hyperbilirubinemia

Summary

Summary: Pathologic process consisting of an abnormal increase in the amount of BILIRUBIN in the circulating BLOOD, which may result in JAUNDICE.

Top Publications

  1. pmc Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
    Serena Sanna
    Istituto di Neurogenetica e Neurofarmacologia del Consiglio Nazionale delle Ricerche, Monserrato, 09042 Cagliari, Italy
    Hum Mol Genet 18:2711-8. 2009
  2. pmc Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice
    Trinity Vera
    Dept of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 297:R738-43. 2009
  3. pmc Hyperbilirubinemia and neurodevelopmental outcome of very low birthweight infants: results from the LIFT cohort
    Gaël Mazeiras
    Department of Neonatal Medicine, St Leon Hospital, Bayonne, France
    PLoS ONE 7:e30900. 2012
  4. ncbi Genetic factors influencing severe atazanavir-associated hyperbilirubinemia in a population with low UDP-glucuronosyltransferase 1A1*28 allele frequency
    Wan Beom Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Clin Infect Dis 51:101-6. 2010
  5. ncbi Understanding severe hyperbilirubinemia and preventing kernicterus: adjuncts in the interpretation of neonatal serum bilirubin
    Michael Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, P O Box 3235, Jerusalem 91031, Israel
    Clin Chim Acta 356:9-21. 2005
  6. ncbi Analysis of the A(TA)(n)TAA configuration in the promoter region of the UGT1 A1 gene in Greek patients with thalassemia intermedia and sickle cell disease
    Vassiliki Kalotychou
    First Department of Medicine, University of Athens School of Medicine, Laikon General Hospital, 11527, Athens, Greece
    Blood Cells Mol Dis 31:38-42. 2003
  7. pmc Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension
    Trinity Vera
    Dept of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1044-9. 2010
  8. pmc Correction of hyperbilirubinemia in gunn rats using clinically relevant low doses of helper-dependent adenoviral vectors
    David Dimmock
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Gene Ther 22:483-8. 2011
  9. ncbi Liver transplantation using grafts of living donors with isolated unconjugated hyperbilirubinemia: a matched case-control study
    Sang Bin Han
    Department of Anesthesiology and Pain Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
    Transpl Int 26:623-30. 2013
  10. ncbi Methylene blue-induced hyperbilirubinemia in neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiency
    T W Gauthier
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Matern Fetal Med 9:252-4. 2000

Detail Information

Publications249 found, 100 shown here

  1. pmc Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
    Serena Sanna
    Istituto di Neurogenetica e Neurofarmacologia del Consiglio Nazionale delle Ricerche, Monserrato, 09042 Cagliari, Italy
    Hum Mol Genet 18:2711-8. 2009
    ..We also show that SLC01B3 variants contribute to idiopathic mild unconjugated hyperbilirubinemia. Thus, SLC01B3 appears to be involved in the regulation of serum bilirubin levels in healthy individuals and ..
  2. pmc Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice
    Trinity Vera
    Dept of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 297:R738-43. 2009
    Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension...
  3. pmc Hyperbilirubinemia and neurodevelopmental outcome of very low birthweight infants: results from the LIFT cohort
    Gaël Mazeiras
    Department of Neonatal Medicine, St Leon Hospital, Bayonne, France
    PLoS ONE 7:e30900. 2012
    ..Bilirubin-related neurotoxicity is an important clinical issue in very low birthweight (VLBW) infants, and the existing literature is inconsistent...
  4. ncbi Genetic factors influencing severe atazanavir-associated hyperbilirubinemia in a population with low UDP-glucuronosyltransferase 1A1*28 allele frequency
    Wan Beom Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    Clin Infect Dis 51:101-6. 2010
    High prevalence of severe atazanavir-associated hyperbilirubinemia in Asians with low prevalence of the UDP-glucuronosyltransferase (UGT)1A1*28 polymorphism suggests the importance of genetic factors other than UGT1A1*28 for atazanavir-..
  5. ncbi Understanding severe hyperbilirubinemia and preventing kernicterus: adjuncts in the interpretation of neonatal serum bilirubin
    Michael Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, P O Box 3235, Jerusalem 91031, Israel
    Clin Chim Acta 356:9-21. 2005
    ..b>Hyperbilirubinemia develops when bilirubin production exceeds the body's capacity to excrete it, primarily by conjugation...
  6. ncbi Analysis of the A(TA)(n)TAA configuration in the promoter region of the UGT1 A1 gene in Greek patients with thalassemia intermedia and sickle cell disease
    Vassiliki Kalotychou
    First Department of Medicine, University of Athens School of Medicine, Laikon General Hospital, 11527, Athens, Greece
    Blood Cells Mol Dis 31:38-42. 2003
    Gilbert's syndrome is characterized by mild unconjugated hyperbilirubinemia. The molecular basis of this syndrome usually concerns an additional dinucleotide insertion (TA) in the A(TA)(n)TAA configuration residing in the promoter region ..
  7. pmc Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertension
    Trinity Vera
    Dept of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1044-9. 2010
    We have previously demonstrated that moderate hyperbilirubinemia decreases blood pressure in ANG II-dependent hypertension through mechanisms that decrease oxidative stress and increase nitric oxide levels...
  8. pmc Correction of hyperbilirubinemia in gunn rats using clinically relevant low doses of helper-dependent adenoviral vectors
    David Dimmock
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Gene Ther 22:483-8. 2011
    ..of uridine diphospho-glucuronosyl transferase 1A1 (UGT1A1) and results in life-threatening unconjugated hyperbilirubinemia. Lifelong correction of hyperbilirubinemia by liver-directed gene therapy using a helper-dependent ..
  9. ncbi Liver transplantation using grafts of living donors with isolated unconjugated hyperbilirubinemia: a matched case-control study
    Sang Bin Han
    Department of Anesthesiology and Pain Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
    Transpl Int 26:623-30. 2013
    ..Elevated unconjugated bilirubin with otherwise normal, so-called isolated unconjugated hyperbilirubinemia (IUHB), is encountered frequently in living liver donor evaluation...
  10. ncbi Methylene blue-induced hyperbilirubinemia in neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiency
    T W Gauthier
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Matern Fetal Med 9:252-4. 2000
    ..Two neonates were subsequently diagnosed with G6PD deficiency. Continued caution is warranted prior to the use of methylene blue in the gravid female...
  11. ncbi An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibility
    S Umit Sarici
    Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine Ihsan Doğramaci Children s Hospital, Ankara, Turkey
    Pediatrics 109:e53. 2002
    ..newborns with ABO incompatibility are at especially greater risk for developing a subsequent significant hyperbilirubinemia because some of these infants also may present with some degree of ABO isoimmune disease...
  12. ncbi Drug-induced hyperbilirubinemia and the clinical influencing factors
    Young Mi Ah
    Department of Pharmacy, Seoul National University Hospital, Seoul, Korea
    Drug Metab Rev 40:511-37. 2008
    b>Hyperbilirubinemia may accompany harmful effects such as jaundice, brain dysfunction, and pharmacokinetic alterations of drugs...
