glucose intolerance

Summary

Summary: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.

Top Publications

  1. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
  2. ncbi Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?
    Kennedy Cruickshank
    Clinical Epidemiology Group, School of Epidemiology and Health Sciences, University of Manchester Medical School, Manchester, UK
    Circulation 106:2085-90. 2002
  3. ncbi Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
    Ranganath Muniyappa
    Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, 9 Memorial Drive, Bldg 9, Rm 1N 105 MSC 0920, Bethesda, MD 20892, USA
    Am J Physiol Endocrinol Metab 294:E15-26. 2008
  4. ncbi Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    Katherine Esposito
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Italy
    Circulation 106:2067-72. 2002
  5. ncbi Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention
    N Unwin
    Diabetes and Metabolism, School of Clinical Medical Sciences, University of New Castle, UK
    Diabet Med 19:708-23. 2002
  6. pmc Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis
    Clare L Gillies
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester LE1 7RH
    BMJ 334:299. 2007
  7. pmc alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population
    Walter E Gall
    Metabolon, Inc, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 5:e10883. 2010
  8. ncbi A model-based method for assessing insulin sensitivity from the oral glucose tolerance test
    A Mari
    Institute of Systems Science and Biomedical Engineering, National Research Council, Padova, Italy
    Diabetes Care 24:539-48. 2001
  9. pmc Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
    Shi Bing Yang
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 1550, 4th Street, San Francisco, CA 94158, USA
    J Mol Med (Berl) 90:575-85. 2012
  10. pmc Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    Maziyar Saberi
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Metab 10:419-29. 2009

Detail Information

Publications313 found, 100 shown here

  1. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
    ..Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high risk for the disease is not known...
  2. ncbi Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?
    Kennedy Cruickshank
    Clinical Epidemiology Group, School of Epidemiology and Health Sciences, University of Manchester Medical School, Manchester, UK
    Circulation 106:2085-90. 2002
    ..We tested whether aortic PWV predicts cardiovascular and all-cause mortality in type 2 diabetes and glucose-tolerance-tested (GTT) multiethnic population samples...
  3. ncbi Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
    Ranganath Muniyappa
    Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, 9 Memorial Drive, Bldg 9, Rm 1N 105 MSC 0920, Bethesda, MD 20892, USA
    Am J Physiol Endocrinol Metab 294:E15-26. 2008
    ..In this Frontiers article, we highlight merits, limitations, and appropriate use of current in vivo measures of insulin sensitivity/resistance...
  4. ncbi Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    Katherine Esposito
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Italy
    Circulation 106:2067-72. 2002
    ..We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione...
  5. ncbi Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention
    N Unwin
    Diabetes and Metabolism, School of Clinical Medical Sciences, University of New Castle, UK
    Diabet Med 19:708-23. 2002
    ..The consensus of the workshop was: 1. The diagnostic thresholds for all categories of glucose intolerance should be revisited in the light of the latest evidence...
  6. pmc Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis
    Clare L Gillies
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester LE1 7RH
    BMJ 334:299. 2007
    ..To quantify the effectiveness of pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance...
  7. pmc alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population
    Walter E Gall
    Metabolon, Inc, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 5:e10883. 2010
    ..Current diagnostic tests, such as glycemic indicators, have limitations in the early detection of insulin resistant individuals. We searched for novel biomarkers identifying these at-risk subjects...
  8. ncbi A model-based method for assessing insulin sensitivity from the oral glucose tolerance test
    A Mari
    Institute of Systems Science and Biomedical Engineering, National Research Council, Padova, Italy
    Diabetes Care 24:539-48. 2001
    ..We used a glucose-insulin model to derive an OGTT-based IS (oral glucose insulin sensitivity [OGIS]) index, which predicts glucose clearance in a glucose clamp. We validated OGIS against clamp data...
  9. pmc Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
    Shi Bing Yang
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 1550, 4th Street, San Francisco, CA 94158, USA
    J Mol Med (Berl) 90:575-85. 2012
    ..The multitude of rapamycin effects thus all lead to glucose intolerance. As our findings reveal that chronic rapamycin treatment could be diabetogenic, monitoring glucose ..
  10. pmc Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    Maziyar Saberi
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Metab 10:419-29. 2009
    ..After 16 weeks of a high-fat diet (HFD), BMT-WT mice developed obesity, hyperinsulinemia, glucose intolerance, and insulin resistance...
  11. ncbi Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)
    Elizabeth L M Barr
    International Diabetes Institute, 250 Kooyong Rd, Caulfield, Victoria, 3162, Australia
    Circulation 116:151-7. 2007
    ..This study investigated whether impaired fasting glucose and impaired glucose tolerance, as well as diabetes mellitus, increase the risk of all-cause and CVD mortality...
  12. pmc Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    Amandine Everard
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Diabetes 60:2775-86. 2011
    ..To investigate deep and comprehensive analysis of gut microbial communities and biological parameters after prebiotic administration in obese and diabetic mice...
  13. ncbi Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD21224, USA
    Am J Epidemiol 160:521-30. 2004
    Clinic-based studies suggest that sleep-disordered breathing (SDB) is associated with glucose intolerance and insulin resistance...
  14. pmc Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease
    Steven D Kunkel
    Department of Internal Medicine, and Fraternal Order of Eagles Diabetes Research Center, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e39332. 2012
    Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose intolerance and fatty liver disease...
  15. pmc Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions
    Robert E Ratner
    MedStar Research Institute, Hyattsville, Maryland 20783, USA
    J Clin Endocrinol Metab 93:4774-9. 2008
    ..A past history of gestational diabetes mellitus (GDM) confers a very high risk of postpartum development of diabetes, particularly type 2 diabetes...
  16. ncbi A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice
    A A Toye
    Medical Research Council, Harwell, Didcot, Oxfordshire, UK
    Diabetologia 48:675-86. 2005
    ..C57BL/6J mice exhibit impaired glucose tolerance. The aims of this study were to map the genetic loci underlying this phenotype, to further characterise the physiological defects and to identify candidate genes...
  17. ncbi The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes
    Maria Sörhede Winzell
    Dept of Medicine, Biomedical Center BMC, B11, S 221 84 Lund, Sweden
    Diabetes 53:S215-9. 2004
    ..Intravenous glucose challenge revealed a severely compromised insulin response in association with marked glucose intolerance already after 1 week...
  18. pmc Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance
    Libin Liu
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Cell Metab 8:310-7. 2008
    ..normal weight but have higher circulating triglyceride levels, significantly reduced adipose tissue mass, glucose intolerance, and hyperinsulinemia--characteristics that constitute a lipodystrophic phenotype...
  19. ncbi Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test
    Muhammad A Abdul-Ghani
    Division of Diabetes, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Diabetes Care 30:89-94. 2007
    ..To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT)...
  20. ncbi The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study
    David W Dunstan
    International Diabetes Institute, Melbourne, Australia
    Diabetes Care 25:829-34. 2002
    To determine the population-based prevalence of diabetes and other categories of glucose intolerance (impaired glucose tolerance [IGT] and impaired fasting glucose [IFG]) in Australia and to compare the prevalence with previous ..
