hyperoxaluria

Summary

Summary: Excretion of an excessive amount of oxalate in the urine.

Top Publications

  1. ncbi Rapid reversal of hyperoxaluria in a rat model after probiotic administration of Oxalobacter formigenes
    H Sidhu
    Oxalate Division, Ixion Biotechnology, Inc, Alachua, Florida, USA
    J Urol 166:1487-91. 2001
  2. ncbi Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1
    Xiaoxuan Zhang
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Mol Biol 331:643-52. 2003
  3. ncbi Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis
    Saeed R Khan
    Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, USA
    J Urol 168:1173-81. 2002
  4. ncbi Dietary risk factors for hyperoxaluria in calcium oxalate stone formers
    Roswitha Siener
    Department of Urology, and Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Kidney Int 63:1037-43. 2003
  5. ncbi Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria
    Danica Grujic
    Altus Pharmaceuticals, 625 Putnam Avenue, Cambridge, MA 02139, USA
    Am J Nephrol 29:86-93. 2009
  6. ncbi Use of a probiotic to decrease enteric hyperoxaluria
    John C Lieske
    Division of Nephrology and Hypertension, Mayo Clinic, Mayo Hyperoxaluria Center, and Mayo Complementary and Integrative Medicine Program, Rochester, Minnesota 55905, USA
    Kidney Int 68:1244-9. 2005
  7. pmc Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    J Cell Biol 111:2341-51. 1990
  8. ncbi Supplementation of vitamin E and selenium prevents hyperoxaluria in experimental urolithic rats
    Mani Santhosh Kumar
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    J Nutr Biochem 14:306-13. 2003
  9. ncbi Novel mutation in the GRHPR gene in a Chinese patient with primary hyperoxaluria type 2 requiring renal transplantation from a living related donor
    C W Lam
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Am J Kidney Dis 38:1307-10. 2001
  10. pmc Improved methodology to induce hyperoxaluria without treatment using hydroxyproline
    John H Wiessner
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Urol Res 39:373-7. 2011

Detail Information

Publications196 found, 100 shown here

  1. ncbi Rapid reversal of hyperoxaluria in a rat model after probiotic administration of Oxalobacter formigenes
    H Sidhu
    Oxalate Division, Ixion Biotechnology, Inc, Alachua, Florida, USA
    J Urol 166:1487-91. 2001
    ..Male Sprague-Dawley rats were placed on a diet supplemented with ammonium oxalate to induce a state of severe hyperoxaluria. Subgroups of these rats received an esophageal gavage of 1 x 10(3), 10(5), 10(7) or 10(9) O...
  2. ncbi Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1
    Xiaoxuan Zhang
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Mol Biol 331:643-52. 2003
    ..aminotransferase (AGT) is responsible for the potentially lethal hereditary kidney stone disease primary hyperoxaluria type 1 (PH1)...
  3. ncbi Expression of osteopontin in rat kidneys: induction during ethylene glycol induced calcium oxalate nephrolithiasis
    Saeed R Khan
    Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, USA
    J Urol 168:1173-81. 2002
    ..its involvement in vivo in calcium oxalate nephrolithiasis we investigated the renal expression and urinary excretion of osteopontin in normal rats, and rats with hyperoxaluria and calcium oxalate crystal deposits in the kidneys.
  4. ncbi Dietary risk factors for hyperoxaluria in calcium oxalate stone formers
    Roswitha Siener
    Department of Urology, and Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Kidney Int 63:1037-43. 2003
    b>Hyperoxaluria is a major predisposing factor in calcium oxalate urolithiasis...
  5. ncbi Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria
    Danica Grujic
    Altus Pharmaceuticals, 625 Putnam Avenue, Cambridge, MA 02139, USA
    Am J Nephrol 29:86-93. 2009
    b>Hyperoxaluria is a major risk factor for recurrent urolithiasis and nephrocalcinosis...
  6. ncbi Use of a probiotic to decrease enteric hyperoxaluria
    John C Lieske
    Division of Nephrology and Hypertension, Mayo Clinic, Mayo Hyperoxaluria Center, and Mayo Complementary and Integrative Medicine Program, Rochester, Minnesota 55905, USA
    Kidney Int 68:1244-9. 2005
    Patients with inflammatory bowel disease have a 10- to 100-fold increased risk of nephrolithiasis, with enteric hyperoxaluria being the major risk factor for these and other patients with fat malabsorptive states...
  7. pmc Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    J Cell Biol 111:2341-51. 1990
    We have previously shown that in some patients with primary hyperoxaluria type 1 (PH1), disease is associated with mistargeting of the normally peroxisomal enzyme alanine/glyoxylate aminotransferase (AGT) to mitochondria (Danpure, C.J...
  8. ncbi Supplementation of vitamin E and selenium prevents hyperoxaluria in experimental urolithic rats
    Mani Santhosh Kumar
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    J Nutr Biochem 14:306-13. 2003
    ..In order to determine the role of lipid peroxidation related effects for hyperoxaluria, we evaluated the alterations in lipid peroxidation, antioxidants and oxalate synthesizing enzymes in ..
  9. ncbi Novel mutation in the GRHPR gene in a Chinese patient with primary hyperoxaluria type 2 requiring renal transplantation from a living related donor
    C W Lam
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Am J Kidney Dis 38:1307-10. 2001
    We identified a patient with primary hyperoxaluria type 2 (PH2) showing recurrent stone formation, nephrocalcinosis, end-stage renal failure, and rapid oxalate deposition after renal transplantation from a living related donor...
  10. pmc Improved methodology to induce hyperoxaluria without treatment using hydroxyproline
    John H Wiessner
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Urol Res 39:373-7. 2011
    The use of hydroxyproline (HP) to generate hyperoxaluria in the rat is a problem because it is impossible to separate the effect of oxalate on renal injury from the effects of HP and the large array of metabolic intermediates formed when ..
  11. ncbi Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II
    Carla G Monico
    Division of Nephrology, General Clinical Research Center, Mayo Clinic Rochester, Minnesota 55905, USA
    Kidney Int 62:392-400. 2002
    b>Hyperoxaluria may be idiopathic, secondary, or due to primary hyperoxaluria (PH). Hepatic alanine:glyoxylate aminotransferase (AGT) or glyoxylate/hydroxypyruvate reductase (GR/HPR) deficiency causes PHI or PHII, respectively...
  12. ncbi Study of a rat model for calcium oxalate crystal formation without severe renal damage in selected conditions
    Satoshi Yamaguchi
    Department of Medicine, Medical College of Wisconsin and the Department of Veterans Affairs Medical Center, Milwaukee, Wisconsin, USA
    Int J Urol 12:290-8. 2005
    ..In the present study we used EG alone or with NH(4)Cl to study hyperoxaluria, crystaluria, and crystal attachment to renal epithelial cells in rats with minimal renal damage.
  13. ncbi Hyperoxaluria: a gut-kidney axis?
    Stef Robijn
    Laboratory of Pathophysiology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Kidney Int 80:1146-58. 2011
    b>Hyperoxaluria leads to urinary calcium oxalate (CaOx) supersaturation, resulting in the formation and retention of CaOx crystals in renal tissue...
  14. ncbi Novel mutations of the AGXT gene causing primary hyperoxaluria type 1
    Yuet Ping Yuen
    Department of Pathology, Princess Margaret Hospital, Hong Kong, China
    J Nephrol 17:436-40. 2004
    Primary hyperoxaluria type 1 (PH1), an inherited cause of nephrolithiasis, is due to a functional defect of the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT)...
