hypertriglyceridemia

Summary

Summary: Condition of elevated triglyceride concentration in the blood; an inherited form occurs in familial hyperlipoproteinemia IIb and HYPERLIPOPROTEINEMIA TYPE IV. It has been linked to higher risk of heart disease and arteriosclerosis.

Top Publications

  1. pmc Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Nat Genet 42:684-7. 2010
  2. ncbi Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    Sandeep Bansal
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 298:309-16. 2007
  3. pmc The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals
    Young Ah Moon
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Cell Metab 15:240-6. 2012
  4. pmc Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 93:243-52. 2011
  5. ncbi Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
    Babak Razani
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:8635-47. 2002
  6. pmc Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline
    Lars Berglund
    University of California, Davis, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 97:2969-89. 2012
  7. ncbi Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Pennsylvania State University, Department of Nutritional Sciences, University Park, PA, USA
    Expert Opin Pharmacother 9:1237-48. 2008
  8. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
  9. ncbi Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial)
    Harold E Bays
    Louisville Metabolic and Atherosclerosis Research Center, Kentucky, USA
    Am J Cardiol 108:682-90. 2011
  10. pmc Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada
    Circ Cardiovasc Genet 5:66-72. 2012

Detail Information

Publications365 found, 100 shown here

  1. pmc Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Nat Genet 42:684-7. 2010
    ..we show an accumulation of rare variants, or a mutation skew, in GWAS-identified genes in individuals with hypertriglyceridemia (HTG). Through GWAS, we identified common variants in APOA5, GCKR, LPL and APOB associated with HTG...
  2. ncbi Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    Sandeep Bansal
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 298:309-16. 2007
    ..Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role in atherosclerosis.
  3. pmc The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals
    Young Ah Moon
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Cell Metab 15:240-6. 2012
    Insulin resistance leads to hypertriglyceridemia and hepatic steatosis and is associated with increased SREBP-1c, a transcription factor that activates fatty acid synthesis...
  4. pmc Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 93:243-52. 2011
    ..Studies using higher doses have shown evidence of reduced inflammation and improved endothelial function. Few studies have compared these doses...
  5. ncbi Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
    Babak Razani
    Department of Molecular Pharmacology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:8635-47. 2002
    ..low density lipoproteins is not due to perturbed lipoprotein lipase activity, a major culprit of isolated hypertriglyceridemia. The lean body phenotype and metabolic defects observed in Cav-1 null mice are consistent with the ..
  6. pmc Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline
    Lars Berglund
    University of California, Davis, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 97:2969-89. 2012
    The aim was to develop clinical practice guidelines on hypertriglyceridemia.
  7. ncbi Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Pennsylvania State University, Department of Nutritional Sciences, University Park, PA, USA
    Expert Opin Pharmacother 9:1237-48. 2008
    Moderate hypertriglyceridemia is fairly common, and elevated triglycerides are a risk factor for coronary heart disease. The omega-3 fatty acids EPA and DHA have been shown to lower triglycerides in many clinical studies...
  8. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    ..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...
  9. ncbi Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial)
    Harold E Bays
    Louisville Metabolic and Atherosclerosis Research Center, Kentucky, USA
    Am J Cardiol 108:682-90. 2011
    ....
  10. pmc Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada
    Circ Cardiovasc Genet 5:66-72. 2012
    ..We sought to determine whether rare variants in non-GWAS candidate genes identified from mouse models and human mendelian syndromes of hypertriglyceridemia (HTG) accumulate in patients with polygenic adult-onset HTG.
  11. pmc Genetic determinants of plasma triglycerides
    Christopher T Johansen
    Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, Ontario N6A 5K8, Canada
    J Lipid Res 52:189-206. 2011
    ..Treatment of patients with moderate to severe hypertriglyceridemia with existing therapies is often challenging; thus, gene products and pathways found in recent genetic ..
  12. ncbi A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia
    Jau Tsuen Kao
    School and Graduate Institute of Medical Technology, College of Medicine, and Department of Laboratory Medicine, University Hospital, National Taiwan University, No 7, Chung Shan S Rd, Taipei, 100 Taiwan
    Hum Mol Genet 12:2533-9. 2003
    ..We describe here a novel variant, c.553G>T, in the apolipoprotein A5 gene that is associated with hypertriglyceridemia. In contrast to some other polymorphisms, which occur in non-coding regions of the gene, this variant ..
  13. ncbi Association of APOA5 -1131T>C and S19W gene polymorphisms with both mild hypertriglyceridemia and hyperchylomicronemia in type 2 diabetic patients
    Sybil Charriere
    INSERM U870, Universite de Lyon, Lyon, France
    Clin Chim Acta 394:99-103. 2008
    ..b>Hypertriglyceridemia is frequent in type 2 diabetes (T2D) and hyperchylomicronemia is not uncommon.
  14. ncbi Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment
    Antoniom Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
    Diabetes 53:701-10. 2004
    ..Elevated levels of these molecules have been reported in diabetic patients. Postprandial hypertriglyceridemia and hyperglycemia are considered risk factors for cardiovascular disease, and evidence suggests that ..
  15. ncbi Hypertriglyceridemia and cardiovascular risk reduction
    Terry A Jacobson
    Office of Health Promotion and Disease Prevention, Emory University, Atlanta, GA 30303, USA
    Clin Ther 29:763-77. 2007
    ..There is evidence that elevated TG levels may be a significant independent risk factor for coronary heart disease (CHD), particularly in women...
  16. pmc Obesity and hypertriglyceridemia produce cognitive impairment
    Susan A Farr
    Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Endocrinology 149:2628-36. 2008
    ..We found that hypertriglyceridemia, the main dyslipidemia of metabolic syndrome X, is in part responsible for the leptin resistance seen in ..
  17. pmc Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members
    Jennifer M MacArthur
    Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Clin Invest 117:153-64. 2007
    ..These findings show that under normal physiological conditions, hepatic heparan sulfate proteoglycans play a crucial role in the clearance of both intestinally derived and hepatic lipoprotein particles...
  18. ncbi Sugars, hypertriglyceridemia, and cardiovascular disease
    Susan K Fried
    Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA
    Am J Clin Nutr 78:873S-880S. 2003
    ..subjects with upper-body and visceral obesity who have the metabolic syndrome tend to be at higher risk for hypertriglyceridemia in response to high-sucrose and high-carbohydrate diets; moderate weight loss mitigates the effect...
  19. ncbi Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
    ..We propose that many of the factors that influence plasma triglyceride levels do so by converging upon the regulation of SCD activity...
  20. pmc Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes
    Susan Sam
    Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois, Chicago, Illinois
    Diabetes Care 32:1916-20. 2009
    ..Greater accumulation of visceral fat is strongly linked to risk of cardiovascular disease. However, elevated waist circumference by itself does not always identify individuals with increased visceral fat...
  21. pmc An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, Robarts Research Institute, University of Western Ontario, London, Canada
    Arterioscler Thromb Vasc Biol 31:1916-26. 2011
    ..the clinically heterogeneous polygenic Fredrickson hyperlipoproteinemia (HLP) phenotypes defined by hypertriglyceridemia (HTG)...
