lactose intolerance

Summary

Summary: The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.

Top Publications

  1. ncbi Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures
    Barbara M Obermayer-Pietsch
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Karl Franzens University Hospital, Graz, Austria
    J Bone Miner Res 19:42-7. 2004
  2. ncbi The effects of adult-type hypolactasia on body height growth and dietary calcium intake from childhood into young adulthood: a 21-year follow-up study--the Cardiovascular Risk in Young Finns Study
    Terho Lehtimaki
    Department of Clinical Chemistry, Tampere University Hospital, PO Box 2000, FI33521 Tampere, Finland
    Pediatrics 118:1553-9. 2006
  3. ncbi Association of lactose sensitivity with inflammatory bowel disease--demonstrated by analysis of genetic polymorphism, breath gases and symptoms
    P Eadala
    Department of Gastroenterology, Morriston Hospital, Swansea, UK
    Aliment Pharmacol Ther 34:735-46. 2011
  4. ncbi Identification of a variant associated with adult-type hypolactasia
    Nabil Sabri Enattah
    Department of Molecular Medicine, National Public Health Institute, Haartmaninkatu 8, PO Box 104, Fin 00251 Helsinki, Finland
    Nat Genet 30:233-7. 2002
  5. ncbi Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndrome
    A K Campbell
    Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF103NB, UK
    Toxicology 278:268-76. 2010
  6. ncbi NIH consensus development conference statement: Lactose intolerance and health
    Frederick J Suchy
    Jack and Lucy Clark Department of Pediatrics, Mount Sinai School of Medicine of New York University, Mount Sinai Kravis Children s Hospital, New York, New York, USA
    NIH Consens State Sci Statements 27:1-27. 2010
  7. ncbi Colonic fermentation may play a role in lactose intolerance in humans
    Tao He
    Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Nutr 136:58-63. 2006
  8. ncbi Prevalence and presentation of lactose intolerance and effects on dairy product intake in healthy subjects and patients with irritable bowel syndrome
    Jianfeng Yang
    Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
    Clin Gastroenterol Hepatol 11:262-268.e1. 2013
  9. ncbi [Molecular diagnosis and frequencies of primary hypolactasia in populations of RUSSIA and neighboring countries]
    S A Borinskaia
    Mol Biol (Mosk) 40:1031-6. 2006
  10. ncbi Methods and functions: Breath tests
    Barbara Braden
    John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
    Best Pract Res Clin Gastroenterol 23:337-52. 2009

Detail Information

Publications266 found, 100 shown here

  1. ncbi Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures
    Barbara M Obermayer-Pietsch
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Karl Franzens University Hospital, Graz, Austria
    J Bone Miner Res 19:42-7. 2004
    Evidence that genetic disposition for adult lactose intolerance significantly affects calcium intake, bone density, and fractures in postmenopausal women is presented...
  2. ncbi The effects of adult-type hypolactasia on body height growth and dietary calcium intake from childhood into young adulthood: a 21-year follow-up study--the Cardiovascular Risk in Young Finns Study
    Terho Lehtimaki
    Department of Clinical Chemistry, Tampere University Hospital, PO Box 2000, FI33521 Tampere, Finland
    Pediatrics 118:1553-9. 2006
    ..We studied whether this polymorphism was associated with body height growth, the use of milk products, or dietary calcium intake...
  3. ncbi Association of lactose sensitivity with inflammatory bowel disease--demonstrated by analysis of genetic polymorphism, breath gases and symptoms
    P Eadala
    Department of Gastroenterology, Morriston Hospital, Swansea, UK
    Aliment Pharmacol Ther 34:735-46. 2011
    ..The genetic marker CC₁₃₉₁₀, on chromosome2, with measurement of breath hydrogen and methane, and gut and systemic symptoms, are now the most comprehensive tests for evaluating sensitivity to lactose...
  4. ncbi Identification of a variant associated with adult-type hypolactasia
    Nabil Sabri Enattah
    Department of Molecular Medicine, National Public Health Institute, Haartmaninkatu 8, PO Box 104, Fin 00251 Helsinki, Finland
    Nat Genet 30:233-7. 2002
    Adult-type hypolactasia, also known as lactase non-persistence (lactose intolerance), is a common autosomal recessive condition resulting from the physiological decline in activity of the lactase-phlorizin hydrolase (LPH) in intestinal ..
  5. ncbi Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndrome
    A K Campbell
    Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF103NB, UK
    Toxicology 278:268-76. 2010
    ..We propose it will lead to a new understanding of the molecular mechanism of type 2 diabetes and some cancers...
  6. ncbi NIH consensus development conference statement: Lactose intolerance and health
    Frederick J Suchy
    Jack and Lucy Clark Department of Pediatrics, Mount Sinai School of Medicine of New York University, Mount Sinai Kravis Children s Hospital, New York, New York, USA
    NIH Consens State Sci Statements 27:1-27. 2010
    To provide health care providers, patients, and the general public with a responsible assessment of currently available data on lactose intolerance and health.
  7. ncbi Colonic fermentation may play a role in lactose intolerance in humans
    Tao He
    Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Nutr 136:58-63. 2006
    ..to the small intestinal lactase activity and transit time, colonic processing of lactose may play a role in lactose intolerance. We investigated whether colonic fermentation of lactose is correlated with lactose intolerance...
  8. ncbi Prevalence and presentation of lactose intolerance and effects on dairy product intake in healthy subjects and patients with irritable bowel syndrome
    Jianfeng Yang
    Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
    Clin Gastroenterol Hepatol 11:262-268.e1. 2013
    ..We assessed lactose absorption and tolerance and the intake of dairy products in healthy volunteers (controls) and patients with diarrhea-predominant IBS (D-IBS)...
