iron deficiency anemia

Summary

Summary: Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.

Top Publications

  1. ncbi Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients
    Erkan Coban
    Department of Internal Medicine, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    Acta Haematol 112:126-8. 2004
  2. ncbi Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial
    Sunil Sazawal
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Lancet 367:133-43. 2006
  3. ncbi Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship
    J D Haas
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853 6301, USA
    J Nutr 131:676S-688S; discussion 688S-690S. 2001
  4. ncbi Anemia and iron deficiency: effects on pregnancy outcome
    L H Allen
    Department of Nutrition, University of California, Davis 95616 8669, USA
    Am J Clin Nutr 71:1280S-4S. 2000
  5. ncbi An analysis of anemia and pregnancy-related maternal mortality
    B J Brabin
    Liverpool School of Tropical Medicine, Liverpool, England
    J Nutr 131:604S-614S; discussion 614S-615S. 2001
  6. pmc Ferumoxytol for treating iron deficiency anemia in CKD
    Bruce S Spinowitz
    Nephrology, New York Hospital Medical Center, Queens, New York, USA
    J Am Soc Nephrol 19:1599-605. 2008
  7. ncbi The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia
    George N Ioannou
    Department of Medicine and Division of Gastroenterology, University of Washington Medical Center, and VA Medical Center, 1660 S Columbian Way, Seattle, WA 98108, USA
    Gastroenterology 126:1293-301. 2004
  8. pmc Preschool-aged children with iron deficiency anemia show altered affect and behavior
    Betsy Lozoff
    Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109 0406, USA
    J Nutr 137:683-9. 2007
  9. ncbi Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications
    Igor Theurl
    Department of Internal Medicine I, Medical University of Innsbruck, Austria
    Blood 113:5277-86. 2009
  10. ncbi Maternal iron deficiency anemia affects postpartum emotions and cognition
    John L Beard
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 135:267-72. 2005

Detail Information

Publications334 found, 100 shown here

  1. ncbi Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients
    Erkan Coban
    Department of Internal Medicine, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    Acta Haematol 112:126-8. 2004
    ..Previous studies suggest that iron deficiency anemia (IDA) affects the levels of HbA1c...
  2. ncbi Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial
    Sunil Sazawal
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Lancet 367:133-43. 2006
    ..However, there is concern that universal supplementation of children with iron and folic acid in areas of high malaria transmission might be harmful...
  3. ncbi Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship
    J D Haas
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853 6301, USA
    J Nutr 131:676S-688S; discussion 688S-690S. 2001
    ..This may also extend to the segment of the population experiencing IDNA in whom the effects on work capacity may be more subtle, but the number of individuals thus affected may be considerably more than those experiencing IDA...
  4. ncbi Anemia and iron deficiency: effects on pregnancy outcome
    L H Allen
    Department of Nutrition, University of California, Davis 95616 8669, USA
    Am J Clin Nutr 71:1280S-4S. 2000
    ..Current knowledge indicates that iron deficiency anemia in pregnancy is a risk factor for preterm delivery and subsequent low birth weight, and possibly for ..
  5. ncbi An analysis of anemia and pregnancy-related maternal mortality
    B J Brabin
    Liverpool School of Tropical Medicine, Liverpool, England
    J Nutr 131:604S-614S; discussion 614S-615S. 2001
    ..The iron deficiency component of these is unknown...
  6. pmc Ferumoxytol for treating iron deficiency anemia in CKD
    Bruce S Spinowitz
    Nephrology, New York Hospital Medical Center, Queens, New York, USA
    J Am Soc Nephrol 19:1599-605. 2008
    ..This regimen may offer a new, efficient option to treat iron deficiency anemia in patients with CKD.
  7. ncbi The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia
    George N Ioannou
    Department of Medicine and Division of Gastroenterology, University of Washington Medical Center, and VA Medical Center, 1660 S Columbian Way, Seattle, WA 98108, USA
    Gastroenterology 126:1293-301. 2004
    Our aim was to investigate the relationship between alcohol consumption and iron overload, iron deficiency, or iron deficiency anemia in the U.S. population.
  8. pmc Preschool-aged children with iron deficiency anemia show altered affect and behavior
    Betsy Lozoff
    Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109 0406, USA
    J Nutr 137:683-9. 2007
    ..compared social looking and response to novelty in preschool-aged children (47-68 mo) with or without iron deficiency anemia (IDA)...
  9. ncbi Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications
    Igor Theurl
    Department of Internal Medicine I, Medical University of Innsbruck, Austria
    Blood 113:5277-86. 2009
    ..Many patients, however, present with both ACD and iron deficiency anemia (ACD/IDA), the latter resulting from chronic blood loss...
  10. ncbi Maternal iron deficiency anemia affects postpartum emotions and cognition
    John L Beard
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 135:267-72. 2005
    The aim of this study was to determine whether iron deficiency anemia (IDA) in mothers alters their maternal cognitive and behavioral performance, the mother-infant interaction, and the infant's development...
  11. pmc Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
    Karin E Finberg
    Pathology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:569-71. 2008
    ..Iron deficiency is usually attributed to chronic blood loss or inadequate dietary intake. Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II ..
  12. ncbi Iron deficiency anemia
    Susan F Clark
    Virginia Polytechnic Institute and State University, Department of Human Nutrition, Foods and Exercise, Blacksburg, VA 24061, USA
    Nutr Clin Pract 23:128-41. 2008
    The most severe consequence of iron depletion is iron deficiency anemia (IDA), and it is still considered the most common nutrition deficiency worldwide...
  13. pmc Treatment of iron deficiency anemia associated with gastrointestinal tract diseases
    Ulas D Bayraktar
    Division of Hematology and Oncology, Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Ave, St 3300, Miami, FL 33136, USA
    World J Gastroenterol 16:2720-5. 2010
    The gastrointestinal (GI) tract is a common site of bleeding that may lead to iron deficiency anemia (IDA). Treatment of IDA depends on severity and acuity of patients' signs and symptoms...
  14. ncbi Cerebral venous sinus thrombosis associated with iron deficiency: two case reports
    Yusuke Kinoshita
    Department of Neurosurgery, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan
    Neurol Med Chir (Tokyo) 46:589-93. 2006
    ..Severe dehydration after competitive sport had induced CVST. The laboratory findings showed severe iron deficiency anemia which persisted for 1 year. A 47-year-old man had thrombosis in the entire superior sagittal sinus...