  22. ncbi Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding
    J J Repa
    Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:39685-92. 2000
    ..of fatty acids and accumulation of triacylglycerols increases in Cyp27(-/-) mice and is associated with hypertriglyceridemia. Cholic acid feeding reverses hepatomegaly and hypertriglyceridemia but not adrenomegaly in Cyp27(-/-) mice...
  23. ncbi Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement
    Genovefa D Kolovou
    Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 17674 Athens, Greece
    Curr Vasc Pharmacol 9:258-70. 2011
    ..7). A higher and undesirable postprandial TG response could be treated by aggressive lifestyle modification (including nutritional supplementation) and/or TG lowering drugs like statins, fibrates and nicotinic acid...
  24. ncbi Triglycerides and risk for coronary artery disease
    Patrick McBride
    Preventive Cardiology Program, University of Wisconsin School of Medicine and Public Health, 2150 HSLC, 750 Highland Avenue, Madison, WI 53705, USA
    Curr Atheroscler Rep 10:386-90. 2008
    ..Treatment of elevated TGs in clinical trials has been shown to reduce CVD events, cardiac deaths, and total mortality...
  25. ncbi Mitochondrial energy metabolism and redox responses to hypertriglyceridemia
    Luciane C Alberici
    Departamento de Fisica e Quimica, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    J Bioenerg Biomembr 43:19-23. 2011
    ..to evidence these adaptive mechanisms is especially useful for these studies since it exhibits genetic hypertriglyceridemia and avoids complications introduced by high fat diets...
  26. pmc CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1
    R Michael Gower
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Arterioscler Thromb Vasc Biol 31:160-6. 2011
    ..Involvement of β(2)-integrin CD11c/CD18 in atherogenesis was recently shown in dyslipidemic mice, which motivates our study of its inflammatory function during hypertriglyceridemia in humans.
  27. ncbi The -1131T-->C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men
    Yangsoo Jang
    Division of Cardiology, Cardiovascular Genome Center, Yonsei Medical Institute, Yonsei University, Seoul, Korea
    Am J Clin Nutr 80:832-40. 2004
    ..Apolipoprotein A5 plays an important role in modulating triacylglycerol metabolism in experimental animal models...
  28. ncbi Hypertriglyceridemia and residual dyslipidemia in statin-treated, patients with diabetes at the highest risk for cardiovascular disease and achieving very-low low-density lipoprotein-cholesterol levels
    Laurent Querton
    Service d endocrinologie et nutrition, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate UCL 54 74 B 1200 Brussels, Belgium
    J Clin Lipidol 6:434-42. 2012
    ..Because substantial residual risk persists at LDL-C <70 mg/dL, a more comprehensive control of non-LDL-C and particles was recommended in the joint 2008 American Diabetes Association/American College of Cardiology Consensus...
  29. ncbi A physician's guide for the management of hypertriglyceridemia: the etiology of hypertriglyceridemia determines treatment strategy
    B Klop
    Department of Internal Medicine, Diabetes and Vascular Center, Sint Franciscus Gasthuis Rotterdam, The Netherlands
    Panminerva Med 54:91-103. 2012
    b>Hypertriglyceridemia is a common lipid disorder associated to different, highly prevalent metabolic derangements like diabetes mellitus, the metabolic syndrome and obesity...
  30. ncbi Clinical and economic benefits observed when follow-up triglyceride levels are less than 500 mg/dL in patients with severe hypertriglyceridemia
    Jennifer B Christian
    Clinical Effectiveness and Safety, GlaxoSmithKline, 5 Moore Drive, B 3116, Durham, NC 27709 3398, USA
    J Clin Lipidol 6:450-61. 2012
    ..In this study we investigated the association between patients with severely increased triglycerides whose follow-up triglyceride levels were <500 mg/dL and reduction of important clinical events and associated health care costs...
  31. ncbi SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/A4/C3/A1 locus on chromosome 11q23 in the Northern Irish population
    William T Wright
    Centre for Clinical and Population Science, Queen s University, Belfast BT9 7AB, UK
    Atherosclerosis 185:353-60. 2006
    ..001), whereas in contrast, carriage of the APOC3 c102 T allele (odds ratio 1.35) and the APOC3 c.340 G allele (odds ratio 1.37), did not show any significant effects that were independent of APOA5...
  32. ncbi Cholelithiasis and markers of nonalcoholic fatty liver disease in patients with metabolic risk factors
    Tomas Koller
    5th Internal Medicine Department, Comenius University Medical School, University Hospital Bratislava, Bratislava, Slovakia
    Scand J Gastroenterol 47:197-203. 2012
    ..were women; 52% of patients had more than 2 metabolic risk factors (obesity, type 2 diabetes, hypertension, hypertriglyceridemia, or low HDL cholesterol)...
  33. ncbi Changes in body weight, glucose homeostasis, lipid profiles, and metabolic syndrome after restrictive bariatric surgery
    V T To
    Medical Department II Grosshadern, Ludwig Maximilians University Munich, Munich, Germany
    Exp Clin Endocrinol Diabetes 120:547-52. 2012
    ..Bariatric surgery is an established therapy for morbid obesity. We evaluated the effects of sleeve-gastrectomy on weight, glucose and lipid metabolism and prevalence of metabolic-syndrome for up to 2 years...
  34. ncbi Plasmapheresis as an adjuvant therapy for hypertriglyceridemia-induced pancreatitis
    Said B Iskandar
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Am J Med Sci 328:290-4. 2004
    b>Hypertriglyceridemia is an uncommon cause of pancreatitis. A serum triglyceride level of more then 1000 to 2000 mg/dL is an identifiable risk factor...
  35. ncbi Flow-mediated vasoactivity and circulating adhesion molecules in hypertriglyceridemia: association with small, dense LDL cholesterol particles
    G Lupattelli
    Section of Internal Medicine, Angiology and Atherosclerosis, University of Perugia, Perugia, Italy
    Am Heart J 140:521-6. 2000
    ..However, the independent association between hypertriglyceridemia and endothelial dysfunction is controversial, and the relation between endothelium-dependent vasodilation ..
  36. ncbi Severe hypertriglyceridemia influenced by alcohol (SHIBA)
    Kirsten Bessembinders
    Department of Internal Medicine, Meander Medical Centre, Amersfoort, The Netherlands
    Alcohol Alcohol 46:113-6. 2011
    This study was conducted to examine the relationship between triglyceride (TG) levels and a history of excessive drinking in patients with severe hypertriglyceridemia (HT).
  37. pmc The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results from the EPIC-Norfolk prospective population study
    Benoit J Arsenault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec
    CMAJ 182:1427-32. 2010
    Screening for increased waist circumference and hypertriglyceridemia (the hypertriglyceridemic-waist phenotype) has been proposed as an inexpensive approach to identify patients with excess intra-abdominal adiposity and associated ..
  38. pmc A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
    G Tuncman
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6970-5. 2006
    ..Taken together, our results indicate that reduction in aP2 activity in humans generate a metabolically favorable phenotype that is similar to aP2 deficiency in experimental models...
