dysregulation in X-linked hypophosphatemiaT D Blydt-Hansen
Department of Pediatrics, McGill University, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada H3H 1P3
Pediatr Nephrol 13:607-11. 1999X-linked hypophosphatemia (XLH), a renal phosphate (Pi) wasting disorder with defective bone mineralization, is caused by mutations in the PHEX gene (a Pi-regulating gene with homology to endopeptidases on the X chromosome)...
- The refeeding syndrome and hypophosphatemiaMark A Marinella
Wright State University School of Medicine, Miami Valley Hospital, Dayton, OH 45429, USA
Nutr Rev 61:320-3. 2003The refeeding syndrome is an underappreciated entity characterized by acute electrolyte derangements--notably hypophosphatemia--that occur during nutritional repletion of patients with significant suboptimal caloric intake...
- Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemiaAkinori Osuka
Critical Care, Osaka Prefectural Senshu Critical Care Medical Center, Izumisano
Intern Med 48:1391-5. 2009..a case of diabetic ketoacidosis (DKA) and severe hypertriglyceridemia who developed cardiac arrest due to hypophosphatemia. He was diagnosed with diabetes and hyperlipidemia, indicating metabolic syndrome...
- Imatinib mesylate induces hypophosphatemia in patients with chronic myeloid leukemia in late chronic phase, and this effect is associated with responseS Osorio
Department of Hematology, Hospital de Getafe, Madrid, Spain
Am J Hematol 82:394-5. 2007..We report here that imatinib induces hypophosphatemia in a high proportion of our series of CML patients previously treated with interferon alpha, and that this ..
- Autosomal dominant hypophosphatemic rickets/osteomalacia: clinical characterization of a novel renal phosphate-wasting disorderM J Econs
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Endocrinol Metab 82:674-81. 1997..Our results have implications in the evaluation of patients who present with renal phosphate wasting as either adults or children...
- New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in miceBettina Lorenz-Depiereux
Institute of Human Genetics, GSF National Research Center, München Neuherberg, Germany
Mamm Genome 15:151-61. 2004..cause similar phenotypes in males, including shortened hind legs and tail, a shortened square trunk, hypophosphatemia, hypocalcemia, and rachitic bone disease...
- FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantationSangeeta Pande
Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
Nephron Physiol 104:p23-32. 2006..growth factor-23 (FGF-23) and FRP-4 are inhibitors of tubular phosphate reabsorption that may play a role in the hyperphosphatemia associated with chronic kidney disease (CKD) or in the hypophosphatemia associated with renal transplants.
- Hypophosphatemia and phosphate supplementation during continuous renal replacement therapy in childrenMaria José Santiago
Pediatric Intensive Care Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain
Kidney Int 75:312-6. 2009Severe hypophosphatemia can cause generalized muscle weakness, paralysis of the respiratory muscles, myocardial dysfunction, reduced peripheral vascular resistance, and encephalopathy...
- Hypophosphatemia following open heart surgery: incidence and consequencesJonathan Cohen
Department of General Intensive Care, Rabin Medical Center, Petah Tikva, Israel
Eur J Cardiothorac Surg 26:306-10. 2004Significant hypophosphatemia (SH) is common after major surgery and may be associated with considerable morbidity, including respiratory and cardiac failure...
- [A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus]Heon Ju Lee
Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea
Korean J Hepatol 14:381-6. 2008..ADV) effectively suppresses hepatitis B virus (HBV) replication but exhibits nephrotoxicity with severe hypophosphatemia when administered at a high dosage...
- Pseudoaldosteronism with increased serum cortisol associated with pneumonia, hypouricemia, hypocalcemia, and hypophosphatemiaA Onishi
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
Clin Nephrol 74:403-8. 2010..elevated levels of serum cortisol and creatinine clearance (CCr) as well as hypouricemia, hypocalcemia, and hypophosphatemia. All normalized after the recovery from pneumonia and the administration of spironolactone...
- The PHEX transgene corrects mineralization defects in 9-month-old hypophosphatemic miceAdele Boskey
Musculoskeletal Integrity Program, Hospital for Special Surgery, Weill Medical College, Cornell University, 535 East 70th Street, New York, NY 10021, USA
Calcif Tissue Int 84:126-37. 2009b>Hypophosphatemia is an X-linked dominant disorder resulting from a mutation in the PHEX gene...