  15. ncbi Hypercalciuria, hyperoxaluria, and hypocitraturia screening from random urine samples in patients with calcium lithiasis
    Miguel Angel Arrabal-Polo
    Urology Department, San Cecilio University Hospital, Granada, Spain
    Urol Res 40:511-5. 2012
    ..with a high percentage of patients with metabolic disorders, such as hypercalciuria, hypocitraturia, and hyperoxaluria. The present study included 50 patients with recurrent calcium lithiasis...
  16. ncbi Enteric hyperoxaluria, recurrent urolithiasis, and systemic oxalosis in patients with Crohn's disease
    Renate Hueppelshaeuser
    Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, University Hospital Cologne, Kerpenerstrasse 62, 50924, Cologne, Germany
    Pediatr Nephrol 27:1103-9. 2012
    ..We aimed to find proof that secondary hyperoxaluria is the main risk factor for the devastating course and correlates with intestinal oxalate absorption.
  17. ncbi Antiurolithic effect of Bergenia ligulata rhizome: an explanation of the underlying mechanisms
    Samra Bashir
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 122:106-16. 2009
    ..Bergenia ligulata is widely used plant in South Asia, mainly India and Pakistan, as a traditional medicine for treatment of urolithiasis...
  18. ncbi Phytotherapy in a rat model of hyperoxaluria: the antioxidant effects of quercetin involve serum paraoxonase 1 activation
    Emilia Amengual-Cladera
    Energy Metabolism and Nutrition Research Group, Department of Fundamental Biology and Health Sciences, University Institute of Health Sciences Research, University of Balearic Islands, Cra Valldemossa Km 7 5, ES 07122 Palma de Mallorca
    Exp Biol Med (Maywood) 236:1133-8. 2011
    ....
  19. ncbi Renal tubular injury induced by hyperoxaluria: evaluation of apoptotic changes
    K Sarica
    Department of Urology, Sahinbey Hospital, University of Gaziantep, Medical School, Gaziantep, Turkey
    Urol Res 29:34-7. 2001
    In order to evaluate the injurious effect of hyperoxaluria on renal tubular epithelium, as judged by apoptotic changes in the renal parenchyma, we performed an experimental study in 20 rabbits...
  20. ncbi Oxalate degrading bacteria: new treatment option for patients with primary and secondary hyperoxaluria?
    Bernd Hoppe
    University Children s Hospital Cologne, Division of Pediatric Nephrology, University of Cologne, Kerpenerstrasse 62, 50931 Cologne, Germany
    Urol Res 33:372-5. 2005
    Current treatment options in patients with primary and secondary hyperoxaluria are limited and do not always lead to sufficient reduction in urinary oxalate excretion...
  21. ncbi Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline
    S R Khan
    Department of Pathology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610 0275, USA
    Kidney Int 70:914-23. 2006
    ..Ethylene glycol (EG)-induced hyperoxaluria in rats is most common, but is criticized because EG and some of its metabolites are nephrotoxic and EG causes ..
  22. ncbi Mitochondrial dysfunction in an animal model of hyperoxaluria: a prophylactic approach with fucoidan
    Coothan Kandaswamy Veena
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    Eur J Pharmacol 579:330-6. 2008
    ..strain were divided into four groups and treated as follows: Group I: vehicle treated control, Group II: hyperoxaluria was induced with 0.75% ethylene glycol in drinking water for 28 days, Group III: fucoidan from F...
  23. ncbi Effect of angiotensin II receptor blockage on osteopontin expression and calcium oxalate crystal deposition in rat kidneys
    Tohru Umekawa
    Department of Urology, Kinki University School of Medicine, Osaka, Japan
    J Am Soc Nephrol 15:635-44. 2004
    b>Hyperoxaluria leads to calcium oxalate (CaOx) crystallization and development of tubulointerstitial lesions in the kidneys...
  24. pmc Effect of NADPH oxidase inhibition on the expression of kidney injury molecule and calcium oxalate crystal deposition in hydroxy-L-proline-induced hyperoxaluria in the male Sprague-Dawley rats
    Jian Zuo
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA
    Nephrol Dial Transplant 26:1785-96. 2011
    ..We have proposed that oxalate (Ox)- and CaOx crystal-induced injury is most likely caused by reactive oxygen species (ROS) produced by activation of membrane nicotinamide adenine dinucleotide phosphate (NADPH) oxidase...
  25. ncbi A serine-to-phenylalanine substitution leads to loss of alanine:glyoxylate aminotransferase catalytic activity and immunoreactivity in a patient with primary hyperoxaluria type 1
    Y Minatogawa
    Department of Biochemistry, Wakayama Medical College, Japan
    Hum Mol Genet 1:643-4. 1992
  26. ncbi Primary hyperoxaluria type I due to a point mutation of T to C in the coding region of the serine:pyruvate aminotransferase gene
    K Nishiyama
    Department of Biochemistry, Hamamatsu University School of Medicine, Shizuoka, Japan
    Biochem Biophys Res Commun 176:1093-9. 1991
    ..alanine:glyoxylate aminotransferase) were obtained from a cDNA library constructed from the liver of a primary hyperoxaluria type I (PH1) case in which the SPT activity was approximately one-hundredth that in control liver...
  27. pmc Pharmacotherapy of urolithiasis: evidence from clinical trials
    Orson W Moe
    University of Texas Southwestern Medical Center, Dallas, Texas 75380, USA
    Kidney Int 79:385-92. 2011
    ....
  28. ncbi Effect of A. lanata leaf extract and Vediuppu chunnam on the urinary risk factors of calcium oxalate urolithiasis during experimental hyperoxaluria
    R Selvam
    Department of Medical Biochemistry, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600 021, India
    Pharmacol Res 43:89-93. 2001
    ..b>Hyperoxaluria was induced in rats using 0.75% ethylene glycol in drinking water. Aerva lanata(3...
  29. ncbi Oxalate stimulates IL-6 production in HK-2 cells, a line of human renal proximal tubular epithelial cells
    Mei Yi Huang
    Signal Transduction and Molecular Urology Laboratory, Division of Urology, Department of Surgery, Denver, Colorado 80262, USA
    Kidney Int 68:497-503. 2005
    ..In the present study, we investigated the role of oxalate, a major constituent of calcium oxalate kidney stone disease, in the production of IL-6 in normal human HK-2 kidney cells...
  30. ncbi Risk factors for developing renal stones in inflammatory bowel disease
    N McConnell
    Biochemistry Department and Gastroenterology Unit, Stobhill Hospital, Glasgow, UK
    BJU Int 89:835-41. 2002
    ..analytes in patients with inflammatory bowel disease, and to investigate the relative importance of hyperoxaluria (associated with fat malabsorption) or reduced stone inhibitors in the development of calculi in these patients...
  31. ncbi Effects of oxalate on the re-initiation of DNA synthesis in LLC-PK1 cells do not involve p42/44 MAP kinase activation
    Sweaty Koul
    Biochemistry and Molecular Biology Laboratory, Vattikuti Urology Institute, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    Kidney Int 61:525-33. 2002
    ....
  32. ncbi Phenotypic expression of primary hyperoxaluria: comparative features of types I and II
    D S Milliner
    Division of Nephrology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 59:31-6. 2001
    ..Marked hyperoxaluria results in urolithiasis, renal failure, and systemic oxalosis...
