metabolic syndrome x

Summary

Summary: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)

Top Publications

  1. ncbi Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
    Scott M Grundy
    Circulation 112:2735-52. 2005
  2. ncbi Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation
    K G M M Alberti
    Department of Endocrinology and Metabolic Medicine, St Mary s Hospital, London, UK and International Diabetes Institute, Caulfield, Australia
    Diabet Med 23:469-80. 2006
  3. ncbi Inflammation and metabolic disorders
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 444:860-7. 2006
  4. ncbi The metabolic syndrome--a new worldwide definition
    K George M M Alberti
    Department of Endocrinology and Metabolism, St Marys Hospital, London W2 1NY, UK
    Lancet 366:1059-62. 2005
  5. ncbi Abdominal obesity and metabolic syndrome
    Jean Pierre Despres
    Quebec Heart Institute, Hôpital Laval Research Centre, 2725 Chemin Sainte Foy, Pavilion Marguerite D Youville, 4th Floor, Quebec City, QC G1V 4G5, Canada
    Nature 444:881-7. 2006
  6. ncbi The metabolic syndrome
    Robert H Eckel
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Lancet 365:1415-28. 2005
  7. pmc Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:1752-61. 2004
  8. ncbi Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
    Scott M Grundy
    Circulation 109:433-8. 2004
  9. ncbi The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis
    Salvatore Mottillo
    Jewish General Hospital McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 56:1113-32. 2010
  10. ncbi Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    Marc T Hamilton
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Diabetes 56:2655-67. 2007

Research Grants

Detail Information

Publications242 found, 100 shown here

  1. ncbi Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
    Scott M Grundy
    Circulation 112:2735-52. 2005
  2. ncbi Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation
    K G M M Alberti
    Department of Endocrinology and Metabolic Medicine, St Mary s Hospital, London, UK and International Diabetes Institute, Caulfield, Australia
    Diabet Med 23:469-80. 2006
    ..An additional aim was to highlight areas where more research into the MetS is needed...
  3. ncbi Inflammation and metabolic disorders
    Gokhan S Hotamisligil
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 444:860-7. 2006
    ..Collectively, these diseases constitute the greatest current threat to global human health and welfare...
  4. ncbi The metabolic syndrome--a new worldwide definition
    K George M M Alberti
    Department of Endocrinology and Metabolism, St Marys Hospital, London W2 1NY, UK
    Lancet 366:1059-62. 2005
  5. ncbi Abdominal obesity and metabolic syndrome
    Jean Pierre Despres
    Quebec Heart Institute, Hôpital Laval Research Centre, 2725 Chemin Sainte Foy, Pavilion Marguerite D Youville, 4th Floor, Quebec City, QC G1V 4G5, Canada
    Nature 444:881-7. 2006
    ..Better risk assessment algorithms are needed to quantify diabetes and cardiovascular disease risk on a global scale...
  6. ncbi The metabolic syndrome
    Robert H Eckel
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Lancet 365:1415-28. 2005
    ..The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction...
  7. pmc Increased oxidative stress in obesity and its impact on metabolic syndrome
    Shigetada Furukawa
    Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:1752-61. 2004
    ....
  8. ncbi Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
    Scott M Grundy
    Circulation 109:433-8. 2004
  9. ncbi The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis
    Salvatore Mottillo
    Jewish General Hospital McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 56:1113-32. 2010
    ....
  10. ncbi Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    Marc T Hamilton
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Diabetes 56:2655-67. 2007
    ....
  11. pmc Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 116:1784-92. 2006
    ..This Review describes the pathophysiology of adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome...
  12. ncbi Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    Earl S Ford
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
    JAMA 287:356-9. 2002
    ..Limited information is available about the prevalence of the metabolic syndrome in the United States, however...
  13. ncbi Global and societal implications of the diabetes epidemic
    P Zimmet
    International Diabetes Institute, 260 Kooyong Road, Caulfield, Victoria 3162, Australia
    Nature 414:782-7. 2001
    ..The prevention of diabetes and control of its micro- and macrovascular complications will require an integrated, international approach if we are to see significant reduction in the huge premature morbidity and mortality it causes...
  14. ncbi Metabolic syndrome pandemic
    Scott M Grundy
    Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y3 206, Dallas, TX 75390 9052, USA
    Arterioscler Thromb Vasc Biol 28:629-36. 2008
    ..On the other hand, in parts of developing world in which young adults predominate, the prevalence is lower; but with increasing affluence and aging of the population, the prevalence undoubtedly with rise...
  15. ncbi Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    Giulio Marchesini
    Unit of Metabolic Diseases and Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Hepatology 37:917-23. 2003
    ..The increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades...
  16. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  17. ncbi Obesity and the metabolic syndrome in children and adolescents
    Ram Weiss
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    N Engl J Med 350:2362-74. 2004
    ....
  18. pmc Uric acid and cardiovascular risk
    Daniel I Feig
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 359:1811-21. 2008
  19. ncbi Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies
    Apoor S Gami
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 49:403-14. 2007
    ..The purpose of this research was to assess the association between the metabolic syndrome (MetSyn) and cardiovascular events and mortality by meta-analyses of longitudinal studies...
  20. ncbi Adipose tissue, inflammation, and cardiovascular disease
    Anders H Berg
    Department of Cell Biology, Bronx, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circ Res 96:939-49. 2005
    ..The targeted suppression of various proinflammatory cascades in adipocytes specifically represents an exciting new therapeutic opportunity for the cardiovascular disease area...
  21. ncbi Waist circumference and not body mass index explains obesity-related health risk
    Ian Janssen
    Department of Community Health and Epidemiology, Queen s University, Kingston, Canada
    Am J Clin Nutr 79:379-84. 2004
    ..The addition of waist circumference (WC) to body mass index (BMI; in kg/m(2)) predicts a greater variance in health risk than does BMI alone; however, whether the reverse is true is not known...