- Effects of hypophosphatemia on glucose tolerance and insulin secretionF J Paula
Department of Internal Medicine, , , Brazil
Horm Metab Res 30:281-4. 1998..glucose tolerance in individuals with moderate and acute phosphate deprivation and in patients with chronic hypophosphatemia. The individuals with dietary phosphate deprivation, evidenced by a significant reduction in phosphaturia ..
- Rapamycin-induced hypophosphatemia and insulin resistance are associated with mTORC2 activation and Klotho expressionT Tataranni
Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari A Moro, Italy
Am J Transplant 11:1656-64. 2011..In conclusion, our data would suggest that rapamycin may influence phosphate homeostasis and insulin resistance modulating Klotho expression through mTORC2 activation...
- Malignant phosphaturic mesenchymal tumor, mixed connective tissue variant of the tongueNaoki Uramoto
Division of Otolaryngology, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
Auris Nasus Larynx 36:104-5. 2009..In accordance with the tumor recurrence and resection, the hypophosphatemia progressed and improved...
- Cefotetan-induced hemolytic anemia causing severe hypophosphatemiaS Mohammed
Division of Gastroenterology, Brown University, School of Medicine, Providence, Rhode Island
Am J Hematol 46:369-70. 1994..The increased uptake of phosphorus by cells during erythropoiesis can result in severe hypophosphatemia. A case of severe hypophosphatemia due to accelerated erythropoiesis in response to Cefotetan-induced ..
- Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic miceL Beck
Department of Pediatrics, McGill University Montreal Children s Hospital Research Institute, Quebec, Canada
J Clin Invest 99:1200-9. 1997..homology to endopeptidases on the X chromosome, was recently identified as the candidate gene for X-linked hypophosphatemia. In the present study, we cloned mouse and human Pex/PEX cDNAs encoding part of the 5' untranslated region, ..
- Medication-induced hypophosphatemia: a reviewG Liamis
Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
QJM 103:449-59. 2010b>Hypophosphatemia (serum phosphorus concentration <2.5 mg/dl, 0.8 mmol/l), although rare in the general population, is commonly observed in hospitalized patients and may be associated with drug therapy...
- Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndromeYi Sun Yang
Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung Shan Medical University Hospital, Chung Shan Medical University, 110 Sec 1, Chien Kuo N Road, Taichung, 402, Taiwan
Rheumatol Int 27:593-7. 2007..Conversely, in patients with Sjögren's syndrome, early investigation and treatment of renal tubular dysfunction may prevent future complications, such as osteomalacia...
- Hypophosphataemia causing profound cardiac failure after cardiac surgeryR M Heames
Shackleton Department of Anaesthesia, Southampton Hospitals NHS Trust, Southampton, UK
Anaesthesia 61:1211-3. 2006....
- Paraplegia due to ossification of ligamenta flava in X-linked hypophosphatemia. A case reportC L Vera
Medical University of South Carolina, USA
Spine (Phila Pa 1976) 22:710-5. 1997..decompression at the most prominent of multiple posterior calcified thoracic lesions in a case of X-linked hypophosphatemia was undertaken for treatment and diagnosis purposes, as well as to assess possible nature of the ..
- Hypophosphatemia: an evidence-based problem-solving approach to clinical casesFarahnak Assadi
Section of Pediatric Nephrology, Rush University Medical Center, Chicago, Illinois 60611, USA
Iran J Kidney Dis 4:195-201. 2010b>Hypophosphatemia is defined as a serum phosphate level of less than 2.5 mg/dL (0.8 mmol/L)...
- Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse modelTeruyo Nakatani
Department of Oral Medicine, Harvard School of Dental Medicine, Room 304, 188 Longwood Ave, Boston, MA 02115, USA
FASEB J 23:3702-11. 2009..The mutation is associated with severe hypophosphatemia due to excessive urinary phosphate wasting...
- Hyponatremia, hypophosphatemia, and hypouricemia in a girl with macrophage activation syndromeKazuki Yamazawa
Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Pediatrics 118:2557-60. 2006..macrophage activation syndrome complicating systemic-onset juvenile arthritis who developed hyponatremia, hypophosphatemia, and hypouricemia associated with a high level of serum tumor necrosis factor alpha...
