acidosis

Summary

Summary: A pathologic condition resulting from accumulation of acid or depletion of the alkaline reserve (bicarbonate) content of the blood and body tissues, and characterized by an increase in hydrogen ion concentration (decrease in pH). (Dorland, 27th ed)

Top Publications

  1. ncbi Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
  2. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
  3. ncbi Effects of acute alkalosis and acidosis on performance: a meta-analysis
    Amelia J Carr
    Physiology, Australian Institute of Sport, Canberra, ACT, Australia
    Sports Med 41:801-14. 2011
  4. ncbi Acid-mediated tumor invasion: a multidisciplinary study
    Robert A Gatenby
    Departments of Radiology, Applied Mathematics, and Optical Sciences, University of Arizona, Tucson, Arizona 85718, USA
    Cancer Res 66:5216-23. 2006
  5. ncbi The pathophysiologic and prognostic significance of acidosis in severe adult malaria
    N P Day
    Wellcome Trust Clinical Research Centre, Ho Chi Minh City, Vietnam
    Crit Care Med 28:1833-40. 2000
  6. pmc The genomic analysis of lactic acidosis and acidosis response in human cancers
    Julia Ling Yu Chen
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
    PLoS Genet 4:e1000293. 2008
  7. ncbi Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Eur J Appl Physiol 108:495-503. 2010
  8. ncbi The effects of extracellular pH on immune function
    A Lardner
    Department of Biological Sciences, Dublin Institute of Technology, Ireland
    J Leukoc Biol 69:522-30. 2001
  9. pmc Seizure termination by acidosis depends on ASIC1a
    Adam E Ziemann
    Medical Scientist Training Program, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Neurosci 11:816-22. 2008
  10. pmc Matriptase activation, an early cellular response to acidosis
    I Chu Tseng
    From the Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, and
    J Biol Chem 285:3261-70. 2010

Detail Information

Publications347 found, 100 shown here

  1. ncbi Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    Zhi Gang Xiong
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Cell 118:687-98. 2004
    ..b>Acidosis is a common feature of ischemia and is assumed to play a critical role in brain injury; however, the mechanism(s) ..
  2. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
    ..However, upregulation of glycolysis leads to microenvironmental acidosis requiring evolution to phenotypes resistant to acid-induced cell toxicity...
  3. ncbi Effects of acute alkalosis and acidosis on performance: a meta-analysis
    Amelia J Carr
    Physiology, Australian Institute of Sport, Canberra, ACT, Australia
    Sports Med 41:801-14. 2011
    ..Although individual responses may vary, we recommend ingestion of 0.3-0.5 g/kg/BM sodium bicarbonate to improve mean power by 1.7% (±2.0%) in high-intensity races of short duration...
  4. ncbi Acid-mediated tumor invasion: a multidisciplinary study
    Robert A Gatenby
    Departments of Radiology, Applied Mathematics, and Optical Sciences, University of Arizona, Tucson, Arizona 85718, USA
    Cancer Res 66:5216-23. 2006
    ..The acid-mediated tumor invasion model provides a simple mechanism linking altered glucose metabolism with the ability of tumor cells to form invasive cancers...
  5. ncbi The pathophysiologic and prognostic significance of acidosis in severe adult malaria
    N P Day
    Wellcome Trust Clinical Research Centre, Ho Chi Minh City, Vietnam
    Crit Care Med 28:1833-40. 2000
    To investigate the pathophysiology and prognostic significance of acidosis in severe adult malaria.
  6. pmc The genomic analysis of lactic acidosis and acidosis response in human cancers
    Julia Ling Yu Chen
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
    PLoS Genet 4:e1000293. 2008
    ..Two important determinants in this environment are hypoxia and lactic acidosis. Although lactic acidosis has long been recognized as an important factor in cancer, relatively little is known ..
  7. ncbi Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Eur J Appl Physiol 108:495-503. 2010
    ..b>Acidosis has been hypothesised to influence oxygen uptake kinetics during high-intensity exercise...
  8. ncbi The effects of extracellular pH on immune function
    A Lardner
    Department of Biological Sciences, Dublin Institute of Technology, Ireland
    J Leukoc Biol 69:522-30. 2001
    ..Increasing recognition of the significance of extracellular pH in relation to immune function warrants further studies in this presently incomplete but rewarding field...
  9. pmc Seizure termination by acidosis depends on ASIC1a
    Adam E Ziemann
    Medical Scientist Training Program, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Neurosci 11:816-22. 2008
    ..Observations that seizures reduced brain pH and that acidosis inhibited seizures indicate that acidosis halts epileptic activity...
  10. pmc Matriptase activation, an early cellular response to acidosis
    I Chu Tseng
    From the Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, and
    J Biol Chem 285:3261-70. 2010
    Extracellular acidosis often rapidly causes intracellular acidification, alters ion channel activities, and activates G protein-coupled receptors...
  11. ncbi Subacute ruminal acidosis induces ruminal lipopolysaccharide endotoxin release and triggers an inflammatory response
    G N Gozho
    Department of Animal Science, University of Manitoba, Winnipeg, Canada R3T 2N2
    J Dairy Sci 88:1399-403. 2005
    Subacute ruminal acidosis (SARA) was induced in 3 rumen fistulated Jersey steers by offering them different combinations of wheat-barley pellets and chopped alfalfa hay...
  12. pmc Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway
    Aishe Chen
    Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
    PLoS ONE 6:e27586. 2011
    ..the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood...
  13. ncbi Rapid astrocyte death induced by transient hypoxia, acidosis, and extracellular ion shifts
    A Bondarenko
    Department of Neurosurgery, New York University School of Medicine, New York, New York 10016, USA
    Glia 34:134-42. 2001
    Death of astrocytes requires hours to days in injury models that use hypoxia, acidosis, or calcium paradox protocols...
  14. ncbi Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis
    Ricardo Villa-Bellosta
    Laboratory of Molecular Toxicology, Veterinary Faculty, University of Zaragoza, Calle Miguel Servet 177, 50013 Zaragoza, Spain
    Pflugers Arch 459:499-508. 2010
    ..5, compared to a 0.6% Pi diet. The increase was only 11% at pH 6.0. Metabolic acidosis increased the expression of NaPi-IIc and Pit-2 in animals adapted to a low Pi diet, and phosphaturia was only ..
  15. ncbi The monitoring, prevention and treatment of sub-acute ruminal acidosis (SARA): a review
    Jörg M D Enemark
    University of Copenhagen, Faculty of Life Sciences, Department of Large Animal Sciences, Medicine and Surgery, Hoejbakkegaard Alle 5, DK 6230 Taastru, Denmark
    Vet J 176:32-43. 2008
    Sub-acute ruminal acidosis (SARA) has become an increasing problem in well-managed, high yielding dairy herds and the monitoring of groups of cows for signs of the condition is now crucial...
  16. pmc Lactate versus non-lactate metabolic acidosis: a retrospective outcome evaluation of critically ill patients
    Kyle J Gunnerson
    Virginia Commonwealth University Reanimation Engineering Shock Center Laboratory, Department of Anesthesiology Critical Care, Medical College of Virginia Virginia Commonwealth University, 1200 East Broad Street, Richmond, VA 23298, USA
    Crit Care 10:R22. 2006
    ..Differences in outcome exist between respiratory and metabolic acidosis in similar pH ranges...