  22. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  23. ncbi Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California Los Angeles School of Medicine, 924 Westwood Boulevard, Los Angeles, CA 90024, USA
    Am J Clin Nutr 79:820-5. 2004
    ..Although the role of vitamin D in type 2 diabetes is well recognized, its relation to glucose metabolism is not well studied...
  24. ncbi Prevalence of the metabolic syndrome and overweight among adults in China
    Dongfeng Gu
    Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Lancet 365:1398-405. 2005
    ..Little information exists on the prevalence of the metabolic syndrome in China. We aimed to provide up-to-date estimates of the prevalence of the metabolic syndrome and overweight in the general adult population in China...
  25. ncbi Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    Peter W F Wilson
    The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 112:3066-72. 2005
    ..The objective was to investigate risk for CVD, CHD, and T2DM according to metabolic syndrome traits...
  26. ncbi The metabolic syndrome
    Marc Andre Cornier
    University of Colorado Denver, Division of Endocrinology, Metabolism, and Diabetes, Mail Stop 8106, 12801 East 17 Avenue, Room 7103, Aurora, Colorado 80045, USA
    Endocr Rev 29:777-822. 2008
    ..Finally, in 2008 the MetS is an evolving concept that continues to be data driven and evidence based with revisions forthcoming...
  27. ncbi Obesity and the metabolic syndrome in developing countries
    Anoop Misra
    Department of Diabetes and Metabolic Diseases, Fortis Flt Lt Rajan Dhall Hospital, Vasant Kunj, New Delhi 110070, India
    J Clin Endocrinol Metab 93:S9-30. 2008
    ..Prevalence of obesity and the metabolic syndrome is rapidly increasing in developing countries, leading to increased morbidity and mortality due to type 2 diabetes mellitus (T2DM) and cardiovascular disease...
  28. pmc Obesity and metabolic syndrome in circadian Clock mutant mice
    Fred W Turek
    Department of Neurology, Northwestern University, Evanston, IL 60208, USA
    Science 308:1043-5. 2005
    ..These results suggest that the circadian clock gene network plays an important role in mammalian energy balance...
  29. ncbi The metabolic syndrome in children and adolescents - an IDF consensus report
    Paul Zimmet
    International Diabetes Institute, Melbourne, Victoria, Australia
    Pediatr Diabetes 8:299-306. 2007
  30. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  31. pmc Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
    Endocr Rev 30:96-116. 2009
    ..If diabetes might result from excessive intake of fructose, then simple public health measures could have a major impact on improving the overall health of our populace...
  32. pmc Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007
    Soo Lim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Diabetes Care 34:1323-8. 2011
    ....
  33. pmc Metabolic syndrome and risk of cancer: a systematic review and meta-analysis
    Katherine Esposito
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
    Diabetes Care 35:2402-11. 2012
    ..We did a systematic review and meta-analysis to assess the association between metabolic syndrome and risk of cancer at different sites...
  34. ncbi Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study
    Giorgio Bedogni
    Centro Studi Fegato, Area Science Park, Basovizza, and Department of BBCM, University of Trieste, Italy
    Hepatology 42:44-52. 2005
    ..In conclusion, NAFLD is highly prevalent in the general population, is not associated with SLD, but is associated with many features of the metabolic syndrome...
  35. pmc Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study
    Arnt Erik Tjønna
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Circulation 118:346-54. 2008
    ..We compared moderate and high exercise intensity with regard to variables associated with cardiovascular function and prognosis in patients with the metabolic syndrome...
  36. ncbi Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994
    Stephen Cook
    Strong Children s Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Arch Pediatr Adolesc Med 157:821-7. 2003
    ..In adults the metabolic syndrome imposes a substantial risk for type 2 diabetes mellitus and premature coronary heart disease. Even so, no national estimate is currently available of the prevalence of this syndrome in adolescents...
  37. ncbi Childhood overweight, obesity, and the metabolic syndrome in developing countries
    Roya Kelishadi
    Department of Preventive Pediatric Cardiology, Isfahan Cardiovascular Research Center WHO Collaborating Center, Isfahan University of Medical Sciences, Isfahan, Iran
    Epidemiol Rev 29:62-76. 2007
    ....
  38. ncbi The metabolic syndrome and chronic kidney disease in U.S. adults
    Jing Chen
    Tulane University Schools of Medicine and Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
    Ann Intern Med 140:167-74. 2004
    ..The metabolic syndrome is a common risk factor for cardiovascular disease...
  39. pmc The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994
    Yong Woo Park
    Department of Family Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
    Arch Intern Med 163:427-36. 2003
    ..The extent to which the metabolic syndrome is associated with demographic and potentially modifiable lifestyle factors in the US population is unknown...
  40. ncbi Cohort Profile: the Whitehall II study
    Michael Marmot
    International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    Int J Epidemiol 34:251-6. 2005
  41. ncbi Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
    Shaista Malik
    Heart Disease Prevention Program, University of California, Irvine 92697, USA
    Circulation 110:1245-50. 2004
    ..We examined the impact of MetS on CHD, CVD, and overall mortality among US adults...
  42. ncbi Clinical application of C-reactive protein for cardiovascular disease detection and prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 107:363-9. 2003
  43. ncbi Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
    James B Meigs
    General Medicine Division, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2906-12. 2006
    ..Metabolic risk conferred by adiposity may be due to associated risk factor clustering...
  44. ncbi Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Naples, Italy
    JAMA 292:1440-6. 2004
    ..The metabolic syndrome has been identified as a target for dietary therapies to reduce risk of cardiovascular disease; however, the role of diet in the etiology of the metabolic syndrome is poorly understood...