  15. ncbi Assessing iron status: beyond serum ferritin and transferrin saturation
    Jay B Wish
    University Hospitals of Cleveland and Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin J Am Soc Nephrol 1:S4-8. 2006
    ..Finally, the role of hepcidin, a hepatic polypeptide, in the pathophysiology of iron mobilization is reviewed briefly...
  16. ncbi Helicobacter pylori-related iron deficiency anemia: a review
    Arrigo Barabino
    Pediatric Gastroenterology, G Gaslini Institute, Genoa, Italy
    Helicobacter 7:71-5. 2002
    ..have demonstrated that Helicobacter pylori gastric infection has emerged as a new cause of refractory iron deficiency anemia, unresponsive to iron therapy, and not attributable to usual causes such as intestinal losses or poor ..
  17. ncbi Development of a clinical prediction rule for iron deficiency anemia in pregnancy
    Bruno F Casanova
    Department of Obstetrics and Gynecology, Pennsylvania Hospital, University of Pennsylvania, Philadelphia 19107, USA
    Am J Obstet Gynecol 193:460-6. 2005
    ..The purpose of this study was to elucidate if anemia in pregnancy caused by iron deficiency could be predicted by simple measures obtained on a complete blood count (CBC) using ferritin as the gold standard...
  18. ncbi Platelet counts in adults with iron deficiency anemia
    Irfan Kuku
    Department of Hematology, Inonu University, Malatya, Turkey
    Platelets 20:401-5. 2009
    In adults with iron deficiency anemia (IDA), abnormal platelet counts were seen in several studies. However we retrospectively examined the clinical records of a larger number of adults with IDA to assess abnormal platelet counts...
  19. ncbi Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial
    David B Van Wyck
    DaVita, Inc, Tucson, Arizona, USA
    Transfusion 49:2719-28. 2009
    The objective was to evaluate efficacy and safety of rapid, large-dose intravenous (IV) administration of ferric carboxymaltose compared to oral iron in correcting iron deficiency anemia due to heavy uterine bleeding.
  20. ncbi Serum transferrin receptor and zinc protoporphyrin as indicators of iron status in African children
    Michael B Zimmermann
    Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 81:615-23. 2005
    ..Although transferrin receptor (TfR) and zinc protoporphyrin (ZnPP) are often used to define iron status in school-age children in developing countries, the diagnostic cutoffs for this age group are uncertain...
  21. ncbi Is There a Causal Relationship between Iron Deficiency or Iron-Deficiency Anemia and Weight at Birth, Length of Gestation and Perinatal Mortality?
    K Rasmussen
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853
    J Nutr 131:590S-601S; discussion 601S-603S. 2001
    ....
  22. ncbi An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function
    Joyce C McCann
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Am J Clin Nutr 85:931-45. 2007
    ..In children >2 y of age and in adolescents with ID-A, evidence suggests cognitive or behavioral deficits; however, the surprisingly small number of studies conducted in either humans or animals prevents a thorough assessment...
  23. pmc Effects of iron supplementation on maternal hematologic status in pregnancy
    Nancy L Sloan
    Population Council, New York, NY 10017, USA
    Am J Public Health 92:288-93. 2002
    ..This article reviews the efficacy of iron supplementation on hemoglobin levels in pregnant women in developing countries...
  24. ncbi Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease
    David A Weinstein
    Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 100:3776-81. 2002
    ..We conclude that hepcidin plays a major, causative role in the anemia observed in our subgroup of patients with hepatic adenomas, and we speculate that it is important in the pathogenesis of the anemia of chronic disease in general...
  25. ncbi Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency
    Rustam I Usmanov
    Republican Research Center of Emergency Medicine of Uzbekistan, Tashkent, Uzbekistan
    J Nephrol 21:236-42. 2008
    b>Iron deficiency anemia is a frequent finding in many patients with congestive heart failure (CHF). The purpose of this study was to assess the effect of intravenous (i.v...
  26. pmc Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
    Gael Nicolas
    Département de génétique, Developpement et Pathologie Moleculaire, Institut Cochin, Centre National de la Recherche Scientifique, et Université René Descartes, Faculté de Médecine Cochin Port Royal, 75014 Paris, France
    Proc Natl Acad Sci U S A 99:4596-601. 2002
    ....
  27. ncbi Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency
    Christian Thomas
    Laboratoriumsmedizin, Krankenhaus Nordwest, Steinbacher Hohl 2 26, 60488 Frankfurt Main, Germany
    Clin Chem 48:1066-76. 2002
    ....
  28. pmc Ferumoxytol as an intravenous iron replacement therapy in hemodialysis patients
    Robert Provenzano
    St John Hospital and Medical Center, Detroit, Michigan, USA
    Clin J Am Soc Nephrol 4:386-93. 2009
    ..Intravenous iron is a key component of anemia management for chronic kidney disease (CKD). Ferumoxytol is a unique intravenous iron product that can be administered as a rapid injection in doses up to 510 mg...
  29. ncbi A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT) randomized controlled trial
    Stefanie Kulnigg
    Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Am J Gastroenterol 103:1182-92. 2008
    ..IBD) This multicenter study tested the noninferiority and safety of a new intravenous iron preparation, ferric carboxymaltose (FeCarb), in comparison with oral ferrous sulfate (FeSulf) in reducing iron deficiency anemia (IDA) in IBD.
  30. ncbi Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease--a randomized, controlled, open-label, multicenter study
    Oliver Schroder
    First Department of Internal Medicine, Division of Gastroenterology, ZAFES, Johann Wolfgang Goethe University, Frankfurt, Germany
    Am J Gastroenterol 100:2503-9. 2005
    ..We therefore evaluated the efficacy and safety of intravenous iron sucrose as compared with oral iron sulfate for the treatment of iron deficiency anemia (IDA) in patients with IBD.
  31. ncbi Child food insecurity and iron deficiency anemia in low-income infants and toddlers in the United States
    Anne Skalicky
    Boston University School of Public Health, Massachusetts 02118, USA
    Matern Child Health J 10:177-85. 2006
    ..Examine the association between child-level food insecurity and iron status in young children utilizing community-based data from the Children's Sentinel Nutrition Assessment Program (C-SNAP)...
  32. pmc Micronutrient sprinkles to control childhood anaemia
    Stanley H Zlotkin
    Division of GI Nutrition at the Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS Med 2:e1. 2005
  33. ncbi Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications
    Erwin H J M Kemna
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem 53:620-8. 2007
    ..Recent reports on the measurement of urine and serum hepcidin by surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) necessitate analytical and clinical evaluation of MS-based methodologies...