  9. ncbi [Molecular diagnosis and frequencies of primary hypolactasia in populations of RUSSIA and neighboring countries]
    S A Borinskaia
    Mol Biol (Mosk) 40:1031-6. 2006
    ..Practical application of this type of diagnostics would be a step towards the individual-oriented medicine...
  10. ncbi Methods and functions: Breath tests
    Barbara Braden
    John Radcliffe Hospital, Headley Way, OX3 9DU Oxford, UK
    Best Pract Res Clin Gastroenterol 23:337-52. 2009
    ..The knowledge of potential pitfalls and influencing factors are important for correct interpretation of breath test results before drawing clinical conclusions...
  11. pmc Systemic lactose intolerance: a new perspective on an old problem
    S B Matthews
    Department of Medical Biochemistry and Immunology, Llandough Hospital, Cardiff and Vale NHS Trust, Penarth Vale of Glamorgan, UK
    Postgrad Med J 81:167-73. 2005
    ..symptoms and a six hour breath hydrogen test, provides a new approach to the clinical management of lactose intolerance. The key is the prolonged effect of dietary removal of lactose...
  12. ncbi Benefits of breath hydrogen testing after lactulose administration in analysing carbohydrate malabsorption
    John P Bate
    Departments of Medicine and Gastroenterology, Monash University, Box Hill Hospital, Box Hill, Victoria, Australia
    Eur J Gastroenterol Hepatol 22:318-26. 2010
    ..We examined the contribution of breath testing after lactulose administration to the conduct and interpretation of breath hydrogen responses after fructose and lactose administration...
  13. ncbi Improved parameters of lactose maldigestion using lactulose
    A Szilagyi
    Department of Medicine, The Sir Mortimer B. Davis Jewish General Hospital Faculty of Medicine, McGill University Montreal, Quebec, Canada
    Dig Dis Sci 46:1509-19. 2001
    ..Fecal beta-galactosidase significantly increased after lactulose. This study supports the notion that lactulose and lactose may have similar clinical effects...
  14. ncbi Sugar malabsorption in functional abdominal bloating: a pilot study on the long-term effect of dietary treatment
    Fernando Fernández-Bañares
    Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Plaza Dr Robert 5, 08221 Terrassa, Barcelona, Spain
    Clin Nutr 25:824-31. 2006
    ..Gas-related complaints (i.e., passage of flatus), which are present in a subgroup of these patients, might be associated with carbohydrate malabsorption...
  15. ncbi Lactose malabsorption and intolerance and peak bone mass
    Michele Di Stefano
    Gastroenterology Unit, IRCCS S Matteo Hospital, University of Pavia, Pavia, Italy
    Gastroenterology 122:1793-9. 2002
    ..The purpose of this study was to evaluate whether lactose intolerance interferes with the achievement of an adequate peak bone mass in young adults.
  16. ncbi Lactose intolerance in patients with chronic functional diarrhoea: the role of small intestinal bacterial overgrowth
    J Zhao
    Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Aliment Pharmacol Ther 31:892-900. 2010
    Many studies report a high prevalence of lactose intolerance in patients with functional, gastrointestinal disease.
  17. ncbi A novel acid-stable, acid-active beta-galactosidase potentially suited to the alleviation of lactose intolerance
    Shane O'Connell
    Shannon Applied Biotechnology Centre, IT Tralee, Tralee, Co Kerry, Ireland
    Appl Microbiol Biotechnol 86:517-24. 2010
    ..5-fold more lactose than did the commercial supplemental enzyme. The acid-stable, acid-active enzyme, along with the novel two-segment delivery system, may prove beneficial in the more effective treatment of lactose intolerance.
  18. ncbi A randomized trial of Lactobacillus acidophilus BG2FO4 to treat lactose intolerance
    J R Saltzman
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and the Tufts University School of Medicine, Boston, USA
    Am J Clin Nutr 69:140-6. 1999
    b>Lactose intolerance is the most common disorder of intestinal carbohydrate digestion. Lactobacillus acidophilus BG2FO4 is a strain of lactobacilli with properties of marked intestinal adherence and high beta-galactosidase activity.
  19. ncbi Milk consumption and lactose intolerance in adults
    Rong Qiao
    Department of Nutrition and Food Safety, Sichuan University, Chengdu 610041, Sichuan, China
    Biomed Environ Sci 24:512-7. 2011
    To investigate relations between milk consumption and lactose intolerance (LI) in adults and to explore the effect of milk consumption on lactase activity.
  20. ncbi Lactose malabsorption, calcium intake, and bone mass in children and adolescents
    Lilian C da Silva Medeiros
    Department of Nutrition, Federal University of Sao Paulo, Brazil
    J Pediatr Gastroenterol Nutr 54:204-9. 2012
    ..The objective of the present study was to evaluate the calcium intake and bone mass in children and early adolescents in accordance with their absorption capacity to lactose...
  21. pmc Differential impact of lactose/lactase phenotype on colonic microflora
    Andrew Szilagyi
    Division of Gastroenterology, Department of Medicine, McGill School of Medicine, Montreal, Quebec
    Can J Gastroenterol 24:373-9. 2010
    ..Prebiotic effects likely favour lactose maldigesters who experience lactose spilling into their colon...
  22. pmc Lactose intolerance: lack of evidence for short stature or vitamin D deficiency in prepubertal children
    Nithya Setty-Shah
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 8:e78653. 2013
    The health consequences of lactose intolerance (LI) are unclear.
