hyperuricemia

Summary

Summary: Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.

Top Publications

  1. pmc Uric acid and cardiovascular risk
    Daniel I Feig
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 359:1811-21. 2008
  2. ncbi Hyperuricemia induces endothelial dysfunction
    Uday M Khosla
    Baylor College of Medicine, Department of Medicine, Division of Nephrology, Houston, Texas 77030, USA
    Kidney Int 67:1739-42. 2005
  3. ncbi Uric acid and the development of hypertension: the normative aging study
    Todd S Perlstein
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hypertension 48:1031-6. 2006
  4. ncbi Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    Yui Pong Siu
    Division of Nephrology, Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Am J Kidney Dis 47:51-9. 2006
  5. pmc Effect of allopurinol in chronic kidney disease progression and cardiovascular risk
    Marian Goicoechea
    Servicio de Nefrologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin J Am Soc Nephrol 5:1388-93. 2010
  6. ncbi Pathogenesis of gout
    Hyon K Choi
    Arthritis Research Centre of Canada, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Intern Med 143:499-516. 2005
  7. ncbi Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
  8. ncbi Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008
    Yanyan Zhu
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:3136-41. 2011
  9. pmc Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome
    Ruth Belostotsky
    Division of Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel
    Am J Hum Genet 88:193-200. 2011
  10. ncbi Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence
    Johan Sundstrom
    The Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Hypertension 45:28-33. 2005

Detail Information

Publications320 found, 100 shown here

  1. pmc Uric acid and cardiovascular risk
    Daniel I Feig
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 359:1811-21. 2008
  2. ncbi Hyperuricemia induces endothelial dysfunction
    Uday M Khosla
    Baylor College of Medicine, Department of Medicine, Division of Nephrology, Houston, Texas 77030, USA
    Kidney Int 67:1739-42. 2005
    b>Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction...
  3. ncbi Uric acid and the development of hypertension: the normative aging study
    Todd S Perlstein
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hypertension 48:1031-6. 2006
    ..01 to 1.12; P=0.03). The baseline serum uric acid level is a durable marker of risk for the development of hypertension. The association is independent of elements of the metabolic syndrome, alcohol intake, and renal function...
  4. ncbi Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    Yui Pong Siu
    Division of Nephrology, Department of Medicine, Tuen Mun Hospital, Hong Kong, China
    Am J Kidney Dis 47:51-9. 2006
    b>Hyperuricemia is associated strongly with the development of hypertension, renal disease, and progression. Allopurinol decreases serum uric acid levels by inhibiting the enzyme xanthine oxidase...
  5. pmc Effect of allopurinol in chronic kidney disease progression and cardiovascular risk
    Marian Goicoechea
    Servicio de Nefrologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin J Am Soc Nephrol 5:1388-93. 2010
    b>Hyperuricemia is associated with hypertension, inflammation, renal disease progression, and cardiovascular disease. However, no data are available regarding the effect of allopurinol in patients with chronic kidney disease.
  6. ncbi Pathogenesis of gout
    Hyon K Choi
    Arthritis Research Centre of Canada, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Intern Med 143:499-516. 2005
  7. ncbi Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
    b>Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for this association...
  8. ncbi Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008
    Yanyan Zhu
    Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Arthritis Rheum 63:3136-41. 2011
    To estimate the prevalence of gout and hyperuricemia based on the latest nationally representative sample of US men and women (National Health and Nutrition Examination Survey [NHANES] 2007-2008).
  9. pmc Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome
    Ruth Belostotsky
    Division of Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel
    Am J Hum Genet 88:193-200. 2011
    ..The most significant clinical findings were tubulopathy (hyperuricemia, metabolic alkalosis), pulmonary hypertension, and progressive renal failure in infancy (HUPRA syndrome)...
  10. ncbi Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence
    Johan Sundstrom
    The Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Hypertension 45:28-33. 2005
    ..02) and diastolic pressure 4 years later (P=0.04). In summary, serum UA level was an independent predictor of hypertension incidence and longitudinal BP progression at short-term follow-up in our community-based sample...
  11. ncbi Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes: a 15-year follow-up study
    Eswar Krishnan
    Department of Medicine, School of Medicine, Stanford University, Palo Alto, California, USA
    Am J Epidemiol 176:108-16. 2012
    The objective of this study was to assess the utility of hyperuricemia as a marker for diabetes and prediabetes (impaired fasting glucose) and insulin resistance in young adults...
  12. ncbi Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University Hospital of the Ryukyus, Okinawa, Japan
    Am J Kidney Dis 44:642-50. 2004
    ..However, epidemiological evidence for the significance of serum uric acid levels on the risk for developing end-stage renal disease (ESRD) is scarce in a setting of community-based screening...
  13. ncbi A role for uric acid in the progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:2888-97. 2002
    b>Hyperuricemia is associated with renal disease, but it is usually considered a marker of renal dysfunction rather than a risk factor for progression...
  14. ncbi High serum uric acid as a novel risk factor for type 2 diabetes
    Abbas Dehghan
    Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P O Box 2040, 3000 CA Rotterdam, Netherlands
    Diabetes Care 31:361-2. 2008
    ..To investigate the association between serum uric acid level and risk of type 2 diabetes...
  15. pmc Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    JAMA 300:924-32. 2008
    b>Hyperuricemia is a predictor for the development of hypertension and is commonly present in new-onset essential hypertension...
  16. ncbi Association of hyperuricemia with renal outcomes, cardiovascular disease, and mortality
    Wan Chun Liu
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Taiwan
    Clin J Am Soc Nephrol 7:541-8. 2012
    b>Hyperuricemia is an independent risk factor for mortality, cardiovascular disease, and renal disease in general population. However, the relationship between hyperuricemia with clinical outcomes in CKD remains controversial.
  17. pmc EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 65:1312-24. 2006
    ..To develop evidence based recommendations for the management of gout...
  18. pmc Decreased extra-renal urate excretion is a common cause of hyperuricemia
    Kimiyoshi Ichida
    Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachiouji, Tokyo 192 0392, Japan
    Nat Commun 3:764. 2012
    ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which raises gout/hyperuricemia risk...