  45. ncbi Appropriate waist circumference cutoff points for central obesity in Korean adults
    Sang Yeoup Lee
    Department of Family Medicine, College of Medicine, Pusan University, Pusan, Republic of Korea
    Diabetes Res Clin Pract 75:72-80. 2007
    ..The International Diabetes Federation consensus recently proposed a new definition for the diagnosis of metabolic syndrome, incorporating ethnically specific waist circumference (WC) cutoff points...
  46. ncbi Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K66, Atlanta, GA 30341, USA
    Diabetes Care 28:1228-30. 2005
  47. ncbi Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians?
    Chee Eng Tan
    Department of Endocrinology, Singapore General Hospital, Singapore, Republic of Singapore
    Diabetes Care 27:1182-6. 2004
    ..The objectives of this study were to determine the optimal waist circumference for diagnosing central obesity in Asians and to estimate the prevalence of the metabolic syndrome in an Asian population...
  48. ncbi Metabolic syndrome and risk of cardiovascular disease: a meta-analysis
    Andrea Galassi
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Am J Med 119:812-9. 2006
    ..We examined the association between the metabolic syndrome and risk of cardiovascular disease...
  49. ncbi Increasing prevalence of the metabolic syndrome among u.s. Adults
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 27:2444-9. 2004
    ..The prevalence of the metabolic syndrome is high among U.S. adults. Our purpose was to determine whether the prevalence of this syndrome has changed since 1988-1994...
  50. ncbi Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities study
    Pamela L Lutsey
    Division of Epidemiology and Community Health, University of Minnesota, School of Public Health, Minneapolis, USA
    Circulation 117:754-61. 2008
    ....
  51. ncbi A transgenic model of visceral obesity and the metabolic syndrome
    H Masuzaki
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
    Science 294:2166-70. 2001
    ..Increased adipocyte 11beta HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome...
  52. pmc First nationwide study of the prevalence of the metabolic syndrome and optimal cutoff points of waist circumference in the Middle East: the national survey of risk factors for noncommunicable diseases of Iran
    Alireza Delavari
    Endocrine and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Diabetes Care 32:1092-7. 2009
    ..The purpose of this study was to provide the first national estimate on the prevalence of the metabolic syndrome and its components and the first ethnic-specific cutoff point for waist circumference in the Eastern Mediterranean Region...
  53. ncbi The emerging epidemic of obesity in developing countries
    Andrew M Prentice
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 35:93-9. 2006
    ....
  54. ncbi Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 28:2745-9. 2005
    ..S. adults and to compare it with the prevalence estimated using the definition of the National Cholesterol Education Program (NCEP)...
  55. ncbi Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study
    Mark A Pereira
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2081-9. 2002
    ..Although diet has been postulated to influence IRS, the independent effects of dairy consumption on development of this syndrome have not been investigated...
  56. ncbi Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation
    Paresh Dandona
    Division of Endocrinology, Diabetes, and Metabolism, Diabetes Endocrinology Center of Western New York, State University of New York at Buffalo, and Kaleida Health, Buffalo, NY 14209, USA
    Circulation 111:1448-54. 2005
  57. pmc The effect of exercise on the cardiovascular risk factors constituting the metabolic syndrome: a meta-analysis of controlled trials
    Nele Pattyn
    Department of Rehabilitation Sciences, KU Leuven, Louvain, Belgium
    Sports Med 43:121-33. 2013
    ....
  58. ncbi Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms
    Jeong A Kim
    Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892 1632, USA
    Circulation 113:1888-904. 2006
    ..In the present review, we discuss pathophysiological mechanisms, including inflammatory processes, that couple endothelial dysfunction with insulin resistance and emphasize important therapeutic implications...
  59. ncbi Fructose, weight gain, and the insulin resistance syndrome
    Sharon S Elliott
    Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 76:911-22. 2002
    ....
  60. ncbi Fatty liver: a novel component of the metabolic syndrome
    Anna Kotronen
    Department of Medicine, Division of Diabetes, University of Helsinki, Finland, FIN 00029 HUCH, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 28:27-38. 2008
    ..Intervention studies have shown that liver fat can be decreased by weight loss, PPARgamma agonists, and insulin therapy...
  61. ncbi From the metabolic syndrome to NAFLD or vice versa?
    Ester Vanni
    Division of Gastro Hepatology, San Giovanni Battista Hospital, University of Turin, c so Bramante 88, 10126 Turin, Italy
    Dig Liver Dis 42:320-30. 2010
    ..Recently nuclear receptors have emerged as key regulators of lipid and carbohydrate metabolism for which specific pharmacological ligands are available, making them attractive therapeutic targets for NAFLD and NASH...
  62. ncbi Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice
    Chenhong Zhang
    Laboratory of Molecular Microbial Ecology and Ecogenomics, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, PR China
    ISME J 4:232-41. 2010
    ..Thus, diet has a dominating role in shaping gut microbiota and changes of some key populations may transform the gut microbiota of Wt animals into a pathogen-like entity relevant to development of MS, despite a complete host genome...
  63. ncbi Gender differences in the metabolic syndrome and their role for cardiovascular disease
    V Regitz-Zagrosek
    Center for Gender in Medicine and Cardiovascular Disease in Women, Charite and Deutsches Herzzentrum Berlin, Germany
    Clin Res Cardiol 95:136-47. 2006
    ....
  64. ncbi Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk
    Jean Pierre Despres
    Hôpital Laval Research Centre, 2725 Chemin Ste Foy, Pavilion Marguerite D Youville, 4th Floor, Quebec City, QC G1V4G5, Canada
    Arterioscler Thromb Vasc Biol 28:1039-49. 2008
    ....
