sleep deprivation

Summary

Summary: The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.

Top Publications

  1. pmc Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
    Janet M Mullington
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School Division of Cardiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA
    Prog Cardiovasc Dis 51:294-302. 2009
  2. ncbi Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite
    Karine Spiegel
    University of Chicago, Chicago, Illinois, USA
    Ann Intern Med 141:846-50. 2004
  3. pmc Meta-analysis of short sleep duration and obesity in children and adults
    Francesco P Cappuccio
    Clinical Sciences Research Institute, University of Warwick Medical School, Coventry, UK
    Sleep 31:619-26. 2008
  4. pmc Short sleep duration and weight gain: a systematic review
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Obesity (Silver Spring) 16:643-53. 2008
  5. ncbi Age-related changes in the time course of vigilant attention during 40 hours without sleep in men
    Martin Adam
    Institute of Pharmacology and Toxicology and Center for Integrative Human Physiology CIHP, University of Zurich, Switzerland
    Sleep 29:55-7. 2006
  6. ncbi Mortality associated with sleep duration and insomnia
    Daniel F Kripke
    Department of Psychiatry 0667, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0667, USA
    Arch Gen Psychiatry 59:131-6. 2002
  7. pmc Behavioral and physiological consequences of sleep restriction
    Siobhan Banks
    Division of Sleep and Chronobiology, Department ofPsychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Sleep Med 3:519-28. 2007
  8. ncbi Sleep duration and mortality: a systematic review and meta-analysis
    Lisa Gallicchio
    The Prevention and Research Center, The Weinberg Center for Women s Health and Medicine, 227 St Paul Place, 6th Floor, Baltimore, MD 21202, USA
    J Sleep Res 18:148-58. 2009
  9. ncbi Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey
    James E Gangwisch
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Hypertension 47:833-9. 2006
  10. ncbi A prospective study of sleep duration and coronary heart disease in women
    Najib T Ayas
    Division of Pulmonary Medicine, Department of Medicine, Vancouver General Hospital, 2775 Heather St, Vancouver, British Columbia, Canada V5Z 3J5
    Arch Intern Med 163:205-9. 2003

Detail Information

Publications324 found, 100 shown here

  1. pmc Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
    Janet M Mullington
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School Division of Cardiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA
    Prog Cardiovasc Dis 51:294-302. 2009
    ..and inflammation with particular emphasis on experimental sleep loss, using models of total and partial sleep deprivation, in healthy individuals who normally sleep in the range of 7 to 8 hours and have no sleep disorders...
  2. ncbi Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite
    Karine Spiegel
    University of Chicago, Chicago, Illinois, USA
    Ann Intern Med 141:846-50. 2004
    Total sleep deprivation in rodents and in humans has been associated with hyperphagia. Over the past 40 years, self-reported sleep duration in the United States has decreased by almost 2 hours.
  3. pmc Meta-analysis of short sleep duration and obesity in children and adults
    Francesco P Cappuccio
    Clinical Sciences Research Institute, University of Warwick Medical School, Coventry, UK
    Sleep 31:619-26. 2008
    ..Recent epidemiological studies suggest that short sleep duration may be associated with the development of obesity from childhood to adulthood...
  4. pmc Short sleep duration and weight gain: a systematic review
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Obesity (Silver Spring) 16:643-53. 2008
    The recent obesity epidemic has been accompanied by a parallel growth in chronic sleep deprivation. Physiologic studies suggest sleep deprivation may influence weight through effects on appetite, physical activity, and/or ..
  5. ncbi Age-related changes in the time course of vigilant attention during 40 hours without sleep in men
    Martin Adam
    Institute of Pharmacology and Toxicology and Center for Integrative Human Physiology CIHP, University of Zurich, Switzerland
    Sleep 29:55-7. 2006
    ..To examine whether vigilant attention and sleepiness develop differently during prolonged wakefulness in young and older men...
  6. ncbi Mortality associated with sleep duration and insomnia
    Daniel F Kripke
    Department of Psychiatry 0667, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0667, USA
    Arch Gen Psychiatry 59:131-6. 2002
    ..Treatment strategies may be guided by what sleep durations predict optimal survival and whether insomnia might signal mortality risks...