  39. ncbi Ethnic differences in the ability of triglyceride levels to identify insulin resistance
    Anne E Sumner
    Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States
    Atherosclerosis 196:696-703. 2008
    ..Each syndrome uses hypertriglyceridemia as a criterion. However, the definition of hypertriglyceridemia varies by syndrome i.e...
  40. ncbi Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812 8581, Japan
    J Nutr 135:155-9. 2005
    ..Because postprandial hypertriacylglycerolemia is a risk factor for coronary heart disease, our results suggest that catechins with a galloyl moiety may prevent this disease...
  41. ncbi Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles
    Alexandre C Ferreira
    University of Miami School of Medicine, Cardiovascular Center, Miami, Fla, USA
    Circulation 110:3599-603. 2004
    ....
  42. ncbi Mitochondrial ATP-sensitive K(+) channels as redox signals to liver mitochondria in response to hypertriglyceridemia
    Luciane C Alberici
    Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13083 887 Campinas, SP, Brazil
    Free Radic Biol Med 47:1432-9. 2009
    ..Therefore, a biological role for mitoK(ATP) as a redox sensor is shown here for the first time in an in vivo model of systemic and cellular lipid excess...
  43. ncbi Severe hypertriglyceridemia: an indication for apheresis?
    Nils Ewald
    Third Medical Department, University Hospital Giessen and Marburg, Giessen Site, Rodthohl 6, 35392 Giessen, Germany
    Atheroscler Suppl 10:49-52. 2009
    Severe hypertriglyceridemia is associated with a number of severe complications such as acute pancreatitis. Rapid lowering of excessively elevated triglyceride (TG) levels is therefore a primary medical goal in these patients...
  44. ncbi Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation: reversal with bezafibrate therapy in a randomized controlled trial
    Iris J Jonkers
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Med 112:275-80. 2002
    To determine whether hypertriglyceridemia is associated with systemic inflammation, which may contribute to the increased cardiovascular risk in patients who have hypertriglyceridemia...
  45. ncbi Effect of rosuvastatin 5-20mg on triglycerides and other lipid parameters in Japanese patients with hypertriglyceridemia
    Yasushi Saito
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Atherosclerosis 194:505-11. 2007
    ..The current study does not suggest a dose-related effect of rosuvastatin in lowering TG in hypertriglyceridemic Japanese patients, although dose-related improvements in other elements of the atherogenic lipid profile were observed...
  46. ncbi Investigation of hypertriglyceridemia in healthy Miniature Schnauzers
    Panagiotis G Xenoulis
    Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, 4474 TAMU, College Station, TX 77843, USA
    J Vet Intern Med 21:1224-30. 2007
    Idiopathic hypertriglyceridemia has been reported in Miniature Schnauzers (MS). However, studies investigating the prevalence of this disorder in a large population of MS are lacking.
  47. ncbi Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia
    Kwang Kon Koh
    Cardiology, Gachon University Gil Hospital, Incheon, Republic of Korea
    Atherosclerosis 220:537-44. 2012
    Omega-3 fatty acids and fenofibrate are both used to treat patients with hypertriglyceridemia. However, a head-to-head comparison of the lipoprotein and metabolic effects of these two medicines has not been published.
  48. ncbi Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia
    Cristina Revilla-Monsalve
    Metabolic Diseases Unit, Mexican Institute of Social Security, Mexico
    Biomed Pharmacother 60:182-5. 2006
    ..We conclude that pharmacological doses of biotin decrease hypertriglyceridemia. The triglyceride-lowering effect of biotin suggests that biotin could be used in the treatment of ..
  49. ncbi Hypertriglyceridemia increases mitochondrial resting respiration and susceptibility to permeability transition
    Luciane C Alberici
    Depto Patologia Clínica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13083 970 Campinas, Sao Paulo, Brazil
    J Bioenerg Biomembr 35:451-7. 2003
    ..b>Hypertriglyceridemia increased resting respiration and predisposed to mitochondrial permeability transition (MPT)...
  50. ncbi APOA5 Ala315>Val, identified in patients with severe hypertriglyceridemia, is a common mutation with no major effects on plasma lipid levels
    Jaroslav A Hubacek
    Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Clin Chem Lab Med 46:773-7. 2008
    ..The importance of the apolipoprotein A5 (APOA5) gene in determining plasma triglyceride (TG) levels has been demonstrated in transgenic and knockout mice and confirmed by human association studies in different ethnic groups...
  51. ncbi A novel experimental model of acute hypertriglyceridemia induced by schisandrin B
    Si Yuan Pan
    Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100102, China
    Eur J Pharmacol 537:200-4. 2006
    ..001). Hepatic triglyceride level was also decreased (by 100%, P<0.001) by co-treatment with fenofibrate. Our results suggest that schisandrin B treatment can be used to establish a mouse model of acute hypertrigylceridemia...
  52. ncbi The complex genetic basis of plasma triglycerides
    Christopher T Johansen
    Department of Medicine, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada
    Curr Atheroscler Rep 14:227-34. 2012
    ..Analyses in human patients with hypertriglyceridemia (HTG) also provides insight into the relationship between genetic variation, predisposition to elevated ..
  53. ncbi Periodontal disease and hypertriglyceridemia in Japanese subjects: potential association with enhanced lipolysis
    Hideo Nakarai
    Department of Dental Science for Health Promotion, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Metabolism 60:823-9. 2011
    ..These results suggest that periodontal infection, especially bacterial endotoxinemia, is associated with enhanced lipolysis and subsequent up-regulation of circulating TG in Japanese with midrange BMI...
  54. pmc Transient infantile hypertriglyceridemia, fatty liver, and hepatic fibrosis caused by mutated GPD1, encoding glycerol-3-phosphate dehydrogenase 1
    Lina Basel-Vanagaite
    Department of Pediatric Genetics, Schneider Children s Medical Center of Israel, Petah Tikva, Israel
    Am J Hum Genet 90:49-60. 2012
    The molecular basis for primary hereditary hypertriglyceridemia has been identified in fewer than 5% of cases. Investigation of monogenic dyslipidemias has the potential to expose key metabolic pathways...
  55. pmc Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects
    Léonie Egli
    Department of Physiology, University of Lausanne, Lausanne, Switzerland
    Diabetes 62:2259-65. 2013
    Excess fructose intake causes hypertriglyceridemia and hepatic insulin resistance in sedentary humans...
  56. pmc Triglycerides and heart disease: still a hypothesis?
    Ira J Goldberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 31:1716-25. 2011
    ..The time is more than ripe for new and creative approaches to understanding the relationship of triglycerides and heart disease...
  57. ncbi Treatment options for the management of hypertriglyceridemia: strategies based on the best-available evidence
    Kevin C Maki
    Biofortis Clinical Research, 211 E Lake Street, Addison, IL 60101, USA
    J Clin Lipidol 6:413-26. 2012
    ..trials exist to assess the efficacy of TG lowering for preventing pancreatitis in patients with severe hypertriglyceridemia. Similarly, no completed prospective outcomes trial exists to support or refute a reduction in CHD risk ..