  33. ncbi Absorptive hyperoxaluria leads to an increased risk for urolithiasis or nephrocalcinosis in cystic fibrosis
    Bernd Hoppe
    University Children s Hospital Cologne, Germany, USA
    Am J Kidney Dis 46:440-5. 2005
    b>Hyperoxaluria has been incriminated to account for the increased incidence of urolithiasis or nephrocalcinosis in patients with cystic fibrosis (CF)...
  34. ncbi Primary hyperoxaluria type 1: strategy for organ transplantation
    Pierre Cochat
    Centre de Référence des Maladies Rénales Rares, Hospices Civils de Lyon, France
    Curr Opin Organ Transplant 15:590-3. 2010
    Primary hyperoxaluria type 1, the most common form of primary hyperoxaluria, is an autosomal recessive disorder caused by a deficiency of the liver-specific enzyme alanine:glyoxylate aminotransferase...
  35. pmc Transplantation outcomes in primary hyperoxaluria
    E J Bergstralh
    Division of Biomedical Statistics and Informatics, Departments of Pediatrics and Internal Medicine, Mayo Clinic Hyperoxaluria Center, 200 First Street SW, Rochester, MN 55905, USA
    Am J Transplant 10:2493-501. 2010
    Optimal transplantation strategies are uncertain in primary hyperoxaluria (PH) due to potential for recurrent oxalosis...
  36. ncbi Acute oxalate nephropathy causing late renal transplant dysfunction due to enteric hyperoxaluria
    A C Rankin
    Renal Department, King s College London School of Medicine, London, UK
    Am J Transplant 8:1755-8. 2008
    ..The patient presented with diarrhea and deteriorating graft function, and a diagnosis of enteric hyperoxaluria secondary to pancreatic insufficiency was made...
  37. ncbi Long term results of liver-kidney transplantation in children with primary hyperoxaluria
    M F Gagnadoux
    Department of Pediatric Nephrology, , , 75743 Paris Cedex 15, France
    Pediatr Nephrol 16:946-50. 2001
    ..transplants in eight children, aged 1-16 years, with end-stage renal failure (ESRF) due to primary hyperoxaluria (PH1)...
  38. ncbi Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats
    Samra Bashir
    Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi 74800, Pakistan
    Phytother Res 24:1250-5. 2010
    ..These data, indicating the presence of antiurolithic activity in Berberis vulgaris root bark, rationalize its medicinal use for the treatment of urolithiasis...
  39. ncbi Diagnostic and therapeutic approaches in patients with secondary hyperoxaluria
    Bernd Hoppe
    University Children s Hospital, Pediatric Nephrology, D 50924 Cologne, Germany
    Front Biosci 8:e437-43. 2003
    Secondary hyperoxaluria is due either to increased intestinal oxalate absorption or to excessive dietary oxalate intake...
  40. ncbi Hyperoxaluria-induced oxidative stress and antioxidants for renal protection
    Saeed R Khan
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida 32610, USA
    Urol Res 33:349-57. 2005
    ....
  41. ncbi Effects of pomegranate juice on hyperoxaluria-induced oxidative stress in the rat kidneys
    Yusuf Ozlem Ilbey
    Department of Urology, Bezm i Alem Valide Sultan Vakif Gureba Research and Education Hospital, Istanbul, Turkey
    Ren Fail 31:522-31. 2009
    ..synthase (iNOS), selective nuclear factor-kB (NF-kB), and p38-mitogene-activated protein kinase (p38-MAPK) on hyperoxaluria-induced oxidative stress and stone formation in rat kidneys...
  42. ncbi The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II
    S D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 8:2063-9. 1999
    Primary hyperoxaluria type II (PH2) is a rare monogenic disorder that is characterized by a lack of the enzyme that catalyzes the reduction of hydroxypyruvate to D-glycerate, the reduction of glyoxylate to glycolate and the oxidation of ..
  43. ncbi Is enalapril adequate for the prevention of renal tissue damage caused by unilateral ureteral obstruction and/or hyperoxaluria?
    T Turan
    Pediatric Urology, Erasmus Medical Center Rotterdam, The Netherlands
    Urol Res 31:212-7. 2003
    Unilateral ureteral obstruction (UUO) and hyperoxaluria (HOX) can lead to end-stage renal disease with tubulointerstitial fibrosis. We investigated the effects of enalapril (E), an ACE-inhibitor, on rat kidneys with either UUO or HOX...
  44. ncbi Physico-chemical alterations of urine in experimental hyperoxaluria: a biochemical approach with fucoidan
    Coothan Kandaswamy Veena
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    J Pharm Pharmacol 59:419-27. 2007
    ..Two groups of male albino Wistar rats (120+/-20 g) received 0.75% ethylene glycol (EG) for 28 days to induce hyperoxaluria, and one of them received sulfated polysaccharides (fucoidan from Fucus vesiculosus, 5 mg kg(-1), s.c...
  45. pmc Selected AGXT gene mutations analysis provides a genetic diagnosis in 28% of Tunisian patients with primary hyperoxaluria
    Ibtihel Benhaj Mbarek
    Biochemistry Department, Sahloul University Hospital, Sousse, Tunisia
    BMC Nephrol 12:25. 2011
    Primary hyperoxaluria type I (PH1) is a rare genetic disorder characterized by allelic and clinical heterogeneity...
  46. ncbi Enteric hyperoxaluria, nephrolithiasis, and oxalate nephropathy: potentially serious and unappreciated complications of Roux-en-Y gastric bypass
    Wayne K Nelson
    Mayo Medical School, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Surg Obes Relat Dis 1:481-5. 2005
    Neither the presence nor prevalence of enteric hyperoxaluria has been recognized after Roux-en-Y gastric bypass (RYGBP)...
  47. ncbi Vitamin E therapy prevents hyperoxaluria-induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status
    Sivagnanam Thamilselvan
    Department of Urology, Ste 2D 34, Henry Ford Health System, One Ford Place, Detroit, MI 48202, USA
    BJU Int 96:117-26. 2005
    To determine whether vitamin E prevents hyperoxaluria-induced stone formation, using a new animal model of calcium oxalate stone disease, as our previous in- vitro and in-vivo studies showed that oxalate and hyperoxaluria induce free-..
  48. ncbi Hyperoxaluria in kidney stone formers treated with modern bariatric surgery
    John R Asplin
    Litholink Corporation and the Section of Nephrology, University of Chicago, Chicago, Illinois, USA
    J Urol 177:565-9. 2007
    Nephrolithiasis and renal failure secondary to severe hyperoxaluria were complications of jejunoileal bypass for obesity, leading to the discontinuation of this procedure in the United States in 1980...
  49. ncbi Effects of angiotensin II subtype 1 receptor blockade by losartan on tubulointerstitial lesions caused by hyperoxaluria
    Jorge Eduardo Toblli
    Laboratory of Experimental Medicine, Hospital Alemán and Instituto de Investigaciones Cardiológicas, Buenos Aires, Argentina
    J Urol 168:1550-5. 2002
    b>Hyperoxaluria is a recognized cause of tubulointerstitial lesions and this circumstance could contribute to cause chronic renal disease...
  50. pmc Enteric oxalate elimination is induced and oxalate is normalized in a mouse model of primary hyperoxaluria following intestinal colonization with Oxalobacter
    Marguerite Hatch
    Dept of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, USA
    Am J Physiol Gastrointest Liver Physiol 300:G461-9. 2011
    ..Kidney Int 69: 691-698, 2006). The main goal of the present study, using a mouse model of primary hyperoxaluria type 1 (PH1), was to test the hypothesis that colonization of the mouse gut by Oxalobacter formigenes could ..