  65. ncbi Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort
    Nicola M McKeown
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Diabetes Care 27:538-46. 2004
    ..The aim of this study was to examine the relation between carbohydrate-related dietary factors, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort...
  66. ncbi Adiponectin and metabolic syndrome
    Yuji Matsuzawa
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School, Sumitomo Hospital, Osaka, Japan
    Arterioscler Thromb Vasc Biol 24:29-33. 2004
    ..Adiponectin plasma levels decrease with the accumulation of visceral adipose tissue. In this review, we discuss the link of adiponectin to visceral adiposity, insulin resistance, and vascular diseases...
  67. ncbi Evaluation of oxidative stress and inflammation in obese adults with metabolic syndrome
    Jiri Skalicky
    Department of Clinical Biochemistry and Diagnostics, Regional Hospital of Pardubice, Pardubice, Czech Republic
    Clin Chem Lab Med 46:499-505. 2008
    ..The aim of our study was to evaluate the level of oxidative stress and inflammation in obese adults with and without metabolic syndrome...
  68. ncbi The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities study
    Ann Marie McNeill
    University of North Carolina, Chapel Hill, 137 E Franklin St, Chapel Hill, NC 28514, USA
    Diabetes Care 28:385-90. 2005
    ..To assess the magnitude of the association between the National Cholesterol Education Program's Third Adult Treatment Panel Report (ATP III) definition of the metabolic syndrome and cardiovascular disease (CVD)...
  69. ncbi Associations of TV viewing and physical activity with the metabolic syndrome in Australian adults
    D W Dunstan
    International Diabetes Institute, Melbourne, Victoria, Australia
    Diabetologia 48:2254-61. 2005
    ..We analysed a sample of Australian adults to determine the strength of associations of TV viewing and participation in physical activity with the metabolic syndrome...
  70. ncbi Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes 53:2087-94. 2004
    ..Of the NCEP criteria, waist circumference and triglycerides may best identify insulin resistance and visceral adiposity in individuals with a fasting plasma glucose <6.4 mmol/l...
  71. pmc The metabolic syndrome: A high-risk state for cancer?
    Stephanie Cowey
    Department of Pathology, University of Alabama at Birmingham, 701 South 19th St, LHRB Room 531, Birmingham, AL 35294 0007, USA
    Am J Pathol 169:1505-22. 2006
    ..We propose that the metabolic syndrome be considered as a high-risk state for certain types of cancer and that this relationship should be systematically explored across cancer types...
  72. ncbi The emergence of the metabolic syndrome with menopause
    Molly C Carr
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98195 6426, USA
    J Clin Endocrinol Metab 88:2404-11. 2003
    ..A better understanding of these metabolic changes with menopause will aid in the recognition and treatment of women at risk for future CVD, leading to appropriate interventions...
  73. ncbi Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis
    Panagiotis Anagnostis
    Department of Clinical Biochemistry, Royal Free Hospital Campus, University College Medical School, University College London, Pond Street, London, United Kingdom
    J Clin Endocrinol Metab 94:2692-701. 2009
    ..The present review summarizes the evidence on the potential role of cortisol in the pathogenesis of MetS and discusses new therapeutic approaches for these patients...
  74. ncbi The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation
    R K Simmons
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetologia 53:600-5. 2010
    ....
  75. pmc Metabolic syndrome in a sub-Saharan African setting: central obesity may be the key determinant
    Leopold Fezeu
    INSERM U780 IFR69, Epidemiological and Biostatistical Research, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
    Atherosclerosis 193:70-6. 2007
    ....
  76. ncbi A causal role for uric acid in fructose-induced metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 290:F625-31. 2006
    ..Fructose may have a major role in the epidemic of metabolic syndrome and obesity due to its ability to raise uric acid...
  77. ncbi Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Found
    Samuel Klein
    Circulation 110:2952-67. 2004
    ..The data demonstrate that weight loss and physical activity can prevent and treat obesity-related coronary heart disease risk factors and should be considered a primary therapy for obese patients with cardiovascular disease...
  78. pmc Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits
    Kati Kristiansson
    National Institute for Health and Welfare, University of Helsinki, Biomedicum, Helsinki, Finland
    Circ Cardiovasc Genet 5:242-9. 2012
    ..Furthermore, we tested for loci associated with multiple MetS component traits using factor analysis, and built a genetic risk score for MetS...
  79. pmc eNOS, metabolic syndrome and cardiovascular disease
    Paul L Huang
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Trends Endocrinol Metab 20:295-302. 2009
    ..This review focuses on endothelial nitric oxide synthase and summarizes evidence that a reduction in the bioavailability of endothelium-derived nitric oxide serves as a key link between metabolic disorders and cardiovascular risk...
  80. ncbi Resistin is an inflammatory marker of atherosclerosis in humans
    Muredach P Reilly
    Division of Cardiology, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 111:932-9. 2005
    ..Given the convergence of adipocyte and macrophage function, resistin may provide unique insight into links between obesity, inflammation, and atherosclerosis in humans...
  81. ncbi The metabolic syndrome: prevalence in worldwide populations
    Adrian J Cameron
    International Diabetes Institute, 250 Kooyong Road, Caulfield South 3162, Australia
    Endocrinol Metab Clin North Am 33:351-75, table of contents. 2004
    ..Regardless of the underlying genetic and environmental influences that mediate the prevalence of the metabolic syndrome, a higher prevalence will undoubtedly lead to undesirable outcomes such as cardiovascular disease...
