cerebral amyloid angiopathy

Summary

Summary: A heterogeneous group of disorders that includes sporadic and familial forms, characterized clinically by cerebral ischemia (see BRAIN ISCHEMIA); CEREBRAL INFARCTION; and CEREBRAL HEMORRHAGE. Pathologically the condition is marked by the deposition of AMYLOID in the walls of small blood vessels in the cerebral cortex and meninges. The sporadic form is associated with lobar cerebral hemorrhage in the elderly and ALZHEIMER DISEASE. (From Neuropathol Appl Neurobiol 1996 Jun;22(3):216-227; Adams et al., Principles of Neurology, 6th ed, p852)

Top Publications

  1. ncbi Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
  2. ncbi APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
    Anne Rovelet-Lecrux
    Inserm U614 IFRMP, Faculty of Medicine, Rouen, France
    Nat Genet 38:24-6. 2006
  3. ncbi APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
    Kristel Sleegers
    Neurodegenerative Brain Diseases Group Antwerp, Belgium
    Brain 129:2977-83. 2006
  4. ncbi Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy
    Anika M S Hartz
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA
    Stroke 43:514-23. 2012
  5. pmc Innate immunity receptor CD36 promotes cerebral amyloid angiopathy
    Laibaik Park
    Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:3089-94. 2013
  6. ncbi Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease
    Elissa M Robbins
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:365-71. 2006
  7. pmc Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    Robert D Bell
    Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Acta Neuropathol 118:103-13. 2009
  8. ncbi Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria
    K A Knudsen
    Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Neurology 56:537-9. 2001
  9. pmc Abeta42 is essential for parenchymal and vascular amyloid deposition in mice
    Eileen McGowan
    Department Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neuron 47:191-9. 2005
  10. ncbi Review: sporadic cerebral amyloid angiopathy
    J Attems
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 37:75-93. 2011

Detail Information

Publications271 found, 100 shown here

  1. ncbi Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    Cerebrovascular deposition of beta-amyloid (cerebral amyloid angiopathy [CAA]) is a major cause of hemorrhagic stroke and a likely contributor to vascular cognitive impairment...
  2. ncbi APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
    Anne Rovelet-Lecrux
    Inserm U614 IFRMP, Faculty of Medicine, Rouen, France
    Nat Genet 38:24-6. 2006
    ..on chromosome 21 in five families with autosomal dominant early-onset Alzheimer disease (ADEOAD) and cerebral amyloid angiopathy (CAA). Among these families, the duplicated segments had a minimal size ranging from 0.58 to 6.37 Mb...
  3. ncbi APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
    Kristel Sleegers
    Neurodegenerative Brain Diseases Group Antwerp, Belgium
    Brain 129:2977-83. 2006
    ..In this family, cerebral amyloid angiopathy (CAA) coincided with this disease...
  4. ncbi Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy
    Anika M S Hartz
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA
    Stroke 43:514-23. 2012
    b>Cerebral amyloid angiopathy (CAA) is a degenerative disorder characterized by amyloid-β (Aβ) deposition in the blood-brain barrier (BBB)...
  5. pmc Innate immunity receptor CD36 promotes cerebral amyloid angiopathy
    Laibaik Park
    Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:3089-94. 2013
    Deposition of amyloid-β (Aβ) in cerebral arteries, known as cerebral amyloid angiopathy (CAA), occurs both in the setting of Alzheimer's disease and independent of it, and can cause cerebrovascular insufficiency and cognitive deficits...
  6. ncbi Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease
    Elissa M Robbins
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:365-71. 2006
    b>Cerebral amyloid angiopathy (CAA), the deposition of cerebrovascular beta-amyloid (Abeta) in the walls of arterial vessels, has been implicated in hemorrhagic stroke and is present in most cases of Alzheimer disease...
  7. pmc Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    Robert D Bell
    Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA
    Acta Neuropathol 118:103-13. 2009
    ..The accumulation of Abeta on the cerebral blood vessels, known as cerebral amyloid angiopathy (CAA), is associated with cognitive decline and is one of the hallmarks of AD pathology...
  8. ncbi Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria
    K A Knudsen
    Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Neurology 56:537-9. 2001
    ..performed clinical-pathologic correlation to assess the validity of the Boston diagnostic criteria for cerebral amyloid angiopathy (CAA)...
  9. pmc Abeta42 is essential for parenchymal and vascular amyloid deposition in mice
    Eileen McGowan
    Department Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neuron 47:191-9. 2005
    ..These data establish that Abeta1-42 is essential for amyloid deposition in the parenchyma and also in vessels...
  10. ncbi Review: sporadic cerebral amyloid angiopathy
    J Attems
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 37:75-93. 2011
    b>Cerebral amyloid angiopathy (CAA) may result from focal to widespread amyloid-β protein (Aβ) deposition within leptomeningeal and intracortical cerebral blood vessels...
  11. pmc Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy
    Cheryl A Hawkes
    Centre for Research in Neurodegenerative, University of Toronto, Toronto, Ontario, Canada M5S 3H2
    Proc Natl Acad Sci U S A 106:1261-6. 2009
    b>Cerebral amyloid angiopathy (CAA), the deposition of beta-amyloid (Abeta) peptides in leptomeningeal and cortical blood vessels, affects the majority of patients with Alzheimer's disease (AD)...
  12. pmc Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Coleman Pavilion, Suite 11113, 11175 Campus St, Loma Linda, CA 92350, USA
    Acta Neuropathol 119:291-302. 2010
    ..significance of these lesions remains uncertain, their distribution and prevalence correlates with cerebral amyloid angiopathy (CAA), hypertension, smoking, and cognitive deficits...
  13. ncbi Immunotherapy reduces vascular amyloid-beta in PDAPP mice
    Sally Schroeter
    Elan Pharmaceuticals, South San Francisco, California 94080, and Wyeth Pharmaceuticals, Cambridge, Massachusetts 02140, USA
    J Neurosci 28:6787-93. 2008
    ..Abeta) plaques, Alzheimer's disease (AD) is characterized by Abeta in the cerebral vasculature [cerebral amyloid angiopathy (CAA)] in the majority of patients...
  14. ncbi Cerebral amyloid angiopathy and its relationship to Alzheimer's disease
    Dietmar Rudolf Thal
    Laboratory of Neuropathology, Institute of Pathology, University of Ulm, Albert Einstein Allee 7, 89081 Ulm, Germany
    Acta Neuropathol 115:599-609. 2008
    b>Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid beta-protein (A beta) within cerebral vessels...
  15. pmc Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice
    Tom van Dooren
    Department Human Genetics, Experimental Genetics Group, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Pathol 168:245-60. 2006
    ..Neuronal and glial ApoE4 promoted cerebral amyloid angiopathy as extensively as mutant PS1 but with pronounced regional differences: cortical angiopathy was induced ..