  7. pmc Behavioral and physiological consequences of sleep restriction
    Siobhan Banks
    Division of Sleep and Chronobiology, Department ofPsychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Sleep Med 3:519-28. 2007
    ..daytime cognitive dysfunction accumulates to levels comparable to that found after severe acute total sleep deprivation. Additionally, individual variability in neurobehavioral responses to sleep restriction appears to be stable,..
  8. ncbi Sleep duration and mortality: a systematic review and meta-analysis
    Lisa Gallicchio
    The Prevention and Research Center, The Weinberg Center for Women s Health and Medicine, 227 St Paul Place, 6th Floor, Baltimore, MD 21202, USA
    J Sleep Res 18:148-58. 2009
    ..Our findings indicate that both short sleepers and long sleepers are at increased risk of all-cause mortality. Further research using objective measures of sleep duration is needed to fully characterize these associations...
  9. ncbi Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey
    James E Gangwisch
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Hypertension 47:833-9. 2006
    ..Short sleep duration could, therefore, be a significant risk factor for hypertension...
  10. ncbi A prospective study of sleep duration and coronary heart disease in women
    Najib T Ayas
    Division of Pulmonary Medicine, Department of Medicine, Vancouver General Hospital, 2775 Heather St, Vancouver, British Columbia, Canada V5Z 3J5
    Arch Intern Med 163:205-9. 2003
    Long-term sleep deprivation is common in today's society...
  11. ncbi Associations between sleep loss and increased risk of obesity and diabetes
    Kristen L Knutson
    Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    Ann N Y Acad Sci 1129:287-304. 2008
    ..The adverse impact of sleep deprivation on appetite regulation is likely to be driven by increased activity in neuronal populations expressing the ..
  12. ncbi Rest in Drosophila is a sleep-like state
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 25:129-38. 2000
    ..Finally, normal homeostatic regulation depends on the timeless but not the period central clock gene. Understanding the molecular features of Drosophila rest should shed new light on the mechanisms and function of sleep...
  13. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
    ..to treat mood disorders are thought to act by shifting or "resetting" the circadian clock, including total sleep deprivation (TSD) and bright light therapy...
  14. ncbi Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night
    D F Dinges
    Department of Psychiatry, University of Pennyslvania School of Medicine, Philadelphia 19104-6021, USA
    Sleep 20:267-77. 1997
    ..These findings suggest that cumulative nocturnal sleep debt had a dynamic and escalating analog in cumulative daytime sleepiness and that asymptotic or steady-state sleepiness was not achieved in response to sleep restriction...
  15. pmc Sleep restriction for 1 week reduces insulin sensitivity in healthy men
    Orfeu M Buxton
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes 59:2126-33. 2010
    ..This study tests the hypothesis that decreasing nighttime sleep duration reduces insulin sensitivity and assesses the effects of a drug, modafinil, that increases alertness during wakefulness...
  16. ncbi Inadequate sleep as a risk factor for obesity: analyses of the NHANES I
    James E Gangwisch
    Mailman School of Public Health, Department of Epidemiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Sleep 28:1289-96. 2005
    b>Sleep deprivation has been hypothesized to contribute toward obesity by decreasing leptin, increasing ghrelin, and compromising insulin sensitivity...
  17. ncbi Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
    Hans K Meier-Ewert
    Department of Cardiology, Lahey Clinic Medical Center, Burlington, Boston, Massachusetts, USA
    J Am Coll Cardiol 43:678-83. 2004
    ..We sought to investigate the effects of sleep loss on high-sensitivity C-reactive protein (CRP) levels...
  18. ncbi The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, and Centerfor Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Sleep 26:117-26. 2003
    ..reduced without consequences, we conducted a dose-response chronic sleep restriction experiment in which waking neurobehavioral and sleep physiological functions were monitored and compared to those for total sleep deprivation.
  19. ncbi Early-life determinants of overweight and obesity: a review of systematic reviews
    L Monasta
    Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    Obes Rev 11:695-708. 2010
    ..Future research should focus on early-life interventions to confirm the role of protective and risk factors and to tackle the high burden obesity represents for present and future generations...
  20. ncbi Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance
    Jack A De Havas
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School, Singapore
    Neuroimage 59:1745-51. 2012
    b>Sleep deprivation (SD) can alter extrinsic, task-related fMRI signal involved in attention, memory and executive function...