  13. ncbi Genetic factors related to unconjugated hyperbilirubinemia amongst adults
    Ching Shan Huang
    Department of Medical Technology, Fooyin University, Kaohsiung, Taiwan
    Pharmacogenet Genomics 15:43-50. 2005
    ..in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene are involved in the development of unconjugated hyperbilirubinemia. We hypothesize that other genetic factors may also be associated with this disease...
  14. ncbi Clinical implication of the difference between transcutaneous bilirubinometry and total serum bilirubin for the classification of newborns at risk of hyperbilirubinemia
    Karina Rodriguez-Capote
    Pathology and Laboratory Medicine, McMaster University Medical Centre, Hamilton, ON, Canada
    Clin Biochem 42:176-9. 2009
    ....
  15. ncbi Intravenous immunoglobulin G (IVIG) therapy for significant hyperbilirubinemia in ABO hemolytic disease of the newborn
    A M Miqdad
    Department of Pediatrics, Security Forces Hospital, Riyadh, Saudi Arabia
    J Matern Fetal Neonatal Med 16:163-6. 2004
    Although intravenous immunoglobulin G (IVIG) therapy has been reported in hyperbilirubinemia of Rh hemolytic disease, its use in ABO hemolytic disease has been reported in only a few studies...
  16. ncbi Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia
    Scott D Campbell
    Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton Laboratory, Eastern Point Road, MS 8118W 131, Groton, CT 06340, USA
    Chem Biol Interact 150:179-87. 2004
    ..fraction of OATP1B1 inhibited at the clinical exposure level correlated very well with the observed hyperbilirubinemia outcome for these drugs in humans...
  17. pmc Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus
    Ryoichi Fujiwara
    Laboratory of Environmental Toxicology, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:5024-9. 2010
    ..in adults is Gilbert's syndrome, which is characterized by an allelic polymorphism in the UGT1A1 promoter, hyperbilirubinemia was monitored in humanized UGT1 mice that expressed either the Gilbert's UGT1A1*28 allele [Tg(UGT1(A1*28))..
  18. ncbi Hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient male newborns in Al-Ahsa, Saudi Arabia
    Sameer Y Al-Abdi
    Department of Pediatrics, Neonatology Division, MC 315, King Abdulaziz Hospital for National Guard, PO Box 2477, Al Ahsa 31982, Kingdom of Saudi Arabia
    Saudi Med J 31:175-9. 2010
    To study the clinical and laboratory characteristics of hyperbilirubinemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient male newborns from Al-Ahsa area (Ahsais).
  19. ncbi A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes
    Maria Alexandra Brito
    Centro de Patogénese Molecular UBMBE, Faculdade de Farmacia, University of Lisbon, Av das Forcas Armadas, 1600 083 Lisbon, Portugal
    Brain Res 1026:33-43. 2004
    ..bilirubin with synaptosomal membrane vesicles leads to oxidative injury, loss of membrane asymmetry and functionality, and calcium intrusion, thus potentially contributing to the pathogenesis of encephalopathy by hyperbilirubinemia.
  20. ncbi Hyperbilirubinemia among African American, glucose-6-phosphate dehydrogenase-deficient neonates
    Michael Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, PO Box 3525, Jerusalem 91031, Israel
    Pediatrics 114:e213-9. 2004
    Although glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is prevalent in African Americans, their risk of associated neonatal hyperbilirubinemia has not been prospectively studied.
  21. ncbi Hyperbilirubinemia reduces the streptozotocin-induced pancreatic damage through attenuating the oxidative stress in the Gunn rat
    Yan Yan Fu
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Tohoku J Exp Med 222:265-73. 2010
    ..We examined the effect of hyperbilirubinemia on the pancreatic damage caused by streptozotocin (STZ) in the Gunn rat...
  22. ncbi Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: a favorable endogenous response
    Ramesh Kumar
    Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi 110070, India
    Clin Biochem 45:272-4. 2012
    The clinical significance of increased frequency of unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease (NAFLD) is unknown...
  23. ncbi Sorafenib is an inhibitor of UGT1A1 but is metabolized by UGT1A9: implications of genetic variants on pharmacokinetics and hyperbilirubinemia
    Cody J Peer
    Clinical Pharmacology Program, Pharmacology and Experimental Therapeutics Section, Molecular Pharmacology Section, Biostatistics and Data Management Branch, Medical Oncology Branch, and HIV AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Cancer Res 18:2099-107. 2012
    Several case reports suggest sorafenib exposure and sorafenib-induced hyperbilirubinemia may be related to a (TA)(5/6/7) repeat polymorphism in UGT1A1*28 (UGT, uridine glucuronosyl transferase)...
  24. ncbi Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter
    Junko Sugatani
    Department of Pharmaco Biochemistry, Global Center of Excellence for Innovation in Human Health Sciences, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:597-605. 2008
    ..Thus, UGT1A1 gene promoter variations, including the TA repeat polymorphism and T-3279G gtPBREM, have important clinical implications...
  25. ncbi Evidence for higher red blood cell mass in persons with unconjugated hyperbilirubinemia and Gilbert's syndrome
    Yahya Buyukasik
    Department of Hematology, Hacettepe University School of Medicine, Ankara, Turkey
    Am J Med Sci 335:115-9. 2008
    ..The genetic polymorphism responsible from Gilbert's syndrome is not sufficient for the clinical phenotype to occur in many persons. Additional factors are believed to contribute in pathogenesis. Red cell mass may be such a factor...
  26. ncbi Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes
    M Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
    Pediatrics 104:68-74. 1999
    We assessed the incidence of hyperbilirubinemia, defined as serum total bilirubin >/=15 mg/dL (256 micromol/L), in a cohort of Sephardic Jewish female neonates at risk for glucose-6-phosphate dehydrogenase (G-6-PD) deficiency with ..
  27. ncbi The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man
    C C Paulusma
    Department of Gastrointestinal and Liver Diseases, Center for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    J Mol Med 75:420-8. 1997
    ..The human Dubin-Johnson syndrome is an autosomal recessive liver disease characterized by a chronic conjugated hyperbilirubinemia. Patients have impaired hepatobiliary transport of many endogenous and xenobiotic compounds...
  28. ncbi Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome
    Tatsuya Maruhashi
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Circulation 126:598-603. 2012
    Patients with Gilbert syndrome have mild unconjugated hyperbilirubinemia. It has been shown that bilirubin is an endogenous antioxidant...
  29. ncbi Fasting-related hyperbilirubinemia in rats: the effect of decreased intestinal motility
    P Kotal
    First Medical Department, Charles University, Prague, Czech Republic
    Gastroenterology 111:217-23. 1996
    Fasting increases serum bilirubin levels in both humans and rats. Because the pathogenesis of fasting hyperbilirubinemia is not fully understood, the effect of fasting on disposition of bile pigments was investigated in rats.
  30. ncbi Beyond plasma bilirubin: the effects of phototherapy and albumin on brain bilirubin levels in Gunn rats
    Frans J C Cuperus
    Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, Beatrix Children s Hospital University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Hepatol 58:134-40. 2013
    Severe unconjugated hyperbilirubinemia, as occurs in Crigler-Najjar disease and neonatal jaundice, carries the risk of neurotoxicity...