  82. ncbi Metabolic syndrome in urban Asian Indian adults--a population study using modified ATP III criteria
    A Ramachandran
    Diabetes Research Centre, M V Hospital for Diabetes, WHO Collaborating Centre for Research, Education and Training in Diabetes, 4 Main Road, Royapuram, Chennai 600 013, India
    Diabetes Res Clin Pract 60:199-204. 2003
    ..To determine the prevalence of the Metabolic syndrome (MetS) using modified ATP III criteria in urban Asian Indian adults...
  83. ncbi 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort
    Elina Hypponen
    Center for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford St, London, WC1N 1EH, UK
    Diabetes 57:298-305. 2008
    ..Physiological interactions between vitamin D and IGF-1 are reported; this is the first study to investigate their combined associations with metabolic syndrome prevalence...
  84. ncbi American College of Endocrinology position statement on the insulin resistance syndrome
    Daniel Einhorn
    American College of Endocrinology
    Endocr Pract 9:237-52. 2003
  85. pmc Metabolic syndrome and incident diabetes: current state of the evidence
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 31:1898-904. 2008
    ..Our objective was to perform a quantitative review of prospective studies examining the association between the metabolic syndrome and incident diabetes...
  86. ncbi Alcohol consumption and the metabolic syndrome in Korean adults: the 1998 Korean National Health and Nutrition Examination Survey
    Yeong Sook Yoon
    Department of Family Medicine, Ilsan Paik Hospital, University of Inje, College of Medicine, Goyang City, Gyunggi Do, Korea
    Am J Clin Nutr 80:217-24. 2004
    ..The metabolic syndrome is associated with a high risk of cardiovascular disease morbidity and mortality. Light and moderate alcohol consumption have been associated with reduced cardiovascular disease morbidity and mortality...
  87. ncbi Metabolic syndrome and physical fitness in a sample of Azorean adolescents
    Carla Moreira
    Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal
    Metab Syndr Relat Disord 8:443-9. 2010
    ..This study aimed to estimate the prevalence of metabolic syndrome and its components and to analyze the relationship between metabolic syndrome and overall physical fitness levels in a sample of Azorean adolescents...
  88. ncbi Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults
    Manjula Kurella
    University of California San Francisco, Department of Nephrology, Laurel Heights, 3333 California Street, Suite 430, San Francisco, CA 94118 1211, USA
    J Am Soc Nephrol 16:2134-40. 2005
    ..24 (95% CI, 1.01 to 1.51). The metabolic syndrome is independently associated with an increased risk for incident CKD in nondiabetic adults...
  89. ncbi Prevalence of the metabolic syndrome among 40,698 Korean metropolitan subjects
    Won Young Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung dong, Jongro Ku, Seoul 110746, South Korea
    Diabetes Res Clin Pract 65:143-9. 2004
    ..No published study has reported the prevalence of the metabolic syndrome in Asians using Adults Treatment Panel III (ATP III) criteria, comparing results with that using the obesity criteria of the Asia-Pacific region...
  90. ncbi Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study
    Aimin Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Circulation 115:1537-43. 2007
    ..In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria...
  91. ncbi Independent associations of body-size adjusted fat mass and fat-free mass with the metabolic syndrome in Chinese
    Jing Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Ann Hum Biol 36:110-21. 2009
    ..Excess fat leads to adverse health outcomes. Most previous studies investigating body fatness using BMI or fat percentage, which contain both fat mass and fat-free mass, were not able to differentiate the exposure...
  92. ncbi Non-high-density-lipoprotein cholesterol and cardiovascular risk factors among adolescents with and without impaired fasting glucose
    Jian Liu
    Department of Community Health Sciences, Brock University, St Catharines, ON L2S3A1, Canada
    Appl Physiol Nutr Metab 34:136-42. 2009
    ..Thus, the levels of non-HDL cholesterol may be an important indicator in monitoring cardiovascular disease risk among adolescents with IFG...
  93. pmc The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus
    Henry N Ginsberg
    Department of Medicine and the Irving Institute for Clinical and Translational Research, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Cardiometab Syndr 4:113-9. 2009
    ..In an accompanying article, current pharmacotherapies available for the management of atherogenic dyslipidemia in individuals with MS or T2DM are discussed...
  94. ncbi Helicobacter pylori infection is significantly associated with metabolic syndrome in the Japanese population
    Toshiaki Gunji
    Center for Preventive Medicine, Kanto Medical Canter, NTT East, Tokyo, Japan
    Am J Gastroenterol 103:3005-10. 2008
    ..Metabolic syndrome comprises a cluster of metabolic abnormalities leading to insulin resistance and atherosclerosis, and Helicobacter pylori is thought to be a contributing factor...
  95. ncbi Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease
    Nicholas Michael Morton
    Molecular Metabolism Group after University of Edinburgh, Centre for Cardiovascular Sciences, Edinburgh, United Kingdom
    Mol Cell Endocrinol 316:154-64. 2010
    ..The weight of evidence, much of it gained from animal models, suggests that therapeutic inhibition of 11beta-HSD1 will be beneficial in most cellular contexts, with clinical trials supportive of this concept...
  96. ncbi Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis
    Valerie Paradis
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Hepatology 49:851-9. 2009
    ..001). Five HCCs, all from the MS group, developed on a preexisting liver cell adenoma, with three of them showing typical histological features of telangiectatic adenoma...
  97. pmc The role of interleukin-18 in the metabolic syndrome
    Marius Trøseid
    Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ulleval, Oslo, Norway
    Cardiovasc Diabetol 9:11. 2010
    ..The purpose of this review is to outline the role of IL-18 in the metabolic syndrome, with particular emphasis on cardiovascular risk and the potential effect of life style interventions...
  98. ncbi Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study
    Ioanna Tzoulaki
    Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, W2 1PG London, United Kingdom
    Am J Epidemiol 171:989-98. 2010
    ..These results showed that growth during the immediate postnatal period is associated with adulthood obesity and BP. Lifestyle changes from early life might be important in reducing adulthood obesity and high-BP risk...