  23. ncbi Application relevant studies of fungal beta-galactosidases with potential application in the alleviation of lactose intolerance
    S O'Connell
    Department of Chemical and Environmental Sciences and Materials and Surface Sciences Institute, University of Limerick, Limerick City, Ireland
    Appl Biochem Biotechnol 149:129-38. 2008
    ..activity potentially suited for use as a lactase digestive supplement in the treatment of lactose intolerance. The crude preparation contained two beta-galactosidase activities, beta-gal 1 and beta-gal 2, which were ..
  24. pmc Fructose and lactose intolerance and malabsorption testing: the relationship with symptoms in functional gastrointestinal disorders
    C H Wilder-Smith
    Gastroenterology Group Practice, Brain Gut Research Group, Bern, Switzerland
    Aliment Pharmacol Ther 37:1074-83. 2013
    The association of fructose and lactose intolerance and malabsorption with the symptoms of different functional gastrointestinal disorders (FGID) remains unclear.
  25. ncbi Does lactose intolerance predispose to low bone density? A population-based study of perimenopausal Finnish women
    R Honkanen
    Institute of Community Medicine, University of Tromsø, Norway
    Bone 19:23-8. 1996
    ..We examined the relationship of self-reported lactose intolerance (LI) to bone mineral density (BMD) in perimenopausal Finnish women...
  26. ncbi Lactose intolerance: analysis of underlying factors
    R J Vonk
    Laboratory Nutrition and Metabolism, Laboratory Centre CMC V, Y2147, University Hospital Groningen, PO Box 30 001, 9700 Groningen, The Netherlands
    Eur J Clin Invest 33:70-5. 2003
    We studied the degree of lactose digestion and orocecal transit time (OCTT) as possible causes for the variability of symptoms of lactose intolerance (LI) in a sample of a population with genetically determined low lactase activity.
  27. ncbi Peroral gene therapy of lactose intolerance using an adeno-associated virus vector
    M J During
    Department of Molecular Medicine, University of Auckland School of Medicine, New Zealand
    Nat Med 4:1131-5. 1998
    ..lamina propria cells, and that this approach results in long-term phenotypic recovery in an animal model of lactose intolerance. A gene 'pill' associated with highly efficient and stable gene expression might be a practical and cost-..
  28. pmc Consensus report of the National Medical Association. The role of dairy and dairy nutrients in the diet of African Americans
    Wilma J Wooten
    National Medical Association, Women Section, San Diego, CA, USA
    J Natl Med Assoc 96:5S-31S. 2004
  29. ncbi Fermentation, fermented foods and lactose intolerance
    N W Solomons
    Center for Studies of Sensory Impairment, Aging and Metabolism CeSSIAM, Guatemala City, Guatemala
    Eur J Clin Nutr 56:S50-5. 2002
    ..In this way, the issues of lactose intolerance and of fermented foods are joined...
  30. ncbi [Effect of probiotics and yogurt on colonic microflora in subjects with lactose intolerance]
    Yan Zhong
    Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China
    Wei Sheng Yan Jiu 35:587-91. 2006
    To study the effects of probiotics and yoghurt supplementation on colonic microflora in subjects with lactose intolerance (LI).
  31. ncbi The role of colonic metabolism in lactose intolerance
    T He
    TI Food and Nutrition, Wageningen, The Netherlands
    Eur J Clin Invest 38:541-7. 2008
    Lactose maldigestion and intolerance affect a large part of the world population. The underlying factors of lactose intolerance are not fully understood. In this review, the role of colonic metabolism is discussed, i.e...
  32. ncbi A re-appraisal of lactose intolerance
    L K Harrington
    Department of Gastroenterology, Leicester General Hospital, Leicester, UK
    Int J Clin Pract 62:1541-6. 2008
    Lactose, beta-galactose-1,4-glucose, is hydrolysed by the enzyme lactase. Lactose intolerance occurs when lactase deficiency causes clinical symptoms.
  33. ncbi Lactose intolerance revealed by severe resistance to treatment with levothyroxine
    Manuel Muñoz-Torres
    Department of Endocrinology, Hospital Universitario San Cecilio de Granada, Granada, Spain
    Thyroid 16:1171-3. 2006
    ..The incidence of lactose intolerance in Caucasian adult patients is 7%-20%, but the association with resistance to treatment with oral LT(4) is ..
  34. ncbi Self-perceived lactose intolerance results in lower intakes of calcium and dairy foods and is associated with hypertension and diabetes in adults
    Theresa A Nicklas
    US Department of Agriculture Agricultural Research Service, Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Clin Nutr 94:191-8. 2011
    Self-perceived lactose intolerance may result in adverse dietary modifications; thus, more studies are needed to understand the prevalence of self-perceived lactose intolerance and how it relates to calcium intake and selected health ..
  35. ncbi A novel method for diagnosis of adult hypolactasia by genotyping of the -13910 C/T polymorphism with Pyrosequencing technology
    T K Nilsson
    Dept of Clinical Chemistry and the Clinical Research Center, Orebro University Hospital, Orebro, Sweden
    Scand J Gastroenterol 39:287-90. 2004
    ....
  36. ncbi Lactose digestion and the evolutionary genetics of lactase persistence
    Catherine J E Ingram
    Department of Genetics Evolution and Environment, University College London, London, UK
    Hum Genet 124:579-91. 2009
    ....