  21. pmc Sleep deprivation during pregnancy and maternal and fetal outcomes: is there a relationship?
    Jen Jen Chang
    Department of Community Health in Epidemiology, Saint Louis University School of Public Health, 3545 Lafayette Ave, Suite 300, St Louis, MO 63104, USA
    Sleep Med Rev 14:107-14. 2010
    ..Prior research has indicated that sleep deprivation is associated with higher levels of pro-inflammatory serum cytokines...
  22. pmc Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies
    Francesco P Cappuccio
    University of Warwick, Warwick Medical School, Clinical Sciences Research Institute, Coventry, UK
    Sleep 33:585-92. 2010
    ..Increasing evidence suggests an association between both short and long duration of habitual sleep with adverse health outcomes...
  23. ncbi Is sleep duration associated with childhood obesity? A systematic review and meta-analysis
    Xiaoli Chen
    Department of International Health, Center for Human Nutrition, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Obesity (Silver Spring) 16:265-74. 2008
  24. ncbi PER3 polymorphism predicts sleep structure and waking performance
    Antoine U Viola
    Surrey Sleep Research Centre, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Curr Biol 17:613-8. 2007
    ..The data show that this polymorphism in PER3 predicts individual differences in the sleep-loss-induced decrement in performance and that this differential susceptibility may be mediated by its effects on sleep homeostasis...
  25. ncbi Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines
    A N Vgontzas
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:2119-26. 2004
    ..Given the potential association of these behavioral and physical alterations with health, well-being, and public safety, the idea that sleep or parts of it are optional should be regarded with caution...
  26. ncbi Effect of reducing interns' work hours on serious medical errors in intensive care units
    Christopher P Landrigan
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 351:1838-48. 2004
    Although sleep deprivation has been shown to impair neurobehavioral performance, few studies have measured its effects on medical errors.
  27. ncbi Fos expression in orexin neurons varies with behavioral state
    I V Estabrooke
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 21:1656-62. 2001
    ..b>Sleep deprivation or treatment with methamphetamine also increased Fos expression in orexin neurons...
  28. pmc Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss
    Michael M Halassa
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 61:213-9. 2009
    ....
  29. pmc Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase
    June C Lo
    Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
    PLoS ONE 7:e45987. 2012
    ....
  30. ncbi The impact of sleep deprivation on decision making: a review
    Y Harrison
    Sleep Research Laboratory, Loughborough University, Leicestershire, United Kingdom
    J Exp Psychol Appl 6:236-49. 2000
    Few sleep deprivation (SD) studies involve realism or high-level decision making, factors relevant to managers, military commanders, and so forth, who are undergoing prolonged work during crises...
  31. pmc Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis
    Valérie Mongrain
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Sleep 33:1147-57. 2010
    ..Because sleep deprivation also induces stress, we here determined the contribution of the corticosterone component of the stress ..
  32. pmc Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine
    L Ian Schmitt
    Department of Neuroscience, Tufts University Medical School, Boston, MA 02111, USA
    J Neurosci 32:4417-25. 2012
    ..that the net extracellular concentration of this transmitter increased in response to normal wakefulness and sleep deprivation. Genetic inhibition of gliotransmission prevented this increase and attenuated the wakefulness-dependent ..
  33. ncbi Age, performance and sleep deprivation
    Pierre Philip
    Clinique du Sommeil, Centre Hospitalier Universitaire Pellegrin, Bordeaux, France
    J Sleep Res 13:105-10. 2004
    ..Ten young (20-25 years old) and 10 older volunteers (52-63 years old) were tested with and without 24 h of sleep deprivation. Without sleep deprivation, RTs were slower in older subjects than in the younger ones...
  34. ncbi Acute sleep deprivation reduces energy expenditure in healthy men
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Am J Clin Nutr 93:1229-36. 2011
    ..Epidemiologic evidence indicates that chronic sleep curtailment increases risk of developing obesity, but the mechanisms behind this relation are largely unknown...
  35. pmc Effects of sleep deprivation on dissociated components of executive functioning
    Adrienne M Tucker
    Sleep and Performance Research Center, Washington State University Spokane, WA 99210 1495, USA
    Sleep 33:47-57. 2010
    We studied the effects of sleep deprivation on executive functions using a task battery which included a modified Sternberg task, a probed recall task, and a phonemic verbal fluency task...
