Genomes and Genes
Summary: Pathologic process consisting of an abnormal increase in the amount of BILIRUBIN in the circulating BLOOD, which may result in JAUNDICE.
Publications249 found, 100 shown here
- Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemiaSerena Sanna
Istituto di Neurogenetica e Neurofarmacologia del Consiglio Nazionale delle Ricerche, Monserrato, 09042 Cagliari, Italy
Hum Mol Genet 18:2711-8. 2009..We also show that SLC01B3 variants contribute to idiopathic mild unconjugated hyperbilirubinemia. Thus, SLC01B3 appears to be involved in the regulation of serum bilirubin levels in healthy individuals and ..
- Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in miceTrinity Vera
Dept of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
Am J Physiol Regul Integr Comp Physiol 297:R738-43. 2009Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension...
- Hyperbilirubinemia and neurodevelopmental outcome of very low birthweight infants: results from the LIFT cohortGaël Mazeiras
Department of Neonatal Medicine, St Leon Hospital, Bayonne, France
PLoS ONE 7:e30900. 2012..Bilirubin-related neurotoxicity is an important clinical issue in very low birthweight (VLBW) infants, and the existing literature is inconsistent...
- Genetic factors influencing severe atazanavir-associated hyperbilirubinemia in a population with low UDP-glucuronosyltransferase 1A1*28 allele frequencyWan Beom Park
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
Clin Infect Dis 51:101-6. 2010High prevalence of severe atazanavir-associated hyperbilirubinemia in Asians with low prevalence of the UDP-glucuronosyltransferase (UGT)1A1*28 polymorphism suggests the importance of genetic factors other than UGT1A1*28 for atazanavir-..
- Understanding severe hyperbilirubinemia and preventing kernicterus: adjuncts in the interpretation of neonatal serum bilirubinMichael Kaplan
Department of Neonatology, Shaare Zedek Medical Center, P O Box 3235, Jerusalem 91031, Israel
Clin Chim Acta 356:9-21. 2005..b>Hyperbilirubinemia develops when bilirubin production exceeds the body's capacity to excrete it, primarily by conjugation...
- Analysis of the A(TA)(n)TAA configuration in the promoter region of the UGT1 A1 gene in Greek patients with thalassemia intermedia and sickle cell diseaseVassiliki Kalotychou
First Department of Medicine, University of Athens School of Medicine, Laikon General Hospital, 11527, Athens, Greece
Blood Cells Mol Dis 31:38-42. 2003Gilbert's syndrome is characterized by mild unconjugated hyperbilirubinemia. The molecular basis of this syndrome usually concerns an additional dinucleotide insertion (TA) in the A(TA)(n)TAA configuration residing in the promoter region ..
- Moderate hyperbilirubinemia improves renal hemodynamics in ANG II-dependent hypertensionTrinity Vera
Dept of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, 39216 4505, USA
Am J Physiol Regul Integr Comp Physiol 299:R1044-9. 2010We have previously demonstrated that moderate hyperbilirubinemia decreases blood pressure in ANG II-dependent hypertension through mechanisms that decrease oxidative stress and increase nitric oxide levels...
- Correction of hyperbilirubinemia in gunn rats using clinically relevant low doses of helper-dependent adenoviral vectorsDavid Dimmock
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Gene Ther 22:483-8. 2011..of uridine diphospho-glucuronosyl transferase 1A1 (UGT1A1) and results in life-threatening unconjugated hyperbilirubinemia. Lifelong correction of hyperbilirubinemia by liver-directed gene therapy using a helper-dependent ..
- Liver transplantation using grafts of living donors with isolated unconjugated hyperbilirubinemia: a matched case-control studySang Bin Han
Department of Anesthesiology and Pain Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
Transpl Int 26:623-30. 2013..Elevated unconjugated bilirubin with otherwise normal, so-called isolated unconjugated hyperbilirubinemia (IUHB), is encountered frequently in living liver donor evaluation...
- Methylene blue-induced hyperbilirubinemia in neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiencyT W Gauthier
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Matern Fetal Med 9:252-4. 2000..Two neonates were subsequently diagnosed with G6PD deficiency. Continued caution is warranted prior to the use of methylene blue in the gravid female...
- An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibilityS Umit Sarici
Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine Ihsan Doğramaci Children s Hospital, Ankara, Turkey
Pediatrics 109:e53. 2002..newborns with ABO incompatibility are at especially greater risk for developing a subsequent significant hyperbilirubinemia because some of these infants also may present with some degree of ABO isoimmune disease...
- Drug-induced hyperbilirubinemia and the clinical influencing factorsYoung Mi Ah
Department of Pharmacy, Seoul National University Hospital, Seoul, Korea
Drug Metab Rev 40:511-37. 2008b>Hyperbilirubinemia may accompany harmful effects such as jaundice, brain dysfunction, and pharmacokinetic alterations of drugs...
- Genetic factors related to unconjugated hyperbilirubinemia amongst adultsChing Shan Huang
Department of Medical Technology, Fooyin University, Kaohsiung, Taiwan
Pharmacogenet Genomics 15:43-50. 2005..in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene are involved in the development of unconjugated hyperbilirubinemia. We hypothesize that other genetic factors may also be associated with this disease...
- Clinical implication of the difference between transcutaneous bilirubinometry and total serum bilirubin for the classification of newborns at risk of hyperbilirubinemiaKarina Rodriguez-Capote
Pathology and Laboratory Medicine, McMaster University Medical Centre, Hamilton, ON, Canada
Clin Biochem 42:176-9. 2009....
- Intravenous immunoglobulin G (IVIG) therapy for significant hyperbilirubinemia in ABO hemolytic disease of the newbornA M Miqdad
Department of Pediatrics, Security Forces Hospital, Riyadh, Saudi Arabia
J Matern Fetal Neonatal Med 16:163-6. 2004Although intravenous immunoglobulin G (IVIG) therapy has been reported in hyperbilirubinemia of Rh hemolytic disease, its use in ABO hemolytic disease has been reported in only a few studies...
- Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemiaScott D Campbell
Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton Laboratory, Eastern Point Road, MS 8118W 131, Groton, CT 06340, USA
Chem Biol Interact 150:179-87. 2004..fraction of OATP1B1 inhibited at the clinical exposure level correlated very well with the observed hyperbilirubinemia outcome for these drugs in humans...
- Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locusRyoichi Fujiwara
Laboratory of Environmental Toxicology, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 107:5024-9. 2010..in adults is Gilbert's syndrome, which is characterized by an allelic polymorphism in the UGT1A1 promoter, hyperbilirubinemia was monitored in humanized UGT1 mice that expressed either the Gilbert's UGT1A1*28 allele [Tg(UGT1(A1*28))..
- Hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient male newborns in Al-Ahsa, Saudi ArabiaSameer Y Al-Abdi
Department of Pediatrics, Neonatology Division, MC 315, King Abdulaziz Hospital for National Guard, PO Box 2477, Al Ahsa 31982, Kingdom of Saudi Arabia
Saudi Med J 31:175-9. 2010To study the clinical and laboratory characteristics of hyperbilirubinemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient male newborns from Al-Ahsa area (Ahsais).
- A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomesMaria Alexandra Brito
Centro de Patogénese Molecular UBMBE, Faculdade de Farmacia, University of Lisbon, Av das Forcas Armadas, 1600 083 Lisbon, Portugal
Brain Res 1026:33-43. 2004..bilirubin with synaptosomal membrane vesicles leads to oxidative injury, loss of membrane asymmetry and functionality, and calcium intrusion, thus potentially contributing to the pathogenesis of encephalopathy by hyperbilirubinemia.
- Hyperbilirubinemia among African American, glucose-6-phosphate dehydrogenase-deficient neonatesMichael Kaplan
Department of Neonatology, Shaare Zedek Medical Center, PO Box 3525, Jerusalem 91031, Israel
Pediatrics 114:e213-9. 2004Although glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is prevalent in African Americans, their risk of associated neonatal hyperbilirubinemia has not been prospectively studied.
- Hyperbilirubinemia reduces the streptozotocin-induced pancreatic damage through attenuating the oxidative stress in the Gunn ratYan Yan Fu
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Tohoku J Exp Med 222:265-73. 2010..We examined the effect of hyperbilirubinemia on the pancreatic damage caused by streptozotocin (STZ) in the Gunn rat...
- Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: a favorable endogenous responseRamesh Kumar
Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi 110070, India
Clin Biochem 45:272-4. 2012The clinical significance of increased frequency of unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease (NAFLD) is unknown...
- Sorafenib is an inhibitor of UGT1A1 but is metabolized by UGT1A9: implications of genetic variants on pharmacokinetics and hyperbilirubinemiaCody J Peer
Clinical Pharmacology Program, Pharmacology and Experimental Therapeutics Section, Molecular Pharmacology Section, Biostatistics and Data Management Branch, Medical Oncology Branch, and HIV AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA
Clin Cancer Res 18:2099-107. 2012Several case reports suggest sorafenib exposure and sorafenib-induced hyperbilirubinemia may be related to a (TA)(5/6/7) repeat polymorphism in UGT1A1*28 (UGT, uridine glucuronosyl transferase)...
- Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoterJunko Sugatani
Department of Pharmaco Biochemistry, Global Center of Excellence for Innovation in Human Health Sciences, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
Naunyn Schmiedebergs Arch Pharmacol 377:597-605. 2008..Thus, UGT1A1 gene promoter variations, including the TA repeat polymorphism and T-3279G gtPBREM, have important clinical implications...
- Evidence for higher red blood cell mass in persons with unconjugated hyperbilirubinemia and Gilbert's syndromeYahya Buyukasik
Department of Hematology, Hacettepe University School of Medicine, Ankara, Turkey
Am J Med Sci 335:115-9. 2008..The genetic polymorphism responsible from Gilbert's syndrome is not sufficient for the clinical phenotype to occur in many persons. Additional factors are believed to contribute in pathogenesis. Red cell mass may be such a factor...
- Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotesM Kaplan
Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel
Pediatrics 104:68-74. 1999We assessed the incidence of hyperbilirubinemia, defined as serum total bilirubin >/=15 mg/dL (256 micromol/L), in a cohort of Sephardic Jewish female neonates at risk for glucose-6-phosphate dehydrogenase (G-6-PD) deficiency with ..
- The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and manC C Paulusma
Department of Gastrointestinal and Liver Diseases, Center for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
J Mol Med 75:420-8. 1997..The human Dubin-Johnson syndrome is an autosomal recessive liver disease characterized by a chronic conjugated hyperbilirubinemia. Patients have impaired hepatobiliary transport of many endogenous and xenobiotic compounds...
- Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndromeTatsuya Maruhashi
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
Circulation 126:598-603. 2012Patients with Gilbert syndrome have mild unconjugated hyperbilirubinemia. It has been shown that bilirubin is an endogenous antioxidant...
- Fasting-related hyperbilirubinemia in rats: the effect of decreased intestinal motilityP Kotal
First Medical Department, Charles University, Prague, Czech Republic
Gastroenterology 111:217-23. 1996Fasting increases serum bilirubin levels in both humans and rats. Because the pathogenesis of fasting hyperbilirubinemia is not fully understood, the effect of fasting on disposition of bile pigments was investigated in rats.
- Beyond plasma bilirubin: the effects of phototherapy and albumin on brain bilirubin levels in Gunn ratsFrans J C Cuperus
Pediatric Gastroenterology and Hepatology, Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, Beatrix Children s Hospital University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Hepatol 58:134-40. 2013Severe unconjugated hyperbilirubinemia, as occurs in Crigler-Najjar disease and neonatal jaundice, carries the risk of neurotoxicity...
- Plasma fatty acids in premature infants with hyperbilirubinemia: before-and-after nutrition support with fish oil emulsionCatherine J Klein
Childrens National Medical Center, Washington, DC 20010, USA
Nutr Clin Pract 28:87-94. 2013..76 ± 1.68 kg) transitioning to enteral feeding rather than for resolution of hyperbilirubinemia (direct bilirubin 7.9 ± 4.8 mg/dL)...
- Risk of hyperbilirubinemia in breast-fed infantsPi Feng Chang
Department of Pediatrics, Far Eastern Memorial Hospital, Pan Chiao, Taipei, Taiwan
J Pediatr 159:561-5. 2011To investigate the risk factors for hyperbilirubinemia in infants who are exclusively breast-fed.
- The effects of antipsychotics on behavioral abnormalities of the Gunn rat (unconjugated hyperbilirubinemia rat), a rat model of schizophreniaKeiko Tsuchie
Department of Psychiatry, Faculty of Medicine, Shimane University, Japan
Asian J Psychiatr 6:119-23. 2013There have been reports of a positive relationship between schizophrenia and hyperbilirubinemia. Patients with schizophrenia show a significantly higher frequency of hyperbilirubinemia than patients suffering from other psychiatric ..
- Management of hyperbilirubinemia in newborns: measuring performance by using a benchmarking modelShu Chiung Chou
Center for Quality of Care Research and Education, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Pediatrics 112:1264-73. 2003Accreditors hold hospitals accountable for harm from serious newborn hyperbilirubinemia, yet standards for evaluating performance in prevention are lacking.