  19. ncbi Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
    Yuri Y Sautin
    Division of Nephrology, Hypertension, and Transplantation, Dept of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Cell Physiol 293:C584-96. 2007
    ..Collectively, our results suggest that hyperuricemia induces redox-dependent signaling and oxidative stress in adipocytes...
  20. pmc Uric acid transport and disease
    Alexander So
    Service de Rhumatologie, Department of Musculoskeletal Medicine, University of Lausanne, Lausanne, Switzerland
    J Clin Invest 120:1791-9. 2010
    ..b>Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent ..
  21. pmc The relationship between serum uric acid level and metabolic syndrome: differences by sex and age in Taiwanese
    Wen Ko Chiou
    Department of Industrial Design, Chang Gung University, Kweishan, Taoyuan, Taiwan, ROC
    J Epidemiol 20:219-24. 2010
    Metabolic syndrome (MetS) and hyperuricemia are important risk factors for cardiovascular disease. However, findings regarding the relationship between serum uric acid (UA) level and components of MetS have been inconsistent...
  22. ncbi Prevalence of the metabolic syndrome in individuals with hyperuricemia
    Hyon K Choi
    Rheumatology Division, Arthritis Research Centre of Canada, Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada
    Am J Med 120:442-7. 2007
    The link between hyperuricemia and insulin resistance has been noted, but the prevalence of the metabolic syndrome by recent definitions among individuals with hyperuricemia remains unclear...
  23. pmc Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy
    T C Hart
    University of Pittsburgh, School of Dental Medicine, Division of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Med Genet 39:882-92. 2002
    ..Genetic linkage studies have localised genes for both conditions to overlapping regions of chromosome 16p11-p13. These clinical and genetic findings suggest that these conditions may be allelic...
  24. pmc Uric acid and long-term outcomes in CKD
    Magdalena Madero
    Department of Medicine, Division of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Am J Kidney Dis 53:796-803. 2009
    b>Hyperuricemia is prevalent in patients with chronic kidney disease (CKD); however, data are limited about the relationship of uric acid levels with long-term outcomes in this patient population.
  25. ncbi Relationships among hyperuricemia, endothelial dysfunction and cardiovascular disease: molecular mechanisms and clinical implications
    Paolo Puddu
    Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna and S Orsola Malpighi Hospital, Bologna, Italy
    J Cardiol 59:235-42. 2012
    ..The simultaneous reduction in uric acid levels might contribute to these effects, or be a mere epiphenomenon of the drug action. The molecular mechanisms involved are discussed...
  26. ncbi J-shaped mortality relationship for uric acid in CKD
    Mohamed E Suliman
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 48:761-71. 2006
    b>Hyperuricemia is a common feature in patients with chronic kidney disease (CKD)...
  27. ncbi The effect of mild hyperuricemia on urinary transforming growth factor beta and the progression of chronic kidney disease
    Khaled M Talaat
    Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    Am J Nephrol 27:435-40. 2007
    Although mild hyperuricemia is common in patients with renal disease, it has usually been considered a marker of reduced nephron mass rather than a risk factor for progression of kidney disease...
  28. ncbi Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions
    Mehmet Kanbay
    35 Sokak, 81 5, Bahcelievler, Ankara, 06490, Turkey
    Int Urol Nephrol 39:1227-33. 2007
    b>Hyperuricemia has been associated with the development of hypertension, cardiovascular, and renal disease...
  29. ncbi Metabolic syndrome, diabetes, and hyperuricemia
    Changgui Li
    Shandong Provincial Key Laboratory of Metabolic Diseases, Qingdao Key Laboratory of Common Diseases Gout Laboratory, the Affiliated Hospital of Medical College, Qingdao University, China
    Curr Opin Rheumatol 25:210-6. 2013
    To explore the causal relationship between metabolic syndrome, type 2 diabetes and hyperuricemia.
  30. pmc Hyperuricemia and incident hypertension: a systematic review and meta-analysis
    Peter C Grayson
    Division of Rheumatology, Boston University Medical Center and Boston University, Boston, Massachusetts 02118, USA
    Arthritis Care Res (Hoboken) 63:102-10. 2011
    ..We conducted a systematic review and meta-analysis to determine if hyperuricemia was associated with incident hypertension, particularly in various demographic subgroups.
  31. ncbi Long-term cardiovascular mortality among middle-aged men with gout
    Eswar Krishnan
    Division of Rheumatology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Arch Intern Med 168:1104-10. 2008
    ..There are limited data available on the association of gouty arthritis (gout) in middle age with long-term cardiovascular disease (CVD) mortality...
  32. pmc The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial
    Michael A Becker
    The University of Chicago Pritzker School of Medicine, MC0930, University of Chicago Medical Center, 5841 S, Maryland Avenue, Chicago, IL 60637, USA
    Arthritis Res Ther 12:R63. 2010
    ..The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) > or = 8.0 mg/dL in a six-month trial...
  33. pmc Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
    Owen M Woodward
    Department of Physiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:10338-42. 2009
    ..Our study completes the chain of evidence from association to causation and supports the common disease-common variant hypothesis in the etiology of gout...
  34. ncbi Role of uric acid in hypertension, renal disease, and metabolic syndrome
    Marcelo Heinig
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville 32610, USA
    Cleve Clin J Med 73:1059-64. 2006
    b>Hyperuricemia has long been known to be associated with cardiovascular disease, and it is particularly common in people with hypertension, metabolic syndrome, or kidney disease...
  35. ncbi Hyperuricemia and metabolic syndrome: associations with chronic kidney disease
    Lai Chu See
    Department of Public Health, Biostatistics Consulting Center, Chang Gung University, Tao Yuan, Taiwan, Republic of China
    Clin Rheumatol 30:323-30. 2011
    ..b>Hyperuricemia was defined as an SUA greater than 7.7 mg/dL in men or greater than 6.6 mg/dL in women...
  36. pmc Hyperuricemia and coronary heart disease: a systematic review and meta-analysis
    Seo Young Kim
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:170-80. 2010
    The role of serum uric acid as an independent risk factor for cardiovascular disease remains unclear, although hyperuricemia is associated with cardiovascular disease such as coronary heart disease (CHD), stroke, and hypertension.