  31. ncbi Plasma fatty acids in premature infants with hyperbilirubinemia: before-and-after nutrition support with fish oil emulsion
    Catherine J Klein
    Childrens National Medical Center, Washington, DC 20010, USA
    Nutr Clin Pract 28:87-94. 2013
    ..76 ± 1.68 kg) transitioning to enteral feeding rather than for resolution of hyperbilirubinemia (direct bilirubin 7.9 ± 4.8 mg/dL)...
  32. ncbi Risk of hyperbilirubinemia in breast-fed infants
    Pi Feng Chang
    Department of Pediatrics, Far Eastern Memorial Hospital, Pan Chiao, Taipei, Taiwan
    J Pediatr 159:561-5. 2011
    To investigate the risk factors for hyperbilirubinemia in infants who are exclusively breast-fed.
  33. ncbi The effects of antipsychotics on behavioral abnormalities of the Gunn rat (unconjugated hyperbilirubinemia rat), a rat model of schizophrenia
    Keiko Tsuchie
    Department of Psychiatry, Faculty of Medicine, Shimane University, Japan
    Asian J Psychiatr 6:119-23. 2013
    There have been reports of a positive relationship between schizophrenia and hyperbilirubinemia. Patients with schizophrenia show a significantly higher frequency of hyperbilirubinemia than patients suffering from other psychiatric ..
  34. ncbi Management of hyperbilirubinemia in newborns: measuring performance by using a benchmarking model
    Shu Chiung Chou
    Center for Quality of Care Research and Education, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Pediatrics 112:1264-73. 2003
    Accreditors hold hospitals accountable for harm from serious newborn hyperbilirubinemia, yet standards for evaluating performance in prevention are lacking.
  35. ncbi A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease
    Hilbert S de Vries
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Crohns Colitis 6:597-602. 2012
    ....
  36. ncbi Moderate hyperbilirubinemia induces a transient alteration of neonatal behavior
    Roberto Paludetto
    Division of Neonatology, Department of Pediatrics Federico II of Naples, Naples, Italy
    Pediatrics 110:e50. 2002
    To investigate the behavioral changes induced by moderate hyperbilirubinemia in the otherwise healthy, untreated newborn infant.
  37. ncbi Unconjugated hyperbilirubinemia is inversely associated with non-alcoholic steatohepatitis (NASH)
    M Hjelkrem
    Brooke Army Medical Center, Gastroenterology Service, Fort Sam Houston, TX, USA
    Aliment Pharmacol Ther 35:1416-23. 2012
    ..We believe that unconjugated hyperbilirubinemia may protect against development of non-alcoholic steatohepatitis (NASH).
  38. ncbi Prognostic value of direct bilirubin in neonatal hyperbilirubinemia
    Manju Mamtani
    Lata Medical Research Foundation, Nagpur, India
    Indian J Pediatr 74:819-22. 2007
    To determine the prognostic value of indirect and direct hyperbilirubinemia in neonates with jaundice.
  39. ncbi Effective treatment of unconjugated hyperbilirubinemia with oral bile salts in Gunn rats
    Frans J C Cuperus
    Pediatric Gastroenterology, Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Gastroenterology 136:673-82.e1. 2009
    We tested the hypothesis that oral administration of bile salts, which are known to increase the biliary excretion of unconjugated bilirubin (UCB), decreases unconjugated hyperbilirubinemia in the Gunn rat model.
  40. ncbi Postoperative hyperbilirubinemia after surgery for gastrointestinal perforation
    Toshirou Nishida
    Department of Surgery, Osaka Police Hospital, Kitayama cho, Tennouji ku, Japan
    Surg Today 32:679-84. 2002
    The aim of this study was to evaluate the risk factors and outcome of patients with hyperbilirubinemia after surgery for generalized peritonitis.
  41. ncbi Modulated function of tissue efflux transporters under hyperbilirubinemia in rats
    Tomoharu Yokooji
    Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5 1 1 Hiro koshingai, Kure, Hiroshima 737 0112, Japan
    Eur J Pharmacol 636:166-72. 2010
    The effect of hyperbilirubinemia on the function of tissue efflux transporters such as multidrug resistance-associated proteins (Mrps) and organic anion transporting polypeptides (Oatps) was examined by measuring tissue accumulation of 2,..
  42. ncbi False-negative results of pre-discharge neonatal bilirubin screening to predict severe hyperbilirubinemia: a need for caution
    Jonathan Slaughter
    Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    Eur J Pediatr 168:1461-6. 2009
    ..using an hour-specific bilirubin nomogram, has been advocated to assess risk for subsequent severe hyperbilirubinemia. However, the false-negative rate has never been adequately studied...
  43. ncbi Parenteral nutrition-associated conjugated hyperbilirubinemia in hospitalized infants
    Catherine J Klein
    Bionutrition Research Program, Children s National Medical Center, and Department of Pediatrics, School of Washington, DC, USA
    J Am Diet Assoc 110:1684-95. 2010
    Parenteral nutrition-associated conjugated hyperbilirubinemia (PNAC), commonly defined as direct bilirubin ≥2 mg/dL (34.2 μmol/L), is primarily a pediatric disease with premature infants being the most susceptible...
  44. ncbi Biliary sludge and hyperbilirubinemia associated with ceftriaxone in an adult: case report and review of the literature
    Courtney L Bickford
    College of Pharmacy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pharmacotherapy 25:1389-95. 2005
    ..Clinicians need to be aware of the association of ceftriaxone and biliary pseudolithiasis and hyperbilirubinemia, and monitor accordingly.
  45. ncbi A new animal model of hemolytic hyperbilirubinemia-induced bilirubin encephalopathy (kernicterus)
    Ann C Rice
    Department of Neurology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Pediatr Res 64:265-9. 2008
    Neonatal hyperbilirubinemia can cause bilirubin encephalopathy (kernicterus)...
  46. ncbi Relationship between unconjugated hyperbilirubinemia and lipoprotein spectrum
    Ivan Očadlík
    2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Neuro Endocrinol Lett 32:360-4. 2011
    ..The presence of LDL1 and LDL2 subpopulations, as well as HDL lipoproteins is considered as protective factor...
  47. ncbi Role of UGT1A1 mutation in fasting hyperbilirubinemia
    T Ishihara
    Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    J Gastroenterol Hepatol 16:678-82. 2001
    BACKGROUND AND AIM: Low-grade fasting hyperbilirubinemia is a common observation in healthy subjects (HS), whereas high-grade fasting hyperbilirubinemia is believed to be a characteristic finding of Gilbert's syndrome...
  48. ncbi [Benign recurrent intrahepatic cholestasis type-II--a rare cause of direct hyperbilirubinemia exacerbations with hepatic fibrosis]
    Meir Mizrahi
    Hadassah Ein Karem Medical Center Jerusalem
    Harefuah 147:381-3, 480. 2008
    Direct hyperbilirubinemia, may result from a variety of pathologies, including structural obstructions with biliary tract occlusions (as in cholelithiasis), infections (e.g...
  49. ncbi UGT1A1 promoter polymorphisms and the development of hyperbilirubinemia and gallbladder disease in children with sickle cell anemia
    Shannon L Carpenter
    Division of Hematology Oncology, Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas 78207, USA
    Am J Hematol 83:800-3. 2008
    ..UGT1A1 genotyping should be considered as a screening tool for predicting children most likely to develop gallbladder disease at a young age...