  21. pmc Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    Vanessa P Houde
    Department of Medicine, Faculty of Medicine, Cardiology Axis of the Quebec Heart and Lung Institute, and the Metabolism, Vascular and Renal Health Axis, Laval University Hospital Research Center, Laval University, Quebec, Canada
    Diabetes 59:1338-48. 2010
    ....
  22. pmc MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease
    Lars Verschuren
    TNO Quality of Life, Biosciences, Leiden, The Netherlands
    Circ Res 105:99-107. 2009
    ..This study examines whether MIF is required for the development of obesity, IR, glucose intolerance, and atherosclerosis in the LDL receptor-deficient (Ldlr(-/-)) mouse model of disease...
  23. ncbi Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome
    D A Ehrmann
    Department of Medicine, University of Chicago, Illinois, USA
    Diabetes Care 22:141-6. 1999
    ..The objective of this study was to characterize the prevalence and incidence of glucose intolerance in a large cohort of women with well-characterized PCOS.
  24. pmc Chronic phase shifts of the photoperiod throughout pregnancy programs glucose intolerance and insulin resistance in the rat
    Tamara J Varcoe
    Research Centre for Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia
    PLoS ONE 6:e18504. 2011
    ..These results highlight the need for a thorough analysis of shift work exposure in utero on the health of the adult offspring in humans...
  25. ncbi Global and societal implications of the diabetes epidemic
    P Zimmet
    International Diabetes Institute, 260 Kooyong Road, Caulfield, Victoria 3162, Australia
    Nature 414:782-7. 2001
    ..The prevention of diabetes and control of its micro- and macrovascular complications will require an integrated, international approach if we are to see significant reduction in the huge premature morbidity and mortality it causes...
  26. pmc Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:1212-21. 2009
    ....
  27. ncbi Rapamycin-induced glucose intolerance: hunger or starvation diabetes
    Mikhail V Blagosklonny
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 10:4217-24. 2011
    ..However, under certain conditions, chronic administration of rapamycin may cause glucose intolerance and even provoke type II diabetes...
  28. pmc Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance
    Matthew C Ernst
    Department of Pharmacology, Dalhousie University, 5850 College Street, P O Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
    Endocrinology 153:672-82. 2012
    ....
  29. ncbi Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:464-9. 2008
    ..The aim of this study was to determine the prevalence and risk factors of polyneuropathy in subjects with diabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or normal glucose tolerance (NGT)...
  30. pmc Effect of maternal weight, adipokines, glucose intolerance and lipids on infant birth weight among women without gestational diabetes mellitus
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ont
    CMAJ 184:1353-60. 2012
    ..We sought to evaluate the independent effects of maternal glycemia, lipids, obesity, adipokines and inflammation on infant birth weight...
  31. pmc Impaired glycemia and diabetic polyneuropathy: the OC IG Survey
    Peter J Dyck
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes Care 35:584-91. 2012
    ....
  32. pmc Lactation intensity and postpartum maternal glucose tolerance and insulin resistance in women with recent GDM: the SWIFT cohort
    Erica P Gunderson
    Division of Research, Kaiser Permanente Northern California, Oakland, California, USA
    Diabetes Care 35:50-6. 2012
    ..the association between breastfeeding intensity in relation to maternal blood glucose and insulin and glucose intolerance based on the postpartum 2-h 75-g oral glucose tolerance test (OGTT) results at 6-9 weeks after a pregnancy ..
  33. pmc PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance
    Sang Jun Lee
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Cell Metab 12:65-77. 2010
    ..of PKCzeta in vivo leads to a hyperinflammatory state in obese mice that correlates with a higher glucose intolerance and insulin resistance...
  34. ncbi High prevalence of undiagnosed diabetes mellitus in Southern Germany: target populations for efficient screening. The KORA survey 2000
    W Rathmann
    Dept of Biometrics and Epidemiology, German Diabetes Research Institute at Düsseldorf University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetologia 46:182-9. 2003
    ....
  35. ncbi The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1)
    A Ramachandran
    Diabetes Research Centre, M V Hospital for Diabetes, WHO Collaborating Centre for Research, Education and Training in Diabetes, Royapuram, Chennai, India
    Diabetologia 49:289-97. 2006
    ..In a prospective community-based study, we tested whether the progression to diabetes could be influenced by interventions in native Asian Indians with IGT who were younger, leaner and more insulin resistant than the above populations...
  36. pmc Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 31:2026-31. 2008
    ....
  37. ncbi Increased prevalence of impaired glucose tolerance in patients with painful sensory neuropathy
    J R Singleton
    Division of Neuromuscular Disease, Department of Neurology, University of Utah, Salt Lake City, Utah 84132, USA
    Diabetes Care 24:1448-53. 2001
    ..neuropathy at the time of their diagnosis, suggesting that axonal injury may occur early in the course of glucose intolerance. The American Diabetes Association (ADA) revised diagnostic criteria to recognize IGT (a serum glucose ..
  38. ncbi Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice
    Kazue Ohmura
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Arterioscler Thromb Vasc Biol 30:193-9. 2010
    ..Natural killer T (NKT) cells, which integrate proinflammatory cytokines, have been demonstrated in the atherosclerotic lesions and in visceral adipose tissue...
  39. ncbi Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice
    Elodie Riant
    Institut National de la Santé et de la Recherche Médicale Unité 858, Institut de Medecine Moleculaire de Rangueil, Boite Postale 84225, 31432 Toulouse Cedex 4, France
    Endocrinology 150:2109-17. 2009
    ..observed in normal chow diet-fed mice, E2 administration exerted a protective effect against HFD-induced glucose intolerance, and this beneficial action was abolished in ERalpha-deficient mice...
  40. pmc Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia
    Guo Lian Ding
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Diabetes 61:1133-42. 2012
    ..Furthermore, altered Igf2 and H19 gene expression was found in sperm of adult F1-GDM, regardless of the presence of IGT, indicating that changes of epigenetics in germ cells contributed to transgenerational transmission...
  41. ncbi Fructose consumption during pregnancy and lactation induces fatty liver and glucose intolerance in rats
    Mi Zou
    Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN 47907 2054, USA
    Nutr Res 32:588-98. 2012
    ..0 mg/g vs 19.9 ± 12.6 mg/g liver weight) compared with CT-fed dams. Fructose induced fatty liver and glucose intolerance in pregnant and lactating rats, but not unmated CT rats...
  42. pmc Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models
    Bilal Omar
    Department of Clinical Sciences, Medicine, Lund University, SE221 84, Lund, Sweden
    Nutrients 4:1367-81. 2012
    ..Different high fat diets are used and in order to determine which diet produces a model most accurately resembling human T2D, they need to be compared head-to-head...