  51. ncbi Hyperoxaluric nephrolithiasis is a complication of Roux-en-Y gastric bypass surgery
    M K Sinha
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 72:100-7. 2007
    ..b>Hyperoxaluria was a prevalent factor even in patients without a prior history of nephrolithiasis, and usually presented more ..
  52. ncbi Sensitivity to meat protein intake and hyperoxaluria in idiopathic calcium stone formers
    Q V Nguyen
    Policlinic of Medicine, University Hospital, Berne, Switzerland
    Kidney Int 59:2273-81. 2001
    ..a meat protein load in male recurrent idiopathic calcium stone formers (ICSFs) with and without mild metabolic hyperoxaluria (MMH and non-MMH, respectively), as well as in healthy controls, and (2) to seek for possible disturbed ..
  53. pmc Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation
    P E Purdue
    Biochemical Genetics Research Group, Clinical Research Centre, Harrow, Middlesex, United Kingdom
    Proc Natl Acad Sci U S A 88:10900-4. 1991
    In approximately one-third of primary hyperoxaluria type 1 patients, disease is associated with a unique protein sorting defect in which hepatic L-alanine:glyoxylate aminotransferase (AGT; EC 2.6.1...
  54. ncbi Enalapril prevents tubulointerstitial lesions by hyperoxaluria
    J E Toblli
    Laboratory of Experimental Medicine, Hospial Alemán, Buenos Aires, Argentina
    Hypertension 33:225-31. 1999
    b>Hyperoxaluria is a recognized cause of tubulointerstitial lesions, and this could contribute to development of hypertension and chronic renal failure...
  55. ncbi Hyperoxaluria after ethylene glycol poisoning
    Ludwig Stapenhorst
    Department of Pediatrics, University Children s Hospital, 50924, Cologne, Germany
    Pediatr Nephrol 23:2277-9. 2008
    ..Metabolic acidosis, hypocalcaemia, and neurological symptoms had not occurred. Four weeks after discharge, both plasma and urinary oxalate levels were normal...
  56. ncbi Ethylene glycol induces hyperoxaluria without metabolic acidosis in rats
    Mike L Green
    Dept of Pathology, Immunology, and Laboratory Medicine, Univ of Florida, College of Medicine, PO Box 100275, Gainesville, FL 32610 00275, USA
    Am J Physiol Renal Physiol 289:F536-43. 2005
    Ethylene glycol (EG) consumption is commonly employed as an experimental regimen to induce hyperoxaluria in animal models of calcium oxalate nephrolithiasis...
  57. ncbi Hyperoxaluria and systemic oxalosis: current therapy and future directions
    Amy E Bobrowski
    Feinberg School of Medicine, Northwestern University, Division of Kidney Diseases, Department of Pediatrics, Children s Memorial Hospital, 2300 Children s Plaza 37, Chicago, IL 60614, USA
    Expert Opin Pharmacother 7:1887-96. 2006
    Excessive urinary oxalate excretion, termed hyperoxaluria, may arise from inherited or acquired diseases...
  58. ncbi Enteric hyperoxaluria: a hidden cause of early renal graft failure in two successive transplants: spontaneous late graft recovery
    Charles Cuvelier
    Department of Nephrology, Cliniques Universitaires St Luc, Brussels, Belgium
    Am J Kidney Dis 40:E3. 2002
    ..identification of steatorrhea with radiologic signs of chronic pancreatitis led to the hypothesis of enteric hyperoxaluria. Surprisingly, 11 months after the second transplantation, graft function improved progressively allowing ..
  59. ncbi A randomized, controlled trial of lactic acid bacteria for idiopathic hyperoxaluria
    David S Goldfarb
    Nephrology Section, New York Harbor VA Medical Center and New York University School of Medicine, New York, NY 10010, USA
    Clin J Am Soc Nephrol 2:745-9. 2007
    ..Some lactic acid bacteria can degrade oxalate in vitro. This study sought to reduce urinary oxalate excretion in calcium stone formers with idiopathic hyperoxaluria.
  60. ncbi Hyperoxaluria: an underestimated cause of rapidly progressive renal failure
    M Tintillier
    Department of Internal Medicine, University Hospital of Mont-Godinne, , Belgium
    Acta Clin Belg 56:360-3. 2001
    b>Hyperoxaluria is rarely considered as a cause of rapidly progressive renal failure. A case is reported of a patient in whom rapidly renal failure developed after subtotal small bowel resection...
  61. ncbi Oral L-arginine supplementation ameliorates urinary risk factors and kinetic modulation of Tamm-Horsfall glycoprotein in experimental hyperoxaluric rats
    Viswanathan Pragasam
    Department of Medical Biochemistry, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    Clin Chim Acta 360:141-50. 2005
    ..We determined whether l-arg supplementation safeguards the renal epithelial cell damage induced by hyperoxaluria with excretion of urinary marker enzymes and lithogenic salts with special reference to Tamm-Horsfall ..
  62. pmc Use of sevelamer hydrochloride as an oxalate binder
    John C Lieske
    Mayo Clinic Division of Nephrology and Hypertension and Mayo Hyperoxaluria Center, Rochester, Minnesota 55905, USA
    J Urol 179:1407-10. 2008
    We tested the hypothesis that the cationic phosphate binder sevelamer hydrochloride could reduce hyperoxaluria and calcium oxalate supersaturation in patients with enteric hyperoxaluria by binding fatty acids, binding phosphate and ..
  63. ncbi Effect of hyperoxaluria on the inhibitory activity of a 45-kD urinary protein
    Ramasamy Selvam
    Department of Medical Biochemistry, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India
    Nephron 90:206-10. 2002
    ..This study was aimed to determine whether hyperoxaluria modifies the kinetic properties of urinary inhibitory proteins...
  64. ncbi Effect of sulphated polysaccharides on erythrocyte changes due to oxidative and nitrosative stress in experimental hyperoxaluria
    C K Veena
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    Hum Exp Toxicol 26:923-32. 2007
    ..b>Hyperoxaluria was induced in two groups by the administration of 0...
  65. ncbi Chronic L-arginine administration increases oxidative and nitrosative stress in rat hyperoxaluric kidneys and excessive crystal deposition
    Ho Shiang Huang
    Department of Urology, National Taiwan University Hospital, Taiwan
    Am J Physiol Renal Physiol 295:F388-96. 2008
    ..group (received L-arginine + l-NAME), HP group [received hydroxyl-L-proline (HP, 5%) mixed with chow to induce hyperoxaluria], L + HP group (received HP + L-arginine), HP + LN group, and L + HP + LN group...
  66. ncbi Attenuation of oxalate-induced nephrotoxicity by eicosapentaenoate-lipoate (EPA-LA) derivative in experimental rat model
    M Lenin
    Department of Medical Biochemistry, University of Madras, India
    Prostaglandins Leukot Essent Fatty Acids 65:265-70. 2001
    b>Hyperoxaluria is one of the major risk factors for the formation of urinary calcium oxalate stones. Calcium oxalate crystals and their deposition have been implicated in inducing renal tubular damage...
  67. ncbi Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric rats
    Lakshminarasimhan Vidya
    Department of Medical Biochemistry, Dr A L M Post Graduate Institute of Basic Medical Sciences, Taramani, Chennai 600 113, India
    Phytother Res 16:514-8. 2002
    ..Treatment with lupeol and lupeol linoleate reduced the extent of tubular damage as evidenced from reduced enzymuria and minimized the excretion of stone forming constituents...