  50. ncbi Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia: genetic screening is unnecessary
    Richard E Nettles
    J Infect Dis 193:1611-2; author reply 1611-2. 2006
  51. ncbi A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns
    A Kappas
    Rockefeller University Hospital, New York, New York, USA
    Pediatrics 108:25-30. 2001
    ..normal neonates, G-6-PD-deficient neonates experienced a twofold increase in the prevalence of significant hyperbilirubinemia requiring phototherapy...
  52. ncbi Are moderate degrees of hyperbilirubinemia in healthy term neonates really safe for the brain?
    I Soorani-Lunsing
    Department Neurology, University of Groningen, NL 9713 GZ Groningen, The Netherlands
    Pediatr Res 50:701-5. 2001
    In 1994 the American Academy of Pediatrics recommended more liberal rules for the treatment of hyperbilirubinemia in healthy term newborns. Yet, the safety of moderate degrees of hyperbilirubinemia in healthy term newborns is debated...
  53. ncbi Sn-Mesoporphyrin interdiction of severe hyperbilirubinemia in Jehovah's Witness newborns as an alternative to exchange transfusion
    A Kappas
    Rockefeller University, New York, NY 10021, USA
    Pediatrics 108:1374-7. 2001
    ..are Jehovah's Witness adherents lead them to reject the use of exchange transfusions as therapy for severe hyperbilirubinemia in newborns in whom intensive phototherapy has failed to control this problem...
  54. ncbi Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatment
    Tim O Lankisch
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Hepatol 50:1010-8. 2009
    ..Indinavir (IDV) can lead to hyperbilirubinemia in Gilbert's syndrome (UGT1A1*28), which does not explain interindividual severity differences and may thus ..
  55. ncbi Hyperbilirubinemia-related behavioral and neuropathological changes in rats: a possible schizophrenia animal model
    Maiko Hayashida
    Department of Psychiatry, Shimane University Faculty of Medicine, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:581-8. 2009
    Patients with schizophrenia show a significantly higher frequency of hyperbilirubinemia than patients suffering from other psychiatric disorders and the general healthy population...
  56. ncbi A patient with exacerbation of idiopathic pulmonary fibrosis which was resolved probably due to the coexisting hyperbilirubinemia?
    T Ohrui
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 193:245-9. 2001
    ..This case suggests that bile pigments have some important roles in tissue protection against inflammatory damage in IPF, and may illustrate an important key for treatment of this fatal disorder...
  57. ncbi Diagnostic value of hyperbilirubinemia as a predictive factor for appendiceal perforation in acute appendicitis
    Michael Sand
    Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr University, Bochum, Bergstr 26, 44791, Bochum, Germany
    Am J Surg 198:193-8. 2009
    ..This had led to the theory that hyperbilirubinemia in patients with appendicitis may have a predictive potential for the preoperative diagnosis of appendiceal ..
  58. ncbi Prediction of hyperbilirubinemia in near-term and term infants
    D K Stevenson
    Department of Pediatrics, Lucile Salter Packard Children's Hospital, Stanford, California, USA
    Pediatrics 108:31-9. 2001
    ..measurement or in combination with serum total bilirubin (STB) measurements, can predict the development of hyperbilirubinemia during the first 7 days of life...
  59. pmc Mechanism of indinavir-induced hyperbilirubinemia
    S D Zucker
    Division of Digestive Diseases and Division of Infectious Diseases, University of Cincinnati, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 98:12671-6. 2001
    Indinavir is a viral protease inhibitor used for the treatment of HIV infection. Unconjugated hyperbilirubinemia develops in up to 25% of patients receiving indinavir, prompting drug discontinuation and further clinical evaluation in some ..
  60. ncbi Prospective validation of a novel strategy for assessing risk of significant hyperbilirubinemia
    Américo Gonçalves
    Division of General Pediatrics, Pediatrics Department, Hospital Sao Joao, Porto, Portugal
    Pediatrics 127:e126-31. 2011
    Our aim was to validate a strategy for assessing the risk of significant hyperbilirubinemia in newborns with gestational ages of ≥35 weeks by combining predischarge bilirubin percentile data with gestational age data, for a European, ..
  61. ncbi Hyperbilirubinemia and transcutaneous bilirubinometry
    Samar N El-Beshbishi
    Department of Medical Parasitology, Mansoura University, Mansoura, Egypt
    Clin Chem 55:1280-7. 2009
    Neonatal jaundice or hyperbilirubinemia is a common occurrence in newborns...
  62. ncbi Hyperbilirubinemia during atazanavir treatment in 2,404 patients in the Italian atazanavir expanded access program and MASTER Cohorts
    C Torti
    School of Medicine, Institute of Infectious and Tropical Diseases, University of Brescia, P le Spedali Civili, 1, 25123, Brescia, Italy
    Infection 37:244-9. 2009
    Although the mechanism of atazanavir (ATV)-related hyperbilirubinemia is well identified, its prevalence, risk factors, and association with transaminase flares have rarely been assessed in a large population from the "real life" setting.
  63. pmc Hyperbilirubinemia diminishes respiratory drive in a rat pup model
    Oded Mesner
    Division of Neonatology, Ben Gurion University, Beer Sheva, Israel
    Pediatr Res 64:270-4. 2008
    ..the pathophysiologic basis of these episodes and their relationship to other perinatal conditions such as hyperbilirubinemia. Unconjugated hyperbilirubinemia in premature infants, even in moderately high levels, may cause ..
  64. ncbi In vitro analysis of the effect of hyperbilirubinemia on rabbit ureter and bladder
    Nergis Murat
    Department of Pharmacology, Dokuz Eylul University, Inciralti Izmir, Turkey
    Pediatr Nephrol 21:328-32. 2006
    ....
  65. ncbi Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer
    Tatsuharu Yamada
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Langenbecks Arch Surg 390:421-9. 2005
    b>Hyperbilirubinemia is a critical complication following hepatectomy for biliary cancer. Hepatic multidrug resistance protein 2 (MRP2), a bilirubin transporter, is shown to be down-regulated by acute biliary obstruction in rats...
  66. ncbi Hyperbilirubinemia in appendicitis: a new predictor of perforation
    Joaquin J Estrada
    Division of Emergency Non Trauma Surgery, Department of Surgery, Keck School of Medicine of the University of Southern California and Los Angeles County, USC Medical Center, 1200 North State Street, Los Angeles, CA 90033, USA
    J Gastrointest Surg 11:714-8. 2007
    This study examines the relationship between hyperbilirubinemia and appendicitis. It was hypothesized that an association exists between the presence of appendiceal perforation and hyperbilirubinemia...
  67. ncbi The patient presenting with isolated hyperbilirubinemia
    L Fabris
    Department of Surgical and Gastroenterological Sciences, University of Padova, UOC Gastroenterologia, Ospedale Ca Foncello, Treviso, Padova, Italy
    Dig Liver Dis 41:375-81. 2009
    b>Hyperbilirubinemia is a common laboratory finding in clinical practice, being found in several haematological and liver diseases as well as in familial conditions (5-10% in Western countries)...