  36. ncbi Gender and age differences in psychomotor vigilance performance under differential sleep pressure conditions
    Katharina Blatter
    Centre for Chronobiology, Psychiatric University Clinics, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    Behav Brain Res 168:312-7. 2006
    ..men and 8 women, 20-31 years) and 16 elderly healthy subjects (8 men and 8 women, 57-74 years) during a 40-h sleep deprivation (SD, high sleep pressure) and a 40-h multiple nap protocol (NAP, low sleep pressure) under dim light and ..
  37. ncbi Neurocognitive consequences of sleep deprivation
    Jeffrey S Durmer
    Program in Sleep Medicine, Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Neurol 25:117-29. 2005
    ..b>Sleep deprivation studies repeatedly show a variable (negative) impact on mood, cognitive performance, and motor function due ..
  38. ncbi Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load
    Bruce S McEwen
    Harold and Margaret Milliken Hatch, Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA mcewenmail rockefeller edu
    Metabolism 55:S20-3. 2006
    Sleep has important homeostatic functions, and sleep deprivation is a stressor that has consequences for the brain, as well as many body systems...
  39. pmc Short sleep duration in middle childhood: risk factors and consequences
    Gillian M Nixon
    Ritchie Centre obr Baby Health Research, Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Sleep 31:71-8. 2008
    ..To measure sleep duration in 7-year-old children; identify the determinants of sleep duration; and assess the association between short sleep duration and obesity, cognitive functioning, and behaviour...
  40. ncbi Reduced sleep in Drosophila Shaker mutants
    Chiara Cirelli
    Department of Psychiatry, 6001 Research Park Blvd, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    Nature 434:1087-92. 2005
    ..mns flies perform normally in a number of tasks, have preserved sleep homeostasis, but are not impaired by sleep deprivation. We then show that mns flies carry a point mutation in a conserved domain of the Shaker gene...
  41. pmc Insufficient sleep undermines dietary efforts to reduce adiposity
    Arlet V Nedeltcheva
    The University of Chicago, Illinois, USA
    Ann Intern Med 153:435-41. 2010
    ..Sleep loss can modify energy intake and expenditure...
  42. ncbi The homeostatic regulation of sleep need is under genetic control
    P Franken
    Biochemistry and Neurophysiology Unit, Department of Psychiatry, University of Geneva, Chene Bourg, Switzerland
    J Neurosci 21:2610-21. 2001
    ..We followed the segregation of the rebound of delta power after sleep deprivation in 25 BXD recombinant inbred strains by quantitative trait loci (QTL) analysis...
  43. ncbi Association of usual sleep duration with hypertension: the Sleep Heart Health Study
    Daniel J Gottlieb
    The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R 304, Boston, MA 02118 2394, USA
    Sleep 29:1009-14. 2006
    ..This study assesses the relationship between usual sleep duration and hypertension in a community-based cohort...
  44. ncbi Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans
    C Cajochen
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Sleep Res Online 2:65-9. 1999
    The effect of sleep deprivation (40 h) on topographic and temporal aspects of electroencephalographic (EEG) activity during sleep was investigated by all night spectral analysis in six young volunteers...
  45. pmc Effects of sleep fragmentation on glucose metabolism in normal subjects
    Katherine A Stamatakis
    Department of Epidemiology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 137:95-101. 2010
    ..The objective of this study was to examine whether experimental sleep fragmentation across all sleep stages would alter glucose metabolism, adrenocortical function, and sympathovagal balance...
  46. ncbi Sleep homeostasis in Drosophila melanogaster
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison 53719, USA
    Sleep 27:628-39. 2004
    ..to determine whether in flies, as in mammals, (1) sleep rebound is dependent on prior time awake; (2) sleep deprivation affects the intensity, in addition to the duration, of sleep rebound; (3) sleep loss impairs vigilance and ..
  47. ncbi Short sleep duration as a possible cause of obesity: critical analysis of the epidemiological evidence
    L S Nielsen
    Institute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen, Denmark
    Obes Rev 12:78-92. 2011
    ..Experimental studies may elucidate mechanisms, but adequate coverage of the entire pathway from sleep curtailment through obesity development is not feasible. Randomized trials are needed to assess the value of targeted interventions...