  99. ncbi Metabolic syndrome and risk of acute myocardial infarction a case-control study of 26,903 subjects from 52 countries
    Andrew Mente
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Am Coll Cardiol 55:2390-8. 2010
    ..This study examines the risk of acute myocardial infarction (MI) conferred by the metabolic syndrome (MS) and its individual factors in multiple ethnic populations...
  100. ncbi Soy protein intake has sex-specific effects on the risk of metabolic syndrome in middle-aged and elderly Chinese
    An Pan
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Nutr 138:2413-21. 2008
    ..049). It was not associated with any component in women. In conclusion, habitual soy protein intake may have sex-dependent effects on risk of MetS in middle-aged and elderly Chinese...
  101. ncbi Patterns of alcohol consumption and the metabolic syndrome
    Amy Z Fan
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Clin Endocrinol Metab 93:3833-8. 2008
    ..This may be due to variations in drinking patterns and different alcohol effects on the metabolic syndrome components. This study is designed to examine the relationship between alcohol consumption patterns and the metabolic syndrome...

Research Grants80

  1. Exercise Training in Insulin Resistant Non-Diabetics
    Ira Goldfine; Fiscal Year: 2006
    ..In this group, insulin resistance, in the absence of hyperglycemia, predisposes them to: 1) T2D; 2) the Metabolic Syndrome X (hypertension, dyslipidemia, and coronary artery disease); and 3) cancer...
  2. Functional role of the Spot 14 gene in dietary regulation of milk fat synthesis
    KEVIN JOHN HARVATINE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The incidence of obesity and metabolic syndrome X are increasing towards epidemic proportions in the US and developed world...
  3. Can IGF-I/IGFBP-3 Reverse Central Fat Accumulation?
    Morris Schambelan; Fiscal Year: 2005
    ..insulin resistance, dyslipidemia, lipoatrophy, and central fat accumulation, findings reminiscent of metabolic syndrome X and commonly referred to as HIV-associated lipodystrophy syndrome...
  4. LIPEMIA--CARBOHYDRATE AND GLYCERIDE METABOLISM
    Gerald Reaven; Fiscal Year: 2000
    ..As such, this study will provide considerable new knowledge relevant to the link between Syndrome X and atherogenesis. ..
  5. METABOLISM AND GENETICS OF HYPOBETALIPOPROTEINEMIA
    Gustav Schonfeld; Fiscal Year: 2007
    ..90, p=0.001). Our aim is to extend these studies in our FHBL subjects and to patients with the metabolic Syndrome X, and to evaluate the importance of metabolic "risk factors" such as body weight, insulin resistance on the ..
  6. Interactions between Imidazoline and Insulin Receptors
    Lincoln Edwards; Fiscal Year: 2005
    ..independent research program, relevant not only to cardiovascular disease, but also to type 2 diabetes and Metabolic Syndrome X. Metabolic Syndrome X affects 75 million Americans, and is a growing epidemic worldwide...
  7. INFLAME: Inflammation and Exercise
    Timothy Church; Fiscal Year: 2007
    ....
  8. FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGY
    Abdulmaged Traish; Fiscal Year: 2003
    ....
  9. C-Reactive Protein and Exercise in Postmenopausal Women
    Timothy Church; Fiscal Year: 2003
    ..These studies represent an innovative, unique, timely, and cost-effective opportunity to quickly explore the relation between CRP, physical activity, and HRT. ..
  10. Social stress-induced changes in energy homeostasis
    KELLIE TAMASHIRO; Fiscal Year: 2005
    ..abstract_text> ..
  11. Dietary Glycemic Load, Body Weight, and Blood Lipids
    Yunsheng Ma; Fiscal Year: 2005
    ..abstract_text> ..
  12. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
    ..CRP augments oxidative stress and inflammation in the diabetic milieu will eventually lead to therapies targeted at reducing inflammation and oxidative stress in diabetes and resulting in a decrease in vasculopathies ..
  13. EXERCISE FOR ELDERLY PERIPHERAL REVASCULARIZED PATIENTS
    Andrew Gardner; Fiscal Year: 2004
    ....
  14. TISSUE-CRYSTAL INTERACTION CA OXALATE NEPHROLITHIASIS
    Saeed Khan; Fiscal Year: 2003
    ..We can follow various events of nephrolithiasis in the animal model and cats explore the outcome of renal epithelial cell exposure to oxalate and calcium oxalate crystals in the cell cultures. ..
  15. Influences of the prenatal environment on metabolic programming
    KELLIE TAMASHIRO; Fiscal Year: 2008
    ..abstract_text> ..
  16. Endothelial Cell in Progressive Renal Disease
    Richard Johnson; Fiscal Year: 2009
    ..abstract_text> ..
  17. Withdrawal of statins and vascular dysfunction
    LUIGI CUBEDDU; Fiscal Year: 2004
    ..Our study may provide the basis for preventive and corrective interventions to millions of people that are under statin treatment. ..
  18. CaP, crystal responsible for idiopathic nephrolithasis
    Saeed Khan; Fiscal Year: 2008
    ..Type density and size must conform to limits and specifications provided in the PHS 398Instructions. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  19. Arginine and Ovine Model for Fetal Growth Restriction
    Guoyao Wu; Fiscal Year: 2007
    ..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. [unreadable] [unreadable] [unreadable]..
  20. ADAM: Androgen Deprivation vs. Antiandrogen Monotherapy
    Matthew Smith; Fiscal Year: 2004
    ..In addition, this project will provide important insights into the relative contributions of testosterone and estrogen in bone metabolism, and maintenance of muscle size and strength in older men. ..