  16. ncbi Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum
    Andreas Charidimou
    Stroke Research Group, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 83:124-37. 2012
    Sporadic cerebral amyloid angiopathy (CAA) is a common age related cerebral small vessel disease, characterised by progressive deposition of amyloid-β (Aβ) in the wall of small to medium sized arteries, arterioles and capillaries of ..
  17. ncbi Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy
    M E Gurol
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 66:23-9. 2006
    ..Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease...
  18. ncbi Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy
    Zoë van Helmond
    Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Bristol, UK
    Brain Pathol 20:468-80. 2010
    ..that was labeled in the sections correlated with total Abeta plaque load, but not phospho-tau load, cerebral amyloid angiopathy (CAA) severity or APOE genotype...
  19. pmc Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts
    Yoko Okamoto
    Department of Neurology, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo, Kyoto 606 8507, Japan
    Acta Neuropathol 123:381-94. 2012
    ..in brains of patients with Alzheimer's disease tend to be located close to vessels afflicted with cerebral amyloid angiopathy (CAA)...
  20. ncbi Tissue transglutaminase colocalizes with extracellular matrix proteins in cerebral amyloid angiopathy
    Mieke de Jager
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:1159-69. 2013
    b>Cerebral amyloid angiopathy (CAA) is a key histopathological hallmark of Alzheimer's disease (AD) and hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D)...
  21. ncbi Cerebral amyloid angiopathy
    Masahito Yamada
    Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Prog Mol Biol Transl Sci 107:41-78. 2012
    b>Cerebral amyloid angiopathy (CAA) is cerebrovascular amyloid deposition...
  22. pmc Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy
    J Linn
    Department of Neuroradiology, University Hospital Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Neurology 74:1346-50. 2010
    b>Cerebral amyloid angiopathy (CAA) typically presents with lobar intracerebral macrohemorrhages (ICH) or microbleeds (MBs). Several case reports also found superficial siderosis (SS) in patients with CAA...
  23. pmc Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice
    Takashi Mori
    Department of Biomedical Sciences, Saitama Medical Center and University, Kawagoe, Saitama 350 8550, Japan
    J Biol Chem 287:6912-27. 2012
    ..Taken together, these results raise the possibility that dietary supplementation with TA may be prophylactic for AD by inhibiting β-secretase activity and neuroinflammation and thereby mitigating AD pathology...
  24. ncbi Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
    Cheryl A Hawkes
    Division of Clinical Neurosciences, Southampton General Hospital, University of Southampton, South Lab and Pathology Block, LD66 Mailpoint 806, Tremona Road, Southampton, Hampshire, SO166YD, UK
    Acta Neuropathol 121:431-43. 2011
    The deposition of amyloid-β (Aβ) peptides in the walls of leptomeningeal and cortical blood vessels as cerebral amyloid angiopathy (CAA) is present in normal ageing and the majority of Alzheimer's disease (AD) brains...
  25. ncbi Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy
    Roy O Weller
    Clinical Neurosciences, University of Southampton School of Medicine, LD74, South Laboratory and Pathology Block, Southampton General Hospital, Southampton SO166YD, UK
    Acta Neuropathol 118:87-102. 2009
    ..Accumulation of Abeta as plaques in brain parenchyma and artery walls as cerebral amyloid angiopathy (CAA) is associated with failure of perivascular elimination of Abeta from the brain in the elderly and ..
  26. pmc Beta-amyloid, blood vessels, and brain function
    Eric E Smith
    Division of Neurology, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 40:2601-6. 2009
    ..Vascular beta-amyloid deposition, also known as cerebral amyloid angiopathy, is associated with vascular dysfunction in animal and human studies...
  27. ncbi Towards defining the neuropathological substrates of vascular dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 226:75-80. 2004
    ..Similar to other common dementias consensus criteria for VaD need unambiguous definition to impact on preventative and treatment strategies and are critical for selective recruitment to clinical trials...
  28. pmc Progression of white matter lesions and hemorrhages in cerebral amyloid angiopathy
    Y W Chen
    Department of Neurology, Li Shin Hospital and National Taiwan University Hospital, Taipei
    Neurology 67:83-7. 2006
    To determine the rate of progression of white matter lesions and hemorrhages in a cohort with cerebral amyloid angiopathy (CAA).
  29. pmc Cognitive impact of subcortical vascular and Alzheimer's disease pathology
    Helena C Chui
    Department of Neurology, University of Southern California, Los Angeles, USA
    Ann Neurol 60:677-87. 2006
    ..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype...
  30. ncbi 11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage
    J V Ly
    National Stroke Research Institute, Level 1, Neurosciences Building, Austin Health, University of Melbourne, 300 Waterdale Rd, Heidelberg Heights, Victoria 3081, Australia
    Neurology 74:487-93. 2010
    The in vivo diagnosis of cerebral amyloid angiopathy (CAA) is inferred from clinical and structural imaging features. (11)C-Pittsburgh compound B (PIB) is a PET ligand that binds to beta-amyloid in extracellular plaques and vessel walls...
  31. ncbi Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta
    Margaret M Racke
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 25:629-36. 2005
    ..directed against the N terminus of amyloid beta (Abeta) has recently been reported to exacerbate cerebral amyloid angiopathy (CAA)-related microhemorrhage in a transgenic animal model...
  32. pmc Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid
    M E Calhoun
    Department of Neuropathology, Institute for Pathology, University of Basel, CH 4003 Basel, Switzerland
    Proc Natl Acad Sci U S A 96:14088-93. 1999
    ..Here, we describe significant deposition of amyloid beta (Abeta) in the cerebral vasculature [cerebral amyloid angiopathy (CAA)] in aging APP23 mice that had striking similarities to that observed in human aging and Alzheimer'..
  33. pmc Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease
    D M Wilcock
    Duke University Medical Center, Division of Neurology, Bryan Research Building, Box 2900, Research Drive, Durham, NC 27710, USA
    Neuroscience 159:1055-69. 2009
    ..A significant proportion of individuals with Alzheimer's disease (AD) have vascular amyloid deposits (cerebral amyloid angiopathy, CAA) that contribute to the heterogeneous nature of the disease...
  34. ncbi Clinical manifestations of cerebral amyloid angiopathy-related inflammation
    Jessica A Eng
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 55:250-6. 2004
    ..of the amyloid beta peptide (A beta), we analyzed 42 consecutive patients with pathologically diagnosed cerebral amyloid angiopathy (CAA) for evidence of an inflammatory response...
  35. ncbi Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
    John D Fryer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:2803-10. 2005
    ..in the extracellular spaces of the brain as parenchymal plaques and in the walls of cerebral vessels as cerebral amyloid angiopathy (CAA). CAA is a common cause of brain hemorrhage and is found in most patients with AD...