  37. ncbi 2011 Recommendations for the diagnosis and management of gout and hyperuricemia
    Max Hamburger
    Rheumatology Associates of Long Island, Melville, NY 11747, USA
    Postgrad Med 123:3-36. 2011
    ..It is the objective of these 2011 recommendations for the diagnosis and management of gout and hyperuricemia to update the 2006 EULAR guidelines, paying special attention to the needs of primary care physicians, who ..
  38. ncbi Uric acid and the state of the intrarenal renin-angiotensin system in humans
    Todd S Perlstein
    Endocrinology, Diabetes and Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 66:1465-70. 2004
    Experimental hyperuricemia is marked by an activated intrarenal renin-angiotensin system (RAS). The renal vascular response to exogenous angiotensin II (Ang II) provides an indirect measure of intrarenal RAS activity...
  39. ncbi Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008
    Yanyan Zhu
    Clinical Epidemiology Unit, Boston University School of Medicine, MA, USA
    Am J Med 125:679-687.e1. 2012
    The objective of this study was to estimate the latest prevalence of major comorbidities associated with gout and hyperuricemia in the US based on a recent, nationally representative sample of US men and women.
  40. ncbi Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Aliment Pharmacol Ther 34:757-66. 2011
    b>Hyperuricemia has been associated with metabolic disorders. In this line recent studies observed an independent link between higher uric acid serum levels and clinical diagnosis of non-alcoholic fatty liver disease (NAFLD).
  41. ncbi Hyperuricemia and the echocardiographic measures of myocardial dysfunction
    Eswar Krishnan
    Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Congest Heart Fail 18:138-43. 2012
    Few studies have investigated the association between hyperuricemia and subclinical myocardial dysfunction...
  42. ncbi Gout and the risk of acute myocardial infarction
    Eswar Krishnan
    University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Arthritis Rheum 54:2688-96. 2006
    To determine if hyperuricemia and gouty arthritis are independent risk factors for acute myocardial infarction (MI) and, if so, whether they are independent of renal function, diuretic use, metabolic syndrome, and other established risk ..
  43. ncbi Hyperuricemia as a risk factor on cardiovascular events in Taiwan: The Chin-Shan Community Cardiovascular Cohort Study
    Kuo Liong Chien
    Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taipei, Taiwan
    Atherosclerosis 183:147-55. 2005
    ..The rate ratios of hyperuricemia ranged between 2.00 and 3.96, with higher risk ratios in women than in men...
  44. ncbi Inflammation, oxidative stress and lipids: the risk triad for atherosclerosis in gout
    Eswar Krishnan
    Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA
    Rheumatology (Oxford) 49:1229-38. 2010
    ..It is hoped that the introduction of newer urate-lowering agents may help to clarify this picture and improve treatment options for both gout and atherosclerosis...
  45. ncbi Joint association of hyperuricemia and reduced GFR on cardiovascular morbidity: a historical cohort study based on laboratory and claims data from a national insurance provider
    Luca Neri
    Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO, USA
    Am J Kidney Dis 58:398-408. 2011
    b>Hyperuricemia is common in patients with chronic kidney disease (CKD). We assessed the relationship of increased serum uric acid levels with cardiovascular risk across levels of kidney function.
  46. pmc Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome
    William Baldwin
    Department of Medicine, University of Florida, Gainesville, Florida, USA
    Diabetes 60:1258-69. 2011
    b>Hyperuricemia is strongly associated with obesity and metabolic syndrome and can predict visceral obesity and insulin resistance...
  47. ncbi Is high serum uric acid a risk marker or a target for treatment? Examination of its independent effect in a large cohort with low cardiovascular risk
    Chi Pang Wen
    Division of Health Policy Research and Development, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan
    Am J Kidney Dis 56:273-88. 2010
    ..Cohort studies evaluating increased uric acid level as a cardiovascular disease (CVD) risk factor have shown variable results; studies are particularly lacking in lower risk populations...
  48. pmc Hyperuricemia in childhood primary hypertension
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    Hypertension 42:247-52. 2003
    ..These results are consistent with the hypothesis that uric acid might have a role in the early pathogenesis of primary hypertension...
  49. pmc Hyperuricemia and risk of stroke: a systematic review and meta-analysis
    Seo Young Kim
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Arthritis Rheum 61:885-92. 2009
    To assess the association between hyperuricemia and risk of stroke incidence and mortality because hyperuricemia is hypothesized to be a risk factor for stroke and other cardiovascular disease, but, to date, results from observational ..
  50. pmc EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 65:1301-11. 2006
    ..To develop evidence based recommendations for the diagnosis of gout...
  51. ncbi Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610, USA
    Nat Clin Pract Nephrol 1:80-6. 2005
    ..As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and induces insulin resistance...
  52. ncbi Hyperuricemia and metabolic syndrome: lessons from a large cohort from Israel
    Eytan Cohen
    Recanati Center for Medicine and Research, Petah Tikva, Israel
    Isr Med Assoc J 14:676-80. 2012
    ..There is a striking increase in the number of people with metabolic syndrome (MetS) as a result of the global epidemic of obesity and diabetes. Increasing evidence suggests that uric acid may play a role in MetS...
  53. pmc Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial
    Yongjun Shi
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Kidney Blood Press Res 35:153-60. 2012
    b>Hyperuricemia is an independent risk factor for renal progression in IgA nephropathy (IgAN). However, no study has evaluated the effect of allopurinol on the clinical outcome in hyperuricemic IgAN.
  54. ncbi Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan
    Kazufumi Nagahama
    Department of Cardiovascular Medicine, Nephrology and Neurology, Faculty of Medicine, University of the Ryukyus, Nakagami gun, Okinawa, Japan
    Hypertens Res 27:835-41. 2004
    ..We prospectively examined the relation between hyperuricemia and the risk of developing hypertension with consideration for alcohol consumption and smoking habits in a ..
  55. ncbi Hyperuricemia as an independent risk factor of chronic kidney disease in middle-aged and elderly population
    Hung Yu Chang
    Department of Nephrology, Chang Gung Memorial Hospital, Chiayi, Taiwan
    Am J Med Sci 339:509-15. 2010
    b>Hyperuricemia in the general population remains controversial, in terms of it being considered a risk factor for chronic kidney disease (CKD)...