  34. ncbi Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women
    Pham Van Thuy
    National Institute of Nutrition, Hanoi, Vietnam
    Am J Clin Nutr 78:284-90. 2003
    ..Fish sauce is consumed daily by a large proportion of the Vietnamese population and could therefore be a potentially useful food vehicle for iron-fortification programs...
  35. ncbi Zinc protoporphyrin: A metabolite with a mission
    R F Labbe
    Department of Laboratory Medicine, Box 359743, University of Washington, Seattle, WA 98104, USA
    Clin Chem 45:2060-72. 1999
    ..Biochemical research techniques, both in vivo and in vitro, are described for further studies into the role of ZnPP in metabolism and physiology...
  36. ncbi Iron deficiency and Helicobacter pylori infection in the United States
    Victor M Cardenas
    Division of Epidemiology, University of Texas School of Public Health, El Paso, USA
    Am J Epidemiol 163:127-34. 2006
    ..4, 95% CI: 0.9, 2.0) after controlling for relevant covariates. In the United States, H. pylori infection was associated with iron deficiency/IDA regardless of the presence or absence of peptic ulcer disease...
  37. ncbi Iron deficiency anaemia among children and pregnant women in the Arab Gulf countries: the need for action
    Abdulrahman O Musaiger
    Environmental and Biological Programme, Bahrain Center for Studies and Research, Manama
    Nutr Health 16:161-71. 2002
    ..Programmes to prevent and control this anaemia, are urgently needed...
  38. ncbi Iron-deficiency anemia: reexamining the nature and magnitude of the public health problem. Summary: implications for research and programs
    R J Stoltzfus
    Center for Human Nutrition, Department of International Health, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Nutr 131:697S-700S; discussion 700S-701S. 2001
    ..The simple model depicting severe anemia and tissue iron deficiency as distinct but overlapping entities with distinct functional outcomes is presented and may be useful in designing and evaluating programs...
  39. ncbi Nutrition and maternal mortality in the developing world
    D Rush
    School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 72:212S-240S. 2000
    ..5 m in height should be excluded from supplementary feeding programs aimed at accelerating fetal growth. The knowledge base to model the risks and benefits of increased fetal size does not exist...
  40. ncbi Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion
    Tadashi Nagai
    Division of Hematology, Jichi Medical School, Tochigi
    Intern Med 44:1090-2. 2005
    We report a case of severe iron deficiency anemia with marked thrombocytosis that was complicated by central retinal vein occlusion...
  41. pmc A history of iron deficiency anemia during infancy alters brain monoamine activity later in juvenile monkeys
    Christopher L Coe
    Harlow Center for Biological Psychology, University of Wisconsin, 22 North Charter Street, Madison, WI 53715, USA
    Dev Psychobiol 51:301-9. 2009
    ....
  42. ncbi Diagnosis of iron deficiency anemia in the elderly by transferrin receptor-ferritin index
    Ephraim Rimon
    Department of Geriatrics, Kaplan Medical Center, Rehovot, Israel 76100
    Arch Intern Med 162:445-9. 2002
    The diagnosis of iron deficiency anemia (IDA) in the elderly is difficult because of the prevalence of chronic diseases, which can cause anemia with high ferritin levels, even in the presence of iron deficiency...
  43. ncbi Ferric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: a randomized controlled clinical trial
    Melvin H Seid
    Lyndhurst Gynecologic Associates, Winston Salem, NC 27103, USA
    Am J Obstet Gynecol 199:435.e1-7. 2008
    ..The objective of the study was to evaluate the efficacy, safety, and tolerability of intravenous ferric carboxymaltose, compared with oral ferrous sulfate in women with postpartum anemia...
  44. ncbi Iron deficiency anemia
    A K Leung
    The University of Calgary, and Alberta Children's Hospital, Canada
    Adv Pediatr 48:385-408. 2001
    b>Iron deficiency anemia is the most common cause of anemia worldwide and results from inadequate iron supply for erythropoiesis. Iron deficiency is most prevalent during periods of rapid body growth: in infancy and again at puberty...
  45. ncbi Mother-infant interactions and infant development are altered by maternal iron deficiency anemia
    Eva M Perez
    School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    J Nutr 135:850-5. 2005
    The aim of this study was to determine whether iron deficiency anemia (IDA) in young South African mothers alters mother-infant interactions and the infant's development...
  46. ncbi Prevalence of anemia among pregnant women and adolescent girls in 16 districts of India
    G S Toteja
    Indian Council of Medical Research, Ansari Nagar, New Delhi
    Food Nutr Bull 27:311-5. 2006
    ..Under the anemia prevention and control program of the Government of India, iron and folic acid tablets are distributed to pregnant women, but no such program exists for adolescent girls...
  47. ncbi Lymphocyte DNA damage and oxidative stress in patients with iron deficiency anemia
    Mehmet Aslan
    Harran University, School of Medicine, Department of Internal Medicine, Sanliurfa, Turkey
    Mutat Res 601:144-9. 2006
    Oxidant stress has been shown to play an important role in the pathogenesis of iron deficiency anemia. The aim of this study was to investigate the association between lymphocyte DNA damage, total antioxidant capacity and the degree of ..
  48. ncbi The use of sweet rolls fortified with iron bis-glycinate chelate in the prevention of iron deficiency anemia in preschool children
    E Giorgini
    Health and Nutrition Research Center, San Marcos University, Federal University, Sao Paulo, Brazil
    Arch Latinoam Nutr 51:48-53. 2001
    The effectiveness of bread fortified with iron bis-glycinate chelate for the control of iron deficiency and iron deficiency anemia was evaluated in 89 preschool children from families of low socioeconomic level attending 2 day nurseries ..
  49. ncbi Prevalence of anemia in children 6-59 months old in the state of Pernambuco, Brazil
    M M Osorio
    Universidade Federal de Pernambuco, Departamento de Nutricao, Recife, Pernambuco, Brazil
    Rev Panam Salud Publica 10:101-7. 2001
    ..To determine the prevalence of anemia in children 6-59 months old in Pernambuco, a state in northeastern Brazil, so as to help guide health and nutrition policies there...
  50. pmc Iron deficiency anemia and affective response in rhesus monkey infants
    Mari S Golub
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    Dev Psychobiol 51:47-59. 2009
    Infant iron deficiency anemia (IDA) occurs spontaneously in monkey populations as it does in humans, providing a model for understanding effects on brain and behavior...