- A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's diseaseHilbert S de Vries
Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
J Crohns Colitis 6:597-602. 2012....
- Moderate hyperbilirubinemia induces a transient alteration of neonatal behaviorRoberto Paludetto
Division of Neonatology, Department of Pediatrics Federico II of Naples, Naples, Italy
Pediatrics 110:e50. 2002To investigate the behavioral changes induced by moderate hyperbilirubinemia in the otherwise healthy, untreated newborn infant.
- Unconjugated hyperbilirubinemia is inversely associated with non-alcoholic steatohepatitis (NASH)M Hjelkrem
Brooke Army Medical Center, Gastroenterology Service, Fort Sam Houston, TX, USA
Aliment Pharmacol Ther 35:1416-23. 2012..We believe that unconjugated hyperbilirubinemia may protect against development of non-alcoholic steatohepatitis (NASH).
- Prognostic value of direct bilirubin in neonatal hyperbilirubinemiaManju Mamtani
Lata Medical Research Foundation, Nagpur, India
Indian J Pediatr 74:819-22. 2007To determine the prognostic value of indirect and direct hyperbilirubinemia in neonates with jaundice.
- Effective treatment of unconjugated hyperbilirubinemia with oral bile salts in Gunn ratsFrans J C Cuperus
Pediatric Gastroenterology, Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Gastroenterology 136:673-82.e1. 2009We tested the hypothesis that oral administration of bile salts, which are known to increase the biliary excretion of unconjugated bilirubin (UCB), decreases unconjugated hyperbilirubinemia in the Gunn rat model.
- Postoperative hyperbilirubinemia after surgery for gastrointestinal perforationToshirou Nishida
Department of Surgery, Osaka Police Hospital, Kitayama cho, Tennouji ku, Japan
Surg Today 32:679-84. 2002The aim of this study was to evaluate the risk factors and outcome of patients with hyperbilirubinemia after surgery for generalized peritonitis.
- Modulated function of tissue efflux transporters under hyperbilirubinemia in ratsTomoharu Yokooji
Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5 1 1 Hiro koshingai, Kure, Hiroshima 737 0112, Japan
Eur J Pharmacol 636:166-72. 2010The effect of hyperbilirubinemia on the function of tissue efflux transporters such as multidrug resistance-associated proteins (Mrps) and organic anion transporting polypeptides (Oatps) was examined by measuring tissue accumulation of 2,..
- False-negative results of pre-discharge neonatal bilirubin screening to predict severe hyperbilirubinemia: a need for cautionJonathan Slaughter
Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
Eur J Pediatr 168:1461-6. 2009..using an hour-specific bilirubin nomogram, has been advocated to assess risk for subsequent severe hyperbilirubinemia. However, the false-negative rate has never been adequately studied...
- Parenteral nutrition-associated conjugated hyperbilirubinemia in hospitalized infantsCatherine J Klein
Bionutrition Research Program, Children s National Medical Center, and Department of Pediatrics, School of Washington, DC, USA
J Am Diet Assoc 110:1684-95. 2010Parenteral nutrition-associated conjugated hyperbilirubinemia (PNAC), commonly defined as direct bilirubin ≥2 mg/dL (34.2 μmol/L), is primarily a pediatric disease with premature infants being the most susceptible...
- Biliary sludge and hyperbilirubinemia associated with ceftriaxone in an adult: case report and review of the literatureCourtney L Bickford
College of Pharmacy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Pharmacotherapy 25:1389-95. 2005..Clinicians need to be aware of the association of ceftriaxone and biliary pseudolithiasis and hyperbilirubinemia, and monitor accordingly.
- A new animal model of hemolytic hyperbilirubinemia-induced bilirubin encephalopathy (kernicterus)Ann C Rice
Department of Neurology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Pediatr Res 64:265-9. 2008Neonatal hyperbilirubinemia can cause bilirubin encephalopathy (kernicterus)...
- Relationship between unconjugated hyperbilirubinemia and lipoprotein spectrumIvan Očadlík
2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Neuro Endocrinol Lett 32:360-4. 2011..The presence of LDL1 and LDL2 subpopulations, as well as HDL lipoproteins is considered as protective factor...
- Role of UGT1A1 mutation in fasting hyperbilirubinemiaT Ishihara
Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
J Gastroenterol Hepatol 16:678-82. 2001BACKGROUND AND AIM: Low-grade fasting hyperbilirubinemia is a common observation in healthy subjects (HS), whereas high-grade fasting hyperbilirubinemia is believed to be a characteristic finding of Gilbert's syndrome...
- [Benign recurrent intrahepatic cholestasis type-II--a rare cause of direct hyperbilirubinemia exacerbations with hepatic fibrosis]Meir Mizrahi
Hadassah Ein Karem Medical Center Jerusalem
Harefuah 147:381-3, 480. 2008Direct hyperbilirubinemia, may result from a variety of pathologies, including structural obstructions with biliary tract occlusions (as in cholelithiasis), infections (e.g...
- UGT1A1 promoter polymorphisms and the development of hyperbilirubinemia and gallbladder disease in children with sickle cell anemiaShannon L Carpenter
Division of Hematology Oncology, Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas 78207, USA
Am J Hematol 83:800-3. 2008..UGT1A1 genotyping should be considered as a screening tool for predicting children most likely to develop gallbladder disease at a young age...
- Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia: genetic screening is unnecessaryRichard E Nettles
J Infect Dis 193:1611-2; author reply 1611-2. 2006
- A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newbornsA Kappas
Rockefeller University Hospital, New York, New York, USA
Pediatrics 108:25-30. 2001..normal neonates, G-6-PD-deficient neonates experienced a twofold increase in the prevalence of significant hyperbilirubinemia requiring phototherapy...
- Are moderate degrees of hyperbilirubinemia in healthy term neonates really safe for the brain?I Soorani-Lunsing
Department Neurology, University of Groningen, NL 9713 GZ Groningen, The Netherlands
Pediatr Res 50:701-5. 2001In 1994 the American Academy of Pediatrics recommended more liberal rules for the treatment of hyperbilirubinemia in healthy term newborns. Yet, the safety of moderate degrees of hyperbilirubinemia in healthy term newborns is debated...
- Sn-Mesoporphyrin interdiction of severe hyperbilirubinemia in Jehovah's Witness newborns as an alternative to exchange transfusionA Kappas
Rockefeller University, New York, NY 10021, USA
Pediatrics 108:1374-7. 2001..are Jehovah's Witness adherents lead them to reject the use of exchange transfusions as therapy for severe hyperbilirubinemia in newborns in whom intensive phototherapy has failed to control this problem...
- Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy--an extended haplotype of genetic variants increases risk in indinavir treatmentTim O Lankisch
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
J Hepatol 50:1010-8. 2009..Indinavir (IDV) can lead to hyperbilirubinemia in Gilbert's syndrome (UGT1A1*28), which does not explain interindividual severity differences and may thus ..
- Hyperbilirubinemia-related behavioral and neuropathological changes in rats: a possible schizophrenia animal modelMaiko Hayashida
Department of Psychiatry, Shimane University Faculty of Medicine, Japan
Prog Neuropsychopharmacol Biol Psychiatry 33:581-8. 2009Patients with schizophrenia show a significantly higher frequency of hyperbilirubinemia than patients suffering from other psychiatric disorders and the general healthy population...
- A patient with exacerbation of idiopathic pulmonary fibrosis which was resolved probably due to the coexisting hyperbilirubinemia?T Ohrui
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
Tohoku J Exp Med 193:245-9. 2001..This case suggests that bile pigments have some important roles in tissue protection against inflammatory damage in IPF, and may illustrate an important key for treatment of this fatal disorder...
- Diagnostic value of hyperbilirubinemia as a predictive factor for appendiceal perforation in acute appendicitisMichael Sand
Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr University, Bochum, Bergstr 26, 44791, Bochum, Germany
Am J Surg 198:193-8. 2009..This had led to the theory that hyperbilirubinemia in patients with appendicitis may have a predictive potential for the preoperative diagnosis of appendiceal ..
- Prediction of hyperbilirubinemia in near-term and term infantsD K Stevenson
Department of Pediatrics, Lucile Salter Packard Children's Hospital, Stanford, California, USA
Pediatrics 108:31-9. 2001..measurement or in combination with serum total bilirubin (STB) measurements, can predict the development of hyperbilirubinemia during the first 7 days of life...
- Mechanism of indinavir-induced hyperbilirubinemiaS D Zucker
Division of Digestive Diseases and Division of Infectious Diseases, University of Cincinnati, Cincinnati, OH 45267, USA
Proc Natl Acad Sci U S A 98:12671-6. 2001Indinavir is a viral protease inhibitor used for the treatment of HIV infection. Unconjugated hyperbilirubinemia develops in up to 25% of patients receiving indinavir, prompting drug discontinuation and further clinical evaluation in some ..
- Prospective validation of a novel strategy for assessing risk of significant hyperbilirubinemiaAmérico Gonçalves
Division of General Pediatrics, Pediatrics Department, Hospital Sao Joao, Porto, Portugal
Pediatrics 127:e126-31. 2011Our aim was to validate a strategy for assessing the risk of significant hyperbilirubinemia in newborns with gestational ages of ≥35 weeks by combining predischarge bilirubin percentile data with gestational age data, for a European, ..
- Hyperbilirubinemia and transcutaneous bilirubinometrySamar N El-Beshbishi
Department of Medical Parasitology, Mansoura University, Mansoura, Egypt
Clin Chem 55:1280-7. 2009Neonatal jaundice or hyperbilirubinemia is a common occurrence in newborns...
- Hyperbilirubinemia during atazanavir treatment in 2,404 patients in the Italian atazanavir expanded access program and MASTER CohortsC Torti
School of Medicine, Institute of Infectious and Tropical Diseases, University of Brescia, P le Spedali Civili, 1, 25123, Brescia, Italy
Infection 37:244-9. 2009Although the mechanism of atazanavir (ATV)-related hyperbilirubinemia is well identified, its prevalence, risk factors, and association with transaminase flares have rarely been assessed in a large population from the "real life" setting.
- Hyperbilirubinemia diminishes respiratory drive in a rat pup modelOded Mesner
Division of Neonatology, Ben Gurion University, Beer Sheva, Israel
Pediatr Res 64:270-4. 2008..the pathophysiologic basis of these episodes and their relationship to other perinatal conditions such as hyperbilirubinemia. Unconjugated hyperbilirubinemia in premature infants, even in moderately high levels, may cause ..
- In vitro analysis of the effect of hyperbilirubinemia on rabbit ureter and bladderNergis Murat
Department of Pharmacology, Dokuz Eylul University, Inciralti Izmir, Turkey
Pediatr Nephrol 21:328-32. 2006....
- Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancerTatsuharu Yamada
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
Langenbecks Arch Surg 390:421-9. 2005b>Hyperbilirubinemia is a critical complication following hepatectomy for biliary cancer. Hepatic multidrug resistance protein 2 (MRP2), a bilirubin transporter, is shown to be down-regulated by acute biliary obstruction in rats...
- Hyperbilirubinemia in appendicitis: a new predictor of perforationJoaquin J Estrada
Division of Emergency Non Trauma Surgery, Department of Surgery, Keck School of Medicine of the University of Southern California and Los Angeles County, USC Medical Center, 1200 North State Street, Los Angeles, CA 90033, USA
J Gastrointest Surg 11:714-8. 2007This study examines the relationship between hyperbilirubinemia and appendicitis. It was hypothesized that an association exists between the presence of appendiceal perforation and hyperbilirubinemia...
- The patient presenting with isolated hyperbilirubinemiaL Fabris
Department of Surgical and Gastroenterological Sciences, University of Padova, UOC Gastroenterologia, Ospedale Ca Foncello, Treviso, Padova, Italy
Dig Liver Dis 41:375-81. 2009b>Hyperbilirubinemia is a common laboratory finding in clinical practice, being found in several haematological and liver diseases as well as in familial conditions (5-10% in Western countries)...
- Single hepatic venous injection of liver-specific naked plasmid vector expressing human UGT1A1 leads to long-term correction of hyperbilirubinemia and prevention of chronic bilirubin toxicity in Gunn ratsZhen Jia
Department of Pediatrics, Waisman Center, University of Wisconsin Madison, 53705, USA
Hum Gene Ther 16:985-95. 2005..single injection of pBShUGT1A1 expressing hUGT1A1 under liver-specific regulatory control, for treatment of hyperbilirubinemia in the Gunn rat...
- Urinary tract infection and hyperbilirubinemiaHulya Bilgen
Division of Neonatology, Department of Pediatrics, Marmara University Faculty of Medicine, Istanbul, Turkey
Turk J Pediatr 48:51-5. 2006..evaluate the incidence of urinary tract infection (UTI) in newborns with asymptomatic, unexplained indirect hyperbilirubinemia in the first two weeks of life...
