Genomes and Genes
Summary: The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.
Publications266 found, 100 shown here
- Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fracturesBarbara M Obermayer-Pietsch
Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Karl Franzens University Hospital, Graz, Austria
J Bone Miner Res 19:42-7. 2004Evidence that genetic disposition for adult lactose intolerance significantly affects calcium intake, bone density, and fractures in postmenopausal women is presented...
- The effects of adult-type hypolactasia on body height growth and dietary calcium intake from childhood into young adulthood: a 21-year follow-up study--the Cardiovascular Risk in Young Finns StudyTerho Lehtimaki
Department of Clinical Chemistry, Tampere University Hospital, PO Box 2000, FI33521 Tampere, Finland
Pediatrics 118:1553-9. 2006..We studied whether this polymorphism was associated with body height growth, the use of milk products, or dietary calcium intake...
- Association of lactose sensitivity with inflammatory bowel disease--demonstrated by analysis of genetic polymorphism, breath gases and symptomsP Eadala
Department of Gastroenterology, Morriston Hospital, Swansea, UK
Aliment Pharmacol Ther 34:735-46. 2011..The genetic marker CC₁₃₉₁₀, on chromosome2, with measurement of breath hydrogen and methane, and gut and systemic symptoms, are now the most comprehensive tests for evaluating sensitivity to lactose...
- Identification of a variant associated with adult-type hypolactasiaNabil Sabri Enattah
Department of Molecular Medicine, National Public Health Institute, Haartmaninkatu 8, PO Box 104, Fin 00251 Helsinki, Finland
Nat Genet 30:233-7. 2002Adult-type hypolactasia, also known as lactase non-persistence (lactose intolerance), is a common autosomal recessive condition resulting from the physiological decline in activity of the lactase-phlorizin hydrolase (LPH) in intestinal ..
- Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndromeA K Campbell
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF103NB, UK
Toxicology 278:268-76. 2010..We propose it will lead to a new understanding of the molecular mechanism of type 2 diabetes and some cancers...
- NIH consensus development conference statement: Lactose intolerance and healthFrederick J Suchy
Jack and Lucy Clark Department of Pediatrics, Mount Sinai School of Medicine of New York University, Mount Sinai Kravis Children s Hospital, New York, New York, USA
NIH Consens State Sci Statements 27:1-27. 2010To provide health care providers, patients, and the general public with a responsible assessment of currently available data on lactose intolerance and health.
- Colonic fermentation may play a role in lactose intolerance in humansTao He
Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands
J Nutr 136:58-63. 2006..to the small intestinal lactase activity and transit time, colonic processing of lactose may play a role in lactose intolerance. We investigated whether colonic fermentation of lactose is correlated with lactose intolerance...
- Prevalence and presentation of lactose intolerance and effects on dairy product intake in healthy subjects and patients with irritable bowel syndromeJianfeng Yang
Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
Clin Gastroenterol Hepatol 11:262-268.e1. 2013..We assessed lactose absorption and tolerance and the intake of dairy products in healthy volunteers (controls) and patients with diarrhea-predominant IBS (D-IBS)...
- [Molecular diagnosis and frequencies of primary hypolactasia in populations of RUSSIA and neighboring countries]S A Borinskaia
Mol Biol (Mosk) 40:1031-6. 2006..Practical application of this type of diagnostics would be a step towards the individual-oriented medicine...
- Methods and functions: Breath testsBarbara Braden
John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
Best Pract Res Clin Gastroenterol 23:337-52. 2009..The knowledge of potential pitfalls and influencing factors are important for correct interpretation of breath test results before drawing clinical conclusions...
- Systemic lactose intolerance: a new perspective on an old problemS B Matthews
Department of Medical Biochemistry and Immunology, Llandough Hospital, Cardiff and Vale NHS Trust, Penarth Vale of Glamorgan, UK
Postgrad Med J 81:167-73. 2005..symptoms and a six hour breath hydrogen test, provides a new approach to the clinical management of lactose intolerance. The key is the prolonged effect of dietary removal of lactose...
- Benefits of breath hydrogen testing after lactulose administration in analysing carbohydrate malabsorptionJohn P Bate
Departments of Medicine and Gastroenterology, Monash University, Box Hill Hospital, Box Hill, Victoria, Australia
Eur J Gastroenterol Hepatol 22:318-26. 2010..We examined the contribution of breath testing after lactulose administration to the conduct and interpretation of breath hydrogen responses after fructose and lactose administration...
- Improved parameters of lactose maldigestion using lactuloseA Szilagyi
Department of Medicine, The Sir Mortimer B. Davis Jewish General Hospital Faculty of Medicine, McGill University Montreal, Quebec, Canada
Dig Dis Sci 46:1509-19. 2001..Fecal beta-galactosidase significantly increased after lactulose. This study supports the notion that lactulose and lactose may have similar clinical effects...
