hyperinsulinism

Summary

Summary: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.

Top Publications

  1. ncbi Clinical features of 52 neonates with hyperinsulinism
    P de Lonlay-Debeney
    Department of Pediatrics, Hopital des Enfants Malades, Paris, France
    N Engl J Med 340:1169-75. 1999
  2. ncbi The biochemical assessment of insulin resistance
    Anwar Borai
    Centre for Clinical Science and Measurement, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UK
    Ann Clin Biochem 44:324-42. 2007
  3. pmc Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, NY 10461, USA
    J Natl Cancer Inst 101:48-60. 2009
  4. pmc Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes
    Ruslan Novosyadlyy
    Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 70:741-51. 2010
  5. ncbi Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse
    Julio E Ayala
    Vanderbilt NIDDK National Institutes of Diabetes and Digestive and Kidney Diseases Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Diabetes 55:390-7. 2006
  6. ncbi Neurological aspects of hyperinsulinism-hyperammonaemia syndrome
    Nadia Bahi-Buisson
    Department of Paediatric Neurology and Metabolic Diseases, Necker Children s Hospital, Paris V University, Paris, France
    Dev Med Child Neurol 50:945-9. 2008
  7. pmc Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle
    Eun Gyoung Hong
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Diabetes 58:2525-35. 2009
  8. ncbi Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies
    Paola Pisani
    Cancer Epidemiology Unit, Richard Doll Building, The Oxford University, Old Road Campus, Roosevelt Drive, Headington, Oxford
    Arch Physiol Biochem 114:63-70. 2008
  9. ncbi Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life
    G Dorner
    Bereich Charité der Humboldt Universität, Institut für Experimentelle Endokrinologie, Berlin, Germany
    Horm Metab Res 26:213-21. 1994
  10. ncbi Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabetes Care 23:57-63. 2000

Detail Information

Publications344 found, 100 shown here

  1. ncbi Clinical features of 52 neonates with hyperinsulinism
    P de Lonlay-Debeney
    Department of Pediatrics, Hopital des Enfants Malades, Paris, France
    N Engl J Med 340:1169-75. 1999
    ..Neonatal hyperinsulinemic hypoglycemia is often resistant to medical therapy and is often treated with near-total pancreatectomy. However, the pancreatic lesions may be focal and treatable by partial pancreatic resection...
  2. ncbi The biochemical assessment of insulin resistance
    Anwar Borai
    Centre for Clinical Science and Measurement, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UK
    Ann Clin Biochem 44:324-42. 2007
    ..Insulin resistance is increasingly being assessed in clinical situations, where relatively simple markers are required. Insulin-like growth factor binding protein-1 is an emerging marker which may be useful in this context...
  3. pmc Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, NY 10461, USA
    J Natl Cancer Inst 101:48-60. 2009
    ..However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of estrogen level...
  4. pmc Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes
    Ruslan Novosyadlyy
    Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 70:741-51. 2010
    ..Our findings offer compelling experimental evidence that T2D accelerates mammary gland development and carcinogenesis,and that the IR and/or the IGF-IR are major mediators of these effects...
  5. ncbi Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse
    Julio E Ayala
    Vanderbilt NIDDK National Institutes of Diabetes and Digestive and Kidney Diseases Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Diabetes 55:390-7. 2006
    ..kg(-1) . min(-1)), but endoR(a) was fully suppressed with doses higher than 0.8 mU . kg(-1) . min(-1). Thus, common variations in experimental factors yield different results and should be considered in designing and interpreting clamps...
  6. ncbi Neurological aspects of hyperinsulinism-hyperammonaemia syndrome
    Nadia Bahi-Buisson
    Department of Paediatric Neurology and Metabolic Diseases, Necker Children s Hospital, Paris V University, Paris, France
    Dev Med Child Neurol 50:945-9. 2008
    b>Hyperinsulinism-hyperammonaemia syndrome (HHS) is a rare cause of congenital hyperinsulinism, due to missense mutations in the GLUD1 gene, resulting in glutamate dehydrogenase (GDH) overactivity...
  7. pmc Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle
    Eun Gyoung Hong
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Diabetes 58:2525-35. 2009
    ..We examined the role of IL-10 in glucose homeostasis using transgenic mice with muscle-specific overexpression of IL-10 (MCK-IL10)...
  8. ncbi Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies
    Paola Pisani
    Cancer Epidemiology Unit, Richard Doll Building, The Oxford University, Old Road Campus, Roosevelt Drive, Headington, Oxford
    Arch Physiol Biochem 114:63-70. 2008
    ..The hypothesis that high circulating levels of insulin could be the underlying factor increasing cancer risk has been proposed. Epidemiological studies on markers of hyper-insulinaemia and cancer are reviewed and summarized...
  9. ncbi Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life
    G Dorner
    Bereich Charité der Humboldt Universität, Institut für Experimentelle Endokrinologie, Berlin, Germany
    Horm Metab Res 26:213-21. 1994
    ..In this context, fetal and/or neonatal hyperinsulinism occurring during a critical period of brain development and leading to permanent malorganization of ..
  10. ncbi Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    E Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
    Diabetes Care 23:57-63. 2000
    ..To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans...
  11. ncbi Adenosine diphosphate as an intracellular regulator of insulin secretion
    C G Nichols
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Science 272:1785-7. 1996
    ..Thus, by binding to SUR NBF2 and antagonizing ATP inhibition of KATP++ channels, intracellular MgADP may regulate insulin secretion...
  12. ncbi Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism
    Olga T Hardy
    Division of Endocrinology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 92:4706-11. 2007
    Focal lesions in infants with congenital hyperinsulinism (HI) represent areas of adenomatosis that express a paternally derived ATP-sensitive potassium channel mutation due to embryonic loss of heterozygosity for the maternal 11p region...
  13. ncbi Familial hyperinsulinism caused by an activating glucokinase mutation
    B Glaser
    Department of Endocrinology and Metabolism, Hebrew University Hadassah Medical School, Jerusalem, Israel
    N Engl J Med 338:226-30. 1998
  14. ncbi Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
    P M Thomas
    Department of Medical Specialties, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Science 268:426-9. 1995
    ..Both mutations resulted in aberrant processing of the RNA sequence and disruption of the putative second nucleotide binding domain of the SUR protein. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene...
