hypercholesterolemia

Summary

Summary: Abnormally high levels of cholesterol in the blood.

Top Publications

  1. ncbi Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    Scott M Grundy
    Circulation 110:227-39. 2004
  2. pmc Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
    Filip K Swirski
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Clin Invest 117:195-205. 2007
  3. ncbi Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    C Baigent
    Lancet 366:1267-78. 2005
  4. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
  5. ncbi Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    S H Zhang
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Science 258:468-71. 1992
  6. ncbi Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
    James M McKenney
    Virginia Commonwealth University and National Clinical Research, Inc, Richmond, USA
    J Am Coll Cardiol 59:2344-53. 2012
  7. ncbi Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
    Scott M Grundy
    J Am Coll Cardiol 44:720-32. 2004
  8. ncbi ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    Y Nakashima
    Department of Pathology, University of Washington, Seattle 98195
    Arterioscler Thromb 14:133-40. 1994
  9. pmc Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis
    Roland Klingenberg
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 123:1323-34. 2013
  10. pmc Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Clin Invest 92:883-93. 1993

Research Grants

  1. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
  2. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
  3. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
  4. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2013
  5. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda M Graham; Fiscal Year: 2013
  6. MOUSE MODEL FOR DISEASES OF PROTEIN MISFOLDING
    P Michael Conn; Fiscal Year: 2012
  7. Building Mouse Models of Metabolic Syndrome
    Karen L Svenson; Fiscal Year: 2013
  8. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
  9. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
  10. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012

Detail Information

Publications383 found, 100 shown here

  1. ncbi Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    Scott M Grundy
    Circulation 110:227-39. 2004
    ..Finally, for people in lower-risk categories, recent clinical trials do not modify the goals and cutpoints of therapy...
  2. pmc Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
    Filip K Swirski
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Clin Invest 117:195-205. 2007
    ..b>Hypercholesterolemia-associated monocytosis (HAM) developed from increased survival, continued cell proliferation, and impaired ..
  3. ncbi Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    C Baigent
    Lancet 366:1267-78. 2005
    ..But each separate trial has limited power to assess particular outcomes or particular categories of participant...
  4. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    ..This marked hypercholesterolemia is primarily due to elevated levels of very low and intermediate density lipoproteins...
  5. ncbi Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    S H Zhang
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Science 258:468-71. 1992
    ..The severe yet viable phenotype of the mutants should make them valuable for investigating genetic and environmental factors that modify the atherogenic process...
  6. ncbi Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
    James M McKenney
    Virginia Commonwealth University and National Clinical Research, Inc, Richmond, USA
    J Am Coll Cardiol 59:2344-53. 2012
    ..Secondary objectives included evaluation of effects on other lipid parameters and the attainment of LDL-C treatment goals of <100 mg/dl (2.59 mmol/l) and <70 mg/dl (1.81 mmol/l)...
  7. ncbi Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
    Scott M Grundy
    J Am Coll Cardiol 44:720-32. 2004
    ..Finally, for people in lower-risk categories, recent clinical trials do not modify the goals and cutpoints of therapy...
  8. ncbi ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
    Y Nakashima
    Department of Pathology, University of Washington, Seattle 98195
    Arterioscler Thromb 14:133-40. 1994
    ..description of apolipoprotein (apo) E-deficient transgenic mice demonstrated the development of severe hypercholesterolemia due to probable delayed clearance of large atherogenic particles from the circulation...
  9. pmc Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis
    Roland Klingenberg
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Clin Invest 123:1323-34. 2013
    ..These results demonstrate that FOXP3(+) Tregs inhibit atherosclerosis by modulating lipoprotein metabolism...
  10. pmc Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Clin Invest 92:883-93. 1993
    ....
  11. ncbi Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
    Eli M Roth
    Sterling Research Group, Cincinnati, OH, USA
    N Engl J Med 367:1891-900. 2012
    ..REGN727/SAR236553 (designated here as SAR236553), a fully human PCSK9 monoclonal antibody, increases the recycling of LDL receptors and reduces LDL cholesterol levels...
  12. pmc Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
    M Kivipelto
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    BMJ 322:1447-51. 2001
    ..To examine the relation of midlife raised blood pressure and serum cholesterol concentrations to Alzheimer's disease in later life...
  13. ncbi Midlife cardiovascular risk factors and risk of dementia in late life
    R A Whitmer
    Kaiser Permanente Division of Research, 2000 Broadway, Oakland, CA 94612, USA
    Neurology 64:277-81. 2005
    ..To evaluate if midlife cardiovascular risk factors are associated with risk of late-life dementia in a large, diverse cohort...
  14. pmc Trends in self-reported prevalence and management of hypertension, hypercholesterolemia and diabetes in Swiss adults, 1997-2007
    Daniel Estoppey
    Institute of Social and Preventive Medicine, University Hospital, Faculty of Biology and Medicine, Bugnon, Lausanne, Switzerland
    BMC Public Health 11:114. 2011
    ..little is known regarding prevalence and management of cardiovascular risk factors (CV RFs: hypertension, hypercholesterolemia and diabetes) in the general population...
  15. pmc Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?
    Christian Humpel
    Laboratory of Psychiatry and Exp Alzheimers Research, Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Austria
    Exp Gerontol 46:225-32. 2011
    ..It is suggested that (vascular) risk factors (e.g. hypercholesterolemia, type 2 diabetes, hyperhomocysteinemia) causes either damage of the cerebrovascular system including silent ..
  16. ncbi Effectiveness and costs of interventions to lower systolic blood pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease risk
    Christopher J L Murray
    Evidence and Information for Policy, World Health Organization, 27, Geneva, Switzerland
    Lancet 361:717-25. 2003
    ....
  17. ncbi Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
    David Cunningham
    Pfizer Inc, Eastern Point Road, Groton, Connecticut 06430, USA
    Nat Struct Mol Biol 14:413-9. 2007
    ..The D374Y gain-of-function mutant, associated with hypercholesterolemia and early-onset cardiovascular disease, binds the receptor 25 times more tightly than wild-type PCSK9 at ..
  18. pmc Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients
    Kwang Kon Koh
    Department of Cardiology, Gachon University, Gil Medical Center, Incheon, Korea
    J Am Coll Cardiol 55:1209-16. 2010
    ..We investigated whether atorvastatin might decrease insulin sensitivity and increase ambient glycemia in hypercholesterolemic patients...
  19. ncbi Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis
    Harry R Davis
    Department of Cardiovascular Metabolic Disease and Department of Discovery Technologies, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 279:33586-92. 2004
    ..The NPC1L1 null mice were completely resistant to diet-induced hypercholesterolemia, with plasma lipoprotein and hepatic cholesterol profiles similar to those of wild type mice treated with ..
  20. pmc Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish
    Konstantin Stoletov
    Department of Pathology, University of California at San Diego, La Jolla 92093 0682, USA
    Circ Res 104:952-60. 2009
    ..Here we report that feeding adult zebrafish (Danio rerio) a high-cholesterol diet (HCD) resulted in hypercholesterolemia, remarkable lipoprotein oxidation, and fatty streak formation in the arteries...