- Sugar malabsorption in functional abdominal bloating: a pilot study on the long-term effect of dietary treatmentFernando Fernández-Bañares
Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Plaza Dr Robert 5, 08221 Terrassa, Barcelona, Spain
Clin Nutr 25:824-31. 2006..Gas-related complaints (i.e., passage of flatus), which are present in a subgroup of these patients, might be associated with carbohydrate malabsorption...
- Lactose malabsorption and intolerance and peak bone massMichele Di Stefano
Gastroenterology Unit, IRCCS S Matteo Hospital, University of Pavia, Pavia, Italy
Gastroenterology 122:1793-9. 2002..The purpose of this study was to evaluate whether lactose intolerance interferes with the achievement of an adequate peak bone mass in young adults.
- Lactose intolerance in patients with chronic functional diarrhoea: the role of small intestinal bacterial overgrowthJ Zhao
Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Aliment Pharmacol Ther 31:892-900. 2010Many studies report a high prevalence of lactose intolerance in patients with functional, gastrointestinal disease.
- A novel acid-stable, acid-active beta-galactosidase potentially suited to the alleviation of lactose intoleranceShane O'Connell
Shannon Applied Biotechnology Centre, IT Tralee, Tralee, Co Kerry, Ireland
Appl Microbiol Biotechnol 86:517-24. 2010..5-fold more lactose than did the commercial supplemental enzyme. The acid-stable, acid-active enzyme, along with the novel two-segment delivery system, may prove beneficial in the more effective treatment of lactose intolerance.
- A randomized trial of Lactobacillus acidophilus BG2FO4 to treat lactose intoleranceJ R Saltzman
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and the Tufts University School of Medicine, Boston, USA
Am J Clin Nutr 69:140-6. 1999b>Lactose intolerance is the most common disorder of intestinal carbohydrate digestion. Lactobacillus acidophilus BG2FO4 is a strain of lactobacilli with properties of marked intestinal adherence and high beta-galactosidase activity.
- Milk consumption and lactose intolerance in adultsRong Qiao
Department of Nutrition and Food Safety, Sichuan University, Chengdu 610041, Sichuan, China
Biomed Environ Sci 24:512-7. 2011To investigate relations between milk consumption and lactose intolerance (LI) in adults and to explore the effect of milk consumption on lactase activity.
- Lactose malabsorption, calcium intake, and bone mass in children and adolescentsLilian C da Silva Medeiros
Department of Nutrition, Federal University of Sao Paulo, Brazil
J Pediatr Gastroenterol Nutr 54:204-9. 2012..The objective of the present study was to evaluate the calcium intake and bone mass in children and early adolescents in accordance with their absorption capacity to lactose...
- Differential impact of lactose/lactase phenotype on colonic microfloraAndrew Szilagyi
Division of Gastroenterology, Department of Medicine, McGill School of Medicine, Montreal, Quebec
Can J Gastroenterol 24:373-9. 2010..Prebiotic effects likely favour lactose maldigesters who experience lactose spilling into their colon...
- Lactose intolerance: lack of evidence for short stature or vitamin D deficiency in prepubertal childrenNithya Setty-Shah
Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 8:e78653. 2013The health consequences of lactose intolerance (LI) are unclear.
- Application relevant studies of fungal beta-galactosidases with potential application in the alleviation of lactose intoleranceS O'Connell
Department of Chemical and Environmental Sciences and Materials and Surface Sciences Institute, University of Limerick, Limerick City, Ireland
Appl Biochem Biotechnol 149:129-38. 2008..activity potentially suited for use as a lactase digestive supplement in the treatment of lactose intolerance. The crude preparation contained two beta-galactosidase activities, beta-gal 1 and beta-gal 2, which were ..
- Fructose and lactose intolerance and malabsorption testing: the relationship with symptoms in functional gastrointestinal disordersC H Wilder-Smith
Gastroenterology Group Practice, Brain Gut Research Group, Bern, Switzerland
Aliment Pharmacol Ther 37:1074-83. 2013The association of fructose and lactose intolerance and malabsorption with the symptoms of different functional gastrointestinal disorders (FGID) remains unclear.
- Does lactose intolerance predispose to low bone density? A population-based study of perimenopausal Finnish womenR Honkanen
Institute of Community Medicine, University of Tromsø, Norway
Bone 19:23-8. 1996..We examined the relationship of self-reported lactose intolerance (LI) to bone mineral density (BMD) in perimenopausal Finnish women...
- Lactose intolerance: analysis of underlying factorsR J Vonk
Laboratory Nutrition and Metabolism, Laboratory Centre CMC V, Y2147, University Hospital Groningen, PO Box 30 001, 9700 Groningen, The Netherlands
Eur J Clin Invest 33:70-5. 2003We studied the degree of lactose digestion and orocecal transit time (OCTT) as possible causes for the variability of symptoms of lactose intolerance (LI) in a sample of a population with genetically determined low lactase activity.