- Hypophosphatemia: diagnostic significance in Legionnaires' diseaseBurke A Cunha
Am J Med 119:e5-6. 2006
- Hepatic surgery-related hypophosphatemiaHarish K Datta
Department of Clinical Biochemistry and Metabolism, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
Clin Chim Acta 380:13-23. 2007This review describes pathophysiology of post-surgical hypophosphatemia (HP), which has particularly high incidence following liver transplantation...
- Electrolytic disorders, hyperosmolar states, and lactic acidosis in brain-dead patientsJ M Dominguez-Roldan
Department of Intensive Care, Hospital Virgen del Rocio UCI HRT, Avda Manuel Siurot s n, 41013 Seville, Spain
Transplant Proc 37:1987-9. 2005..Our results also suggest that the inclusion in the monitoring protocol of anerobic metabolism data including lactate levels can help to avoid occult ischemia of organs, and consequently improve their quality for transplantation...
- Venous sampling for fibroblast growth factor-23 confirms preoperative diagnosis of tumor-induced osteomalaciaYasuhiro Takeuchi
Division of Endocrinology and Nephrology, Department of Medicine, University of Tokyo School of Medicine, Japan
J Clin Endocrinol Metab 89:3979-82. 2004Tumor-induced osteomalacia (TIO) is a paraneoplastic disorder characterized by hypophosphatemia, phosphaturia, inappropriately low serum levels of 1,25-dihydroxyvitamin D for hypophosphatemia, and skeletal undermineralization...
- [Endocrine diseases accompanied by hypophosphatemia or hyperphosphatemia]Konosuke Nakayama
Department of Endocrinology and Diabetes, Saitama Medical University
Nihon Rinsho . 2006
- Hypophosphatemia-induced seizure in a child with diabetic ketoacidosisSimone Brasil de Oliveira Iglesias
Pediatric Intensive Care Unit, Department of Pediatrics, Federal University of Sao Paulo, SaoPaulo, Brazil
Pediatr Emerg Care 25:859-61. 2009We report an unusual case of hypophosphatemia-related seizure in a child with diabetic ketoacidosis (DKA)...
- Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotypeReinhold G Erben
Institute of Physiology, Physiological Chemistry and Animal Nutrition, Ludwig Maximilians University, Munich, Germany
J Bone Miner Res 20:1149-60. 2005....
- Hypophosphatemia in children hospitalized within an intensive care unitFernanda Souza de Menezes
Pediatric Intensive Care Unit, Hospital Sao Paulo, Sao Paulo, Brazil
J Intensive Care Med 21:235-9. 2006The aims of this study were to estimate the occurrence of hypophosphatemia and to identify potential risk factors and outcome measures associated with this disturbance in children admitted to a pediatric intensive care unit...
- Hypophosphatemia: an evidence-based approach to its clinical consequences and managementJamshid Amanzadeh
Section of Nephrology at Veterans Affairs North Texas Health Care System, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Nat Clin Pract Nephrol 2:136-48. 2006..decreased gastrointestinal absorption, and increased urinary losses, are the primary mechanisms of hypophosphatemia, which affects approximately 2% of hospitalized patients...
- [Hypophosphatemia in parenteral nutrition: prevention and associated risks factors]J M Llop Talaverón
Servicio de Farmacia Hospital Universitari de Bellvitge L Hospitalet de Llobregat Barcelona
Nutr Hosp 19:362-6. 2004To determine the incidence of hypophosphatemia in parenterally fed patients, the phosphate amount necessary to prevent this complication and associated risks factors.
- Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practiceSara Louise Day
Brighton and Sussex University Hospitals, National Health Service Trust, Brighton, Sussex, United Kingdom
J Acquir Immune Defic Syndr 38:301-4. 2005Tenofovir disoproxil fumarate (TDF) has been anecdotally associated with isolated hypophosphatemia (HP) as well as proximal tubular toxicity and renal dysfunction in which HP has consistently been a feature...
- Hypophosphatemia: an update on its etiology and treatmentAndre Gaasbeek
Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
Am J Med 118:1094-101. 2005..The incidence of hypophosphatemia in selected patient series can be more than 20%, with clinical sequelae ranging from mild to life threatening...