  36. pmc Cortical superficial siderosis and intracerebral hemorrhage risk in cerebral amyloid angiopathy
    Andreas Charidimou
    From the Stroke Research Group, Department of Brain Repair and Rehabilitation A C, D J W, and Lysholm Department of Neuroradiology R J, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK Department of Neurology A P P, Cliniques Universitaires UCL Saint Luc, Brussels, Belgium Department of Brain Repair and Rehabilitation R J, and Biomedical Research Centre, UCL and the Education Unit Z F, UCL Institute of Neurology, Queen Square, London, UK Department of Neurology, CHU Mont Godinne Y V, P L, and Institute of Neuroscience Y V, P L, Universite Catholique de Louvain, Brussels, Belgium Department of Clinical Neurosciences J C B, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK and UMR 894 INSERM Université Paris 5, Sorbonne Paris Cité, Paris, France
    Neurology 81:1666-73. 2013
    ..whether cortical superficial siderosis (cSS) on MRI, especially if disseminated (involving more than 3 sulci), increases the risk of future symptomatic lobar intracerebral hemorrhage (ICH) in cerebral amyloid angiopathy (CAA).
  37. pmc Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease
    Terry L Lewis
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:36958-68. 2010
    ..were found in the total level and deposition of Aβ in the brains of APP/PS1 and APP/PS1/AI mice, but cerebral amyloid angiopathy was reduced in APP/PS1/AI mice...
  38. ncbi Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy
    David T Winkler
    Department of Neuropathology, Institute of Pathology, University Hospital Basel, Schonbeinstrasse 40, CH 4003 Basel, Switzerland
    Ann Neurol 51:790-3. 2002
    We studied the impact of cerebral amyloid angiopathy on tissue plasminogen activator-induced cerebral hemorrhages in APP23 transgenic mice...
  39. pmc Is Alzheimer's disease amyloidosis the result of a repair mechanism gone astray?
    Tyler A Kokjohn
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 8:574-83. 2012
    ..Successful application of AD preventative approaches may hinge on an accurate and comprehensive view of comorbidities, including cardiovascular disease, diabetes, and head trauma...
  40. pmc Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy
    Byung Hee Han
    Department of Neurological Surgery, Washington University School of Medicine, St, Louis, MO 63110, USA
    Mol Neurodegener 6:86. 2011
    b>Cerebral amyloid angiopathy (CAA) is characterized by deposition of fibrillar amyloid β (Aβ) within cerebral vessels. It is commonly seen in the elderly and almost universally present in patients with Alzheimer's Disease (AD)...
  41. ncbi Interest of CSF biomarker analysis in possible cerebral amyloid angiopathy cases defined by the modified Boston criteria
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Place du Pr DEBRE, 30029, Nimes Cedex 9, France
    J Neurol 259:2429-33. 2012
    According to the modified Boston criteria, cerebral amyloid angiopathy (CAA) can present with lobar hematoma (LH) or superficial siderosis (SS)...
  42. pmc Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy
    Edward K Agyare
    Division of Pharmaceutical Sciences, College of Pharmacy, Florida A and M University, 228 Dyson Building, Tallahassee, FL 32307, USA
    Pharm Res 25:2674-84. 2008
    ..To design a smart nano-vehicle (SNV) capable of permeating the blood-brain barrier (BBB) to target cerebrovascular amyloid formed in both Alzheimer's disease (AD) and cerebrovascular amyloid angiopathy (CAA)...
  43. pmc Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy
    A Biffi
    Department of Neurology and Hemorrhagic Stroke Research Program, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Neurology 75:693-8. 2010
    ..To identify and compare clinical and neuroimaging predictors of primary lobar intracerebral hemorrhage (ICH) recurrence, assessing their relative contributions to recurrent ICH...
  44. ncbi Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease
    Dietmar Rudolf Thal
    Institute of Pathology, University of Ulm, Albert Einstein Allee 11, Ulm, Germany
    Acta Neuropathol 120:169-83. 2010
    The deposition of amyloid beta-protein (Abeta) in the vessel wall, i.e., cerebral amyloid angiopathy (CAA), is associated with Alzheimer's disease (AD)...
  45. ncbi Apolipoprotein E, smooth muscle cells and the pathogenesis of cerebral amyloid angiopathy: the potential role of impaired cerebrovascular A beta clearance
    R Prior
    Department of Neurology, University of Duesseldorf, Germany
    Ann N Y Acad Sci 903:180-6. 2000
    b>Cerebral amyloid angiopathy (CAA) is caused by the deposition of beta-amyloid (A beta) in Alzheimer disease brains. It also occurs isolated, representing a major cause for cerebral hemorrhage in the elderly...
  46. ncbi The contribution of cerebral vascular semicarbazide-sensitive amine oxidase to cerebral amyloid angiopathy in Alzheimer's disease
    Z J Jiang
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, SK, Canada
    Neuropathol Appl Neurobiol 34:194-204. 2008
    ..the hallmark of Alzheimer's disease (AD), are closely associated with cerebral blood vessels, that is, cerebral amyloid angiopathy (CAA). In the present study, we examined whether SSAO-mediated deamination contributes to CAA in AD...
  47. ncbi No mutations in cystatin C gene in cerebral amyloid angiopathy with cystatin C deposition
    A Nagai
    Department of Internal Medicine III, Shimane Medical University, Izumo, Japan
    Mol Chem Neuropathol 33:63-78. 1998
    To investigate the relationship between cerebral amyloid angiopathy (CAA) and cystatin C, we studied five CAA patients on whose cerebral blood vessels colocalization of cystatin C and beta-protein was recognized immunohistochemically...
  48. ncbi Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications
    Hans Christian Koennecke
    Department of Neurology, Evangelisches Krankenhaus Konigin Elisabeth Herzberge, Berlin, Germany
    Neurology 66:165-71. 2006
    ..To assess the potential role of cerebral microbleeds (CMB) in intracerebral hemorrhage (ICH), as indicators of cerebral small-vessel disease, and their possible implications for antithrombotic treatment...
  49. pmc ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides
    Huaqi Xiong
    Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    J Neurosci 29:5463-75. 2009
    ..Abeta deposition in cerebrovessels occurs in many AD patients and results in cerebral amyloid angiopathy (AD/CAA)...
  50. ncbi Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study
    M W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Neurology 70:1208-14. 2008
    ..of microbleeds differs according to their location in the brain, with lobar microbleeds being caused by cerebral amyloid angiopathy and deep or infratentorial microbleeds resulting from hypertension and atherosclerosis...
  51. pmc Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice
    Iliya Lefterov
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 285:36945-57. 2010
    ..To examine the effect of Apoa-I deletion on cerebral amyloid angiopathy, we measured insoluble Aβ isolated from cerebral blood vessels...
  52. ncbi Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging
    Claudia M Prada
    Department of Neurology Alzheimer Research Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 27:1973-80. 2007
    b>Cerebral amyloid angiopathy (CAA) is the accumulation of amyloid-beta peptide (Abeta) in the vessel wall of arteries in the brain...
  53. ncbi Reversible leukoencephalopathy associated with cerebral amyloid angiopathy
    U Oh
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Neurology 62:494-7. 2004
    The authors describe three patients with reversible leukoencephalopathy associated with cerebral amyloid angiopathy (CAA). Rapid progression of neurologic symptoms was followed by dramatic clinical and radiographic improvement...