  56. ncbi Gender distribution of serum uric acid and cardiovascular risk factors: population based study
    Sérgio Lamêgo Rodrigues
    Departamento de Ciencias Fisiologicas, Universidade Federal do Espirito Santo, Brazil
    Arq Bras Cardiol 98:13-21. 2012
    There is no data concerning the epidemiology of hyperuricemia in Brazilian population-based studies.
  57. pmc Chronic hyperuricemia, uric acid deposit and cardiovascular risk
    Davide Grassi
    University of L Aquila Department of Internal Medicine and Public Health San Salvatore Hospital Italy
    Curr Pharm Des 19:2432-8. 2013
    b>Hyperuricemia is commonly associated with traditional risk factors such as dysglicemia, dyslipidemia, central obesity and abnormal blood pressure, i.e. the metabolic syndrome...
  58. ncbi Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging
    Stefan D Anker
    Applied Cachexia Research Unit, Charite, Campus Virchow Klinikum, Berlin, Germany
    Circulation 107:1991-7. 2003
    ..Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF)...
  59. ncbi Hyperuricemia and the progression of chronic kidney disease: is uric acid a marker or an independent risk factor?
    Khaled Nashar
    Division of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Adv Chronic Kidney Dis 19:386-91. 2012
    b>Hyperuricemia is seen when kidney function declines. Whether elevated uric acid (UA) levels play a role in the initiation and progression of kidney disease is a subject of a great debate...
  60. ncbi Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study
    Kazuhide Ogino
    Center for Clinical Residency Program, Tottori University Hospital, Yonago, Japan
    Circ Heart Fail 3:73-81. 2010
    b>Hyperuricemia is common in chronic heart failure (CHF), and it is a strong independent marker of prognosis...
  61. pmc The prevalence of hyperuricemia in China: a meta-analysis
    Liu B
    Jinan Institute of Cardiovascular Disease, The Fourth People s Hospital of Jinan, China
    BMC Public Health 11:832. 2011
    The prevalence of hyperuricemia varied in different populations and it appeared to be increasing in the past decades. Recent studies suggest that hyperuricemia is an independent risk factor for cardiovascular disease...
  62. pmc Hyperuricaemia, chronic kidney disease, and outcomes in heart failure: potential mechanistic insights from epidemiological data
    Gerasimos S Filippatos
    University of Athens, Athens, Greece
    Eur Heart J 32:712-20. 2011
    ..To determine if the association between hyperuricaemia and poor outcomes in heart failure (HF) varies by chronic kidney disease (CKD)...
  63. ncbi Effects of acute and chronic L-arginine treatment in experimental hyperuricemia
    Laura G Sanchez-Lozada
    Dept of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1 14080, Mexico City, Mexico
    Am J Physiol Renal Physiol 292:F1238-44. 2007
    Experimental hyperuricemia (HU) results in preglomerular arteriolopathy, cortical vasoconstriction, and glomerular hypertension. Recently, uric acid has been shown to induce endothelial dysfunction...
  64. ncbi Teriparatide in postmenopausal women with osteoporosis and mild or moderate renal impairment
    P D Miller
    Department of Medicine, University of Colorado Health Sciences Center and Colorado Center for Bone Research, Denver, CO, USA
    Osteoporos Int 18:59-68. 2007
    ..The prevalence of both osteoporosis and renal impairment increases with age...
  65. ncbi A cohort study of hyperuricemia in middle-aged South Korean men
    Seungho Ryu
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, 2024 East Monument Street, Baltimore, MD 21205, USA
    Am J Epidemiol 175:133-43. 2012
    Few prospective studies have assessed the incidence and determinants of asymptomatic hyperuricemia in free-living populations...
  66. ncbi Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery
    Robert W Powers
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 194:160. 2006
    We investigated changes in serum uric acid across pregnancy in women with gestational hyperuricemia at delivery, with and without preeclampsia, compared with normal pregnant and women with preeclampsia without gestational hyperuricemia.
  67. ncbi Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease
    Eun Sun Ryu
    Division of Nephrology, Department of Internal Medicine, Ewha Womans University School of Medicine, 911 Mok dong Yangcheon Ku, Seoul 158 710, Korea
    Am J Physiol Renal Physiol 304:F471-80. 2013
    ..Experimental hyperuricemia was associated with evidence of EMT before the development of significant tubulointerstitial fibrosis at 4 wk, ..
  68. ncbi Uric acid, heart failure survival, and the impact of xanthine oxidase inhibition
    Arash Harzand
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30312, USA
    Congest Heart Fail 18:179-82. 2012
    ....
  69. pmc The independent association between parathyroid hormone levels and hyperuricemia: a national population study
    Janet Y Hui
    The Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite 200, Boston, MA 02118, USA
    Arthritis Res Ther 14:R56. 2012
    Increased frequencies of hyperuricemia and gout have been associated with primary hyperparathyroidism, and recent clinical trials of parathyroid hormone (PTH) have reported hyperuricemic adverse events...
  70. ncbi New insights into uric acid effects on the progression and prognosis of chronic kidney disease
    Vassilis Filiopoulos
    Department of Nephrology, Amalia Fleming General Hospital, Athens, Greece
    Ren Fail 34:510-20. 2012
    b>Hyperuricemia is particularly common in patients with arterial hypertension, metabolic syndrome, or kidney disease...
  71. pmc Hyperuricemia and the risk for subclinical coronary atherosclerosis--data from a prospective observational cohort study
    Eswar Krishnan
    Department of Medicine, Stanford University School of Medicine, 1000 Welch Road, Suite 203, Palo Alto, CA 94304, USA
    Arthritis Res Ther 13:R66. 2011
    Our purpose was to test the hypothesis that hyperuricemia is associated with coronary artery calcification (CAC) among a relatively healthy population, and that the extent of calcification is directly proportional to the serum uric acid (..
  72. ncbi Serum uric acid levels in obese children and adolescents: linkage to testosterone levels and pre-metabolic syndrome
    Christian Denzer
    Department of Pediatrics, University of Ulm, Germany
    J Pediatr Endocrinol Metab 16:1225-32. 2003
    b>Hyperuricemia is part of the "metabolic syndrome". The aim of this study was to investigate the regulation and role of serum uric acid in the cardiovascular risk factor profile of obese children and adolescents...