  48. ncbi Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to sleep deprivation in laboratory rats
    Carol A Everson
    Medical College of Wisconsin, Veterans Affairs Medical Center, Neurology Research 151, 5000 West National Ave, Milwaukee WI 53295, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1054-63. 2005
    The specific systems and mechanisms affected by sleep deprivation that may perpetuate disease processes in humans still are speculative...
  49. ncbi Functional neuroimaging of sleep deprived healthy volunteers and persons with sleep disorders: a brief review
    Lisa Y M Chuah
    Cognitive Neuroscience Lab, Duke NUS Graduate Medical School, Singapore
    Ann Acad Med Singapore 37:689-94. 2008
    ....
  50. ncbi Heart rate variability and endothelial function after sleep deprivation and recovery sleep among male shift and non-shift workers
    Sophie M T Wehrens
    Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK
    Scand J Work Environ Health 38:171-81. 2012
    Endothelial dysfunction and alterations in heart rate variability (HRV) as well as sleep deprivation and shift work have been associated with cardiovascular disease...
  51. pmc Update on energy homeostasis and insufficient sleep
    Plamen D Penev
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Chicago, MC 1027, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 97:1792-801. 2012
    ....
  52. pmc Sleep duration and biomarkers of inflammation
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, University Hospital Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Sleep 32:200-4. 2009
    ..Extremes of sleep duration have been associated with adverse health outcomes. The mechanism is unclear but may be related to increased inflammation. We sought to assess the association between sleep duration and inflammatory biomarkers...
  53. ncbi Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor
    Dag Stenberg
    Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    J Sleep Res 12:283-90. 2003
    b>Sleep deprivation (SD) increases extracellular adenosine levels in the basal forebrain, and pharmacological manipulations that increase extracellular adenosine in the same area promote sleep...
  54. ncbi Gender differences in brain regional homogeneity of healthy subjects after normal sleep and after sleep deprivation: a resting-state fMRI study
    Xi Jian Dai
    Department of Radiology, The First Affiliated Hospital, Nanchang University, Jiangxi 330006, China
    Sleep Med 13:720-7. 2012
    ..the gender differences of brain regional homogeneity (ReHo) in healthy subjects during the resting-state, after normal sleep, and after sleep deprivation (SD) using functional magnetic resonance imaging (fMRI) and the ReHo method.
  55. ncbi Extended work shifts and the risk of motor vehicle crashes among interns
    Laura K Barger
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 352:125-34. 2005
    ..Long work hours and work shifts of an extended duration (> or =24 hours) remain a hallmark of medical education in the United States. Yet their effect on health and safety has not been evaluated with the use of validated measures...
  56. ncbi Quantitative physiologically based modeling of subjective fatigue during sleep deprivation
    B D Fulcher
    School of Physics, University of Sydney, New South Wales 2006, Australia
    J Theor Biol 264:407-19. 2010
    ..of the sleep-wake switch is used to predict variations in subjective fatigue-related measures during total sleep deprivation. The model includes the mutual inhibition of the sleep-active neurons in the hypothalamic ventrolateral ..
  57. pmc Disturbed glucoregulatory response to food intake after moderate sleep restriction
    Sebastian M Schmid
    Department of Internal Medicine I, University of Luebeck, Luebeck, Germany
    Sleep 34:371-7. 2011
    ....
  58. pmc Antidepressant effects of selective slow wave sleep deprivation in major depression: a high-density EEG investigation
    ERIC C LANDSNESS
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    J Psychiatr Res 45:1019-26. 2011
    b>Sleep deprivation can acutely reverse depressive symptoms in some patients with major depression...
  59. ncbi Sustained attention performance during sleep deprivation: evidence of state instability
    S M Doran
    Division of Sleep and Chronobiology, Department of Psychiatry, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 1013 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    Arch Ital Biol 139:253-67. 2001
    Nathaniel Kleitman was the first to observe that sleep deprivation in humans did not eliminate the ability to perform neurobehavioral functions, but it did make it difficult to maintain stable performance for more than a few minutes...
  60. ncbi The effect of sleep fragmentation on daytime function
    Edward J Stepanski
    Sleep Disorder Service and Research Center, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Sleep 25:268-76. 2002
    ..Ideally, clarification of these measurement issues will lead to an improved understanding of sleep structure and the mechanism through which sleep fragmentation impacts daytime function...