- Peroral gene therapy of lactose intolerance using an adeno-associated virus vectorM J During
Department of Molecular Medicine, University of Auckland School of Medicine, New Zealand
Nat Med 4:1131-5. 1998..lamina propria cells, and that this approach results in long-term phenotypic recovery in an animal model of lactose intolerance. A gene 'pill' associated with highly efficient and stable gene expression might be a practical and cost-..
- Consensus report of the National Medical Association. The role of dairy and dairy nutrients in the diet of African AmericansWilma J Wooten
National Medical Association, Women Section, San Diego, CA, USA
J Natl Med Assoc 96:5S-31S. 2004
- Fermentation, fermented foods and lactose intoleranceN W Solomons
Center for Studies of Sensory Impairment, Aging and Metabolism CeSSIAM, Guatemala City, Guatemala
Eur J Clin Nutr 56:S50-5. 2002..In this way, the issues of lactose intolerance and of fermented foods are joined...
- [Effect of probiotics and yogurt on colonic microflora in subjects with lactose intolerance]Yan Zhong
Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China
Wei Sheng Yan Jiu 35:587-91. 2006To study the effects of probiotics and yoghurt supplementation on colonic microflora in subjects with lactose intolerance (LI).
- The role of colonic metabolism in lactose intoleranceT He
TI Food and Nutrition, Wageningen, The Netherlands
Eur J Clin Invest 38:541-7. 2008Lactose maldigestion and intolerance affect a large part of the world population. The underlying factors of lactose intolerance are not fully understood. In this review, the role of colonic metabolism is discussed, i.e...
- A re-appraisal of lactose intoleranceL K Harrington
Department of Gastroenterology, Leicester General Hospital, Leicester, UK
Int J Clin Pract 62:1541-6. 2008Lactose, beta-galactose-1,4-glucose, is hydrolysed by the enzyme lactase. Lactose intolerance occurs when lactase deficiency causes clinical symptoms.
- Lactose intolerance revealed by severe resistance to treatment with levothyroxineManuel Muñoz-Torres
Department of Endocrinology, Hospital Universitario San Cecilio de Granada, Granada, Spain
Thyroid 16:1171-3. 2006..The incidence of lactose intolerance in Caucasian adult patients is 7%-20%, but the association with resistance to treatment with oral LT(4) is ..
- Self-perceived lactose intolerance results in lower intakes of calcium and dairy foods and is associated with hypertension and diabetes in adultsTheresa A Nicklas
US Department of Agriculture Agricultural Research Service, Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
Am J Clin Nutr 94:191-8. 2011Self-perceived lactose intolerance may result in adverse dietary modifications; thus, more studies are needed to understand the prevalence of self-perceived lactose intolerance and how it relates to calcium intake and selected health ..
- A novel method for diagnosis of adult hypolactasia by genotyping of the -13910 C/T polymorphism with Pyrosequencing technologyT K Nilsson
Dept of Clinical Chemistry and the Clinical Research Center, Orebro University Hospital, Orebro, Sweden
Scand J Gastroenterol 39:287-90. 2004....
- Lactose digestion and the evolutionary genetics of lactase persistenceCatherine J E Ingram
Department of Genetics Evolution and Environment, University College London, London, UK
Hum Genet 124:579-91. 2009....
- [Frequency of bacterial overgrowth in patients with clinical lactose intolerance]Abel Novillo
Departamento de Medicina, Sección Gastroenterología, CEMIC Centro de Educaciín Mèdica e Investigaciones Clínicas, Buenos Aires, Argentina
Acta Gastroenterol Latinoam 40:221-4. 2010..This intolerance could be associated with an intestinal bacterial overgrowth or an increased fermentative intestinal profile and not due to lactose malabsorption...
- The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activityTine G K Jensen
Department of Cellular and Molecular Medicine, Panum Institute, Building 6 4, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen N, Denmark
Hum Genet 130:483-93. 2011..Binding sites for Oct-1 and HNF1α surrounding the -14010 position were identified by gel shift assays, which indicated that -14010*C has greater binding affinity to Oct-1 than -14010*G...
- High frequency of lactose intolerance in a prehistoric hunter-gatherer population in northern EuropeHelena Malmström
Department of Evolutionary Biology, Uppsala University, 752 36 Uppsala, Sweden
BMC Evol Biol 10:89. 2010..This genetic trait is believed to have evolved within a short time period and to be related with the emergence of sedentary agriculture...
- Subjective perception of lactose intolerance does not always indicate lactose malabsorptionFrancesc Casellas
Digestive System Research Unit, Hospital Universitari Vall d Hebron, Barcelona, Spain
Clin Gastroenterol Hepatol 8:581-6. 2010Symptomatic lactose intolerance is common; however, abdominal symptoms that patients experience after ingestion of lactose-containing foods can have causes beyond lactose malabsorption...