  37. ncbi [Frequency of bacterial overgrowth in patients with clinical lactose intolerance]
    Abel Novillo
    Departamento de Medicina, Sección Gastroenterología, CEMIC Centro de Educaciín Mèdica e Investigaciones Clínicas, Buenos Aires, Argentina
    Acta Gastroenterol Latinoam 40:221-4. 2010
    ..This intolerance could be associated with an intestinal bacterial overgrowth or an increased fermentative intestinal profile and not due to lactose malabsorption...
  38. ncbi The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity
    Tine G K Jensen
    Department of Cellular and Molecular Medicine, Panum Institute, Building 6 4, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen N, Denmark
    Hum Genet 130:483-93. 2011
    ..Binding sites for Oct-1 and HNF1α surrounding the -14010 position were identified by gel shift assays, which indicated that -14010*C has greater binding affinity to Oct-1 than -14010*G...
  39. pmc High frequency of lactose intolerance in a prehistoric hunter-gatherer population in northern Europe
    Helena Malmström
    Department of Evolutionary Biology, Uppsala University, 752 36 Uppsala, Sweden
    BMC Evol Biol 10:89. 2010
    ..This genetic trait is believed to have evolved within a short time period and to be related with the emergence of sedentary agriculture...
  40. ncbi Subjective perception of lactose intolerance does not always indicate lactose malabsorption
    Francesc Casellas
    Digestive System Research Unit, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Clin Gastroenterol Hepatol 8:581-6. 2010
    Symptomatic lactose intolerance is common; however, abdominal symptoms that patients experience after ingestion of lactose-containing foods can have causes beyond lactose malabsorption...
  41. ncbi Diagnosis of lactose intolerance and the "nocebo" effect: the role of negative expectations
    Piero Vernia
    Gastroenterologia A, Dipartimento di Scienze Cliniche, Sapienza Universita di Roma, Viale del Policlinico, 00161 Roma, Italy
    Dig Liver Dis 42:616-9. 2010
    Diagnosis of lactose intolerance is based on a "positive" H(2) breath test associated with abdominal symptoms...
  42. ncbi Lactose intolerance in active Crohn's disease: clinical value of duodenal lactase analysis
    Christian Von Tirpitz
    Department of Medicine I, University of Ulm, Ulm, Germany
    J Clin Gastroenterol 34:49-53. 2002
    ..Patients with active Crohn's disease (CD) often report having abdominal symptoms after ingestion of milk products, but the pathomechanism for lactose malabsorption seems to be complex...
  43. ncbi Lactose malabsorption in Khants in western Siberia
    M Lember
    University of Tartu, Estonia
    Scand J Gastroenterol 30:225-7. 1995
    ..We wanted to estimate the prevalence of selective lactose malabsorption (SLM) in Khants, a small Finno-Ugric population living in Western Siberia who have traditionally consumed no milk in adulthood...
  44. ncbi Lactose intolerance in infants with gluten-sensitive enteropathy: frequency and clinical characteristics
    Nedeljko Radlovic
    University Children s Hospital, Belgrade, Serbia
    Srp Arh Celok Lek 137:33-7. 2009
    Secondary lactose intolerance (SLI) belongs to the rarer manifestations of gluten-sensitive enteropathy (GSE). It occurs in more severe forms of the disease and its presence contributes significantly to the degree of its expression.
  45. ncbi The molecular basis of lactose intolerance
    Anthony K Campbell
    Department of Medical Biochemistry and Immunology, Wales College of Medicine, Cardiff University, Cardiff, CF14 XN, UK
    Sci Prog 92:241-87. 2009
    ..b>Lactose intolerance causes gut and a range of systemic symptoms, though the threshold to lactose varies considerably between ..
  46. ncbi Perceived milk intolerance is related to bone mineral content in 10- to 13-year-old female adolescents
    Leann Matlik
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana, USA
    Pediatrics 120:e669-77. 2007
    ..The purpose of this study was to determine associations among lactose maldigestion status, perceived milk intolerance, dietary calcium intake, and bone mineral content in early adolescent girls...
  47. pmc Lactose intolerance among severely malnourished children with diarrhoea admitted to the nutrition unit, Mulago hospital, Uganda
    Richard Nyeko
    Department of Paediatrics and Child Health, St Mary s Hospital Lacor, Gulu, Uganda P O Box 180, Gulu, Uganda
    BMC Pediatr 10:31. 2010
    b>Lactose intolerance is a common complication of diarrhoea in infants with malnutrition and a cause of treatment failure...
  48. ncbi Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT -13910C > T mutation
    Ricardo Almon
    Family Medicine Research Centre, Department of Clinical Medicine, Orebro University, Sweden
    Scand J Gastroenterol 42:165-70. 2007
    ..The aims of this study were to estimate the prevalence of AtH by genotyping and to investigate whether AtH prevalence has changed in Sweden during the 20th century...
  49. ncbi Genotyping of the lactase-phlorizin hydrolase -13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance
    Gerd Bodlaj
    Institute of Laboratory Medicine, General Hospital Linz, Linz, Austria
    Clin Chem 52:148-51. 2006
    Hypolactasia and lactose intolerance are common conditions worldwide. Hypolactasia seems to be strongly correlated with genotype C/C of the genetic variant C-->T(-13910) upstream of the lactase phlorizin hydrolase (LPH) gene...
  50. ncbi Lactose intolerance associated with adjuvant 5-fluorouracil-based chemotherapy for colorectal cancer
    Pia Osterlund
    Department of Oncology, Helsinki University Central Hospital, Finland
    Clin Gastroenterol Hepatol 2:696-703. 2004
    Bowel mucosal injury associated with 5-fluorouracil (5-FU) treatment might result in secondary lactose intolerance. The frequency and clinical significance of 5-FU-related hypolactasia are unknown.