  15. pmc Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression
    Yvonne Fierz
    Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Diabetes 59:686-93. 2010
    ..Thus, we hypothesized that pharmacological reduction of elevated insulin levels would attenuate type 2 diabetes-mediated mammary tumor progression...
  16. ncbi Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation
    Antonio L Cuesta-Muñoz
    Hospital Carlos Haya Foundation and Department of Endocrinology, Diabetes and Nutrition of Carlos Haya University Hospital, Malaga, Spain
    Diabetes 53:2164-8. 2004
    ..These findings demonstrate that the range of the clinical phenotype caused by GCK mutations varies from complete insulin deficiency to extreme hyperinsulinemia...
  17. pmc Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation
    Anita M van den Hoek
    TNO Quality of Life, Gaubius Laboratory, Leiden, The Netherlands
    Diabetes 57:2304-10. 2008
    ..Therefore, the aim of this study was to establish whether intracerebroventricular NPY administration modulates the suppressive action of insulin on EGP via hepatic sympathetic or parasympathetic innervation...
  18. ncbi Insulin resistance and secretion in vivo: effects of different antipsychotics in an animal model
    Araba F Chintoh
    Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Schizophr Res 108:127-33. 2009
    ..Our data also support the preclinical use of these clamp procedures in screening putative antipsychotics...
  19. ncbi Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery
    Geoffrey J Service
    Department of Surgery, Mayo Clinic and Foundation, Rochester, MN, USA
    N Engl J Med 353:249-54. 2005
    ..Hypoglycemic symptoms diminished postoperatively. We speculate that hyperfunction of pancreatic islets did not lead to obesity but that beta-cell trophic factors may have increased as a result of gastric bypass...
  20. pmc Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management
    Karen J Loechner
    Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, USA
    Diabetes 60:209-17. 2011
    ..Gain- or loss-of-function mutations in channel subunits underlie human neonatal diabetes and congenital hyperinsulinism (HI), respectively...
  21. pmc An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism
    Ning Shen
    Ministry of Education Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and the Medical School of Nanjing University, Nanjing 210061, China
    J Biol Chem 286:14508-15. 2011
    ..characteristics of type 2 diabetes is insulin resistance, during which the patients normally experienced hyperinsulinism stress that would alter insulin signal transduction in insulin target tissues...
  22. ncbi The cellular and molecular mechanisms by which insulin influences breast cancer risk and progression
    David P Rose
    Department of Surgery, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, 26506, USA
    Endocr Relat Cancer 19:R225-41. 2012
    ..Understanding the various mechanisms by which insulin participates in breast cancer cell biology provides opportunities for novel approaches to treatment...
  23. pmc Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate
    Jose E Galgani
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 57:841-5. 2008
    ....
  24. pmc Paternal mutation of the sulfonylurea receptor (SUR1) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia
    V Verkarre
    INSERM UR 383, Hopital Necker Enfants Malades, University Paris V, 75743 Paris Cedex 15, France
    J Clin Invest 102:1286-91. 1998
    Congenital hyperinsulinism, or persistent hyperinsulinemic hypoglycemia of infancy (PHHI), is a glucose metabolism disorder characterized by unregulated secretion of insulin and profound hypoglycemia...
  25. pmc Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor
    Eva Gonzalez
    Biochemistry Department, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:10162-7. 2011
    ..Identification of uncoupled insulin action in adipocytes suggests this condition might be a general phenomenon of insulin target tissues contributing to insulin resistance's pathophysiology...
  26. ncbi Long-term follow-up of 114 patients with congenital hyperinsulinism
    Thomas Meissner
    Clinic of General Pediatrics, University Children s Hospital, Dusseldorf, Germany
    Eur J Endocrinol 149:43-51. 2003
    The term congenital hyperinsulinism (CHI) comprises a group of different genetic disorders with the common finding of recurrent episodes of hyperinsulinemic hypoglycemia.
  27. pmc Deletion of cd39/entpd1 results in hepatic insulin resistance
    Keiichi Enjyoji
    Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:2311-20. 2008
    ..CD39/ENTPD1 is the dominant vascular and immune cell ectoenzyme that hydrolyzes extracellular nucleotides to regulate purinergic signaling...
  28. ncbi Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene
    C A Stanley
    Division of Endocrinology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
    N Engl J Med 338:1352-7. 1998
    A new form of congenital hyperinsulinism characterized by hypoglycemia and hyperammonemia was described recently...
  29. ncbi Congenital disorder of glycosylation id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasia
    Liangwu Sun
    The Burnham Institute, Program for Glycobiology and Carbohydrate Chemistry, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Clin Endocrinol Metab 90:4371-5. 2005
    ..Inborn errors in protein glycosylation, such as the congenital disorders of glycosylation (CDGs), generate multifaceted syndromes that impair many organ systems. We here report the diagnosis of the third known patient with CDG-Id...
  30. ncbi Trajectories of growth among children who have coronary events as adults
    David J P Barker
    Developmental Origins of Health and Disease Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    N Engl J Med 353:1802-9. 2005
    ..Low birth weight is a risk factor for coronary heart disease. It is uncertain how postnatal growth affects disease risk...
  31. pmc Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations
    S E Flanagan
    Peninsula Medical School, Institute of Biomedical and Clinical Science, University of Exeter, Exeter, UK
    Eur J Endocrinol 162:987-92. 2010
    ..In this study, we investigated the prevalence of HNF4A mutations in a large cohort of patients with diazoxide responsive hyperinsulinemic hypoglycemia (HH)...
  32. ncbi CEACAM1 regulates insulin clearance in liver
    Matthew N Poy
    Department of Pharmacology, 3035 Arlington Avenue, HSci Building Room 270, Toledo, Ohio 43614, USA
    Nat Genet 30:270-6. 2002
    ..These findings suggest a mechanism through which insulin signaling regulates insulin sensitivity by modulating hepatic insulin clearance...
  33. pmc The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet
    James S McTaggart
    Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, and OXION Centre for Ion Channel Studies, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    J Physiol 588:3201-9. 2010
    ..This symposium review focuses on our current understanding of the role of the K(ATP) channel in glucose homeostasis in health and disease...