- Diagnosis of lactose intolerance and the "nocebo" effect: the role of negative expectationsPiero Vernia
Gastroenterologia A, Dipartimento di Scienze Cliniche, Sapienza Universita di Roma, Viale del Policlinico, 00161 Roma, Italy
Dig Liver Dis 42:616-9. 2010Diagnosis of lactose intolerance is based on a "positive" H(2) breath test associated with abdominal symptoms...
- Lactose intolerance in active Crohn's disease: clinical value of duodenal lactase analysisChristian Von Tirpitz
Department of Medicine I, University of Ulm, Ulm, Germany
J Clin Gastroenterol 34:49-53. 2002..Patients with active Crohn's disease (CD) often report having abdominal symptoms after ingestion of milk products, but the pathomechanism for lactose malabsorption seems to be complex...
- Lactose malabsorption in Khants in western SiberiaM Lember
University of Tartu, Estonia
Scand J Gastroenterol 30:225-7. 1995..We wanted to estimate the prevalence of selective lactose malabsorption (SLM) in Khants, a small Finno-Ugric population living in Western Siberia who have traditionally consumed no milk in adulthood...
- Lactose intolerance in infants with gluten-sensitive enteropathy: frequency and clinical characteristicsNedeljko Radlovic
University Children s Hospital, Belgrade, Serbia
Srp Arh Celok Lek 137:33-7. 2009Secondary lactose intolerance (SLI) belongs to the rarer manifestations of gluten-sensitive enteropathy (GSE). It occurs in more severe forms of the disease and its presence contributes significantly to the degree of its expression.
- The molecular basis of lactose intoleranceAnthony K Campbell
Department of Medical Biochemistry and Immunology, Wales College of Medicine, Cardiff University, Cardiff, CF14 XN, UK
Sci Prog 92:241-87. 2009..b>Lactose intolerance causes gut and a range of systemic symptoms, though the threshold to lactose varies considerably between ..
- Perceived milk intolerance is related to bone mineral content in 10- to 13-year-old female adolescentsLeann Matlik
Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana, USA
Pediatrics 120:e669-77. 2007..The purpose of this study was to determine associations among lactose maldigestion status, perceived milk intolerance, dietary calcium intake, and bone mineral content in early adolescent girls...
- Lactose intolerance among severely malnourished children with diarrhoea admitted to the nutrition unit, Mulago hospital, UgandaRichard Nyeko
Department of Paediatrics and Child Health, St Mary s Hospital Lacor, Gulu, Uganda P O Box 180, Gulu, Uganda
BMC Pediatr 10:31. 2010b>Lactose intolerance is a common complication of diarrhoea in infants with malnutrition and a cause of treatment failure...
- Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT -13910C > T mutationRicardo Almon
Family Medicine Research Centre, Department of Clinical Medicine, Orebro University, Sweden
Scand J Gastroenterol 42:165-70. 2007..The aims of this study were to estimate the prevalence of AtH by genotyping and to investigate whether AtH prevalence has changed in Sweden during the 20th century...
- Genotyping of the lactase-phlorizin hydrolase -13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intoleranceGerd Bodlaj
Institute of Laboratory Medicine, General Hospital Linz, Linz, Austria
Clin Chem 52:148-51. 2006Hypolactasia and lactose intolerance are common conditions worldwide. Hypolactasia seems to be strongly correlated with genotype C/C of the genetic variant C-->T(-13910) upstream of the lactase phlorizin hydrolase (LPH) gene...
- Lactose intolerance associated with adjuvant 5-fluorouracil-based chemotherapy for colorectal cancerPia Osterlund
Department of Oncology, Helsinki University Central Hospital, Finland
Clin Gastroenterol Hepatol 2:696-703. 2004Bowel mucosal injury associated with 5-fluorouracil (5-FU) treatment might result in secondary lactose intolerance. The frequency and clinical significance of 5-FU-related hypolactasia are unknown.
- Gene-culture coevolution between cattle milk protein genes and human lactase genesAlbano Beja-Pereira
Laboratoire d Ecologie Alpine, Génomique des Populations et Biodiversité, CNRS UMR 5553, Universite Joseph Fourier, B P 53, 38041 Grenoble, Cedex 9, France
Nat Genet 35:311-3. 2003..This suggests a gene-culture coevolution between cattle and humans...
- Lactose intolerance symptoms assessed by meta-analysis: a grain of truth that leads to exaggerationDennis A Savaiano
Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana, USA
J Nutr 136:1107-13. 2006A meta-analysis was conducted to compare the lactose intolerance symptoms of lactose maldigesters after consuming lactose (as milk, lactose dissolved in water, milk products, or commercial product) with responses after a placebo under ..
- Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic groupCatherine J E Ingram
Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
J Mol Evol 69:579-88. 2009..This contrasts with the well-documented observation that positive selection decreases diversity by driving up the frequency of a single advantageous allele, and has implications for association studies...
