hyperglycemia

Summary

Summary: Abnormally high BLOOD GLUCOSE level, beyond the normal range (roughly 70 to 150 mg/100 ml of PLASMA).

Top Publications

  1. ncbi Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress
    Anabela P Rolo
    Center for Neurosciences and Cell Biology of Coimbra, Department of Zoology, University of Coimbra, 3004 517 Coimbra, Portugal
    Toxicol Appl Pharmacol 212:167-78. 2006
  2. ncbi Hyperglycemia-induced oxidative stress in diabetic complications
    George L King
    Section on Vascular Cell Biology and Complications, Joslin Diabetes Center, Boston, Massachusetts, USA
    Histochem Cell Biol 122:333-8. 2004
  3. pmc Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    Silvio E Inzucchi
    Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 35:1364-79. 2012
  4. ncbi Biochemistry and molecular cell biology of diabetic complications
    M Brownlee
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nature 414:813-20. 2001
  5. ncbi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
  6. ncbi The pathobiology of diabetic complications: a unifying mechanism
    Michael Brownlee
    Departments of Medicine and Pathology, Albert Einstein College of Medicine, F 531 1300 Morris Park Ave, Bronx, NY 10461 1602, USA
    Diabetes 54:1615-25. 2005
  7. pmc Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:193-203. 2009
  8. ncbi Diabetes and atherosclerosis: epidemiology, pathophysiology, and management
    Joshua A Beckman
    Leducq Center for Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    JAMA 287:2570-81. 2002
  9. ncbi Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
    Louis Monnier
    Department of Metabolic Diseases, Lapeyronie Hospital, University of Montpellier, Montpellier, France
    JAMA 295:1681-7. 2006
  10. pmc Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    Kathrin Maedler
    Division of Endocrinology and Diabetes, University Hospital, Zurich, Switzerland
    J Clin Invest 110:851-60. 2002

Detail Information

Publications386 found, 100 shown here

  1. ncbi Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress
    Anabela P Rolo
    Center for Neurosciences and Cell Biology of Coimbra, Department of Zoology, University of Coimbra, 3004 517 Coimbra, Portugal
    Toxicol Appl Pharmacol 212:167-78. 2006
    b>Hyperglycemia resulting from uncontrolled glucose regulation is widely recognized as the causal link between diabetes and diabetic complications...
  2. ncbi Hyperglycemia-induced oxidative stress in diabetic complications
    George L King
    Section on Vascular Cell Biology and Complications, Joslin Diabetes Center, Boston, Massachusetts, USA
    Histochem Cell Biol 122:333-8. 2004
    Reactive oxygen species are increased by hyperglycemia. Hyperglycemia, which occurs during diabetes (both type 1 and type 2) and, to a lesser extent, during insulin resistance, causes oxidative stress...
  3. pmc Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    Silvio E Inzucchi
    Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 35:1364-79. 2012
  4. ncbi Biochemistry and molecular cell biology of diabetic complications
    M Brownlee
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Nature 414:813-20. 2001
    ..This integrating paradigm provides a new conceptual framework for future research and drug discovery...
  5. ncbi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
    It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus is associated with increased risks of adverse pregnancy outcomes.
  6. ncbi The pathobiology of diabetic complications: a unifying mechanism
    Michael Brownlee
    Departments of Medicine and Pathology, Albert Einstein College of Medicine, F 531 1300 Morris Park Ave, Bronx, NY 10461 1602, USA
    Diabetes 54:1615-25. 2005
  7. pmc Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    David M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:193-203. 2009
    ..In this revision, we focus on the new classes of medications that now have more clinical data and experience...
  8. ncbi Diabetes and atherosclerosis: epidemiology, pathophysiology, and management
    Joshua A Beckman
    Leducq Center for Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    JAMA 287:2570-81. 2002
    ..Complications of atherosclerosis cause most morbidity and mortality in patients with diabetes mellitus. Despite the frequency and severity of disease, proven medical therapy remains incompletely understood and underused...
  9. ncbi Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
    Louis Monnier
    Department of Metabolic Diseases, Lapeyronie Hospital, University of Montpellier, Montpellier, France
    JAMA 295:1681-7. 2006
    ..Glycemic disorders, one of the main risk factors for cardiovascular disease, are associated with activation of oxidative stress...
  10. pmc Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    Kathrin Maedler
    Division of Endocrinology and Diabetes, University Hospital, Zurich, Switzerland
    J Clin Invest 110:851-60. 2002
    In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic beta cells, causing impaired insulin secretion. IL-1beta is a proinflammatory cytokine acting during the autoimmune process of type 1 diabetes...
  11. ncbi Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
    Joseph L Evans
    University of California at San Francisco, San Francisco, California 94143, USA
    Endocr Rev 23:599-622. 2002
    ..Thus, we propose a unifying hypothesis whereby hyperglycemia and FFA-induced activation of the nuclear factor-kappaB, p38 MAPK, and NH2-terminal Jun kinases/stress-..
  12. ncbi Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia
    Teresa A Hillier
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Diabetes Care 30:2287-92. 2007
    ..The purpose of this study was to determine how the range of measured maternal glycemia in pregnancy relates to risk of obesity in childhood...
  13. pmc Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
    Rui Hong Wang
    Genetics of Development and Disease Branch, NIH, 10 9N105, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Clin Invest 121:4477-90. 2011
    ..Liver-specific Sirt1 deficiency caused hepatic glucose overproduction, chronic hyperglycemia, and increased ROS production...
  14. pmc The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center at Medical City, Dallas, Texas, USA
    Diabetes Care 33:1516-22. 2010
    ..The efficacy and safety of the 11betaHSD1 inhibitor INCB13739 were assessed when added to ongoing metformin monotherapy in patients with type 2 diabetes exhibiting inadequate glycemic control (A1C 7-11%)...
  15. ncbi Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    D M Nathan
    Diabetes Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetologia 52:17-30. 2009
    ..In this revision, we focus on the new classes of medications that now have more clinical data and experience...
  16. ncbi Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline
    Guillermo E Umpierrez
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 97:16-38. 2012
    The aim was to formulate practice guidelines on the management of hyperglycemia in hospitalized patients in the non-critical care setting.