  51. ncbi Gene-culture coevolution between cattle milk protein genes and human lactase genes
    Albano Beja-Pereira
    Laboratoire d Ecologie Alpine, Génomique des Populations et Biodiversité, CNRS UMR 5553, Universite Joseph Fourier, B P 53, 38041 Grenoble, Cedex 9, France
    Nat Genet 35:311-3. 2003
    ..This suggests a gene-culture coevolution between cattle and humans...
  52. ncbi Lactose intolerance symptoms assessed by meta-analysis: a grain of truth that leads to exaggeration
    Dennis A Savaiano
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana, USA
    J Nutr 136:1107-13. 2006
    A meta-analysis was conducted to compare the lactose intolerance symptoms of lactose maldigesters after consuming lactose (as milk, lactose dissolved in water, milk products, or commercial product) with responses after a placebo under ..
  53. ncbi Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group
    Catherine J E Ingram
    Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    J Mol Evol 69:579-88. 2009
    ..This contrasts with the well-documented observation that positive selection decreases diversity by driving up the frequency of a single advantageous allele, and has implications for association studies...
  54. ncbi The molecular basis of lactose intolerance
    Anthony K Campbell
    Department of Medical Biochemistry and Immunology, Wales College of Medicine, Cardiff University, Cardiff CF14 XN, UK
    Sci Prog 88:157-202. 2005
    ..b>Lactose intolerance causes gut and a range of systemic symptoms, though the threshold to lactose varies considerably between ..
  55. pmc Prevalence of lactase persistent/non-persistent genotypes and milk consumption in a young population in north-west Russia
    Yulia Khabarova
    Department of Family Medicine, Northern State Medical University, Arkhangelsk, Russia
    World J Gastroenterol 15:1849-53. 2009
    ..To estimate the prevalence of the lactase non-persistent genotype (C/C-13910) in a northern Russian population in accordance with ethnicity, and to evaluate self-reported milk consumption depending on lactase activity...
  56. ncbi Systematic review: effective management strategies for lactose intolerance
    Aasma Shaukat
    University of Minnesota and Minneapolis Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55471, USA
    Ann Intern Med 152:797-803. 2010
    b>Lactose intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and management of this condition remain unclear.
  57. ncbi Molecularly defined lactose malabsorption, peak bone mass and bone turnover rate in young finnish men
    N Enattah
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Calcif Tissue Int 75:488-93. 2004
    ..Moreover, the C/C-13910 genotype does not seem to be a risk factor for stress fractures in army recruits...
  58. ncbi Correlation between lactose absorption and the C/T-13910 and G/A-22018 mutations of the lactase-phlorizin hydrolase (LCT) gene in adult-type hypolactasia
    A C Bulhões
    Laboratório Experimental de Gastroenterologia e Hepatologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
    Braz J Med Biol Res 40:1441-6. 2007
    ....
  59. pmc Screening of variants for lactase persistence/non-persistence in populations from South Africa and Ghana
    Suvi Torniainen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    BMC Genet 10:31. 2009
    ....
  60. pmc A genetic test which can be used to diagnose adult-type hypolactasia in children
    H Rasinpera
    HospGenetics, University of Helsinki, Finland
    Gut 53:1571-6. 2004
    ..lactose malabsorption) affects most of world's human population and limits the use of fresh milk due to lactose intolerance. The diagnosis of adult-type hypolactasia has been difficult to establish because of unsatisfactory ..
  61. ncbi Associations between lactase persistence and the metabolic syndrome in a cross-sectional study in the Canary Islands
    Ricardo Almon
    Family Medicine Research Centre, Orebro University, Sweden
    Eur J Nutr 49:141-6. 2010
    ..The single nucleotide polymorphism (SNP) LCT -13910 C>T, associated with genetically determined phenotypes of lactase persistence (LP) or non-persistence (LNP), was studied in relation to the metabolic syndrome (MS)...
  62. pmc Lactase non-persistence and milk consumption in Estonia
    Margus Lember
    Department of Internal Medicine, University of Tartu, Estonia
    World J Gastroenterol 12:7329-31. 2006
    ..To define the frequency of the C/T-13910 variant associated with lactase persistence/non-persistence trait and to analyze the milk consumption of lactase non-persistent subjects in Estonia...
  63. ncbi Diagnosis, symptoms, and calcium intakes of individuals with self-reported lactose intolerance
    Heather Y Lovelace
    University of British Columbia, 2205 East Mall, Vancouver, B C, Canada V6T 1Z4
    J Am Coll Nutr 24:51-7. 2005
    To determine methods of diagnosis, symptoms, and calcium intake from food and supplements for individuals with self-reported lactose intolerance.
  64. ncbi Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women
    N Enattah
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Eur J Clin Nutr 59:1105-11. 2005
    To study the relationships of molecularly defined lactose malabsorption (LM) and self-reported lactose intolerance (LI) to bone mineral density (BMD) and fractures among Finnish postmenopausal women.
  65. ncbi Molecular diagnosis of adult-type hypolactasia (lactase non-persistence)
    I E Jarvela
    Laboratory of Molecular Genetics, Helsinki University Central Hospital and Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Scand J Clin Lab Invest 65:535-9. 2005
  66. ncbi T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro
    Rikke H Lewinsky
    Department of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Denmark
    Hum Mol Genet 14:3945-53. 2005
    ..Lactase non-persistence (adult-type hypolactasia and lactose intolerance) is characterized by a decline in the expression of lactase-phlorizin hydrolase (LPH) after weaning...