  34. ncbi Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer
    Jan Hammarsten
    Department of Urology, Central Hospital, SE 30185 Halmstad, Sweden
    Eur J Cancer 41:2887-95. 2005
    ..Furthermore, our data suggest that the insulin level could be used as a marker of prostate cancer prognosis and tumour aggressiveness, regardless of the patient's prostate cancer stage, cancer grade and PSA level...
  35. ncbi Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand
    Vijender R Vaidyula
    Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Diabetes 55:202-8. 2006
    ....
  36. ncbi Obesity related hyperinsulinaemia and hyperglycaemia and cancer development
    Susen Becker
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Arch Physiol Biochem 115:86-96. 2009
    ....
  37. pmc Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 106:12121-6. 2009
    ..Thus, in contrast to current dogma, these data demonstrate that increased transcriptional expression of PEPCK1 and G6Pc does not account for increased gluconeogenesis and fasting hyperglycemia in patients with T2DM...
  38. pmc Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    Katsutaro Morino
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
    J Clin Invest 115:3587-93. 2005
    ....
  39. pmc Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion
    P T Clayton
    London Centre for Paediatric Endocrinology and Metabolism, Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College London, United Kingdom
    J Clin Invest 108:457-65. 2001
    ..However, unlike other children with hyperinsulinism, this patient had a persistently elevated blood spot hydroxybutyrylcarnitine concentration when fed, as well ..
  40. ncbi Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    G Perseghin
    Division of Internal Medicine, Istituto Scientifico H San Raffaele, Milan, Italy
    Diabetes 48:1600-6. 1999
    ....
  41. ncbi Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    A Christine Könner
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Center for Molecular Medicine, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 5:438-49. 2007
    ..However, insulin action specifically in AgRP-expressing neurons does play a critical role in controlling hepatic glucose production and may provide a target for the treatment of insulin resistance in type 2 diabetes...
  42. ncbi Hypothalamic K(ATP) channels control hepatic glucose production
    Alessandro Pocai
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 434:1026-31. 2005
    ..These findings suggest that activation of hypothalamic K(ATP) channels normally restrains hepatic gluconeogenesis, and that any alteration within this central nervous system/liver circuit can contribute to diabetic hyperglycaemia...
  43. ncbi Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism/hyperammonemia syndrome
    B Y Hsu
    Division of Endocrinology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr 138:383-9. 2001
    OBJECTIVE: Because the hyperinsulinism/hyperammonemia (HI/HA) syndrome is associated with gain of function mutations in the leucine-stimulated insulin secretion pathway, we examined whether protein feeding or fasting was responsible for ..
  44. ncbi Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: relation to reduced fetal growth
    L Ibanez
    Adolescent and Endocrine Unit, Hospital Universitari Materno Infantil Vall d Hebron, Barcelona, Spain
    J Clin Endocrinol Metab 83:3558-62. 1998
    Pronounced adrenarche with precocious pubarche (PP) in girls has been associated with hyperinsulinism and subsequent functional ovarian hyperandrogenism (FOH)...
  45. pmc The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study
    Otto Tschritter
    Medizinische Klinik der Universität, University of Tubingen, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 103:12103-8. 2006
    ..Moreover, cerebrocortical insulin resistance is found in individuals with the Gly972Arg polymorphism in IRS-1, which is considered a type 2 diabetes risk gene...
  46. ncbi Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism
    Francis M Hoe
    Divisions of Endocrinology and Neonatology, Department of Pediatrics, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Pediatr 148:207-12. 2006
    To characterize the clinical features and insulin regulation in infants with hypoglycemia due to prolonged neonatal hyperinsulinism.
  47. ncbi Congenital hyperinsulinism: pancreatic [18F]fluoro-L-dihydroxyphenylalanine (DOPA) positron emission tomography and immunohistochemistry study of DOPA decarboxylase and insulin secretion
    Pascale de Lonlay
    Departement de Pediatrie, Hopital Necker Enfants Malades, Universite Paris Descartes, Faculte de Medecine, 149 rue de Sevres, 75743 Paris Cedex 15, France
    J Clin Endocrinol Metab 91:933-40. 2006
    Congenital hyperinsulinism (HI) is characterized by hypoglycemia related to inappropriate insulin secretion. Focal and diffuse forms of hyperinsulinism share a similar clinical presentation, but their treatment is dramatically different...
  48. ncbi Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:1528-34. 2003
    ....
  49. pmc Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins
    Alexandre Charbonneau
    Axe Cardiologie, Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
    Diabetes 59:861-71. 2010
    ..The present study was undertaken to assess the contribution of inducible nitric oxide (NO) synthase (iNOS) to lipid-induced insulin resistance in vivo...
  50. ncbi Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases
    Pascale de Lonlay
    fédération de pédiatrie, Hopital Necker Enfants Malades, Paris, France
    Eur J Pediatr 161:37-48. 2002
    b>Hyperinsulinism is a heterogeneous disorder characterised by severe hypoglycaemia due to an inappropriate oversecretion of insulin...
  51. ncbi C-reactive protein is independently associated with fasting insulin in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, Mass 02215 1204, USA
    Arterioscler Thromb Vasc Biol 23:650-5. 2003
    ..Insulin resistance is associated with chronic subclinical inflammation, and both conditions are linked with increased risk for type 2 diabetes mellitus and atherothrombotic cardiovascular disease...
  52. ncbi Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations
    Ritika R Kapoor
    London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, and the Institute of Child Health, University College London, London, UK
    Diabetes 57:1659-63. 2008
    ..Recently, heterozygous mutations in the HNF4A gene were reported to cause transient hyperinsulinemic hypoglycemia associated with macrosomia...
  53. ncbi Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects
    Kristin R Freeland
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Br J Nutr 103:82-90. 2010
    ..Since GLP-1 may increase insulin sensitivity and secretion, these results may provide a mechanism for the epidemiological association between high cereal fibre intake and reduced risk for diabetes...
  54. ncbi Systemic and regional free fatty acid metabolism in type 2 diabetes
    A Basu
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Endocrinol Metab 280:E1000-6. 2001
    ..45, P < 0.03) during both insulin infusions. We conclude that type 2 diabetes is associated with a generalized impairment in insulin suppression of lipolysis compared with equally obese ND individuals...
  55. ncbi Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells
    Lei Zhou
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, People s Republic of China
    J Nat Med 65:50-6. 2011
    ..In the current study, we tested the hypothesis that Ginkgo biloba extract (GBE) prevented hyperinsulinism-induced glucose intolerance in hepatocytes...