  73. ncbi Relationships among hyperuricemia, metabolic syndrome, and endothelial function
    Hirofumi Tomiyama
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Am J Hypertens 24:770-4. 2011
    We evaluated the relationship of the severity of hyperuricemia and the flow-mediated vasodilatation of the brachial artery (FMD) in patients with and without the metabolic syndrome (MetS).
  74. ncbi Frequency, risk, and cost of gout-related episodes among the elderly: does serum uric acid level matter?
    Eric Q Wu
    Analysis Group, Inc, Boston, Massachusetts 02199, USA
    J Rheumatol 36:1032-40. 2009
    ..We examined the association between serum uric acid (SUA) level and the frequency, risk, and cost of gout flares among the elderly...
  75. ncbi Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement
    Qing Hua Hu
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Am J Physiol Renal Physiol 297:F1080-91. 2009
    Fructose consumption has been recently related to an epidemic of metabolic syndrome, and hyperuricemia plays a pathogenic role in fructose-induced metabolic syndrome...
  76. ncbi Uric acid: role in cardiovascular disease and effects of losartan
    Michael Alderman
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461 1602, USA
    Curr Med Res Opin 20:369-79. 2004
    ..Further, patients with hypertension and hyperuricemia have a 3- to 5-fold increased risk of experiencing coronary artery disease or cerebrovascular disease compared ..
  77. ncbi Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD)
    T R Mikuls
    Department of Medicine, Division of Clinical Immunology and Rheumatology, 510 20th Street South, FOT 8th Floor, Birmingham, AL 35294, USA
    Rheumatology (Oxford) 44:1038-42. 2005
    ..To examine adherence to validated quality indicators assessing the quality of allopurinol use in the treatment of gout and asymptomatic hyperuricaemia...
  78. ncbi Alterations of uromodulin biology: a common denominator of the genetically heterogeneous FJHN/MCKD syndrome
    P Vylet'al
    Center for Applied Genomics, Charles University 1st School of Medicine, Prague, Czech Republic
    Kidney Int 70:1155-69. 2006
    Autosomal dominant hyperuricemia, gout, renal cysts, and progressive renal insufficiency are hallmarks of a disease complex comprising familial juvenile hyperuricemic nephropathy and medullary cystic kidney diseases type 1 and type 2...
  79. ncbi Prevalence of hyperuricemia and its relationship with metabolic syndrome in Thai adults receiving annual health exams
    Vitool Lohsoonthorn
    Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Arch Med Res 37:883-9. 2006
    Associations between hyperuricemia, metabolic syndrome, cardiovascular disease and diabetes have been reported. Limited information, however, is available concerning the prevalence and correlates of hyperuricemia among Thai men and women...
  80. ncbi Relationship between hyperuricemia (HUC) and metabolic syndrome (MS) in institutionalized elderly men
    Chung Hsin Chang
    Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, No 160, Sec 3, Chung Kang Rd, Taichung, 40705 Taiwan, R O C
    Arch Gerontol Geriatr 49:S46-9. 2009
    This study investigated the relationship between hyperuricemia (HUC) and the components of the metabolic syndrome (MS) among elderly institutionalized men...
  81. ncbi PEG-uricase in the management of treatment-resistant gout and hyperuricemia
    MERRY R SHERMAN
    Mountain View Pharmaceuticals, Inc, 3475 S Edison Way, Menlo Park, CA 94025, USA
    Adv Drug Deliv Rev 60:59-68. 2008
    b>Hyperuricemia results from an imbalance between the rates of production and excretion of uric acid...
  82. ncbi Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men
    Sachiko Tamba
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Intern Med 47:1175-80. 2008
    ..Hypoadiponectinemia is one of the key molecules of the MetS. In the present study, we investigated the relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men...
  83. pmc Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25
    Li Shu Chuan Cheng
    Division of Information Science, City of Hope Medical Center, Duarte, CA, USA
    Am J Hum Genet 75:498-503. 2004
    ..The Pacific Austronesian population, including Taiwanese aborigines, has a remarkably high prevalence of hyperuricemia and gout, which suggests a founder effect across the Pacific region...
  84. pmc Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia
    Sirirat Reungjui
    Division of Nephrology, Khon Kaen University, Khon Kaen, Thailand
    Curr Opin Nephrol Hypertens 17:470-6. 2008
    ..are to review the current controversies related to the use of thiazide diuretics as first-line treatment of hypertension and to discuss the causal roles for hyperuricemia and hypokalemia on the adverse consequences of thiazide usage.
  85. pmc Uric acid, hyperuricemia and vascular diseases
    Ming Jin
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Front Biosci (Landmark Ed) 17:656-69. 2012
    Uric acid is the product of purine metabolism. It is known that hyperuricemia, defined as high levels of blood uric acid, is the major etiological factor of gout...
  86. ncbi Hyperuricemia and gout in renal transplant recipients
    Mohammad Abdelrahman
    Nephrology Department, Kanoo Kidney Center, Dammam Central Hospital, Saudi Arabia
    Ren Fail 24:361-7. 2002
    b>Hyperuricemia, unlike clinical gout, is extremely common in renal transplant patients. The high prevalence of hyperuricemia is related to prolonged exposure to cyclosporine rather than to its dose or serum concentration...
  87. pmc Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome
    Shuzo Takayama
    Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime 791 0295, Japan
    Cardiovasc Diabetol 11:2. 2012
    ..Associations between uric acid (UA), metabolic syndrome (MetS) and carotid IMT have been reported, but findings regarding the relationship have been inconsistent...
  88. pmc Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure
    Martina Zivná
    Center for Applied Genomics, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic
    Am J Hum Genet 85:204-13. 2009
    ..three unrelated families with the autosomal-dominant inheritance of early onset anemia, hypouricosuric hyperuricemia, progressive kidney failure, and mutations resulting either in the deletion (p...
  89. pmc Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet 372:1953-61. 2008
    ..Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout...