- Hepatic resection-related hypophosphatemia is of renal origin as manifested by isolated hyperphosphaturiaRonald R Salem
Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Ann Surg 241:343-8. 2005The objective of this study was to elucidate and define the pathophysiological mechanism(s) responsible for the clinically relevant phenomenon of posthepatic resection hypophosphatemia.
- Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'?I Bhan
Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Kidney Int 70:1486-94. 2006b>Hypophosphatemia is a common complication of kidney transplantation...
- Severe hypophosphatemia in sepsis as a mortality predictorRenana Shor
Edith Wolfson Medical Center, PO Box 5, Holon, Israel
Ann Clin Lab Sci 36:67-72. 2006b>Hypophosphatemia has long been reported to be associated with sepsis and has been correlated with sepsis severity...
- A new graduated dosing regimen for phosphorus replacement in patients receiving nutrition supportKaleb A Brown
Department of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
JPEN J Parenter Enteral Nutr 30:209-14. 2006b>Hypophosphatemia is a common metabolic complication in patients receiving specialized nutrition support...
- Central pontine myelinolysis temporally related to hypophosphataemiaA W Michell
J Neurol Neurosurg Psychiatry 74:820. 2003
- Intravenous phosphate in the intensive care unit: more aggressive repletion regimens for moderate and severe hypophosphatemiaThierry Charron
Medical and Surgical Intensive Care Units, Maisonneuve Rosemont Hospital, University of Montreal, 5415 de l Assomption, H1T 2M4, Montreal, PQ, Canada
Intensive Care Med 29:1273-8. 2003To evaluate efficacy and safety of aggressive correction of hypophosphatemia with intravenous potassium phosphate in the ICU.
- Life-threatening hypophosphatemia after right hepatic lobectomy for live donor adult liver transplantationJ J Pomposelli
Division of Hepatobiliary Surgery and Liver Transplantation, Lahey Clinic Medical Center, Burlington, MA 01805, USA
Liver Transpl 7:637-42. 2001Life-threatening hypophosphatemia (phosphorus < 1.0 mg/dL) has been reported only once after liver resection for tumor and was associated with a significant increase in postoperative complications...
- IDENTIFICATION OF NOVEL PHOSPHATE REGULATORSHARALD JUEPPNER; Fiscal Year: 2007..groups have led to the identification of key regulators, including 1) PHEX, which is mutated in X-linked hypophosphatemia (XLH), 2) FGF23, for which gain-of-function mutations were found in autosomal dominant hypophosphatemic ..
- Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin DBeate Lanske; Fiscal Year: 2010..identified molecule, and implicated in the pathogenesis of various human diseases, including in X-linked hypophosphatemia (XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor ..
- Regulation Of Inorganic Phosphorus (Pi) Metabolism By EstrogenHassane Amlal; Fiscal Year: 2013..Clinical studies have shown that women treated with E2 exhibited renal Pi wasting and hypophosphatemia. Both kidney and intestine play an important role in the control and maintenance of Pi homeostasis...
- Vitamin D and fibroblast growth factor 23 physiology in adolescent girlsDEBORAH MICHELLE MITCHELL; Fiscal Year: 2012..Several human diseases are characterized by FGF23 excess, including X-linked hypophosphatemia, autosomal dominant hypophosphatemic rickets, and tumor-induced osteomalacia...
- The Roles of FAM20C (DMP4) in Odontogenesis and OsteogenesisChunlin Qin; Fiscal Year: 2013..of Fam20C prevents cells from differentiating into mature odontogenic/osteogenic cells and leads to hypophosphatemia. The combined results of cell differentiation failure and lower serum phosphate level cause defects in the ..
- Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth &BiomechanicsMarie Demay; Fiscal Year: 2013..b>Hypophosphatemia impairs apoptosis of hypertrophic chondrocytes, both in vivo and in vitro, leading to the development of ..
- Conditional Isolation of Fgf23 ActivityKenneth E White; Fiscal Year: 2011..growth factor-23 (FGF23) as the cause of autosomal dominant hypophosphatemic rickets (ADHR), characterized by hypophosphatemia secondary to isolated renal phosphate wasting and metabolic bone disease...
- Identification and Function of nuDMP1 in Odontoblast DifferentiationYongbo Lu; Fiscal Year: 2013..autosomal recessive hypophosphatemic rickets (ARHR), characterized by hypomineralization in dentin and bone, hypophosphatemia and the elevation of circulating fibroblast growth factor 23 (FGF23) levels...