  21. ncbi Long-term follow-up of the West of Scotland Coronary Prevention Study
    Ian Ford
    Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom
    N Engl J Med 357:1477-86. 2007
    ..Coronary Prevention Study was a randomized clinical trial comparing pravastatin with placebo in men with hypercholesterolemia who did not have a history of myocardial infarction, with an average follow-up of approximately 5 years...
  22. ncbi A systematic review and meta-analysis on the therapeutic equivalence of statins
    T C Weng
    Institute of Clinical Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Clin Pharm Ther 35:139-51. 2010
    Statins are the most commonly prescribed agents for hypercholesterolemia because of their efficacy and tolerability...
  23. pmc Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia
    Jonathan Rios
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Hum Mol Genet 19:4313-8. 2010
    ..Her parents had normal plasma cholesterol levels and reported no family history of hypercholesterolemia, suggesting either an autosomal recessive disorder or a de novo mutation...
  24. ncbi NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
    Suzanne Benjannet
    Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 279:48865-75. 2004
    ..In conclusion, NARC-1 seems to affect both the level of LDLR and that of circulating apoB-containing lipoproteins in an LDLR-dependent and -independent fashion...
  25. ncbi MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart
    Zoltán V Varga
    Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Szeged, Hungary
    J Mol Cell Cardiol 62:111-21. 2013
    Diet-induced hypercholesterolemia leads to oxidative/nitrative stress and subsequent myocardial dysfunction. However, the regulatory role of microRNAs in this phenomenon is unknown...
  26. ncbi Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial
    Haruo Nakamura
    Mitsukoshi Health and Welfare Foundation, Tokyo, Japan
    Lancet 368:1155-63. 2006
    ..Our aim was to assess whether evidence for treatment with statins derived from western populations can be extrapolated to the Japanese population...
  27. ncbi Explaining the increase in coronary heart disease mortality in Beijing between 1984 and 1999
    Julia Critchley
    International Health Research Group, Liverpool School of Tropical Medicine, UK
    Circulation 110:1236-44. 2004
    ..We examined how much of the increase in CHD mortality in Beijing, China, between 1984 and 1999 could be attributed to changes in major cardiovascular risk factors and assessed the impact of medical and surgical treatments...
  28. ncbi Hypercholesterolemia impairs angiogenesis in patients with breast carcinoma and, therefore, lowers the risk of metastases
    Binnaz Handan Ozdemir
    Department of Pathology, Baskent University Faculty of Medicine, Ankara, Turkey
    Am J Clin Pathol 122:696-703. 2004
    Our aim was to study the effect of hypercholesterolemia on angiogenesis induced by breast carcinoma. Of 51 patients with invasive ductal carcinoma, 28 had hypercholesterolemia and 23 had normocholesterolemia...
  29. ncbi Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity
    J Stamler
    Northwestern University Medical School, Department of Preventive Medicine, 680 N Lake Shore Dr, Suite 1102, Chicago, IL 60611 4402 USA
    JAMA 284:311-8. 2000
    ..However, findings for younger people are limited, and the value of detecting and treating hypercholesterolemia in younger adults is debated.
  30. ncbi Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels
    Martijn B Katan
    Division of Human Nutrition and Epidemiology, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Mayo Clin Proc 78:965-78. 2003
    ..However, present evidence is sufficient to promote use of sterols and stanols for lowering LDL cholesterol levels in persons at increased risk for coronary heart disease...
  31. ncbi Water extracts of cinnamon and clove exhibits potent inhibition of protein glycation and anti-atherosclerotic activity in vitro and in vivo hypolipidemic activity in zebrafish
    Seori Jin
    School of Biotechnology, Yeungnam University, Gyeongsan 712 749, Republic of Korea
    Food Chem Toxicol 49:1521-9. 2011
    ..These results suggest the potential to develop a new functional dietary agent to treat chronic metabolic diseases, such as hyperlipidemia and diabetes...
  32. pmc CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe⁻(/)⁻ mice
    Daniel Kolbus
    Department of Clinical Sciences, Skåne University Hospital Malmö, Lund University, Sweden
    BMC Immunol 11:58. 2010
    It is well established that adaptive immune responses induced by hypercholesterolemia play an important role in the development of atherosclerosis, but the pathways involved remain to be fully characterized...
  33. ncbi Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial)
    Peter H Jones
    Baylor College of Medicine, 6565 Fannin Avenue, A 601, Houston, TX 77030, USA
    Am J Cardiol 92:152-60. 2003
    ..After a dietary lead-in period, 2,431 adults with hypercholesterolemia (LDL cholesterol > or =160 and <250 mg/dl; triglycerides <400 mg/dl) were randomized to treatment ..
  34. ncbi Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    P M Sullivan
    Department of Pathology and Laboratory of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    J Biol Chem 272:17972-80. 1997
    ..Thus the structural differences between human APOE3 and mouse ApoE proteins are sufficient to cause an increased susceptibility to dietary-induced hypercholesterolemia and atherosclerosis in the 3/3 mice.
  35. pmc A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol
    Ingrid K Kotowski
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, 75390 9046, USA
    Am J Hum Genet 78:410-22. 2006
    ..in the proprotein convertase subtilisin/kexin type 9 serine protease gene (PCSK9) cause autosomal dominant hypercholesterolemia, whereas nonsense mutations in the same gene are associated with low plasma levels of low-density ..
  36. ncbi Recommendations for the use of LDL apheresis
    G R Thompson
    Imperial College, Hammersmith Hospital, London
    Atherosclerosis 198:247-55. 2008
    ..3) LDL apheresis should also be considered for patients with aggressive progressing coronary disease and Lp(a)>60mg/l whose LDL cholesterol remains >3.2mmol/l despite maximal drug therapy...
  37. ncbi Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia
    Joseph Cheriyan
    Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Circulation 123:515-23. 2011
    ..We hypothesized that a selective p38α/β MAPK inhibitor (losmapimod; GW856553) would improve compromised nitric oxide-mediated vasoregulation in patients with hypercholesterolemia.
  38. pmc 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology
    Erik R Nelson
    Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA
    Science 342:1094-8. 2013
    b>Hypercholesterolemia is a risk factor for estrogen receptor (ER)-positive breast cancers and is associated with a decreased response of tumors to endocrine therapies...
  39. ncbi Serum total and lipoprotein cholesterol levels and awareness, treatment, and control of hypercholesterolemia in China
    Jiang He
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Ave SL18, New Orleans, LA 70112, USA
    Circulation 110:405-11. 2004
    Cardiovascular disease has become the leading cause of death in China. We examined the levels of serum total and lipoprotein cholesterol and status of awareness, treatment, and control of hypercholesterolemia in China.
  40. pmc Randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy
    Mary P McGowan
    Cardiometabolic Risk Reduction and Research Center of New England, Bedford, New Hampshire, United States of America
    PLoS ONE 7:e49006. 2012
    ..apolipoprotein B synthesis, significantly reduces LDL-C and other atherogenic lipoproteins in familial hypercholesterolemia when added to ongoing maximally tolerated lipid-lowering therapy...