  68. ncbi Single hepatic venous injection of liver-specific naked plasmid vector expressing human UGT1A1 leads to long-term correction of hyperbilirubinemia and prevention of chronic bilirubin toxicity in Gunn rats
    Zhen Jia
    Department of Pediatrics, Waisman Center, University of Wisconsin Madison, 53705, USA
    Hum Gene Ther 16:985-95. 2005
    ..single injection of pBShUGT1A1 expressing hUGT1A1 under liver-specific regulatory control, for treatment of hyperbilirubinemia in the Gunn rat...
  69. ncbi Urinary tract infection and hyperbilirubinemia
    Hulya Bilgen
    Division of Neonatology, Department of Pediatrics, Marmara University Faculty of Medicine, Istanbul, Turkey
    Turk J Pediatr 48:51-5. 2006
    ..evaluate the incidence of urinary tract infection (UTI) in newborns with asymptomatic, unexplained indirect hyperbilirubinemia in the first two weeks of life...
  70. ncbi Hyperbilirubinemia interferes with ADAMTS-13 activity measurement by FRETS-VWF73 assay: diagnostic relevance in patients suffering from acute thrombotic microangiopathies
    S C Meyer
    J Thromb Haemost 5:866-7. 2007
  71. ncbi Severe hyperbilirubinemia in a 10-year-old girl with a combined disorder of hereditary spherocytosis and Gilbert syndrome
    Kenichi Sugita
    Department of Pediatrics, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Pediatr Int 49:540-2. 2007
  72. ncbi Hepatobiliary disease in neonatal lupus: prevalence and clinical characteristics in cases enrolled in a national registry
    Lela A Lee
    Departments of Dermatology and Medicine, University of Colorado School of Medicine, and Department of Medicine, Denver Health Medical Center, Denver, Colorado, USA
    Pediatrics 109:E11. 2002
    ..To extend the information base on the hepatobiliary manifestations of neonatal lupus erythematosus (NLE) with regard to frequency of occurrence, clinical characteristics, and outcome...
  73. pmc Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism
    C F Xu
    GlaxoSmithKline, Research and Development, Genetics Division, New Frontiers Science Park North, Room H30 2 060, Third Avenue, Harlow, Essex CM19 5AW, UK
    Br J Cancer 102:1371-7. 2010
    ..This study examined polymorphisms in molecules involved in pharmacokinetic and pharmacodynamic pathways of pazopanib and their association with hepatic dysfunction...
  74. ncbi Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia
    Junko Sugatani
    Department of Pharmaco Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biochem Biophys Res Commun 292:492-7. 2002
    ..At least one T-3263G allele was found in 21 of 25 subjects with mild hyperbilirubinemia (Gilbert's syndrome); this frequency (0...
  75. ncbi Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes
    Shojiro Kikuchi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Genet 31:320-5. 2002
    ..This phenotype is similar to human conjugated hyperbilirubinemia in Dubin-Johnson syndrome, which is caused by mutations in the multidrug resistance protein 2 (MRP2, gene ..
  76. ncbi Sickle cell disease, extreme hyperbilirubinemia, and pericardial tamponade: case report and review of the literature
    Imtiaz Khurshid
    Department of Medicine, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
    Crit Care Med 30:2363-7. 2002
    ..We report a patient who presented with intrahepatic cholestasis, a rare and potentially lethal complication of sickle cell disease...
  77. ncbi Frequency of neonatal bilirubin testing and hyperbilirubinemia in a large health maintenance organization
    T B Newman
    Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California 94143, USA
    Pediatrics 104:1198-203. 1999
    To determine the frequency and interhospital variation of bilirubin testing and identified hyperbilirubinemia in a large health maintenance organization.
  78. ncbi Variations in the UDP-glucuronosyltransferase 1A1 gene for the development of unconjugated hyperbilirubinemia in Taiwanese
    Yang Yang Huang
    Department of Laboratory Medicine, Cathay General Hospital, No 280, Section 4, Jen Ai Road, Taipei 106, Taiwan
    Pharmacogenomics 9:1229-35. 2008
    ..3279T>G in the UDP-glucuronosyltransferase (UGT)1A1 gene could be a further factor for the development of hyperbilirubinemia. However, this variant has not been reported in the Taiwanese population.
  79. ncbi Co-inherited Gilbert's syndrome: a factor determining hyperbilirubinemia in homozygous beta-thalassemia
    R Galanello
    Istituto di Clinica e Biologia dell Età Evolutiva, Universita degli Studi di Cagliari, Ospedale Regionale Microcitemie, Italy
    Haematologica 84:103-5. 1999
    ..In this paper we tested the hypothesis related to the variability of the glucuronidation bilirubin rate which depends on the configuration of the A(TA)nTAA motif of the UGT1*1 glucuronosyltransferase gene promoter...
  80. ncbi Amphotericin B-associated hyperbilirubinemia: case report and review of the literature
    Jacqueline L Olin
    Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy Rutgers, State University of New Jersey, Piscataway 08854 8020, USA
    Pharmacotherapy 26:1011-7. 2006
    A 53-year-old woman with an intraabdominal infection secondary to Candida albicans experienced hyperbilirubinemia after receiving amphotericin B in two different formulations--amphotericin B deoxycholate and amphotericin B lipid complex...
  81. ncbi Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia
    Margalida Rotger
    Institute of Microbiology and Service of Infectious Diseases, University of Lausanne, Lausanne, Switzerland
    J Infect Dis 192:1381-6. 2005
    Unconjugated hyperbilirubinemia results from Gilbert syndrome and from antiretroviral therapy (ART) containing protease inhibitors...
  82. ncbi Donor blood glucose 6-phosphate dehydrogenase deficiency reduces the efficacy of exchange transfusion in neonatal hyperbilirubinemia
    Sandip Samanta
    Neonatal Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Pediatrics 123:e96-e100. 2009
    ..of exchange transfusion with glucose 6-phosphate dehydrogenase-deficient blood in neonates with idiopathic hyperbilirubinemia on postexchange total serum bilirubin levels, duration of phototherapy, and need for repeat exchange ..
  83. ncbi Treatment of Crigler-Najjar Syndrome type 1 by hepatic progenitor cell transplantation: a simple procedure for management of hyperbilirubinemia
    A A Khan
    Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital and Research Center, Hyderabad, India
    Transplant Proc 40:1148-50. 2008
    Crigler-Najjar Syndrome (CNS) is characterized by mild, chronic unconjugated hyperbilirubinemia resulting from an autosomal-recessive inherited deficiency of hepatic uridine/diphosphoglucuronate-glucuronosyl transferase 1Al since birth...
  84. ncbi Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1
    Sonia Rodriguez Novoa
    Clinical Pharmacokinetic Unit, Hospital Carlos III, Madrid, Spain
    Clin Infect Dis 42:291-5. 2006
    ..Plasma levels of atazanavir were significantly higher in patients with genotype CC than in those with CT or TT, and bilirubin levels correlated with atazanavir concentrations...