- Fibroblast Growth Factor 23 (FGF23) and It's ReceptorsJyothsna Gattineni; Fiscal Year: 2013..In humans, high FGF23 levels result in disturbances in phosphate homeostasis with hypophosphatemia and low 1,25 Vitamin D levels resulting in rickets, bone fractures and poor growth...
- Calcitonin for treating X-linked hypophosphatemiaKARL LEONARD INSOGNA; Fiscal Year: 2012DESCRIPTION (provided by applicant): The pathophysiology of X-linked hypophosphatemia (XLH) was clarified with the report in 1995 by the HYP Consortium that mutations in the neutral endopeptidase PHEX are the genetic basis for this ..
- Control of FGF23 Bioactivity via Circulating alpha-KlothoKenneth E White; Fiscal Year: 2013..cloning approach to isolate the gene for autosomal dominant hypophosphatemic rickets (ADHR), characterized by hypophosphatemia secondary to renal phosphate wasting, rickets/osteomalacia and fracture...
- Dietary and hormonal regulation of FGF-23 in humansSherri Ann M Burnett Bowie; Fiscal Year: 2010..Data from three PO4 wasting disorders (X-linked hypophosphatemia, autosomal dominant hypophosphatemic rickets, and tumor induced osteomalacia) demonstrate that fibroblast ..
- FGF2 Isoforms in Bone and Phosphate HomeostasisMARJA MARIE HURLEY; Fiscal Year: 2013..mice have increased FGF23 in serum and bone, dwarfism, decreased bone mineral density (BMD), osteomalacia, hypophosphatemia, and abnormal FGF23/FGFReceptor/ klotho/MAPK and Wnt signaling in bone and kidney...
- Etiology and Therapy of Rickets in the Hyp mouse model of XLHMarie Demay; Fiscal Year: 2013..b>Hypophosphatemia impairs apoptosis of hypertrophic chondrocytes in vivo and in vitro, leading to the development of rickets in ..
- Training in Pediatric Endocrinology and Diabetes ResearchWilliam V Tamborlane; Fiscal Year: 2012..for the Study of Hypoglycemia, the Yale Core Center for Muscular Skeletal Diseases, the Center for X-linked Hypophosphatemia, the new program in Human and Translational Immunology and, most recently, the CTSA-supported Yale Center for ..
- X-LINKED HYPOPHOSPHATEMIA: IGF-1 INHIBITORSRalph Meyer; Fiscal Year: 1990X-linked hypophosphatemia (vitamin D-resistant rickets) is caused by mutant dominant genes on the X chromosome of humans (HYP; HPDR) and mice (Hyp)...
- GENETIC LINKAGE MAPPING OF FAMILIAL BENIGN HYPERCALCEMIAHunter Heath; Fiscal Year: 1991..Affected individuals also have mild hypermagnesemia and hypophosphatemia, normal to slightly elevated plasma parathyroid hormone (PTH) levels, and usually unremarkable parathyroid ..
- Osteoblast Derived Pathogenic Factors in Hyp MiceNorimoto Yanagawa; Fiscal Year: 2005X-linked hypophosphatemia (XLH), the most common inherited form of rickets in North America, is an X-linked dominant Mendelian disorder characterized by hypophosphatemia from renal Pi wasting, abnormal vitamin D metabolism, and impaired ..
- DIABETIC KETOACIDOSIS: ALTERATIONS IN MINERAL METABOLISMJoseph Fisher; Fiscal Year: 1980b>Hypophosphatemia accompanied by a decline in red blood cell 2,3 disphosphoglyceric acid (2,3-DPG) has been known for many years to occur during the therapy of diabetic ketoacidosis (DKA)...
- Trafficking of NaPilla in brush border microvilliJudith Blaine; Fiscal Year: 2006..transplantation, AIDS, and several therapeutic drugs are well known to cause or to be associated with hypophosphatemia or hyperphosphatemia, mainly by affecting renal tubular Pi transport...
- SUPPORT FOR METABOLIC DISEASE RESEARCH CENTERAlexander Leaf; Fiscal Year: 1980..bone diseases; the inter-relationships of parathyroid hormone and vitamin D metabolites in idiopathic hypophosphatemia and their alterations during therapy; and the role of urinary oxalate and urinary gamma-carboxy-glutamic acid ..