  41. pmc Changes in fitness and fatness on the development of cardiovascular disease risk factors hypertension, metabolic syndrome, and hypercholesterolemia
    Duck Chul Lee
    Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, USA
    J Am Coll Cardiol 59:665-72. 2012
    ..study sought examine the independent and combined associations of changes in fitness and fatness with the subsequent incidence of the cardiovascular disease (CVD) risk factors of hypertension, metabolic syndrome, and hypercholesterolemia.
  42. pmc Diet-induced metabolic improvements in a hamster model of hypercholesterolemia are strongly linked to alterations of the gut microbiota
    Inés Martínez
    Department of Food Science and Technology, University of Nebraska, Lincoln, 68583 0919, USA
    Appl Environ Microbiol 75:4175-84. 2009
    ..the interplay among diet, gut microbial ecology, and cholesterol metabolism in a hamster model of hypercholesterolemia. Previous work in this model had shown that grain sorghum lipid extract (GSL) included in the diet ..
  43. pmc Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender
    Thiago M C Pereira
    Laboratory of Transgenes and Cardiovascular Control, Physiological Sciences Graduate Program, Health Sciences Center, Federal University of EspÃrito Santo, Av Marechal Campos 1468, Vitoria, ES 29043 900, Brazil
    Lipids Health Dis 9:87. 2010
    ..Our hypothesis was that advanced age-related cardiovascular changes are aggravated in atherosclerotic male mice...
  44. pmc Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats
    D Ehrlich
    Laboratory for Psychiatry and Exp Alzheimer s Research, Department of Psychiatry and Psychotherapy, Anichstr 35, 6020 Innsbruck, Austria
    Neuroscience 205:154-66. 2012
    ..Ethanol (EtOH) and cholesterol are such vascular risk factors, and we recently showed that hypercholesterolemia causes pathologies similar to AD [Ullrich et al. (2010) Mol Cell Neurosci 45, 408-417]...
  45. ncbi Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coin
    Daniel Steinberg
    University of California San Diego, La Jolla, CA 92093 0682, USA
    Mol Nutr Food Res 49:995-8. 2005
    ..clinical, and epidemiologic data capped by stunning interventional results with the statins has established hypercholesterolemia as a major causative factor in atherogenesis...
  46. ncbi Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor
    Alan Daugherty
    Division of Cardiovascular Medicine, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
    Circulation 110:3849-57. 2004
    b>Hypercholesterolemia-induced atherosclerosis is attenuated by either pharmacological antagonism of AT1 receptors or AT1A receptor deficiency...
  47. pmc Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies
    Eline Van Craeyveld
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    J Mol Med (Berl) 89:555-67. 2011
    ..In conclusion, drastic lipid lowering induced by a powerful gene transfer strategy leads to pronounced regression and stabilization of advanced murine atherosclerosis...
  48. ncbi Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia
    Nadia Reyna-Villasmil
    Center for Metabolic and Endocrine Research, The University of Zulia, Maracaibo, Venezuela
    Am J Ther 14:203-12. 2007
    To investigate the effect of bread formulated with 6 g of beta-glucan (oat soluble fiber) on serum lipids in overweight normotensive subjects with mild to moderate hypercholesterolemia.
  49. ncbi Current status of cholesterol goal attainment after statin therapy among patients with hypercholesterolemia in Asian countries and region: the Return on Expenditure Achieved for Lipid Therapy in Asia (REALITY-Asia) study
    Hyo Soo Kim
    Seoul National University Hospital, Seoul, South Korea
    Curr Med Res Opin 24:1951-63. 2008
    ..Data on achieving National Cholesterol Education Program Adult Treatment Panel III (ATP III) goals in Asia are limited...
  50. ncbi Elevated serum chemokine CXC ligand 5 levels are associated with hypercholesterolemia but not a worsening of insulin resistance in Chinese people
    Zhen Yang
    Institute of Endocrinology and Diabetology at Fudan University, Department of Endocrinology and Metabolism, Huashan Hospital affiliated with Fudan University, no 12 Wulumuqi Middle Road, Shanghai 200040, China
    J Clin Endocrinol Metab 95:3926-32. 2010
    ..Here we sought to evaluate serum CXCL5 distribution and its association with metabolic phenotypes among middle-aged and older Chinese...
  51. ncbi Efficacy and safety of ezetimibe added on to atorvastatin (20 mg) versus uptitration of atorvastatin (to 40 mg) in hypercholesterolemic patients at moderately high risk for coronary heart disease
    Scott E Conard
    University of Texas Southwestern Medical School, Dallas, TX, USA
    Am J Cardiol 102:1489-94. 2008
    ..ezetimibe 10 mg added to atorvastatin 20 mg compared with doubling atorvastatin to 40 mg in patients with hypercholesterolemia at moderately high risk for coronary heart disease who did not reach low-density lipoprotein (LDL) ..
  52. pmc Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits
    Celine Ullrich
    Laboratory of Psychiatry and Exp Alzheimers Research, Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Austria
    Mol Cell Neurosci 45:408-17. 2010
    ..The aim of our present work was to study the effects of hypercholesterolemia in adult rats...
  53. ncbi Trends in ATP-III-defined high blood cholesterol prevalence, awareness, treatment and control among U.S. adults
    Amanda D Hyre
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Ann Epidemiol 17:548-55. 2007
    ..We sought to determine trends in the prevalence, awareness, treatment and control of high low-density lipoprotein (LDL) cholesterol among U.S. adults...
  54. ncbi Enhanced renal cortical vascularization in experimental hypercholesterolemia
    Michael D Bentley
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Kidney Int 61:1056-63. 2002
    Experimental hypercholesterolemia is associated with pro-inflammatory changes and impaired regulation of tissue perfusion, which may lead to neovascularization. However, it is yet unknown whether such changes take place in the kidney...
  55. ncbi T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia
    S A Huber
    Department of Pathology, University of Vermont, Burlington, USA
    Circulation 103:2610-6. 2001
    T cells are implicated in atherosclerosis, but little is known about the genetic control or molecular pathways, especially under conditions of mild hypercholesterolemia.
  56. pmc Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia
    Huaizhu Wu
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 119:2708-17. 2009
    Monocyte activation and migration into the arterial wall are key events in atherogenesis associated with hypercholesterolemia. CD11c/CD18, a beta2 integrin expressed on human monocytes and a subset of mouse monocytes, has been shown to ..
  57. ncbi Efficacy and safety of ezetimibe coadministered with statins: randomised, placebo-controlled, blinded experience in 2382 patients with primary hypercholesterolemia
    M H Davidson
    Radiant Research, Chicago, IL 60610 4324, USA
    Int J Clin Pract 58:746-55. 2004
    ..from four similarly designed trials of ezetimibe coadministered with statins in 2382 patients with primary hypercholesterolemia. Patients were randomised to one of the following double-blind treatments for 12 weeks: placebo; ezetimibe ..
  58. ncbi Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime
    Daniel Steinberg
    Department of Medicine University of California San Diego, La Jolla, California, USA
    Nat Med 8:1211-7. 2002
  59. ncbi Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study
    Joel A Simon
    General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA
    Am J Cardiol 97:843-50. 2006
    ..The magnitude of the lipid and lipoprotein responses, however, differed among participants according to a number of phenotypic and demographic characteristics...