  17. pmc Rumen microbiome composition determined using two nutritional models of subacute ruminal acidosis
    Ehsan Khafipour
    Department of Animal Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    Appl Environ Microbiol 75:7115-24. 2009
    Subacute ruminal acidosis (SARA) is a metabolic disease in dairy cattle that occurs during early and mid-lactation and has traditionally been characterized by low rumen pH, but lactic acid does not accumulate as in acute lactic acid ..
  18. pmc Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death
    Thomas W Sherwood
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 29:14371-80. 2009
    Acid-sensing ion channel 1a (ASIC1a) promotes neuronal damage during pathological acidosis. ASIC1a undergoes a process called steady-state desensitization in which incremental pH reductions desensitize the channel and prevent activation ..
  19. pmc Determinants of blood pH in health and disease
    J A Kellum
    University of Pittsburgh Medical Center, Division of Critical Care, Pittsburgh, Pennsylvania 15213 2582, USA
    Crit Care 4:6-14. 2000
    ..All changes in blood pH, in health and in disease, occur through changes in these three variables. Clinical implications for these findings are also discussed...
  20. ncbi Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors
    S Phisitkul
    Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Kidney Int 73:192-9. 2008
    ..a progressive decline in the glomerular filtration rate (GFR) of remnant kidneys associated with metabolic acidosis and an endothelin-mediated increase in renal acidification...
  21. pmc Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis
    Mirjam Moviat
    Department of Intensive Care Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Crit Care 7:R41-5. 2003
    Metabolic acidosis is the most frequent acid-base disorder in the intensive care unit. The optimal analysis of the underlying mechanisms is unknown.
  22. ncbi Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway
    Robert S Haworth
    Centre for Cardiovascular Biology and Medicine, King s College London, The Rayne Institute, St Thomas Hospital, London SE1 7EH, United Kingdom
    J Biol Chem 278:31676-84. 2003
    Activity of the Na+/H+ exchanger (NHE) isoform 1 (NHE1) is increased by intracellular acidosis through the interaction of intracellular H+ with an allosteric modifier site in the transport domain...
  23. ncbi Clinical utility of standard base excess in the diagnosis and interpretation of metabolic acidosis in critically ill patients
    M Park
    Departamento de Emergencia, Unidade de Terapia Intensiva, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 41:241-9. 2008
    ..aims of this study were to determine whether standard base excess (SBE) is a useful diagnostic tool for metabolic acidosis, whether metabolic acidosis is clinically relevant in daily evaluation of critically ill patients, and to ..
  24. ncbi The bacterial community of the horse gastrointestinal tract and its relation to fermentative acidosis, laminitis, colic, and stomach ulcers
    Rafat A M Al Jassim
    School of Animal Studies, The Faculty of Natural Resources, Agricultural and Veterinary Science, The University of Queensland, Gatton Campus, Queensland 4343, Australia
    Vet Clin North Am Equine Pract 25:199-215. 2009
    ....
  25. ncbi Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment
    Jeffrey A Kraut
    Division of Nephrology, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Am J Kidney Dis 45:978-93. 2005
    Metabolic acidosis is noted in the majority of patients with chronic kidney disease (CKD) when glomerular filtration rate (GFR) decreases to less than 20% to 25% of normal, although as many as 20% of individuals can have acid-base ..
  26. ncbi Inducing subacute ruminal acidosis in lactating dairy cows
    K M Krause
    School of Veterinary Medicine, University of Wisconsin Madison, Madison 53706, USA
    J Dairy Sci 88:3633-9. 2005
    Data from experiments in which subacute ruminal acidosis (SARA) was induced in lactating dairy cows (days in milk = 154 +/- 118) were evaluated to investigate the effectiveness of the induction protocol and its effect on production ..
  27. pmc Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death
    Thomas W Sherwood
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 31:9723-34. 2011
    ..proton-gated currents in the CNS, and activation of ASIC1a homomeric channels induces neuronal death after local acidosis that accompanies cerebral ischemia...
  28. ncbi Effects of subacute ruminal acidosis challenges on fermentation and endotoxins in the rumen and hindgut of dairy cows
    S Li
    Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada
    J Dairy Sci 95:294-303. 2012
    The effects of a grain-based subacute ruminal acidosis (SARA) challenge (GBSC) and an alfalfa-pellet SARA challenge (APSC) on fermentation and endotoxins in the rumen and in the cecum, as well as on endotoxins in peripheral blood, were ..
  29. ncbi Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells
    Jing Tong
    Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    J Immunol 186:3686-92. 2011
    ..We also demonstrated that acidosis upregulated the expression of CD11c, MHC class II, CD80, and CD86 and enhanced the Ag-presenting ability of DCs ..
  30. ncbi Unidentified acids of strong prognostic significance in severe malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Crit Care Med 32:1683-8. 2004
    ..disorders, the strong anion gap as an estimate for the contribution of unmeasured plasma anions other than lactate to the metabolic acidosis that characterizes severe falciparum malaria and to assess its relative prognostic significance.
  31. pmc Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a
    Olena Yermolaieva
    Department of Internal Medicine and Physiology, Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 101:6752-7. 2004
    ..We found that extracellular acidosis opened ASIC1a channels, which provided a pathway for Ca(2+) entry and elevated [Ca(2+)](c) in wild-type, but not ..
  32. pmc Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome
    Kristiina Rajamäki
    Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, FI 00290 Helsinki, Finland
    J Biol Chem 288:13410-9. 2013
    Local acidosis has been demonstrated in ischemic tissues and at inflammatory sites.
  33. pmc Changes in the rumen epimural bacterial diversity of beef cattle as affected by diet and induced ruminal acidosis
    R M Petri
    Agriculture and Agri Food Canada Research Centre, Lethbridge, Alberta, Canada
    Appl Environ Microbiol 79:3744-55. 2013
    ..communities of 8 cattle were profiled during the transition from a forage to a high-concentrate diet, during acidosis, and after recovery...
  34. pmc Diet-induced bacterial immunogens in the gastrointestinal tract of dairy cows: impacts on immunity and metabolism
    Guozhong Dong
    College of Animal Science and Technology, Southwest University, and Key Laboratory of Grass and Herbivores of Chongqing Beibei, Chongqing, 400716, PR China
    Acta Vet Scand 53:48. 2011
    ..As a result, ruminal acidosis, especially subacute ruminal acidosis (SARA), occurs frequently in practical dairy production...
  35. ncbi Ca2+ and acidosis synergistically lead to the dysfunction of cortical GABAergic neurons during ischemia
    Li Huang
    Department of Physiology, Bengbu Medical College, Bengbu Anhui 233000, China
    Biochem Biophys Res Commun 394:709-14. 2010
    ..Ischemia induces Ca(2+) elevation, acidosis and dysfunction in GABAergic cells...
  36. ncbi Experimental feed induction of ruminal lactic, propionic, or butyric acidosis in sheep
    A Lettat
    INRA, UR1213 Herbivores, Centre de Recherches de Clermont Ferrand Theix, F 63122 Saint Genes Champanelle, France
    J Anim Sci 88:3041-6. 2010
    A study was conducted to determine the feasibility to induce rumen acidosis with propionate, butyrate, or lactate as the major fermentation end products. Three rumen-cannulated Texel wethers were used in a 3 x 3 Latin square design...
  37. ncbi Clinical and cellular effects of hypothermia, acidosis and coagulopathy in major injury
    K Thorsen
    Department of Surgery, Stavanger University Hospital, Stavanger, Norway
    Br J Surg 98:894-907. 2011
    Hypothermia, acidosis and coagulopathy have long been considered critical combinations after severe injury. The aim of this review was to give a clinical update on this triad in severely injured patients.