  54. ncbi Cerebral amyloid angiopathy: CT and MR imaging findings
    Christine P Chao
    Department of Radiology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Radiographics 26:1517-31. 2006
    b>Cerebral amyloid angiopathy (CAA) is an important but underrecognized cause of cerebrovascular disorders that predominantly affect elderly patients...
  55. ncbi Microbleeds in Alzheimer disease are more related to cerebral amyloid angiopathy than cerebrovascular disease
    Yuriko Nakata-Kudo
    Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Dement Geriatr Cogn Disord 22:8-14. 2006
    b>Cerebral amyloid angiopathy (CAA) is one of the cardinal pathological features in the vascular components of Alzheimer's disease (AD)...
  56. pmc Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review
    Hannah A D Keage
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    BMC Neurol 9:3. 2009
    Deposition of amyloid-beta (Abeta) in vessel walls of the brain as cerebral amyloid angiopathy (CAA) could be a major factor in the pathogenesis of dementia...
  57. ncbi Small heat shock proteins induce a cerebral inflammatory reaction
    Ilona B Bruinsma
    Departments of Neurology and Alzheimer Centre, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurosci 31:11992-2000. 2011
    More than 80% of Alzheimer's disease (AD) patients have some degree of cerebral amyloid angiopathy (CAA). In addition to arteries and veins, capillaries can also be affected...
  58. ncbi Declining expression of neprilysin in Alzheimer disease vasculature: possible involvement in cerebral amyloid angiopathy
    Mélanie Carpentier
    Departement de Biochimie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    J Neuropathol Exp Neurol 61:849-56. 2002
    ..In sections from AD patients we observed a clear inverse relationship between neprilysin and A beta peptide levels in the vasculature, implicating neprilysin in cerebral amyloid angiopathy.
  59. ncbi Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study
    Melita Salkovic-Petrisic
    Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia
    J Neural Transm 118:765-72. 2011
    b>Cerebral amyloid angiopathy is manifested as accumulation of amyloid β (Aβ) peptide in the wall of meningeal and cerebral arteries, arterioles and capillaries and is frequently found postmortem in sporadic Alzheimer's disease (sAD) ..
  60. pmc Cerebral amyloid angiopathy in the elderly
    Anand Viswanathan
    Department of Neurology and Clinical Trials Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 70:871-80. 2011
    b>Cerebral amyloid angiopathy (CAA) results from deposition of β-amyloid in the media and adventitia of small arteries and capillaries of the leptomeninges and cerebral cortex and is a major cause of lobar intracerebral hemorrhage and ..
  61. ncbi Colocalization of different types of amyloid in the walls of cerebral blood vessels of patients suffering from cerebral amyloid angiopathy and spontaneous intracranial hemorrhage: a report of 5 cases
    R A W Galuske
    Institute of Neurology of the University Edinger Institute, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Clin Neuropathol 23:113-9. 2004
    Four cases of spontaneous intracranial hemorrhage (ICH) are described in which the diagnosis of a cerebral amyloid angiopathy (CAA) was made in the biopsy specimens...
  62. ncbi Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis
    Rudy J Castellani
    Division of Neuropathology, Michigan State University, B218 Clinical Center, 138 Service Road, East Lansing, MI 48824 1313, USA
    Neurobiol Aging 25:599-602; discussion 603-4. 2004
    Amyloid deposition within cerebral vessels, or cerebral amyloid angiopathy (CAA), is common in advanced age and even more common in Alzheimer's disease...
  63. pmc Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy
    W T Kimberly
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neurology 72:1230-5. 2009
    Neuropathologic studies suggest an association between cerebral amyloid angiopathy (CAA) and small ischemic infarctions as well as hemorrhages...
  64. pmc Genetic variation at CR1 increases risk of cerebral amyloid angiopathy
    A Biffi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Neurology 78:334-41. 2012
    ..Given the biologic overlap between AD and cerebral amyloid angiopathy (CAA), a leading cause of intracerebral hemorrhage (ICH) in elderly individuals, we investigated ..
  65. pmc Cerebral amyloid angiopathy pathology and cognitive domains in older persons
    Zoe Arvanitakis
    Rush Alzheimer s Disease Center, Chicago, IL, USA
    Ann Neurol 69:320-7. 2011
    To examine the relation of cerebral amyloid angiopathy (CAA) to cognitive domains in older community-dwelling persons with and without dementia.
  66. doi Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease
    Howard H Feldman
    Stroke 39:2894-7. 2008
    ..In cerebral amyloid angiopathy (CAA), there is amyloid deposition in meningeal and meningo-cortical arteries and capillaries, ..
  67. ncbi C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type
    M H Baumann
    Department of Pathology, New York University Medical Center, New York 10016, USA
    Biochem Biophys Res Commun 219:238-42. 1996
    ..These findings suggest that the C-terminal fragments of both alpha- and beta-tubulin are closely associated to the amyloid deposits of familial amyloidosis, British type...
  68. pmc Steroid responsive encephalopathy in cerebral amyloid angiopathy: a case report and review of evidence for immunosuppressive treatment
    Raoul P Kloppenborg
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    J Neuroinflammation 7:18. 2010
    b>Cerebral amyloid angiopathy (CAA) is a common but often asymptomatic disease, characterized by deposition of amyloid in cerebral blood vessels...
  69. ncbi Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage
    Mark O McCarron
    Department of Neurology, Altnagelvin Hospital, Londonderry, BT47 6SB, UK
    Lancet Neurol 3:484-92. 2004
    ..There is increasing evidence that cerebral amyloid angiopathy (CAA), which itself can cause haemorrhage (CAAH), may be a risk factor for thrombolysis-related ..
  70. pmc The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease
    Silke Vogelgesang
    Department of Neuropathology, University of Greifswald, Germany
    Curr Alzheimer Res 1:121-5. 2004
    ..As we were interested in the early pathogenesis of Abeta deposition, we studied the correlation between cerebral amyloid angiopathy (CAA) and P-gp expression in brain tissue samples from 243 non-demented elderly cases (aged 50 to 91 ..
  71. pmc Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy
    Vitaly Vasilevko
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA
    Ann N Y Acad Sci 1207:58-70. 2010
    ..dysfunction contributes to ischemic stroke, intracerebral hemorrhages (ICHs), microbleeds, cerebral amyloid angiopathy (CAA), and cognitive decline...
  72. ncbi Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy
    T J Grabowski
    Department of Neurology and Radiology, College of Medicine, University of Iowa, Iowa City, USA
    Ann Neurol 49:697-705. 2001
    ..Neuropathological examination of the proband revealed severe cerebral amyloid angiopathy, widespread neurofibrillary tangles, and unusually extensive distribution of Abeta40 in plaques...
  73. ncbi Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement
    James A R Nicoll
    Clinical Neurosciences, University of Southampton, Southampton General Hospital, Mailpoint 813, Southampton, SO 16 6YD, UK
    Neurobiol Aging 25:589-97; discussion 603-4. 2004
    For the purposes of this debate here we argue the case that cerebral amyloid angiopathy (CAA) has a direct role in the pathogenesis of Alzheimer's disease (AD)...