  68. ncbi The preventive effect of sodium pentosan polysulfate against renal stone formation in hyperoxaluric rats
    Tatsuya Nakatani
    Department of Urology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Urol Res 30:329-35. 2002
    Sodium pentosan polysulfate (SPP), a semi-synthetic glycosaminoglycan, was administered to rats with hyperoxaluria, induced by a vitamin B6 deficient diet, as a model of calcium oxalate stone formation...
  69. ncbi Ascorbate increases human oxaluria and kidney stone risk
    Linda K Massey
    Department of Food Science and Human Nutrition, Washington State University, Spokane, WA, USA
    J Nutr 135:1673-7. 2005
    ..391 +/- 71 micromol/d N). The 1000 mg AA twice each day increased urinary oxalate and TRI for calcium oxalate kidney stones in 40% of participants, both stoneformers and non-stoneformers...
  70. ncbi Effects of an oxalate load on urinary oxalate excretion in calcium stone formers
    Claudia de O G Mendonça
    Nephrology Division, Universidade Federal de Sao Paulo, Brazil
    J Ren Nutr 13:39-46. 2003
    ..To investigate the oxalate intake and the effect of an oxalate load on urinary oxalate excretion in calcium stone-forming (CSF) patients...
  71. ncbi Roux-en-Y gastric bypass is associated with early increased risk factors for development of calcium oxalate nephrolithiasis
    Branden G Duffey
    Department of Urologic Surgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Am Coll Surg 206:1145-53. 2008
    Patients treated for obesity with jejunoileal bypass (JIB) experienced a marked increased risk of hyperoxaluria, nephrolithiasis, and oxalate nephropathy developing...
  72. ncbi Lipid peroxidation is not the underlying cause of renal injury in hyperoxaluric rats
    Mike L Green
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 00275, USA
    Kidney Int 68:2629-38. 2005
    b>Hyperoxaluria is a major risk factor of calcium oxalate stone disease and renal injury is thought to be a significant initiating event...
  73. ncbi Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration
    C Campieri
    Department of Nephrology, S. Orsola University Hospital, Bologna, Italy
    Kidney Int 60:1097-105. 2001
    BACKGROUND: Hyperoxaluria is a major risk factor for renal stones, and in most cases, it appears to be sustained by increased dietary load or increased intestinal absorption...
  74. ncbi Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, Veterans Affairs Medical Center in Manhattan, 423 E23 St, Rm 18064S, New York, NY 10010, USA
    Am J Physiol Renal Physiol 293:F1935-43. 2007
    ..In contrast, experimentally induced hyperoxaluria provokes widespread intratubular calcium oxalate crystallization and stone formation in OPN/THP-double null ..
  75. ncbi Pathophysiological correlates of two unique renal tubule lesions in rats with intestinal resection
    Elaine Worcester
    Nephrology Section MC 5100, Univ of Chicago, 5841 South Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Renal Physiol 291:F1061-9. 2006
    ..001). Rats with bowel resection fed normal chow had mild hyperoxaluria but high urine CaOx supersaturation; four of these rats developed birefringent crystal deposition with tubule ..
  76. ncbi Renal prothrombin mRNA is significantly decreased in a hyperoxaluric rat model of nephrolithiasis
    P K Grover
    Urology Unit, Department of Surgery, Flinders Medical Centre and Flinders University Bedford Park 5042, South Australia, Australia
    J Pathol 210:273-81. 2006
    ..This is the first report of a significant reduction in the renal expression of a urinary protein well documented to inhibit CaOx crystal growth and aggregation in undiluted human urine in vitro...
  77. ncbi Expression of inter-alpha inhibitor related proteins in kidneys and urine of hyperoxaluric rats
    M T Moriyama
    Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    J Urol 165:1687-92. 2001
    ..MATERIALS AND METHODS: Hyperoxaluria was induced in male Sprague-Dawley rats by administering 0.75% ethylene glycol...
  78. ncbi Essential roles of CFEX-mediated Cl(-)-oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis
    P S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Kidney Int 70:1207-13. 2006
    ..CFEX-null mice were found to have hyperoxaluria and a high incidence of calcium oxalate urolithiasis...
  79. ncbi Effect of grapefruit juice on urinary lithogenicity
    D S Goldfarb
    Kidney Stone Prevention and Treatment Programs, New York Veterans Affairs Medical Center, New York, New York, USA
    J Urol 166:263-7. 2001
    ..No changes in lithogenicity were demonstrated. The results do not demonstrate an effect of grapefruit juice for increasing lithogenicity. The basis of the observations of epidemiological studies remain unexplained...
  80. ncbi Renal peroxidative changes mediated by oxalate: the protective role of fucoidan
    Coothan Kandaswamy Veena
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India
    Life Sci 79:1789-95. 2006
    ..Damaged epithelia might act as nidi for stone formation aggravating calcium oxalate precipitation during hyperoxaluria. In the present study, the beneficial effects of fucoidan on oxalate-induced free radical injury were ..
  81. ncbi [Metaphylaxis of recurrent renal calcium stones]
    A Pasch
    Klinik und Poliklinik für Nephrologie und Hypertonie, Universitatsspital, Bern
    Ther Umsch 64:253-8. 2007
    ..This review article describes and discusses the currently established treatment options for the prophylaxis of calcium-containing renal stones...
  82. ncbi Mild tubular damage induces calcium oxalate crystalluria in a model of subtle hyperoxaluria: Evidence that a second hit is necessary for renal lithogenesis
    Giovanni Gambaro
    Department of Biomedical and Surgical Sciences, Division of Nephrology, University of Verona, Verona, Italy
    J Am Soc Nephrol 17:2213-9. 2006
    ..The hypothesis that TE damage (known to enhance crystal attachment) is lithogenic in mild hyperoxaluria was tested. Mild hyperoxaluria was induced in male Wistar rats using ethylene glycol (EG; 0...
  83. ncbi High incidence of hyperoxaluria in generalized peroxisomal disorders
    Christiaan S van Woerden
    Department of Pediatrics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Genet Metab 88:346-50. 2006
    ..Its deficiency causes primary hyperoxaluria type 1 (PH1, MIM 259900), an inborn error of glyoxylate metabolism characterized by hyperoxaluria, ..
  84. ncbi Counteraction of oxalate induced nitrosative stress by supplementation of l-arginine, a potent antilithic agent
    Viswanathan Pragasam
    Department of Medical Biochemistry, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    Clin Chim Acta 354:159-66. 2005
    ..We investigated the role of l-arg in ethylene glycol (EG)-induced urolithic rat model and observed its antilithic and antioxidative properties...
  85. ncbi Where can I find information on the oxalate content of foods?
    Wendy Marcason
    ADA s Knowledge Center Team in Chicago, IL, USA
    J Am Diet Assoc 106:627-8. 2006
  86. ncbi Changes in renal hemodynamics and urodynamics in rats with chronic hyperoxaluria and after acute oxalate infusion: role of free radicals
    Ho Shiang Huang
    Department of Urology, National Taiwan University Hospital, Taipei, Taiwan
    Neurourol Urodyn 22:176-82. 2003
    ..study was to evaluate possible changes in renal hemodynamic and urodynamic parameters in rats with chronic hyperoxaluria and after acute oxalate challenge...