  38. pmc Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis
    Bo Duan
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 31:2101-12. 2011
    ..polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. Pharmacological blockade of ASIC1a or deletion of the ASIC1 gene greatly reduces the enhancing effect of ..
  39. ncbi Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
    Johanna Chiche
    Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR, Centre A Lacassagne, Nice, France
    J Cell Mol Med 14:771-94. 2010
    ..A common feature of tumours is acidosis caused by hypoxia (low oxygen tension)...
  40. ncbi Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    D Fukumura
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 61:6020-4. 2001
    Hypoxia and acidosis are hallmarks of tumors as well as critical determinants of response to treatments. They can upregulate vascular endothelial growth factor (VEGF) in vitro...
  41. ncbi Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors
    Anthony Sebastian
    Department of Medicine and the General Clinical Research Center, University of California, San Francisco, California 94143, USA
    Am J Clin Nutr 76:1308-16. 2002
    ..Natural selection has had < 1% of hominid evolutionary time to eliminate the inevitable maladaptations consequent to the profound transformation of the human diet resulting from the inventions of agriculture and animal husbandry...
  42. ncbi Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Jürgen Bommer
    Medizinische Universitatsklinik, Heidelberg, Germany
    Am J Kidney Dis 44:661-71. 2004
    Experimental and some clinical data suggest that metabolic acidosis contributes to poor nutritional status, a strong predictor for mortality in hemodialysis patients...
  43. ncbi Ruminal acidosis in beef cattle: the current microbiological and nutritional outlook
    T G Nagaraja
    Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan 66506, USA
    J Dairy Sci 90:E17-38. 2007
    Ruminal acidosis continues to be a common ruminal digestive disorder in beef cattle and can lead to marked reductions in cattle performance...
  44. ncbi In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells
    Javier A Menendez
    Department of Medicine, Breast Cancer Translational Research Laboratory, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois 60201, USA
    J Cell Biochem 94:1-4. 2005
    ..First, MCF-7 breast cancer cells cultured in acidosis (pH 6...
  45. ncbi Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter
    Lara R Gawenis
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 282:9042-52. 2007
    ..NBC1 mutations cause proximal renal tubular acidosis in humans, consistent with its role in HCO3- absorption in the kidney...
  46. ncbi Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning
    Masashi Fujita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Physiol Heart Circ Physiol 292:H2004-8. 2007
    We have previously reported that the prolonged transient acidosis during early reperfusion mediates the cardioprotective effects in canine hearts...
  47. ncbi Extracellular acidosis triggers the maturation of human dendritic cells and the production of IL-12
    Diego Martinez
    Institute of Hematologic Research, National Academy of Medicine, National Reference Center for AIDS, and Department of Microbiology, Buenos Aires University School of Medicine, Argentina
    J Immunol 179:1950-9. 2007
    Although the development of an acidic tissue environment or acidosis is a hallmark of inflammatory processes, few studies analyze the effect of extracellular pH on immune cells...
  48. ncbi Effects of bacterial direct-fed microbials and yeast on site and extent of digestion, blood chemistry, and subclinical ruminal acidosis in feedlot cattle
    K A Beauchemin
    Research Center, Agriculture and Agri Food Canada, Lethbridge, AB, T1J 4B1, Canada
    J Anim Sci 81:1628-40. 2003
    ..to determine whether a bacterial direct-fed microbial (DFM) alone or with yeast could minimize the risk of acidosis and improve feed utilization in feedlot cattle receiving high-concentrate diets...
  49. pmc Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium
    Darrin Street
    Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, August Krogh Building, Copenhagen, Denmark
    J Physiol 566:481-9. 2005
    ..The present study demonstrated a link between interstitial H+ and K+ accumulation, which may be through the ATP-sensitive K+ channels (KATP channels), which are sensitive to changes in H+...
  50. ncbi Aquaporin-1-mediated cerebral edema following traumatic brain injury: effects of acidosis and corticosteroid administration
    Nam D Tran
    Department of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    J Neurosurg 112:1095-104. 2010
    ..that: 1) AQP-1 participates in brain water homeostasis following TBI; 2) secondary injury (for example, acidosis) alters the expression of AQP-1 and exacerbates cerebral edema; and 3) corticosteroids augment brain AQP-1 ..
  51. ncbi The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis
    Michael V Cohen
    Department of Physiology, MSB 3050, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Circulation 115:1895-903. 2007
    ..b>Acidosis also suppresses MPTP formation...
  52. ncbi cGMP/PKG pathway mediates myocardial postconditioning protection in rat hearts by delaying normalization of intracellular acidosis during reperfusion
    Javier Inserte
    Laboratory of Experimental Cardiology, Vall d Hebron University Hospital and Research Institute, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Mol Cell Cardiol 50:903-9. 2011
    ..These results demonstrate that the cGMP/PKG pathway contributes to postconditioning protection at least in part by delaying normalization of pHi during reperfusion, probably via PKG-dependent inhibition of Na(+)/H(+)-exchanger...
  53. ncbi Defining acidosis in postoperative cardiac patients using Stewart's method of strong ion difference
    Deirdre M Murray
    Paediatric Intensive Care Unit, Royal Bristol Hospital for Children, Bristol, UK
    Pediatr Crit Care Med 5:240-5. 2004
    To define the true incidence and nature of acidosis in pediatric patients postcardiac surgery, using Stewart's direct method of measuring strong ion difference...
  54. pmc Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis
    Lixue Dong
    Department of Oncology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
    PLoS ONE 8:e61991. 2013
    ..To delineate the function and signaling pathways of GPR4 activation by acidosis in endothelial cells, we compared the global gene expression of the acidosis response in primary human umbilical ..
  55. ncbi Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis
    John A Kellum
    MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Chest 125:243-8. 2004
    To determine the effects of hyperchloremic acidosis, induced by dilute HCl infusion, on BP and circulating inflammatory mediators in an experimental model of severe sepsis in the rat.
  56. ncbi Effects of a subacute ruminal acidosis model on the diet selection of dairy cows
    J E Keunen
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G2W1
    J Dairy Sci 85:3304-13. 2002
    Two experiments were conducted to study the effects of a subacute ruminal acidosis (SARA) model on diet choice in dairy cows...
  57. pmc Metabolic acidosis induced by Plasmodium falciparum intraerythrocytic stages alters blood-brain barrier integrity
    Sergine Zougbédé
    INSERM, UMRS 945, Paris, France
    J Cereb Blood Flow Metab 31:514-26. 2011
    ..Finally, we show that permeability of hCMEC/D3 cell monolayers is mediated through parasite induced metabolic acidosis, which in turns correlates with apoptosis of parasitized erythrocytes...
  58. ncbi Activation of P-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: in vivo imaging with 68Ga-labelled PET tracer
    Oliver Thews
    Institute of Physiology and Pathophysiology, University Medicine Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Eur J Nucl Med Mol Imaging 37:1935-42. 2010
    ..an important drug transporter responsible for multidrug resistance, can be strongly increased by extracellular acidosis. Here mitogen-activated protein kinases (MAPK) (p38, ERK1/2) seem to play an important role for signal ..