  90. ncbi Epidemiological association between uric acid concentration in plasma, lipoprotein(a), and the traditional lipid profile
    Giuseppe Lippi
    Section of Clinical Chemistry, University of Verona Medical School, Verona, Italy
    Clin Cardiol 33:E76-80. 2010
    ..It is unclear whether they are independent risk factors or simply markers, reflecting association with other traditional risk factors...
  91. ncbi Renal function in gout: long-term treatment effects of febuxostat
    Andrew Whelton
    Universal Clinical Research Center, Inc, 1737 Beaver Brook Lane, Hunt Valley, MD 21030 1603, USA
    J Clin Rheumatol 17:7-13. 2011
    The association between hyperuricemia, gout, and impaired renal function has long been recognized...
  92. ncbi Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort
    Shao Yuan Chuang
    Institute of Population Health Sciences, National Health Research Institutes, Miaoli Country, Taiwan
    Int J Cardiol 154:316-21. 2012
    ..We investigated whether such a relation exists for ethnic Chinese with low CVD risk...
  93. ncbi Febuxostat: a selective xanthine-oxidase/xanthine-dehydrogenase inhibitor for the management of hyperuricemia in adults with gout
    Michael E Ernst
    Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Ther 31:2503-18. 2009
    Febuxostat, a nonpurine selective inhibitor of both the oxidized and reduced forms of xanthine oxidase, was approved in February 2009 by the US Food and Drug Administration for the management of hyperuricemia in adults with gout.
  94. ncbi Prognostic significance of hyperuricemia in patients with different types of renal dysfunction and acute myocardial infarction treated with percutaneous coronary intervention
    Jacek Kowalczyk
    Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze, Poland
    Nephron Clin Pract 116:c114-22. 2010
    This study evaluated the impact of hyperuricemia (HUR) on outcome in patients with different types of impaired renal function (IRF) and acute myocardial infarction (AMI) treated invasively.
  95. ncbi Dietary factors associated with hyperuricemia in adults
    Kuang Hui Yu
    Division of Rheumatology, Chang Gung Memorial Hospital, Chang Gung University, Tao Yuan, Taiwan, Republic of China
    Semin Arthritis Rheum 37:243-50. 2008
    Although diet has long been assumed to be associated with hyperuricemia, the association between diet and hyperuricemia remains to be verified.
  96. ncbi Is uric acid a predictive factor for graft dysfunction in renal transplant recipients?
    A Akgul
    Department of Nephrology, Baskent University Hospital, Ankara, Turkey
    Transplant Proc 39:1023-6. 2007
    b>Hyperuricemia is a common complication in renal transplant recipients, and uric acid (UA) may play a role in renal dysfunction...
  97. ncbi Uric acid and transplantation
    Marilda Mazzali
    Division of Nephrology, Universidade Estadual de Campinas, UNICAMP, Campinas SP, Brazil
    Semin Nephrol 25:50-5. 2005
    b>Hyperuricemia is a common complication in organ transplant recipients, and frequently is associated with chronic cyclosporine immunosuppressive therapy...
  98. ncbi The impact of hyperuricemia on in-hospital mortality and incidence of acute kidney injury in patients undergoing percutaneous coronary intervention
    Sang Ho Park
    Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
    Circ J 75:692-7. 2011
    There is very little information about the relationship between hyperuricemia, acute kidney injury (AKI) and in-hospital mortality.
  99. pmc Sugar-sweetened soda consumption, hyperuricemia, and kidney disease
    Andrew S Bomback
    Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Kidney Int 77:609-16. 2010
    ..Here we determined whether soda drinking is associated with hyperuricemia and, as a potential consequence, reduced kidney function...
  100. ncbi Primary prevention in rheumatology: the importance of hyperuricemia
    Janitzia Vazquez-Mellado
    Rheumatology Service, Hospital General de Mexico, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, Dr Balmis 148, Col Doctores, 06726 Mexico City, Mexico
    Best Pract Res Clin Rheumatol 18:111-24. 2004
    b>Hyperuricemia (HU) is present in 5-30% of the general population, although the prevalence is higher among some ethnic groups and seems to be increasing worldwide...
  101. ncbi Effect of prophylaxis on gout flares after the initiation of urate-lowering therapy: analysis of data from three phase III trials
    Robert L Wortmann
    Section of Rheumatology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Clin Ther 32:2386-97. 2010
    ..therapy (ULT), such as febuxostat or allopurinol, is recommended for the long-term management of hyperuricemia in patients with gout to reduce the incidence of acute flares...

Research Grants62

  1. Central Biochemistry Laboratory of the CKiD Consortium
    George J Schwartz; Fiscal Year: 2013
    ..The CBL has submitted concept sheets to further determine if hyperuricemia predicts renal progression or hypertension, if microalbuminuria is a better predictor of renal progression ..
  2. Impact of Cardiovascular and Weight Loss diets on Uric Acid and Gout Risk
    Hyon K Choi; Fiscal Year: 2013
    Gout is a common and excruciatingly painful inflammatory arthritis associated with hyperuricemia. Gout represents a metabolically-driven arthropathy that could be substantially controlled through dietary and lifestyle modifications...
  3. A Novel Approach to Phosphorus Lowering in Patients with Chronic Kidney Disease
    Joachim H Ix; Fiscal Year: 2013
    ..Unlike niacin, it does not cause flushing, liver test abnormalities, hyperuricemia, or insulin resistance...
  4. Comprehensive SNP Discovery in SLC2A9. A Candidate Gene for Uric Acid Nephropathy
    Venkata Saroja Voruganti; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Increased serum uric acid (SUA) or hyperuricemia is a metabolic problem that is associated with increased renal disease risk and has been increasing in prevalence worldwide...
  5. PROINFLAMMATORY ROLE OF URIC ACID IN LUNG DISEASE: NOVEL MODELS AND CLINICAL VALI
    Richard M Wright; Fiscal Year: 2013
    ..2) To determine whether serum UA contributes to ALI/ARDS in a genetic model of hyperuricemia we will knockout hepatocyte XOR in Leprdb-lb mice that will be treated with hepatocyte targeted anti-XOR-shRNA ..