  51. ncbi Iron deficiency and risk factors for lower iron stores in 6-24-month-old New Zealanders
    P Soh
    Department of Human Nutrition, University of Otago, Dunedin, New Zealand
    Eur J Clin Nutr 58:71-9. 2004
    ..To determine the prevalence of biochemical iron deficiency and identify factors associated with ferritin levels among 6-24-month-old urban South Island New Zealand children...
  52. ncbi Child health and nutrition in the Western Brazilian Amazon: population-based surveys in two counties in Acre State
    Pascoal Torres Muniz
    Departamento de Ciências da Saúde, Universidade Federal do Acre, Rio Branco, Brazil
    Cad Saude Publica 23:1283-93. 2007
    ..In both towns, anemia and malnutrition were significantly more prevalent among children in the lowest socioeconomic stratum...
  53. ncbi Fighting iron deficiency anemia with iron-rich rice
    Paola Lucca
    Institute for Plant Science ETHZ, Zurich, Switzerland
    J Am Coll Nutr 21:184S-190S. 2002
    ..Here we present experiments that aim to increase the iron content in rice endosperm and to improve its absorption in the human intestine by means of genetic engineering...
  54. ncbi Parenteral iron therapy options
    Scott B Silverstein
    Department of Pharmacy Services, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Am J Hematol 76:74-8. 2004
    ..The increased availability of multiple parenteral iron preparations should decrease the need to use red cell transfusions in patients with iron-deficiency anemia...
  55. pmc Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis
    Xin Hua Qu
    Renji Hospital, Shanghai Jiaotong University School of Medicine, 1630 Dongfang Road, Shanghai 200127, China
    World J Gastroenterol 16:886-96. 2010
    To perform a meta-analysis of observational studies and randomized controlled trials (RCTs) on the association between Helicobacter pylori (H. pylori) and iron deficiency anemia (IDA).
  56. ncbi Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants
    Staffan Berglund
    Umea University, Department of Clinical Sciences, Division of Pediatrics, SE 901 85 Umea, Sweden
    Pediatrics 126:e874-83. 2010
    ..Most LBW infants have marginally low birth weight (MLBW, 2000-2500 g) and it is not known whether they benefit from iron supplements. The objective of this trial was to study the effects of iron supplementation in MLBW infants...
  57. ncbi Iron metabolism and requirements in early childhood: do we know enough?: a commentary by the ESPGHAN Committee on Nutrition
    Peter J Aggett
    University of Lancashire, Lancashire, United Kingdom
    J Pediatr Gastroenterol Nutr 34:337-45. 2002
  58. ncbi Iron deficiency anemia
    Shersten Killip
    Department of Family and Community Medicine, University of Kentucky, Lexington, Kentucky, USA
    Am Fam Physician 75:671-8. 2007
    The prevalence of iron deficiency anemia is 2 percent in adult men, 9 to 12 percent in non-Hispanic white women, and nearly 20 percent in black and Mexican-American women...
  59. ncbi Prevalence of iron deficiency anemia in 6 months to 5 years old children in Fars, Southern Iran
    Mohamad Rahim Kadivar
    Department of Pediatrics, Nemazee Hospital, Shiraz University of Medical Sciences, Iran
    Med Sci Monit 9:CR100-4. 2003
    ..Traditionally, several methods other than serum ferritin were used to assess IDA. Our main objective was to obtain the prevalence of IDA by serum ferritin in 6 month to 5-year-old children in the province of Fars in southern Iran...
  60. ncbi The role of wireless capsule endoscopy in investigating unexplained iron deficiency anemia after negative endoscopic evaluation of the upper and lower gastrointestinal tract
    P Apostolopoulos
    Department of Gastroenterology, Army Share Fund NIMTS Hospital, Athens, Greece
    Endoscopy 38:1127-32. 2006
    ..diagnostic evaluation with eosophagogastroduodenoscopy and ileocolonoscopy, up to 30% of patients with iron deficiency anemia (IDA) have no definitive diagnosis...
  61. ncbi Defining iron-deficiency anemia in public health terms: a time for reflection
    R Stoltzfus
    Center for Human Nutrition, Department of International Health, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore MD, USA
    J Nutr 131:565S-567S. 2001
    ..g., iron deficiency vs. iron-deficiency anemia vs. severe anemia from any cause) that link iron-deficiency anemia to important health outcomes and to estimate the magnitude of their effects in public health terms...
  62. ncbi Cerebral venous thrombosis associated with iron deficiency anemia
    Toshiyasu Ogata
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Stroke Cerebrovasc Dis 17:426-8. 2008
    ..He had bleeding from a peptic ulcer and the laboratory data revealed iron deficiency anemia concomitant with an elevation of D-dimer and thrombin-antithrombin III complex (TAT)...
  63. ncbi Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study
    Oliver M Theusinger
    Department of Anesthesiology, University Hospital and University of Lausanne, Switzerland
    Anesthesiology 107:923-7. 2007
    Preoperative anemia is frequent in patients undergoing orthopedic surgery. The purpose of this study was to assess the preoperative increase of hemoglobin in iron deficiency anemia patients treated with intravenous iron.
  64. doi Effect of Angelica sinensis polysaccharide-iron complex on iron deficiency anemia in rats
    Pei Pei Wang
    Pharmaceutical Preparation Section of Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430022, China
    Chin J Integr Med 13:297-300. 2007
    To investigate the therapeutic effects of Angelica sinensis polysaccharide-iron complex (APIC) on rats with iron deficiency anemia (IDA).
  65. ncbi Community mobilization and social marketing to promote weekly iron-folic acid supplementation in women of reproductive age in Vietnam: impact on anemia and iron status
    Jacques Berger
    Institute of Research for Development IRD, Research Unit, Nutrition, Food, Societies, Montpellier, France
    Nutr Rev 63:S95-108. 2005
    ..This demonstrates the effectiveness and safety of the preventive approach as implemented here to prevent and control iron deficiency and anemia in women of reproductive age before and during pregnancy...
  66. ncbi Iron-refractory iron deficiency anemia
    Karin E Finberg
    Department of Pathology, Duke University Medical Center, Durham, NC
    Semin Hematol 46:378-86. 2009
    Iron-refractory iron deficiency anemia (IRIDA) is an autosomal recessive disorder characterized by iron deficiency anemia unresponsive to oral iron treatment but partially responsive to parenteral iron therapy...