  21. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2005
    ..This new knowledge will be applied to the ultimate goal of site-directed gene delivery aimed at the newly identified vulnerable loci in hypothalamic signaling to curb overeating and abnormal weight gain. ..
  22. Home-based vs. Supervised Exercise for Claudicants
    Andrew W Gardner; Fiscal Year: 2010
    ....
  23. CARDIOVASCULAR NUTRITION IN MEDICAL EDUCATION
    Scott Grundy; Fiscal Year: 2002
    ..The long term goal is to produce graduates who routinely address nutrition and exercise for cardiovascular health with their patients. ..
  24. Autonomic function and insulin resistance in a multiethnic population
    Andrew Grandinetti; Fiscal Year: 2007
    ..any observed ethnic disparities in autonomic function? Is the questionnaire-derived Composite Autonomic Symptom Scale (COMPASS) correlated with autonomic function in Hawaii's multiethnic population? [unreadable] [unreadable]..
  25. 2007 International Peripheral Nerve Society Meeting at Snowbird, Utah
    A Smith; Fiscal Year: 2007
    ..The meeting directly impacts public health and patient care by disseminating important new ideas (both research and therapeutic) and by developing consensus guidelines. [unreadable] [unreadable] [unreadable]..
  26. The role of sphingolipids in the pancreatic beta cell
    Scott Summers; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  27. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
  28. Outcomes of Sleep Disorders in Older Men
    Elizabeth Barrett Connor; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  29. CNS Action of Appetite Suppressant Aminosterol
    Rexford S Ahima; Fiscal Year: 2010
    ..Understanding of the central neuronal actions MSI-1436 may elucidate novel targets for the treatment of obesity and related diseases. ..
  30. Reduced Carbohydrate Diet Intervention for PCOS
    Barbara A Gower; Fiscal Year: 2010
    ..the lower GL diet will be more effective in decreasing insulin secretion, increasing insulin sensitivity, decreasing ectopic adipose tissue, decreasing inflammation, and improvin% (<10% saturated fat) saturated fat) ..
  31. Genome-Wide Association Scan of Polycystic Ovary Syndrome Phenotypes
    Andrea Dunaif; Fiscal Year: 2010
    ..This information should lead to more effective and specific treatments as well as to disease prediction and prevention. ..
  32. Obesity, Metabolic Syndrome, Meal-Related Glycemia
    Barry E Hurwitz; Fiscal Year: 2010
    ..This research is an essential step toward understanding in persons with MSX the role of postprandial glycemic regulation in accelerated CHD pathogenesis. ..
  33. Health benefits of Aerobic and Resistance Training in individuals with Diabetes
    Timothy Church; Fiscal Year: 2009
    ..The primary outcome measure is HbA1c, an integrated measure of blood glucose control over the past 8-12 weeks. ..
  34. Diet, Activity, Obesity & The Built Environment Dynamics
    Barry Popkin; Fiscal Year: 2009
    ..A central issue is determining modifiable environment factors that may reduce ethnic and socioeconomic differentials in health status. ..
  35. You are what you eat: Longitudnal associations between the neighborhood food envi
    Kiyah Duffey; Fiscal Year: 2008
    ..Results from this study will identify factors that could be targeted for the design and development of community environments that improve individuals' diets and support healthy behaviors. [unreadable] [unreadable] [unreadable]..
  36. Proteomic biomarkers for lymphoma
    GERALD DENIS; Fiscal Year: 2008
    ..The heuristic should be adaptable and extendable to a wide spectrum of human hematologic malignancies, including myeloid leukemias. [unreadable] [unreadable] [unreadable]..
  37. Skeletal Muscle Microcirculation in Obese Zucker Rats
    Jefferson Frisbee; Fiscal Year: 2009
    ..factors, including obesity, hypertension and dyslipidemia, a multi-pathology state develops: the metabolic Syndrome X. The obese Zucker rat (OZR) provides an excellent model for examining the impact of Syndrome X on the ..
  38. Mechanisms Linking Depression to Cardiovascular Risk
    Viola Vaccarino; Fiscal Year: 2010
    ..abstract_text> ..
  39. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..abstract_text> ..
  40. Mentored Clinical Research Scholar Program
    Henry Ginsberg; Fiscal Year: 2006
    ..They believe firmly that this K12 CRS Program will have an immense impact on the future of patient-oriented research in the next decades. [unreadable] [unreadable] [unreadable]..
  41. HIV/HCV Co-infection: HAART and CVD Pathophysiology
    Barry Hurwitz; Fiscal Year: 2006
    ..abstract_text> ..
  42. QTL ANALYSIS OF DEPRESSIVE, STRESS HYPERREACTIVE BEHAVIO
    Eva Redei; Fiscal Year: 2003
    ..We hypothesize that the characterization of QTL and candidate genes in this animal model will facilitate the identification of depression-related genes in humans. ..
  43. Mechanisms of Estrogen Repression of TNF-a Transcription
    Dale Leitman; Fiscal Year: 2003
    ..abstract_text> ..
  44. CHILD HEALTH EFFECTS OF RAPID SOCIO-DEMOGRAPHIC CHANGE
    Barry Popkin; Fiscal Year: 2004
    ..Finally, we will compare results across countries to determine whether there is a consistent pattern or structure of relationships across countries at different levels of development. ..
  45. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
    ..This mechanism may contribute to the ability of the coronary circulation to maintain cardiac perfusion and avoid ischemia during the early stages of coronary artery disease when NO-dependent dilation is compromised. ..
  46. Identification of biomarkers of fatty acid intake
    Hannia Campos; Fiscal Year: 2002
    ..abstract_text> ..