- MITOCHONDRIAL VITAMIN D METABOLISM IN HYPOPHOSPHATEMIAThomas Carpenter; Fiscal Year: 1991..His expertise and direct oversight of the project will provide an incomparable environment for training...
- Role of Lipid Domains in Renal Phosphate TransportHubert Zajicek; Fiscal Year: 2006..transplantation, AIDS, and several therapeutic drugs are well known to cause or to be associated with hypophosphatemia or hyperphosphatemia, mainly by affecting renal tubular Pi transport...
- THE MOLECULAR BASIS OF ANTIDIURETIC HORMONE ACTIONMURRAY ETTINGER; Fiscal Year: 1980..Chemical modification and fluorescence probe approaches will be used in these studies. The response of brush border plasma membranes isolated from an animal model for X-linked hypophosphatemia to cAMP is also being examined.
- PEDIATRIC NEPHROLOGY TRAININGMichel Baum; Fiscal Year: 2005..Fellows also attend seminars in basic science departments. The research mentor, as well as the program director, closely supervise trainees to ensure that the goals of the training program are achieved. ..
- Proximal Tubule Transport Defect in Hyp MiceMichel Baum; Fiscal Year: 2007X-linked hypophosphatemia is characterized by renal phosphate wasting resulting in hypophosphatemia, and a relative deficiency of 1,25(OH)2 vitamin D...
- DISORDERS OF MINERAL METABOLISM IN CHILDRENThomas Carpenter; Fiscal Year: 2003..Furthermore, the long-standing collaborations with the Departments of Internal Medicine and Orthopaedics provide for a rich intellectual environment, and critical mass of interest. ..
- THE STRUCTURE OF CALBINDIN-D28KRajiv Kumar; Fiscal Year: 2004..These findings will potentially be of significance in the understanding of neurodegenerative disorders, cerebellar function and long-term hippocampal potentiation. ..
- REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7Rajiv Kumar; Fiscal Year: 2010..determine whether alterations in serum Pi induced by dietary changes in Pi, influence FGF 7 similarly to the hypophosphatemia in patients or animal models with renal Pi wasting...
- Hyperoxaluria and Nephrolithiasis After Gastric Bypass Surgery for ObesityRajiv Kumar; Fiscal Year: 2008..Finally, we will study why these complications occur and we will develop ways in which to prevent kidney stones and loss of kidney function after gastric bypass surgery. [unreadable] [unreadable] [unreadable]..
- Role of FGF-23 in Regulation of Phosphate HomeostasisSuzanne Jan de Beur; Fiscal Year: 2004..and autosomal dominant hypophosphatemic rickets (ADHR) are phenotypically similar disorders characterized by hypophosphatemia, decreased renal phosphate reabsorption, defective calcitriol synthesis, and defective skeletal ..
- PHOSPHOTONIN--A NOVEL PHOSPHATE REGULATORY HORMONESuzanne Jan de Beur; Fiscal Year: 2003..Oncogenic osteomalacia (OOM) is a paraneoplastic syndrome characterized by hypophosphatemia, hypophosphaturia and osteomalacia...
- EXPRESSION AND STRUCTURE OF THE CALCIUM SENSING RECEPTORRajiv Kumar; Fiscal Year: 2007..Furthermore, this information will serve as the basis for more extensive experiments involving the structure of the full-length receptor. [unreadable] [unreadable]..
- REGULATION OF OSTEOBLAST GENE EXPRESSIONMarie Demay; Fiscal Year: 2007....
- Tools for mapping transcriptional networksUri Alon; Fiscal Year: 2006..We expect that the analysis tools and concepts developed in E. coli will be very useful in mapping complex regulatory circuits in other cell types. [unreadable] [unreadable]..
- THE PHYSIOLOGY AND METABOLISM OF VITAMIN DRajiv Kumar; Fiscal Year: 2003..Results of this investigation could lead to a better understanding of the pathogenesis of bone diseases and the formulation of new therapeutic strategies in disorders such as hyperparathyroidism and osteoporosis. ..