  17. pmc Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function
    Kunihiro Suzuki
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 108:13829-34. 2011
    ..Exposure of bEnd3 microvascular endothelial cells to elevated extracellular glucose (in vitro "hyperglycemia") induced the mitochondrial formation of reactive oxygen species (ROS), which resulted in an increased ..
  18. pmc The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes
    Patrick M Catalano
    Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio, USA
    Diabetes Care 35:780-6. 2012
    To determine associations of gestational diabetes mellitus (GDM) and obesity with adverse pregnancy outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study.
  19. pmc Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study
    David A Sacks
    Department of Obstetrics and Gynecology, Kaiser Foundation Hospital, Bellflower, California, USA
    Diabetes Care 35:526-8. 2012
    To report frequencies of gestational diabetes mellitus (GDM) among the 15 centers that participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study using the new International Association of the Diabetes and Pregnancy ..
  20. ncbi The Ins2Akita mouse as a model of early retinal complications in diabetes
    Alistair J Barber
    Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA
    Invest Ophthalmol Vis Sci 46:2210-8. 2005
    ..Male mice heterozygous for this mutation have progressive loss of beta-cell function, decreased pancreatic beta-cell density, and significant hyperglycemia, as early as 4 weeks of age.
  21. pmc Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
    X L Du
    Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Invest 108:1341-8. 2001
    ..Since hyperglycemia-induced mitochondrial superoxide overproduction increases O-linked N-acetylglucosamine modification and ..
  22. ncbi Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
    Yu Wang
    Genome Research Center and Department of Biochemistry, University of Hong Kong, Hong Kong, China
    Clin Chem 53:34-41. 2007
    ..Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies...
  23. ncbi Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, San Antonio, USA
    Endocr Rev 32:515-31. 2011
    b>Hyperglycemia plays an important role in the pathogenesis of type 2 diabetes mellitus, i.e., glucotoxicity, and it also is the major risk factor for microvascular complications...
  24. pmc 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress
    Y Kotelevtsev
    Centre for Genome Research, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH 9 3JQ, Scotland, UK
    Proc Natl Acad Sci U S A 94:14924-9. 1997
    ..The 11beta-HSD-1 -/- mice were found to resist hyperglycamia provoked by obesity or stress. Attenuation of hepatic 11beta-HSD-1 may provide a novel approach to the regulation of gluconeogenesis...
  25. ncbi Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)
    Louis Monnier
    Department of Metabolism, Lapeyronie Hospital, Montpellier, France
    Diabetes Care 26:881-5. 2003
    The exact contributions of postprandial and fasting glucose increments to overall hyperglycemia remain controversial. The discrepancies between the data published previously might be caused by the interference of several factors...
  26. pmc Insulin resistance, hyperglycemia, and atherosclerosis
    Karin E Bornfeldt
    Department of Pathology, Diabetes and Obesity Center of Excellence, 815 Mercer Street, University of Washington, Seattle, WA 98109, USA
    Cell Metab 14:575-85. 2011
    ..this area demand a thorough understanding of how two major features of type 2 diabetes, insulin resistance and hyperglycemia, impact atherosclerosis...
  27. pmc Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St Louis, Missouri 63110, USA
    Endocrinology 153:1039-48. 2012
    ..relative hyperglucagonemia, in the setting of deficient insulin secretion, plays a role in the pathogenesis of hyperglycemia in diabetes...
  28. ncbi Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
    Shuang Zhou
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, PR China
    Circ Res 109:639-48. 2011
    ..However, there is limited information about the negative regulating mechanisms of p66Shc expression in the vascular system...
  29. pmc Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006
    Catherine C Cowie
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 32:287-94. 2009
    ..S. during 2005-2006. We then compared the prevalences of these conditions with those in 1988-1994...
  30. pmc Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men
    Alena Stancakova
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Diabetes 61:1895-902. 2012
    We investigated the association of glycemia and 43 genetic risk variants for hyperglycemia/type 2 diabetes with amino acid levels in the population-based Metabolic Syndrome in Men (METSIM) Study, including 9,369 nondiabetic or newly ..
  31. ncbi Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    R Paul Robertson
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington 98122, USA
    Diabetes 53:S119-24. 2004
    ..The former theory posits hyperglycemia, an outcome of the disease, as a secondary force that further damages beta-cells...
  32. pmc Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Am J Physiol Heart Circ Physiol 300:H1133-40. 2011
    b>Hyperglycemia in diabetes mellitus promotes oxidative stress in endothelial cells, which contributes to development of cardiovascular diseases...
  33. pmc Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells
    Zaida Alipio
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    Proc Natl Acad Sci U S A 107:13426-31. 2010
    ..Long-term correction of hyperglycemia was achieved, as determined by blood glucose and hemoglobin A1c levels...
  34. ncbi Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
    Joseph L Evans
    Medical Research Institute, San Francisco, California University of California at San Francisco, San Francisco, California 94107, USA
    Diabetes 52:1-8. 2003
    ..Therefore, we propose here that the hyperglycemia-induced, and possibly FFA-induced, activation of stress pathways plays a key role in the development of not ..
  35. ncbi Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I
    Mark A Creager
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:1527-32. 2003
  36. ncbi Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes
    Jonathan P Little
    Dept of Kinesiology, McMaster University, Hamilton, Canada
    J Appl Physiol (1985) 111:1554-60. 2011
    ..05). Our findings indicate that low-volume HIT can rapidly improve glucose control and induce adaptations in skeletal muscle that are linked to improved metabolic health in patients with type 2 diabetes...
  37. ncbi Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling
    P Palsamy
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600 025 Tamilnadu, India
    Biochim Biophys Acta 1812:719-31. 2011
    b>Hyperglycemia-mediated oxidative stress plays a crucial role in the progression of diabetic nephropathy...
  38. ncbi Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
    Hye Seung Jung
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam ku, Seoul 135 710, Korea
    Cell Metab 8:318-24. 2008
    ..suggest that autophagy is necessary to maintain structure, mass and function of pancreatic beta cells, and its impairment causes insulin deficiency and hyperglycemia because of abnormal turnover and function of cellular organelles.
  39. ncbi Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives
    Sally A Madsen-Bouterse
    K 404, Kresge Eye Institute, Wayne State University, 4717 St Antoine, Detroit, MI, 48201, USA
    Rev Endocr Metab Disord 9:315-27. 2008
    ..Although antioxidants are being used for other chronic diseases, controlled clinical trials are warranted to investigate potential beneficial effects of antioxidants in the development of retinopathy in diabetic patients...