- The molecular basis of lactose intoleranceAnthony K Campbell
Department of Medical Biochemistry and Immunology, Wales College of Medicine, Cardiff University, Cardiff CF14 XN, UK
Sci Prog 88:157-202. 2005..b>Lactose intolerance causes gut and a range of systemic symptoms, though the threshold to lactose varies considerably between ..
- Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west RussiaYulia Khabarova
Department of Family Medicine, Northern State Medical University, Arkhangelsk, Russia
World J Gastroenterol 15:1849-53. 2009..To estimate the prevalence of the lactase non-persistent genotype (C/C-13910) in a northern Russian population in accordance with ethnicity, and to evaluate self-reported milk consumption depending on lactase activity...
- Systematic review: effective management strategies for lactose intoleranceAasma Shaukat
University of Minnesota and Minneapolis Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55471, USA
Ann Intern Med 152:797-803. 2010b>Lactose intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and management of this condition remain unclear.
- Molecularly defined lactose malabsorption, peak bone mass and bone turnover rate in young finnish menN Enattah
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Calcif Tissue Int 75:488-93. 2004..Moreover, the C/C-13910 genotype does not seem to be a risk factor for stress fractures in army recruits...
- Correlation between lactose absorption and the C/T-13910 and G/A-22018 mutations of the lactase-phlorizin hydrolase (LCT) gene in adult-type hypolactasiaA C Bulhões
Laboratório Experimental de Gastroenterologia e Hepatologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
Braz J Med Biol Res 40:1441-6. 2007....
- Screening of variants for lactase persistence/non-persistence in populations from South Africa and GhanaSuvi Torniainen
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
BMC Genet 10:31. 2009....
- A genetic test which can be used to diagnose adult-type hypolactasia in childrenH Rasinpera
HospGenetics, University of Helsinki, Finland
Gut 53:1571-6. 2004..lactose malabsorption) affects most of world's human population and limits the use of fresh milk due to lactose intolerance. The diagnosis of adult-type hypolactasia has been difficult to establish because of unsatisfactory ..
- Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary IslandsRicardo Almon
Family Medicine Research Centre, Orebro University, Sweden
Eur J Nutr 49:141-6. 2010..The single nucleotide polymorphism (SNP) LCT -13910 C>T, associated with genetically determined phenotypes of lactase persistence (LP) or non-persistence (LNP), was studied in relation to the metabolic syndrome (MS)...
- Lactase non-persistence and milk consumption in EstoniaMargus Lember
Department of Internal Medicine, University of Tartu, Estonia
World J Gastroenterol 12:7329-31. 2006..To define the frequency of the C/T-13910 variant associated with lactase persistence/non-persistence trait and to analyze the milk consumption of lactase non-persistent subjects in Estonia...
- Diagnosis, symptoms, and calcium intakes of individuals with self-reported lactose intoleranceHeather Y Lovelace
University of British Columbia, 2205 East Mall, Vancouver, B C, Canada V6T 1Z4
J Am Coll Nutr 24:51-7. 2005To determine methods of diagnosis, symptoms, and calcium intake from food and supplements for individuals with self-reported lactose intolerance.
- Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal womenN Enattah
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Eur J Clin Nutr 59:1105-11. 2005To study the relationships of molecularly defined lactose malabsorption (LM) and self-reported lactose intolerance (LI) to bone mineral density (BMD) and fractures among Finnish postmenopausal women.
- Molecular diagnosis of adult-type hypolactasia (lactase non-persistence)I E Jarvela
Laboratory of Molecular Genetics, Helsinki University Central Hospital and Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Scand J Clin Lab Invest 65:535-9. 2005
- T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitroRikke H Lewinsky
Department of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Denmark
Hum Mol Genet 14:3945-53. 2005..Lactase non-persistence (adult-type hypolactasia and lactose intolerance) is characterized by a decline in the expression of lactase-phlorizin hydrolase (LPH) after weaning...
- Evolutionary genetics: genetics of lactase persistence--fresh lessons in the history of milk drinkingEdward Hollox
Eur J Hum Genet 13:267-9. 2005
- Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humansNabil Sabri Enattah
Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
Am J Hum Genet 81:615-25. 2007....
- Subjective lactose intolerance in apparently healthy adults in southern Iran: Is it related to irritable bowel syndrome?M Saberi-Firoozi
Department of Internal Medicine, Gastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Indian J Med Sci 61:591-7. 2007The main symptoms of lactose intolerance are bloating, abdominal cramps, increased flatus and loose watery stools. These symptoms are similar to those of irritable bowel syndrome (IBS), which is a prevalent entity in the community.
- Concordance of genetic and breath tests for lactose intolerance in a tertiary referral centreMarcin Krawczyk
Medical University of Lublin, Poland
J Gastrointestin Liver Dis 17:135-9. 2008..The aim of the study was to compare the results of both tests in detecting lactose non-persistence in a tertiary referral centre...