  87. ncbi Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria
    Agnes Kaelin
    Department of Nephrology, University Hospital, P O Box 69, 06002, Nice Cedex 1, France
    Urol Res 32:61-8. 2004
    ..This clinical study was performed in a population of male ICSF with (Hyperoxalurics, n=55) or without hyperoxaluria (Normooxalurics, n=57) as well as in 100 healthy male control subjects...
  88. ncbi Salubrious effect of C-phycocyanin against oxalate-mediated renal cell injury
    Shukkur Muhammed Farooq
    Department of Medical Biochemistry, Dr AL Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India
    Clin Chim Acta 348:199-205. 2004
    ....
  89. ncbi [Clinical value of crystalluria study]
    M Daudon
    Laboratoire de Biochimie A, Groupe Hospitalier Necker Enfants Malades, Paris
    Ann Biol Clin (Paris) 62:379-93. 2004
    ..3 mmol/L); a crystal number > 200/mm 3 is highly suggestive of heavy hyperoxaluria of genetic or absorptive origin...
  90. ncbi Effect of verapamil on urinary stone-forming risk factors
    Kemal Sarica
    Department of Urology, Memorial Hospital, Istanbul, Turkey
    Urol Res 35:23-7. 2007
    ....
  91. ncbi Oxalate absorption and endogenous oxalate synthesis from ascorbate in calcium oxalate stone formers and non-stone formers
    Weiwen Chai
    Department of Family and Consumer Sciences Nutrition, University of Wyoming, Laramie, WY 82071, USA
    Am J Kidney Dis 44:1060-9. 2004
    Increased rates of either oxalate absorption or endogenous oxalate synthesis can contribute to hyperoxaluria, a primary risk factor for the formation of calcium oxalate-containing kidney stones...
  92. ncbi Prophylactic role of phycocyanin: a study of oxalate mediated renal cell injury
    Shukkur Muhammed Farooq
    Department of Medical Biochemistry, Dr ALM Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600113, India
    Chem Biol Interact 149:1-7. 2004
    ..Male Wistar rats were divided into four groups. Hyperoxaluria was induced in two of these groups by intraperitoneal infusion of sodium oxalate (70 mg/kg) and a pretreatment ..
  93. ncbi Expression of nuclear pore complex oxalate binding protein p62 in experimental hyperoxaluria
    P Sivakamasundari
    Department of Medical Biochemistry, Dr ALM PGIBMS, University of Madras, Chennai, India
    Nephron Exp Nephrol 97:e106-14. 2004
    ..This study was aimed at determining whether hyperoxaluria induces the expression of nuclear pore complex oxalate binding protein p62 which has the transport function...
  94. ncbi Limitation of apoptotic changes in renal tubular cell injury induced by hyperoxaluria
    Kemal Sarica
    Department of Urology, Sahinbey Medical Center, University of Gaziantep, Medical School, 27070 Kolejtepe Gaziantep, Turkey
    Urol Res 32:271-7. 2004
    Renal tubular epithelium is the major target for oxalate induced injury, and sustained hyperoxaluria together with CaOx crystal formation/deposition may induce renal tubular cell damage and/or dysfunction...
  95. ncbi Nephrocalcinosis: molecular insights into calcium precipitation within the kidney
    John A Sayer
    School of Cell and Molecular Biosciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Clin Sci (Lond) 106:549-61. 2004
    ....
  96. ncbi Angiotensin II involvement in adaptive enteric oxalate excretion in rats with chronic renal failure induced by hyperoxaluria
    Marguerite Hatch
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100275, Gainesville, FL 32610, USA
    Urol Res 31:426-32. 2003
    ..examine renal and intestinal handling of oxalate in rats with chronic renal failure (CRF) induced by chronic hyperoxaluria. A rat model for chronic renal failure, induced by chronic hyperoxaluria (CH-CRF), was produced by unilateral ..
  97. ncbi Minipump induced hyperoxaluria and crystal deposition in rats: a model for calcium oxalate urolithiasis
    Susan Ruth Marengo
    Department of Urology, School of Medicine, Case Western Reserve University, Cleveland, Ohop 44106 4931, USA
    J Urol 171:1304-8. 2004
    ..To address this problem we developed a model of hyperoxaluria and calcium oxalate crystal deposition by implanting osmotic minipumps subcutaneously into male rats, that is ..
  98. ncbi [24-hour urinary oxalate excretion in healthy children and in children with calcium urolithiasis]
    Przemysław Sikora
    Klinika Nefrologii Dzieciecej Uniwersytetu Medycznego w Lublinie
    Pol Merkur Lekarski 24:76-9. 2008
    b>Hyperoxaluria is one of the crucial risk factors for calcium stone formation.
  99. ncbi Antiurolithic effect of lupeol and lupeol linoleate in experimental hyperoxaluria
    Varatharajan Sudhahar
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    J Nat Prod 71:1509-12. 2008
    ..of the pentacyclic triterpene lupeol (1) and its ester derivative, lupeol linoleate (2), in experimental hyperoxaluria. Hyperoxaluria was induced in male Wistar rats with 0.75% ethylene glycol (EG) in drinking water for 28 days...
  100. ncbi The urinary response to an oral oxalate load in recurrent calcium stone formers
    Mina S Krishnamurthy
    Department of Surgery Urology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Urol 169:2030-3. 2003
    ..studied the urinary response to an oral oxalate load in male and female idiopathic recurrent calcium oxalate stone formers with and without mild hyperoxaluria to evaluate the potential pathophysiological significance of dietary oxalate.
  101. ncbi Erythropoietin resistance as a result of oxalosis in bone marrow
    G Sahin
    Departments of Nephrology, Osmangazi University Medical School, Eskisehir, Turkey
    Clin Nephrol 63:402-4. 2005
    ..To the best of our knowledge, our patient represents the first case in the literature describing the association between the oxalate deposition and EPO resistance...

Research Grants63

  1. Probiotic-Induced Elimination of Oxalate to treat Hyperoxaluria
    Marguerite Hatch; Fiscal Year: 2013
    ..1) In the genetic disease of Primary Hyperoxaluria Type 1 (PH1), an increased endogenous production of oxalate, due to a deficiency of the liver enzyme alanine-..
  2. The Effect of Gastric Bypass Surgery on Renal Function and Metabolism
    Benjamin K Canales; Fiscal Year: 2013
    ..during weight loss for glycemic and hypertension control, up to 75% of RYGB patients will develop sustained hyperoxaluria post-operatively, and a subset will develop kidney stones, nephrocalcinosis, impaired renal function, or even ..
  3. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    ..They are also seen deposited in the kidneys of patients with primary or enteric hyperoxaluria. These crystals can be nephrotoxic, evoke an inflammatory response leading to fibrosis, loss of nephrons and ..
  4. Identification of a Multi-Analyte Profile for Primary Hyperoxaluria
    James P Mapes; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Primary hyperoxaluria, type 1 (PH1) is a rare, monogenic disorder in which a mutation in the AGXT gene leads to overproduction of oxalate by the liver, resulting in widespread deposition of calcium ..
  5. MR Spectroscopy to Evaluate Liver Repopulation by Transplanted Hepatocytes
    Chandan Guha; Fiscal Year: 2009
    ..in preclinical rodent and murine models of metabolic liver disease, such as Criggler-Najjar syndrome, primary hyperoxaluria and hyperlipidemia...
  6. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2010
    Primary hyperoxaluria type I (PH1) is an autosomal recessive disease caused by excessive oxalate production by hepatocytes due to peroxisomal alanine-glyoxylate aminotransferase (AGT) deficiency, leading to increased conversion of ..