  40. ncbi Type 2 diabetes: principles of pathogenesis and therapy
    Michael Stumvoll
    Third Medical Department, University of Leipzig, Leipzig, Germany
    Lancet 365:1333-46. 2005
    ..Management includes not only diet and exercise, but also combinations of anti-hyperglycaemic drug treatment with lipid-lowering, antihypertensive, and anti platelet therapy...
  41. pmc Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study
    James W Albers
    Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diabetes Care 33:1090-6. 2010
    ....
  42. pmc Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands
    Dachun Yao
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 59:249-55. 2010
    ..Since hyperglycemia-induced reactive oxygen species (ROS) activate many pathways of diabetic tissue damage, the effect of these ..
  43. ncbi High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia
    Tine D Clausen
    Department of Obstetrics, Copenhagen Center for Pregnant Women with Diabetes, Copenhagen University Hospital, Rigshospitalet, Denmark
    Diabetes Care 31:340-6. 2008
    The role of intrauterine hyperglycemia and future risk of type 2 diabetes in human offspring is debated...
  44. ncbi Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice
    Masahito Takikawa
    College of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi 487 8501, Japan
    J Nutr 140:527-33. 2010
    ..In this study, we tested the effect of dietary bilberry extract (BBE) on hyperglycemia and insulin sensitivity in type 2 diabetic mice...
  45. ncbi Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in norma
    Garth J S Cooper
    School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand
    Diabetes 54:1468-76. 2005
    ..We suggest that cardiovascular complications in diabetes might be better controlled by therapeutic strategies that focus on lowering plasma glucose and loosely bound systemic Cu(II)...
  46. ncbi Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Am Coll Cardiol 55:1310-7. 2010
    ..Our objective was to estimate the magnitude of the relative risk (RR) for cardiovascular disease associated with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) from published prospective observational studies...
  47. pmc Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells
    Junyu Ning
    Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599, USA
    Endocrinology 152:3143-54. 2011
    ..The results suggest that AMPK plays an inhibitory role in modulating IGF-I-stimulated protein synthesis and that IGF-I must down-regulate AMPK activity to induce an optimal anabolic response...
  48. pmc Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
    Pedro Geraldes
    Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Boston, Massachusetts, USA
    Nat Med 15:1298-306. 2009
    Cellular apoptosis induced by hyperglycemia occurs in many vascular cells and is crucial for the initiation of diabetic pathologies...
  49. pmc Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetes
    Yimin Zhong
    Department of Medicine, Endocrinology, and Diabetes, Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Diabetes 61:492-504. 2012
    ..Taken together, our data indicate that ER stress and ATF4 play a critical role in retinal inflammatory signaling and Müller cell-derived inflammatory cytokine production in diabetes...
  50. ncbi Hyperglycemia increases mitochondrial superoxide in retina and retinal cells
    Yunpeng Du
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106 4951, USA
    Free Radic Biol Med 35:1491-9. 2003
    ..that inhibit the development of diabetic retinopathy all inhibit superoxide production, raising a possibility that these therapies inhibit retinopathy in part by inhibiting a hyperglycemia-induced increase in superoxide production.
  51. ncbi Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice
    Seung Hong Lee
    Department of Marine Life Science, Jeju National University, Jeju 690 756, Republic of Korea
    Food Chem Toxicol 48:2633-7. 2010
    ..whether dieckol may inhibit α-glucosidase and alpha-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice...
  52. pmc Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    Diabetes 60:1608-16. 2011
    We investigated the effects of 34 genetic risk variants for hyperglycemia/type 2 diabetes on lipoprotein subclasses and particle composition in a large population-based cohort.
  53. pmc Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia
    Jonathan P German
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, N334, PO Box 358055, Seattle, Washington 98195, USA
    Endocrinology 152:394-404. 2011
    ..extending previous evidence that leptin infusion directly into the lateral cerebral ventricle ameliorates hyperglycemia in rats with streptozotocin-induced uncontrolled diabetes mellitus, we showed that the underlying mechanism is ..
  54. pmc IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    J A Ehses
    Division of Endocrinology, Diabetes, and Nutrition and Center for Integrated Human Physiology, University Hospital of Zurich, 8045 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:13998-4003. 2009
    ..In vivo, treatment of GK rats with IL-1Ra decreased hyperglycemia, reduced the proinsulin/insulin ratio, and improved insulin sensitivity...
  55. pmc Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    Kitt Falk Petersen
    Yale University School of Medicine, Department of Internal Medicine, 300 Cedar St, S263 TAC, P O Box 9812, New Haven, CT 06520 8020, USA
    Diabetes 54:603-8. 2005
    ..3%; P = 0.21). In conclusion, these data support the hypothesis that moderate weight loss normalizes fasting hyperglycemia in patients with poorly controlled type 2 diabetes by mobilizing a relatively small pool of IHL, which ..
  56. pmc Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
    Xueliang Du
    Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    J Clin Invest 112:1049-57. 2003
    In this report, we show that hyperglycemia-induced overproduction of superoxide by the mitochondrial electron transport chain activates the three major pathways of hyperglycemic damage found in aortic endothelial cells by inhibiting ..
  57. ncbi Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice
    Takanori Tsuda
    Research Center for Biomarkers of Preventive Medicine, Doshisha University, Imadegawa dori, Kamigyo ku, Kyoto 602 8580, Japan
    J Nutr 133:2125-30. 2003
    ..In contrast, the induction did not occur in the HF + PCC group. The HF diet induced hyperglycemia, hyperinsulinemia and hyperleptinemia. These perturbations were completely normalized in rats fed HF + PCC...
  58. ncbi Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels
    J R Kersten
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 280:H1744-50. 2001
    b>Hyperglycemia is an important predictor of cardiovascular mortality in patients with diabetes...
  59. ncbi Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes
    Antonio Cervera
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
    Am J Physiol Endocrinol Metab 294:E846-52. 2008
    ..splanchnic and peripheral glucose metabolism, and delayed gastric emptying to the attenuation of postprandial hyperglycemia during intravenous exenatide administration...