  85. ncbi Effective oral treatment of unconjugated hyperbilirubinemia in Gunn rats
    Anja M Hafkamp
    Division of Pediatric Gastroenterology, Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands
    Hepatology 41:526-34. 2005
    We sought to develop an oral treatment for unconjugated hyperbilirubinemia. In the Gunn rat model of unconjugated hyperbilirubinemia, dietary supplementation with the lipase inhibitor orlistat (Orl) or with calcium phosphate (CaP) ..
  86. pmc Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector
    Gabriele Toietta
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:3930-5. 2005
    Crigler-Najjar syndrome is a recessively inherited disorder characterized by severe unconjugated hyperbilirubinemia caused by a deficiency of uridine diphospho-glucuronosyl transferase 1A1...
  87. ncbi Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemia
    Sonia Rodriguez-Novoa
    Pharmacokinetic and Pharmacogenetic Unit, Hospital Carlos III, Madrid, Spain
    AIDS 21:41-6. 2007
    b>Hyperbilirubinemia is frequently seen in patients treated with atazanavir (ATV)...
  88. ncbi Reversible grade 4 hyperbilirubinemia in a patient with UGT1A1 7/7 genotype treated with irinotecan and cetuximab
    Bhavna Gupta
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Colorectal Cancer 6:447-9. 2007
    ..However, severe hyperbilirubinemia (grade 3/4) has not been previously reported in association with this chemotherapeutic agent...
  89. ncbi UGT1A1 promoter polymorphism increases risk of nilotinib-induced hyperbilirubinemia
    J B Singer
    Clinical Pharmacogenetics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
    Leukemia 21:2311-5. 2007
    ..bilirubin in humans, and a polymorphism in the promoter of the gene that encodes it has been associated with hyperbilirubinemia during treatment with a number of drugs...
  90. pmc Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia
    M Kaplan
    Department of Neonatology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Proc Natl Acad Sci U S A 94:12128-32. 1997
    ..UDPGT1), associated with benign jaundice in adults (Gilbert syndrome), increases the incidence of neonatal hyperbilirubinemia in G-6-PD deficiency...
  91. ncbi UGT1A1 polymorphism and hyperbilirubinemia in a patient who received sorafenib
    Judith Meza-Junco
    Department of Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, AB T6G 1Z2, Canada
    Cancer Chemother Pharmacol 65:1-4. 2009
    To report a single case of uridine glucuronosyltransferase 1A1 (UGT1A1) polymorphism and hyperbilirubinemia in a patient who received sorafenib.
  92. ncbi Seven novel mutations of the UGT1A1 gene in patients with unconjugated hyperbilirubinemia
    Maria D'Apolito
    Haematologica 92:133-4. 2007
    ..to identify new pathogenic variations of the UGT1A1 gene in 11 patients diagnosed with neonatal unconjugated hyperbilirubinemia. We describe two cases in which clinically unapparent heterozygotic mutations in the UGT1A1 gene may become ..
  93. ncbi Effective second-line treatment with cetuximab and bevacizumab in a patient with hepatic metastases of colorectal cancer and hyperbilirubinemia
    Nicolas Moosmann
    Medizinische Klinik III, Campus Grosshadern, Klinikum der Ludwig Maximilians Universität München, Germany
    Onkologie 30:509-12. 2007
    ..Irinotecan-based second-line chemotherapy of metastatic colorectal cancer (CRC) is effective, it might, however, be contraindicated in cases of severe liver dysfunction due to advanced liver metastases...
  94. ncbi A Gilbert's syndrome UGT1A1 variant confers susceptibility to tranilast-induced hyperbilirubinemia
    T M Danoff
    Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Philadelphia, PA, USA
    Pharmacogenomics J 4:49-53. 2004
    ..To identify the potential genetic factors that may account for the drug-induced hyperbilirubinemia, we examined polymorphisms in the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene in over a ..
  95. ncbi Incidence, course, and prediction of hyperbilirubinemia in near-term and term newborns
    S Umit Sarici
    Division of Neonatology, Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey
    Pediatrics 113:775-80. 2004
    In this study, we investigated prospectively the incidence of significant hyperbilirubinemia and demographic and laboratory characteristics and pattern of serum bilirubin levels of near-term newborns (35-37 weeks' [245-265 days'] ..
  96. ncbi Involvement of UDP-glucuronosyltransferase activity in irinotecan-induced delayed-onset diarrhea in rats
    Masaharu Onoue
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi shi, Tokyo, 186 8650, Japan
    Cancer Chemother Pharmacol 61:595-605. 2008
    ..In the clinic, great care is needed when using chemotherapy with CPT-11 in patients with poor UGT activity...
  97. ncbi Management of hyperbilirubinemia in biliary atresia by hepatic progenitor cell transplantation through hepatic artery: a case report
    A A Khan
    Center for Liver Research and Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital and Research Center, Hyderabad, India
    Transplant Proc 40:1153-5. 2008
    ..As the procedure is simple and the patient has tolerated the infusion therapy, it might be repeated to manage biliary atresia...
  98. ncbi Prediction of hyperbilirubinaemia in the healthy term newborn
    X Carbonell
    Hospital Clinic-Maternitat, , , IDIBAPS, Universitat de Barcelona, Spain
    Acta Paediatr 90:166-70. 2001
    ..Conclusion: There is a good correlation between TCB and TSB. In infants with TSB > or = 102 mcmol/L at 24 h or TSB > or = 154 mcmol/L or transcutaneous readings > or = 13 h at 48 h, a TSB test must be performed after 48 h of life...
  99. ncbi Urinary tract infections in infants: comparison between those with conjugated vs unconjugated hyperbilirubinaemia
    Hung Chang Lee
    Department of Paediatrics, Mackay Memorial Hospital, Taiwan Department of Paediatrics, Taipei Medical Uinversity, Taiwan
    Ann Trop Paediatr 25:277-82. 2005
    ..The aim was to investigate conjugated and unconjugated hyperbilirubinaemia in association with urinary tract infection (UTI) in young infants...
  100. ncbi Prevention of bilirubin encephalopathy
    G Bertini
    Department of Critical Care Medicine and Surgery, Neonatal Intensive Care Unit, Careggi University Hospital, Florence, Italy
    Biol Neonate 79:219-23. 2001
    ..of bilirubin encephalopathy is based on the detection of infants at risk of developing a significant hyperbilirubinemia. This task can be accomplished by performing a simple umbilical cord blood test, such as blood group, Rh, ..
  101. ncbi Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups
    Monica J Daood
    Department of Pediatrics, Division of Newborn Medicine, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Res 60:44-9. 2006
    ....

Research Grants62

  1. Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe Jaundice
    Sanjiv B Amin; Fiscal Year: 2010
    ..experienced audiologists, blinded to unbound bilirubin levels, at three different time periods: 1) time of hyperbilirubinemia 2) 2 months corrected age and 3) 9 months corrected age...
  2. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
    ..preparation will permit sufficient repopulation of the livers of the Gunn rat model of CN1 to ameliorate hyperbilirubinemia. The specific aim 1 is (a) Generating and characterizing iPS cells from skin fibroblasts from normal ..
  3. Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening
    Vijay Srinivasan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Severe hyperbilirubinemia (defined as serum bilirubin levels greater than 99th percentile) can cause a spectrum of neurologic dysfunction, of which kernicterus has the most devastating neurologic ..