  7. Endogenous Oxalate Synthesis
    Ross P Holmes; Fiscal Year: 2013
    ..Endogenous oxalate synthesis plays an important role in idiopathic calcium oxalate stone disease and primary hyperoxaluria. The pathways that underlie this synthesis are poorly understood despite decades of research...
  8. EPITHELIAL OXALATE AND CITRATE TRANSPORT
    DAVID BRUCE MOUNT; Fiscal Year: 2011
    ..This phenotypic characterization will be correlated with the impact of these polymorphisms on the genetic predisposition to stone disease and hyperoxaluria, as determined in Project 3.
  9. Oxalate handling and Oxalobacter formigenes colonization in a mouse model
    John Knight; Fiscal Year: 2013
    ..In addition, preliminary studies suggest that administering oral doses of OxF to patients with primary hyperoxaluria may decrease oxalate excretion...
  10. Drosophila model of oxalate nephrolithiasis
    Michael F Romero; Fiscal Year: 2013
    ..oxalate excretion are important pathogenic factors producing the CaOx stones that form in patients with hyperoxaluria. Slc26a6 is an electrogenic Cl-/ox2- exchanger involved in both intestinal absorption and renal excretion of ..
  11. Hereditary Causes of Nephrolithaisis and Kidney Failure
    DAWN SCHMAUTZ MILLINER; Fiscal Year: 2013
    ..Patients with primary hyperoxaluria (PH), cystinuria, APRT deficiency (dihydroxyadeninuria, DMA), and Dent disease experience stones beginning in ..
  12. Ninth International Primary Hyperoxaluria Workshop
    Ross P Holmes; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Primary Hyperoxaluria is a rare genetic disease that often results in kidney failure and premature death...
  13. Hydroxproline Catabolism and Hyperoxaluria
    W Todd Lowther; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Primary hyperoxaluria types I and 2 (PH1 and PH2) are characterized by an inability to efficiently metabolize glyoxylate as a consequence of functional defects in alanine-glyoxylate aminotransferase ..
  14. Oxalate Reduction by Oral Administration of Oxalate Degrading Enzymes
    Qingshan Li; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Severe diseases or conditions such as primary hyperoxaluria (PH), secondary hyperoxaluria (SH), and Zellweger spectrum disorders (ZSD) continues to be a healthcare problem...
  15. Reduction of Dietary Oxalate
    Qingshan Li; Fiscal Year: 2013
    ..In fact, roughly 2.4 million Americans (0.75% of the US population) have either enteric or absorptive hyperoxaluria and suffer from recurrent calcium oxalate stone formation...
  16. Roles of SLC26A6 in Renal NaCI Transport and Prevention of Oxalate Urolithiasis
    Peter S Aronson; Fiscal Year: 2013
    ..that the latter process is critical to limiting net intestinal absorption of oxalate and preventing hyperoxaluria and calcium oxalate urolithiasis...
  17. Protein Misprocessing in Krabbe Disease
    Christopher Eckman; Fiscal Year: 2007
    ..degraded, similar to other misfolded protein disorders such as nephrogenic diabetes insipidus, primary hyperoxaluria type 1, congenital nephrotic syndrome, and other lysosomal storage diseases such as Gaucher disease and Fabry ..
  18. CRYSTAL INTERACTIONS IN RENAL STONE DISEASE
    Neil S Mandel; Fiscal Year: 2010
    ..hyperoxaluric conditions that may have limited our ability to see the early events resulting from chronic mild hyperoxaluria as seen in idiopathic CaOx stone patients...
  19. Analysis of PH1-associated alanine:glyoxylate aminotranferase (AGT) using yeast
    Chandra L Tucker; Fiscal Year: 2011
    Primary Hyperoxaluria type I (PH1) is a severe kidney stone disease caused by deficiency of the protein alanine: glyoxylate aminotransferase (AGT)...
  20. REGULATION OF ENTERIC HYPEROXALURI BY OXALOBACTER
    AMMON PECK; Fiscal Year: 2001
    ..of most diets; however, if permitted to accumulate, it can cause numerous pathological conditions, including hyperoxaluria, cardiac conductance disorders, calcium oxalate stones, renal failure, death and possibly inflammatory bowel ..
  21. Hyperoxaluria Leading to Tubule Injury and Kidney Stone Disease
    Neil Mandel; Fiscal Year: 2004
    ..To date, urolithiasis researchers have been limited to cell culure studies or a rat model where hyperoxaluria is induced by either ethylene glycol oral administration that is toxic to multiple organs or by high dose ..
  22. Effect of Pyridoxamine in Oxalate excretion in Stone Disease and Hyperoxaluria
    Jon Scheinman; Fiscal Year: 2007
    ..stone disease, and kidney calcification in the rare but most malignant form of stone disease, primary hyperoxaluria (PH). Pyridoxamine (PM) is a derivative of vitamin B6 that is present in small amounts in normal humans...
  23. Oxalobacter as a therapy in IBD-associated urolithiasis
    AMMON PECK; Fiscal Year: 2006
    ..The absence of this bacterium from the gut has been shown to correlate with hyperoxaluria and an increased frequency of first-time and recurrent calcium oxalate kidney stones; consequently, the ..
  24. Genetic Linkages in Calcium Oxalate Stone Disease
    Neil Mandel; Fiscal Year: 2007
    ..To date, the only well-defined genetic abnormalities leading to hyperoxaluria and calcium oxalate stone disease have been described for primary and secondary hyperoxaluria and associated ..
  25. CALCIUM OXALATE IN BIOLOGICAL SYSTEMS
    ROSS HOLMES; Fiscal Year: 1999
    ..It is anticipated that this Conference will have a significant impact in promoting research in several health related fields including kidney stones and primary hyperoxaluria.
  26. NOVEL ENZYME FORMULATION FOR TREATMENT OF HYPEROXALURIA
    Bhami Shenoy; Fiscal Year: 2001
    ..in dialysis equipment or extracorprealdevices to reduce the oxalate content of blood in patients with Primary Hyperoxaluria. If successful, these approaches will lead to the introduction of novel, efficient enzyme therapy for the ..
  27. ENTERIC ELIMINATION OF OXALIC ACID
    Marguerite Hatch; Fiscal Year: 1999
    ..from food or from metabolic processes and currently there is no pharmacological treatment for reducing hyperoxaluria. The studies proposed here focus on the novel concept of reducing urinary oxalate by innocuously excreting ..
  28. OXALOBACTER FORMIGENES DIAGNOSTIC KIT DEVELOPMENT
    Robert Harris; Fiscal Year: 2003
    Absence of Oxalobacter formigenes (Oxf) from the GI-tract is a risk factor for development of hyperoxaluria and calcium oxalate kidney stones...
  29. Structure and Enzyme Function in Glyoxylate Metabolism and Hyperoxaluria
    W Lowther; Fiscal Year: 2007
    ..Defects in human GRHPR are present in the rare genetic disease primary hyperoxaluria type 2 (PH2)...
  30. Renal Oxalate Secretion
    Robert Freel; Fiscal Year: 2004
    b>Hyperoxaluria is one of the principal risk factors in the etiology of renal stone disease and in hyperoxaluric diseases like Primary Hyperoxaluria the renal excretory pathways are continuously challenged to excrete the oxalate load...