  58. ncbi Overweight modulates APOE and APOA5 alleles on the risk of severe hypertriglyceridemia
    Ming Jen Lee
    Department of Neurology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Clin Chim Acta 416:31-5. 2013
    ..This study aimed to investigate whether the body mass index (BMI) in combination with genetic variations in APOE and APOA5_'T' alleles modulates the risk of sHTG...
  59. pmc ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice
    Guozhi Xiao
    Department of Biochemistry, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 288:25350-61. 2013
    b>Hypertriglyceridemia is the most common lipid disorder in obesity and type 2 diabetes. It results from increased production and/or decreased clearance of triglyceride-rich lipoproteins...
  60. ncbi Very-low-density lipoprotein response element in the promoter region of the human plasminogen activator inhibitor-1 gene implicated in the impaired fibrinolysis of hypertriglyceridemia
    P Eriksson
    King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 18:20-6. 1998
    b>Hypertriglyceridemia and impaired fibrinolytic function are linked to coronary heart disease and other atherothrombotic disorders...
  61. pmc Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy
    Sugato Banerjee
    Department of Neurosciences, USA bDepartment of Medicine, University of California, San Diego, California 92103 8231, USA
    AIDS 25:F1-6. 2011
    ..populations that are aging due to improved longevity with combination antiretroviral therapy (CART), both hypertriglyceridemia (hTRG) and sensory neuropathy have become increasingly common...
  62. pmc CD36 inhibitors reduce postprandial hypertriglyceridemia and protect against diabetic dyslipidemia and atherosclerosis
    Alain Geloen
    INSERM U1060, CarMeN laboratory, Lyon University, INSA Lyon, IMBL Villeurbanne, France
    PLoS ONE 7:e37633. 2012
    ..Thus, CD36 might represent an attractive therapeutic target...
  63. ncbi Clinical relevance of non-fasting and postprandial hypertriglyceridemia and remnant cholesterol
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Curr Vasc Pharmacol 9:281-6. 2011
    ..However, elevated remnant cholesterol may lead to cholesterol entrapment in the arterial intima and consequently to accelerated atherosclerosis and cardiovascular disease...
  64. ncbi Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies
    D C Chan
    Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Curr Atheroscler Rep 15:309. 2013
    Exaggerated postprandial hypertriglyceridemia is a risk factor for cardiovascular disease...
  65. ncbi Allelic and phenotypic spectrum of plasma triglycerides
    Christopher T Johansen
    Department of Medicine, University of Western Ontario, London, Ontario N6A 5K8, Canada
    Biochim Biophys Acta 1821:833-42. 2012
    ..Furthermore, GWAS in clinically ascertained hypertriglyceridemia (HTG) patients have shown that almost all of the same TG-raising alleles from epidemiologic samples are ..
  66. ncbi Hypertriglyceridemia secondary to obesity and diabetes
    Savitha Subramanian
    Diabetes Obesity Center of Excellence, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    Biochim Biophys Acta 1821:819-25. 2012
    b>Hypertriglyceridemia is a common lipid abnormality in persons with visceral obesity, metabolic syndrome and type 2 diabetes...
  67. pmc INSIG1 influences obesity-related hypertriglyceridemia in humans
    E M Smith
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 51:701-8. 2010
    ..00117). The variant rs2721 alone explains 5.4% of the observed linkage in our cohort, suggesting that additional, yet-undiscovered genes and sequence variants in the QTL interval also contribute to alterations in TG levels in humans...
  68. ncbi Hypertriglyceridaemia and low plasma HDL in a patient with apolipoprotein A-V deficiency due to a novel mutation in the APOA5 gene
    C Priore Oliva
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    J Intern Med 263:450-8. 2008
    ..Loss of function mutations of APOA5 gene may be the cause of severe HTG in patients without mutations in LPL and APOC2 genes...
  69. ncbi Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides
    Richard Sadovsky
    SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Postgrad Med 121:145-53. 2009
    ....
  70. ncbi All-cause and cardiovascular mortality in treated patients with severe hypertriglyceridaemia: A long-term prospective registry study
    H A W Neil
    NIHR School of Primary Care Research, Division Public Health and Primary Health Care, University of Oxford, Old Road, Headington, Oxford OX3 7LF, United Kingdom
    Atherosclerosis 211:618-23. 2010
    ..To examine all-cause and cardiovascular mortality in patients with severe hypertriglyceridaemia...
  71. ncbi Severe hypertriglyceridemia and pancreatitis: presentation and management
    Nils Ewald
    Third Medical Department, University Hospital Giessen and Marburg, Giessen Site, Rodthohl 6, Giessen, Germany
    Curr Opin Lipidol 20:497-504. 2009
    b>Hypertriglyceridemia (HTG) is a well recognized cause of acute pancreatitis accounting for approximately up to 10% of all cases and even up to 50% of all cases in pregnancy...
  72. pmc Mechanism of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase-deficient mice
    Ratnesh Kumar Singh
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G2W1, Canada
    J Lipid Res 53:1811-22. 2012
    ..deficiency leads to development of the metabolic syndrome phenotype, including liver steatosis, hypertriglyceridemia, obesity, and insulin resistance...
  73. ncbi Platelet nitric oxide production and IR: relation with obesity and hypertriglyceridemia
    Arianna Vignini
    Institute of Biochemistry, School of Medicine, Polytechnical University of Marche, Via P Ranieri 65, 60131 Ancona, Italy
    Nutr Metab Cardiovasc Dis 18:553-8. 2008
    ..The aim of the present work was to examine eNOS polymorphism, to find a correlation with platelet NO production and degree of insulin resistance (IR) in non-diabetic subjects and in patients affected by type 2 diabetes...
  74. ncbi Association of single-nucleotide polymorphism 3 and c.553G>T of APOA5 with hypertriglyceridemia after treatment with highly active antiretroviral therapy containing protease inhibitors in hiv-infected individuals in Taiwan
    Sui Yuan Chang
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan
    Clin Infect Dis 48:832-5. 2009
    We investigated the relationship between hypertriglyceridemia and the single-nucleotide polymorphisms (SNPs) on APOA5 in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) in Taiwan...
  75. ncbi Hypertriglyceridemia-induced acute pancreatitis--treatment with heparin and insulin
    Amitabh Monga
    Department of Internal Medicine, Sitaram Bhartia Institute of Science and Research, New Delhi 110 016
    Indian J Gastroenterol 22:102-3. 2003
    ..However, their efficacy in hypertriglyceridemia-induced acute pancreatitis is not well documented...
  76. ncbi The relative importance of common and rare genetic variants in the development of hypertriglyceridemia
    David Evans
    Endokrinologie und Stoffwechsel, Medizinische Klinik III, Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Expert Rev Cardiovasc Ther 9:637-44. 2011
    ..Resequencing studies are revealing the importance of rare variants in accounting for the missing variance. Next-generation sequencing will allow the relative importance of the two hypotheses to be assessed...