  59. pmc N-glycosylation of acid-sensing ion channel 1a regulates its trafficking and acidosis-induced spine remodeling
    Lan Jing
    Department of Cell Biology and Neuroscience, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    J Neurosci 32:4080-91. 2012
    ..In addition, we revealed that acidosis reduced the density and length of dendritic spines in a time- and ASIC1a-dependent manner...
  60. pmc Metabolic acidosis increases fibroblast growth factor 23 in neonatal mouse bone
    Nancy S Krieger
    Dept of Medicine, Div of Nephrology, Univ of Rochester School of Medicine, Box 675, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Renal Physiol 303:F431-6. 2012
    ..Patients with chronic kidney disease have decreased renal acid excretion leading to metabolic acidosis, which has a direct effect on bone cell activity...
  61. ncbi The use of sodium-chloride difference and chloride-sodium ratio as strong ion difference surrogates in the evaluation of metabolic acidosis in critically ill patients
    Danielle Nagaoka
    Medical Intensive Care Unit, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo 05623 010, Brazil
    J Crit Care 25:525-31. 2010
    Inorganic apparent strong ion difference (SIDai) improves chloride-associated acidosis recognition in dysnatremic patients...
  62. ncbi Succinyl-CoA:3-ketoacid CoA transferase (SCOT): cloning of the human SCOT gene, tertiary structural modeling of the human SCOT monomer, and characterization of three pathogenic mutations
    T Fukao
    Department of Pediatrics, Gifu University School of Medicine, Gifu, Gifu, 500 8076, Japan
    Genomics 68:144-51. 2000
    ..Interestingly, GS05 had the mildest clinical course reported to date and detectable levels of SCOT protein in fibroblasts...
  63. pmc A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate
    Nimrit Goraya
    Department of Internal Medicine, Texas A and M College of Medicine, Temple, Texas 76508, USA
    Clin J Am Soc Nephrol 8:371-81. 2013
    Current guidelines recommend Na(+)-based alkali for CKD with metabolic acidosis and plasma total CO2 (PTCO2) < 22 mM...
  64. ncbi The straight line hypothesis elaborated: case reference obesity, an argument for acidosis, oxidative stress, and disease conglomeration?
    Shoma Berkemeyer
    Department of Geriatrics, University of Bochum, Marienhospital Herne, Widumerstr 8, D 44627 Herne, Germany
    Med Hypotheses 75:59-64. 2010
    ..This review brings together existing literature and concepts to explain how obesity can relate to oxidative stress via protons, uniquely for itself or, as often observed, in conglomeration of additional diseases...
  65. ncbi Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro
    Tobias Cronberg
    Department of Clinical Neuroscience, Lund University, Lund, Sweden
    Stroke 35:753-7. 2004
    ..Elevated preischemic glucose levels, lactate production, and intracerebral acidosis correlate with increased brain damage...
  66. ncbi Correction of metabolic acidosis to ameliorate wasting in chronic kidney disease: goals and strategies
    Yi Wen Chiu
    Division of Nephrology, Department of Internal Medicine, at Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Semin Nephrol 29:67-74. 2009
    Metabolic acidosis is an important cause of protein-energy wasting, commonly observed in chronic kidney disease (CKD)...
  67. ncbi Comparison of sevelamer hydrochloride and sevelamer carbonate: risk of metabolic acidosis and clinical implications
    Ashwini B Pai
    Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
    Pharmacotherapy 29:554-61. 2009
    ..However, reported drawbacks of this agent are metabolic acidosis, high pill burden, and a relatively low affinity and selectivity for phosphate anions...
  68. ncbi Acidosis-induced relaxation of human internal mammary artery is due to activation of ATP-sensitive potassium channels
    Dileep Kumar Rohra
    Department of Biological and Biomedical Sciences, Faculty of Health Sciences, The Aga Khan University, Stadium Road, P O Box 3500, Karachi 74800, Pakistan
    Eur J Pharmacol 514:175-81. 2005
    Metabolic acidosis is associated with various clinical situations including diabetes mellitus and renal diseases...
  69. ncbi Selective sparing of hippocampal CA3 cells following in vitro ischemia is due to selective inhibition by acidosis
    Tobias Cronberg
    Department of Clinical Neuroscience, Wallenberg Neuroscience Center, Laboratory for Experimental Brain Research, Lund University, BMC A13, S 221 84 Lund, Sweden
    Eur J Neurosci 22:310-6. 2005
    ..As acidosis develops during ischemia, we studied the importance of extracellular pH for selective vulnerability...
  70. ncbi α1-Adrenergic responsiveness in human skeletal muscle feed arteries: the impact of reducing extracellular pH
    Stephen J Ives
    Geriatric Research, Education and Clinical Center, George E Whalen VA Medical Center, Salt Lake City, UT, USA
    Exp Physiol 98:256-67. 2013
    ..4 = 88 ± 13, pH 7.1 = 67 ± 8, pH 6.8 = 67 ± 9 and pH 6.5 = 58 ± 8% KCl(max)). Graded acidosis had no effect on maximal vasorelaxation...
  71. ncbi Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption
    Petra Frings-Meuthen
    German Aerospace Center DLR, Institute of Aerospace Medicine, Cologne, Germany
    J Bone Miner Res 23:517-24. 2008
    Stepwise increase in NaCl intake in healthy male test subjects led to a low-grade metabolic acidosis. This was most likely the cause for increased bone resorption during high sodium chloride intake, as determined by analyzing bone ..
  72. pmc Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts
    Svetlana V Komarova
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5C1
    Proc Natl Acad Sci U S A 102:2643-8. 2005
    Systemic acidosis has detrimental effects on the skeleton, and local acidosis coincides with bone destruction in inflammatory and metastatic diseases...
  73. pmc Acid-sensing ion channels in acidosis-induced injury of human brain neurons
    Minghua Li
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Cereb Blood Flow Metab 30:1247-60. 2010
    b>Acidosis is a common feature of the human brain during ischemic stroke and is known to cause neuronal injury. However, the mechanism underlying acidosis-mediated injury of the human brain remains elusive...
  74. ncbi Acidosis and raised norepinephrine levels are associated with exercise dyspnoea in idiopathic pulmonary fibrosis
    Keisuke Miki
    Department of Internal Medicine, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan
    Respirology 14:1020-6. 2009
    ..This study tested the hypothesis in IPF that exertional dyspnoea correlates with cardiopulmonary exercise responses, specifically changes in arterial blood pH and plasma norepinephrine (NE)...
  75. ncbi Delayed recovery of intracellular acidosis during reperfusion prevents calpain activation and determines protection in postconditioned myocardium
    Javier Inserte
    Laboratorio de Cardiologia Experimental, Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Passeig Vall d Hebron, 119 129, 08035 Barcelona, Spain
    Cardiovasc Res 81:116-22. 2009
    ..We sought to characterize the effect of ischaemic postconditioning on pHi recovery during reperfusion and on calpain-dependent proteolysis, an important mechanism of myocardial reperfusion injury...
  76. ncbi Acidosis, hypoxia and bone
    Timothy R Arnett
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Arch Biochem Biophys 503:103-9. 2010
    ..Bone cells are extremely sensitive to the direct effects of pH: acidosis inhibits mineral deposition by osteoblasts but it activates osteoclasts to resorb bone and other mineralised ..
  77. ncbi Subacute ruminal acidosis (SARA) in grazing Irish dairy cows
    Luke O'Grady
    School of Agriculture, Food Science and Veterinary Medicine, Unit of Herd and Veterinary Public Health, University College Dublin, Belfield, Dublin 4, Ireland
    Vet J 176:44-9. 2008
    Subacute ruminal acidosis (SARA) is a significant production disease of dairy cattle. Previous concerns have been raised over the occurrence of SARA in pasture-fed dairy cattle and the potential consequences of laminitis and lameness...