  74. ncbi Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease
    Dietmar Rudolf Thal
    Institute of Pathology Laboratory of Neuropathology University of Ulm, Ulm, Germany
    J Cell Mol Med 12:1848-62. 2008
    ..Abeta-deposits show the morphology of senile plaques and cerebral amyloid angiopathy (CAA). Senile plaques and vascular Abeta-deposits occur first in neocorti-cal areas...
  75. ncbi Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study
    L A Pfeifer
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging NIH, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
    Neurology 58:1629-34. 2002
    To investigate the relationship between cerebral amyloid angiopathy (CAA), dementia, and cognitive function in an autopsy sample of 211 Japanese-American men from the population-based Honolulu-Asia Aging Study.
  76. pmc Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice
    Deepak R Thakker
    Medtronic, Inc, Minneapolis, MN 55432, USA
    Proc Natl Acad Sci U S A 106:4501-6. 2009
    ..e., cerebral amyloid angiopathy (CAA)] and a heightened risk of micro-hemorrhages...
  77. ncbi Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy
    D T Winkler
    Department of Neuropathology, Institute of Pathology, University of Basel, CH 4003 Basel, Switzerland
    J Neurosci 21:1619-27. 2001
    A high risk factor for spontaneous and often fatal lobar hemorrhage is cerebral amyloid angiopathy (CAA)...
  78. pmc Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging
    Christopher M Holland
    Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Stroke 39:1127-33. 2008
    ..We sought to determine whether the spatial distribution of WMHs discriminates between different disease groups and healthy aging individuals and whether these distributions are related to local cerebral perfusion patterns...
  79. pmc Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy
    R Christie
    Department of Neurology, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Pathol 158:1065-71. 2001
    The deposition of amyloid Abeta peptide in the wall of cerebral vessels (cerebral amyloid angiopathy), can lead to weakness and rupture of the vessel wall, resulting in hemorrhagic stroke...
  80. ncbi Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy
    James Scott Miners
    Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol, United Kingdom
    J Neuropathol Exp Neurol 65:1012-21. 2006
    ..In Alzheimer disease (AD), downregulation of NEP has been suggested to contribute to the development of cerebral amyloid angiopathy (CAA). We examined the relationship among NEP, CAA, and APOE status in AD and elderly control cases...
  81. ncbi Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease
    Oda Christina Suter
    University Institute of Pathology, Division of Neuropathology, University Medical School, University of Lausanne, Lausanne, Switzerland
    Stroke 33:1986-92. 2002
    ..Cerebral hypoperfusion is associated with Alzheimer disease (AD), but information regarding the occurrence of watershed cortical infarcts in AD is lacking...
  82. ncbi Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy
    James R Bading
    Department of Radiology, USC School of Medicine, Los Angeles, CA 90033, USA
    J Drug Target 10:359-68. 2002
    ..Thus, vascular clearance plays an important role in reducing Abeta levels in the squirrel monkey brain and impaired Abeta40 elimination across the BBB may contribute to the development of CAA...
  83. pmc Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study
    Fiona E Matthews
    Medical Research Council MRC Biostatistics, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 6:e1000180. 2009
    ..We report the attributable risks (ARs) for dementia at death for common age-related degenerative and vascular pathologies, and other factors, in the MRC Cognitive Function and Ageing Study (MRC CFAS)...
  84. ncbi The cerebral beta-amyloid angiopathies: hereditary and sporadic
    Sandy X Zhang-Nunes
    Neurology Clinical Trials Unit and MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    Brain Pathol 16:30-9. 2006
    We review the clinical, radiologic, and neuropathologic features of the hereditary and sporadic forms of cerebral amyloid angiopathy (CAA) associated with vascular deposition of the beta-amyloid peptide...
  85. ncbi Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23
    Kazuma Murakami
    Laboratory of Organic Chemistry in Life Science, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 294:5-10. 2002
    b>Cerebral amyloid angiopathy (CAA) due to amyloid beta (A beta) deposition is a key pathological feature of Alzheimer's disease (AD), especially in some form of familial Alzheimer's disease (FAD) including hereditary cerebral hemorrhage ..
  86. pmc Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition
    Byung Hee Han
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 28:13542-50. 2008
    ..expressing mutant amyloid precursor protein (APP) and having elevated levels of soluble Abeta but no cerebral amyloid angiopathy (CAA)...
  87. ncbi Characteristics of dyshoric capillary cerebral amyloid angiopathy
    Edo Richard
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 69:1158-67. 2010
    b>Cerebral amyloid angiopathy (CAA) affects brain parenchymal and leptomeningeal arteries and arterioles but sometimes involves capillaries (capCAA) with spread of the amyloid into the surrounding neuropil, that is, dyshoric changes...
  88. ncbi The genetic architecture of intracerebral hemorrhage
    Natalia S Rost
    Department of Neurology, and Hemorrhagic Stroke Research Program, Massachusetts General Hospital, 185 Cambridge Street, Boston MA 02114, USA
    Stroke 39:2166-73. 2008
    ..This review focuses on evidence for a genetic contribution to ICH, delineates approaches to genetic studies of ICH, and explores foundations for their future applications...
  89. ncbi Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study
    J Rosand
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neurology 55:947-51. 2000
    ..The pathogenesis of this often-fatal complication remains obscure. Cerebral amyloid angiopathy (CAA) is a major cause of spontaneous lobar hemorrhage in the elderly and is associated with specific ..
  90. pmc Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy
    Marcel M Verbeek
    Department of Neurology, Radboud University Nijmegen Medical Center, Donders Center for Brain, Cognition and Behavior, Nijmegen, The Netherlands
    Ann Neurol 66:245-9. 2009
    b>Cerebral amyloid angiopathy is caused by deposition of the amyloid beta protein in the cerebral vasculature...
  91. ncbi Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
    L Hendriks
    Department of Biochemistry, Born Bunge Foundation, University of Antwerp UIA, Belgium
    Nat Genet 1:218-21. 1992
    ..the APP gene which co-segregates in one family with presenile dementia and cerebral haemorrhage due to cerebral amyloid angiopathy. The mutation results in the substitution of alanine into glycine at codon 692...
  92. ncbi Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
    D Boche
    Division of Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Brain 131:3299-310. 2008
    ..peptide (Abeta) in the brain both in the form of plaques in the cerebral cortex and in blood vessel as cerebral amyloid angiopathy (CAA)...
  93. ncbi Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy
    Johannes Attems
    Pathological Institute, Otto Wagner Hospital, Baumgartner Hohe 1, 1140, Vienna, Austria
    Acta Neuropathol 110:222-31. 2005
    b>Cerebral amyloid angiopathy (CAA) is defined by beta-amyloid peptide (Abeta) depositions in cerebral vessels and is associated with Alzheimer's disease (AD)...