  56. pmc Next-generation sequencing reveals deep intronic cryptic ABCC8 and HADH splicing founder mutations causing hyperinsulinism by pseudoexon activation
    Sarah E Flanagan
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter EX2 5DW, UK
    Am J Hum Genet 92:131-6. 2013
    ..showed that these are founder mutations in the Irish and Turkish populations, accounting for 14% of focal hyperinsulinism cases and 32% of subjects with HADH mutations in our cohort...
  57. pmc A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans
    Thomas Pj Solomon
    Department of Pathobiology, Lerner Research Institute and Nutrition, Case Western Reserve University, Cleveland, OH, USA
    Am J Clin Nutr 92:1359-68. 2010
    ..The optimal lifestyle intervention that reverses diabetes risk factors is not known...
  58. ncbi A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia
    C Weyer
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 49:2094-101. 2000
    ..Whether amelioration of basal insulin hypersecretion will prevent diabetes remains to be elucidated...
  59. ncbi Insulin signaling in human skeletal muscle: time course and effect of exercise
    J F Wojtaszewski
    Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
    Diabetes 46:1775-81. 1997
    ..Thus, the activity of IRS-1-associated PI 3-kinase and glucose uptake may not always be tightly coupled during insulin stimulation in human muscle...
  60. pmc Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
    Christopher J Ramnanan
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Clin Invest 121:3713-23. 2011
    ..In the context of basal insulin and glucagon levels at the liver, this input augments hepatic glucose uptake and glycogen synthesis, reducing NHGO without altering EGP...
  61. pmc Hyperinsulinaemic hypoglycaemia: biochemical basis and the importance of maintaining normoglycaemia during management
    Khalid Hussain
    London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Arch Dis Child 92:568-70. 2007
  62. ncbi Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance
    Istvan Kurucz
    Department of Cellular Biology, BIOREX Research and Development, Veszprem, Hungary
    Diabetes 51:1102-9. 2002
    ....
  63. pmc Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees
    Sarah E Flanagan
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter, EX2 5DW, United Kingdom
    J Clin Endocrinol Metab 96:E498-502. 2011
    ....
  64. pmc Prolonged hyperinsulinaemic hypoglycaemia in newborns with intrauterine growth retardation
    O Fafoula
    Arch Dis Child Fetal Neonatal Ed 91:F467. 2006
  65. pmc Transient hyperinsulinism associated with macrosomia, hypertrophic obstructive cardiomyopathy, hepatomegaly, and nephromegaly
    A Mehta
    Great Ormond Street Hospital and The Institute of Child Health, London, UK
    Arch Dis Child 88:822-4. 2003
  66. ncbi Type 2 diabetes mellitus and risk of malignancy: is there a strategy to identify a subphenotype of patients with increased susceptibility to endogenous and exogenous hyperinsulinism?
    K Müssig
    Department of Internal Medicine, Eberhard Karls University, Member of the German Center for Diabetes Research, Tubingen, Germany
    Diabet Med 28:276-86. 2011
    ..To give an overview on the relationship between diabetes mellitus and increased cancer risk...
  67. ncbi Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD gene
    Khalid Hussain
    London Centre for Paediatric Endocrinology and Metabolism, Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College and Great Ormond Street Hospital for Children NHS Trust, 30 Guilford Street, London WC1N 1EH, UK
    J Pediatr 146:706-8. 2005
    ..a novel splice site mutation in the short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) gene associated with hyperinsulinism. This mutation resulted in a nearly complete absence of immunoreactive protein and a decrease in fibroblast ..
  68. pmc Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
    A M Fernandez
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 15:1926-34. 2001
    ..Pancreatic beta-cell dysfunction developed at a relative early age, resulting in diabetes. These mice provide an excellent model to study the molecular mechanisms underlying the development of human type 2 diabetes...
  69. ncbi Genetic heterogeneity in familial hyperinsulinism
    A Nestorowicz
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 7:1119-28. 1998
    Familial hyperinsulinism (HI) is a disorder characterized by dysregulation of insulin secretion and profound hypoglycemia. Mutations in both the Kir6...
  70. pmc Basal-state hyperinsulinemia in healthy normoglycemic adults is predictive of type 2 diabetes over a 24-year follow-up: a preliminary report
    Rachel Dankner
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
    Diabetes Care 32:1464-6. 2009
    ..CONCLUSIONS Basal hyperinsulinemia in normoglycemic adults constitutes an independent risk factor for developing dysglycemia over 24 years...
  71. pmc Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
    Abigail May Khan
    Cardiology Division, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3242-9. 2011
    ..It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown...
  72. ncbi A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene
    Kurt Højlund
    Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Kloevervaenget 6, DK 5000, Odense C, Denmark
    Diabetes 53:1592-8. 2004
    ....
  73. ncbi Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis
    Helen G Mulholland
    Cancer Epidemiology and Prevention Research Group, Centre for Clinical and Population Sciences, Queen s University Belfast, Mulhouse Building, Royal Victoria Hospital Site, Belfast, Northern Ireland
    Am J Clin Nutr 89:568-76. 2009
    ..Habitual consumption of diets with a high glycemic index (GI) and a high glycemic load (GL) may influence cancer risk via hyperinsulinemia and the insulin-like growth factor axis...
  74. ncbi Insulin gene variable number of tandem repeat genotype and the low birth weight, precocious pubarche, and hyperinsulinism sequence
    L Ibanez
    Endocrine Unit, Hospital Sant Joan de Deu, University of Barcelona L I, 08950 Barcelona, Spain
    J Clin Endocrinol Metab 86:5788-93. 2001
    ..A similar interaction between genotype and intrauterine growth restraint may underlie other reported links between low birth weight and adulthood disease risks...
  75. ncbi Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia
    F Menni
    , , Centre Hospitalier Universitaire Necker-Enfants Malades, Paris, France
    Pediatrics 107:476-9. 2001
    ..8 were treated medically and 46 were operated on (19 for a focal adenomatous hyperplasia and 27 for diffuse hyperinsulinism)...
  76. ncbi Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome
    Jason R Treberg
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Am J Physiol Endocrinol Metab 298:E1219-25. 2010
    ..These results are discussed in relation to the organ source of the ammonia in the HI/HA syndrome as well as the role of GDH in regulating renal ammoniagenesis...