  60. ncbi Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circulation 115:377-86. 2007
    ..Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve stenosis...
  61. pmc Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia
    Elena Maganto-Garcia
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, NRB 7, Boston, MA 02115, USA
    Circulation 124:185-95. 2011
    Regulatory T cells (Treg) are present in atherosclerotic lesions and can modulate disease. In this study we characterized changes in Treg responses associated with prolonged hypercholesterolemia and lesion progression.
  62. pmc Contributions of a local health examination survey to the surveillance of chronic and infectious diseases in New York City
    R Charon Gwynn
    Mailman School of Public Health, Columbia University, 722 W 168th St, 13th Floor, New York, NY 10032, USA
    Am J Public Health 99:152-9. 2009
    ..We sought to evaluate the contribution of the New York City Health and Nutrition Examination Survey (NYC-HANES) to local public health surveillance...
  63. pmc Adding monounsaturated fatty acids to a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia
    David J A Jenkins
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, Ont, Canada
    CMAJ 182:1961-7. 2010
    ....
  64. ncbi Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice
    Sally Tandy
    Heart Research Institute, Sydney, Australia
    J Agric Food Chem 57:9339-45. 2009
    ....
  65. ncbi Human ApoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells
    Yingmei Feng
    Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:278-83. 2008
    ....
  66. ncbi Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials
    Kyoko Taku
    Information Center and the Nutritional Education Program, National Institute of Health and Nutrition, Tokyo, Japan
    Am J Clin Nutr 85:1148-56. 2007
    ..Clinical trials have reported the cholesterol-lowering effects of soy protein intake, but the components responsible are not known...
  67. ncbi Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia
    Alejandro R Chade
    Department of Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 64:962-9. 2003
    The potent vasoconstrictor endothelin-1 is involved in regulation of renal function, and is up-regulated in hypercholesterolemia (HC), a risk factor for renal disease that increases oxidative stress and impairs renal hemodynamic responses...
  68. ncbi HypoCol (red yeast rice) lowers plasma cholesterol - a randomized placebo controlled study
    Martin Prøven Bogsrud
    Lipid Clinic, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Scand Cardiovasc J 44:197-200. 2010
    ..The primary endpoint in our study was to investigate the effect of a red yeast rice (RYR) product on plasma lipids...
  69. ncbi LDL hypercholesterolemia is associated with accumulation of oxidized LDL, atherosclerotic plaque growth, and compensatory vessel enlargement in coronary arteries of miniature pigs
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Arterioscler Thromb Vasc Biol 18:415-22. 1998
    ....
  70. ncbi ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin
    B Tomlinson
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Pharmacol Ther 87:558-62. 2010
    ..In 305 Chinese patients with hypercholesterolemia who were treated with rosuvastatin at a dosage of 10 mg daily, the c...
  71. ncbi Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia
    J Goodfellow
    Cardiovascular Sciences Research Group, University of Wales College of Medicine, Cardiff, United Kingdom
    J Am Coll Cardiol 35:265-70. 2000
    This work was undertaken to determine whether dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia.
  72. ncbi Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers
    J Z Xiao
    Food Research and Development Laboratory, Morinaga Milk Industry Co, Ltd, Zama 228 8583, Japan
    J Dairy Sci 86:2452-61. 2003
    ..a particularly significant decrease in serum total cholesterol was found among subjects with moderate hypercholesterolemia (serum total cholesterol > 240 mg/dl)...
  73. ncbi Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction
    Dan Li
    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat Sen University, Guangzhou, Guangdong Province, 510080 People s Republic of China
    Arterioscler Thromb Vasc Biol 30:1354-62. 2010
    ..In this study, we examined whether the beneficial effects of AMPK on ECs are dependent on its involvement in cholesterol efflux and its impact on hypercholesterolemia-induced endothelial dysfunction.
  74. ncbi Circulating microparticles and endothelial progenitor cells in atherosclerosis: pharmacological effects of irbesartan
    A Georgescu
    Petru Poni Institute of Macromolecular Chemistry, Iasi, Romania
    J Thromb Haemost 10:680-91. 2012
    ....
  75. ncbi Effects of short- and long-term hypercholesterolemia on contrast-induced acute kidney injury
    Dingwei Yang
    Division of Nephrology, Department of Medicine, General Hospital of Tianjin Medical University, China
    Am J Nephrol 35:80-9. 2012
    Whether hypercholesterolemia is a risk factor for contrast-induced acute kidney injury (CI-AKI) remains unclear...
  76. ncbi Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice
    Audrey Chanet
    INRA, UMR 1019, UNH, CRNH Auvergne, F 63000 Clermont Ferrand, France
    J Nutr Biochem 23:469-77. 2012
    ..Thus, we aimed to investigate the antiatherogenic effects of NAR in different mouse models of hypercholesterolemia and decipher its molecular targets in the aorta using transcriptomic approach...
  77. ncbi Clinical aspects of PCSK9
    Bertrand Cariou
    INSERM, UMR915, l institut du thorax, F 44000 Nantes, France
    Atherosclerosis 216:258-65. 2011
    ..PCSK9 has emerged as a new pharmacological target for hypercholesterolemia, and different PCSK9 inhibitors are now evaluated in clinical trials...
  78. ncbi Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization: effects on endothelial progenitor cells and mature endothelial cells
    Paola Haddad
    Department of Cardiovascular Research Centre, Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    Atherosclerosis 217:340-9. 2011
    b>Hypercholesterolemia has been associated with impaired angiogenesis and reduced blood flow recuperation after ischemia. However, the precise mechanisms involved are unknown...
  79. ncbi Randomized head-to-head comparison of pitavastatin, atorvastatin, and rosuvastatin for safety and efficacy (quantity and quality of LDL): the PATROL trial
    Keijiro Saku
    Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Circ J 75:1493-505. 2011
    ..the safety and efficacy of atorvastatin, rosuvastatin and pitavastatin head to head in patients with hypercholesterolemia. This is the first prospective randomized multi-center trial to compare these strong statins (UMIN ..
  80. ncbi Comparative efficacy of the addition of ezetimibe to statin vs statin titration in patients with hypercholesterolaemia: systematic review and meta-analysis
    Dimitri P Mikhailidis
    Department of Clinical Biochemistry Vascular Disease Prevention Clinics, University College London UCL Medical School, London, UK
    Curr Med Res Opin 27:1191-210. 2011
    ..To systematically review and analyse evidence for cholesterol-lowering efficacy of at least 4 weeks of add-on ezetimibe vs doubling statin dose, in adults with primary hypercholesterolaemia...
  81. ncbi Deep-sea water improves cardiovascular hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits
    Shin Ichiro Katsuda
    Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    Biol Pharm Bull 31:38-44. 2008
    ..From our results, we conclude that deep-sea water could improve cardiovascular hemodynamics, even though the factors which affect the blood pressure are still unknown...