  94. ncbi Primary central nervous system vasculitis: comparison of patients with and without cerebral amyloid angiopathy
    C Salvarani
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Rheumatology (Oxford) 47:1671-7. 2008
    To describe the clinical features and outcomes of patients with primary central nervous system vasculitis (PCNSV) and cerebral amyloid angiopathy (CAA) from a large cohort of consecutive patients with PCNSV treated at a single institution.
  95. ncbi Course of cerebral amyloid angiopathy-related inflammation
    C Kinnecom
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurology 68:1411-6. 2007
    A subset of patients with cerebral amyloid angiopathy (CAA) present with cognitive symptoms, seizures, headaches, T2-hyperintense MRI lesions, and neuropathologic evidence of CAA-associated vascular inflammation.
  96. ncbi Cerebral amyloid angiopathy: a common cause of cerebral hemorrhage
    A Pezzini
    Department of Medical and Surgical Sciences, Neurology Clinic, University of Brescia, Brescia, Italy
    Curr Med Chem 16:2498-513. 2009
    ..b>Cerebral amyloid angiopathy (CAA) defines a clinicopathological phenomenon characterized by amyloid deposition in the walls of ..
  97. ncbi Beta-amyloid deposition in brains of subjects with diabetes
    I Alafuzoff
    Unit of Neurology, Department of Clinical Medicine, Kuopio University and Kuopio University Hospital, Kuopio, Finland
    Neuropathol Appl Neurobiol 35:60-8. 2009
    ..The objective of this study was to test the hypothesis that hyperinsulinaemia can elevate Abeta levels and thus contribute to AD pathology in humans...
  98. ncbi Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy
    Jin Moo Lee
    Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8111, St Louis, MO, USA
    Ann Neurol 54:379-82. 2003
    ..the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage...
  99. ncbi Cerebral amyloid angiopathy and lobar intracerebral hemorrhage
    Eric E Smith
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Neurol 63:148-51. 2006
  100. ncbi A physiologic biomarker for cerebral amyloid angiopathy
    M Edip Gurol
    From the Department of Neurology, Massachusetts General Hospital, Boston
    Neurology 81:1650-1. 2013
    b>Cerebral amyloid angiopathy (CAA), a common small-vessel disease of older adults characterized by accumulation of amyloid-β in leptomeningeal and cortical blood vessels, is a well-established cause of intracerebral hemorrhage...
  101. pmc Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy
    Parham Moftakhar
    Department of Radiology and Biomedical Imaging, UCSF Medical Center, San Francisco, CA, USA
    J Neuropathol Exp Neurol 69:1201-9. 2010
    ..in the edema formation and alterations in microvascular function observed in Alzheimer disease (AD) and cerebral amyloid angiopathy (CAA)...

Research Grants62

  1. THE ROLE OF A-BETA SPECIES IN VASCULAR SMOOTH MUSCLE CELL AND CEREBRAL ARTERIOLE
    Gregory J Zipfel; Fiscal Year: 2013
    ..AD patients develop A[unreadable] deposits not only in brain but also in vessels - a condition known as cerebral amyloid angiopathy (CAA)...
  2. Effect of White Matter Disease on Gait and Balance in Cerebral Amyloid Angiopathy
    Anand Viswanathan; Fiscal Year: 2013
    b>Cerebral amyloid angiopathy (CAA) leads to cerebrovascular deposition of ss-amyloid resulting in vessel fragility and intracerebral hemorrhage (ICH)...
  3. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2013
    ..and upregulation of salutary humoral responses, A[unreadable] levels/[unreadable]- amyloid deposits and cerebral amyloid angiopathy (CAA;an inflammatory response to vascular amyloid deposits) are reduced by HUCBC infusion in vivo, with ..
  4. iPSC from British and Danish dementias: new discovery tools for brain amyloidoses
    JORGE A GHISO; Fiscal Year: 2013
    ..of Alzheimer's disease (AD) including parenchymal amyloid and pre- amyloid lesions, widespread cerebral amyloid angiopathy and neurofibrillary tangles morphologically and immunochemically indistinguishable from those in AD...
  5. Molecular Mechanisms of Prion and Amyloid Propagation
    Christopher P Jaroniec; Fiscal Year: 2013
    ..This C-truncated PrP mutant is associated with hereditary cerebral amyloid angiopathy in humans and exhibits in vitro some of the most fundamental aspects of PrP propagation including the ..
  6. HUCBC modulation of Alzheimer's-like pathology and behavioral changes
    Jun Tan; Fiscal Year: 2012
    ..believed that upregulated CD40 and CD40L expression in collaboration with cerebral Ab deposits promote cerebral amyloid angiopathy (CAA). Our study found a marked reduction of CAA and microhemorrhage...
  7. Dietary and Visceral Fat Regulate Vascular Amyloid Pathogenesis
    JEFFREY NEIL KELLER; Fiscal Year: 2012
    ..on the modulation of Abeta pathology, and the consequences of Abeta pathology, using a mouse model of cerebral amyloid angiopathy (CAA)...
  8. Testing of Innate Immunity Stimulation via TLR9 on CAA using Non-human Primates.
    Henrieta Scholtzova; Fiscal Year: 2013
    ..This is an important issue, since cerebral amyloid angiopathy (CAA) is a common feature of patients with AD and cognitively normal elderly individuals...
  9. Effect of apoE on CNS neurons: Role of LRP
    David M Holtzman; Fiscal Year: 2013
    ..by which A[3 converts from soluble to fibrillar forms (amyloid) with neuritic plaque formation and cerebral amyloid angiopathy (CAA)...
  10. Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study
    Jose Rafael Romero; Fiscal Year: 2013
    ..CMB are more frequent in advanced age, and are attributed to hypertensive vasculopathy or cerebral amyloid angiopathy. They have been related to an increased risk of stroke (especially brain hemorrhage) cognitive ..
  11. Biological Spatial Resolution Limits in fMRI
    JONATHAN RIZZO POLIMENI; Fiscal Year: 2013
    ..visual deficits or amblyopia, measuring the impact of localized hyperemia in patients with occipital cerebral amyloid angiopathy, designing cortical prostheses, and will enable future studies into the fine organization of the ..
  12. Spatial and temporal progression of amyloid angiopathy
    Matthew P Frosch; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cerebral amyloid angiopathy (CAA), the age-related deposition of cerebrovascular ft-amyloid (AH), is a common cause of hemorrhagic stroke, an accompanying pathology in most cases of Alzheimer disease ..
  13. CELL-CELL INTERACTION AND HYPOXIC BRAIN INJURY
    Jin Moo Lee; Fiscal Year: 2010
    ..David Holtzman and Hans Dietrich will use in vivo and in situ approaches to examine effects of cerebral amyloid angiopathy on arteriolar function, an emerging cause of ischemic and hemorrhagic stroke in the elderly...
  14. Early Detection of Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deposition of ss-amyloid (Ass) in the cerebral vessels (cerebral amyloid angiopathy or CAA) is a major cause of hemorrhagic stroke, a contributor to vascular cognitive impairment, and a complicating ..