  77. pmc Exercise induced hypoglycaemic hyperinsulinism
    T Meissner
    Division of Metabolic and Endocrine Diseases, University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany
    Arch Dis Child 84:254-7. 2001
    BACKGROUND: Hyperinsulinism in childhood is often caused by genetic defects involving the regulation of insulin secretion leading to recurrent episodes of hypoglycaemia. We report two patients with exercise induced hypoglycaemia...
  78. ncbi Insulin, C-peptide and proinsulin for the biochemical diagnosis of hypoglycaemia related to endogenous hyperinsulinism
    D Vezzosi
    Department of Endocrinology, Centre Hospitalier Universitaire Rangueil, 1 avenue Jean Poulhes, TSA 50032, 31059 Toulouse Cedex 9, France
    Eur J Endocrinol 157:75-83. 2007
    We evaluated the respective value of insulin, C-peptide and proinsulin levels in 33 patients with endogenous hyperinsulinism and in 67 controls to determine the best parameters and thresholds to make or to rule out the diagnosis of ..
  79. ncbi Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism
    Sarah E Flanagan
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, United Kingdom
    Hum Mutat 30:170-80. 2009
    ..2, and ABCC8, which encodes for SUR1, can cause oversecretion of insulin and result in hyperinsulinism of infancy, while activating mutations in KCNJ11 and ABCC8 have recently been described that result in the ..
  80. ncbi p57(KIP2) expression in normal islet cells and in hyperinsulinism of infancy
    S A Kassem
    Department of Endocrinology and Metabolism, Hebrew University, Hadassah Medical Center, Jerusalem, Israel
    Diabetes 50:2763-9. 2001
    Most cases of hyperinsulinism of infancy (HI) are caused by mutations in either the sulfonylurea receptor-1 (SUR1) or the inward rectifying K(+) channel Kir6.2, two subunits of the beta-cell ATP-sensitive K(+) channel (K(ATP) channel)...
  81. pmc Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations
    Samir Sayed
    Clinical Translational Research Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:1419-27. 2009
    Heterozygous activating mutations of glucokinase have been reported to cause hypoglycemia attributable to hyperinsulinism in a limited number of families...
  82. ncbi Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release
    Timo Otonkoski
    Program for Developmental and Reproductive Biology, Biomedicum, Helsinki, Finland
    Diabetes 52:199-204. 2003
    ..strenuous physical exercise leads to hypoglycemia caused by inappropriate insulin release (exercise-induced hyperinsulinism [EIHI])...
  83. ncbi Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans
    Mattias Soop
    North West Injury Research Collaboration, Hope Hospital, Salford, M6 8HD, United Kingdom
    Am J Physiol Endocrinol Metab 282:E1276-85. 2002
    ..Hyperinsulinemia indirectly enhances key components of the systemic inflammatory and stress responses in this human model of infection...
  84. ncbi Hyperinsulinism in infancy and childhood: when an insulin level is not always enough
    Andrew A Palladino
    The Children s Hospital of Philadelphia, Division of Endocrinology, Philadelphia, PA, USA
    Clin Chem 54:256-63. 2008
    Hypoglycemia in infants and children can lead to seizures, developmental delay, and permanent brain damage. Hyperinsulinism (HI) is the most common cause of both transient and permanent disorders of hypoglycemia...
  85. pmc Central nervous system delivery of the antipsychotic olanzapine induces hepatic insulin resistance
    Paulo J F Martins
    Obesity Research Center, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 59:2418-25. 2010
    ..Recent evidence shows that OLZ alters insulin sensitivity independent of changes in body weight and composition. The present study addresses whether OLZ-induced insulin resistance is driven by its central actions...
  86. pmc Hyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations
    Ritika R Kapoor
    Developmental Endocrinology Research Group, Molecular Genetics Unit, London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, and the Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Eur J Endocrinol 161:731-5. 2009
    ..in the GLUD1 gene (which encodes for the intra-mitochondrial enzyme glutamate dehydrogenase, GDH) cause the hyperinsulinism-hyperammonaemia (HI/HA) syndrome. Patients present with HA and leucine-sensitive hypoglycaemia...
  87. ncbi Insulin causes endothelial dysfunction in humans: sites and mechanisms
    Guido Arcaro
    Division of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona Medical School and Azienda Ospedaliera di Verona, Verona, Italy
    Circulation 105:576-82. 2002
    ..Endothelium plays a central role in atherogenesis. The in vivo effects of hyperinsulinemia on endothelial function of large conduit arteries are unknown...
  88. pmc Associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among U.S. adults without physician-diagnosed diabetes: NHANES, 2003-2006
    Guixiang Zhao
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 33:344-7. 2010
    ..To examine whether concentrations of serum 25-hydroxyvitamin D (25[OH]D) and parathyroid hormone (PTH) are associated with surrogate markers of insulin resistance (IR) in U.S. adults without physician-diagnosed diabetes...
  89. pmc Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes
    J C Devedjian
    Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    J Clin Invest 105:731-40. 2000
    ..These results indicate that local overexpression of IGF-II in islets might lead to type 2 diabetes and that islet hyperplasia and hypersecretion of insulin might occur early in the pathogenesis of this disease...
  90. pmc Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance
    Clinton R Bruce
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:550-8. 2009
    ....
  91. ncbi Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    I Sadaf Farooqi
    University Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 348:1085-95. 2003
    ..However, the clinical spectrum and mode of inheritance have not been defined, pathophysiological mechanisms leading to obesity are poorly understood, and there is little information regarding genotype-phenotype correlations...
  92. ncbi Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase
    H Duplain
    Department of Internal Medicine, Division of Hypertension and Vascular Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Circulation 104:342-5. 2001
    ..Endothelial nitric oxide synthase (eNOS) is expressed in skeletal muscle, where it may govern metabolic processes, and in the vascular endothelium, where it regulates arterial pressure...
  93. pmc Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Diabetes 58:1532-8. 2009
    ....
  94. ncbi Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice
    Sihoon Lee
    Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892 0920, USA
    Am J Physiol Endocrinol Metab 294:E261-70. 2008
    ..This may reflect intrinsic differences between human and rodent physiology as well as increased technical difficulties in performing glucose clamps in mice...