  43. pmc Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas
    Elena Kostromina
    Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, Singapore 138667
    Endocrinology 151:2050-9. 2010
    ..The p-KO mice exhibited glucose intolerance and impaired insulin secretion in vivo but normal insulin secretion in isolated islets...
  44. ncbi Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance
    Steen Larsen
    Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Am Coll Cardiol 61:44-53. 2013
    ....
  45. pmc Erythropoietin inhibits gluconeogenesis and inflammation in the liver and improves glucose intolerance in high-fat diet-fed mice
    Ran Meng
    Department of Endocrinology, Nanjing Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, China
    PLoS ONE 8:e53557. 2013
    ..the body weights and the levels of fasting blood glucose and serum insulin and improved the HFD-induced glucose intolerance in mice...
  46. ncbi Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113)
    Karunakaran Indulekha
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialities Centre, WHO Collaborating Centre for Non communicable Diseases Prevention and Control, International Diabetes Federation IDF Centre for Education, Gopalapuram, Chennai 600086, India
    Clin Biochem 44:281-7. 2011
    The aim of the study was to assess the association between visceral and subcutaneous fat with glucose intolerance, adipocytokines, inflammatory markers and carotid IMT in Asian Indians.
  47. ncbi Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002
    Catherine C Cowie
    Diabetes Epidemiology Program, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 6707 Democracy Blvd, Rm 691, MSC 5460, Bethesda, MD 20892 5460, USA
    Diabetes Care 29:1263-8. 2006
    ..The purpose of this study was to examine the prevalences of diagnosed and undiagnosed diabetes, and impaired fasting glucose (IFG) in U.S. adults during 1999-2002, and compare prevalences to those in 1988-1994...
  48. ncbi A low socio-economic status is an additional risk factor for glucose intolerance in high risk Hong Kong Chinese
    G T Ko
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, NT, PR China
    Eur J Epidemiol 17:289-95. 2001
    To examine whether a low socio-economic status (SES) is an additional risk factor for glucose intolerance in Hong Kong Chinese with known risk factors for glucose intolerance, a total of 2847 Chinese subjects (473 men and 2374 women) ..
  49. pmc One-hour postload plasma glucose levels and left ventricular mass in hypertensive patients
    Angela Sciacqua
    Department of Experimental and Clinical Medicine G Salvatore, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Diabetes Care 34:1406-11. 2011
    ..We addressed the question if glucose tolerance status, particularly 1-h postload plasma glucose levels, affects left ventricular mass (LVM) and cardiac geometry in essential hypertension...
  50. pmc Arsenate-induced maternal glucose intolerance and neural tube defects in a mouse model
    Denise S Hill
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, 77030, USA
    Toxicol Appl Pharmacol 239:29-36. 2009
    ..Periconceptional hyperglycemia is a significant risk factor for neural tube defects (NTDs), the second most common structural birth defect. A suspected teratogen, arsenic (As) induces NTDs in laboratory animals...
  51. ncbi PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
    Tetsuyuki Yasuda
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Diabetes 51:224-30. 2002
    ..factors such as IPF1/IDX-1/STF-1/PDX-1 and NEUROD1/BETA2 serve as a genetic cause of diabetes or glucose intolerance, we investigated the possibility of PAX6 gene mutations being a genetic factor common to aniridia and ..
  52. ncbi Population-based study of diabetes and risk characteristics in Turkey: results of the turkish diabetes epidemiology study (TURDEP)
    Ilhan Satman
    Division of Diabetes, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Diabetes Care 25:1551-6. 2002
    To investigate for the first time the prevalence of diabetes and impaired glucose tolerance (IGT) nationwide in Turkey; to assess regional variations and relationships between glucose intolerance and lifestyle and physical risk factors.
  53. ncbi Glucose intolerance and resistin expression in rat offspring exposed to ethanol in utero: modulation by postnatal high-fat diet
    Li Chen
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3A1R9
    Endocrinology 144:500-8. 2003
    ..The data suggest that high-fat diet worsens glucose intolerance in offspring of rats exposed to ETOH...
  54. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  55. pmc Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality
    Melany Castillo
    Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida, USA
    Diabetes 60:1082-9. 2011
    ..Here we investigate whether the impaired thermogenesis of D2KO mice increases their susceptibility to obesity when placed on a high-fat diet...
  56. ncbi Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance
    Lindsey N Sutherland
    Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Endocrinol Metab 295:E1076-83. 2008
    ..Thus, reductions in adipose tissue mitochondrial proteins are most likely not a causal event in the development of impaired glucose homeostasis...
  57. ncbi Work stress and low sense of coherence is associated with type 2 diabetes in middle-aged Swedish women
    Emilie E Agardh
    Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institutet, Stockholm, Sweden
    Diabetes Care 26:719-24. 2003
    ..Finally, we investigated the combination of SOC and demands or SOC and decision latitude in association with the disease...
  58. ncbi A cross-sectional study of the association between persistent organic pollutants and glucose intolerance among Greenland Inuit
    M E Jørgensen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetologia 51:1416-22. 2008
    ..Thus the aim was to study the association between POPs and glucose intolerance and markers of insulin resistance and insulin secretion using a population-based design.
  59. ncbi Glucose intolerance in teleost fish: fact or fiction?
    T W Moon
    Department of Biology, University of Ottawa, P O Box 450, Stn A, K1N 6N5, Ottawa, ON, Canada
    Comp Biochem Physiol B Biochem Mol Biol 129:243-9. 2001
    ..This mini-review examines some of the background and the possible mechanistic bases for this statement. Glucose intolerance is a clinical mammalian term meaning that a glucose load results in persistent hyperglycemia...
  60. ncbi Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice
    Helen C Freeman
    Medical Research Council, Mammalian Genetics Unit, Harwell, Oxfordshire, UK
    Diabetes 55:2153-6. 2006
    The C57BL/6J mouse displays glucose intolerance and reduced insulin secretion...
  61. pmc Hypertriglyceridemic-waist phenotype and glucose intolerance among Canadian Inuit: the International Polar Year Inuit Health Survey for Adults 2007-2008
    Grace M Egeland
    Centre for Indigenous Peoples Nutrition and Environment and School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec
    CMAJ 183:E553-8. 2011
    ..We conducted a population-based screening for diabetes among Inuit in the Canadian Arctic and evaluated the association of visceral adiposity with diabetes...
  62. pmc Glucose intolerance in pregnancy and postpartum risk of metabolic syndrome in young women
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Toronto, Canada M5T3L9
    J Clin Endocrinol Metab 95:670-7. 2010
    Gestational diabetes mellitus (GDM) and even mild glucose intolerance in pregnancy are both associated with increased risks of developing type 2 diabetes and cardiovascular disease in the future...
  63. pmc Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function
    Simone Renner
    Chair for Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis, Gene Center, Ludwig Maximilians University LMU Munich, Munich, Germany
    Diabetes 59:1228-38. 2010
    ....