- Hyperbilirubinemia interferes with ADAMTS-13 activity measurement by FRETS-VWF73 assay: diagnostic relevance in patients suffering from acute thrombotic microangiopathiesS C Meyer
J Thromb Haemost 5:866-7. 2007
- Severe hyperbilirubinemia in a 10-year-old girl with a combined disorder of hereditary spherocytosis and Gilbert syndromeKenichi Sugita
Department of Pediatrics, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
Pediatr Int 49:540-2. 2007
- Hepatobiliary disease in neonatal lupus: prevalence and clinical characteristics in cases enrolled in a national registryLela A Lee
Departments of Dermatology and Medicine, University of Colorado School of Medicine, and Department of Medicine, Denver Health Medical Center, Denver, Colorado, USA
Pediatrics 109:E11. 2002..To extend the information base on the hepatobiliary manifestations of neonatal lupus erythematosus (NLE) with regard to frequency of occurrence, clinical characteristics, and outcome...
- Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphismC F Xu
GlaxoSmithKline, Research and Development, Genetics Division, New Frontiers Science Park North, Room H30 2 060, Third Avenue, Harlow, Essex CM19 5AW, UK
Br J Cancer 102:1371-7. 2010..This study examined polymorphisms in molecules involved in pharmacokinetic and pharmacodynamic pathways of pazopanib and their association with hepatic dysfunction...
- Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemiaJunko Sugatani
Department of Pharmaco Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Biochem Biophys Res Commun 292:492-7. 2002..At least one T-3263G allele was found in 21 of 25 subjects with mild hyperbilirubinemia (Gilbert's syndrome); this frequency (0...
- Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranesShojiro Kikuchi
Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Nat Genet 31:320-5. 2002..This phenotype is similar to human conjugated hyperbilirubinemia in Dubin-Johnson syndrome, which is caused by mutations in the multidrug resistance protein 2 (MRP2, gene ..
- Sickle cell disease, extreme hyperbilirubinemia, and pericardial tamponade: case report and review of the literatureImtiaz Khurshid
Department of Medicine, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
Crit Care Med 30:2363-7. 2002..We report a patient who presented with intrahepatic cholestasis, a rare and potentially lethal complication of sickle cell disease...
- Frequency of neonatal bilirubin testing and hyperbilirubinemia in a large health maintenance organizationT B Newman
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California 94143, USA
Pediatrics 104:1198-203. 1999To determine the frequency and interhospital variation of bilirubin testing and identified hyperbilirubinemia in a large health maintenance organization.
- Variations in the UDP-glucuronosyltransferase 1A1 gene for the development of unconjugated hyperbilirubinemia in TaiwaneseYang Yang Huang
Department of Laboratory Medicine, Cathay General Hospital, No 280, Section 4, Jen Ai Road, Taipei 106, Taiwan
Pharmacogenomics 9:1229-35. 2008..3279T>G in the UDP-glucuronosyltransferase (UGT)1A1 gene could be a further factor for the development of hyperbilirubinemia. However, this variant has not been reported in the Taiwanese population.
- Co-inherited Gilbert's syndrome: a factor determining hyperbilirubinemia in homozygous beta-thalassemiaR Galanello
Istituto di Clinica e Biologia dell Età Evolutiva, Universita degli Studi di Cagliari, Ospedale Regionale Microcitemie, Italy
Haematologica 84:103-5. 1999..In this paper we tested the hypothesis related to the variability of the glucuronidation bilirubin rate which depends on the configuration of the A(TA)nTAA motif of the UGT1*1 glucuronosyltransferase gene promoter...
- Amphotericin B-associated hyperbilirubinemia: case report and review of the literatureJacqueline L Olin
Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy Rutgers, State University of New Jersey, Piscataway 08854 8020, USA
Pharmacotherapy 26:1011-7. 2006A 53-year-old woman with an intraabdominal infection secondary to Candida albicans experienced hyperbilirubinemia after receiving amphotericin B in two different formulations--amphotericin B deoxycholate and amphotericin B lipid complex...
- Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemiaMargalida Rotger
Institute of Microbiology and Service of Infectious Diseases, University of Lausanne, Lausanne, Switzerland
J Infect Dis 192:1381-6. 2005Unconjugated hyperbilirubinemia results from Gilbert syndrome and from antiretroviral therapy (ART) containing protease inhibitors...
- Donor blood glucose 6-phosphate dehydrogenase deficiency reduces the efficacy of exchange transfusion in neonatal hyperbilirubinemiaSandip Samanta
Neonatal Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Pediatrics 123:e96-e100. 2009..of exchange transfusion with glucose 6-phosphate dehydrogenase-deficient blood in neonates with idiopathic hyperbilirubinemia on postexchange total serum bilirubin levels, duration of phototherapy, and need for repeat exchange ..
- Treatment of Crigler-Najjar Syndrome type 1 by hepatic progenitor cell transplantation: a simple procedure for management of hyperbilirubinemiaA A Khan
Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital and Research Center, Hyderabad, India
Transplant Proc 40:1148-50. 2008Crigler-Najjar Syndrome (CNS) is characterized by mild, chronic unconjugated hyperbilirubinemia resulting from an autosomal-recessive inherited deficiency of hepatic uridine/diphosphoglucuronate-glucuronosyl transferase 1Al since birth...
- Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1Sonia Rodriguez Novoa
Clinical Pharmacokinetic Unit, Hospital Carlos III, Madrid, Spain
Clin Infect Dis 42:291-5. 2006..Plasma levels of atazanavir were significantly higher in patients with genotype CC than in those with CT or TT, and bilirubin levels correlated with atazanavir concentrations...
- Effective oral treatment of unconjugated hyperbilirubinemia in Gunn ratsAnja M Hafkamp
Division of Pediatric Gastroenterology, Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands
Hepatology 41:526-34. 2005We sought to develop an oral treatment for unconjugated hyperbilirubinemia. In the Gunn rat model of unconjugated hyperbilirubinemia, dietary supplementation with the lipase inhibitor orlistat (Orl) or with calcium phosphate (CaP) ..
- Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vectorGabriele Toietta
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 102:3930-5. 2005Crigler-Najjar syndrome is a recessively inherited disorder characterized by severe unconjugated hyperbilirubinemia caused by a deficiency of uridine diphospho-glucuronosyl transferase 1A1...
- Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemiaSonia Rodriguez-Novoa
Pharmacokinetic and Pharmacogenetic Unit, Hospital Carlos III, Madrid, Spain
AIDS 21:41-6. 2007b>Hyperbilirubinemia is frequently seen in patients treated with atazanavir (ATV)...
- Reversible grade 4 hyperbilirubinemia in a patient with UGT1A1 7/7 genotype treated with irinotecan and cetuximabBhavna Gupta
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Clin Colorectal Cancer 6:447-9. 2007..However, severe hyperbilirubinemia (grade 3/4) has not been previously reported in association with this chemotherapeutic agent...