  6. Uric Acid, Vitamin C and Bone Health: The Framingham Study
    Shivani Sahni; Fiscal Year: 2013
    ..However, at elevated levels (hyperuricemia), uric acid may act as a prooxidant and contribute to inflammation...
  7. Patient Centered Outcomes Research in Rheumatology
    DANIEL HAL SOLOMON; Fiscal Year: 2013
    ..Finally, Aim 2c will investigate the potential role of UALT on CVD outcomes. Strong epidemiologic data link hyperuricemia with CVD, but there have been no large studies examining whether treatments such as allopurinol, febuxostat, ..
  8. ROLE OF TAMM-HORSFALL PROTEIN IN URINARY TRACT DEFENSE
    Xue ru Wu; Fiscal Year: 2013
    ..we found that the transgenic mice expressing a THP mutation exhibit marked defects in tubular function and hyperuricemia. Importantly, the intra-renal calcification and hyperuricemia observed in our mouse models bear striking ..
  9. Natural Substance Derivative DHNB is A Novel Xanthine Oxidase Inhibitor
    Changyi Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gout is caused by hyperuricemia, which is an abnormally high level of uric acid in the blood. Gout prevalence is about 3.9% for general population...
  10. Structure/activity studies of two molybdenum enzymes
    Russ Hille; Fiscal Year: 2009
    ..two steps in purine metabolism in humans, and is also an important therapeutic target in the treatment of hyperuricemia and also in chemotherapeutic regimens...
  11. Centers of Research Translation (CoRT)
    Kenneth G Saag; Fiscal Year: 2013
    ..The role of genetic factors on gout and hyperuricemia among different races/ethnicities and the mechanisms by which treatment of hyperuricemia may impact vascular ..
  12. Systems Biology of Anionic Drug and Metabolite Handling
    Sanjay K Nigam; Fiscal Year: 2012
    ..The ultimate goal is to set the stage for a model with predictive power in the clinical contexts of complex metabolic disease phenotypes (eg. hyperuricemia) and pharmacogenomics.
  13. Risk Factors for Gout Among Women
    Hyon Choi; Fiscal Year: 2009
    ..provided by applicant): Gout is a common and excruciatingly painful inflammatory arthritis associated with hyperuricemia. The condition represents an important type of arthritis that may be substantially controlled through dietary ..
  14. Uric Acid and Risk of Chronic Kidney Disease Progression
    MATTHEW GARRETT DENKER; Fiscal Year: 2013
    ..The role of hyperuricemia in CKD progression is controversial, with conflicting results from observational studies...
  15. MOLECULAR MECHANISMS OF PRPP-SYNTHETASE OVERACTIVITY
    Blake Roessler; Fiscal Year: 1991
    ..Supernormal activity of PRPP-synthtase in erythrocytes is assoicated with an X-linked syndrome consisiting of hyperuricemia, hyperuricaciduria, precocious gout and nephrolithiasis...
  16. MOLECULAR MECHANISMS OF PRPP-SYNTHETASE OVERACTIVITY
    THOMAS PALELLA; Fiscal Year: 1990
    ..Supernormal activity of PRPP-synthtase in erythrocytes is assoicated with an X-linked syndrome consisiting of hyperuricemia, hyperuricaciduria, precocious gout and nephrolithiasis...
  17. Lesch-Nyhan disease: dissecting the functions of HGprt
    HYDER JINNAH; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Lesch-Nyhan disease (LND) is a neurogenetic disorder characterized by hyperuricemia and a characteristic neurobehavioral syndrome...
  18. Inosine in the over-the-counter treatment of MS
    DOUGLAS HOOPER; Fiscal Year: 2004
    ..that MS patients most often have lower serum UA levels than age- and sex- matched healthy controls and gout (hyperuricemia) patients rarely, if ever, develop MS...
  19. ARRAY SCREENING FOR LESCH NYHAN DISEASE
    Theodore Friedmann; Fiscal Year: 2002
    ..The disorder includes mental retardation, hyperuricemia, choreoathetosis and involuntary and compulsive self-mutilation...
  20. GENETIC ALTERATIONS IN LESCH-NYHAN DISEASE
    C Caskey; Fiscal Year: 1992
    ..which is characterized by mental retardation, choreoathetosis, self mutilating behavior, and hyperuricemia. A wide variety of mutations at the HPRT locus has been described in patients with this clinical phenotype...
  21. Genotype and Phenotype of Familial Nephropathy with Gout
    Mary Marazita; Fiscal Year: 2005
    ..of interstitial kidney disease and chronic renal failure, and (c) help to better define relationships between hyperuricemia, uric acid excretion, and the development of renal failure...
  22. Primary Prevention of Hypertension in Obese Adolescents
    Daniel Feig; Fiscal Year: 2006
    ..In our animal model, hyperuricemia induces hypertension in rats that has all of the clinico-pathologic characteristics of essential hypertension...
  23. Uric Acid in Childhood Hypertension
    Daniel Feig; Fiscal Year: 2007
    An association between hyperuricemia and hypertension has been observed repeatedly since the 1870s...
  24. REGULATION OF PURINE NUCLEOTIDE SYNTHESIS IN HUMANS
    Michael Becker; Fiscal Year: 2001
    ....
  25. Uric Acid and Hypertension in African-Americans
    Mark Segal; Fiscal Year: 2008
    ..provided by applicant): Thiazide diuretics are associated with many metabolic side effects including hyperuricemia, gout, insulin resistance, and hyperlipidemia...
  26. PTHRP 1 to 173 IN CHONDROCYTES
    Robert Terkeltaub; Fiscal Year: 2005
    ..Completion of these studies will indicate not only how PTHrP 1-173 can modulate OA, but also how functional properties of the PTHrP 1-173 C-terminal 140-173 domain can be harnessed to promote cartilage repair. ..
  27. ANK and Joint Ankylosis in Spondylitis
    Robert Terkeltaub; Fiscal Year: 2008
    ..These studies will identify novel targets for enthesopathic bone fusion in spondyloarthritis. ..
  28. Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    Robert Terkeltaub; Fiscal Year: 2009
    ..Completion of the work will reveal new potential targets for therapeutic intervention in OA by disconnecting inflammation from deleterious alteration of chondrocyte differentiation and function. ..