  67. ncbi Evolutionary genetics: genetics of lactase persistence--fresh lessons in the history of milk drinking
    Edward Hollox
    Eur J Hum Genet 13:267-9. 2005
  68. pmc Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans
    Nabil Sabri Enattah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 81:615-25. 2007
    ....
  69. ncbi Subjective lactose intolerance in apparently healthy adults in southern Iran: Is it related to irritable bowel syndrome?
    M Saberi-Firoozi
    Department of Internal Medicine, Gastroenterohepatology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Indian J Med Sci 61:591-7. 2007
    The main symptoms of lactose intolerance are bloating, abdominal cramps, increased flatus and loose watery stools. These symptoms are similar to those of irritable bowel syndrome (IBS), which is a prevalent entity in the community.
  70. ncbi Concordance of genetic and breath tests for lactose intolerance in a tertiary referral centre
    Marcin Krawczyk
    Medical University of Lublin, Poland
    J Gastrointestin Liver Dis 17:135-9. 2008
    ..The aim of the study was to compare the results of both tests in detecting lactose non-persistence in a tertiary referral centre...
  71. ncbi Lactose intolerance: a non-allergic disorder often managed by allergologists
    A Perino
    Ospedale S Luigi, Unversità degli Studi di Torino
    Eur Ann Allergy Clin Immunol 41:3-16. 2009
    ..This condition is known as lactose intolerance. Lactase non-persistence is the ancestral state, whilst two single nucleotide polymorphisms in the lactase ..
  72. ncbi Impact of molecularly defined hypolactasia, self-perceived milk intolerance and milk consumption on bone mineral density in a population sample in Northern Europe
    Mart Kull
    Department of Internal Medicine, University of Tartu, Tartu, Estonia
    Scand J Gastroenterol 44:415-21. 2009
    ..Low lactase activity in adult-type hypolactasia (HL) and self-perceived lactose intolerance (LI) are the main limiting factors of milk intake...
  73. ncbi Irritable bowel syndrome: is the search for lactose intolerance justified?
    T J Parker
    Department of Gastroenterology, Addenbrooke s Hospital, Cambridge, UK
    Eur J Gastroenterol Hepatol 13:219-25. 2001
    ..To determine if confirmation of hypolactasia offers any benefit to the dietary treatment of patients with irritable bowel syndrome (IBS)...
  74. ncbi Lactose intolerance: problems in diagnosis and treatment
    A D Shaw
    Nutrition Research Centre, School of Applied Science, South Bank University, London, United Kingdom
    J Clin Gastroenterol 28:208-16. 1999
    ..Symptom similarity and the resultant incorrect diagnosis of IBS may explain the refractory nature of some patients labeled as IBS who remain largely unaware of the relationship between food intake and symptoms...
  75. ncbi Lactose maldigestion, calcium intake and osteoporosis in African-, Asian-, and Hispanic-Americans
    K A Jackson
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907-1260, USA
    J Am Coll Nutr 20:198S-207S. 2001
    ....
  76. ncbi Lactose intolerance: a self-fulfilling prophecy leading to osteoporosis?
    Dennis Savaiano
    Purdue University, Stone Hall Room 110, 700 W State Street, West Lafayette, IN, 47907 2059, USA
    Nutr Rev 61:221-3. 2003
    Symptoms of lactose intolerance are unlikely to occur under usual dietary conditions. Yet, self-described "lactose-intolerant" individuals often restrict dairy and calcium intake...
  77. ncbi Familial aquagenic urticaria associated with familial lactose intolerance
    Regina Treudler
    Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Germany
    J Am Acad Dermatol 47:611-3. 2002
    ..familial occurrence of aquagenic urticaria over 3 generations is reported here in association with familial lactose intolerance, a condition in which the enzyme lactase encoded on chromosome 2, is deficient...
  78. ncbi Incidence and clinical significance of lactose malabsorption in adult coeliac disease
    S Bode
    Dept of Internal Medicine and Gastroenterology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
    Scand J Gastroenterol 23:484-8. 1988
    ..The lactose activity in a proximal intestinal biopsy specimen was found to be an unreliable indicator of lactose malabsorption in coeliac disease...
  79. ncbi Intolerance to lactose and other dietary sugars
    D M Swallow
    Medical Research Council Human Biochemical Genetics Unit, Galton Laboratory, Department of Biology, London, United Kingdom
    Drug Metab Dispos 29:513-6. 2001
    ..This article reviews this topic and discusses in more detail the current state of our own research on lactase...
  80. ncbi The myth of increased lactose intolerance in African-Americans
    Katherine G Byers
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
    J Am Coll Nutr 24:569S-73S. 2005
    In the United States, approximately three fourths of African-Americans have the potential for symptoms of lactose intolerance because lactose digestion depends on the presence of the enzyme lactase-phlorizin hydrolase which is reduced by ..
  81. ncbi Introducing genetic testing for adult-type hypolactasia
    Carsten Buning
    Department of Gastroenterology, Hepatology and Endocrinology, Charite, Campus Mitte, Humboldt University of Berlin, Berlin, Germany
    Digestion 71:245-50. 2005
    To evaluate genotyping for two DNA variants (c.1993+327C>T and c.1438+117G>A), recently found to be associated with adult-type hypolactasia, in the diagnosis of lactose intolerance.
  82. ncbi Lactose intolerance in patients with irritable bowel syndrome from northern India: a case-control study
    Dinesh Gupta
    Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Gastroenterol Hepatol 22:2261-5. 2007
    Symptoms of irritable bowel syndrome (IBS) and lactose intolerance (LI) overlap. Data on the frequency of LI in patients with IBS from India are scanty...