  78. pmc Sodium acetate infusion in critically ill trauma patients for hyperchloremic acidosis
    Andrew McCague
    Department of Surgery, Arrowhead Regional Medical Center, Colton, California, USA
    Scand J Trauma Resusc Emerg Med 19:24. 2011
    ..The primary purpose of the study is to analyze the effect of sodium acetate on hemodynamic parameters. Secondarily we looked at the effects on prevention and treatment of hyperchloremic metabolic acidosis.
  79. ncbi Reduction of beta-amyloid-induced neurotoxicity on hippocampal cell cultures by moderate acidosis is mediated by transforming growth factor beta
    R Uribe-San Martín
    Department of Neurology, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    Neuroscience 158:1338-47. 2009
    ..microvascular alterations, which can induce impairment of brain perfusion because of vascular pathology and local acidosis. Acidosis can promote amyloidogenesis, which could further contribute to neurodegenerative changes...
  80. ncbi Acidosis induces relaxation mediated by nitric oxide and potassium channels in rat thoracic aorta
    Andrea C Celotto
    Laboratory of Endothelial Function, Department of Surgery and Anatomy, School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Eur J Pharmacol 656:88-93. 2011
    ..The effect of extracellular acidosis (pH 7.0 and 6...
  81. ncbi Effects of bacterial direct-fed microbials on ruminal fermentation, blood variables, and the microbial populations of feedlot cattle
    G R Ghorbani
    Research Center, Agriculture and Agri Food Canada, Lethbridge, AB
    J Anim Sci 80:1977-85. 2002
    ..was conducted to determine whether bacterial direct-fed microbials (DFM) could be used to minimize the risk of acidosis in feedlot cattle receiving high concentrate diets...
  82. ncbi Changes in tissue pH and temperature after incision indicate acidosis may contribute to postoperative pain
    Young Cheol Woo
    Department of Anesthesia, University of Iowa, 200 Hawkins Drive, 6 JCP, Iowa City, Iowa 52242, USA
    Anesthesiology 101:468-75. 2004
    ..In this study, the authors measured tissue pH and hind paw temperature before and after incision to understand factors that may activate and sensitize nociceptors in the incision...
  83. ncbi A survey of intravenous sodium bicarbonate in neonatal asphyxia among European neonatologists: gaps between scientific evidence and clinical practice
    Pilar Saenz
    Division of Neonatology, University Hospital La Fe, Valencia, Spain
    Neonatology 99:170-6. 2011
    Birth asphyxia is characterized by intermittent periods of hypoxia/ischemia leading to metabolic acidosis. The use of intravenous sodium bicarbonate (IVSB) is still a matter of controversy in clinical practice.
  84. ncbi Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage
    Javier Inserte
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, Barcelona, Spain
    Cardiovasc Res 77:782-90. 2008
    It has been proposed that intracellular acidosis may be the basis of the cardioprotection of different interventions, including postconditioning...
  85. ncbi Topiramate and metabolic acidosis in infants and toddlers
    Heike Philippi
    Department of Pediatrics, Johannes Gutenberg University, Mainz, Germany
    Epilepsia 43:744-7. 2002
    Topiramate (TPM) inhibits carbonic anhydrase, with metabolic acidosis as a possible side effect, although this has been reported in only two adult cases. We investigated the acid-base metabolism in infants and toddlers treated with TPM.
  86. ncbi Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis
    Yi Fen Lo
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Kidney Int 79:730-41. 2011
    ..electrogenic sodium bicarbonate cotransporter 1 (NBC1) in a patient with isolated proximal renal tubular acidosis (pRTA)...
  87. pmc Consequences and therapy of the metabolic acidosis of chronic kidney disease
    Jeffrey A Kraut
    Medical and Research Services, VHAGLA Healthcare System, UCLA Membrane Biology Laboratory, Los Angeles, CA, USA
    Pediatr Nephrol 26:19-28. 2011
    Metabolic acidosis is common in patients with chronic kidney disease (CKD), particularly once the glomerular filtration rate (GFR) falls below 25 ml/min/1.73 m(2)...
  88. pmc Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels
    Fabrice Dabertrand
    University of Vermont College of Medicine, Department of Pharmacology, 89 Beaumont Avenue, B 303 Given Building, Burlington, VT 05405 0068, USA
    Circ Res 110:285-94. 2012
    b>Acidosis is a powerful vasodilator signal in the brain circulation. However, the mechanisms by which this response occurs are not well understood, particularly in the cerebral microcirculation...
  89. ncbi Mechanisms in hyperkalemic renal tubular acidosis
    Fiona E Karet
    Cambridge Institute for Medical Research Room 4 3, Addenbrooke s Hospital Box 139, Hills Road, Cambridge, CB2 0XY, UK
    J Am Soc Nephrol 20:251-4. 2009
    The form of renal tubular acidosis associated with hyperkalemia is usually attributable to real or apparent hypoaldosteronism...
  90. ncbi Impact of laparoscopic gases on peritoneal microenvironment and essential parameters of cell function
    P Wildbrett
    Department of Surgery, Humboldt University Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Surg Endosc 17:78-82. 2003
    ....
  91. ncbi Treatment of metabolic acidosis
    Jacques Levraut
    Departemente d Anesthesie Reanimation Est, Hopital Saint Roch 5, rue Pierre Devoluy, F 06006, Nice
    Curr Opin Crit Care 9:260-5. 2003
    Metabolic acidosis is characterized by a decrease of the blood pH associated with a decrease in the bicarbonate concentration...
  92. ncbi Role of endothelial nitric oxide and smooth muscle potassium channels in cerebral arteriolar dilation in response to acidosis
    Tetsuyoshi Horiuchi
    Department of Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 33:844-9. 2002
    Potassium channels or nitric oxide or both are major mediators of acidosis-induced dilation in the cerebral circulation. However, these contributions depend on a variety of factors such as species and vessel location...
  93. ncbi Comparison of blood gas and acid-base measurements in arterial and venous blood samples in patients with uremic acidosis and diabetic ketoacidosis in the emergency room
    Y Gokel
    Department of Emergency, Faculty of Medicine, Cukurova University, Adana, Turkey
    Am J Nephrol 20:319-23. 2000
    ..The aim of this study was to examine a plausible correlation between venous and arterial blood gas values in acidotic patients with chronic uremia or diabetic ketoacidosis (DKA)...
  94. ncbi Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study
    Danilo T Noritomi
    Intensive Care Unit, Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil
    Crit Care Med 37:2733-9. 2009
    To describe the composition of metabolic acidosis in patients with severe sepsis and septic shock at intensive care unit admission and throughout the first 5 days of intensive care unit stay.
  95. ncbi The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy
    Katie DeClerck
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, PO Box 19629, Springfield, IL 62794, USA
    Front Biosci (Landmark Ed) 15:213-25. 2010
    By a multiplicity of mechanisms, hypoxia and acidosis create a nurturing environment for tumor progression and the evolution of metastatic, drug-resistant cells...
  96. pmc The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior
    Adam E Ziemann
    Medical Scientist Training Program, Department of Molecular Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Cell 139:1012-21. 2009
    ..These data identify the amygdala as an important chemosensor that detects hypercarbia and acidosis and initiates behavioral responses...