  29. The molecular basis for an animal model of inherited hyperuricosuria
    Danika Bannasch; Fiscal Year: 2007
    ..Thus, the Dalmatian is a natural model for the human conditions hyperuricosuria and hyperuricemia (i.e., elevated levels of uric acid in the urine and blood, respectively)...
  30. FORMULATION OF RATIONAL THERAPY OF NEPHROLITHIASIS
    Orson Moe; Fiscal Year: 2008
    ..This proposal will address the nature of calcium-oxalate interaction and how it impacts on the risk of developing kidney stones. ..
  31. NEUROBIOLOGY OF DYSTONIA
    HYDER JINNAH; Fiscal Year: 2008
    ..In addition, the studies will have direct relevance for modern neurosurgical approaches to the management of dystonia that involve focal brain stimulation or lesion techniques. [unreadable] [unreadable]..
  32. Risk Factors for Decline in Renal Function
    Gary Curhan; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  33. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2009
    ..Our proposal will advance understanding of the role of vascular growth factors in initiating and promoting vascular stiffness, LV dysfunction and HTN. ..
  34. Ventricular Vascular Coupling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2009
    ..LV and vascular stiffness measures at prior examinations facilitate the evaluation of longitudinal changes and associated risk. ..
  35. ENDOGENOUS AND EXOGENOUS IL 10 AND RENAL INJURY
    Orson Moe; Fiscal Year: 2001
    ....
  36. H+-ATPase B-subunit Dysfunction and Calcium Nephrolithiasis
    Orson W Moe; Fiscal Year: 2010
    ....
  37. Aldosterone in Vascular Remodeling and Dysfunction
    Vasan Ramachandran; Fiscal Year: 2008
    ..Activities for career development of the candidate are also planned in the areas of proteomics and genetic epidemiology. ..
  38. Molecular Physiology of Renal K-Cl Cotransporters
    David Mount; Fiscal Year: 2007
    ..abstract_text> ..
  39. Chronic Kidney Disease with Benign Prostatic Hyperplasia
    ANDREW RULE; Fiscal Year: 2004
    ..Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD. ..
  40. Ventricular Matrix Remodeling: Correlates and Prognosis
    Vasan Ramachandran; Fiscal Year: 2004
    ..The proposed translational research will likely yield seminal information that could directly improve our efforts to prevent CHF through the biochemical assessment of cardiac ECM remodeling. ..
  41. First Int'l Symposium on Childhood and Adolescent NHL
    Mitchell Cairo; Fiscal Year: 2003
    ..abstract_text> ..
  42. Nonablative AlloSCT in Refractory Autoimmune Disease
    Mitchell Cairo; Fiscal Year: 2003
    ....
  43. Genetics of Oxidative Stress in Ventricular Remodeling
    Vasan Ramachandran; Fiscal Year: 2003
    ....
  44. ANALGESIC USE AND THE RISK OF CHRONIC RENAL FAILURE
    Gary Curhan; Fiscal Year: 2002
    ....
  45. PEGylated Prolactin Receptor Antagonists as Cancer Drugs
    MERRY SHERMAN; Fiscal Year: 2002
    ..Tumor growth or shrinkage will be monitored non-invasively, using tumors derived from cells transfected to contain luciferase, in collaboration with Robert S. Negrin...
  46. Preclinical Development of Uricase-PEG 20
    JOHN BOMALASKI; Fiscal Year: 2002
    b>Hyperuricemia (elevated serum uric acid) results in gouty arthritis and chronic renal disease...
  47. MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATION
    Charles Lieber; Fiscal Year: 2001
    ..Such information is aimed at elucidating key aspects of alcohol mediated pathology in a way which may eventually affect alcohol related medical complications, their prevention and treatment. ..
  48. Acute Regulation of the Renal Na/H Exchanger NHE-3
    Orson Moe; Fiscal Year: 2005
    ..These studies will uncover highly fundamental mechanisms of regulation of an important epithelial Na transporter and further our understanding 01 disturbance in acid-base balance, Na retention and hypertension. ..
  49. Preclinical Development of PEG-TNF
    JOHN BOMALASKI; Fiscal Year: 2005
    ..The data from these studies will provide the final information enabling the filing of an IND with the FDA to support human Phase I clinical testing. ..
  50. Neurobiology of Self-Injurious Behavior
    HYDER JINNAH; Fiscal Year: 2005
    ..These studies have direct relevance for understanding the neuroanatomical and neurochemical basis for self-injurious behavior and direct implications for a potential novel treatment strategy. ..
  51. Role of Flip Macrophages
    Richard Pope; Fiscal Year: 2007
    ..These studies will provide insights into mechanisms that contribute to the pathogenesis of RA and potentially the development of new therapeutic strategies. ..
  52. Synergistic Nutraceutical Effects of DLPC and SAMe
    Charles Lieber; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. The role of Mcl-1 in the macrophages and RA
    Richard Pope; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page.................................................................................................................................................. 1 Description, ..
  54. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. [unreadable] [unreadable]..
  55. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
  56. DLPC Treatment of Alcoholic and Non-Alcoholic Fibrosis
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  57. Study of Tritonia crawl circuit and ciliated motor cells
    OWEN WOODWARD; Fiscal Year: 2005
    ..This project may also contribute to the understanding and treatment of motor system disorders as well as demonstrate how the CNS may control non-muscular motor behaviors. ..
  58. Autonomic Function in Insulin Resistance and Diabetes
    Mercedes Carnethon; Fiscal Year: 2005
    ..abstract_text> ..
  59. Proteomic Predictors Of AASK Renal Disease Progression
    Michael Lipkowitz; Fiscal Year: 2005
    ..We also hypothesize that LAD will detect patterns of baseline values in the AASK data set that will predict AASK outcomes; we will re-examine the AASK data set with LAD for this aim. ..
  60. HYPERHOMOCYSTEINEMIA IN PREGNANCY AND PREECLAMPSIA
    James Roberts; Fiscal Year: 2001
    ..These studies could provide insight into what appears to be a unique sensitivity to endothelial dysfunction during pregnancy and whether acute (during pregnancy) insults are as important as life long exposure. ..