  64. pmc Serum 25-hydroxy vitamin d and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans
    Nicole R Pinelli
    Department of Pharmacy Practice, Wayne State University, Detroit, Michigan, USA
    Diabetes Care 33:1373-5. 2010
    To describe 25-hydroxy vitamin D (25-OH-D) levels and examine associations between 25-OH-D levels and insulin resistance (IR), metabolic syndrome (MS), and glucose intolerance in Arab Americans.
  65. ncbi Chronic intake of high-fat and high-sucrose diets differentially affects glucose intolerance in mice
    Maho Sumiyoshi
    Division of Functional Histology, Department of Integrated Basic Medical Science, Ehime University, Shitsukawa, Toon City, Japan
    J Nutr 136:582-7. 2006
    ..The HF and HS diets resulted in different types of glucose intolerance. In an oral glucose tolerance test, mice fed the HF diet had a delay in the clearance of glucose compared ..
  66. ncbi Glucose intolerance and associated factors in the multi-ethnic population of the United Arab Emirates: results of a national survey
    M Malik
    Ministry of Health, Abu Dhabi, United Arab Emirates
    Diabetes Res Clin Pract 69:188-95. 2005
    ..To determine the prevalence of diabetes and impaired fasting glycaemia (IFG) and associated conditions such as obesity and hypertension, in the multi-ethnic, adult population of the United Arab Emirates in 1999-2000...
  67. ncbi Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivity in Chinese subjects
    Huating Li
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai 200233, China
    J Clin Endocrinol Metab 94:2151-6. 2009
    ..This study investigated the association of serum FGF21 levels with insulin secretion and sensitivity, as well as circulating parameters of lipid metabolism and hepatic enzymes in Chinese subjects...
  68. ncbi Atlantic DIP: high prevalence of abnormal glucose tolerance post partum is reduced by breast-feeding in women with prior gestational diabetes mellitus
    Michael W O'Reilly
    Atlantic DIP Investigators, Department of Endocrinology and Diabetes Mellitus, University College Hospital National University of Ireland, Galway, Republic of Ireland
    Eur J Endocrinol 165:953-9. 2011
    ..Our objective was to identify the prevalence of post partum dysglycemia after GDM, to delineate associated factors and to examine the effect of lactation on post partum glucose tolerance...
  69. ncbi Transgenerational inheritance of glucose intolerance in a mouse model of neonatal overnutrition
    Thais Pentinat
    Fundació Sant Joan de Déu, Barcelona, Spain
    Endocrinology 151:5617-23. 2010
    ..ON-F0 mice developed many features of the metabolic syndrome, including obesity, insulin resistance, and glucose intolerance. We then studied whether male offspring (ON-F1) and grand-offspring (ON-F2) of ON-F0 male mice, which were ..
  70. ncbi Sex differences in lipid profiles in relation to the progression of glucose abnormalities
    Gian P Carnevale Schianca
    Internal Medicine, Department of Clinical and Experimental Medicine, University of Eastern Piedmont A Avogadro, Novara, Italy
    J Diabetes 4:95-101. 2012
    ..In the present study, we investigated the role of changes in blood lipids in the abolition of the lower cardiovascular risk associated with the female gender in individuals with type 2 diabetes mellitus (T2DM)...
  71. ncbi Role of vitamin D in the pathogenesis of type 2 diabetes mellitus
    X Palomer
    Institut de Recerca, Hospital de Santa Creu i Sant Pau, Barcelona, Spain
    Diabetes Obes Metab 10:185-97. 2008
    ..It has been reported that vitamin D deficiency may predispose to glucose intolerance, altered insulin secretion and type 2 diabetes mellitus...
  72. ncbi A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    Renata Belfort
    University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    N Engl J Med 355:2297-307. 2006
    ..Pioglitazone is a thiazolidinedione that ameliorates insulin resistance and improves glucose and lipid metabolism in type 2 diabetes mellitus...
  73. ncbi Significance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection
    Shuji Sumie
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka 830 0011, Japan
    Oncol Rep 18:545-52. 2007
    b>Glucose intolerance frequently is found in hepatocellular carcinoma (HCC) patients with hepatitis C virus (HCV) infection; however, the significance of glucose intolerance remains unclear...
  74. ncbi Glucose intolerance in cystic fibrosis patients
    S Lanng
    Department of Paediatrics, Rigshospitalet, CF Centre Copenhagen, Copenhagen, Denmark
    Paediatr Respir Rev 2:253-9. 2001
    ..CFRD patients have an increased mortality compared to non-diabetic CF patients. Insulin therapy is the preferred treatment...
  75. ncbi The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 95:4345-53. 2010
    ..Because lipid factors can contribute to cardiovascular risk, we sought to characterize the relationship between gestational glucose tolerance status and lipid profile in pregnancy and the postpartum...
  76. ncbi An epidemiologic study on the prevalence of diabetes, glucose intolerance, and metabolic syndrome in the adult population of the Republic of Cyprus
    Theodoros Loizou
    Diabetes Care 29:1714-5. 2006
  77. ncbi Neuropathy and impaired glucose tolerance: an updated review of the evidence
    Y A Rajabally
    Neuromuscular Clinic, Department of Neurology, University Hospitals of Leicester, UK
    Acta Neurol Scand 124:1-8. 2011
    ..However, at present time, consideration of IGT as potential cause of painful small-fibre neuropathy appears justified, especially as patients may benefit from dietary and physical exercise interventions...
  78. ncbi Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas)
    Bolleddula Jayaprakasam
    Bioactive Natural Products and Phytoceuticals, Department of Horticulture, Michigan State University, East Lansing, Michigan 48824, USA
    J Agric Food Chem 54:243-8. 2006
    ..The high-fat diet induced glucose intolerance, and this was prevented by anthocyanins and ursolic acid...
  79. pmc Telomerase deficiency impairs glucose metabolism and insulin secretion
    Doreen Kuhlow
    Department of Human Nutrition, Inst of Nutrition, University of Jena, Germany
    Aging (Albany NY) 2:650-8. 2010
    ..telomerase deficiency and hence short telomeres impair replicative capacity of pancreatic beta-cells to cause impaired insulin secretion and glucose intolerance, mechanistically defining diabetes mellitus as an aging-associated disorder.
  80. pmc Is there a link between components of health-related functioning and incident impaired glucose metabolism and type 2 diabetes? The Australian Diabetes Obesity and Lifestyle (AusDiab) study
    Robyn J Tapp
    Department of Medicine, Monash Medical Centre Southern Clinical School, Monash University, Victoria, Australia
    Diabetes Care 33:757-62. 2010
    ..To determine the longitudinal association of components of health-related functioning (HRF) with incident impaired glucose metabolism and type 2 diabetes...
  81. ncbi Overproduction of angiotensinogen from adipose tissue induces adipose inflammation, glucose intolerance, and insulin resistance
    Nishan S Kalupahana
    Obesity Research Center, University of Tennessee UT, Knoxville, Tennessee, USA
    Obesity (Silver Spring) 20:48-56. 2012
    ..Male aP2-Agt mice exhibited glucose intolerance, insulin resistance, and lower insulin-stimulated glucose uptake by the skeletal muscle...