  97. pmc Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells
    O K Schlappack
    Ontario Cancer Institute, University of Toronto, Canada
    Br J Cancer 64:663-70. 1991
    ..to conditions of acid pH and nutrient deprivation, as well as hypoxia, we have examined the effect of exposure to acidosis (pH 6...
  98. pmc Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity
    M Cristina D'Adamo
    Section of Human Physiology, University of Perugia School of Medicine, Perugia 06100, Italy
    J Biol Chem 286:192-8. 2011
    ..These results identify Kir5.1 as an important determinant of PCO(2)/pH sensitivity in locus coeruleus neurons and suggest that Kir5.1 may be involved in the response to hypercapnic acidosis.
  99. ncbi Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease
    Joseph A Eustace
    Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Kidney Int 65:1031-40. 2004
    ..Low serum albumin is a strong risk factor for mortality, but its association with low serum bicarbonate and inflammation in the setting of mild to moderately decreased kidney function is uncertain...
  100. ncbi Pendrin in the mouse kidney is primarily regulated by Cl- excretion but also by systemic metabolic acidosis
    Patricia Hafner
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, Zurich CH 8057, Switzerland
    Am J Physiol Cell Physiol 295:C1658-67. 2008
    ..The abundance of pendrin is reduced during metabolic acidosis induced by oral NH(4)Cl loading...
  101. ncbi Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    Johanna Chiche
    Institute of Developmental Biology and Cancer Research University of Nice, Centre National de la Recherche Scientifique UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, Nice, France
    Cancer Res 69:358-68. 2009
    b>Acidosis of the tumor microenvironment is typical of a malignant phenotype, particularly in hypoxic tumors...

Research Grants72

  1. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..Knockout of the KCC4 gene in mice results in distal renal tubular acidosis. Regulation of these cotransporters remains incompletely understood, but recent evidence suggests that the WNK ..
  2. Complex I: Role of L Subunit in Proton Translocation
    Steven B Vik; Fiscal Year: 2011
    ..as Leber's hereditary optic neuropathy (LHON), Leigh disease, and mitochondrial encephalomyopathy and lactic acidosis with stroke-like episodes (MELAS)...
  3. Structural biology of enzymes in fatty acid metabolism
    Liang Tong; Fiscal Year: 2012
    ..PC deficiency is linked to lactic acidosis and mental retardation in humans...
  4. Characterization of an essential mitochondrial rRNA methyltransferase
    Kip E Guja; Fiscal Year: 2013
    ..gene expression can cause a myriad of mitochondrial disorders, including mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome, Kearns-Sayre syndrome, and Leber hereditary optic neuropathy...
  5. Mediators &prognostic value of muscle mass &function in chronic kidney disease
    Francis Perry Wilson; Fiscal Year: 2013
    ..Anemia, acidosis, decreased protein intake, and decreased physical activity may associate with greater declines in muscle mass ..
  6. Control of Renal Glutaminase Expression during Acidosis
    Norman P Curthoys; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Metabolic acidosis is a pronounced disturbance in acid-base balance that is caused by genetic or acquired defects in metabolism, in renal handling of bicarbonate, and in the excretion of titratable ..
  7. STRUCTURE OF THE VACUOLAR ATPase
    Stephan Wilkens; Fiscal Year: 2013
    ..Defects in the human vacuolar ATPase have been associated with a number of diseases such as renal tubular acidosis, sensorineural deafness, osteoporosis, diabetes and cancer...
  8. Sodium Chloride Cotransporter Regulation by WNK Kinase
    Hui Cai; Fiscal Year: 2010
    ..PHA II is a rare autosomal dominant disorder featuring hypertension, hyperkalemia and metabolic acidosis. Its clinical features are reversed by a thiazide diuretic, a sodium chloride cotransporter (NCC) inhibitor...
  9. Kinetics of DNA polymerase gamma upon mutation and nucleoside analog exposure
    CHRISTAL DYANE SOHL; Fiscal Year: 2013
    ..Symptoms similar to those seen in progressive external ophthalmoplegia can result, as well as lactic acidosis and lipodystrophy, and toxicity can be severe enough to require the halt of this type of treatment...
  10. Validation in Baboon Model of Broadband NIR Monitoring for Neonate Gut Perfusion
    David A Benaron; Fiscal Year: 2012
    ..of monitoring such as arterial blood pressure, heart rate, pulse oximetry, urine output and evidence of metabolic acidosis. However, these parameters may be delayed or misleading in the detection of poor tissue perfusion...
  11. Insulin Resistance in Chronic Kidney Disease
    Ian H De Boer; Fiscal Year: 2013
    ..commonly acquired due to unique metabolic abnormalities, including impaired renal calcitriol synthesis, metabolic acidosis, and accumulation of uremic toxins...
  12. Role of Astrocytic TREK-2 Potassium Channels in Cerebral Ischemia
    Misty J Eaton; Fiscal Year: 2013
    ..TREK-2 channels are activated by polyunsaturated fatty acids, intracellular acidosis in the physiological range and by mechanical stretch...
  13. MOLECULAR MECHANISMS FOR EXTRACELLULAR PH CONTROL DURING AMELOGENESIS
    MICHAEL LANSDELL PAINE; Fiscal Year: 2013
    ..in patients with disease states impacting pH homeostasis;conditions such as inherited proximal renal tubular acidosis (pRTA) and cystic fibrosis (CF)...
  14. Enzymology of RNA Processing
    Carol A Fierke; Fiscal Year: 2013
    ..as mitochondria dysfunction which manifests clinically as MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like symptoms), progressive external opthalmoplegia and/or diabetes...
  15. ELECTROPHYSIOLOGY OF NEONATAL AND ADULT HEART
    Martin Morad; Fiscal Year: 2013
    ..an important role in apoptosis, cardiomyopathy, ischemia-reperfusion injury, Leigh syndrome, and fatal infantile acidosis, it is likely that such a specific mitochondrial Ca2+ -signaling pathway plays a critical role in these ..
  16. Detection and Quantification of Neonatal Intraventricular Hemorrhage
    Michael D Weiss; Fiscal Year: 2013
    ..While some neonates exhibit clear outward signs related to IVH such as apnea, pallor, seizures and metabolic acidosis, up to 50 percent of IVHs may be clinically silent...
  17. Protein intake, nutrition and cardiovascular disease in stage V CKD
    Srinivasan Beddhu; Fiscal Year: 2011
    ..serum protein levels is not the result of decreased dietary intake, rather hypercatabolism induced by metabolic acidosis, inflammation and oxidative stress...
  18. Role of Serotonin in Smypathetic Function
    Karie E Scrogin; Fiscal Year: 2012
    ..Experiments will be conducted to test the hypothesis that caudal hindbrain serotonergic neurons activated by acidosis, stimulate 5-HT1A receptors to promote sympathetic-mediated venoconstriction of the splanchnic vascular bed ..
  19. Mechanisms of Degenerative Cell Death in C. elegans
    MONICA A DRISCOLL; Fiscal Year: 2013
    ..underlies the pathology of many neurodegenerative diseases and is an incapacitating outcome of stroke, ischemia, acidosis, and physical injury...
  20. Mechanisms of transcription initiation in mitochondria
    Dmitry Temiakov; Fiscal Year: 2013
    ..in mtDNA expression result in a number of myopathies such as MELAS (mitochondrial encephalomyopath, lactic acidosis, and stroke-like syndrome), MERRF (myoclonic epilepsy with ragged red fibers syndrome), hearing and vision loss, ..