  77. ncbi Efficacy and safety of rosuvastatin and fenofibric acid combination therapy versus simvastatin monotherapy in patients with hypercholesterolemia and hypertriglyceridemia: a randomized, double-blind study
    Eli M Roth
    Sterling Research Group, Cincinnati, Ohio 45219, USA
    Am J Cardiovasc Drugs 10:175-86. 2010
    ....
  78. ncbi Acute pancreatitis due to hypertriglyceridemia: report of 2 cases
    Joong Ho Bae
    Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
    Korean J Gastroenterol 46:475-80. 2005
    b>Hypertriglyceridemia (HTG) is a rare but well known cause of acute pancreatitis (AP), which can be a life- threatening complication if the degree of HTG is severe enough...
  79. ncbi Mechanisms and consequences of hypertriglyceridemia and cellular lipid accumulation in chronic kidney disease and metabolic syndrome
    Hyun Soon Lee
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Histol Histopathol 26:1599-610. 2011
    b>Hypertriglyceridemia and intracellular lipid overload are commonly present in both the chronic kidney disease (CKD) and metabolic syndrome...
  80. ncbi Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia
    Philipp Kulozik
    Joint Division of Molecular Metabolic Control, DKFZ ZMBH Alliance, Center for Molecular Biology Heidelberg, University Hospital Heidelberg, Heidelberg, Germany
    Cell Metab 13:389-400. 2011
    ..Indeed, the liver-specific ablation of TBL1 gene expression in healthy mice promoted hypertriglyceridemia and hepatic steatosis under both normal and high-fat dietary conditions...
  81. ncbi Effect of omega-3 fatty acids on cardiovascular risk factors in patients with type 2 diabetes mellitus and hypertriglyceridemia: an open study
    D A de Luis
    Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, Valladolid, Spain
    Eur Rev Med Pharmacol Sci 13:51-5. 2009
    ..The aim of our study was to investigate the effectivity on triglyceride levels and inflammatory markers of a concentrated of n-3 fatty acids in patients with type 2 diabetes mellitus and hypertriglyceridaemia...
  82. ncbi Successful treatment of severe hypertriglyceridemia with a formula diet rich in omega-3 fatty acids and medium-chain triglycerides
    Annette Hauenschild
    Third Medical Department and Policlinic, University Hospital of Giessen and Marburg, Giessen, Germany
    Ann Nutr Metab 56:170-5. 2010
    ..In this study we describe the use of a new omega-3 fatty acid and medium-chain triglyceride-rich formula diet as a therapeutic concept to reduce plasma triglyceride levels fast and effectively...
  83. ncbi Acute hypertriglyceridemia is associated with peripheral vasodilation and increased basal flow in healthy young adults
    N Gokce
    Evans Department of Medicine, Cardiology Section and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 88:153-9. 2001
    ..To investigate the relation between acute hypertriglyceridemia and vascular function, we examined the effects of high- and low-fat meals on brachial artery reactivity in ..
  84. pmc Insulin resistance and its association with the components of the metabolic syndrome among obese children and adolescents
    Carlos Juárez-López
    Department for Innovation and Quality Institute for Decentralized Public Health Services, Indesalud, Campeche State, Mexico
    BMC Public Health 10:318. 2010
    ..The aim of this study is to assess the association between the degree of insulin resistance and the different components of the metabolic syndrome among obese children and adolescents...
  85. ncbi FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
    A Cederberg
    Medical Genetics, Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30, Goteborg, Sweden
    Cell 106:563-73. 2001
    ..induced by high fat diet, seem to counteract most of the symptoms associated with obesity, including hypertriglyceridemia and diet-induced insulin resistance--a likely consequence hereof would be protection against type 2 diabetes...
  86. pmc Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia
    Adelheid Kratzer
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21 3, 8010 Graz, Austria
    J Lipid Res 50:312-26. 2009
    ..protein-1c (SREBP1c) and carbohydrate response element-binding protein activation resulting in hypertriglyceridemia and liver steatosis...
  87. ncbi Paraoxonase 1 and platelet-activating factor acetylhydrolase activities in patients with low hdl-cholesterol levels with or without primary hypertriglyceridemia
    Fernando Daniel Brites
    Laboratorio de Lípidos y Lipoproteínas, Departamento de Bioquimica Clinica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Arch Med Res 35:235-40. 2004
    ..However, HDL reduction caused by primary hypertriglyceridemia has not been fully explored...
  88. ncbi Relation of the "hypertriglyceridemic waist" phenotype to earlier manifestations of coronary artery disease in patients with glucose intolerance and type 2 diabetes mellitus
    Julie St-Pierre
    Department of Medicine, Universite de Montreal, University of Montreal Community Genomic Medicine Center and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Quebec, Canada
    Am J Cardiol 99:369-73. 2007
    ....
  89. ncbi ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice
    E Voyiaziakis
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 39:313-21. 1998
    ..Male apoA-I-/- HuBTg mice exhibited hypertriglyceridemia when challenged with a high-fat diet...
  90. ncbi Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats
    Jian Mei Li
    From the State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
    Hepatology 51:1555-66. 2010
    ..We investigated the effects of curcumin on fructose-induced hypertriglyceridemia and liver steatosis and explored its preventive mechanisms in rats...
  91. ncbi One day of moderate energy deficit reduces fasting and postprandial triacylglycerolemia in women: the role of calorie restriction and exercise
    Maria Maraki
    Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
    Clin Nutr 29:459-63. 2010
    ..We sought to examine the effects of acute (1 day), moderate ( approximately 2 MJ) energy deficit induced by calorie restriction, exercise, or combination of both on fasting and postprandial triacylglycerol (TAG) metabolism in women...
  92. pmc Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 29:956-62. 2009
    ..Because GPIHBP1 deficiency causes chylomicronemia in mice, we sought to determine whether some cases of chylomicronemia in humans could be attributable to defective GPIHBP1 proteins...
  93. ncbi Diagnostic evaluation of acute pancreatitis in two patients with hypertriglyceridemia
    Yoshifumi Okura
    Division of Cardiology, Department of Internal Medicine, Fukuoka Dental College Hospital, 2 15 1, Tamura, Sawara ku, Fukuoka 814 0193, Japan
    World J Gastroenterol 10:3691-5. 2004
    We present two diagnostically challenging cases of acute pancreatitis with hypertriglyceridemia accompanied with chylomicronemia caused with a deficiency of lipoprotein lipase and with the presence of type V hyperlipidemia...
  94. ncbi Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects
    Marja Riitta Taskinen
    Department of Medicine, University of Helsinki, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 31:2144-50. 2011
    ..However, not all obese subjects develop the metabolic abnormalities associated with obesity. The aim of this study was to clarify the mechanisms that induce dyslipidemia in obese subjects...