  82. ncbi Increased glucose excursion in cystic fibrosis and its association with a worse clinical status
    Myriam Costa
    Diabetes Research Group, CHUM Research Center Hôtel Dieu, Montreal QC, Canada H2W 1T7
    J Cyst Fibros 6:376-83. 2007
    ..The objectives are to investigate (a) the relative contribution of insulinopenia and insulin resistance (IR) for glucose tolerance and (b) the association between various glucose parameters and CF clinical status...
  83. ncbi Temporal and dietary fat content-dependent islet adaptation to high-fat feeding-induced glucose intolerance in mice
    Maria Sörhede Winzell
    Department of Clinical Sciences, Medicine, Lund University, SE 22184, Lund, Sweden
    Metabolism 56:122-8. 2007
    The high fat-fed mouse is an experimental model for studies of islet dysfunction as a mechanism for glucose intolerance and for evaluation of therapeutic targets...
  84. pmc Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes
    Diego Ize-Ludlow
    Department of Pediatrics, Division of Pediatric Endocrinology, Diabetes and Metabolism, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes 60:2086-91. 2011
    ..A progressive decline in insulin responses to glucose was noted in individuals before the onset of type 1 diabetes. We determined whether such abnormalities occurred in prediabetic NOD mice-the prototypic model for human type 1 diabetes...
  85. ncbi Glucose intolerance and 23-year risk of coronary heart disease and total mortality: the Honolulu Heart Program
    B L Rodriguez
    Department of Medicine, University of Hawaii at Manoa, USA
    Diabetes Care 22:1262-5. 1999
    The associations between glucose intolerance measured at the study entry date and the 23-year incidence of coronary heart disease (CHD), CHD mortality, and total mortality were examined at the Honolulu Heart Program.
  86. ncbi Evaluation of peripheral and autonomic neuropathy among patients with newly diagnosed impaired glucose tolerance
    Baris Isak
    Marmara University, Department of Neurology, Istanbul, Turkey
    Diabetes Metab Res Rev 24:563-9. 2008
    ....
  87. ncbi Adipose tissue-targeted 11β-hydroxysteroid dehydrogenase type 1 inhibitor protects against diet-induced obesity
    Juan Liu
    Department of Geratology, The First Hospital Affiliated to Nanjing Medical University, Nanjing, P R China
    Endocr J 58:199-209. 2011
    ..These results suggest that an adipose tissue-targeted pharmacological inhibitor of 11β-HSD1 may prove to be a new approach for the treatment of obesity and metabolic syndrome...
  88. pmc Unrecognized glucose intolerance is common in pulmonary arterial hypertension
    Meredith E Pugh
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
    J Heart Lung Transplant 30:904-11. 2011
    ..We aimed to define the prevalence of elevated HbA(1c) in PAH patients and to correlate HbA(1c) levels with functional assessment...
  89. ncbi Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes
    M Fukushima
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Metabolism 53:831-5. 2004
    To evaluate the factors causing glucose intolerance in type 2 diabetes in Japan, insulin secretion and insulin sensitivity were compared across the range of glucose tolerance...
  90. ncbi Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis
    Robert C Cooksey
    Division of Endocrinology, University of Utah School of Medicine, 30 North 2030 East, Salt Lake City, Utah 84132
    Endocrinology 145:5305-12. 2004
    ..This abnormality alone, however, is insufficient to cause diabetes...
  91. ncbi Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet
    Wei Zhang
    Xiamen Diabetes Institute, 55 Zhen Hai Road, Xiamen 361003, PR China
    Eur J Pharmacol 649:398-402. 2010
    ..Collectively, we revealed that puerarin could improve body weight gain, glucose/insulin intolerance and adipokine expression in HFD-induced insulin resistant rats, indicating its potential value for treatment of metabolic syndrome...
  92. pmc Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance
    Mia C Akerfeldt
    Diabetes and Obesity Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Diabetes 60:2506-14. 2011
    ..Increased expression of the helix-loop-helix protein Id1 has been found in islets of diabetic mice and in vitro models of β-cell dysfunction. Here, we investigated the role of Id1 in insulin secretion and glucose homeostasis...
  93. ncbi Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians
    Harvest F Gu
    Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Diabetes 53:S31-5. 2004
    ..The present study provides additional evidence that SNPs in the proximal promoter region of the APM1 gene contribute to the development of type 2 diabetes...
  94. ncbi Fish oil and argan oil intake differently modulate insulin resistance and glucose intolerance in a rat model of dietary-induced obesity
    Samira Samane
    Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
    Metabolism 58:909-19. 2009
    ..together, these results strongly support the beneficial action of FO on diet-induced insulin resistance and glucose intolerance, an effect likely explained by the ability of FO to prevent HFHS-induced adiposity...
  95. ncbi Abdominal obesity and the prevalence of diabetes and intermediate hyperglycaemia in Chinese adults
    Yuna He
    National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 10050, People s Republic of China
    Public Health Nutr 12:1078-84. 2009
    ..To assess the association of indicators of general and abdominal obesity with the prevalence of type 2 diabetes (T2DM) and intermediate hyperglycaemia (IHG) in the Chinese population...
  96. pmc SirT1 gain of function increases energy efficiency and prevents diabetes in mice
    Alexander S Banks
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 8:333-41. 2008
    ..These findings have important implications for Sirtuin-based therapies in humans...
  97. ncbi Postnatal programming of glucocorticoid metabolism in rats modulates high-fat diet-induced regulation of visceral adipose tissue glucocorticoid exposure and sensitivity and adiponectin and proinflammatory adipokines gene expression in adulthood
    Sandrine Boullu-Ciocca
    INSERM U626, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Diabetes 57:669-77. 2008
    ..We hypothesized that postnatal programming could modulate high-fat diet-induced adipose tissue dysregulation in adulthood...
  98. pmc Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth
    Jake A Kushner
    Division of Endocrinology, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:3752-62. 2005
    ..proliferation, adult mass, and glucose tolerance were decreased in adult cyclin D2(-/-) mice, causing glucose intolerance that progressed to diabetes by 12 months of age...
  99. ncbi Impact of 3-year lifestyle intervention on postprandial glucose metabolism: the SLIM study
    C Roumen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabet Med 25:597-605. 2008
    ....
  100. ncbi Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes
    Kwan Yi Chu
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories
    Diabetes 55:367-74. 2006
    ..Oral losartan treatment delayed the onset of diabetes, and reduced hyperglycemia and glucose intolerance in db/db mice, but did not affect the insulin sensitivity of peripheral tissues...
  101. ncbi Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology
    D O'Regan
    Endocrinology Unit, Molecular Medicine Centre, School of Molecular and Clinical Medicine, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Am J Physiol Endocrinol Metab 287:E863-70. 2004
    ....

Research Grants75

  1. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..The primary goal of this proposal is to reduce hypertension and at the same time minimize hyperglycemia and glucose intolerance associated with insulin resistance...