  95. pmc Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth
    Serge Summermatter
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Diabetes 58:2228-37. 2009
    ..Our objective was to characterize the determinants of enhanced glucose utilization in adipose tissue during catch-up fat...
  96. pmc Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes
    Roope Mannikko
    Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U K
    Diabetes 60:1813-22. 2011
    ..A mutation at the same residue (E1506K) was previously shown to cause congenital hyperinsulinemia. We sought to understand why mutations at the same residue can cause either neonatal diabetes or hyperinsulinemia...
  97. pmc SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
    Derek M Erion
    Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven CT 06510, USA
    Proc Natl Acad Sci U S A 106:11288-93. 2009
    ..These results indicate that inhibition of hepatic SirT1 may be an attractive approach for treatment of T2DM...
  98. ncbi VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity
    Bettina Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 284:E708-15. 2003
    ..Glucose and insulin decrease VLDL-TG production in both lean men and lean women; obesity is associated with resistance to the glucose- and insulin-mediated suppression of VLDL-TG secretion in women, but not in men...
  99. ncbi The hyperinsulinism/hyperammonemia syndrome
    Andrew A Palladino
    The Children s Hospital of Philadelphia, Division of Endocrinology and Diabetes, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Rev Endocr Metab Disord 11:171-8. 2010
    The hyperinsulinism/hyperammonemia (HI/HA) syndrome is the second most common form of congenital hyperinsulinism (HI)...
  100. pmc Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase
    Changhong Li
    Division of Endocrinology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 285:31806-18. 2010
    The mechanism of insulin dysregulation in children with hyperinsulinism associated with inactivating mutations of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) was examined in mice with a knock-out of the hadh gene (hadh(-/-))...
  101. ncbi Roux-en-Y gastric bypass corrects hyperinsulinemia implications for the remission of type 2 diabetes
    Melissa A Reed
    Department of Exercise and Sport Science, Brody Medical School, East Carolina University, Greenville, North Carolina 27834, USA
    J Clin Endocrinol Metab 96:2525-31. 2011
    ..Roux-en-Y gastric bypass (RYGB) has been shown to induce rapid and durable reversal of type 2 diabetes...

Research Grants74

  1. Neural Functioning of Feeding Centers in Obese Youth
    ROBERT STANLEY SHERWIN; Fiscal Year: 2013
    ....
  2. DNA Repair Deficiency Associated with Obesity and the Metabolic Syndrome
    R Stephen Lloyd; Fiscal Year: 2013
    ..These investigations will examine the role of reduced DNA repair in the onset and progression of these diseases. ..
  3. Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
    Robert V Farese; Fiscal Year: 2013
    ..abstract_text> ..
  4. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    ..Funding of this proposal will also allow the PI, as an Early-Stage Investigator, to establish a fully-independent research program in the field of reproductive endocrinology. ..
  5. Lifespan Extension Despite Greatly Elevated Insulin and Body Fat
    David E Harrison; Fiscal Year: 2013
    ..Effects of DR that extend life spans in both normal control and ob/ob mice in this study are likely targets for interventions to retard aging and extend healthy lifespan in human beings. ..
  6. Imaging of Aortic Atherosclerosis and Inflammation in the Metabolic Syndrome
    Warren J Manning; Fiscal Year: 2012
    ....
  7. Role of the insulin/IGF-axis in incident CIN-2+
    Howard D Strickler; Fiscal Year: 2010
    ....
  8. Tunable Insulin Resistance in a Drosophila Model of Diabetes
    ELENA M GRACHEVA; Fiscal Year: 2010
    ....
  9. Maternal Hyperinsulinemia and Fetal Programming
    Mulchand S Patel; Fiscal Year: 2011
    ..Intervention measures proposed for the prevention of the malprogramming effects may lead to development of effective treatment options for curbing the human obesity epidemic. ..
  10. CEACAM1: A link between metabolic and cardiovascular diseases
    Sonia M Najjar; Fiscal Year: 2013
    ..Answering these questions will delineate new CEACAM1-dependent mechanisms underlying atherosclerosis along the liver/endothelial cell axis, and pinpoint sites of pharmacologic intervention. ..
  11. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..18F-FDOPA was used to diagnose infants with congenital hyperinsulinism. The ability to diagnose insulin-related disorders is in great need and the various approaches reported thus ..
  12. Development of New Therapeutics for Pancreatic Cancer Management
    RICHARD JOSEPH PIETRAS; Fiscal Year: 2013
    ..Discovery and validation of potent antitumor action and tolerability of metformin analogs in vivo may lead to timely clinical trials and possibly a significant breakthrough in pancreatic cancer therapy. ..
  13. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ....
  14. Activation of Atypical PKC by Insulin and Other Agonists
    ROBERT VITO FARESE; Fiscal Year: 2013
    ..We are confident that the proposed studies will provide a new approach for effective treatment of O/MS and T2DM. ..
  15. THE ROLE OF THE AKT/PKB SIGNALING IN INSULIN ACTION
    MORRIS JAY BIRNBAUM; Fiscal Year: 2013
    ..It is the aim of these studies to understand why lipid metabolism is so disturbed in Type II Diabetes Mellitus and to identify novel targets to treat this aspect of the disease. ..
  16. Integration of PR and FoxO Signaling in Pituitary Gonadotropes
    Varykina G Thackray; Fiscal Year: 2010
    ....
  17. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Howard D Strickler; Fiscal Year: 2012
    ..The study will be conducted in a large, prospective cohort study of endometrial cancer (GOG-0210). ..
  18. Pathogenic Mechanisms of Fatty Liver Disease
    Mohammad S Siddiqui; Fiscal Year: 2011
    ....
  19. Insulin as a Regulator of Microvascular Exchange
    Virginia H Huxley; Fiscal Year: 2013
    ..abstract_text> ..
  20. Mechanisms of Membrane-Based Insulin Resistance &Therapeutic Reversal Strategies
    Jeffrey S Elmendorf; Fiscal Year: 2012
    ..We have also identified means to protect against this derangement, and further investigation of the mechanisms involved will hopefully lead to new therapeutic strategies to curtail the accelerated expansion of the T2D population. ..
  21. Aging, Inflammation and Exercise in Chronic Stroke
    Alice S Ryan; Fiscal Year: 2012
    ..This research will identify a strategy to treat insulin resistance in stroke survivors and establish the biological basis for recommending lifestyle modifications to reduce inflammation and improve the metabolic profile in stroke. ..