  60. pmc Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    James F List
    Global Clinical Research, Bristol Myers Squibb, Princeton, New Jersey, USA
    Diabetes Care 32:650-7. 2009
    ..of renal sodium-glucose cotransporter 2, allows an insulin-independent approach to improve type 2 diabetes hyperglycemia. In this multiple-dose study we evaluated the safety and efficacy of dapagliflozin in type 2 diabetic patients.
  61. pmc Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
    Tianzheng Yu
    Department of Anesthesiology, Mitochondrial Research Interest Group, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 604, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 103:2653-8. 2006
    Increased production of mitochondrial reactive oxygen species (ROS) by hyperglycemia is recognized as a major cause of the clinical complications associated with diabetes and obesity [Brownlee, M. (2001) Nature 414, 813-820]...
  62. ncbi Management of type 2 diabetes: new and future developments in treatment
    Abd A Tahrani
    Centre of Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
    Lancet 378:182-97. 2011
    ..Early proof of principle has been shown for compounds that enhance and partly mimic insulin action and replicate some effects of bariatric surgery...
  63. ncbi Use of intensive insulin therapy for the management of glycemic control in hospitalized patients: a clinical practice guideline from the American College of Physicians
    Amir Qaseem
    American College of Physicians, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 154:260-7. 2011
    ....
  64. ncbi Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients
    Judith Jacobi
    Indiana University Health Methodist Hospital, Indianapolis, IN, USA
    Crit Care Med 40:3251-76. 2012
    ..To evaluate the literature and identify important aspects of insulin therapy that facilitate safe and effective infusion therapy for a defined glycemic end point...
  65. pmc Hyperglycemia impairs proteasome function by methylglyoxal
    Markus A Queisser
    School of Medicine, Institute of Biochemistry, Justus Liebig University, Giessen, Germany
    Diabetes 59:670-8. 2010
    The ubiquitin-proteasome system is the main degradation machinery for intracellularly altered proteins. Hyperglycemia has been shown to increase intracellular levels of the reactive dicarbonyl methylglyoxal (MGO) in cells damaged by ..
  66. ncbi Dolphins as animal models for type 2 diabetes: sustained, post-prandial hyperglycemia and hyperinsulinemia
    Stephanie Venn-Watson
    National Marine Mammal Foundation, San Diego, CA 92106, USA
    Gen Comp Endocrinol 170:193-9. 2011
    ..Criteria for a true natural animal model include the presence of a fasting hyperglycemia, evidence of insulin resistance, and pathologies matching that reported in humans...
  67. pmc Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum
    Itamar Raz
    Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Diabetes Care 36:1779-88. 2013
    ..Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia management in type 2 diabetes...
  68. pmc Evidence that hyperglycemia after recovery from hypoglycemia worsens endothelial function and increases oxidative stress and inflammation in healthy control subjects and subjects with type 1 diabetes
    Antonio Ceriello
    Department of Endocrinology, Hospital Clinic de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Diabetes 61:2993-7. 2012
    ..with type 1 diabetes, recovery from a 2-h induced hypoglycemia was obtained by reaching normoglycemia or hyperglycemia for another 2 h and then maintaining normal glycemia for the following 6 h...
  69. pmc Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells
    Wenjian Wang
    Department of Medicine, Nephrology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 15:186-200. 2012
    ..However, the signaling pathways by which hyperglycemia leads to mitochondrial dysfunction are not fully understood...
  70. pmc Characterization of a mouse model of hyperglycemia and retinal neovascularization
    Elizabeth P Rakoczy
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, Australia
    Am J Pathol 177:2659-70. 2010
    ..To study how the two important factors--hyperglycemia and vascular endothelial growth factor--interact in diabetic retinopathy, the Akimba mouse (Ins2AkitaVEGF+/-) ..
  71. pmc PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia
    Ivo Quack
    Department of Nephrology, Heinrich Heine University, 40225 Duesseldorf, Germany
    J Biol Chem 286:12959-70. 2011
    ..In diabetes, hyperglycemia leads to the loss of surface expression of nephrin and causes albuminuria...
  72. ncbi Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity
    Wineke Bakker
    Laboratory of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Cell Tissue Res 335:165-89. 2009
    ..b>Hyperglycemia is a characteristic feature of type 1 and type 2 diabetes and plays a pivotal role in diabetes-associated ..
  73. ncbi Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling
    Jacob Raphael
    Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA
    J Cardiovasc Pharmacol 55:348-57. 2010
    b>Hyperglycemia is known to inhibit ischemic and anesthetic preconditioning...
  74. ncbi Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice
    Ryuichi Moriya
    Banyu Tsukuba Research Institute, Merck Research Laboratory, Tsukuba, Ibaraki, Japan
    Am J Physiol Endocrinol Metab 297:E1358-65. 2009
    ..Our findings indicate that SGLT1 serves as the intestinal glucose sensor for glucose-induced incretin secretion and that a noncalorigenic SGLT1 substrate ameliorates hyperglycemia by stimulating incretin secretion.
  75. ncbi Insulin resistance in critical illness
    Archana Dhar
    Division of Critical Care, Department of Pediatrics, Children s Medical Center, University of Texas Southwestern, Dallas, USA
    Curr Opin Pediatr 23:269-74. 2011
    ..Hence, a better understanding of these regulatory mechanisms and the alterations leading to dysfunction will set the basis for a better metabolic and immune support of critically ill patients...
  76. pmc Contributions of basal and postprandial hyperglycemia over a wide range of A1C levels before and after treatment intensification in type 2 diabetes
    Matthew Riddle
    Department of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon, USA
    Diabetes Care 34:2508-14. 2011
    To determine the relative contributions of basal hyperglycemia (BHG) versus postprandial hyperglycemia (PPHG) before and after treatment intensification in patients with glycated hemoglobin A(1c) (A1C) >7.0% while on prior oral therapy.
  77. pmc Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue
    Tim B Koenen
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Diabetes 60:517-24. 2011
    ..In this study, we set out to investigate whether hyperglycemia drives IL-1β production and caspase-1 activation in murine and human adipose tissue, thus inducing insulin ..