  2. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..Numerous studies have also shown a robust association between OSA and insulin resistance, glucose intolerance and the risk of diabetes, independently of body mass index...
  3. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..injury (SCI) are at a lifelong risk of increasing obesity and several chronic metabolic disorders such as glucose intolerance, insulin resistance and dyslipidemia secondary to deterioration in body composition...
  4. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..If such studies are borne out, the ramifications are huge, with profound implications for understanding, evaluating and treating atherosclerotic disease - the number one killer of adult human beings in the western hemisphere. ..
  5. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..blood pressure (BP)and vascular and pressure- sensitive target organ injury, weight gain, dyslipidemia, and glucose intolerance. We propose a study in ~ 65 healthy, normotensive African Americans enrolled in the NIH-funded ONOSS study ..
  6. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..Intriguing observations suggest that endogenous sex hormones (ESH) may contribute to glucose intolerance in postmenopausal women...
  7. Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
    Robert V Farese; Fiscal Year: 2013
    ..Despite these signaling defects, aside from mild glucose intolerance and hyperinsulinemia, Het-TBlambda KO mice do not develop MS or T2DM...
  8. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..insulin signaling and 2) the role of chronic psychological stress in the development of glucose intolerance and insulin resistance and determine whether these responses are involved in the modulation of ..
  9. Hormonal regulation of a Ca2+/AMPK signaling pathway
    Anthony R Means; Fiscal Year: 2013
    ..Mice null for CaMKK2 are protected from the insulin resistance, glucose intolerance, obesity and liver steatosis that result from consuming a high fat diet...
  10. Metabolic impact of fructose restriction in obese children
    Jean Marc Schwarz; Fiscal Year: 2013
    ..NAFLD);African American children present instead with hypertension, worsened insulin resistance, and glucose intolerance. Understanding these variations in presentation of metabolic syndrome holds the key to understanding its ..
  11. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
    ..is epidemic, more insight into the physiology of body weight regulation including how obesity relates to glucose intolerance is needed...
  12. Novel pathways for fat burning that protects from high fat diet-induced metabolic
    Sihem Boudina; Fiscal Year: 2013
    ..specific MnSOD KO (AdSod2KO) mice are lean, have increased whole body fat oxidation and resist diet-induced glucose intolerance, insulin resistance and hepatic steatosis...
  13. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation
    Xianxin Hua; Fiscal Year: 2013
    ..Our new results since the last submission also demonstrate that acute Men1 excision normalized pre-existing glucose intolerance in high-fat diet-fed mice...
  14. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    ..However, diet-induced obese AOiGHD mice developed glucose intolerance which was associated with low fed and fasted insulin levels, suggesting GH/IGF-I may also be important in ..
  15. Interaction of fetal growth and bisphenol A in obesity
    Frederick S vom Saal; Fiscal Year: 2013
    ..Adult IUGR mice show marked similarities to IUGR humans in terms of glucose intolerance, elevated insulin as well as an increase in total abdominal fat weight, but have markedly fewer gonadal fat ..
  16. The Impact of Heat Shock Protein Expression on Inflammation and Insulin Action
    Andrea L Hevener; Fiscal Year: 2013
    ..we now provide evidence in this revised application that ablation of HSP72 causes JNK activation, glucose intolerance, insulin resistance and increased adiposity...
  17. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
    ..Preliminary studies show that offspring delivered from estrogen-deprived baboon pregnancies exhibit glucose intolerance/insulin resistance...
  18. INSULIN ACTION IN MUSCLE AND FAT CELLS
    JAMES CARLTON GARRISON; Fiscal Year: 2010
    ..Lpn1fld/fld mice exhibit fatty liver, defective adipogenesis, glucose intolerance and insulin resistance...
  19. Thyroid-adrenergic synergism and adaptive thermogenesis
    Antonio C Bianco; Fiscal Year: 2013
    ..that the D2KO mouse develops a striking metabolic phenotype, including obesity, marked hepatic steatosis, glucose intolerance and insulin resistance...
  20. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation.
    Xianxin Hua; Fiscal Year: 2010
    ..Our new results since the last submission also demonstrate that acute Men1 excision normalized pre-existing glucose intolerance in high-fat diet-fed mice...
  21. Post-Developmental Adipocyte Autophagy in Control of Insulin-Glucose Homeostasis
    Timothy E Graham; Fiscal Year: 2013
    ..mice were lean and protected from diet-induced obesity, and exhibited enhanced insulin sensitivity and glucose intolerance. Such observations led to speculations that inhibiting autophagy in adipocytes might provide a promising ..
  22. Epigenomic regulation of metabolism in muscle by circadian clock and environment
    Zheng Sun; Fiscal Year: 2013
    ..muscle, and have found that the mice display disrupted metabolic circadian gene expression and exacerbated glucose intolerance that is induced by high fat diet (HFD)...
  23. A Clinical Trial to Prevent New Onset Diabetes After Transplantation
    Akinlolu O Ojo; Fiscal Year: 2013
    ..recipients (KTRs) will manifest persistent reversible hyperglycemia, 30% will maintain chronic impaired glucose intolerance and 15-20% will succumb to new onset diabetes after transplantation (NODAT) by the end of the first post ..
  24. Human Cell-Based Models of Primary Adipocyte Disorders
    CHAD ALBERT COWAN; Fiscal Year: 2013
    ..Due to the loss of adipose, patients exhibit metabolic dysfunction such as insulin resistance, glucose intolerance, lowered plasma high-density-lipoprotein cholesterol, and accumulation of plasma triglycerides...
  25. Activation of Atypical PKC by Insulin and Other Agonists
    ROBERT VITO FARESE; Fiscal Year: 2013
    ..multiple O/MS and T2DM models elicits rapid and dramatic improvements in hepatosteatosis, hyperlipidemia, glucose intolerance, hyperinsulinemia, and insulin signaling in muscle and liver;also, as an added benefit, inhibition of ..
  26. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..The knowledge gained from the proposed experiments will help lead to the development of new therapeutic approaches to the treatment of glucose intolerance and diabetes.
  27. Early Pathogenesis of Cystic Fibrosis Related Diabetes
    Andrew W Norris; Fiscal Year: 2013
    ..pancreatic disease as seen in human CF patients, including early glycemic abnormalities and progression to glucose intolerance. This CF ferret model, in conjunction with human studies in CF infants and children, will be used by this ..
  28. Structure-Based Design of Novel HNF4a Antagonists to Treat Metabolic Syndrome
    Arnold T Hagler; Fiscal Year: 2010
    ..e. hypertriglyceridemia and low HDL levels), glucose intolerance, and obesity...
  29. Restorative Yoga for Therapy of the Metabolic Syndrome (RHYTHMS) study
    Alka M Kanaya; Fiscal Year: 2012
    ..primary outcome) and improves features of the metabolic syndrome: insulin resistance, hypertension, glucose intolerance, and dyslipidemia (secondary outcomes) compared to a stretching control group after a 24-week intervention ..