  83. ncbi High prevalence of celiac disease in patients with lactose intolerance
    Veronica Ojetti
    Internal Medicine, Catholic University, Rome, Italy
    Digestion 71:106-10. 2005
    ..Several studies have highlighted the prevalence of lactose intolerance in celiac disease, but studies assessing the prevalence of celiac disease in lactose intolerance are ..
  84. ncbi Lactose intolerance in different types of irritable bowel syndrome in north Indians
    S V Rana
    Department of Superspeciality of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Trop Gastroenterol 22:202-4. 2001
    Twenty-five patients of irritable bowel syndrome (IBS) and 25 normal healthy individuals serving as controls, were studied for lactose intolerance.
  85. pmc Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency
    Mikko Kuokkanen
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 78:339-44. 2006
    ..Further, our data demonstrate that, in contrast to common adult-type hypolactasia (lactose intolerance) caused by a variant of the regulatory element, the severe infancy form represents the outcome of mutations ..
  86. ncbi Lactose intolerance
    Daniel L Swagerty
    Department of Family Medicine, University of Kansas School of Medicine, Kansas City 66160 7370, USA
    Am Fam Physician 65:1845-50. 2002
    Persons with lactose intolerance are unable to digest significant amounts of lactose because of a genetically inadequate amount of the enzyme lactase...
  87. ncbi Lactose intolerance in infants, children, and adolescents
    Melvin B Heyman
    Pediatrics 118:1279-86. 2006
    The American Academy of Pediatrics Committee on Nutrition presents an updated review of lactose intolerance in infants, children, and adolescents...
  88. ncbi Single nucleotide polymorphism C/T(-13910), located upstream of the lactase gene, associated with adult-type hypolactasia: validation for clinical practice
    Rejane Mattar
    Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, SP, Brazil
    Clin Biochem 41:628-30. 2008
    ..To validate C/T(-13910) polymorphism associated with primary hypolactasia for clinical practice...
  89. ncbi Review article: lactose intolerance in clinical practice--myths and realities
    M C E Lomer
    Department of Gastroenterology, Guy s and St Thomas NHS Foundation Trust, London, UK
    Aliment Pharmacol Ther 27:93-103. 2008
    ..However, not everyone has lactose intolerance, as several nutritional and genetic factors influence tolerance.
  90. ncbi Correlation between symptoms developed after the oral ingestion of 50 g lactose and results of hydrogen breath testing for lactose intolerance
    L Beyerlein
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Aliment Pharmacol Ther 27:659-65. 2008
    Lactase deficiency is a common condition responsible for various abdominal symptoms. Lactose hydrogen breath test is currently the gold standard in diagnosing lactose intolerance.
  91. ncbi Do probiotics reduce adult lactose intolerance? A systematic review
    Kara M Levri
    University of Pittsburgh Medical Center St Margaret, 3937 Butler Street, Pittsburgh, PA 15201, USA
    J Fam Pract 54:613-20. 2005
    To assess the efficacy of oral probiotics in adults with lactose intolerance through a systematic review of its effects on symptoms and breath hydrogen tests, and whether adding probiotics to nonfermented dairy products decreases lactose ..
  92. pmc Absence of the lactase-persistence-associated allele in early Neolithic Europeans
    J Burger
    Johannes Gutenberg University, Institute of Anthropology, Saarstrasse 21, D 55099 Mainz, Germany
    Proc Natl Acad Sci U S A 104:3736-41. 2007
    ..We did not observe the allele most commonly associated with LP in Europeans, thus providing evidence for the culture-historical hypothesis, and indicating that LP was rare in early European farmers...
  93. ncbi Visceral hypersensitivity and intolerance symptoms in lactose malabsorption
    M Di Stefano
    Department of Medicine, IRCCS S Matteo Hospital, University of Pavia, Pavia, Italy
    Neurogastroenterol Motil 19:887-95. 2007
    ..functional symptoms, we evaluated whether an alteration of visceral sensitivity is present in subjects with lactose intolerance. Thirty subjects, recruited regardless of whether they were aware of their capacity to absorb lactose, ..
  94. ncbi Lactose intolerance: lactose tolerance test versus genotyping
    Peter Ridefelt
    Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden
    Scand J Gastroenterol 40:822-6. 2005
    Adult lactose intolerance, which affects the majority of the population in the world, has been associated with a single nucleotide polymorphism, C-13910T, located upstream of the lactase gene.
  95. pmc Overcoming the barrier of lactose intolerance to reduce health disparities
    Judith K Jarvis
    National Dairy Council, Rosemont, Illinois 60018 5616 USA
    J Natl Med Assoc 94:55-66. 2002
    ..Although lactose intolerance may be partly to blame for the low calcium intakes due to reduced dairy food consumption by minority ..
  96. ncbi Genetics of lactase persistence and lactose intolerance
    Dallas M Swallow
    Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, England
    Annu Rev Genet 37:197-219. 2003
    ..This single nucleotide polymorphism is located 14 kb upstream from the start of transcription of lactase in an intron of the adjacent gene MCM6. This change does not, however, explain all the variation in lactase expression...
  97. ncbi The relationship between lactose tolerance test results and symptoms of lactose intolerance
    M M Hermans
    Department of Gastroenterology, University Hospital Maastricht, The Netherlands
    Am J Gastroenterol 92:981-4. 1997
    ..In this study, we have tried to elucidate the relationship between lactose tolerance test results and symptoms after a lactose challenge. This relationship might be an indicator for the validity of the test...