  67. ncbi Iron deficiency anemia - a rare etiology of sinus thrombosis in adults
    Pai Hao Huang
    Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
    Acta Neurol Taiwan 19:125-30. 2010
    ..CVT has been reported to be associated with various etiologies. There are, however, very few reported cases of CVT associated with iron deficiency anemia (IDA), especially in adults.
  68. ncbi Linear growth in children with iron deficiency anemia before and after treatment
    Ashraf T Soliman
    Department of Pediatrics, Hamad Medical Centre, Doha, Qatar
    J Trop Pediatr 55:324-7. 2009
    ..2 +/- 12.4 months) with iron deficiency anemia (IDA) before and after iron therapy. Before treatment children with IDA had LSDS = -1.2 +/- 1, GV = 7...
  69. ncbi Assessment of the prevalence of iron deficiency anemia, by serum ferritin, in pregnant women of Southern Iran
    Mehran Karimi
    Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Iran
    Med Sci Monit 8:CR488-92. 2002
    ..Pregnant women and children under 5 years of age are among the high-risk population. Our main objectives in this study were to obtain the prevalence of IDA in pregnant women by routine methods and by serum ferritin...
  70. ncbi Prevalence of iron deficiency anemia among adolescent schoolgirls from Kermanshah, Western Iran
    Reza Akramipour
    Department of Pediatrics, Kermanshah University of Medical Sciences, Kermanshah, Iran
    Hematology 13:352-5. 2008
    b>Iron deficiency anemia is a major health problem in developing countries. Anemia reduces physical work capacity and cognitive function and adversely affects learning and scholastic performance in schoolgirls entering adolescence...
  71. ncbi Novel TMPRSS6 mutations associated with iron-refractory iron deficiency anemia (IRIDA)
    Luigia De Falco
    CEINGE, Centro di Ingegneria Genetica e Biotecnologie Avanzate, Via Comunale Margherita 482, Naples, Italy
    Hum Mutat 31:E1390-405. 2010
    ..to abrogation of matriptase-2 proteolytic activity in humans are associated with an iron-refractory iron deficiency anemia (IRIDA) due to elevated hepcidin levels...
  72. ncbi Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial
    Mary E Cogswell
    Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Clin Nutr 78:773-81. 2003
    ..The need for prophylactic iron during pregnancy is uncertain...
  73. ncbi Effects of iron deficiency anemia on cognitive function in children
    Leyla Agaoglu
    Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
    Arzneimittelforschung 57:426-30. 2007
    To examine the effects of iron deficiency anemia on cognitive function and intelligence in children.
  74. ncbi Comparative proteomic analysis of Helicobacter pylori strains associated with iron deficiency anemia
    Shin Ae Park
    Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Kwangjin gu, Seoul, Korea
    Proteomics 6:1319-28. 2006
    ..pylori is known to cause chronic gastritis, peptic ulcer, and gastric cancer, and has also been linked to iron deficiency anemia (IDA). To determine whether H. pylori clinical isolates correlate with the prevalence of H...
  75. ncbi Are we giving too much iron? Low-dose iron therapy is effective in octogenarians
    Ephraim Rimon
    Geriatrifc Department, Kaplan Medical Center, Rehovot, and the Hebrew University and Hadassah Medical School, Jerusalem, Israel
    Am J Med 118:1142-7. 2005
    ..Our study examines whether low-dose iron therapy can efficiently resolve iron-deficiency anemia in patients over the age of 80 years and reduce adverse effects...
  76. pmc High prevalence of Helicobacter pylori in the Alaska native population and association with low serum ferritin levels in young adults
    A J Parkinson
    Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Anchorage, Alaska 99508, USA
    Clin Diagn Lab Immunol 7:885-8. 2000
    b>Iron deficiency anemia is a common public health problem in the Alaska Native population. Yet, a clear etiology has eluded researchers for decades...
  77. ncbi Comparative efficacy and safety of intravenous ferric carboxymaltose in the treatment of postpartum iron deficiency anemia
    Christian Breymann
    Feto Maternal Hematology Unit, University Hospital, Zurich, Switzerland
    Int J Gynaecol Obstet 101:67-73. 2008
    To compare the safety and efficacy of iron carboxymaltose with ferrous sulfate to treat iron deficiency anemia in the post partum.
  78. ncbi Iron fortification and iron supplementation are cost-effective interventions to reduce iron deficiency in four subregions of the world
    Rob Baltussen
    WHO CHOICE, Institute for Medical Technology Assessment, Erasmus Medical Center, Rotterdam, The Netherlands
    J Nutr 134:2678-84. 2004
    ..The results should be interpreted with caution, because evidence of intervention effectiveness predominantly relates to small-scale efficacy trials, which may not reflect the actual effect under expected conditions...
  79. ncbi Should we lower the dose of iron when treating anaemia in pregnancy? A randomized dose-response trial
    S J Zhou
    Child Nutrition Research Centre, Flinders Medical Centre and Women s and Children s Hospital, Child Health Research Institute, North Adelaide, SA, Australia
    Eur J Clin Nutr 63:183-90. 2009
    ..To compare the efficacy and side effects of low-dose vs high-dose iron supplements to correct anaemia in pregnancy...
  80. pmc A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases
    Fernando Bermejo
    Digestive Service, University Hospital of Fuenlabrada, Fuenlabrada, Madrid 28942, Spain
    World J Gastroenterol 15:4638-43. 2009
    ..Repeat endoscopic studies should be considered in many cases and if both still show normal results, investigating the small bowel must be considered. The main techniques in this case are capsule endoscopy, followed by enteroscopy...
  81. ncbi Intravenous versus oral iron therapy for postpartum anaemia
    N Bhandal
    Department of Anaesthesia, Nuffield Department of Anaesthetics, John Radcliffe Hospital, Oxford, UK
    BJOG 113:1248-52. 2006
    ..Most women are treated with either oral iron supplementation or blood transfusion. Hence, the aim of our study was to compare the effect of treatment with either oral ferrous sulphate or intravenous ferrous sucrose on postpartum IDA...
  82. pmc Evaluation and treatment of iron deficiency anemia: a gastroenterological perspective
    Amy Zhu
    Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA, USA
    Dig Dis Sci 55:548-59. 2010
    ..Since iron deficiency anemia often arises from bleeding gastrointestinal lesions, many of which are malignant, establishment of a firm ..