  82. pmc Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver
    Yan Liu
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School ofMedicine, Nashville, TN 37232, USA
    J Am Heart Assoc 2:e000093. 2013
    ..Elevated cholesterol and triglycerides in blood lead to atherosclerosis and fatty liver, contributing to rising cardiovascular and hepatobiliary morbidity and mortality worldwide...
  83. ncbi A meta-analysis evaluating the impact of chitosan on serum lipids in hypercholesterolemic patients
    William L Baker
    University of Connecticut School of Pharmacy, Storrs, CT, USA
    Ann Nutr Metab 55:368-74. 2009
    ..To better characterize the impact of chitosan on serum lipids in hypercholesterolemic patients, we performed a meta-analysis of randomized controlled trials...
  84. ncbi Nitric oxide pathway activation and impaired red blood cell deformability with hypercholesterolemia
    Taro Kuwai
    Department of General Medicine, School of Medicine, Kyorin University, Tokyo, Japan
    J Atheroscler Thromb 13:286-94. 2006
    ..oxide (NO)-mediated pathway on the deformability of red blood cells (RBC) were evaluated in the presence of hypercholesterolemia induced in rabbits fed a cholesterol-rich diet...
  85. ncbi Evaluation of vascular function in apolipoprotein E knockout mice with angiotensin-dependent renovascular hypertension
    Roberia M P Arruda
    Laboratory of Transgenes and Cardiovascular Control, Biomedical Center, Federal University of Espirito Santo, Brazil
    Hypertension 46:932-6. 2005
    ..The aim of this study was to evaluate the vascular function in a hypercholesterolemia/atherosclerosis model, in the angiotensin II-dependent 2-kidney 1-clip (2K1C) hypertension model and when ..
  86. pmc Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia
    Nathan O Stitziel
    From the Cardiovascular Division, Department of Medicine N O S and Division of Statistical Genomics N O S, Washington University School of Medicine, Saint Louis, MO Department of Vascular Medicine B S, S S, J J P K, G K H Department of Experimental Vascular Medicine S W F, J C D, and Radiology A J N, Academic Medical Center, Amsterdam, The Netherlands Center for Human Genetic Research, Boston, MA G M P, A M M, D A, S K Program in Medical and Population Genetics, Broad Institute, Cambridge, MA G M P, A M M, D A, S K Fred Hutchinson Cancer Research Center, Seattle, WA P L A, C K Wellcome Trust Centre for Human Genetics A G, M F, H W and Cardiovascular Medicine, Radcliffe Department of Medicine A G, M F, H W, University of Oxford, Oxford, United Kingdom Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Department of Medicine
    Arterioscler Thromb Vasc Biol 33:2909-14. 2013
    Autosomal recessive hypercholesterolemia is a rare inherited disorder, characterized by extremely high total and low-density lipoprotein cholesterol levels, that has been previously linked to mutations in LDLRAP1...
  87. pmc Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study
    C Cramer
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    Neurology 71:344-50. 2008
    ..This study aimed to test the association between use of statins and incidence of dementia and cognitive impairment without dementia (CIND) over 5 years of follow-up...
  88. pmc Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients
    Kwang Kon Koh
    Cardiology, Gil Medical Center, Gachon University, Incheon, Republic of Korea
    Atherosclerosis 204:483-90. 2009
    ..Therefore, we hypothesized that simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients...
  89. ncbi Downregulation of angiogenic factors and their downstream target molecules affects the deterioration of erectile function in a rat model of hypercholesterolemia
    Ji Kan Ryu
    Department of Urology, Clinical Research Center, Inha University School of Medicine, Jung Gu, Incheon, Republic of Korea
    Urology 67:1329-34. 2006
    To evaluate how the expression of angiogenic factors and their downstream target molecules, which are potentially involved in penile homeostasis, is related to erectile dysfunction in a rat model of hypercholesterolemia.
  90. ncbi Improved coronary vasodilatatory capacity by H.E.L.P. apheresis: comparing initial and chronic treatment
    Klaus P Mellwig
    Department of Cardiology, Nuclear Medicine and Molecular Imaging, Heart Center North Rhine Westphalia, Bad Oeynhausen, Germany
    Ther Apher Dial 10:510-7. 2006
    b>Hypercholesterolemia impairs endothelial function and subsequently decreases coronary vasodilatatory capacity. We examined the quantitative effects of one single LDL apheresis on vasodilatatory capacity...
  91. ncbi Korean red ginseng attenuates hypercholesterolemia-enhanced platelet aggregation through suppression of diacylglycerol liberation in high-cholesterol-diet-fed rabbits
    Seock Yeon Hwang
    Department of Clinical Laboratory Science, Juseong College, Cheongwongun, Chungbuk 363 794, Korea
    Phytother Res 22:778-83. 2008
    ..However, it is unclear whether KRG can attenuate hypercholesterolemia-enhanced platelet aggregation...
  92. ncbi Pitavastatin improves plasma pentraxin 3 and arterial stiffness in atherosclerotic patients with hypercholesterolemia
    Hiroyuki Ohbayashi
    Department of Internal Medicine, JA Gifu Tohno Kousei Hospital, Gifu, Japan
    J Atheroscler Thromb 16:490-500. 2009
    To investigate the effect of pitavastatin on asymptomatic atherosclerosis in patients with hypercholesterolemia.
  93. pmc High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
    Lakshmi Thirumangalakudi
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurochem 106:475-85. 2008
    Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer's disease-like dementia but the underlying mechanisms remain unknown...
  94. pmc Effects of hypertension and hypercholesterolemia on cognitive functioning in patients with alzheimer disease
    Felicia C Goldstein
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30329, USA
    Alzheimer Dis Assoc Disord 22:336-42. 2008
    This study investigated the relationship between the vascular comorbidities (VCs) of hypertension and hypercholesterolemia and the cognitive phenotype of Alzheimer disease (AD)...
  95. pmc Hypercholesterolemia impaired sperm functionality in rabbits
    Tania E Saez Lancellotti
    Laboratorio de Investigaciones Andrológicas de Mendoza, Facultad de Ciencias Medicas, Instituto de Histología y Embriología de Mendoza, Universidad Nacional de Cuyo, Centro Científico Tecnológico, Mendoza, Argentina
    PLoS ONE 5:e13457. 2010
    b>Hypercholesterolemia represents a high risk factor for frequent diseases and it has also been associated with poor semen quality that may lead to male infertility...
  96. pmc Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase
    Biljana Musicki
    Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 7:3023-32. 2010
    b>Hypercholesterolemia induces erectile dysfunction (ED) mostly by increasing oxidative stress and impairing endothelial function in the penis, but the mechanisms regulating reactive oxygen species (ROS) production in the penis are not ..
  97. ncbi Cardiovascular disease
    Elizabeth G Nabel
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 349:60-72. 2003
  98. ncbi Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia
    Fatima Akdim
    Department of Vascular Medicine, Academic Medical Center Amsterdam, Meibergdreef 9, PO Box 22660, 1100 DD, Amsterdam, The Netherlands
    Eur Heart J 32:2650-9. 2011
    ..A randomized, double-blind, placebo-controlled, dose-escalation study was designed to evaluate the efficacy and safety of mipomersen monotherapy with or without dose loading in subjects with mild-to-moderate hyperlipidaemia...