  95. pmc Insulin and heparin in treatment of hypertriglyceridemia-induced pancreatitis
    Pankaj Jain
    World J Gastroenterol 13:2642-3. 2007
  96. ncbi Therapeutic plasma exchange in patients with severe hypertriglyceridemia: a multicenter study
    Claudia Stefanutti
    University of Rome La Sapienza, Umberto I Hospital, Department of Clinical and Medical Therapy, Plasmapheresis Unit, Rome, Italy
    Artif Organs 33:1096-102. 2009
    ..to evaluate the therapeutic efficacy of plasma-exchange plasmapheresis in treating patients with severe hypertriglyceridemia (sHTG), 17 patients who had not responded to conventional medical therapy (fat-free diet plus ..
  97. pmc Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
    H Abe
    Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 101:1784-8. 1998
    ..Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance...
  98. ncbi Inherited lipodystrophies and hypertriglyceridemia
    Vinaya Simha
    Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Curr Opin Lipidol 20:300-8. 2009
    ..Marked hypertriglyceridemia is a common feature of these disorders and highlights the role of adipose tissue in lipid homeostasis...
  99. ncbi Propofol-associated hypertriglyceridemia and pancreatitis in the intensive care unit: an analysis of frequency and risk factors
    John W Devlin
    School of Pharmacy, Northeastern University, and the Department of Pharmacy, Tufts New England Medical Center, Boston, Massachusetts 02115, USA
    Pharmacotherapy 25:1348-52. 2005
    To characterize the frequency, severity, risk factors, and clinician response to propofol-associated hypertriglyceridemia and hypertriglyceridemia-associated pancreatitis.
  100. pmc Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion
    Judy A Butler
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Arch Biochem Biophys 485:63-71. 2009
    ..LA-induced TG lowering was not due to the anorectic properties of LA, as pair-fed rats developed hypertriglyceridemia. Livers from LA-treated rats exhibited elevated glycogen content, suggesting dietary carbohydrates were ..
  101. ncbi Hypertriglyceridemia and its pharmacologic treatment among US adults
    Earl S Ford
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Arch Intern Med 169:572-8. 2009
    ..The prevalence of hypertriglyceridemia during a period of rising prevalence of obesity and its pharmacological treatment among US adults are ..

Research Grants64

  1. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..As increasing hepatic production of VLDL can lead to hypertriglyceridemia and increased LDL chol, betaine therapy will be tested in combination with reduced caloric intake...
  2. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..this disease includes elevated plasma low density lipoprotein (LDL)-cholesterol levels in association with hypertriglyceridemia, abdominal obesity, or insulin resistance...
  3. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2013
    ..decreased adipocyte FABP (arising via a polymorphism in the AFABP/aP2 promoter) exhibit reduced risk for hypertriglyceridemia, type 2 diabetes and cardiovascular disease...
  4. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    ..CREB-H deficient mice displayed severe hypertriglyceridemia secondary to inefficient TG clearance catalyzed by lipoprotein lipase (LPL)...
  5. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2011
    ..decreased adipocyte FABP (arising via a polymorphism in the AFABP/aP2 promoter) exhibit reduced risk for hypertriglyceridemia, type 2 diabetes and cardiovascular disease...
  6. Building Mouse Models of Metabolic Syndrome
    Karen L Svenson; Fiscal Year: 2013
    ..While the clustering of a subset of traits drawn from hypercholesterolemia, hypertriglyceridemia, reduced HDL-cholesterol, hypertension, obesity, and insulin resistance is a generally accepted guideline ..
  7. GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASE
    Rohit Loomba; Fiscal Year: 2013
    ..It is associated with metabolic syndrome traits including hypertension (HTN), insulin resistance (IR), and hypertriglyceridemia. These metabolic traits predict increased risk of NASH, which can lead to cirrhosis...
  8. Molecular Mechanisms of Mitigation of Insulin Induction of SREBP-1c by N-3 PUFA
    Marshall B Elam; Fiscal Year: 2013
    ..for the dyslipidemia that accompanies obesity, Type II Diabetes, and Metabolic Syndrome, primarily hypertriglyceridemia and low HDLC, are needed...
  9. Investigation of Nephrotic Syndrome
    LIONEL CLAUDIUS CLEMENT; Fiscal Year: 2013
    ..The immediate goal of the PI / applicant is to study in detail the mechanisms behind the development of hypertriglyceridemia in nephrotic syndrome...
  10. Human Cell-Based Models of Primary Adipocyte Disorders
    CHAD ALBERT COWAN; Fiscal Year: 2013
    ..They often develop diabetes mellitus, hypertriglyceridemia, and early- onset atherosclerosis...
  11. Activation of Atypical PKC by Insulin and Other Agonists
    ROBERT VITO FARESE; Fiscal Year: 2013
    ..abdominal obesity, hepatosteatosis, and hypertriglyceridemia and (b) restoration of insulin signaling in muscle, fat and liver, and normalization of serum glucose-..
  12. Structure-Based Design of Novel HNF4a Antagonists to Treat Metabolic Syndrome
    Arnold T Hagler; Fiscal Year: 2010
    ..They include insulin resistance, hypertension, dyslipidemia (i.e. hypertriglyceridemia and low HDL levels), glucose intolerance, and obesity...
  13. Development of PAR2 Inhibitors for the Treatment of Nonalcoholic steatohepatitis
    Athan Kuliopulos; Fiscal Year: 2013
    ..PZ-235 reduces fatty liver steatosis and hypertriglyceridemia by up to 50%, and suppresses lobular inflammation and systemic alanine aminotransferase (ALT) levels in ..
  14. The altered lipid and protein metabolism of pediatric patients with HIV infection
    Farook Jahoor; Fiscal Year: 2010
    ..include growth failure with lower lean body mass (LBM) and dyslipidemia, a syndrome characterized by hypertriglyceridemia and hypercholesterolemia...
  15. Long Term Implications of Preeclampsia: Role of Obesity vs sFlt-1 Overexpression
    Egle Bytautiene; Fiscal Year: 2009
    ..CVD, including endothelial dysfunction, thrombophilic predisposition, alterations in insulin sensitivity, hypertriglyceridemia, and proinflammatory changes...
  16. FATTY ACID BINDING PROTEINS-LIGAND SPECIFICITY
    Friedhelm Schroeder; Fiscal Year: 2010
    ..L-FABP null mice share many PPARa null mouse features (inhibition of LCFA oxidation, hypertriglyceridemia, sex/age-dependent obesity)...
  17. Epidemiologic Studies of Type 2 Diabetes in Normal Weight Adults
    MERCEDES RENEE CARNETHON; Fiscal Year: 2010
    ..g., type 2 diabetes [T2DM], hypertriglyceridemia, hypertension) in persons with normal body mass index (BMI)...
  18. Hepatocyte Clock and Alcoholic Fatty Liver Injury
    SHANNON MARIE BAILEY; Fiscal Year: 2011
    ..a high fat diet specifically at the end of the active period results in adiposity, hyperinsulinemia, and hypertriglyceridemia, which are independent of total daily caloric quantity...
  19. Adiponectin and Regulation of Triglyceride Metabolism
    Jianhua Shao; Fiscal Year: 2012
    b>Hypertriglyceridemia is a major component of the metabolic syndrome and a strong risk factor for atherosclerosis and coronary artery disease...