  83. ncbi Iron therapy in iron deficiency anemia in pregnancy: intravenous route versus oral route
    Françoise Bayoumeu
    Department of Anesthesia and Intensive Care, Maternity Hospital, Nancy, France
    Am J Obstet Gynecol 186:518-22. 2002
    ..The aim of this study was to compare intravenous iron sucrose versus oral iron sulfate in anemia at 6 months of pregnancy...
  84. ncbi Importance of RDW value in differential diagnosis of hypochrome anemias
    D Aslan
    Department of Pediatric Hematology, Ihsan Dogramaci Children s Hospital, Hacettepe University, Ankara, Turkey
    Am J Hematol 69:31-3. 2002
    ..20-40 years of age (n = 29), beta thalassemia traits (beta-TT) with an age range of 18-60 years (n = 49), iron deficiency anemia (IDA) in individuals aged 1-18 years (n = 27), and in controls with an age range of 20-40 years (n = 20)...
  85. ncbi An update on anemia in less developed countries
    Karine Tolentino
    Center for International Health Research at Rhode Island Hospital and Department of Pediatrics, Brown University Medical School, Providence, Rhode Island, USA
    Am J Trop Med Hyg 77:44-51. 2007
    ..This review will focus on recent advances in our understanding of the burden of anemia in specific sub-groups, the causes and mechanisms of anemia, and consequences of anemia for the human host...
  86. ncbi Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods
    S Zlotkin
    Departments of Paediatrics and Nutritional Sciences, The University of Toronto, Canada
    Am J Clin Nutr 74:791-5. 2001
    ..Standard therapy for anemia in infants is ferrous sulfate drops administered 3 times/d. Adherence to treatment, however, is often poor. One likely reason for poor adherence is the unpleasant side effects associated with drops...
  87. pmc Reticulocyte hemoglobin equivalent (Ret He) and assessment of iron-deficient states
    C Brugnara
    Department of Laboratory Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Lab Haematol 28:303-8. 2006
    ..2 pg, iron deficiency could be diagnosed with a sensitivity of 93.3%, and a specificity of 83.2%. Ret He is a reliable marker of cellular hemoglobin content and can be used to identify the presence of iron-deficient states...
  88. pmc New cut-off values for ferritin and soluble transferrin receptor for the assessment of iron deficiency in children in a high infection pressure area
    K S Phiri
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi
    J Clin Pathol 62:1103-6. 2009
    ..However, assessment of the iron status has proven to be difficult, especially in children living in areas with high infection pressure (including malaria)...
  89. ncbi Effects of changes in hemoglobin level on quality of life and cognitive function in inflammatory bowel disease patients
    Christopher W Wells
    North Tyneside General Hospital and the University of Newcastle Upon Tyne, Newcastle upon Tyne, United Kingdom
    Inflamm Bowel Dis 12:123-30. 2006
    ..Subsidiary aims were to assess whether the use of iron was associated with worsening DA...
  90. ncbi Only a small proportion of anemia in northeast Thai schoolchildren is associated with iron deficiency
    Rosanne A Thurlow
    Institute of Nutrition, Mahidol University, Salaya, Thailand
    Am J Clin Nutr 82:380-7. 2005
    ..Iron deficiency is assumed to be the major cause of anemia in northeast Thailand, but other factors may be involved...
  91. pmc Anemia and inflammatory bowel diseases
    Fernando Gomollon
    Gastroenterology Unit, Clinical Universitary Hospital Lozano Blesa, CIBERehd, Avenida San Juan Bosco 15, Zaragoza 50009, Spain
    World J Gastroenterol 15:4659-65. 2009
    ..Thus, the clinician caring for IBD patients should have a comprehensive knowledge of anemia, and apply recently published guidelines in clinical practice...
  92. doi The role of intravenous iron in anemia management and transfusion avoidance
    Michael Auerbach
    Private Practice, Baltimore, Maryland, USA
    Transfusion 48:988-1000. 2008
  93. ncbi Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial
    Darlington O Okonko
    Clinical Cardiology, NHLI, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 51:103-12. 2008
    ..We tested the hypothesis that intravenous iron improves exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure (CHF) and iron deficiency...
  94. ncbi Association of prohepcidin and hepcidin-25 with erythropoietin response and ferritin in hemodialysis patients
    Akihiko Kato
    Division of Blood Purification, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Am J Nephrol 28:115-21. 2008
    ..52 +/- 16 AU, p = NS). It follows from these findings that the assessment of serum hepcidin using currently available assays was not valid in predicting rHuEPO responsiveness in chronic HD patients...
  95. ncbi Risk factors for iron-deficiency anaemia among pregnant women living in rural Vietnam
    Ritsuko Aikawa
    Institute for International Cooperation, Japan International Cooperation Agency, Tokyo, Japan
    Public Health Nutr 9:443-8. 2006
    ..To assess the prevalence of anaemia in rural Vietnam and to determine its risk factors...
  96. ncbi Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
    Alicia R Folgueras
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, Spain
    Blood 112:2539-45. 2008
    ..Thus, Tmprss6(-/-) mice display an overt phenotype of alopecia and a severe iron deficiency anemia. These hematologic alterations found in Tmprss6(-/-) mice are accompanied by a marked up-regulation of ..
  97. pmc High prevalence of asymptomatic vitamin D and iron deficiency in East African immigrant children and adolescents living in a temperate climate
    George McGillivray
    Murdoch Children s Research Institute, Melbourne, Australia
    Arch Dis Child 92:1088-93. 2007
    ..We assessed the pattern of and risk factors for VDD in immigrant East African children living in Melbourne (latitude 37 degrees 49' South)...
  98. ncbi Iron deficiency and child development
    Betsy Lozoff
    Center for Human Growth and Development, Department of Pediatrics and Communicable Diseases, University of Michigan, 300 N Ingalls, Ann Arbor, MI 48109 5406, USA
    Food Nutr Bull 28:S560-71. 2007
    ..New findings also point to the need for more attention to the developmental effects of prenatal iron deficiency...
  99. ncbi Iron-deficiency anemia and Helicobacter pylori infection: a review of the evidence
    Suja DuBois
    Division of Gastroenterology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    Am J Gastroenterol 100:453-9. 2005
  100. ncbi Iron supplementation in pregnancy--does the preparation matter?
    Nir Melamed
    Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqwa, 49100, Israel
    Arch Gynecol Obstet 276:601-4. 2007
    ..To assess the use, side effects and discontinuation rates of iron preparations during pregnancy...