  99. ncbi Severe hypercholesterolaemia: therapeutic goals and eligibility criteria for LDL apheresis in Europe
    Gilbert R Thompson
    Imperial College, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 21:492-8. 2010
    ..On the basis of clinical experience, these patients tend to have the most severe forms of familial hypercholesterolaemia or markedly elevated LDL cholesterol (LDL-C) levels but are unable to tolerate statin therapy...
  100. pmc Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial
    Maartje E Visser
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur Heart J 33:1142-9. 2012
    ....
  101. pmc ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice
    Lisa A Cassis
    Rm 521b, Wethington Bldg, Graduate Center for Nutritional Sciences, Univ of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Heart Circ Physiol 296:H1660-5. 2009
    ..These results demonstrate that infusion of ANG II to hyperlipidemic mice induces AAAs and augments atherosclerosis independent of increased blood pressure...

Research Grants74

  1. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..in monocyte adhesion and recruitment into atherosclerotic lesions by using animal models of obesity with hypercholesterolemia, and by in vitro flow adhesion assay and in vivo adoptive transfer of blood monocytes with or without CD11c;..
  2. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..When we also observed that another mouse strain engineered to have hypercholesterolemia--apolipoprotein E (apoE) null mice--develop impaired lymphatic flow and dendritic cell (DC) migration ..
  3. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..Some diabetic complications are exacerbated by dyslipidemia. We discovered that hypercholesterolemia independently impairs TB defense...
  4. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2013
    ..metabolism and provide blueprints for drug discovery for major human diseases including diabetes, obesity, hypercholesterolemia, colon cancer, and chronic kidney disease, most of which represent a huge burden on public health...
  5. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda M Graham; Fiscal Year: 2013
    ..LysoPC inhibits EC migration in vitro, and hypercholesterolemia reduces EC migration into injured arteries and onto grafts...
  6. MOUSE MODEL FOR DISEASES OF PROTEIN MISFOLDING
    P Michael Conn; Fiscal Year: 2012
    ..cystic fibrosis, hypogonadotropic hypogonadism, nephrogenic diabetes insipidus, retinitis pigmentosa, hypercholesterolemia, cataracts, neurodegenerative diseases (Huntington's, Alzheimer's and Parkinson's), cancers ..
  7. Building Mouse Models of Metabolic Syndrome
    Karen L Svenson; Fiscal Year: 2013
    ..While the clustering of a subset of traits drawn from hypercholesterolemia, hypertriglyceridemia, reduced HDL-cholesterol, hypertension, obesity, and insulin resistance is a ..
  8. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
    ..bile acid induced diarrhea, while partial inhibition of ASBT-mediated transport can be used to treat hypercholesterolemia and cholestasis...
  9. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    ..improves endothelium-and eNOS-dependent vasodilation in two distinct murine models of vascular disease-hypercholesterolemia and sickle cell disease (SCD)...
  10. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012
    ..b) Women with endometriosis are at greater risk of hypertension, hypercholesterolemia, type 2 diabetes, myocardial infarction, and ischemic stroke...
  11. Risk factor-enhanced microvascular responses to ischemia-reperfusion.
    D Neil Granger; Fiscal Year: 2013
    ..increased by the presence of certain risk factors, such as hypertension (HTN), diabetes, obesity, and hypercholesterolemia (HCh), with combinations of risk factors exerting a synergistic effect on disease incidence...
  12. The altered lipid and protein metabolism of pediatric patients with HIV infection
    Farook Jahoor; Fiscal Year: 2010
    ..with lower lean body mass (LBM) and dyslipidemia, a syndrome characterized by hypertriglyceridemia and hypercholesterolemia. Although the clinical features of these metabolic derangements are described, their mechanistic ..
  13. HIGH SALT DIET, ANGIOTENSIN II, AND MICROVESSEL DILATION
    Julian H Lombard; Fiscal Year: 2012
    ..of pathological alterations seen in vascular diseases such as hypertension, atherosclerosis, and hypercholesterolemia. Impaired vascular function with high salt diet appears to be mediated by increased oxidative stress in the ..
  14. Structural Biology of the Apical Bile Acid Transporter.
    Peter W Swaan; Fiscal Year: 2012
    ..Additionally, it may aid future development of specific therapeutic strategies against hypercholesterolemia and related cardiovascular diseases...
  15. Chronic kidney disease in survivors of hematopoietic cell transplant
    Sangeeta Hingorani; Fiscal Year: 2012
    ..to determine if increased inflammation in conjunction with other cardiovascular risk factors such as hypercholesterolemia and hypertension, contribute to the increased risk of death in these patients...
  16. Role of Vascular Oxidative Stress in Obesity
    David G Harrison; Fiscal Year: 2013
    ..Obesity is associated with conditions like hypertension, hypercholesterolemia and diabetes. Experimental studies have shown that these diseases promote vascular ROS production...
  17. iPS-derived hepatocytes as a model of familial hypercholesterolemia
    Max A Cayo; Fiscal Year: 2013
    ..Familial hypercholesterolemia (FH) is a common (1:500) inherited hyperlipidemia caused by mutations in the LDL receptor (LDLR)...
  18. Induced Pluripotent Stem Cells from Swine: application to genetic modification
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..Loss of function of LDLR in humans causes hypercholesterolemia, coronary heart disease, and onset of the so-called metabolic syndrome...
  19. Characterization of Diet1, a hypercholesterolemia resistance gene
    Karen Reue; Fiscal Year: 2013
    ..cloning, we have identified the Diet1 gene from an inbred mouse strain that is resistant to diet-induced hypercholesterolemia and atherosclerosis...
  20. miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
    Yun Fang; Fiscal Year: 2012
    ..The research proposal tests the overall hypothesis that flow and/or hypercholesterolemia-sensitive miR-10a dynamically modulates endothelial phenotypes in the initiation and progression of ..
  21. Endoplasmic reticulum stress and foam cell formation
    Zhongmao Guo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Individuals with apolipoprotein (Apo) E deficiency develop hypercholesterolemia and atherosclerosis...
  22. Regulation of Endothelial Nitric Oxide Synthase mRNA stability
    Jianxin Sun; Fiscal Year: 2013
    ..and whether eEF1A1 and PTB participate in the development of endothelial dysfunction in a rabbit model of hypercholesterolemia. These proposed studies will provide greater insights into the mechanisms of how eNOS expression is ..
  23. The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Can
    George Thomas; Fiscal Year: 2013
    ..ketogenic diet, and dietary constituents or caloric intake in PCa development;(ii) test the hypothesis that hypercholesterolemia promotes PCa progression and that it is related to dysfunctional feedback regulation of the low-density ..
  24. Cholesterol and Prostate Health
    Michael R Freeman; Fiscal Year: 2013
    ..Our data suggest that hypercholesterolemia may predispose to prostate pathology...