  20. Time-of-Day-Dependent Feeding Influences Myocardial Function
    MARTIN ELLIOT YOUNG; Fiscal Year: 2012
    ..a cardiometabolic syndrome phenotype (weight gain, adiposity, glucose intolerance, hyperinsulinemia, hypertriglyceridemia, and hyperleptinemia, compared to mice fed the same meal at the beginning of the active/awake period)...
  21. Atypical Antipsychotics: Effects on Hepatic Glucose and Lipid Metabolism in Human
    Michael R Rickels; Fiscal Year: 2012
    ..We have found increased endogenous glucose production, post-prandial hyperinsulinemia and hypertriglyceridemia as well as decreased insulin sensitivity after only 9 days of olanzapine administration to healthy control ..
  22. Global HIV Drug Therapies and Mitochondrial Complications and Mechanisms
    Mariana Gerschenson; Fiscal Year: 2012
    ..As hypertriglyceridemia and insulin resistance are also frequently observed in association with lipoatrophy;the use of d4T or ZDV ..
  23. FFA Production From Triglyceride-Rich Lipoproteins
    John M Miles; Fiscal Year: 2013
    ..the splanchnic bed found very high rates of splanchnic spillover in overweight and obese individuals with hypertriglyceridemia. Subsequent studies have shown that intravenous infusion of niacin, a drug known to suppress FFA release, ..
  24. Apolipoprotein A-V: A Functional Proteomics Study
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Statement of Relevance Hypertriglyceridemia is an independent risk factor for cardiovascular disease and is a recognized contributor to development of ..
  25. Vitamin D Status in Relation to Incident Type 2 Diabetes and Cardiometabolic Risk
    Anastassios G Pittas; Fiscal Year: 2010
    ..ATP-III definition) and its individual components (central adiposity, hypertension, low HDL-cholesterol, hypertriglyceridemia and glycemia). (3)...
  26. Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia
    Jean Marc Schwarz; Fiscal Year: 2013
    ..There is considerable evidence to support the hypothesis that postprandial hypertriglyceridemia is a key metabolic disturbance that gives rise to the lipid dysregulation characteristic of metabolic ..
  27. Hepatic Rictor Knockout Mouse Model and the Metabolic Syndrome
    JENNIFER MARIE ROJAS; Fiscal Year: 2012
    ..AKT (only T308) is sufficient to phosphorylate and inhibit GSK3, leading to SREBP1c activation and hypertriglyceridemia. I will test this hypothesis by studying a mouse model in which the mTORC2 regulatory protein, rictor, has ..
  28. Effects of amino acids on regional lipid metabolism
    Elisabet Borsheim; Fiscal Year: 2013
    The overall goal of this project is to understand mechanisms underlying hypertriglyceridemia (elevated triglyceride [TG] concentration in blood) and to find novel treatments against this condition...
  29. Effects of recombinant human leptin in nonalcoholic fatty liver disease (NAFLD)
    Elif Arioglu Oral; Fiscal Year: 2013
    ..We showed that leptin therapy in the setting of non-HIV lipodystrophy reverses insulin resistance, hypertriglyceridemia and nonalcoholic fatty liver disease (NAFLD)...
  30. Energy Expenditure in HIV Lipodystrophy
    Lisa A Kosmiski; Fiscal Year: 2012
    ..is characterized by extensive subcutaneous fat loss and is associated with insulin resistance, diabetes and hypertriglyceridemia. We have found that HIV LD is also associated with increased resting (REE) and total daily energy ..
  31. Antibodies to Define Molecular Mechanisms of Hypertriglyceridemia
    Stephen G Young; Fiscal Year: 2010
    ..We will use antibody probes to better define the pathogenesis of hypertriglyceridemia. Hypertriglyceridemia is caused by inherited defects in lipoprotein lipase (LPL), but the etiology of most ..
  32. The role of hepatic insulin resistance on SR-BI dependant HDL cholesterol uptake
    DENEYS REM VAN DER WESTHUYZEN; Fiscal Year: 2013
    ..THCE) elimination of HDL cholesterol in bile is reduced in the setting of hepatic insulin resistance and hypertriglyceridemia. This will be accomplished by a) determining whether reduced SR-BI function diminishes THCE of HDL-C, b) ..
  33. Genetic Determinants of Weight Loss and Resolution of Co-Morbidities
    Glenn S Gerhard; Fiscal Year: 2013
    ..metabolic derangements including type 2 diabetes mellitus (T2D), hypertension (HTN), dyslipidemia including hypertriglyceridemia (hiTRI) and low HDL levels (loHDL), as well as cardiovascular disease and overall mortality...
  34. Transport of Lipoprotein Lipase by Heparan Sulfate Proteoglycans
    Jon C Gonzales; Fiscal Year: 2011
    ..Impairments in the expression, transport, or function of lipoprotein lipase can lead to hypertriglyceridemia, atherosclerosis, and other cardiovascular diseases...
  35. Genetics of high serum triglycerides and related metabolic traits in Mexicans
    Paivi Pajukanta; Fiscal Year: 2013
    ..Gene expression data from fat biopsies from 50 Mexican subjects with hypertriglyceridemia and 50 with normolipidemia will be utilized as an additional filter to select DNA variants for stage 2 of ..
  36. Insulin Regulation of Liver X Receptor in Normal and Insulin Resistant States
    Ji Miao; Fiscal Year: 2013
    ..insulin resistance, which affects more than one third of adults in the US, causes increased lipogenesis, hypertriglyceridemia and a greater than 2-fold increase in the risk of CVD...
  37. New Insights into Lipoprotein Lipase and Lipolysis
    Stephen G Young; Fiscal Year: 2013
    ..We showed that an absence of GPIHBP1 in mice causes severe hypertriglyceridemia (chylomicronemia) and that humans with GPIHBP1 mutations exhibit the same phenotype...
  38. Genetic Analysis of Proteoglycan-Mediated Lipoprotein Clearance
    Jeffrey D Esko; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Genetic Analysis of Proteoglycan-Mediated Lipoprotein Clearance. Hypertriglyceridemia results from the accumulation of triglyceride-rich lipoproteins (TRLs) in the circulation (chylomicrons, very low-..
  39. Epigenetic Determinants of Lipid Response to Dietary Fat and Fenofibrate
    Donna K Arnett; Fiscal Year: 2013
    ..has fueled interest to better understand environmental factors responsible for dyslipidemias, especially hypertriglyceridemia. Epigenetic variations may affect triglyceride (TG) metabolism and response to environmental challenges...
  40. Foxo1 in Triglyceride Metabolism
    Hengjiang Henry Dong; Fiscal Year: 2010
    b>Hypertriglyceridemia is the commonest lipid disorder associated with insulin resistance and type 2 diabetes...
  41. Risk and protective factors for SGA-induced metabolic syndrome in bipolar youth
    Robert K McNamara; Fiscal Year: 2013
    ..Recent evidence also suggests that stearoyl-CoA desaturase, a lipogenic enzyme implicated in hypertriglyceridemia, insulin resistance, and obesity, may mediate the detrimental effects of SGA medications as well as the ..