- UGT1A1 promoter polymorphism increases risk of nilotinib-induced hyperbilirubinemiaJ B Singer
Clinical Pharmacogenetics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
Leukemia 21:2311-5. 2007..bilirubin in humans, and a polymorphism in the promoter of the gene that encodes it has been associated with hyperbilirubinemia during treatment with a number of drugs...
- Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemiaM Kaplan
Department of Neonatology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
Proc Natl Acad Sci U S A 94:12128-32. 1997..UDPGT1), associated with benign jaundice in adults (Gilbert syndrome), increases the incidence of neonatal hyperbilirubinemia in G-6-PD deficiency...
- UGT1A1 polymorphism and hyperbilirubinemia in a patient who received sorafenibJudith Meza-Junco
Department of Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, AB T6G 1Z2, Canada
Cancer Chemother Pharmacol 65:1-4. 2009To report a single case of uridine glucuronosyltransferase 1A1 (UGT1A1) polymorphism and hyperbilirubinemia in a patient who received sorafenib.
- Seven novel mutations of the UGT1A1 gene in patients with unconjugated hyperbilirubinemiaMaria D'Apolito
Haematologica 92:133-4. 2007..to identify new pathogenic variations of the UGT1A1 gene in 11 patients diagnosed with neonatal unconjugated hyperbilirubinemia. We describe two cases in which clinically unapparent heterozygotic mutations in the UGT1A1 gene may become ..
- Effective second-line treatment with cetuximab and bevacizumab in a patient with hepatic metastases of colorectal cancer and hyperbilirubinemiaNicolas Moosmann
Medizinische Klinik III, Campus Grosshadern, Klinikum der Ludwig Maximilians Universität München, Germany
Onkologie 30:509-12. 2007..Irinotecan-based second-line chemotherapy of metastatic colorectal cancer (CRC) is effective, it might, however, be contraindicated in cases of severe liver dysfunction due to advanced liver metastases...
- A Gilbert's syndrome UGT1A1 variant confers susceptibility to tranilast-induced hyperbilirubinemiaT M Danoff
Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Philadelphia, PA, USA
Pharmacogenomics J 4:49-53. 2004..To identify the potential genetic factors that may account for the drug-induced hyperbilirubinemia, we examined polymorphisms in the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene in over a ..
- Incidence, course, and prediction of hyperbilirubinemia in near-term and term newbornsS Umit Sarici
Division of Neonatology, Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey
Pediatrics 113:775-80. 2004In this study, we investigated prospectively the incidence of significant hyperbilirubinemia and demographic and laboratory characteristics and pattern of serum bilirubin levels of near-term newborns (35-37 weeks' [245-265 days'] ..
- Involvement of UDP-glucuronosyltransferase activity in irinotecan-induced delayed-onset diarrhea in ratsMasaharu Onoue
Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi shi, Tokyo, 186 8650, Japan
Cancer Chemother Pharmacol 61:595-605. 2008..In the clinic, great care is needed when using chemotherapy with CPT-11 in patients with poor UGT activity...
- Management of hyperbilirubinemia in biliary atresia by hepatic progenitor cell transplantation through hepatic artery: a case reportA A Khan
Center for Liver Research and Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital and Research Center, Hyderabad, India
Transplant Proc 40:1153-5. 2008..As the procedure is simple and the patient has tolerated the infusion therapy, it might be repeated to manage biliary atresia...
- Prediction of hyperbilirubinaemia in the healthy term newbornX Carbonell
Hospital Clinic-Maternitat, , , IDIBAPS, Universitat de Barcelona, Spain
Acta Paediatr 90:166-70. 2001..Conclusion: There is a good correlation between TCB and TSB. In infants with TSB > or = 102 mcmol/L at 24 h or TSB > or = 154 mcmol/L or transcutaneous readings > or = 13 h at 48 h, a TSB test must be performed after 48 h of life...
- Urinary tract infections in infants: comparison between those with conjugated vs unconjugated hyperbilirubinaemiaHung Chang Lee
Department of Paediatrics, Mackay Memorial Hospital, Taiwan Department of Paediatrics, Taipei Medical Uinversity, Taiwan
Ann Trop Paediatr 25:277-82. 2005..The aim was to investigate conjugated and unconjugated hyperbilirubinaemia in association with urinary tract infection (UTI) in young infants...
- Prevention of bilirubin encephalopathyG Bertini
Department of Critical Care Medicine and Surgery, Neonatal Intensive Care Unit, Careggi University Hospital, Florence, Italy
Biol Neonate 79:219-23. 2001..of bilirubin encephalopathy is based on the detection of infants at risk of developing a significant hyperbilirubinemia. This task can be accomplished by performing a simple umbilical cord blood test, such as blood group, Rh, ..
- Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pupsMonica J Daood
Department of Pediatrics, Division of Newborn Medicine, University of Pittsburgh School of Medicine, Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
Pediatr Res 60:44-9. 2006....
- Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe JaundiceSanjiv B Amin; Fiscal Year: 2010..experienced audiologists, blinded to unbound bilirubin levels, at three different time periods: 1) time of hyperbilirubinemia 2) 2 months corrected age and 3) 9 months corrected age...
- Deriving hepatocytes from disease specific iPS to treat metabolic liver disordersNamita Roy-Chowdhury; Fiscal Year: 2013..preparation will permit sufficient repopulation of the livers of the Gunn rat model of CN1 to ameliorate hyperbilirubinemia. The specific aim 1 is (a) Generating and characterizing iPS cells from skin fibroblasts from normal ..
- Lab-on-a-chip for Neonatal Hyperbilirubinemia ScreeningVijay Srinivasan; Fiscal Year: 2012DESCRIPTION (provided by applicant): Severe hyperbilirubinemia (defined as serum bilirubin levels greater than 99th percentile) can cause a spectrum of neurologic dysfunction, of which kernicterus has the most devastating neurologic ..
- Xenobiotic sensors PXR and CAR and regulation of the UGT1 locusRobert H Tukey; Fiscal Year: 2012..these mice will be exploited to study the role of PXR and CAR towrds controlling UGT1A1 gene expression and hyperbilirubinemia. To this end, the specific aims of this competitive renewal are 1...
- Risk factors for encephalopathy in newborns with severe hyperbilirubinemiaRICHARD PARTRIDGE WENNBERG; Fiscal Year: 2010The American Academy of Pediatrics guidelines for intervention in patients with hyperbilirubinemia (total serum bilirubin concentration [TSB] modified by clinical factors) are based on sparse published clinical evidence and do not ..
- Late adverse Impact of Getting Hyperbilrubinemia or photo Therapy (LIGHT) studyThomas B Newman; Fiscal Year: 2013..The Late adverse Impact of Getting Hyperbilirubinemia or photoTherapy (LIGHT) study will fill two key knowledge gaps that prevent evidence- based treatment of ..