  4. Xenobiotic sensors PXR and CAR and regulation of the UGT1 locus
    Robert H Tukey; Fiscal Year: 2012
    ..these mice will be exploited to study the role of PXR and CAR towrds controlling UGT1A1 gene expression and hyperbilirubinemia. To this end, the specific aims of this competitive renewal are 1...
  5. Risk factors for encephalopathy in newborns with severe hyperbilirubinemia
    RICHARD PARTRIDGE WENNBERG; Fiscal Year: 2010
    The American Academy of Pediatrics guidelines for intervention in patients with hyperbilirubinemia (total serum bilirubin concentration [TSB] modified by clinical factors) are based on sparse published clinical evidence and do not ..
  6. Late adverse Impact of Getting Hyperbilrubinemia or photo Therapy (LIGHT) study
    Thomas B Newman; Fiscal Year: 2013
    ..The Late adverse Impact of Getting Hyperbilirubinemia or photoTherapy (LIGHT) study will fill two key knowledge gaps that prevent evidence- based treatment of ..
  7. Neonatal hyperbilirubinemia in a humanized UGT1 animal model
    Robert H Tukey; Fiscal Year: 2013
    ..Clinically and in selective genetic deficiencies, severe hyperbilirubinemia leads to bilurubin toxicity, which is classified as kernicterus or the depositing of bilirubin into the ..
  8. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Uncontrolled hyperbilirubinemia (jaundice) in neonates has long been known to lead to neurological dysfunction including irreversible athetoid cerebral palsy with speech, ocular and hearing ..
  9. Development of a Point-Of-Care Test for Determining Bilirubin in Whole Blood
    PETER MICHAEL GAVIN; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Neonatal hyperbilirubinemia (excessive bilirubin) is one of the most common problems encountered in newborns. If caught in time, hyperbilirubinemia can be treated...
  10. Multiplex platform for point of care newborn screening of hyperbilirubinemia
    NICHOLAS TROTTA; Fiscal Year: 2013
    ..Thus, severe neonatal hyperbilirubinemia has been nominated for inclusion on the uniform newborn screening panel in the US...
  11. A pilot study of moderate hyperbilirubinemia in type 1 diabetes mellitus
    Todd Perlstein; Fiscal Year: 2011
    ..proposed pilot study aims to be the first step in developing a novel treatment strategy of inducing moderate hyperbilirubinemia for preventing the vascular complications of type 1 diabetes mellitus (T1DM)...
  12. Rochester-Buffalo Neonatal Research Group
    CARL T D'ANGIO; Fiscal Year: 2013
    ..well-designed clinical trials, with recent randomized clinical trials in the areas of neuroprotection, hyperbilirubinemia, inhaled nitric oxide, and supplemental oxygen and respiratory management...
  13. MATURATION OF LIVER FOR THE METABOLISM OF BILIRUBIN
    Glenn Gourley; Fiscal Year: 1993
    ..Such clinical circumstances result in non- conjugated hyperbilirubinemia which can be either lethal or in surviving infants produce a bilirubin encephalopathy characterized by ..
  14. Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening
    Vijay Srinivasan; Fiscal Year: 2009
    ..health campaigning and strict guidelines for diagnosis and treatment, the estimated incidence of severe hyperbilirubinemia (defined as serum bilirubin levels greater than 99th percentile) is 1:70...
  15. Neonatal Phototherapy / Bilirubin Excretion
    DAVID LIGHTNER; Fiscal Year: 2007
    ..the most common clinical diagnosis in the newborn, with 60% of neonates displaying significant unconjugated hyperbilirubinemia during the first 3 days of life...
  16. Bilirubin and Photobilirubin: Metabolism & Exretion
    Antony McDonagh; Fiscal Year: 2005
    ..The work will lead to safer more effective treatment of familial hyperbilirubinemia and jaundice in the newborn.
  17. GENE EXPRESIION WITH ADENOVIRUS-MEDIATED TRANSFER
    Frederick Askari; Fiscal Year: 2001
    ..adenoviral liver directed gene therapy in the Gunn rat animal model of congenital non-hemolytic unconjugated hyperbilirubinemia, this proposal is linked to K08 DK02438...
  18. BRAIN GLUTATHIONE S-TRANSFERASES AND NEUROTOXICITY
    Jeffrey Johnson; Fiscal Year: 2000
    ..HPLC analysis of GSTs in jaundiced (jj) rats revealed that hyperbilirubinemia increased the concentration of Mu- class GST subunit 4 (yb2) preferentially in the flocculus and lateral ..
  19. Development of a Point-Of-Care Test for Determining Bilirubin in Whole Blood
    WAI LAW; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Neonatal hyperbilirubinemia (excessive bilirubin) is one of the most common problems encountered in newborns. If caught in time, hyperbilirubinemia can be treated...
  20. INHERITED DISORDERS OF HEPATIC BILIRUBIN GLUCORONIDATION
    Namita Roy Chowdhury; Fiscal Year: 2006
    ..Since several drugs cause hyperbilirubinemia by inhibiting UGT1A1 activity, we will delineate domains involved in binding the substrtes, UDPGA and ..
  21. IMMUNE RESPONSE TO ADENOVIRAL GENE TRANSFER
    Frederick Askari; Fiscal Year: 2000
    ..liver directed gene therapy in the Gunn rat animal model of congenital non- hemolytic unconjugated hyperbilirubinemia. Crigler-Najjar syndrome type I, familial non-hemolytic jaundice and kernicterus, is a fatal disease which ..
  22. INHERITED DISORDERS OF BILIRUBIN GLUCURONIDATION
    Jayanta Roy Chowdhury; Fiscal Year: 1991
    ..Inherited disorders with defective UDPGT function are associated with unconjugated hyperbilirubinemia; in severe cases (e.g...
  23. HYPERBILIRUBINEMIA TREATMENT WITH CLONED THERMO-ENZYMES
    Larry Allen; Fiscal Year: 1993
    ..Currently, ThermoGen is communicating with established pharmaceutical companies for jointly entering into these trails...
  24. USE OF AN LED ARRAY FOR NEONATAL PHOTOTHERAPY
    DANIELLE ROSEN; Fiscal Year: 2000
    b>Hyperbilirubinemia (Jaundice) affects many term and most preterm infants. When infants are exposed to blue light (410 to 460 nanometers), a photochemical reaction occurs in the skin...
  25. MECHANISM TO LIMIT CNS BILIRUBIN INFLUX: P-GLYCOPROTEIN
    Jon Watchko; Fiscal Year: 1999
    DESCRIPTION (Adapted from the Applicant's Description): Unconjugated hyperbilirubinemia is the most common clinical condition in the newborn period...
  26. DEVELOPMENT SUBSEQUENT TO JAUNDICE OF THE NEWBORN
    JEAN JEW; Fiscal Year: 1980
    ..examination of morphological and behavioral changes - including hypothesized recovery processes - after hyperbilirubinemia, are planned under controlled laboratory conditions...
  27. HEME AND SULFITE METABOLISM IN AMPHIBIANS
    Antony McDonagh; Fiscal Year: 1993
    ..The studies may suggest new approaches for the treatment of familial unconjugated hyperbilirubinemia and the prevention of jaundice in newborn babies.