  78. pmc Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility
    Po Ming Ku
    Department of Medical Research, Chi Mei Medical Center, NO, 901 Chon Hwa Road, Yong Kang, Tainan City, Taiwan
    Cardiovasc Diabetol 10:57. 2011
    ..In recent studies, hyperglycemia-induced reactive oxygen species (ROS) in cardiomyocytes have been linked to diabetic cardiomyopathy...
  79. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
    ..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
  80. pmc Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:993-1004. 2009
    ..Administration of BALB/c-MSC temporarily resulted in reversal of hyperglycemia in 90% of NOD mice (p = 0.002). Transfer of autologous NOD-MSC imparted no such therapeutic benefit...
  81. pmc Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies
    Theodore Mazzone
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Lancet 371:1800-9. 2008
    ....
  82. ncbi Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus
    P Froguel
    Centre d Etude du Polymorphisme Humain, Paris, France
    N Engl J Med 328:697-702. 1993
    ....
  83. ncbi The role of protein kinase C activation and the vascular complications of diabetes
    Net Das Evcimen
    Ankara University, Pharmacy Faculty, Biochemistry Department, 06100 Ankara, Turkey
    Pharmacol Res 55:498-510. 2007
    ..Chronic hyperglycemia is a major initiator of diabetic micro- and cardiovascular complications, such as retinopathy, neuropathy and ..
  84. pmc Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Frederick, Maryland 20892, USA
    J Clin Invest 111:737-47. 2003
    ..These data indicate that hepatic PPARgamma plays a critical role in the regulation of TG content and in the homeostasis of blood glucose and insulin resistance in steatotic diabetic mice...
  85. ncbi The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia
    Finlay A McAlister
    2E3 24 WMC, University of Alberta Hospital, 8440 112 Street, Edmonton, Alberta, Canada T6G 2R7
    Diabetes Care 28:810-5. 2005
    To examine whether hyperglycemia at the time of presentation was associated with outcomes in patients admitted to non-intensive care settings with community-acquired pneumonia (CAP).
  86. pmc The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia
    Nadine S Sauter
    Larry L Hillblom Islet Research Center, University of California Los Angeles, Los Angeles, California 90095 7345, USA
    Endocrinology 149:2208-18. 2008
    ..Insulin mRNA was reduced in islets from mice fed a HFD but normalized in the IL-1Ra group. Our results show that IL-1Ra improves beta-cell survival and function, and support the potential role for IL-1Ra in the treatment of diabetes...
  87. ncbi A brain-liver circuit regulates glucose homeostasis
    Alessandro Pocai
    Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Metab 1:53-61. 2005
    Increased glucose production (GP) is the major determinant of fasting hyperglycemia in diabetes mellitus...
  88. ncbi Diabetes mellitus as a prothrombotic condition
    P J Grant
    Academic Unit of Molecular Vascular Medicine, Leeds Institute for Genetics, Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    J Intern Med 262:157-72. 2007
    ....
  89. pmc Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia
    James T Thackeray
    Molecular Function and Imaging Program, National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, K1Y 4W7, Canada
    Cardiovasc Diabetol 10:75. 2011
    ..We hypothesized that sustained hyperglycemia in the high fat diet-fed streptozotocin (STZ) rat model of sustained hyperglycemia with insulin resistance ..
  90. ncbi Beneficial effects of banana (Musa sp. var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced diabetic rats
    Jamuna J Bhaskar
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India
    J Physiol Biochem 67:415-25. 2011
    ..We have examined the effect of banana (Musa sp. var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced diabetic rats...
  91. pmc Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators
    Julia V Busik
    Department of Physiology, Michigan State University, East Lansing, Michigan, USA
    Diabetes 57:1952-65. 2008
    ..This study determined the effects of high glucose exposure and cytokine treatment on generation of reactive oxygen species (ROS) and activation of inflammatory and apoptotic pathways in human retinal endothelial cells (HRECs)...
  92. ncbi Postoperative hyperglycemia and surgical site infection in general surgery patients
    Ashar Ata
    Department of Surgery, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Arch Surg 145:858-64. 2010
    Postoperative hyperglycemia is an independent risk factor for postoperative surgical site infection (SSI).
  93. pmc LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice
    Rucha Patel
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 121:431-41. 2011
    ..g., dexamethasone) cause undesirable side effects that are features of the metabolic syndrome, including hyperglycemia, fatty liver, insulin resistance, and type II diabetes...
  94. ncbi Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury
    Satoru Kobayashi
    Cardiovascular Research Institute, Sanford Research, University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA
    J Biol Chem 282:21945-52. 2007
    b>Hyperglycemia is an independent risk factor for diabetic heart failure. However, the mechanisms that mediate hyperglycemia-induced cardiac damage remain poorly understood...
  95. pmc Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia
    Carin Gustavsson
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    PLoS ONE 5:e12699. 2010
    ..Here we investigated the impact of diabetes and dyslipidemia on VCAM-1 expression in mouse retinal vessels, as well as the potential role of tumor necrosis factor-α (TNFα)...
  96. ncbi Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America
    Lena Galvez Ranilla
    Escuela de Alimentos, Facultad de Recursos Naturales, Pontificia Universidad Catolica de Valparaiso, Avenida Waddington 716, Playa Ancha, Valparaiso, Chile
    Bioresour Technol 101:4676-89. 2010
    ..phenolic profiles, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension...
  97. pmc Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
    Luciano Pirola
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    Genome Res 21:1601-15. 2011
    ..We are only beginning to understand the dynamic role of some of the diverse epigenetic changes mediated by hyperglycemia at single loci, yet elevated glucose levels are thought to regulate genome-wide changes, and this still ..
  98. pmc Post-load hyperglycemia as an important predictor of long-term adverse cardiac events after acute myocardial infarction: a scientific study
    Shuichi Kitada
    Department of Cardiology, National Cardiovascular Center, Osaka, Japan
    Cardiovasc Diabetol 9:75. 2010
    ..In this study, we evaluated the relationship between glucometabolic status and MACE in patients after AMI, and determined the critical level of 2 h post-load plasma glucose that may be used to predict MACE...
  99. ncbi Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model
    Satoshi Hagiwara
    Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine, Oita, Japan
    Crit Care Med 36:2407-13. 2008
    b>Hyperglycemia and insulin resistance are commonly seen in septic patients and are associated with increased morbidity and mortality...