  22. The role of exposure to bioaccumulative organochlorine compounds on the occurrenc
    GEORGE E HOWELL; Fiscal Year: 2010
    ..If so, the present study will provide mechanisms through which these compounds promote this disease and will establish exposure to certain organochlorine compounds as a risk factor for the development of type 2 diabetes. ..
  23. Maternal Overweight: Consequences for Insulin Signaling in the Offspring
    Kartik Shankar; Fiscal Year: 2013
    ..Overall, these studies will elucidate important metabolic mechanisms in the offspring altered by maternal OW and high-fat diets, which may contribute to increased susceptibility to obesity. ..
  24. Hepatocyte Clock and Alcoholic Fatty Liver Injury
    SHANNON MARIE BAILEY; Fiscal Year: 2011
    ....
  25. ENaC Transport in Insulin Resistance: Role of Insulin &IGF-1 Receptors
    Vivek Bhalla; Fiscal Year: 2013
    ....
  26. Central Nervous System Mechanisms of Obesity Hypertension
    Sean D Stocker; Fiscal Year: 2012
    ..This application will identify the mechanisms in the brain that link obesity and hypertension, and therefore provide a framework for the development of novel therapeutic treatments in obese individuals. ..
  27. Time-of-Day-Dependent Feeding Influences Myocardial Function
    MARTIN ELLIOT YOUNG; Fiscal Year: 2012
    ..Such findings could significantly re-shape human nutritional guidelines to include information on the appropriate time-of-day at which calorie-dense meals are consumed. ..
  28. Regulation of Metabolism by the Hormone FGF15/19
    Steven A Kliewer; Fiscal Year: 2013
    ..Insights from these studies may provide new clinical strategies for treating obesity, diabetes, and other forms of metabolic disease. ..
  29. Atypical Antipsychotics: Effects on Hepatic Glucose and Lipid Metabolism in Human
    Michael R Rickels; Fiscal Year: 2012
    ..Findings from these studies will have important clinical relevance to the treatment of schizophrenia. ..
  30. Role of the MC3-R in Obesity and Metabolic Syndrome
    Roger D Cone; Fiscal Year: 2012
    ..This application seeks to identify the sites and mechanisms of action of the MC3-R in this phenomenon, so as to better understand the etiology, and eventually discover better treatments for metabolic syndrome. ..
  31. Epigenomic impact of diet and toxicant exposure in Alzheimers disease etiology
    Iliya Lefterov; Fiscal Year: 2013
    ....
  32. Effect of Insulin on Estrogen Receptor Alpha Activity in Human Endometrial Cells
    CLARE ANN FLANNERY; Fiscal Year: 2013
    ..Also, the treatment paradigm for women with T2DM may change to limit exposure to high doses of therapeutic insulin. ..
  33. The Common Marmoset as a Primate Model of Maternal Obesity
    SUZETTE D contact TARDIF; Fiscal Year: 2010
    ....
  34. Age-Dependent Role of Bisphenol A in Nonalcoholic Fatty Liver Disease
    Andrew S Greenberg; Fiscal Year: 2013
    ....
  35. The Charge Study: Childhood Autism Risks from Genetics and the Environment
    Irva Hertz-Picciotto; Fiscal Year: 2013
    ..Results of this detailed inquir into early exposures, maternal pathophysiology and prognostic markers in the newborn will set the stage for developing prevention strategies. ..
  36. Reduction in CVD risk in children by physical activity
    Robert C Hickner; Fiscal Year: 2010
    ....
  37. Hepatic insulin resistance and metabolic disease
    Morris F White; Fiscal Year: 2013
    ....
  38. Dietary Factors in Colon Cancer Prevention
    FRANK ALBERT SIMMEN; Fiscal Year: 2013
    ..These studies have strong translational significance for improving the health and quality of life of the overweight/obese population at risk for or afflicted with colo-rectal cancer. ..
  39. Ultrasound Assessment of Microvascular Function in Insulin Resistant Primates
    Jonathan R Lindner; Fiscal Year: 2011
    ..These studies will be vital not only for understanding the pathophysiology of diabetes, but will also be important for establishing a method to test new treatment strategies or diagnostic strategies for early diabetic risk profiling. ..
  40. Mechanisms of PPAR-gamma Enhancement of Cognitive Function in Alzheimer's Disease
    Kelly T Dineley; Fiscal Year: 2013
    ..These findings will have significant impact on our understanding of, and treatment options for, Alzheimer's disease. ..
  41. 2-pore-domain K+ channels as novel targets for modulating islet hormone secretion
    DAVID AARON JACOBSON; Fiscal Year: 2013
    ....
  42. Regulation of SREBP-1c Processing by Insulin and Cyclic-AMP
    Marshall B Elam; Fiscal Year: 2010
    ..The goal of this research is to identify new treatments for hyperlipidemia by understanding the mechanisms by which insulin regulates this protein. ..
  43. Liver Glucose Flux in Obesity and Diabetes
    Masakazu Shiota; Fiscal Year: 2013
    ..Understanding how chronic hyperglycemia impairs the action of glucose and/or insulin on the liver in terms of glucose and lipid metabolism will provide the basis for improved treatment of type 2 diabetes. ..
  44. Periventricular White Matter Injury Prevention
    Scott A Rivkees; Fiscal Year: 2013
    ..by the US Food and Drug Administration (FDA) for the acute treatment of hypertension and the treatment of hyperinsulinism in infants15-16...
  45. Follicular and endometrial pathology in polycystic ovary syndrome
    ANNE ELIZABETH NEWELL-FUGATE; Fiscal Year: 2011
    ..Further characterization of such a model animal will establish its utility in the development and testing of new clinical treatments for the reproductive and endocrine symptoms of PCOS. ..
  46. Adipose Tissue Amyloid Precursor Protein and Beta-Amyloid
    William G Tharp; Fiscal Year: 2013
    ....
  47. Parathyroid Hormone-Related Protein and the Pancreatic Beta Cell
    Rupangi C Vasavada; Fiscal Year: 2012
    ....