  25. Vascular Mechanisms in Homocysteinemia and Atherosclerosis
    Steven R Lentz; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hyperhomocysteinemia and hypercholesterolemia are common cardiovascular risk factors that often occur together in patients with vascular thrombotic events...
  26. Health benefits of vigorous exercise in middle-aged versus older men and women
    Paul T Williams; Fiscal Year: 2010
    ..of vigorous physical activity and cardiorespiratory fitness on the incidence of diabetes, hypertension, hypercholesterolemia, arthritis, and other chronic conditions in relation to age in a large prospective epidemiological cohort ..
  27. Discovery of Mendelian Dyslipidemia and Heart Attack Genes Using Exome Sequencing
    Sekar Kathiresan; Fiscal Year: 2013
    ..out;(2) To perform sequencing of the exome in 2-4 affected individuals from each of 10 families with severe hypercholesterolemia and discover the causal gene and mutation specific to each family...
  28. Targeting PCSK9 Transcription to Combat Hypercholesterolemia by Berberine
    Jingwen Liu; Fiscal Year: 2013
    ..to selectively repress PCSK9 expression without diminishing LDLR transcription for the treatment of hypercholesterolemia and heart disease...
  29. Molecular Basis of Autosomal Dominant Hypercholesterolemia in a Multiethnic Cohor
    Zahid Ahmad; Fiscal Year: 2013
    PROJECT DESCRIPTION: Autosomal dominant hypercholesterolemia (ADH) is a dominantly inherited disorder present from birth that causes marked elevation in plasma low-density lipoprotein cholesterol (LDL-C) and premature coronary heart ..
  30. Regulation of Hepatic P450s by Anti-Cholesterol Drugs
    Thomas A Kocarek; Fiscal Year: 2013
    ..approach for reducing the risk of developing coronary heart disease, and since behaviors that promote hypercholesterolemia are prevalent, statins are consumed by many people...
  31. PARASYMPATHETIC DYSFUNCTION IN OBESITY: EFFECT OF CHOLESTEROL ON VAChT
    Yifan Li; Fiscal Year: 2013
    ..High plasma cholesterol (hypercholesterolemia) affects neurons in the brain14-16 but its effect on the peripheral cholinergic system is unknown...
  32. Role of the MC3-R in Obesity and Metabolic Syndrome
    Roger D Cone; Fiscal Year: 2012
    ..however, in the MC4-R null mouse this increase in percentage body fat is accompanied by hyperinsulinemia, hypercholesterolemia, proinflammatory changes, and lipotoxicity of the liver, or hepatic steatosis, while the MC3-R null appears ..
  33. An immunoadhesin for treatment of hypercholesterolemia
    KEITH WYCOFF; Fiscal Year: 2012
    ..Statins are widely prescribed as therapy for hypercholesterolemia (high cholesterol)...
  34. Drosophila feeding behavior: New tools for the genetic dissection of prandiology
    William W Ja; Fiscal Year: 2012
    ..has been neglected, despite the possible role played by prandial habits in the physiopathology of obesity, hypercholesterolemia, and diabetes...
  35. Epigenomic impact of diet and toxicant exposure in Alzheimers disease etiology
    Iliya Lefterov; Fiscal Year: 2013
    ..Importantly, some metabolic stimuli, like hypercholesterolemia, obesity, hyperinsulinemia and insulin resistance, follow certain dietary patterns and lifestyle, and are ..
  36. Oxysterols, Estrogen Receptor Antagonism, and Vascular Disease
    Philip W Shaul; Fiscal Year: 2013
    ..In the current funding period we identified 27-hydroxycholesterol (27HC), which is elevated with hypercholesterolemia, as the first endogenous selective estrogen receptor modulator (SERM)...
  37. Does Diabetic Hyperglycemia Regulate Atherosclerosis Progression and Regression?
    ROBERT RAFFAI; Fiscal Year: 2013
    ..chow diet, these mice, while moderately dyslipidemic, are resistant to further hyperglycemia-induced hypercholesterolemia. Moreover, they develop occlusive peripheral atherosclerosis by 12 to 14 months of age, predisposing to ..
  38. MOLECULAR REGULATION OF FXR ACTIVITY
    Jongsook Kim Kemper; Fiscal Year: 2010
    ..the development of novel therapeutic agents for metabolic disorders, such as fatty liver (liver steatosis), hypercholesterolemia, and diabetes...
  39. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2012
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis.
  40. MOLECULAR BASIS OF CHOLESTEROL METABOLISM
    Joseph L Goldstein; Fiscal Year: 2013
    ..pathway for control of cholesterol metabolism and showed that defects in the LDL receptor produce Familial Hypercholesterolemia and atherosclerosis...
  41. Exploring statins as a small molecule therapy for treatment of schistosomiasis
    Conor Caffrey; Fiscal Year: 2013
    ..cdipd.org) has identified commercial anti-hypercholesterolemia statin drugs - inhibitors of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) - as ..
  42. Designing HIV Protease Inhibitors with Lower Dosing Requirements and Lower Toxici
    Mitchell W Mutz; Fiscal Year: 2013
    ..with other HIV protease inhibitors (PI's) include hepatotoxicity, carotid artery thickening, hypercholesterolemia, hyperglycemia, and lipodystrophy...
  43. Cholesterol induces oxidative stress and triggers iron and A? accumulation
    Othman Ghribi; Fiscal Year: 2012
    ..b>Hypercholesterolemia is a potential risk factors for AD...
  44. Real-time microviscosity measurement tools for the cell
    Mark A Haidekker; Fiscal Year: 2010
    ..g. altered membrane viscosity related to atherosclerosis, cell malignancy, hypercholesterolemia, and diabetes)...
  45. Genetic determinants of total cholesterol levels in American Indians
    JOHANNA K DISTEFANO; Fiscal Year: 2013
    ..The goal of this study is to advance our knowledge of common lipid abnormalities, such as hypercholesterolemia, through the identification and characterization of genes that have been linked to chromosome 19 in a ..
  46. PROTEOLYSIS OF HMW FGF-2 BY THROMBIN AND ITS CARDIOVASCULAR IMPLICATIONS
    Giuseppe Pintucci; Fiscal Year: 2010
    ..as nitric oxide synthesis, and its serum levels, elevated in diabetes, renal failure, hypertension, and hypercholesterolemia, correlate with a poor prognosis in cardiovascular patients...
  47. Regulation of Intestinal Bile Acid Transport
    Waddah A Alrefai; Fiscal Year: 2013
    ..of these inhibitory pathways is crucial to exploit their utilization as an effective therapy for hypercholesterolemia associated with diabetes mellitus...
  48. BIOBEHAVIORAL RESEARCH IN PUBLIC HEALTH GENETICS
    KENNETH TERCYAK; Fiscal Year: 2011
    ..results from a panel of 15 genetic markers for 8 health conditions (diabetes, osteoporosis, heart disease, hypercholesterolemia, high blood pressure, and lung, colon, and skin cancer), and discussion of its implications for family ..
  49. 27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis
    ERIK RUSSELL NELSON; Fiscal Year: 2013
    ..ERs and liver X receptors (LXRs), suggests a potential, heretofore unrecognized, mechanistic link between hypercholesterolemia and breast cancer incidence...