  15. Detection and Clearance of AD Lesions
    Thomas M Wisniewski; Fiscal Year: 2013
    ..The extracellular accumulations of amyloid [unreadable] (A[unreadable]) peptides as plaques and cerebral amyloid angiopathy (CAA), as well as intracellular neurofibrillary tangles (NFTs) are pathological hallmarks of Alzheimer&..
  16. HEMORHEOLOGICAL FACTORS IN CEREBRAL ISCHEMIA
    Mark J Fisher; Fiscal Year: 2013
    ..exacerbation, mitigation, and mechanisms of brain microvascular hemorrhage in vivo, using models of cerebral amyloid angiopathy and aging...
  17. Pathological Influence of Vasculotropic Mutant Amyloid-Beta
    William E Van Nostrand; Fiscal Year: 2011
    ..Cerebrovascular accumulation of the amyloid [unreadable]-protein (A[unreadable]), a condition known as cerebral amyloid angiopathy (CAA), is a common pathological feature of patients with Alzheimer's disease (AD) and several ..
  18. Targeting the apoE/ABeta Interaction as a Novel AD Therapy
    MARTIN JOSEPH SADOWSKI; Fiscal Year: 2013
    ..and subsequently into deposits in the brain's parenchyma and in walls of vessels producing cerebral amyloid angiopathy (CAA)...
  19. White matter hyperintensities in Aging and Dementia
    Adam M Brickman; Fiscal Year: 2013
    ..3. To examine the association of WMH distribution and lobar microbleeds, a putative marker of cerebral amyloid angiopathy, among patients with AD and controls...
  20. Vascular Dysfunction in Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2013
    PROJECT SUMMARY/ABSTRACT A strong body of evidence implicates cerebrovascular ss-amyloid (cerebral amyloid angiopathy or CAA) as a relatively common independent contributor to cognitive impairment in the elderly, most likely by effects ..
  21. Clinical, Radiographic, and Genetic Associations in Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): There is no known treatment for cerebral amyloid angiopathy (CAA), an important cause of hemorrhagic stroke and increasingly recognized contributor to vascular cognitive impairment and neurological ..
  22. Brain and Spinal Cord Microvascular Pathology in Late-Life Motor Impairment
    Aron S Buchman; Fiscal Year: 2013
    ..investigate specific microvascular pathologies including, arteriolosclerosis, microscopic infarcts and cerebral amyloid angiopathy. These pathologies are not visible via brain imaging and can only be directly studied using ..
  23. Cerebral Amyloid Angiopathy and Related Cerebral Microvasculopathies
    Harry Vinters; Fiscal Year: 2009
    This application seeks support for a conference entitled Cerebral Amyloid Angiopathy and Related Cerebral Microvasculopathies to be held November 12-14, 2009, at the Ronald Reagan UCLA Medical Center and David Geffen School of Medicine ..
  24. Cerebral Amyloid Angiopathy, Vascular Dysfunction & Ischemic Brain Injury
    Gregory J Zipfel; Fiscal Year: 2010
    ..the mechanisms underlying ischemic brain injury and intracerebral hemorrhage, with an emphasis on cerebral amyloid angiopathy (CM). The proposed period of mentored scientific training in the laboratory of Dr...
  25. Small Arteries as a Therapeutic Target in AD
    Nienwen Chow; Fiscal Year: 2004
    ..These arteries are often the site of amyloid deposition and pathology associated with cerebral amyloid angiopathy (CAA), one of the hallmarks of AD...
  26. CHARACTERIZATION OF CEREBRAL AMYLOID ANGIOPATHIC PEPTIDE
    Harry Vinters; Fiscal Year: 1992
    ..of the project are to examine the biochemical nature, immunocytochemistry, and pathogenesis of cerebral amyloid angiopathy (CAA), a microvascular change in human brain that correlates with non-traumatic intracerebral ..
  27. Novel Intervention for Amyloid-Induced Neuroinflammation
    MICHAEL VITEK; Fiscal Year: 2007
    ..Fibrillar A[unreadable] deposition in the cerebral vasculature, a condition known as cerebral amyloid angiopathy (CAA), is also commonly found in AD...
  28. 7th International Cerebral Vascular Biology Conference
    Adam Chodobski; Fiscal Year: 2007
    ..Many neurological disorders and lesions are associated with prominent cerebrovascular pathology (e.g., cerebral amyloid angiopathy in Alzheimer's disease, atherosclerosis in stroke, etc.) and/or increased BBB permeability...
  29. ROLE OF TGF B1 IN CEREBROVASCULAR AMYLOIDOSIS
    Tony Wyss Coray; Fiscal Year: 2002
    DESCRIPTION (From Abstract): Cerebrovascular deposition of amyloid, or cerebral amyloid angiopathy (CAA), is a prime cause of normotensive intracerebral hemorrhages in the elderly...
  30. Dysregulation of the neurovascular unit in Alzheimer's Disease.
    Donna Wilcock; Fiscal Year: 2009
    ..There is also a vascular component consisting of amyloid deposition in the vasculature termed cerebral amyloid angiopathy (CAA). Microhemorrhages are frequently observed in association with CAA...
  31. Formation and Function of Prefibrillar Amyloid Beta Assemblies
    David Teplow; Fiscal Year: 2007
    ..Abeta) assembly is a seminal neuropathogenetic process in Alzheimer's disease (AD) and in cerebral amyloid angiopathy (CAA). If so, controlling Abeta assembly could be of therapeutic value...
  32. Novel A-beta mutation associated with familial CAA
    G Rebeck; Fiscal Year: 2001
    ..We examined a family from Iowa with a history of cerebral amyloid angiopathy, a disease of amyloid deposition in the cerebrovasculature which leads to hemorrhagic strokes...
  33. BRAIN MICROVASCULATURE IN AGING AND DEMENTIA
    Marcus Raichle; Fiscal Year: 1993
    ..Three general abnormalities have been described. First, cerebral amyloid angiopathy (CAA), characterized by the presence of amyloid within brain capillary and arteriolar walls, is a ..
  34. RENOVATIONS FOR CAGEWASH SUPPORT SERVICE
    Thomas Zimmerman; Fiscal Year: 2005
    ..and viral receptor regulation; targeted gene therapy; infectious disease pathogenesis; oncology; cerebral amyloid angiopathy; vaccine development; and membrane transport, currently house animals within the Health Sciences Center ..
  35. TRANSGENIC MODELS OF ALZHEIMERS DISEASE
    Michael Irizarry; Fiscal Year: 2001
    ..of APP over-expression in vascular smooth muscle by producing and evaluating a new transgenic model of cerebral amyloid angiopathy. The candidate is a board certified neurologist who has completed two productive years of fellowship ..