- Lactose intolerance: a non-allergic disorder often managed by allergologistsA Perino
Ospedale S Luigi, Unversità degli Studi di Torino
Eur Ann Allergy Clin Immunol 41:3-16. 2009..This condition is known as lactose intolerance. Lactase non-persistence is the ancestral state, whilst two single nucleotide polymorphisms in the lactase ..
- Impact of molecularly defined hypolactasia, self-perceived milk intolerance and milk consumption on bone mineral density in a population sample in Northern EuropeMart Kull
Department of Internal Medicine, University of Tartu, Tartu, Estonia
Scand J Gastroenterol 44:415-21. 2009..Low lactase activity in adult-type hypolactasia (HL) and self-perceived lactose intolerance (LI) are the main limiting factors of milk intake...
- Irritable bowel syndrome: is the search for lactose intolerance justified?T J Parker
Department of Gastroenterology, Addenbrooke s Hospital, Cambridge, UK
Eur J Gastroenterol Hepatol 13:219-25. 2001..To determine if confirmation of hypolactasia offers any benefit to the dietary treatment of patients with irritable bowel syndrome (IBS)...
- Lactose intolerance: problems in diagnosis and treatmentA D Shaw
Nutrition Research Centre, School of Applied Science, South Bank University, London, United Kingdom
J Clin Gastroenterol 28:208-16. 1999..Symptom similarity and the resultant incorrect diagnosis of IBS may explain the refractory nature of some patients labeled as IBS who remain largely unaware of the relationship between food intake and symptoms...
- Lactose maldigestion, calcium intake and osteoporosis in African-, Asian-, and Hispanic-AmericansK A Jackson
Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907-1260, USA
J Am Coll Nutr 20:198S-207S. 2001....
- Lactose intolerance: a self-fulfilling prophecy leading to osteoporosis?Dennis Savaiano
Purdue University, Stone Hall Room 110, 700 W State Street, West Lafayette, IN, 47907 2059, USA
Nutr Rev 61:221-3. 2003Symptoms of lactose intolerance are unlikely to occur under usual dietary conditions. Yet, self-described "lactose-intolerant" individuals often restrict dairy and calcium intake...
- Familial aquagenic urticaria associated with familial lactose intoleranceRegina Treudler
Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Germany
J Am Acad Dermatol 47:611-3. 2002..familial occurrence of aquagenic urticaria over 3 generations is reported here in association with familial lactose intolerance, a condition in which the enzyme lactase encoded on chromosome 2, is deficient...
- Incidence and clinical significance of lactose malabsorption in adult coeliac diseaseS Bode
Dept of Internal Medicine and Gastroenterology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Scand J Gastroenterol 23:484-8. 1988..The lactose activity in a proximal intestinal biopsy specimen was found to be an unreliable indicator of lactose malabsorption in coeliac disease...
- Intolerance to lactose and other dietary sugarsD M Swallow
Medical Research Council Human Biochemical Genetics Unit, Galton Laboratory, Department of Biology, London, United Kingdom
Drug Metab Dispos 29:513-6. 2001..This article reviews this topic and discusses in more detail the current state of our own research on lactase...
- The myth of increased lactose intolerance in African-AmericansKatherine G Byers
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
J Am Coll Nutr 24:569S-73S. 2005In the United States, approximately three fourths of African-Americans have the potential for symptoms of lactose intolerance because lactose digestion depends on the presence of the enzyme lactase-phlorizin hydrolase which is reduced by ..
- Introducing genetic testing for adult-type hypolactasiaCarsten Buning
Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Humboldt University of Berlin, Berlin, Germany
Digestion 71:245-50. 2005To evaluate genotyping for two DNA variants (c.1993+327C>T and c.1438+117G>A), recently found to be associated with adult-type hypolactasia, in the diagnosis of lactose intolerance.
- Lactose intolerance in patients with irritable bowel syndrome from northern India: a case-control studyDinesh Gupta
Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
J Gastroenterol Hepatol 22:2261-5. 2007Symptoms of irritable bowel syndrome (IBS) and lactose intolerance (LI) overlap. Data on the frequency of LI in patients with IBS from India are scanty...
- High prevalence of celiac disease in patients with lactose intoleranceVeronica Ojetti
Internal Medicine, Catholic University, Rome, Italy
Digestion 71:106-10. 2005..Several studies have highlighted the prevalence of lactose intolerance in celiac disease, but studies assessing the prevalence of celiac disease in lactose intolerance are ..
- Lactose intolerance in different types of irritable bowel syndrome in north IndiansS V Rana
Department of Superspeciality of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
Trop Gastroenterol 22:202-4. 2001Twenty-five patients of irritable bowel syndrome (IBS) and 25 normal healthy individuals serving as controls, were studied for lactose intolerance.
- Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiencyMikko Kuokkanen
Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
Am J Hum Genet 78:339-44. 2006..Further, our data demonstrate that, in contrast to common adult-type hypolactasia (lactose intolerance) caused by a variant of the regulatory element, the severe infancy form represents the outcome of mutations ..