  31. UROLITHIASIS--ROLE OF NEPHRON DYSFUNCTION/INJURY
    Julie Jonassen; Fiscal Year: 2003
    ..Aim 3 will determine whether hyperoxaluria in experimental animals will evoke changes in renal cell function which are comparable to those observed in ..
  32. OXALOBACTER FORMIGENES DIAGNOSTIC KIT DEVELOPMENT
    Harmeet Sidhu; Fiscal Year: 2000
    b>Hyperoxaluria, an imbalance in oxalate homeostasis, is associated with idiopathic kidney stone disease, cystic fibrosis, Crohn's disease, and vestibulitis (vulvodynia)...
  33. TISSUE-CRYSTAL INTERACTION CA OXALATE NEPHROLITHIASIS
    Saeed Khan; Fiscal Year: 2003
    ..It is our hypothesis that calcium oxalate stone formation involves a cascade of events which starts with hyperoxaluria. A moderate hyperoxaluric challenge induces increased production of crystallization modulators such as ..
  34. CaP, crystal responsible for idiopathic nephrolithasis
    Saeed Khan; Fiscal Year: 2008
    ..Type density and size must conform to limits and specifications provided in the PHS 398Instructions. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  35. Enteric Elimination and Degradation of Oxalic Acid
    Marguerite Hatch; Fiscal Year: 2002
    Approximately one million cases of stone disease are diagnosed in the United States every year and hyperoxaluria is considered to be a major risk factor...
  36. CALCIUM OXALATE IN BIOLOGICAL SYSTEMS
    Marguerite Hatch; Fiscal Year: 2002
    ..abstract_text> ..
  37. Oxalate Handling in PAT1 and DRA Knockout Mice
    Marguerite Hatch; Fiscal Year: 2010
    b>Hyperoxaluria is considered a major risk factor in the genesis of calcium oxalate stone disease which occurs in about 12% of the U. S. population costing an estimated $2 billion annually...
  38. Influence of genotype on urinary oxalate excretion
    CARLA MONICO; Fiscal Year: 2007
    ..Although PH is rare, idiopathic calcium oxalate nephrolithiasis is extremely common, and mild hyperoxaluria appears to be an important pathogenic factor in many affected patients...
  39. Mechanisms of Oxalobacter-Induced Enteric Oxalate Excretion
    Marguerite Hatch; Fiscal Year: 2010
    b>Hyperoxaluria is considered to be a major risk factor in calcium oxalate stone disease which occurs in about 12% of the American population and, apart from reducing dietary sources of oxalate, there is currently no pharmacological ..
  40. 8th International Primary Hyperoxaluria Workshop
    Marguerite Hatch; Fiscal Year: 2007
    ..by applicant): This is an application requesting funds to partially support the 8th International Primary Hyperoxaluria Workshop being held in London, United Kingdom, on June 29 - 30, 2007...
  41. Role of Nanobacteria in Human Calcifying Disease
    JOHN LIESKE; Fiscal Year: 2004
    ..abstract_text> ..
  42. Oxalate-Induced Renal Scarring and Crystal Retention
    JOHN LIESKE; Fiscal Year: 2003
    Renal manifestations of hyperoxaluria include nephrolithiasis and, when extreme, interstitial scarring and loss of kidney function...
  43. Nephrolithiasis and Chronic Kidney Disease
    JOHN LIESKE; Fiscal Year: 2007
    ..This will gain additional urgency if in fact we demonstrate that NL is a significant risk factor for CKD. [unreadable] [unreadable] [unreadable]..
  44. NOVEL INHIBITOR OF CRYSTAL ADHESION TO RENAL CELLS
    JOHN LIESKE; Fiscal Year: 2004
    ..Achieving these specific aims will provide new knowledge about mechanisms that mediate stone formation, and provide a rational basis for design of novel strategies to treat and/or prevent this disease. ..
  45. Use of symbiotics to reduce urinary oxalate excretion
    JOHN LIESKE; Fiscal Year: 2007
    Renal manifestations of chronic hyperoxaluria include nephrolithiasis and, when extreme, interstitial scarring and progressive loss of function. The clinical outcome can be dismal...
  46. Osteoporosis in Hypercalciuric Kidney Stone Formers
    John Asplin; Fiscal Year: 2003
    ..We hope to use the algorithm developed in this research to expand out services to include bone disease management in kidney stone forming patients and their families. ..
  47. Treatment of Calcium Nephrolithiasis Sodium Thiosulfate
    John Asplin; Fiscal Year: 2006
    ..New, more effective and better tolerated drugs are needed to reduce the recurrence of kidney stones in these patients. [unreadable] [unreadable] [unreadable]..
  48. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  49. DIET SALT, CALCIUM KIDNEY STONES, BONE IN STONE FORMERS
    Linda Massey; Fiscal Year: 2001
    ..Reduction of dietary NaC1 from typical intakes of 200 mmol/day to an intake of 50 mmol/day may decrease the risk of recurrence of calcium-containing kidney stones and slow rates of bone loss, thus reducing risk of osteoporosis as well. ..
  50. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
  52. 11th International Symposium on Urolithiasis
    ROSS HOLMES; Fiscal Year: 2008
    ..Particular emphasis will be placed on using the financial support to assist new, young, female and minority researchers to attend the meeting. [unreadable] [unreadable] [unreadable]..
  53. Oxalate & Crystal Renal Phenotypes: A Microarray Study
    Susan Ruth Marengo; Fiscal Year: 2003
    Despite the fact that hyperoxaluria is an established risk factor for calcium oxalate (CaOx) urolithiasis, except for extreme cases, oxalate's exact role in urolithiasis is not well understood...
  54. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..
  55. MOLECULAR MECHANISMS OF PROXIMAL TUBULE ION TRANSPORT
    PETER ARONSON; Fiscal Year: 2006
    ..nephrolithiasis, osteoporosis) and NaC1 transport (eg. hypertension, congestive heart failure). ..
  56. Prevention of Renal Damage in Primary Hyperoxaluria
    Dawn Milliner; Fiscal Year: 2008
    Primary hyperoxaluria (PH) is a rare autosomal recessive disorder (estimated incidence 1:120,000 births)...
  57. Glyoxylate Reductase and Primary Hyperoxaluria
    Ross P Holmes; Fiscal Year: 2010
    Primary hyperoxaluria is a rare, genetic disorder that results from an excessive endogenous synthesis of oxalate...
  58. Continuous Treatment with Oxalate Changes Renal Physiology and Morphology (DK0750
    Susan Ruth Marengo; Fiscal Year: 2008
    ..The standard 14D protocol models moderate-to-severe hyperoxaluria in that it induces a greater than or equal to 3x increase in oxalate excretion and intratubular CaOx-..
  59. Chronic Kidney Disease with Benign Prostatic Hyperplasia
    ANDREW RULE; Fiscal Year: 2004
    ..Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD. ..
  60. 7th International Workshop on Primary Hyperoxaluria
    Dawn Milliner; Fiscal Year: 2005
    This is the seventh in a series of workshops for scientists and clinicians to share recent work in primary hyperoxaluria (PH) and oxalate-mediated disease to be held October 8-10, 2004 at Mayo Clinic in Rochester, Minnesota...
  61. THE PHYSIOLOGY AND METABOLISM OF VITAMIN D
    Rajiv Kumar; Fiscal Year: 2003
    ..Results of this investigation could lead to a better understanding of the pathogenesis of bone diseases and the formulation of new therapeutic strategies in disorders such as hyperparathyroidism and osteoporosis. ..