  48. The mTORCI-miR-29-AT2R axis in cardiovascular diseases
    Lakshmidevi Pulakat; Fiscal Year: 2013
    ..We expect that the results of these studies will have significant translational value since they will have considerabl impact on the standard of care for CVD in MetS. ..
  49. The effect of exercise on hepatic glucose metabolism in type 2 diabetes mellitus
    JASON JOSEPH WINNICK; Fiscal Year: 2013
    ....
  50. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010
    ....
  51. Selenium Colorectal Cancer Chemoprevention Trials
    PATRICIA ANN THOMPSON; Fiscal Year: 2013
    ..In secondary analyses, we will investigate whether or not baseline Se levels, genetic background, and/or use of low-dose aspirin modify Se effects on CRA occurrence or risk for T2D. ..
  52. The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes.
    Jenny Tong; Fiscal Year: 2013
    ..The knowledge gained from this project will be pivotal in determining whether the ghrelin system can be used as a drug target for the treatment of T2DM. ..
  53. Studying the Progression and Regression of Beta Cell Dysfunction in Type 2 Diabet
    Shuibing Chen; Fiscal Year: 2012
    ..We propose to use two models containing human islet cells to study the progression and regression of type 2 diabetes mellitus. Using the proposed study, we will learn how to prevent or treat Type 2 diabetes mellitus. ..
  54. Follicular and endometrial pathology in polycystic ovary syndrome
    ANNE ELIZABETH NEWELL-FUGATE; Fiscal Year: 2013
    ..Lastly, the research proposed and career development and training activities outlined, will prepare Dr. Newell-Fugate for the independent investigator stage of her scientific career. ..
  55. Hyperamylinemia in Diabetic Heart Disease: Mechanisms, Responses, and Prevention
    Florin Despa; Fiscal Year: 2013
    ..If our hypothesis of cardiotoxic amylin oligomer is proven, then circulating amylin oligomers are a feasible therapeutic target to reduce diabetic heart injury. ..
  56. Insulin Resistance, Vascular Stiffness, and Hypertension
    Philip S Tsao; Fiscal Year: 2013
    ..Finally, direct inhibition of Cbfa1 activity will test whether targeting vascular stiffness will have benefit in inhibiting development of hypertension. ..
  57. Structural Basis of Katp Channel Gating
    Show Ling Shyng; Fiscal Year: 2013
    ..Mutations in Kir6.2 or SUR1 that reduce channel function cause congenital hyperinsulinism whereas those that increase channel function cause neonatal diabetes. Both Kir6...
  58. The Functional Role of the PXL Domain of SGK1 in Epithelial Sodium Transport
    Alan C Pao; Fiscal Year: 2010
    ..UCSF offers the scientific expertise and the technical resources to provide an ideal environment for preparing this candidate for a successful career as a physician-scientist. ..
  59. Mechanisms for Increased Breast Cancer Risk in Type 2 Diabetes
    Derek LeRoith; Fiscal Year: 2013
    ....
  60. Islet Dysregulation in Infants with Congenital Hyperinsulinism
    CHARLES ALFRED STANLEY; Fiscal Year: 2013
    Project Summary Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in infants and children...
  61. CEACAM AND INSULIN ACTION
    Sonia M Najjar; Fiscal Year: 2013
    ..This should provide a critical test of the causative effect of hyperinsulinemia on insulin resistance, and identify CEACAM1 as a tractable drug target for the development of medications to combat altered metabolic conditions. ..
  62. Insulin Resistance and Breast Cancer Prognosis in Black &White Women
    Derek LeRoith; Fiscal Year: 2013
    ..Samples of breast cancer tissue removed during primary surgical resection will be examined using immunohistochemistry to assess the role of insulin, insulin-like disparities in breast cancer prognosis between racial groups. ..
  63. Rosiglitazone and Clomiphene for Ovulation Induction
    Nicholas Cataldo; Fiscal Year: 2002
    ..The effects of rosiglitazone on insulin secretion on OGTT will be correlated with its effects on the levels of the above hormones and binding proteins. ..
  64. Walnuts vs. Walnut-Oil, Glucose Homeostasis, PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  65. GLUCONEOGENESIS & DE NOVO LIPOGENESIS IN CYSTIC FIBROSIS
    DANA HARDIN; Fiscal Year: 2000
    ....
  66. Role of GLP-1 in Congenital Hyperinsulinism
    DIVA DEL CARMEN DE LEON; Fiscal Year: 2010
    ..This is a translational research study of the role of glucagon-like peptide-1 (GLP-1) in congenital hyperinsulinism (CHI), the most frequent cause of persistent hypoglycemia in children...
  67. Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOS
    SIDIKA KARAKAS; Fiscal Year: 2009
    ..Our aim is to identify the best supplement that can prevent hypoglycemia and its unwanted consequences in these young women-an under-studied patient population. ..
  68. Leptin modulation of insulin action in the islet b-cell
    Rohit Kulkarni; Fiscal Year: 2005
    ..abstract_text> ..
  69. Coupling of D-chiro-inositol to insulin in PCOS women
    MARIA IUORNO; Fiscal Year: 2004
    ..abstract_text> ..
  70. DIABETES RISK FACTORS IN ALASKAN AND SIBERIAN ESKIMOS
    Sven Ebbesson; Fiscal Year: 1991
    ....
  71. ENDOCRINE AND NUTRITIONAL FACTORS IN OBESITY
    LARYSSA KAUFMAN; Fiscal Year: 1990
    ..Thus, the results of the proposed studies will extend our understanding of the role of insulin and diet in the pathogenesis of obesity...
  72. Insulin, Renal Sodium Transport and Blood Pressure
    Carolyn Ecelbarger; Fiscal Year: 2006
    ..These studies will, hopefully, provide us with an enlightened understanding of the role of insulin in sodium balance. ..
  73. MECHANISMS UNDERLYING CARDIOVASCULAR RISKS IN DIABETES
    Gordon Williams; Fiscal Year: 2000
    ..With this information, specific preventive and therapeutic measures could then be tested as to their efficacy in retarding the development of these complications. ..
  74. OOCYTE COMPETENCY IN PRENATALLY ANDROGENIZED ANIMALS
    DANIEL DUMESIC; Fiscal Year: 2000
    ..The experimental data will be used for future studies that will investigate how polypeptide growth/differentiation factors of granulosa cell origin participate in the regulation of ovarian function. ..