  100. pmc Hyperglycemia induces oxidative stress and impairs axonal transport rates in mice
    Ruchi Sharma
    Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e13463. 2010
    While hyperglycemia-induced oxidative stress damages peripheral neurons, technical limitations have, in part, prevented in vivo studies to determine the effect of hyperglycemia on the neurons in the central nervous system (CNS)...
  101. ncbi Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...

Research Grants76

  1. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..The primary goal of this proposal is to reduce hypertension and at the same time minimize hyperglycemia and glucose intolerance associated with insulin resistance...
  2. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    ..style, high fat (HF) diet during pregnancy has also been linked to vascular dysfunction, dyslipidemia and hyperglycemia in adults...
  3. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..RELEVANCE: Islet cell transplantation reverses hyperglycemia and normalizes metabolic control...
  4. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..as a mitochondrial-selective K+-ATP channel opener, providing profound cytoprotection without induction of hyperglycemia and diastolic hypotension...
  5. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..Diabetes and hyperglycemia are associated with enhanced production of reactive oxygen species and induce DNA damage by several mechanisms...
  6. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..address extensive organ damage in full-blown disease, a model that is seen in other vascular insults such as hyperglycemia, hypertension and hyperlipidemia...
  7. Notch and Regulators of Notch Signaling Impact Both Glucose and Lipid Metabolism
    UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2013
    ..is to demonstrate whether inhibition of Notch signaling is a viable therapeutic target in the correction of hyperglycemia and dyslipidemia characteristic of obesity-induced insulin resistance and the metabolic syndrome. Dr...
  8. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..factors (metabolic syndrome risk factor clustering: a combination of risk factors including central obesity, hyperglycemia, dyslipidemia, and hypertension)...
  9. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Type II diabetes and obesity are associated with dyslipidemia, hyperglycemia and insulin resistance...
  10. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ..might predict a subgroup of salt-sensitive hypertensives with lower risk for thiazide diuretic-induced hyperglycemia. We hypothesize that the STK39 genotypes of interest are not only associated with baseline BP, but also with ..
  11. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..Restoration of hepatic Elovl5 activity abrogated high fat diet-induced hyperglycemia, insulin resistance, and fatty liver in 4 days without changing body weight or appetite...
  12. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..In Aim 2, we will examine the role of peroxidasin and HOX in hyperglycemia induced renal cell dysfunction and matrix accumulation as an in vitro model of diabetic nephropathy...
  13. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..Acute administration of T1AM rapidly induces hypothermia, bradycardia, and hyperglycemia in rodents...
  14. JNK exacerbates ischemia/reperfusion injury in hyperglycemic subjects.
    Keith A Webster; Fiscal Year: 2010
    ..Inadequate glucose-stimulated insulin production and/or insulin resistance of muscle and liver cause hyperglycemia. We hypothesize that the exacerbated injury that accompanies myocardial ischemia/reperfusion in hyperglycemic ..
  15. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..g. pinacidil) and is free of the classic side-effects of sarcolemmal K+-ATP channel activation (hyperglycemia, ventricular fibrillation, hypotension)...
  16. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..Such low-grade inflammation in TLR5KO mice resulted in hyperglycemia, hyperlipidemia, hyperphagia, insulin resistance, obesity, hepatic steatosis and hypertension, collectively ..
  17. Modifiers of Cyst Progression in Polycystic Kidney Disease
    Phillip Darwin Bell; Fiscal Year: 2013
    ..Thus, hypertrophic signaling and hyperglycemia may be two extremely important regulators of disease progression in PKD...
  18. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..In animal models, hyperglycemia blocks the protection from I/R injury afforded by volatile anesthetics, and statins restore the protection and ..
  19. Comparative effectiveness of diabetes prevention strategies in women with GDM
    Assiamira Ferrara; Fiscal Year: 2010
    ..diabetes prevention strategies in women with gestational diabetes (GDM) for improving the following: obesity, hyperglycemia, hypertension and depression in a real-world clinical setting...
  20. Metabolic regulation of diabetic nephropathy
    Karen Block; Fiscal Year: 2013
    ..b>Hyperglycemia induces organ injury through complex pathways including the formation of advanced glycation end products (AGEs)..
  21. Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
    Robert V Farese; Fiscal Year: 2013
    ..of SREBP-1c/NF B, and fasting expression of PEPCK/G6Pase, thereby markedly improving obesity, hyperlipidemia, hyperglycemia, insulin signaling in muscle, and insulin resistance in obese/T2DM mice...
  22. Regulation of Islet Beta-Cell Function via Islet-Derived VGF Peptides
    SAMUEL BRANDON STEPHENS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Research Proposal Type 2 diabetes (T2D) is defined by hyperglycemia, caused by peripheral insulin resistance and insufficient release of insulin from the islet [unreadable]-cell...
  23. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..Single doses of T1AM rapidly induce hypothermia, bradycardia, and hyperglycemia in rodents...
  24. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..In the first 3+ years of this project we discovered that mice with chronic hyperglycemia are more susceptible to TB than controls with higher bacillary burden and worse lung pathology...
  25. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and is associated with abnormalities in carbohydrate, fat and protein metabolism resulting in chronic ..
  26. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hyperglycemia induces cardiovascular complications associated with increased morbidity and mortality...
  27. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..to avoid clinical complications that accompany prolonged shivering such as increased oxygen consumption and hyperglycemia. The agents currently used to prevent the shiver response produce respiratory depression and typically require ..
  28. Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DM
    DAVID BRADLEY contact LAUTZ; Fiscal Year: 2010
    ..demonstrate substantial and sustained weight loss, reductions in diabetes medications in 84%, and remission of hyperglycemia in 77% [2]...
  29. Hyperglycemia and Pregnancy Outcome(HAPO)Follow Up Study
    Boyd E Metzger; Fiscal Year: 2013
    ..The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-up Study will recruit from the cohort of women and their offspring ..
  30. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation
    Xianxin Hua; Fiscal Year: 2013
    ..Notably, Men1 excision not only renders mice resistant to streptozotocin (STZ)-induced hyperglycemia, but also ameliorates pre-existing hyperglycemia in STZ-induced diabetic mice...
  31. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..Inability of adequate [unreadable]-cell response to metabolic challenges results in hyperglycemia and frank diabetes mellitus...