  50. DNA VIRUS AS VECTORS FOR CARDIOVASCULAR DISEASES
    James M Wilson; Fiscal Year: 2013
    ..pre-clinical development of gene therapy to liver for the treatment of two severe dyslipidemias: familial hypercholesterolemia (FH) and abetalipoproteinemia (ABL)...
  51. Role of PDZK1 in lipid metabolism and atherosclerosis
    Olivier N Kocher; Fiscal Year: 2013
    ..PDZK1 joins ARH (the product of the defective gene in autosomal recessive hypercholesterolemia) in what is likely to be a growing family of cytoplasmic adaptor proteins that control the tissue specific ..
  52. Stress Hormones and Chondrogenic Vascular Calcification
    JODI FRANCES EVANS; Fiscal Year: 2013
    ..the C57BL/6 and L-PGDS KO mice confirms the hypothesized connection between diet-induced hyperglycemia and hypercholesterolemia and hyper-activity of the hypothalamic-pituitary adrenal axis...
  53. Cholesterol Homeostasis in Auditory Function
    MICHELLE LYNN SEYMOUR; Fiscal Year: 2013
    ..Although animal models and human studies support a link between hypercholesterolemia and sensorineural hearing loss that implicates pathologies affecting the cochlea, auditory nerve and/or ..
  54. miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
    Yun Fang; Fiscal Year: 2013
    ..The research proposal tests the overall hypothesis that flow and/or hypercholesterolemia-sensitive miR-10a dynamically modulates endothelial phenotypes in the initiation and progression of ..
  55. Physical Activity and Diet in the Prevention of Obesity in Men and Women
    Howard D Sesso; Fiscal Year: 2010
    ..are modified by the presence or absence of intermediate clinical factors such as hypertension, diabetes, hypercholesterolemia, or parental history of obesity (available in men only)...
  56. Scalable Production of New Generation Adeno-Associated Virus Gene Therapy Vectors
    MARTIN W LOCK; Fiscal Year: 2010
    ..vector bearing a human low density lipoprotein receptor (hLDLR) transgene for the treatment of familial hypercholesterolemia (FH)...
  57. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda Graham; Fiscal Year: 2009
    ..LysoPC inhibits EC migration in vitro, and hypercholesterolemia reduces EC migration into injured arteries and onto grafts...
  58. Pathogenesis of Dyslipidemia and Atherosclerosis in the Diabetic State
    Sudha B Biddinger; Fiscal Year: 2013
    ..and in vivo models and that diabetic mice show increased Mylip expression, reduced LDL receptor protein and hypercholesterolemia. Based on this, we hypothesize that insulin suppresses Mylip transcription and that increased Mylip in the ..
  59. Web-based, Patient-centered Approach to CVD Risk-factor Management and Reduction
    Jeffrey A Henderson; Fiscal Year: 2010
    ..and behavioral instructions they have been given to manage, respectively, their diagnosed hypertension, hypercholesterolemia, and diabetes; 2...
  60. Clathrin-coated vesicles and endocytic function
    Linton M Traub; Fiscal Year: 2013
    ..Defects in clathrin- mediated endocytosis are linked to several important human disease states, from hypercholesterolemia and certain cancers to Alzheimer disease...
  61. Mechanisms for Dysfunctional HDL Formation in Familial Hypercholesterolemia
    Macrae F Linton; Fiscal Year: 2013
    ..Familial hypercholesterolemia (FH) is an autosomal dominant disorder associated with severely elevated LDL levels and increased risk of ..
  62. Proteolysis of ultralarge von Willebrand factor and metabolic syndrome-diabetes
    Jing Fei Dong; Fiscal Year: 2011
    ..The decrease is also observed in mice with hypercholesterolemia. We further find that ADAMTS-13 synthesis is severely reduced in the liver of diabetic mice...
  63. REGULATION OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 1999
    ..Alterations of this mechanism could lead to pathological conditions such as hypercholesterolemia, atherosclerosis, cholelithiasis, sterol storage diseases and liver diseases in humans...
  64. MOLECULAR PHYSIOLOGY OF BILIARY LIPID SECRETION
    David Cohen; Fiscal Year: 2000
    ..and abnormalities in bile secretion may result in gallstone formation, cholestasis, biliary cirrhosis, hypercholesterolemia and fat malabsorption...
  65. THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSIS
    William Boisvert; Fiscal Year: 2002
    ..Mice will be fed a chow or high cholesterol diet to define the role of mIL-8RH in mild vs. severe hypercholesterolemia-induced atherosclerosis...
  66. CHOLESTEROL TREATMENT MODEL FOR LOW INCOME PATIENTS
    Ross Simpson; Fiscal Year: 1993
    ..of a structured treatment program (Assist Model) designed to improve primary care management of hypercholesterolemia in community health centers...
  67. Nutrition Intervention: Metabolic Complications of HIV+
    Margo Woods; Fiscal Year: 2006
    ..Elevated triglycerides are a common observation with or without hypercholesterolemia. Since statin do not reduce serum triglycerides and may be counter-indicated to lower serum cholesterol ..
  68. APOLIPOPROTEIN E BINDING TO RECEPTORS
    David Chappell; Fiscal Year: 1991
    ..This is the case in two hereditary disorders, familial hypercholesterolemia, in which the apo-B,E(LDL) receptor is defective, and familial dysbetalipoproteinemia (type III ..
  69. Therapeutic Angiogenesis for Erectile Dysfunction
    BRIAN ANNEX; Fiscal Year: 2009
    ..b>Hypercholesterolemia is one of the strongest risk factors for the development of ED...
  70. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
    ..multidisciplinary clinical research outlined in this application is to test the hypothesis that in humans hypercholesterolemia (and other forms of hyperlipidemia) are associated with blunted skeletal muscle vasodilator responses to ..
  71. Nox Isoforms and Vascular Cell Phenotype
    John Keaney; Fiscal Year: 2009
    ..Despite considerable interest in specific cardiovascular risk factors such as hypercholesterolemia, diabetes, and hypertension, data from the Framingham Heart Study indicate clearly the main determinant of ..
  72. REGULATION OF LDL RECEPTORS IN ADIPOCYTES
    FREDRIC KRAEMER; Fiscal Year: 1993
    Obesity appears to be an independent risk factor for cardiovascular disease and to be interrelated with hypercholesterolemia. While much progress has been made in elucidating the pathways regulating cholesterol uptake and storage in most ..
  73. Novel Modulators of LDL Metabolism
    Nabil Elshourbagy; Fiscal Year: 2009
    ..Furthermore, patients with homozygous familial hypercholesterolemia who have markedly elevated cholesterol levels respond poorly to current drug therapy, and are at high risk ..
  74. NITRIC OXIDE/SUPEROXIDE IN LIPID VASCULAR DISEASE
    TIMOTHY O BRIEN; Fiscal Year: 2000
    ..from Investigator's Abstract): Atherosclerosis is a leading cause of death in the Western world, and hypercholesterolemia is a well-known risk factor for its development...