  28. Multiple Mechanisms of Hepatoprotective Mrp3 Induction
    Nathan Cherrington; Fiscal Year: 2005
    ..Additionally, other outcomes of cholestasis include an increase in oxidative stress, hyperbilirubinemia, inflammation and cytokine releasc, all of which, individually, effect the regulation of xenobiotic ..
  29. MANAGEMENT OF HYPERBILIRUBINEMIA IN NEWBORNS
    Attallah Kappas; Fiscal Year: 2000
    This project is a follow-on to a clinical trial for the "Management of Hyperbilirubinemia in the Newborn"...
  30. A Fluorescent Assay for Free Unconjugated Bilirubin
    J Kampf; Fiscal Year: 2005
    Current diagnostic tests for severe neonatal hyperbilirubinemia do not correlate well with bilirubinencephalopathy in newboms, contributing to uncertainty in the management of jaundiced infants...
  31. RAPID DETECTION OF PRE-AND NEONATAL METABOLIC DISORDERS
    EUGENE WATSON; Fiscal Year: 2001
    ..of bilirubin, a metabolite which is an indicator for a variety of metabolic disorders, including hyperbilirubinemia in infants...
  32. NEONATAL BILIRUBIN NEUROTOXICITY AND P-GLYCOPROTEIN
    Jon Watchko; Fiscal Year: 2007
    ..CNS parenchyma as well as cells of the BBB in humans; and 3) CNS Pgp expression is upregulated by postnatal hyperbilirubinemia and antenatal maternal vitamin A treatment in Gunn rat pups, and that combined antenatal vitamin A treatment ..
  33. Bilirubin-induced Auditory Neuropathy in Preterms
    SANJIV AMIN; Fiscal Year: 2008
    ..incidence and determinants of bilirubin-induced auditory neuropathy (AN) in high-risk premature infants with hyperbilirubinemia. AN was first reported in 1996...
  34. REGULATION OF HEME OXYGENASE IN NEONATAL ANIMALS
    David Stevenson; Fiscal Year: 2005
    ..abstract_text> ..
  35. Chromium Mesoporphyrin in the Prevention of Neonatal Jaundice
    David K Stevenson; Fiscal Year: 2010
    ..b>Hyperbilirubinemia is exacerbated by hemolytic diseases, such as Rhesus isoimmunization and ABO incompatibility, which result ..
  36. Effects of Statins on Heme Oxygenase-1 Regulation
    David Stevenson; Fiscal Year: 2008
    ..to delineate the role of HO-1 as a novel therapeutic target for statins and mediator of protective effects under conditions of insuffi- cient HO-1 expression such as pre-eclampsia and other pregnancy-related disorders ..
  37. Therapeutic Use of Heme Analogs: Absorption in Intestine
    David Stevenson; Fiscal Year: 2009
    Neonatal jaundice occurs in 60-70% of all newborn infants. It is due to hyperbilirubinemia caused not only by an overproduction of bilirubin, but also by a transient failure to excrete this metabolite...
  38. BILIRUBIN TOXICITY IN THE AUDITORY SYSTEM
    Steven Shapiro; Fiscal Year: 2005
    ..dysfunction continue to be major complications of bilirubin toxicity despite advances in the treatment of hyperbilirubinemia (jaundice) in newborns...
  39. Improving Survival For Small-For-Size Liver Grafts
    Zhi Zhong; Fiscal Year: 2004
    ..This work will develop mechanism-based strategies to increase the use and improve the outcome of partial livers for transplantation in the clinic. ..
  40. Mechanisms of In Vivo Ethanol-Induced Mitochondrial Depolarization
    Zhi Zhong; Fiscal Year: 2010
    ....
  41. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ....
  42. Prediciting Severe Neonatal Hyperbilirubinemia
    Ron Keren; Fiscal Year: 2007
    ..newborn screening and disease prevention in general, and to the prediction and prevention of severe neonatal hyperbilirubinemia and kernicterus in particular. The specific aims of the research application are three-fold...
  43. Dystonia in an Animal Model of Kernicterus
    Steven Shapiro; Fiscal Year: 2007
    ..disorders continue to be major complications of bilirubin toxicity despite advances in the treatment of hyperbilirubinemia (jaundice) in newborns...
  44. MATERNAL ALCOHOL IMPAIRS FETAL ALVEOLAR MACROPHAGE
    THERESA GAUTHIER; Fiscal Year: 2002
    ..Understanding the modulatory role of GSH availability in AM function will broaden our understanding of GSH supplements not only as a possible therapy for infants exposed to ETOH in utero but premature infants in general. ..
  45. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  46. Heparan Sulfate Proteoglycans and HIV Pathogenesis
    Philippe Gallay; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  47. GESTATIONAL DIABETES: DIAGNOSTIC CRITERIA AND OUTCOMES
    Assiamira Ferrara; Fiscal Year: 2003
    ..are associated with increased risk of selected perinatal complications: infant severe macrosomia, severe hyperbilirubinemia, hypoglycemia, respiratory distress syndrome, and maternal preeclampsia/eclampsia...
  48. Cerebral Hemorrhage Model: Mechanisms and Treatments
    Kenneth Wagner; Fiscal Year: 2005
    ..abstract_text> ..
  49. GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENS
    Robert Tukey; Fiscal Year: 2002
    ....
  50. Molecular Biology of Erythrocyte Ankyrin
    Patrick G Gallagher; Fiscal Year: 2010
    ..These studies may provide important information to be used for diagnosis and treatment of patients with this disorder. ..
  51. Comparative effectiveness of diabetes prevention strategies in women with GDM
    Assiamira Ferrara; Fiscal Year: 2010
    ..Finding that this intervention is cost-effective in this setting should motivate its adoption at KP as well as in other health care systems. ..
  52. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
    ..Defining the immunopathology in biliary atresia will lead to a better understanding of the etiopathogenesis and provide insight into future therapeutic options. ..
  53. Prenatal Exposure to Polyfluoroalkyl Compounds in the EMA Study
    Lisa A Croen; Fiscal Year: 2010
    ..In the long-term, a better understanding of the underlying biology may suggest appropriate strategies for early intervention and contribute to the eventual prevention of this often devastating and usually life-long disability. ..
  54. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  55. Rare Liver Disease Network
    Ronald Sokol; Fiscal Year: 2005
    ..The RLDN will be a full partner in the Rare Diseases Clinical Research Network and will participate collaboratively with the other Clinical Research Centers and the Data and Technology Coordinating Center. ..
  56. c-Kit Activating Mutations and Drug Resistance in AML
    Robert Arceci; Fiscal Year: 2005
    ..These data may also be useful for stratification of patients according to cytokine receptor mutations and subsequent treatment with non-genotoxic therapies that target specific biological pathways. ..
  57. Biliary Microlithiasis in Alcohol Induced Pancreatitis
    Arun Sanyal; Fiscal Year: 2007
    ..The long-term goal is to use data from this R21 proposal to develop a RO1 proposal about a large scale phase III clinical trial of UDCA for alcohol-induced pancreatitis. [unreadable] [unreadable] [unreadable]..