  32. Insulin Signaling and Metabolic Effects through CLK2 Kinase
    Pere Puigserver; Fiscal Year: 2013
    ..Moreover, obese/diabetic db/db mice have lower amounts of Clk2 protein and restoration of the levels corrects hyperglycemia. This result suggests that Clk2 might be dysregulated in conditions of obesity/diabetes and contributes to the ..
  33. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2013
    ..Aim #3 will use in vitro and in vivo studies to confirm that hyperglycemia impairs [unreadable]-cell PPAR? signaling and consequently expression of its downstream regulated genes, and ..
  34. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..Conversely, the exogenous addition of BH4 to female gastric tissues in vitro reverses a hyperglycemia-induced decrease in nitrergic relaxation...
  35. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hyperglycemia induces cardiovascular complications associated with increased morbidity and mortality...
  36. Role of SIRT3 in fetal programming and kidney dysfunction
    Karen R Jonscher; Fiscal Year: 2013
    ..Jane Reusch, a clinical endocrinologist focused on understanding how diabetes, hyperglycemia and oxidative stress modulate activity of the cAMP Response Element Binding Protein in vascular disease;..
  37. Role of Oxidative Stress in Post-MI Cardiac Failure Associated with Diabetes
    MICHAEL FREDERICK HILL; Fiscal Year: 2013
    ..The injection of STZ in rats leads to the development of hyperglycemia, excessive urination, and loss of weight, all of which mimics human type I diabetes...
  38. Protein Modifications and Unfolded Protein Response in Diabetic Embryopathy
    Zhiyong Zhao; Fiscal Year: 2013
    ..However, how hyperglycemia activates DISC/caspase-8 remain to be delineated...
  39. Nonenzymatic glycation, bone quality, and microdamage in type 2 diabetic bone
    Eve Donnelly; Fiscal Year: 2013
    ..Formation of AGEs through nonenzymatic glycation of collagen associated with hyperglycemia has been proposed as a mechanism of impaired bone quality in diabetic bone, but the effect of AGEs on bone ..
  40. Role of inflammation and cellular stress in the pathogenesis of type 2 diabetes
    Liangyou Rui; Fiscal Year: 2013
    ..NIK null mice developed glucagon resistance and were protected from dietary hyperglycemia and hepatic steatosis. Deletion of NIK decreased lipogenesis and increased oxidation in hepatocytes...
  41. Maternal Obesity and Gestational Diabetes: Impact on Metabolome
    William L Lowe; Fiscal Year: 2013
    ..and a unique resource, stored serum samples from ~23,000 mothers and their offspring who were enrolled in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study...
  42. Glucocorticoids, Stress and Blood Pressure Regulation
    Deborah A Scheuer; Fiscal Year: 2013
    ..cause cardiovascular disease by generating risk factors including hypertension, abdominal obesity, hyperglycemia, insulin resistance, elevated triglycerides and cardiac arrhythmia...
  43. The role of SIRT1/FOXO4 pathway in podocyte apoptosis of diabetes mellitus
    PETER YENLUNG CHUANG; Fiscal Year: 2013
    ..Recent studies have shown that hyperglycemia and advanced glycation end products (AGEs) increase oxidant stress leading to podocyte apoptosis...
  44. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    DAVID ANTONETTI; Fiscal Year: 2013
    ..Vascular dysfunction in diabetic retinopathy may result from both the direct effect of hyperglycemia, advanced glycation end products, and hyperlipidemia on vascular endothelial cells and the indirect effect of ..
  45. Fatty Acid Defects &Oxidative Stress Modulate Islet Function in Cystic Fibrosis
    Aliye Uc; Fiscal Year: 2013
    ..Pancreatic disease advances rapidly in CF ferrets after birth and they develop progressive hyperglycemia, whereas the pancreatic disease progression is slower in CF pigs and they do not develop hyperglycemia as ..
  46. Characterization of the thioredoxins system in the diabetic retina
    Folami Lamoke; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Retinal capillary loss, due to hyperglycemia-induced vascular cell death, is a prominent feature of diabetic retinopathy (DR), a common complication of diabetes and the leading cause of blindness in ..
  47. Development of a novel method for inhibiting diabetic retinopathy
    David R Clemmons; Fiscal Year: 2012
    ..However directly inhibiting the IGF-I receptor may be lead to neurotoxicity. Following exposure to hyperglycemia, endothelial cells utilize both the PI-3 and MAP kinase pathways to activate changes in endothelial cell ..
  48. AMPK Endothelial Cell Dysfunction and the Metabolic Syndrome (PROGRAM PROJECT)
    Neil B Ruderman; Fiscal Year: 2013
    ..has been defined clinically as a disorder characterized by dyslipidemia, hypertension, central obesity, hyperglycemia and a predisposition to premature atherosclerotic cardiovascular disease and type 2 diabetes...
  49. Reperfusion and Neurovascular Injury in Stroke
    Pak H Chan; Fiscal Year: 2013
    ..We have also demonstrated that hyperglycemia, a known stroke risk factor, exacerbated reperfusion injury by enhancing MMP-9 activation, BBB damage, and ..
  50. Tunable Insulin Resistance in a Drosophila Model of Diabetes
    ELENA M GRACHEVA; Fiscal Year: 2010
    ..feeding flies a high sugar diet, phenocopies important physiology observed in human patients with T2DM, namely hyperglycemia, hyperinsulinemia, and triglyceride accumulation, and also recapitulates the endpoint outcome- shortened ..
  51. Cellular Mechanisms for Increased Gluconeogenesis in Type 2 Diabetes
    Varman T Samuel; Fiscal Year: 2013
    ..provided by applicant): In patients with T2D, increased hepatic gluconeogenesis is the main cause of fasting hyperglycemia. Many ascribed increased gluconeogenesis to increased transcription of phosphoenolpyruvate carboxykinase (..
  52. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George L King; Fiscal Year: 2013
    ..Abnormalities such as hyperlipidemia, insulin resistance and hyperglycemia are important risk factors for cardiovascular disease (CVD) in diabetes...
  53. CTGF promotes beta cell proliferation &revascularization in islet transplants
    Uma Gunasekaran; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Type 1 diabetes portends increased morbidity and mortality from hypoglycemia and hyperglycemia due to the imprecision of exogenous insulin administration...