- Lactose intoleranceDaniel L Swagerty
Department of Family Medicine, University of Kansas School of Medicine, Kansas City 66160 7370, USA
Am Fam Physician 65:1845-50. 2002Persons with lactose intolerance are unable to digest significant amounts of lactose because of a genetically inadequate amount of the enzyme lactase...
- Lactose intolerance in infants, children, and adolescentsMelvin B Heyman
Pediatrics 118:1279-86. 2006The American Academy of Pediatrics Committee on Nutrition presents an updated review of lactose intolerance in infants, children, and adolescents...
- Single nucleotide polymorphism C/T(-13910), located upstream of the lactase gene, associated with adult-type hypolactasia: validation for clinical practiceRejane Mattar
Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, SP, Brazil
Clin Biochem 41:628-30. 2008..To validate C/T(-13910) polymorphism associated with primary hypolactasia for clinical practice...
- Review article: lactose intolerance in clinical practice--myths and realitiesM C E Lomer
Department of Gastroenterology, Guy s and St Thomas NHS Foundation Trust, London, UK
Aliment Pharmacol Ther 27:93-103. 2008..However, not everyone has lactose intolerance, as several nutritional and genetic factors influence tolerance.
- Correlation between symptoms developed after the oral ingestion of 50 g lactose and results of hydrogen breath testing for lactose intoleranceL Beyerlein
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
Aliment Pharmacol Ther 27:659-65. 2008Lactase deficiency is a common condition responsible for various abdominal symptoms. Lactose hydrogen breath test is currently the gold standard in diagnosing lactose intolerance.
- Do probiotics reduce adult lactose intolerance? A systematic reviewKara M Levri
University of Pittsburgh Medical Center St Margaret, 3937 Butler Street, Pittsburgh, PA 15201, USA
J Fam Pract 54:613-20. 2005To assess the efficacy of oral probiotics in adults with lactose intolerance through a systematic review of its effects on symptoms and breath hydrogen tests, and whether adding probiotics to nonfermented dairy products decreases lactose ..
- Absence of the lactase-persistence-associated allele in early Neolithic EuropeansJ Burger
Johannes Gutenberg University, Institute of Anthropology, Saarstrasse 21, D 55099 Mainz, Germany
Proc Natl Acad Sci U S A 104:3736-41. 2007..We did not observe the allele most commonly associated with LP in Europeans, thus providing evidence for the culture-historical hypothesis, and indicating that LP was rare in early European farmers...
- Visceral hypersensitivity and intolerance symptoms in lactose malabsorptionM Di Stefano
Department of Medicine, IRCCS S Matteo Hospital, University of Pavia, Pavia, Italy
Neurogastroenterol Motil 19:887-95. 2007..functional symptoms, we evaluated whether an alteration of visceral sensitivity is present in subjects with lactose intolerance. Thirty subjects, recruited regardless of whether they were aware of their capacity to absorb lactose, ..
- Lactose intolerance: lactose tolerance test versus genotypingPeter Ridefelt
Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
Scand J Gastroenterol 40:822-6. 2005Adult lactose intolerance, which affects the majority of the population in the world, has been associated with a single nucleotide polymorphism, C-13910T, located upstream of the lactase gene.
- Overcoming the barrier of lactose intolerance to reduce health disparitiesJudith K Jarvis
National Dairy Council, Rosemont, Illinois 60018 5616 USA
J Natl Med Assoc 94:55-66. 2002..Although lactose intolerance may be partly to blame for the low calcium intakes due to reduced dairy food consumption by minority ..
- Genetics of lactase persistence and lactose intoleranceDallas M Swallow
Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, England
Annu Rev Genet 37:197-219. 2003..This single nucleotide polymorphism is located 14 kb upstream from the start of transcription of lactase in an intron of the adjacent gene MCM6. This change does not, however, explain all the variation in lactase expression...
- The relationship between lactose tolerance test results and symptoms of lactose intoleranceM M Hermans
Department of Gastroenterology, University Hospital Maastricht, The Netherlands
Am J Gastroenterol 92:981-4. 1997..In this study, we have tried to elucidate the relationship between lactose tolerance test results and symptoms after a lactose challenge. This relationship might be an indicator for the validity of the test...
- An upstream polymorphism associated with lactase persistence has increased enhancer activityJesper T Troelsen
Department of Medical Biochemistry and Genetics, Biochemical Laboratory C, The Panum Institute, University of Copenhagen, Denmark
Gastroenterology 125:1686-94. 2003..The aim of this study was to investigate the role of these nucleotide polymorphisms for lactase-phlorizin hydrolase (LPH) gene expression...