  21. Regulation of Renal Maxi K Channel by WNK Kinase
    Hui Cai; Fiscal Year: 2013
    ..as Gordon syndrome, is an autosomal dominant disorder, characterized by hypertension, hyperkalemia, and metabolic acidosis (6)...
  22. 2012 Iron Sulfur Enzymes Gordon Research Conference
    Markus W Ribbe; Fiscal Year: 2012
    ..iron sulfur clusters and proteins causes a range of rare and serious diseases, ranging from infantile lactic acidosis and seizures to Friedreich ataxia, a disease in which patients survive until early adulthood, and ISCU myopathy, ..
  23. Developmental Pharmacology of cytosolic and mitochondrial GSTZ1-1/MAAI
    PETER WALLACE STACPOOLE; Fiscal Year: 2013
    ..This is important because while DCA has therapeutic benefits in treating certain solid tumors, lactic acidosis and pulmonary arterial hypertension, it exhibits marked individual variability in pharmacokinetics, and can cause ..
  24. Thiamine as a Metabolic Resuscitator in Septic Shock
    Michael William Donnino; Fiscal Year: 2012
    ..Septic shock may be characterized by hypotension, high metabolic state, lactic acidosis and potentially death...
  25. Neuropeptide Modulation of ASICs
    Candice C Askwith; Fiscal Year: 2012
    ..My laboratory is interested in understanding how ASIC1a contributes to acidosis-induced neuronal damage. Recently, we discovered that dynorphins prevent ASIC1a desensitization...
  26. Safety and Effectiveness Evaluations for Diabetes
    DONALD READ MILLER; Fiscal Year: 2013
    ..evaluate risks of various other adverse events associated with diabetes medications, including risk of lactic acidosis associated with metformin use, particularly in patients with early kidney disease or heart failure, risk of ..
  27. The distinct roles of AMPK in neurons and astrocytes following stroke
    Jun Li; Fiscal Year: 2013
    ..processes by up-regulation of neuronal AMPK during severe ischemia would propagate metabolic failure and acidosis. In contrast, astrocytes can perform glycolysis, oxidize fatty acids to form ketones, and store some glycogen ..
  28. Acid-base status and the development of hypertension and diabetes
    Eric N Taylor; Fiscal Year: 2012
    ..acid-base status, hypertension, and diabetes were cross-sectional, it is unknown whether low-grade metabolic acidosis is a cause or a consequence of these diseases...
  29. Modulation of Monocarboxylic Acid Transporter Kinetic Function for Stroke Therapy
    JEFFREY PAUL SMITH; Fiscal Year: 2010
    ..pathological conditions such as ischemic stroke, hyperglycemic stroke, and brain injury, where brain lactic acidosis has been shown to be a key indicator in the etiology of cell damage...
  30. US-China Collaborative Research on Stroke Imaging
    Jinyuan Zhou; Fiscal Year: 2013
    ..This totally noninvasive pH imaging method can identify regions of tissue acidosis following impaired aerobic metabolism...
  31. Role of Collecting Duct Chloride Transporters in Volume Regulation
    Manoocher Soleimani; Fiscal Year: 2013
    ..of Cl-/HCO3- exchangers PAT2 or AE1 by physiologic maneuvers can mitigate the severity of distal renal tubular acidosis in AE1 or PAT2 null mice, respectively...
  32. Pyruvate Dehydrogenase E1: Structure-Function Studies
    William F Furey; Fiscal Year: 2012
    ..for example, beri-beri, maple syrup urine disease, Pyruvate Dehydrogenase Deficiency (PDHA) associated lactic acidosis, microcephaly, motor neuropathy, Leigh syndrome, and neurological diseases including Alzheimer's and ..
  33. Mechanisms of Kinase-dependent Regulation of the V-ATPase in Kidney
    NURIA M PASTOR-SOLER; Fiscal Year: 2013
    ..with defective V-ATPase activity in kidney intercalated cells (ICs) may suffer from severe chronic metabolic acidosis with potential severe sequelae in bone, kidney, and other organs...
  34. Targeted Therapies for Selected Phenotypes of Obstructive Sleep Apnea
    Jerome A Dempsey; Fiscal Year: 2010
    ..Increasing respiratory motor output and reducing plant gain via carbonic anhydrase inhibition (and mild metabolic acidosis) will eliminate central apneas and significantly reduce obstructed and mixed apneas in subjects with a narrowed ..
  35. BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULE
    George J Schwartz; Fiscal Year: 2013
    ..Metabolic acidosis converts the collecting duct from net HCO3- secretion to HCO3- absorption (H+ secretion)...
  36. Risk Factors for the Development of Lactic Acidosis and Pancreatitis Among HAART-
    William Wester; Fiscal Year: 2011
    ..polymerase-gamma has been associated with several long-term mitochondrial toxicities;these include lactic acidosis, pancreatitis, peripheral neuropathy, and peripheral fat wasting/atrophy...
  37. Effect of Thiamine on Pyruvate Dehydrogenase Activity in Septic Shock
    Michael William Donnino; Fiscal Year: 2013
    ..Septic shock is characterized by hypotension, high metabolic state, lactic acidosis and potentially death...
  38. NanoSPINs for In Vivo EPR-Based Spectroscopy and Imaging
    Valery V Khramtsov; Fiscal Year: 2010
    ..SA3) To study the role of myocardial acidosis and NO generation in ischemic hearts and in the model of ischemic preconditioning using developed nanoSPINs...
  39. Increased sodium dependent glucose transport in the ischemic brain
    Thomas J Abbruscato; Fiscal Year: 2013
    ..Increased glucose supply post ischemic attack has also been associated with cellular acidosis and free radical generation which can exacerbate edema...
  40. Regulation of proton pump trafficking in kidney
    Dennis Brown; Fiscal Year: 2013
    Defects in V-ATPase-dependent acidification in the kidney collecting duct results in distal tubular acidosis and nephrolithiasis...
  41. North American Mitochondrial Disease Consortium (NAMDC)
    JOHN L THOMPSON; Fiscal Year: 2013
    ..spectroscopy to assess metabolites in muscle and brain of patients with mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS)...
  42. Transfusion in Malaria
    Walter H Dzik; Fiscal Year: 2013
    ..Secondly, lactic acidosis accompanies severe malaria anemia and is a strong predictor of fatal outcome...
  43. MITOCHONDRIAL ENCEPHALOMYOPATHIES AND MENTAL RETARDATION
    Salvatore DiMauro; Fiscal Year: 2013
    ..associated with mitochondrial DNA (mtDNA) point mutations, especially mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). In Project I, Dr...
  44. Acid-sensing channels as novel target for brain ischemia
    Zhigang Xiong; Fiscal Year: 2009
    ..that activation of acid-sensing ion channels (ASICs), and subsequent Ca2+ entry are largely responsible for acidosis- mediated, glutamate receptor-independent ischemic brain injury...
  45. Spin Probes in Semipermeable Nanospheres: EPR spectroscopy & imaging of tumor pH
    VALERY KHRAMTSOV; Fiscal Year: 2009
    ..mammary tumors in living mice are planned to contribute to the understanding of the mechanisms of extracellular acidosis in solid tumors and to use extracellular pH to monitor tumor progression and thus evaluate the efficacy of anti-..