  54. Hyperglycemia-induced DNA damage as a driver of genomic instability
    JOHN S TERMINI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obesity endgenders a wide spectrum of interrelated pathologies including hyperglycemia, insulin resistance, hyperlipidemia, and Type 2 diabetes, collectively termed the metabolic syndrome...
  55. Abnormal Bone Marrow Cells and Diabetic Neuropathy
    Lawrence Chan; Fiscal Year: 2013
    ..In diabetes, the hyperglycemia-induced PI-BMDCs circulate to the liver where they form fusion cells with hepatocytes (Fujimiya et al., 2007)...
  56. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation.
    Xianxin Hua; Fiscal Year: 2010
    ..Notably, Men1 excision not only renders mice resistant to streptozotocin (STZ)-induced hyperglycemia, but also ameliorates pre-existing hyperglycemia in STZ-induced diabetic mice...
  57. Role of H-Ras in Retinal Cell Death in Diabetes
    Renu A Kowluru; Fiscal Year: 2013
    ..will test the hypothesis that due to continued histone modifications, MMP-9 remains active after reversal of hyperglycemia, and the dysfunctional mitochondria continues to accelerate apoptosis of capillary cells...
  58. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ..mice, when fed a high fat diet, acquire symptoms similar to the Metabolic Syndrome;in which they develop hyperglycemia, hyperlipidemia, hyperinsulinemia and weight gain...
  59. MAP KINASE IN ISLET FUNCTION
    Melanie H Cobb; Fiscal Year: 2013
    ..to improve -cell function and overcome the physiological changes in cells that occur during prolonged hyperglycemia, contributing to inadequate insulin release...
  60. A Clinical Trial to Prevent New Onset Diabetes After Transplantation
    Akinlolu O Ojo; Fiscal Year: 2013
    ..metabolic engagement, 45-80% of new kidney transplant recipients (KTRs) will manifest persistent reversible hyperglycemia, 30% will maintain chronic impaired glucose intolerance and 15-20% will succumb to new onset diabetes after ..
  61. MOLECULAR REGULATION OF CORNEAL WOUND HEALING
    Fu Shin X Yu; Fiscal Year: 2013
    ..and preliminary studies lead to the hypothesis that the tightly regulated EGFR signaling is abrogated by hyperglycemia in the epithelium and that strengthening of the weakened EGFR signaling, along with reducing oxidative stress, ..
  62. GWA Mapping: Maternal Metabolism-Birth Weight Interactions
    WILLIAM LOWE; Fiscal Year: 2009
    ..a subset of ~37,000 DNA samples that were collected from mothers and their offspring as part of the NIH-funded Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study...
  63. A Mindfulness-Based Approach to the Treatment of Obesity and Diabetes
    Carla K Miller; Fiscal Year: 2010
    ..Obesity and diabetes encompass several body-mind relationships in bidirectional interactions such that hyperglycemia may adversely affect mood, and depressed mood may contribute to poor eating habits, physical inactivity, and ..
  64. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): We have shown that the first onset of hyperglycemia in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis ..
  65. Pediatric Type 1 diabetes: Intervention Trials With Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2010
    ..Paradoxical post-meal hyperglucagonemia is associated with post-prandial hyperglycemia in T1DM...
  66. Genistein for the Prevention and Treatment of Diabetic Vascular Inflammation
    Dongmin Liu; Fiscal Year: 2009
    ..b>Hyperglycemia-induced vascular inflammation, leading to monocyte adhesion to vascular endothelial cells (ECs), is the key ..
  67. Recurrence of T1D in Pancreas Transplantation
    George Burke; Fiscal Year: 2009
    ..While all patients became insulin-independent, 34 (15%) have returned to hyperglycemia after a mean follow-up of 5.7 years...
  68. Role of poly(ADP-ribosyl)ation in diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2004
    DESCRIPTION (provided by applicant):Hyperglycemia-induced oxidative stress affects multiple signal transduction and metabolic pathways...
  69. IGF-I PROTECTS NEURONS FROM GLUCOSE INDUCED CELL DEATH
    James Russell; Fiscal Year: 2001
    ..b>Hyperglycemia has been implicated in both animal and human studies in the pathogenesis of DN and recent clinical trials have ..
  70. IL-1 beta Signaling in Diabetic Retinopathy
    Susanne Mohr; Fiscal Year: 2010
    b>Hyperglycemia has been found experimentally to be sufficient to initiate the development of diabetic retinopathy, but the mechanism by which hyperglycemia causes the retinal disease remains unclear...
  71. MECHANISMS UNDERLYING CARDIOVASCULAR RISKS IN DIABETES
    Gordon Williams; Fiscal Year: 2000
    ..hypothesis to be tested in this investigation is that in diabetes mellitus (DM), it is hyperinsulinemia and hyperglycemia in combination with differences in the specific alleles of the genes of the renin-angiotensin and PAI-1 ..
  72. Increased Gluconeogenesis Is One Cause of CFRD
    DANA HARDIN; Fiscal Year: 2006
    ..Our global hypothesis is that increased rates of gluconeogenesis (GNG) result in hyperglycemia. This excess is not caused simply by portal hypoinsulinemia alone, but rather is driven by excessive amino ..
  73. Tissue-Specific Metabolic Reprogramming in Diabetic Complications
    Subramaniam Pennathur; Fiscal Year: 2011
    ..The prevailing view suggests that systemic hyperglycemia drives complications by similar biochemical mechanisms in all tissues...
  74. Regulation of Glucose Metabolism in Extremely Low Birth Weight (ELBW) Infants
    AGNETA LISBETH SUNEHAG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): . Hyperglycemia is frequently encountered when sick newborn infants receive TPN providing glucose exceeding the infant normal glucose turnover rate...
  75. HYPERGLYCEMIA-INDUCED NEURONAL SENSITIZATION
    Judith Richter; Fiscal Year: 2001
    ..The notion that hyperglycemia causes sensitization of the primary afferent neurons will be tested in the first aim...
  76. Proteome of Glomerular Cells in Diabetic Nephropathy
    Paul Voziyan; Fiscal Year: 2007
    The chronic hyperglycemia of diabetes leads to serious complications that include diabetic nephropathy, the leading cause of end-stage renal disease...