- Assignment of the locus for congenital lactase deficiency to 2q21, in the vicinity of but separate from the lactase-phlorizin hydrolase geneI Jarvela
Department of Human Molecular Genetics, National Public Health Institute, Finland
Am J Hum Genet 63:1078-85. 1998..Surprisingly, the LPH gene was shown to lie outside the critical CLD region, excluding it as a causative gene for CLD. The LPH locus was found to reside >2 Mb from the critical CLD region...
- Evaluation of a new DNA test compared with the lactose hydrogen breath test for the diagnosis of lactase non-persistenceChristoph Hogenauer
Department of Internal Medicine, Medical University of Graz, Austria
Eur J Gastroenterol Hepatol 17:371-6. 2005..We therefore compared the value of DNA testing for this variant (DNA test) with the lactose hydrogen breath test (H2 test), which is the clinical standard for the diagnosis of lactase non-persistence...
- Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory elementLynne C Olds
Department of Pediatrics, Stanford University School of Medicine, 750 Welch Road, Suite 116, Palo Alto, CA 94305, USA
Hum Mol Genet 12:2333-40. 2003..Such differential regulation by the C and T variants is consistent with a causative role in the mechanism specifying the lactase persistence/non-persistence phenotypes in humans...
- Maturational Regulation of Lactase Gene TranscriptionEric Sibley; Fiscal Year: 2002....
- Metabolic consequences of sickle cell anemiaMaciej Buchowski; Fiscal Year: 2005..abstract_text> ..
- Safe and Effective Vitamin D Supplementation in HIVVirginia A Stallings; Fiscal Year: 2012..Poor vit D status is common in HIV/AIDS patients of all ages and factors such as age, skin pigment, lactose intolerance, and sun exposure alter the risks for vit D deficiency. In the multicenter U.S...
- Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent WeightJoan Lappe; Fiscal Year: 2012..Exclusion criteria include: total body bone mineral content (TBBMC) Z score <-2;pregnancy, lactose intolerance, early menarche, or any health problem...
- A Transcutaneous Gas Sensor for Noninvasive Diagnosis of Necrotizing EnterocolitiOOMMAN VARGHESE; Fiscal Year: 2009..of a titania nanotube-based hydrogen sensor to monitor transcutaneous hydrogen levels for predicting lactose intolerance in volunteer patients...
- Fold Specific & Entropic AdaptationNicholas Panasik; Fiscal Year: 2009DESCRIPTION (provided by applicant): Lactose Intolerance is an increasingly prevalent malady that affects 20% of the American population, 90% of African Americans, 95% of Asian Americans, and 99% of Native Americans...
- BUILDING BETTER BONES IN CHILDRENBabette Zemel; Fiscal Year: 2003..risk factors for low bone density (previous fracture from usual childhood activities, daily refusal, or lactose intolerance, family history of osteoporosis)...
- PRODUCING LACTOLYZED MILK AND WHEY BY MONOLITHIC SUPPORTABDUL MAZID; Fiscal Year: 1999..Because of widespread lactose intolerance, it is of utmost importance to have inexpensive processes for preparing dairy foods in which lactose is ..
- Characterization of the P5 Subfamily of P-type Transport ATPases in MicePATRICK SCHULTHEIS; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IVRichard B Weinberg; Fiscal Year: 2010..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..
- Magnesium Deficiency: Global Gene Expression StudyPATRICK SCHULTHEIS; Fiscal Year: 2002..This combination of techniques should lead to the identification of all genes that are differentially expressed during magnesium deficiency. ..
- Physical Activity Energy Expenditure and Adolescent ObesityMaciej Buchowski; Fiscal Year: 2007..abstract_text> ..
- MODELING DNA DIVERSITY IN CARDIOVASCULAR HEALTH/DISEASEKenneth Weiss; Fiscal Year: 2001..These studies will provide an unprecedented ..
- Epidemiology of Celiac Disease: A Population Based StudyJoseph A Murray; Fiscal Year: 2010..This will provide crucial data that will determine the need for early detection by screening and treatment of silent celiac disease, which may affect 1% of Americans. ..
- A HLA Mouse Model for Gluten Sensitivity and EnteropathyJoseph Murray; Fiscal Year: 2009..abstract_text> ..
- Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary EmbolismCarlos Camargo; Fiscal Year: 2008..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
- A novel approach to predict energy of physical activityMaciej Buchowski; Fiscal Year: 2008..In addition, our study will improve and validate EEAcT prediction by several market-available PA monitors, thus offering immediate benefits to their applications in the field. ..
- DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASECarlos Camargo; Fiscal Year: 2002..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
- DEVELOPMENTAL REGULATION OF LACTASE GENE TRANSCRIPTIONEric Sibley; Fiscal Year: 2003....
- Neonatal Nutrition and the Genetics of Human LactationRichard Weinberg; Fiscal Year: 2003..This knowledge could eventually enable the identification of women who require specific fatty acid or vitamin supplementation to assure optimal infant nutrition. ..
- Neuropharmacology of Learned Food PreferencesAnthony Sclafani; Fiscal Year: 2009..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..