- Neonatal hyperbilirubinemia in a humanized UGT1 animal modelRobert H Tukey; Fiscal Year: 2013..Clinically and in selective genetic deficiencies, severe hyperbilirubinemia leads to bilurubin toxicity, which is classified as kernicterus or the depositing of bilirubin into the ..
- Point-of Care System for Determination of Bilirubin Capacity in NeonatesGLEN D RAMSAY; Fiscal Year: 2013DESCRIPTION (provided by applicant): Uncontrolled hyperbilirubinemia (jaundice) in neonates has long been known to lead to neurological dysfunction including irreversible athetoid cerebral palsy with speech, ocular and hearing ..
- Development of a Point-Of-Care Test for Determining Bilirubin in Whole BloodPETER MICHAEL GAVIN; Fiscal Year: 2011DESCRIPTION (provided by applicant): Neonatal hyperbilirubinemia (excessive bilirubin) is one of the most common problems encountered in newborns. If caught in time, hyperbilirubinemia can be treated...
- Multiplex platform for point of care newborn screening of hyperbilirubinemiaNICHOLAS TROTTA; Fiscal Year: 2013..Thus, severe neonatal hyperbilirubinemia has been nominated for inclusion on the uniform newborn screening panel in the US...
- A pilot study of moderate hyperbilirubinemia in type 1 diabetes mellitusTodd Perlstein; Fiscal Year: 2011..proposed pilot study aims to be the first step in developing a novel treatment strategy of inducing moderate hyperbilirubinemia for preventing the vascular complications of type 1 diabetes mellitus (T1DM)...
- Rochester-Buffalo Neonatal Research GroupCARL T D'ANGIO; Fiscal Year: 2013..well-designed clinical trials, with recent randomized clinical trials in the areas of neuroprotection, hyperbilirubinemia, inhaled nitric oxide, and supplemental oxygen and respiratory management...
- MATURATION OF LIVER FOR THE METABOLISM OF BILIRUBINGlenn Gourley; Fiscal Year: 1993..Such clinical circumstances result in non- conjugated hyperbilirubinemia which can be either lethal or in surviving infants produce a bilirubin encephalopathy characterized by ..
- Lab-on-a-chip for Neonatal Hyperbilirubinemia ScreeningVijay Srinivasan; Fiscal Year: 2009..health campaigning and strict guidelines for diagnosis and treatment, the estimated incidence of severe hyperbilirubinemia (defined as serum bilirubin levels greater than 99th percentile) is 1:70...
- Neonatal Phototherapy / Bilirubin ExcretionDAVID LIGHTNER; Fiscal Year: 2007..the most common clinical diagnosis in the newborn, with 60% of neonates displaying significant unconjugated hyperbilirubinemia during the first 3 days of life...
- Bilirubin and Photobilirubin: Metabolism & ExretionAntony McDonagh; Fiscal Year: 2005..The work will lead to safer more effective treatment of familial hyperbilirubinemia and jaundice in the newborn.
- GENE EXPRESIION WITH ADENOVIRUS-MEDIATED TRANSFERFrederick Askari; Fiscal Year: 2001..adenoviral liver directed gene therapy in the Gunn rat animal model of congenital non-hemolytic unconjugated hyperbilirubinemia, this proposal is linked to K08 DK02438...
- BRAIN GLUTATHIONE S-TRANSFERASES AND NEUROTOXICITYJeffrey Johnson; Fiscal Year: 2000..HPLC analysis of GSTs in jaundiced (jj) rats revealed that hyperbilirubinemia increased the concentration of Mu- class GST subunit 4 (yb2) preferentially in the flocculus and lateral ..
- Development of a Point-Of-Care Test for Determining Bilirubin in Whole BloodWAI LAW; Fiscal Year: 2009DESCRIPTION (provided by applicant): Neonatal hyperbilirubinemia (excessive bilirubin) is one of the most common problems encountered in newborns. If caught in time, hyperbilirubinemia can be treated...
- INHERITED DISORDERS OF HEPATIC BILIRUBIN GLUCORONIDATIONNamita Roy Chowdhury; Fiscal Year: 2006..Since several drugs cause hyperbilirubinemia by inhibiting UGT1A1 activity, we will delineate domains involved in binding the substrtes, UDPGA and ..
- IMMUNE RESPONSE TO ADENOVIRAL GENE TRANSFERFrederick Askari; Fiscal Year: 2000..liver directed gene therapy in the Gunn rat animal model of congenital non- hemolytic unconjugated hyperbilirubinemia. Crigler-Najjar syndrome type I, familial non-hemolytic jaundice and kernicterus, is a fatal disease which ..
- INHERITED DISORDERS OF BILIRUBIN GLUCURONIDATIONJayanta Roy Chowdhury; Fiscal Year: 1991..Inherited disorders with defective UDPGT function are associated with unconjugated hyperbilirubinemia; in severe cases (e.g...
- HYPERBILIRUBINEMIA TREATMENT WITH CLONED THERMO-ENZYMESLarry Allen; Fiscal Year: 1993..Currently, ThermoGen is communicating with established pharmaceutical companies for jointly entering into these trails...
- USE OF AN LED ARRAY FOR NEONATAL PHOTOTHERAPYDANIELLE ROSEN; Fiscal Year: 2000b>Hyperbilirubinemia (Jaundice) affects many term and most preterm infants. When infants are exposed to blue light (410 to 460 nanometers), a photochemical reaction occurs in the skin...
- MECHANISM TO LIMIT CNS BILIRUBIN INFLUX: P-GLYCOPROTEINJon Watchko; Fiscal Year: 1999DESCRIPTION (Adapted from the Applicant's Description): Unconjugated hyperbilirubinemia is the most common clinical condition in the newborn period...
- DEVELOPMENT SUBSEQUENT TO JAUNDICE OF THE NEWBORNJEAN JEW; Fiscal Year: 1980..examination of morphological and behavioral changes - including hypothesized recovery processes - after hyperbilirubinemia, are planned under controlled laboratory conditions...
- HEME AND SULFITE METABOLISM IN AMPHIBIANSAntony McDonagh; Fiscal Year: 1993..The studies may suggest new approaches for the treatment of familial unconjugated hyperbilirubinemia and the prevention of jaundice in newborn babies.
- Multiple Mechanisms of Hepatoprotective Mrp3 InductionNathan Cherrington; Fiscal Year: 2005..Additionally, other outcomes of cholestasis include an increase in oxidative stress, hyperbilirubinemia, inflammation and cytokine releasc, all of which, individually, effect the regulation of xenobiotic ..