  47. RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
    Evelyn Talbott; Fiscal Year: 2005
    ..The investigators state that this study has the potential to identify the determinants of early SCA in this high-risk group of women and has important implications for primary as well as secondary prevention. ..
  48. High Dose Alpha Tocopherol and Carotid Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2004
    ..This study has the additional novelty of correlating biomarkers of oxidative stress and inflammation with a cardiovascular endpoint and will establish whether high dose AT decreases atherosclerosis progression. ..
  49. USE OF ANTIOXIDANT SUPPLEMENTS AND OXIDATIVE DNA DAMAGE
    Marian Neuhouser; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  50. CVD Predictors of Cognitive Function Trajectory over 20 Years
    Elizabeth L Barrett Connor; Fiscal Year: 2010
    ..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..
  51. Chronic Kidney Disease with Benign Prostatic Hyperplasia
    ANDREW RULE; Fiscal Year: 2004
    ..Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD. ..
  52. CHRONIC ISCHEMIC LEFT VENTRICULAR DYSFUNCTION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The drug we will test is carvedilol because of its unique adrenergic inhibitor properties as well as its anti-oxidant and anti-apoptotic properties. ..
  53. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  54. Vascular Depression and Function in Older Latinos
    HECTOR GONZALEZ; Fiscal Year: 2007
    ..abstract_text> ..
  55. Population-Based Reference Ranges for Testosterone
    VASAN S RAMACHANDRAN; Fiscal Year: 2010
    ..These steps will facilitate the development of rational criteria for classifying men into androgen-deficient and androgen-replete categories. ..
  56. Posttraumatic Stress Disorder and Cardiovascular Disease
    Viola Vaccarino; Fiscal Year: 2007
    ..Efforts toward the prevention, early identification and treatment of PTSD and the identification of factors that mediate its adverse effects could reduce morbidity and mortality from CVD. ..
  57. Marital Adjustment, Depression and Myocardial Infarction
    Linda Gallo; Fiscal Year: 2003
    ..abstract_text> ..
  58. RBC MASS, ANS INTEGRITY & SYNCOPE SUSCEPTIBILITY IN CFS
    Barry Hurwitz; Fiscal Year: 2003
    ....
  59. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 2002
    ....
  60. Metabolic Syndrome Following Transplant for Leukemia
    KEVIN S BAKER; Fiscal Year: 2010
    ....
  61. MEDICATION ADHERENCE AND OUTCOMES IN SCHIZOPHRENIA
    Dawn Velligan; Fiscal Year: 2004
    ..Moreover, we hypothesize that compliance and functioning will return to baseline levels six months after discontinuation of treatment. ..
  62. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2004
    ..abstract_text> ..
  63. An Interdisciplinary Strategy for Obesity (RMI)
    Barry Popkin; Fiscal Year: 2006
    ..We will apply the knowledge gained from our interdisciplinary research to achieve our long-term goal of developing novel treatment and prevention interventions for obesity. [unreadable] [unreadable]..
  64. GENE EFFECTS ON STRENGTH RESPONSES TO AGE AND EXERCISE
    Bernard Hurley; Fiscal Year: 2005
    ..Conversely, identifying persons who improve their strength and muscle mass the least with strength training would allow them to focus on interventions that might be more efficacious for them. ..
  65. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David Clemmons; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  66. Risk for Depression Stress and Neuroendocrine Function
    AUDREY TYRKA; Fiscal Year: 2008
    ..This R01 proposal will entail a prospective longitudinal investigation of the effects of childhood adversity and maternal mood and anxiety disorders on the development of neuroendocrine dysfunction and psychopathology. ..
  67. Long-term follow-up of postobese black and white women
    Barbara Gower; Fiscal Year: 2008
    ..abstract_text> ..
  68. INSULIN RESISTANCE IN PCOS--SEQUELAE AND TREATMENT
    RICHARD LEGRO; Fiscal Year: 2005
    ..Improving insulin action through diet and exercise, with and without weight loss, will result in lowered circulating insulin levels, lowered androgens and increased ovulatory frequency rate in PCOS women. ..
  69. Are Volume Standards Accurate Measures of Quality?
    Laurent Glance; Fiscal Year: 2005
    ..abstract_text> ..
  70. Psychological Stress and Immune Response to Vaccination
    ANNA MARSLAND; Fiscal Year: 2007
    ..Antibody responses will be measured at the time of the second and third does of vaccine and, during the follow-up period, 6 and 12 months following completion of the vaccination series. ..
  71. Pregnancy and Risk Factors for CVD and Type 2 Diabetes
    Erica Gunderson; Fiscal Year: 2006
    ..The study will also assess whether breastfeeding has beneficial effects on risk factors that may help prevent heart disease and diabetes in women. ..
  72. A Risk Score for Cardiovascular Disease in Older Adult
    Arun Karlamangla; Fiscal Year: 2008
    ..The proposed research will lead to better risk assessment and to improved targeting of preventive interventions in these older adults. ..
  73. MAP KINASES IN OLIGODENDROCYTE CELL SIGNALING
    Narayan Bhat; Fiscal Year: 2005
    ..Putative MAPK-responsive elements and relevant binding activities will be determined by deletion and gel shift analyses ..
  74. 2003 Kern Aspen Lipid Conference: Integrative Mechanisms
    Lawrence Rudel; Fiscal Year: 2003
    ..The timeliness of this meeting is viewed as a strength. ..
  75. Ninth International Conference on Endothelin (ET-9)
    Donald Kohan; Fiscal Year: 2005
    ..abstract_text> ..
  76. SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSIS
    Paul Ridker; Fiscal Year: 2002
    ....
  77. Oxidative Stress and Genetics of Prehypertension
    Shawna Nesbitt; Fiscal Year: 2004
    ..abstract_text> ..