  30. Hypothalamic autophagy and metabolic regulation in aging
    Rajat Singh; Fiscal Year: 2013
    ..rodents lacking MA in hypothalamic POMC neurons display reduced [unreadable]-MSH, increased adiposity and glucose intolerance. Decreased MA activity has been described in different organs in old organisms, and we have now ..
  31. Control of cAMP Mediated Glucagon Response by Bile Acids
    Norman H Lee; Fiscal Year: 2011
    ..Around 50% of patients with liver disease and 80% of cirrhotic patients display glucose intolerance associated with a decreased gluconeogenic response to glucagon...
  32. The Role of Nuclear Receptor PPARbeta in the Regulation of Muscle Fuel Metabolism
    EMILY YVONNE SMITH; Fiscal Year: 2013
    ..insulin resistant state, displaying myocyte triglyceride accumulation, high fatty acid oxidation rates, glucose intolerance and decreased exercise capacity...
  33. Pharmacogenomics of CVD risk Reduction
    ALAN SHULDINER; Fiscal Year: 2009
    ..causative role in the metabolic syndrome, a constellation of CVD risk factors that include central obesity, glucose intolerance, hypertension, and hyperlipidemia. TZDs (e.g...
  34. Nutrition and Nonalcoholic Fatty Liver Disease
    Zhiping Li; Fiscal Year: 2012
    ..elements of the metabolic syndrome, a clinical constellation of obesity, hypertension, insulin resistance, glucose intolerance and hyperlipidemia...
  35. Function and Regulation of Islet-associated Macrophages in Obesity and Diabetes
    David L Morris; Fiscal Year: 2013
    ..little is known about whether and how islet-associated macrophages contribute to islet inflammation, glucose intolerance, and beta cell dysfunction in T2DM...
  36. Time-of-Day-Dependent Feeding Influences Myocardial Function
    MARTIN ELLIOT YOUNG; Fiscal Year: 2012
    ..at the end of the active/awake period develop a cardiometabolic syndrome phenotype (weight gain, adiposity, glucose intolerance, hyperinsulinemia, hypertriglyceridemia, and hyperleptinemia, compared to mice fed the same meal at the ..
  37. Regulation of Metabolism by the Hormone FGF15/19
    Steven A Kliewer; Fiscal Year: 2013
    ..models of metabolic disease, whereas knocking out FGF15 expression in mice results in hyperinsulinemia and glucose intolerance. Together, these findings have linked postprandial uptake of bile acids in the gut with a novel FGF ..
  38. Epidemiology & epigenetics: Maternal diet, DNA methylation, & offspring adiposity
    Matthew W Gillman; Fiscal Year: 2010
    ..adverse impact on markers of chronic cardio- metabolic disease like adiposity, blood pressure and glucose intolerance, and on lifespan itself...
  39. Hyperglycemia and adverse pregnancy outcome (HAPO)
    Boyd E Metzger; Fiscal Year: 2010
    ..On the other hand, the risk of adverse outcome associated with degrees of glucose intolerance less severe than overt DM is controversial...
  40. RBP4, Inflammation, and Insulin Resistance
    JULIE ELIZABETH NORSEEN; Fiscal Year: 2012
    ..Furthermore, elevating RBP4, either genetically or by injections, causes insulin resistance, glucose intolerance, and impaired insulin signaling in skeletal muscle of rodents...
  41. Long-Term Safety and Genetic Risk Factors of Risperdone Treatment in Youth
    Chadi A Calarge; Fiscal Year: 2010
    ..and result in metabolic abnormalities has generated calls to investigate the occurrence of dyslipidemia, glucose intolerance, insulin resistance, and the metabolic syndrome phenotype in youth treated with these potent drugs...
  42. Regulation of Adipose Tissue Inflammation and Insulin Resistance by T Cell Subset
    ERICA LYN STONE; Fiscal Year: 2013
    ..I propose to 1) investigate the role of T cell subsets in high fat diet -induced insuli resistance and glucose intolerance, 2) investigate the homing of T regulatory cells to the adipose tissue and, 3) Determine how obesity ..
  43. Stimulated by Retinoic Acid (STra6) in Energy Homeostasis
    LAURA H ZEMANY; Fiscal Year: 2013
    ..Injection of purified RBP4 in rodents causes insulin resistance, glucose intolerance, and impaired insulin signaling in skeletal muscle...
  44. Role of Group 1B Phospholipase A2 on Diet-induced Metabolic Diseases
    David Y Hui; Fiscal Year: 2013
    ..and as a consequence decreases hepatic fatty acid oxidation in protection against diet-induced obesity and glucose intolerance. This renewal application will delineate the mechanism by which intestinal lysoPL absorption suppresses ..
  45. Impact of Sleep in the Restoring Insulin Secretion (RISE) Study
    Babak Mokhlesi; Fiscal Year: 2013
    ..established a robust association between the presence and severity of OSA with both insulin resistance and glucose intolerance, independent of adiposity...
  46. Role of Adipose in Ethanol-Induced Tissue Injury
    Laura E Nagy; Fiscal Year: 2013
    ..Chronic, heavy ethanol exposure results in the development of glucose intolerance and hepatic insulin resistance...
  47. Tissue specific production of RBP4 and mechanism of insulin resistance
    Timothy E Graham; Fiscal Year: 2013
    ..the metabolic syndrome, and type 2 diabetes, and RBP4 plays a causal role in insulin resistance and glucose intolerance. RBP4 is the sole specific transport protein for Vitamin A (retinol) in blood...
  48. Periodontitis and pre-clinical diabetes
    CYNTHIA MADELINE PEREZ; Fiscal Year: 2013
    ..over a three-year period, individuals with periodontal disease at baseline have a higher increase in glucose intolerance and insulin resistance compared to those without periodontal disease;(2) to determine if the longitudinal ..
  49. Mechanisms Linking Sleep-Disordered Breathing and Cardiovascular Disease
    Larissa A Shimoda; Fiscal Year: 2010
    ..of signaling pathways including endothelin-1 (ET-1) and increasing the propensity for insulin resistance, glucose intolerance and type 2 diabetes...
  50. Type 2 Diabetes Risk in Women With Gestational Diabetes
    Catherine Kim; Fiscal Year: 2010
    ..amp;Gynecology, and she is interested in a research career improving the quality of care for women with glucose intolerance. Sponsor and Environment: William Herman, M.D. M.P.H...
  51. Discovery of an Osteocalcin Sensing GPCR Regulating Beta-Cell Function
    L Darryl Quarles; Fiscal Year: 2013
    ..ablation of GPRC6A to create OcnR-/- mice results in a phenotype that resembles Ocn-/- mice, including glucose intolerance, reductions in circulating insulin levels, and insulin resistance...
  52. Lactation and Glucose Tolerance After GDM Pregnancy
    ERICA PAULINE GUNDERSON; Fiscal Year: 2011
    ..Development of glucose intolerance during pregnancy, known as gestational diabetes (GDM), is a strong predictor of subsequent development of ..