- MANAGEMENT OF HYPERBILIRUBINEMIA IN NEWBORNSAttallah Kappas; Fiscal Year: 2000This project is a follow-on to a clinical trial for the "Management of Hyperbilirubinemia in the Newborn"...
- A Fluorescent Assay for Free Unconjugated BilirubinJ Kampf; Fiscal Year: 2005Current diagnostic tests for severe neonatal hyperbilirubinemia do not correlate well with bilirubinencephalopathy in newboms, contributing to uncertainty in the management of jaundiced infants...
- RAPID DETECTION OF PRE-AND NEONATAL METABOLIC DISORDERSEUGENE WATSON; Fiscal Year: 2001..of bilirubin, a metabolite which is an indicator for a variety of metabolic disorders, including hyperbilirubinemia in infants...
- NEONATAL BILIRUBIN NEUROTOXICITY AND P-GLYCOPROTEINJon Watchko; Fiscal Year: 2007..CNS parenchyma as well as cells of the BBB in humans; and 3) CNS Pgp expression is upregulated by postnatal hyperbilirubinemia and antenatal maternal vitamin A treatment in Gunn rat pups, and that combined antenatal vitamin A treatment ..
- Bilirubin-induced Auditory Neuropathy in PretermsSANJIV AMIN; Fiscal Year: 2008..incidence and determinants of bilirubin-induced auditory neuropathy (AN) in high-risk premature infants with hyperbilirubinemia. AN was first reported in 1996...
- REGULATION OF HEME OXYGENASE IN NEONATAL ANIMALSDavid Stevenson; Fiscal Year: 2005..abstract_text> ..
- Chromium Mesoporphyrin in the Prevention of Neonatal JaundiceDavid K Stevenson; Fiscal Year: 2010..b>Hyperbilirubinemia is exacerbated by hemolytic diseases, such as Rhesus isoimmunization and ABO incompatibility, which result ..
- Effects of Statins on Heme Oxygenase-1 RegulationDavid Stevenson; Fiscal Year: 2008..to delineate the role of HO-1 as a novel therapeutic target for statins and mediator of protective effects under conditions of insuffi- cient HO-1 expression such as pre-eclampsia and other pregnancy-related disorders ..
- Therapeutic Use of Heme Analogs: Absorption in IntestineDavid Stevenson; Fiscal Year: 2009Neonatal jaundice occurs in 60-70% of all newborn infants. It is due to hyperbilirubinemia caused not only by an overproduction of bilirubin, but also by a transient failure to excrete this metabolite...
- BILIRUBIN TOXICITY IN THE AUDITORY SYSTEMSteven Shapiro; Fiscal Year: 2005..dysfunction continue to be major complications of bilirubin toxicity despite advances in the treatment of hyperbilirubinemia (jaundice) in newborns...
- Improving Survival For Small-For-Size Liver GraftsZhi Zhong; Fiscal Year: 2004..This work will develop mechanism-based strategies to increase the use and improve the outcome of partial livers for transplantation in the clinic. ..
- Mechanisms of In Vivo Ethanol-Induced Mitochondrial DepolarizationZhi Zhong; Fiscal Year: 2010....
- Transplantation of Reduced-Size Fatty LiversZhi Zhong; Fiscal Year: 2010....
- Prediciting Severe Neonatal HyperbilirubinemiaRon Keren; Fiscal Year: 2007..newborn screening and disease prevention in general, and to the prediction and prevention of severe neonatal hyperbilirubinemia and kernicterus in particular. The specific aims of the research application are three-fold...
- Dystonia in an Animal Model of KernicterusSteven Shapiro; Fiscal Year: 2007..disorders continue to be major complications of bilirubin toxicity despite advances in the treatment of hyperbilirubinemia (jaundice) in newborns...
- MATERNAL ALCOHOL IMPAIRS FETAL ALVEOLAR MACROPHAGETHERESA GAUTHIER; Fiscal Year: 2002..Understanding the modulatory role of GSH availability in AM function will broaden our understanding of GSH supplements not only as a possible therapy for infants exposed to ETOH in utero but premature infants in general. ..
- BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTESEllen Ebert; Fiscal Year: 2002..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
- Heparan Sulfate Proteoglycans and HIV PathogenesisPhilippe Gallay; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- GESTATIONAL DIABETES: DIAGNOSTIC CRITERIA AND OUTCOMESAssiamira Ferrara; Fiscal Year: 2003..are associated with increased risk of selected perinatal complications: infant severe macrosomia, severe hyperbilirubinemia, hypoglycemia, respiratory distress syndrome, and maternal preeclampsia/eclampsia...
- Cerebral Hemorrhage Model: Mechanisms and TreatmentsKenneth Wagner; Fiscal Year: 2005..abstract_text> ..
- GLUCURONIDATION OF DIETARY AND ENVIRONMENTAL CARCINOGENSRobert Tukey; Fiscal Year: 2002....
- Molecular Biology of Erythrocyte AnkyrinPatrick G Gallagher; Fiscal Year: 2010..These studies may provide important information to be used for diagnosis and treatment of patients with this disorder. ..
- Comparative effectiveness of diabetes prevention strategies in women with GDMAssiamira Ferrara; Fiscal Year: 2010..Finding that this intervention is cost-effective in this setting should motivate its adoption at KP as well as in other health care systems. ..
- Role of Cytokines and Autoimmunity in Murine BACara Mack; Fiscal Year: 2005..Defining the immunopathology in biliary atresia will lead to a better understanding of the etiopathogenesis and provide insight into future therapeutic options. ..
- Prenatal Exposure to Polyfluoroalkyl Compounds in the EMA StudyLisa A Croen; Fiscal Year: 2010..In the long-term, a better understanding of the underlying biology may suggest appropriate strategies for early intervention and contribute to the eventual prevention of this often devastating and usually life-long disability. ..
- Iron Therapy in Renal Disease: Potential ToxicitiesRICHARD ZAGER; Fiscal Year: 2008..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
- Rare Liver Disease NetworkRonald Sokol; Fiscal Year: 2005..The RLDN will be a full partner in the Rare Diseases Clinical Research Network and will participate collaboratively with the other Clinical Research Centers and the Data and Technology Coordinating Center. ..
- c-Kit Activating Mutations and Drug Resistance in AMLRobert Arceci; Fiscal Year: 2005..These data may also be useful for stratification of patients according to cytokine receptor mutations and subsequent treatment with non-genotoxic therapies that target specific biological pathways. ..
- Biliary Microlithiasis in Alcohol Induced PancreatitisArun Sanyal; Fiscal Year: 2007..The long-term goal is to use data from this R21 proposal to develop a RO1 proposal about a large scale phase III clinical trial of UDCA for alcohol-induced pancreatitis. [unreadable] [unreadable] [unreadable]..