- Biology of a Novel Phosphaturic Protein - sFRP-4Rajiv Kumar; Fiscal Year: 2007..factor, secreted frizzled-related protein-4 (sFRP-4), one of the factors responsible for the phosphaturia, hypophosphatemia and inappropriately adapted 25-hydroxyvitamin D3 1 alpha-hydroxylase (25(OH) D3 1alphaOHase) activity seen in ..
- OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICSAdele Boskey; Fiscal Year: 2003..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
- GENETIC DETERMINANTS OF METABOLIC BONE DISEASEMICHAEL ECONS; Fiscal Year: 2003..Additionally, the PI has extensive experience and success in the study of kindreds with various forms of metabolic bone disease. ..
- CADHERIN REGULATION OF OSTEOBLAST FUNCTIONRoberto Civitelli; Fiscal Year: 2004..These studies will disclose a novel mechanism by which the activity of bone forming cells is controlled invivo Alterations of cadherin mediated cell-cell interactions by hormonal imbalances or aging may lead to osteoblast failure. ..
- Micro-computed tomography system (Micro-CT)Adele Boskey; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- 2005 Bones & Teeth Gordon ConferenceRene St Arnaud; Fiscal Year: 2005..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
- MECHANISM OF HARD TISSUE MINERALIZATIONAdele L Boskey; Fiscal Year: 2010..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
- DIFFERENTIAL FUNCTION AND REGULATION OF RUNX2 ISOFORMSL Quarles; Fiscal Year: 2007..These studies will define the unique functions of the N-terminal domains, and determine if translational regulation contributes to the tissue-specific expression of Runx2-I and Runx2-II isoforms. ..
- TWO X-LINKED GENES THAT REGULATE MINERAL HOMEOSTASISMichael Whyte; Fiscal Year: 2002..Specifically, the genetic defects cause X-linked recessive idiopathic hypoparathyroidism (XHPT) and X-linked hypophosphatemia (XLH). The XHPT locus has been narrowed to a 1...
- GENETIC AND CLINICAL STUDIES OF AD02MICHAEL ECONS; Fiscal Year: 2005..Identification of the ADO2 gene(s) will provide substantial insight into the pathogenesis of ADO2 and to the basic biology of osteoclast function and regulation. ..
- Advances in Mineral Metabolism (AMM) meetingRene St Arnaud; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- A Phase 1 Study/DNA-Based Vaccine vs Prostatic Acid PaseDouglas McNeel; Fiscal Year: 2006..This trial will serve as a platform and model for clinical trial evaluation of antigens identified in the second aim of the proposal. ..
- The FIAT-ATF4 interaction and the control of bone massRene St Arnaud; Fiscal Year: 2010..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
- EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTSL Quarles; Fiscal Year: 2009..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
- Cardiovascular Disease Following Hypertensive PregnancyMyles Wolf; Fiscal Year: 2007..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. [unreadable] [unreadable]..
- Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography SystemRAMIRO TORIBIO; Fiscal Year: 2006..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
- Structure, Function and Regulation of Renal K ChannelsGary Desir; Fiscal Year: 2005..These studies should provide important information regarding the molecular structure of KCNA10 and its role in renal solute homeostasis. ..
- Medication Adherence in Adolescents with HypertensionRenee Robinson; Fiscal Year: 2005..effective assessment methods to identify risk factors for non-adherence and to improve long-term medication adherence in children and adolescents suffering from chronic renal diseases, such as hypertension or solid organ transplantation ..
- CREATION OF THE AD02 MOUSEMICHAEL ECONS; Fiscal Year: 2008..This proposal focuses on the creation of an ADO2 mouse model. This animal model will allow us to test potential therapies and find genes that control disease severity. [unreadable] [unreadable] [unreadable]..
- PTHrP on normal osteoblast differentiation and functionRAMIRO TORIBIO; Fiscal Year: 2008..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
- Genes Controlling the Renal Handling of PhosphateRalph Meyer; Fiscal Year: 2004..The most common disease in this group is X-linked hypophosphatemia, in which the renal abnormality leads to low levels of plasma phosphate that impair skeletal mineralization...
- Topical virucides to prevent oral transmissionKoen van Rompay; Fiscal Year: 2004..If topical tenofovir administration were effective, then this simple strategy would be highly affordable for developing countries. ..
- Advances in Mineral Metabolism (AIMM) annual meetingRene St Arnaud; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..