  53. Exercise Regulation of Glucose Homeostasis
    Laurie J Goodyear; Fiscal Year: 2013
    ..generated during this funding cycle have shown that maternal exercise can abolish the development of glucose intolerance, increased fasting insulin concentrations, insulin resistance, and increased body fat in offspring at one ..
  54. The Role of Visceral Fatty Acids in Relation to Insulin Resistance
    Michelle T Foster; Fiscal Year: 2013
    ..We propose to test the hypothesis that insulin resistance/glucose intolerance can be reversed by procedures that promote adipocyte expansion and FA retention in the visceral bed...
  55. GENETICS OF DIABETES IN THE AMISH
    ALAN SHULDINER; Fiscal Year: 2009
    ..that Nos1ap knockout (KO) mice will have increased propensity for weight gain, altered insulin secretion, glucose intolerance/diabetes, and hyperlipidemia compared to its wild type littermates...
  56. Cardioprotective Efficacy ofMg-Supplementation during HAART Therapy
    IVAN TONG MAK; Fiscal Year: 2011
    ..HAART-induced metabolic effects will be assessed (glucose intolerance, plasma lipid disturbances), and immunohistochemical and pathology techniques will be used to localize ..
  57. Hepatic Estrogen Signaling and Protection Against Insulin Resistance
    MELISSA NICOLE MARTINEZ; Fiscal Year: 2013
    ..In our third AIM, we determine if genetic inactivation of FoxO1 can prevent glucose intolerance caused by high-fat feeding after surgical menopause by ovariectomy...
  58. Mechanisms of Altered Glucose Metabolism in Sleep-Disordered Breathing
    Naresh Punjabi; Fiscal Year: 2013
    ..is an emerging concept in the literature that SDB is independently associated with insulin resistance, glucose intolerance, and type 2 diabetes mellitus...
  59. Hepatocyte Growth Factor and the Pancreatic Beta Cell
    Adolfo Garcia-Ocana; Fiscal Year: 2013
    ..gluco-lipotoxicity-induced apoptosis;and, (iv) transgenic mice overexpressing p53 in the beta cell display glucose intolerance. Importantly, a recent comprehensive association study of obesity/type 2 diabetes and related quantitative ..
  60. A Transgenerational e-Intervention for Gestational Diabetics and their Offspring
    Wanda K Nicholson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gestational diabetes, defined as glucose intolerance that first occurs or is first identified in pregnancy, is part of a vicious cycle that contributes o the epidemic of diabetes and obesity across ..
  61. Effects of 2wk fructose &HFCS consumption on lipid dysregulation &insulin resis
    Peter J Havel; Fiscal Year: 2012
    ..provide evidence that consumption of fructose promotes the development of an atherogenic lipid profile and glucose intolerance/insulin resistance within 2 weeks, while glucose consumption does not...
  62. Fat Oxidation, Redox Stress and Insulin Resistance in Skeletal Muscle
    KARI WONG; Fiscal Year: 2013
    ..A prominent theory asserts that diminished mitochondrial fat oxidation causes glucose intolerance due do an accumulation of intramuscular lipids...
  63. NEIGHBORHOOD CHARACTERISTICS AND RISK OF GESTATIONAL DIABETES IN NEW YORK CITY
    Teresa Janevic; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The incidence of gestational diabetes, characterized as glucose intolerance with onset during pregnancy, is increasing...
  64. Leptin modulation of insulin action in the islet b-cell
    Rohit Kulkarni; Fiscal Year: 2005
    ..of the insulin or IGF-1 receptors manifest defects in glucose-stimulated insulin secretion and develop glucose intolerance, but surprisingly do not show alterations in the growth and development of the beta-cell/islets...
  65. MECHANISMS OF ACTION IN DPP INTERVENTIONS
    Abbas Kitabchi; Fiscal Year: 2001
    ..is an ancillary study to the DPP to investigate the mechanisms by which the three interventions affect glucose intolerance and insulin resistance...
  66. Angiogenesis in a model of diabetes and endothelial dysfunction
    Frank Sellke; Fiscal Year: 2009
    Over 35 million people in the United States are affected by diabetes and glucose intolerance. These individuals carry up to eight times the risk of cardiovascular events compared to non-diabetic individuals, making cardiovascular ..
  67. ENDOCRINE AND NUTRITIONAL FACTORS IN OBESITY
    LARYSSA KAUFMAN; Fiscal Year: 1990
    Obesity, glucose intolerance, hyperinsulinemia and insulin resistance are attributes of the genetically obese (ob/ob) mouse which make it particularly suitable as a model for human obesity and noninsulin-dependent diabetes...
  68. RBP4-Transthyretin Interactions in Insulin Resistant States
    TIMOTHY EUGENE GRAHAM; Fiscal Year: 2009
    ..In a series of animal models we demonstrated that increasing serum RBP4 causes insulin resistance and glucose intolerance, whereas lowering serum RBP4 improves insulin sensitivity and glucose tolerance...
  69. Serum Sex Hormones and Cardiovascular Risk in the MACS
    Adrian Dobs; Fiscal Year: 2009
    ..Low serum T may be a risk factor for CVD through increased visceral adiposity (leading to glucose intolerance, diabetes mellitus), inflammation or a more direct effect on the vasculature...
  70. NORMAL AGING AND DIABETES--METABOLIC DISTINCTION
    RODWIN JACKSON; Fiscal Year: 1993
    ..Further understanding is essential, however, for the formulation of a rational approach to the glucose intolerance of ageing...
  71. Xanthohumol and Metabolic Syndrome
    Jan Frederik Stevens; Fiscal Year: 2012
    ..Risk factors that contribute to MetS include atherogenic dyslipidemia and glucose intolerance. Many genes involved in dyslipidemia and glucose metabolism are regulated by modulation of the farnesoid X ..
  72. Role of Adipose in Ethanol-Induced Tissue Injury
    Laura Nagy; Fiscal Year: 2009
    ..Chronic, heavy ethanol exposure results in the development of glucose intolerance and hepatic insulin resistance...
  73. JAPANESE AMERICAN COMMUNITY DIABETES STUDY
    Wilfred Fujimoto; Fiscal Year: 1990
    ..In turn, hyperinsulinemia and glucose intolerance appear to lead to atherosclerosis, while hyperglycemia is a risk for development of microangiopathy and ..
  74. The impact of PPAR-gamma and estrogen receptor crosstalk on insulin action
    Andrea Hevener; Fiscal Year: 2007
    ..We have previously shown that selective skeletal muscle PPAR-g deletion (MKO) causes glucose intolerance and severe insulin resistance in young and aged male mice...
  75. CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY
    John Gottdiener; Fiscal Year: 2001
    ..population and suspected risk factors are examined and include hypercholesterolemia, hypertension, glucose intolerance and diabetes, and cigarette smoking...