  42. Functions of apoE in cholesterol and triglyceride homeostasis
    Vassilis I Zannis; Fiscal Year: 2010
    ..physiological range clears lipoprotein remnants, high levels of expression of apoE2, apoES, or apoE4 causes hypertriglyceridemia. We have established recently that the hypertriglyceridemia is mediated to a large extent by hydrophobic ..
  43. Phase 2 Study of Orlistat and SLX-4090 for Type I Hyperlipoproteinemia
    Abhimanyu Garg; Fiscal Year: 2012
    ..Type I hyperlipoproteinemia is a rare, autosomal recessive metabolic disorder characterized by extreme hypertriglyceridemia due to a deficiency in lipoprotein lipase or related proteins...
  44. Pretreatment genotyping at APOA5 and GCKR loci and response to fenofibrate therap
    Edmond Kato Kabagambe; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Fenofibrate is one of the best options for treating hypertriglyceridemia. In the majority of patients, fenofibrate lowers triglycerides by 24-55% and improves HDL- and LDL-cholesterol...
  45. Induction of coronary ateriogenesis by reprogrammed cells
    Liya Yin; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Patients with metabolic syndrome (a condition characterized by abnormal obesity, hypertriglyceridemia, insulin resistance and hyperinsulinemia) have a high risk of ischemic heart disease and nearly 30~40% of ..
  46. Skeletal Muscle Microcirculation in Obese Zucker Rats
    Jefferson Frisbee; Fiscal Year: 2009
    ..X on the peripheral microcirculation, as owing to chronic hyperphagia, OZR sequentially develop type II DM, hypertriglyceridemia, and moderate hypertension...
  47. Regulation of hepatic lipid metabolism by a novel Foxo pathway
    XIAOCHENG CHARLIE DONG; Fiscal Year: 2013
    ..members (Foxos) and their potential downstream effector(s) in the development of hepatic steatosis and hypertriglyceridemia. Foxos have been implicated in the regulation of hepatic lipogenesis and very-low-density lipoprotein (VLDL)..
  48. Triglycerides and Triglyceride-Rich Particles in Health and Disease
    Andrew D Robertson; Fiscal Year: 2010
    ..The clinical relevance of hypertriglyceridemia, new insights into the mechanisms of pharmacological treatment of hypertriglyceridemia, and clinical trial ..
  49. DIETARY LIPIDS--EFFECTS ON LIPID-LIPOPROTEIN METABOLISM
    D Illingworth; Fiscal Year: 1991
    ..acid by determining if these purified fatty acids (as dietary constituents) prevent carbohydrate induced hypertriglyceridemia. The mechanisms responsible for the reduction of HDL concentrations in hypercholesterolemic subjects fed a ..
  50. Vascular mimetics to study inflammation and atherosclerosis
    SCOTT IRWIN SIMON; Fiscal Year: 2013
    ..3) Identify the earliest events linked to hypertriglyceridemia and obesity that increase monocyte proclivity to arrest on atherogenic endothelium using a lab-on-a-chip ..
  51. Estrogenic activity of uranium in vitro and in vivo
    CHERYL DYER; Fiscal Year: 2007
    ..the global effects of lifetime hyperandrogenism by analyzing onset of insulin resistance, hyperglycemia, hypertriglyceridemia and deposition of truncal fat...
  52. Identifying functional variation in schizophrenia GWAS loci by pooled sequencing
    ERIK LOKEN; Fiscal Year: 2013
    ..g., for hypertriglyceridemia and Crohn's disease)...
  53. PROTEASE INHIBITOR-INDUCED HYPERLIPIDEMIA IN AIDS
    Virgil Brown; Fiscal Year: 2004
    ..The production of apoC-III, a PPAR- regulated apolipoprotein linked to hypertriglyceridemia and diabetes, will be examined with respect to its association in PI-induced hypertriglyceridemia...
  54. NUTRITIONAL EFFECTS OF SUGARS ON LIVER LIPIDS
    CHARLES SPARKS; Fiscal Year: 1990
    ..In the sucrose model significant hypercholesterolemia and hypertriglyceridemia occur followed by early atherosclerotic changes in ten to twenty weeks...
  55. FISH OILS AND LIPOPROTEIN METABOLISM
    William Harris; Fiscal Year: 1992
    ..than 20 gm/day) have found significant elevations in LDL cholesterol levels, especially in patients with hypertriglyceridemia (HTG). Thus, the usefulness of fish oil may be limited in this population...
  56. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
    ..e., acetylcholine) seen in hypercholesterolemic patients are also observed in patients with isolated hypertriglyceridemia or mixed hyperlipidemia (familial combined hyperlipidemia)...
  57. Antiadipogenic Influence of HIV Protease Inhibitors
    M Lane; Fiscal Year: 2005
    ..Patients with LDS often show signs of insulin resistance and hypertriglyceridemia. Our central hypothesis is that the lipoatrophy is related to a selective atrophic effect of PIs on the ..
  58. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
    ..tardive dyskinesia with "typical antipsychotics" and significant weight gain and associated hyperlipidemia, hypertriglyceridemia, diabetes mellitus, hepatic abnormalities, and at times mortality with the "atypical" antipsychotics...
  59. PPAR Mediated Gene Expression in HIV Patients
    Marie Gelato; Fiscal Year: 2007
    ..hypothesis of this proposal is that loss of peripheral adipose tissue, diminished insulin sensitivity, and hypertriglyceridemia are the result of a reduction in the native ligands for the peroxisome proliferator-activated receptor (..
  60. Molecular Signaling of Rapamycin Induced Hyperlipidemia
    GHADA SOLIMAN; Fiscal Year: 2004
    b>Hypertriglyceridemia is a major risk factor for cardiovascular disease (CVD), and is associated with insulin resistance. Rapamycin (RAPA) is a potent antiproliferative and immunosuppressive drug that reduces acute graft rejection...
  61. SMALL, DENSE LDL IN THE PATHOGENESIS OF PREECLAMPSIA
    Carl Hubel; Fiscal Year: 1999
    ..Clinically evident preeclampsia is preceded by marked hypertriglyceridemia. Metabolic changes producing elevated triglycerides can also shift the low-density lipoprotein (LDL) ..
  62. IN VIVO DYNAMIC OF BETA-CAROTENE METABOLISM IN HUMANS
    Andrew Clifford; Fiscal Year: 2006
    ..VLDL) origins is emerging as a leading risk factor for atherosclerosis, however, it is unclear whether hypertriglyceridemia is a defect in secretion, hydrolysis, and/or particle uptake...
  63. VLDL, ATHEROSCLEROSIS, AND THROMBOSIS-MECHANISTIC LINKS
    William Bradley; Fiscal Year: 1993
    Atherosclerotic and thrombotic disorders like CAD, MI, and hypercoagulability are associated with hypertriglyceridemia (HTG) by unknown mechanisms...
  64. Phamracogenetics of Hypertriglyceridemia in Hispanics
    Stanley Korenman; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hypertriglyceridemia is being increasingly recognized as an independent risk factor for cardiovascular disease...