  36. EQUIPMENT FOR MAXIMUM ISOLATION OVERFLOW HOUSING
    BEVERLY GNADT; Fiscal Year: 2003
    ..and viral receptor regulation; targeted gene therapy; infectious disease pathogenesis; oncology; cerebral amyloid angiopathy; vaccine development; and membrane transport, currently house animals in this overflow space...
  37. RENOVATIONS FOR AUTOCLAVE SUPPORT SERVICE
    Norman Edelman; Fiscal Year: 2004
    ..and viral receptor regulation; targeted gene therapy; infectious disease pathogenesis; oncology; cerebral amyloid angiopathy; vaccine development; and membrane transport, currently house maximum isolation rodents who require ..
  38. MOLECULAR RISK FACTORS FOR CEREBRAL AMYLOID ANGIOPATHY
    Steven Greenberg; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the application) Cerebral amyloid angiopathy (CAA) is a major cause of primary intracerebral hemorrhage in the elderly and a disease of growing importance in the aging population...
  39. VASCULAR CHANGES IN AMYLOID ANGIOPATHY TRANSGENIC MODEL
    Steven Greenberg; Fiscal Year: 1999
    We propose to create an animal model of cerebral amyloid angiopathy (CAA), a growing and untreatable cause of stroke...
  40. 500 MHz Solid-State NMR Spectrometer
    Steven Smith; Fiscal Year: 2009
    ..the structure, formation and inhibition of amyloid fibrils involved in Alzheimer's disease and cerebral amyloid angiopathy (CAA)...
  41. MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORS
    Raj Kalaria; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  42. Genetic Risks for Medication-Related Hemorrhagic Stroke
    Steven Greenberg; Fiscal Year: 2007
    ..This proposal is thus likely to form the foundation of a powerful, open-ended search for a panel of genetic tests to determine an individual's risk for Warfarin-related ICH. ..
  43. NC-758 for Prevention of Recurrent Cerebral Hemorrhage
    Steven Greenberg; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): There is no known therapy for Cerebral Amyloid Angiopathy (CAA), an important cause of hemorrhagic stroke and other clinical syndromes in the elderly...
  44. BETA AND ITS PRECURSOR INFLUENCE HEMOSTATIC ENZYMES
    William Van Nostrand; Fiscal Year: 2001
    ....
  45. AbetaPP and Cerebral Vasculopathy
    William Van Nostrand; Fiscal Year: 2006
    ..by applicant): Cerebrovascular deposition of the amyloid beta-protein (AB), a condition known as cerebral amyloid angiopathy (CAA), is a common pathological feature of patients with Alzheimer's disease (AD) and related ..
  46. Transgenic Model for Cerebral Amyloid Angiopathy
    William Van Nostrand; Fiscal Year: 2006
    ..Cerebrovascular deposition of the amyloid [unreadable]-protein (A[unreadable]), a condition known as cerebral amyloid angiopathy (CAA), is a common pathological feature of patients with Alzheimer's disease (AD) and several ..
  47. Amyloid Beta Protein Precursor Influences Cerebral Thrombosis
    William E Van Nostrand; Fiscal Year: 2010
    ..This may lead to new avenues for developing strategies to regulate cerebral thrombosis and limit damage to the brain as a consequence of hemorrhagic and ischemic stroke. ..
  48. Cerebral Microvascular Amyloid: Neuroinflammation and Cognitive Deficits
    William E Van Nostrand; Fiscal Year: 2010
    ..Fibrillar A[unreadable] deposition in the cerebral vasculature, a condition known as cerebral amyloid angiopathy (CAA), is also commonly found in Alzheimer's disease...
  49. ALZHEIMER'S DISEASE AND CEREBRAL AMYLOID ANGIOPATHY
    Helena Chui; Fiscal Year: 1993
  50. Leukoaraiosis in Cerebral Amyloid Angiopathy
    Eric Smith; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Sporadic cerebral amyloid angiopathy (CAA) is a disorder of the elderly in which A beta deposition in the cortical and leptomeningeal arteries leads to vessel fragility and rupture...
  51. APOE EFFECT ON CNS NEURONS--ROLE OF LRP
    David Holtzman; Fiscal Year: 2003
    ..These studies with physiological preparations of apoE as well as both in vivo and in vitro models should provide new insights into mechanisms underlying the link between apoE, LRP, ABeta, and Alzheimer's disease. ..
  52. CNS/plasma ABeta clearance of anti-ABeta antibody
    David Holtzman; Fiscal Year: 2003
    ..This will determine how anti-Abeta antibodies influence CNS/plasma Abeta transport exchanges. ..
  53. BETAAPP MODULATION BY THE ADAPTER PROTEINS FE65 AND X11
    Efrat Levy; Fiscal Year: 2003
    ..Manipulating the interaction of Beta-APP with an effector protein, such as X11 or Fe65, may provide a novel approach for the pharmacological modulation of Beta-APP processing in Alzheimer's disease. ..
  54. AMYLOID INDUCED CEREBROENDOTHELIAL DEGENERATION
    Jin Moo Lee; Fiscal Year: 2004
    ..This effect of A,8 may contribute to the age-dependent development of cerebral amyloid angiopathy (CAA). The molecular mechanisms of AB cytotoxicity in CECs have not been fully elucidated...
  55. THE ROLE OF ZINC IN FOCAL ISCHEMIC BRAIN INJURY
    Jin Moo Lee; Fiscal Year: 2004
    ..been pursuing this new direction, studying the pathogenesis of spontaneous intracerebral hemorrhage in cerebral amyloid angiopathy (CAA)...
  56. Animal models for cerebral amyloid angiopathy
    Efrat Levy; Fiscal Year: 2006
    ..are several indications that cystatin C also has a pathogenic role in Alzheimer's disease (AD), in cerebral amyloid angiopathy and in cerebral hemorrhage...
  57. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2010
    ..If the hypothesis is true, potential targets for intervention to degrade plaques may be identified. ..
  58. Mechanisms of Amyloid Angiopathy-Related Hemorrhage
    Jin Moo Lee; Fiscal Year: 2009
    ..Angiopathy-Related Hemorrhage The deposition of amyloid-beta peptide (A-beta) in cerebral vessels (cerebral amyloid angiopathy, CAA) is a common finding in the elderly, and especially prominent in patients with Alzheimer's ..
  59. Survival and Comorbidities after Dementia
    Annette Fitzpatrick; Fiscal Year: 2003
    ..This application will support continued analyses of an important database designed to provide valuable research for the prevention and impact of dementia in this country. ..
  60. Predictors of Alzheimers Disease in Mild Cognitive Impairment
    Oscar Lopez; Fiscal Year: 2007
    ..g., structural and perfusion MRI, plasma beta-amyloid) and the factors that modify the risk to express the clinical syndrome takes on an added importance. [unreadable] [unreadable] [unreadable] [unreadable]..
  61. Role of ABeta-Degrading Proteases in Alzheimer's Disease
    Wesley Farris; Fiscal Year: 2007
    ..The candidate's career development plan, world-class training environment, and commitment from his Department will allow the realization of this goal. ..