  101. ncbi Helicobacter pylori infection and iron stores: a systematic review and meta-analysis
    Khitam Muhsen
    Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Helicobacter 13:323-40. 2008
    ..We carried out a systematic literature review and meta-analysis to evaluate the existing evidence on the association between Helicobacter pylori infection and iron stores...

Research Grants62

  1. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ..b>Iron deficiency anemia (IDA) affects nearly 3% of children in the U.S. aged 1-2 years...
  2. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Iron deficiency anemia is the most common form of anemia affects about one in five women, half of pregnant women, 3 percent of ..
  3. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ....
  4. The Mucolipin TRP Ion Channels
    Haoxing Xu; Fiscal Year: 2013
    ..In the long term, the results should provide clinical insights into therapeutic approaches for both iron-related disorders (anemia and iron overload) and degenerative diseases (retinal and neural degeneration). ..
  5. Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk
    Sheila Gahagan; Fiscal Year: 2012
    ..10 years as part of a NIH-supported cohort study of the behavioral and developmental effects of preventing iron deficiency anemia in infancy (n = 1645)...
  6. Maternal Intestinal Infections and Low Birth Weight in a Rural Indian Cohort
    RACHEL MARGARET WHELAN; Fiscal Year: 2012
    ..The hypotheses are that these infections cause or augment pregnancy outcomes such as iron deficiency anemia during the third trimester of pregnancy and also contribute to the high incidence of low birth weight and ..
  7. The role of erythroferrone in iron homeostasis and in iron-loading anemias
    Tomas Ganz; Fiscal Year: 2013
    ..for the treatment of diseases of hepcidin excess such as anemia of inflammation or iron-refractory iron deficiency anemia (IRIDA)...
  8. Mechanistic insights into copper metabolism
    Jaekwon Lee; Fiscal Year: 2013
    ....
  9. Red Cell Deformability InVitro and Survival InVivo
    MOHANDAS NARLA; Fiscal Year: 2013
    ..hereditary ovalocytosis, thalassemias, sickle cell disease, enzymopathies, malarial anemia and iron deficiency anemia affect over billion humans...
  10. Impact of Malnutrition on HIV Treatment Failure in Resource-Limited Settings
    Amita Gupta; Fiscal Year: 2012
    ..abstract_text> ..
  11. HRI-eIF2a Phosphorylation Signaling in Oxidative Stress and Erythropoiesis
    Jane Jane Chen; Fiscal Year: 2012
    ..Recently, we uncovered a novel role of HRI in erythroid differentiation during iron deficiency anemia and in 2-thalassemia...
  12. HRI/elF2aP Signaling Pathway as Potential Pharmaceutical Targets for Thalassemia
    Jane Jane Chen; Fiscal Year: 2010
    ..This study may also lead to the discovery of novel drug treatments for red blood cell diseases. ..
  13. Mechanisms of effect of iron status &interventions on malaria &other infections
    Steven L Spitalnik; Fiscal Year: 2012
    ..in these model systems, encompasses three Specific Aims: (1) Test the hypothesis that dietary iron deficiency anemia increases the severity of the erythrocytic phases of P. berghei and P. chabaudi malaria and of S...
  14. Metalloreductases in Medicine
    Mark D Fleming; Fiscal Year: 2010
    ..the major erythroid transferrin cycle endosomal ferrireductase, Steap3, by positionally cloning the mouse iron deficiency anemia mutant nm1054...
  15. Structure and Function of Iron Regulatory Proteins
    KARL W VOLZ; Fiscal Year: 2010
    ..In humans, the failure to acquire adequate iron from the diet results in iron deficiency anemia, a major nutritional problem worldwide...
  16. Developing tools for genetic manipulation of hookworms
    John M Hawdon; Fiscal Year: 2013
    ..Furthermore, transgenesis would enable us to exploit the data from the imminent release of several sequenced hookworm genomes and transcriptomes for the development of novel hookworm control strategies. ..
  17. Neuromaturational Delays in Iron Deficient Anemic Infants
    Betsy Lozoff; Fiscal Year: 2013
    ..This study remains at the forefront of determining long-term brain and behavioral effects of IDA, its prevention in the healthy full-term human infant, and potential risks of providing iron to iron-sufficient infants. ..
  18. Role of insulin-like signaling in the hookworm infective process
    John M Hawdon; Fiscal Year: 2010
    ..This project will also provide insight into the basic molecular mechanisms operating during infection and the establishment of parasitic relationships that are relevant to other parasitic nematode infections of human significance. ..
  19. Genes that modify Iron loading in mice
    Nancy Catherine Andrews; Fiscal Year: 2012
    ..We have used animal models with inherited iron deficiency anemia to identify key components of iron transport pathways...
  20. THE ROLE OF ERYTHROPOIETIN RECEPTOR SIGNALING IN IRON DEFICIENCY ANEMIA
    Grant C Bullock; Fiscal Year: 2013
    ..on EpoR signaling using in vivo mouse models and physiologically relevant human cell culture models of iron deficiency anemia. Anemia affects the quality of life and the life expectancy of millions of people in the U.S...
  21. The effect of iron fortification of complementary foods on infant gut microbiota
    MICHAEL BRUCE ZIMMERMANN; Fiscal Year: 2011
    Infants and children <2 yrs are the age group with the highest rates of iron deficiency anemia. Provision of sufficient dietary iron to this age group is a challenge, and in-home iron fortification of complementary foods using ..
  22. Functional Testing of Conserved Regions in Eukaryotic Divalent Metal Transporters
    Lisa Ann Lambert; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Iron is an essential trace element: too little contributes to iron deficiency anemia, while too much iron can lead to organ damage and infection...
  23. Impact of host iron status on growth and viability of erythrocytic stages of Plas
    CARLA CERAMI HAND; Fiscal Year: 2011
    ..We will use RBC and sera from patients with severe iron deficiency anemia to look at this question in a very systematic way...
  24. Constraints on Visual Statistical Learning in Infancy
    Scott P Johnson; Fiscal Year: 2013
    ..Such an understanding may lead to assessment tools more closely tailored to early diagnosis and treatment than are presently available. ..
  25. H. PYLORI INFECTION AND GI DISEASE IN ALASKA NATIVES
    Douglas Berg; Fiscal Year: 2003
    ..Most striking is an Hp-associated hemorrhagic gastritis and iron deficiency anemia that is common only in Alaska Natives...
  26. The Molecular Pathogenesis of Hookworm Anemia
    Michael Cappello; Fiscal Year: 2005
    ..currently infected with blood feeding hookworms, intestinal nematodes that represent a leading cause of iron deficiency anemia in the world...