  98. ncbi An upstream polymorphism associated with lactase persistence has increased enhancer activity
    Jesper T Troelsen
    Department of Medical Biochemistry and Genetics, Biochemical Laboratory C, The Panum Institute, University of Copenhagen, Denmark
    Gastroenterology 125:1686-94. 2003
    ..The aim of this study was to investigate the role of these nucleotide polymorphisms for lactase-phlorizin hydrolase (LPH) gene expression...
  99. pmc Assignment of the locus for congenital lactase deficiency to 2q21, in the vicinity of but separate from the lactase-phlorizin hydrolase gene
    I Jarvela
    Department of Human Molecular Genetics, National Public Health Institute, Finland
    Am J Hum Genet 63:1078-85. 1998
    ..Surprisingly, the LPH gene was shown to lie outside the critical CLD region, excluding it as a causative gene for CLD. The LPH locus was found to reside >2 Mb from the critical CLD region...
  100. ncbi Evaluation of a new DNA test compared with the lactose hydrogen breath test for the diagnosis of lactase non-persistence
    Christoph Hogenauer
    Department of Internal Medicine, Medical University of Graz, Austria
    Eur J Gastroenterol Hepatol 17:371-6. 2005
    ..We therefore compared the value of DNA testing for this variant (DNA test) with the lactose hydrogen breath test (H2 test), which is the clinical standard for the diagnosis of lactase non-persistence...
  101. ncbi Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element
    Lynne C Olds
    Department of Pediatrics, Stanford University School of Medicine, 750 Welch Road, Suite 116, Palo Alto, CA 94305, USA
    Hum Mol Genet 12:2333-40. 2003
    ..Such differential regulation by the C and T variants is consistent with a causative role in the mechanism specifying the lactase persistence/non-persistence phenotypes in humans...

Research Grants21

  1. Maturational Regulation of Lactase Gene Transcription
    Eric Sibley; Fiscal Year: 2002
    ....
  2. Metabolic consequences of sickle cell anemia
    Maciej Buchowski; Fiscal Year: 2005
    ..abstract_text> ..
  3. Safe and Effective Vitamin D Supplementation in HIV
    Virginia A Stallings; Fiscal Year: 2012
    ..Poor vit D status is common in HIV/AIDS patients of all ages and factors such as age, skin pigment, lactose intolerance, and sun exposure alter the risks for vit D deficiency. In the multicenter U.S...
  4. Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent Weight
    Joan Lappe; Fiscal Year: 2012
    ..Exclusion criteria include: total body bone mineral content (TBBMC) Z score <-2;pregnancy, lactose intolerance, early menarche, or any health problem...
  5. A Transcutaneous Gas Sensor for Noninvasive Diagnosis of Necrotizing Enterocoliti
    OOMMAN VARGHESE; Fiscal Year: 2009
    ..of a titania nanotube-based hydrogen sensor to monitor transcutaneous hydrogen levels for predicting lactose intolerance in volunteer patients...
  6. Fold Specific & Entropic Adaptation
    Nicholas Panasik; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Lactose Intolerance is an increasingly prevalent malady that affects 20% of the American population, 90% of African Americans, 95% of Asian Americans, and 99% of Native Americans...
  7. BUILDING BETTER BONES IN CHILDREN
    Babette Zemel; Fiscal Year: 2003
    ..risk factors for low bone density (previous fracture from usual childhood activities, daily refusal, or lactose intolerance, family history of osteoporosis)...
  8. PRODUCING LACTOLYZED MILK AND WHEY BY MONOLITHIC SUPPORT
    ABDUL MAZID; Fiscal Year: 1999
    ..Because of widespread lactose intolerance, it is of utmost importance to have inexpensive processes for preparing dairy foods in which lactose is ..
  9. Characterization of the P5 Subfamily of P-type Transport ATPases in Mice
    PATRICK SCHULTHEIS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..
  11. Magnesium Deficiency: Global Gene Expression Study
    PATRICK SCHULTHEIS; Fiscal Year: 2002
    ..This combination of techniques should lead to the identification of all genes that are differentially expressed during magnesium deficiency. ..
  12. Physical Activity Energy Expenditure and Adolescent Obesity
    Maciej Buchowski; Fiscal Year: 2007
    ..abstract_text> ..
  13. MODELING DNA DIVERSITY IN CARDIOVASCULAR HEALTH/DISEASE
    Kenneth Weiss; Fiscal Year: 2001
    ..These studies will provide an unprecedented ..
  14. Epidemiology of Celiac Disease: A Population Based Study
    Joseph A Murray; Fiscal Year: 2010
    ..This will provide crucial data that will determine the need for early detection by screening and treatment of silent celiac disease, which may affect 1% of Americans. ..
  15. A HLA Mouse Model for Gluten Sensitivity and Enteropathy
    Joseph Murray; Fiscal Year: 2009
    ..abstract_text> ..
  16. Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism
    Carlos Camargo; Fiscal Year: 2008
    ..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
  17. A novel approach to predict energy of physical activity
    Maciej Buchowski; Fiscal Year: 2008
    ..In addition, our study will improve and validate EEAcT prediction by several market-available PA monitors, thus offering immediate benefits to their applications in the field. ..
  18. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
  19. DEVELOPMENTAL REGULATION OF LACTASE GENE TRANSCRIPTION
    Eric Sibley; Fiscal Year: 2003
    ....
  20. Neonatal Nutrition and the Genetics of Human Lactation
    Richard Weinberg; Fiscal Year: 2003
    ..This knowledge could eventually enable the identification of women who require specific fatty acid or vitamin supplementation to assure optimal infant nutrition. ..
  21. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..