  46. Establishment of fast pH MRI for imaging metabolic injury during acute stroke
    Phillip Zhe Sun; Fiscal Year: 2013
    ..Tissue acidosis is closely associated with tissue oxygen/glucose metabolism, and may provide a metabolic biomarker for defining ..
  47. Cellular Signaling and Kidney Function
    Douglas Eaton; Fiscal Year: 2009
    ..Project 3, "Insulin Signaling and Muscle Protein Turnover in Acidosis", examines the mechanisms of muscle wasting associated with renal disease...
  48. CHEMOSENSORY TRANSDUCTION IN TASTE CELLS
    Stephen D Roper; Fiscal Year: 2012
    ..Inflammatory tissue acidosis is a major cause of pain...
  49. Dynamics of pH Regulation in the Brain
    Mitchell Chesler; Fiscal Year: 2012
    ..The third aim seeks to clarify their functional relevance in response to acidosis, repetitive firing, and hypoxic-ischemic insults...
  50. Roles of peripheral and central respiratory chemoreceptors in inbred rat strains
    MATTHEW ROBERT HODGES; Fiscal Year: 2010
    ..possibility using a combined in vivo and in vitro approach by first measuring the ventilatory response to focal acidosis in chemosensitive regions in adult BN and SS rats, and then by quantifying the cellular C02/pH sensitivity of ..
  51. Toxins as molecular probes of pain transduction mechanisms
    JEREMIAH OSTEEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tissue acidosis is known to accompany tissue injury, ischemia, and other pathophysiological events, and is thought to contribute to the perception of pain in these contexts...
  52. Dietary Acid Load, Subclinical Acidosis and Outcomes in Chronic Kidney Disease
    Julia J Scialla; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Metabolic acidosis is a modifiable risk factor for chronic kidney disease (CKD) progression...
  53. Roles of peripheral and central respiratory chemoreceptors in inbred rat strains
    MATTHEW ROBERT HODGES; Fiscal Year: 2013
    ..We will also determine the relative effects of creating focal acidosis in brainstem regions harboring these neuronal subpopulations in BN and SS rats in vivo...
  54. Regulation of Energy Metabolism by PDP1 and PDP2
    Kirill M Popov; Fiscal Year: 2012
    ..suggests that control over the phosphorylation state of PDC becomes critically important in starvation, metabolic acidosis, ischemia, and diabetes...
  55. Structure/function analysis of the na/bicarbonate cotransporters
    Inyeong Choi; Fiscal Year: 2011
    ..Altered activities of NBCe cause severe proximal renal tubule acidosis as well as glaucoma and cataracts...
  56. THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
    Alan M Weinstein; Fiscal Year: 2013
    ..Major metabolic derangements, such as hyperkalemia and acidosis, alter renal medullary solutes and thus influence urine composition;this will be the first effort to simulate ..
  57. Involvement of astrocytic two-pore domain K+ channels in ischemic pathology
    Min Zhou; Fiscal Year: 2013
    ..stimuli, including cerebral-ischemia-produced-neuronal-injury-factors (CIPNJFs), such as hypoxia, hypoglycemia, acidosis and pathological release of neurotransmitters...
  58. Mitochondrial Hsp90s Regulation of Tumor Bioenergetics and Metastasis
    MARIA CECILIA CAINO; Fiscal Year: 2013
    ..g. nutrient deprivation, acidosis and hypoxia) and to the acquisition of new malignant properties...
  59. ASIC Channels and Pain
    David Julius; Fiscal Year: 2013
    ..Tissue acidosis (i.e...
  60. MODULATION AND REGULATION OF ROMK CHANNELS IN KIDNEY
    WenHui Wang; Fiscal Year: 2013
    ..an autosomal dominant disease characterized by salt-sensitive hypertension, hyperkalemia and renal tubule acidosis (Pseudohypoaldosteronism type II)...
  61. Comparison between pH regulation in chemosensitive vs nonchemosensitive neurons
    VERNON A RUFFIN; Fiscal Year: 2010
    ..comparing the response to acid/ base disturbances in HC and MR neurons saw similar results during respiratory acidosis, respiratory alkalosis, and metabolic alkalosis ...
  62. Alkali Therapy in Chronic Kidney Disease
    THOMAS HEARD HOSTETTER; Fiscal Year: 2012
    ..Such definition would be critical to any larger trial. Despite the well recognized coincidence of acidosis and CKD and the accumulated evidence of deleterious effects of acidosis, treatment of acidosis has been very ..
  63. HYPOGLYCEMIC ACTION OF 2-CHLOROPROPIONATE
    Robert Harris; Fiscal Year: 1980
    ..2-chloropropionate and to investigate the possible use of this compound in the treatment of hyperglycemia, lactic acidosis, and hyperlipoproteinemia...
  64. SURGICAL STUDIES OF SEVERE RESPIRATORY FAILURE
    Joseph Zwischenberger; Fiscal Year: 2004
    ..Adverse effects of permissive hypercapnia and the associated respiratory acidosis include increased cardiac output, organ blood flow and intracranial pressure...
  65. Utilizing Ethyl Nitrate Gas in Laparoscopic Surgery
    James Reynolds; Fiscal Year: 2006
    ..project is to evaluate the ability of ethyl nitrate to attenuate the reduced tissue perfusion and respiratory acidosis produced during carbon dioxide pneumoperitoneum...
  66. A Transcutaneous Gas Sensor for Noninvasive Diagnosis of Necrotizing Enterocoliti
    OOMMAN VARGHESE; Fiscal Year: 2009
    ..Measurement of the transcutaneous gases will be used for detecting possible acidosis and necrotizing enterocolitis (NEC)...
  67. Cell adhesion molecules in cerebral malaria.
    Henri van der Heyde; Fiscal Year: 2005
    ..individuals develop impaired consciousness with posturing (cerebral malaria), respiratory distress with lactic acidosis, anemia and (rarely) acute nephritis...
  68. Investigation of the Molecular Determinants of DAX-1 Mediated X-Linked Adrenal Hy
    Christina Tzagarakis Foster; Fiscal Year: 2009
    ..If untreated, adrenal insufficiency is rapidly lethal as a result of acidosis, hypoglycemia, and shock. The AHC locus was originally mapped to the Xp21 region of the X chromosome...
  69. PH AND MYOCARDIAL CONTRACTILITY
    Donghee Kim; Fiscal Year: 1992
    Changes in intracellular pH occur under pathophysiologic conditions such as myocardial ischemia, hypoxia or acidosis that are associated with depressed myocardial function...
  70. Early Enterocyte Injury in Neonatal Necrotizing Enterocolitis
    ERIKA CLAUD; Fiscal Year: 2009
    ..I hypothesize that PAF induces intracellular acidosis via a Ca2+ dependent Cl- channel and that PAF induced intracellular acidosis results in apoptosis of intestinal ..
  71. PH CONTROL OF PROTEIN SYNTHESIS
    Peter Garlick; Fiscal Year: 2003
    ..Moreover, they are also susceptible to body protein wasting. Experimental acidosis has been shown to result in negative nitrogen balance, and body protein loss in acidotic patients can be ..
  72. RENAL AMMONIAGENESIS: 15NH3 STUDIES WITH GC-MS
    Itzhak Nissim; Fiscal Year: 1990
    ..The work will address five primary themes: (1) the metabolic signals initiating augmented ammoniagenesis in acidosis; (2) the rate limiting metabolic pathway(s) for ammonia production; (3) the role of effectors and/or inhibitors ..