  27. The Molecular Pathogenesis of Hookworm Anemia
    Michael Cappello; Fiscal Year: 2001
    ..currently infected with blood feeding hookworms, intestinal nematodes that represent a leading cause of iron deficiency anemia in the world...
  28. EFFECTS OF ALCOHOL ON IRON HOMEOSTASIS
    Barry Potter; Fiscal Year: 1991
    ..and alcoholic liver disease are often associated with disturbances to iron homeostasis, ranging from iron deficiency anemia to hemochromatosis and siderosis...
  29. IRON DEFICIENCY ANEMIA AND COMPENSATORY SNS ACTIVITY
    John Beard; Fiscal Year: 1991
    ..is to define the relationships of catecholamine metabolism to decreased thermoregulatory capacity in iron deficiency anemia. The major hypothesis being tested is that increased SNS activity in iron deficiency is compensatory to ..
  30. Intestinal Iron Transport in Iron Deficiency/Anemia
    James Collins; Fiscal Year: 2005
    ..There is a well-known link between copper and iron homeostasis as copper deficiency causes anemia and iron deficiency anemia leads to increased body copper levels...
  31. INHIBITION OF INTESTINAL HEME IRON ABSORPTION
    JERRY BOMMER; Fiscal Year: 2007
    ..E) We will explore the drug's mechanism of action. (F) We will induce iron deficiency anemia in dogs by use of the inhibitor...
  32. IMPORTANT FACTORS IN THE REGULATION OF IRON ABSORPTION
    RICHARD TOPHAM; Fiscal Year: 1992
    ..as the ones in this proposal will provide insight into the molecular bases of metabolic disorders such as iron deficiency anemia, one of the most common deficiency states in humans, and hemochromatosis, the excess storage of iron, ..
  33. Study of Ferroportin 1 in mammalian iron homeostasis
    Adriana Donovan; Fiscal Year: 2006
    ..models could help us to better understand and treat diseases of iron homeostasis such as hemochromatosis, iron deficiency anemia and the anemia of chronic disease...
  34. Hepcidin Expression in the Anemia of Chronic Disease
    David Weinstein; Fiscal Year: 2007
    ..Improved understanding of the pathophysiology of the anemia of chronic disease will lay the foundation for new treatments for anemia and disorders of iron homeostasis. ..
  35. A Test of Iron Malabsorption in Patients with IDA
    Morteza Janghorbani; Fiscal Year: 2005
    b>Iron deficiency anemia (IDA) is a major problem among adults and elderly. In men and postmenopausal women, IDA is currently thought to result from gastrointestinal (GI) blood loss...
  36. Zinc Protoporphyrin and the Cell Cycle in Neonatal Mice
    Phyllis Dennery; Fiscal Year: 2007
    ..This compound is synthesized at higher levels in conditions of iron deficiency anemia and lead intoxication...
  37. Stability of new, iron-replete total nutrient admixtures
    Deanna Nelson; Fiscal Year: 2005
    There has been little progress in the treatment of iron deficiency anemia using a parenteral nutrient (PN) admixture with lipids as a suitable drug delivery vehicle. Currently approved parenteral iron colloids (e.g...
  38. MURINE IRON METABOLISM MUTATION MICROCYTOSIS (MK)
    Mark Fleming; Fiscal Year: 2001
    ..Microcytosis (mk) is an autosomal recessive defect in murine iron acquisition which results in iron deficiency anemia, characterized by abnormalities in both intestinal and red cell iron uptake...
  39. Long-term Iron Needs of Renal Transplant Recipients
    Morteza Janghorbani; Fiscal Year: 2005
    ....
  40. MECHANISMS OF INTESTINAL IRON ABSORPTION
    Matthias Hediger; Fiscal Year: 2004
    ....
  41. Metalloreductases in Medicine
    Mark Fleming; Fiscal Year: 2007
    ..the major erythroid transferrin cycle endosomal ferrireductase, SteapS, by positionally cloning the mouse iron deficiency anemia mutant nm1054...
  42. CLONING AND EXPRESSION OF THE HOOKWORM ANTICOAGULANT
    Michael Cappello; Fiscal Year: 1999
    ..Human hookworm infection is characterized by chronic GI bleeding and iron deficiency anemia. The adult worm facilitates blood feeding through secretion of a potent anticoagulant called the Hookworm ..
  43. FUNCTIONAL SIGNIFICANCE OF EARLY IRON DEFICIENCY
    Betsy Lozoff; Fiscal Year: 2008
    ..The long-range goal is to understand the behavioral and developmental effects of iron deficiency in infancy. Iron deficiency anemia affects one in 4-5 of the world's babies, and iron deficiency without anemia affects many more...
  44. IRON DEFICIENCY: BRAIN IRON/BEHAVIOR DURING DEVELOPMENT
    Barbara Felt; Fiscal Year: 2000
    The purpose of the proposed FIRST project is to determine the effects of iron deficiency anemia (IDA) and iron treatment during brain development on brain iron concentration, regional brain iron localization, aspects of neurotransmission ..
  45. nm1054: a new murine iron deficiency anemia mutant
    Mark Fleming; Fiscal Year: 2006
    ..We expect that determining which of the deleted genes is responsible for the anemia will provide insight into the pathway of iron delivery and utilization in mammalian cells. ..
  46. CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIA
    Chaim Hershko; Fiscal Year: 2001
    ..abstract_text> ..
  47. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  48. Heavy Metal Exposures in Women and Children, the Role of Nutrients
    Rebecca Stoltzfus; Fiscal Year: 2007
    ..The symposium will result in proceedings published in the Journal of Nutrition, one of the most widely read nutrition publications. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  50. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
  51. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....
  52. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2005
    ....
  53. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..the cumulative incidence of anemia is 100 percent among HIV-infected female injection drug users, and that iron deficiency anemia accounts for about half of the anemia...
  54. IRON DEFICIENCY AND DOPAMINE
    John Beard; Fiscal Year: 2004
    The principal long-term goal of this research is to determine the extent to which iron deficiency anemia (IDA)in early life leads to changes in monoamine biology with related changes in behavior...
  55. Behavioral factors and dietary change in WHTFSMP
    Alok Bhargava; Fiscal Year: 2003
    ..Overall, the results will facilitate the design of policies for improving health of especially minority women in the United States and will be useful for analyses of the Women's Health Initiative data. ..
  56. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2010
    ..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..