  61. pmc Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism
    Erin C Hanlon
    Sleep, Metabolism, and Health Center, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 108:15609-16. 2011
    ..A better understanding of the adverse effects of sleep restriction on the CNS control of hunger and appetite may have important implications for public health...
  62. pmc Healthy older adults better tolerate sleep deprivation than young adults
    Jeanne F Duffy
    Brigham and Women s Hospital General Clinical Research Center, Boston, Massachusetts, USA
    J Am Geriatr Soc 57:1245-51. 2009
    ..To determine whether healthy aging is associated with increased sleepiness and whether healthy older adults experience more sleepiness when acutely sleep deprived...
  63. ncbi Small platform sleep deprivation selectively increases the average duration of rapid eye movement sleep episodes during sleep rebound
    Tamas Kitka
    Semmelweis University, Department of Pharmacodynamics, Nagyvarad ter 4, Budapest 1089, Hungary
    Behav Brain Res 205:482-7. 2009
    ..that the increased mean duration of REMS episodes is a selective marker for the rebound caused by small platform sleep deprivation, while other changes in sleep architecture may be the consequence of stress and also some sleep deficit.
  64. ncbi Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans
    Valérie Bachmann
    Institute of Pharmacology and Toxicology University of Zurich, Zurich, Switzerland
    Cereb Cortex 22:962-70. 2012
    ..whether it modulates electroencephalogram (EEG), behavioral, subjective, and biochemical responses to sleep deprivation. Attention, learning, memory, and executive functioning were quantified in healthy adults...
  65. pmc Chronic sleep deprivation and seasonality: implications for the obesity epidemic
    G Cizza
    Section on Neuroendocrinology of Obesity, NIDDK, Bethesda, MD, USA
    J Endocrinol Invest 34:793-800. 2011
    ..Several studies have reported an association between chronic sleep deprivation and long-term weight gain. Increased energy intake due to sleep loss has been listed as the main mechanism...
  66. ncbi Is sleep duration related to obesity? A critical review of the epidemiological evidence
    Nathaniel S Marshall
    Sleep and Circadian Group, Woolcock Institute of Medical Research, University of Sydney, Australia
    Sleep Med Rev 12:289-98. 2008
    ....
  67. ncbi Sleep deprivation affects thermal pain thresholds but not somatosensory thresholds in healthy volunteers
    Bernd Kundermann
    Department of Psychiatry and Psychotherapy, Philipps University Marburg, Rudolf Bultmann Str 8, Marburg D 35033, Germany
    Psychosom Med 66:932-7. 2004
    Sleep disturbances have been thought to augment pain. Sleep deprivation has been proven to produce hyperalgesic effects...
  68. ncbi Less effective executive functioning after one night's sleep deprivation
    Jens P Nilsson
    National Institute for Psychosocial Medicine, Stockholm, Sweden
    J Sleep Res 14:1-6. 2005
    The prefrontal cortex (PFC) is affected negatively by sleep deprivation (SD) and executive functioning is largely dependent on activity in the PFC...
  69. ncbi Fatigue, sleep restriction and driving performance
    Pierre Philip
    Clinique du Sommeil, CHU Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Accid Anal Prev 37:473-8. 2005
    ..Sleepiness combined with fatigue significantly affected RT. Road safety campaigns should encourage drivers to avoid driving after sleep restriction, even on relatively short trips especially if they feel sleepy...
  70. pmc Neurocognitive consequences of sleep deprivation
    Namni Goel
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Semin Neurol 29:320-39. 2009
    b>Sleep deprivation is associated with considerable social, financial, and health-related costs, in large measure because it produces impaired cognitive performance due to increasing sleep propensity and instability of waking ..
  71. ncbi Stress response genes protect against lethal effects of sleep deprivation in Drosophila
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, California 92121, USA
    Nature 417:287-91. 2002
    ..cyc(01) mutants showed a disproportionately large sleep rebound and died after 10 hours of sleep deprivation, although they were more resistant than other clock mutants to various stressors...
  72. pmc Sleep loss activates cellular inflammatory signaling
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, CA 90095 7076, USA
    Biol Psychiatry 64:538-40. 2008
    ..This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade...
  73. ncbi The effects of sleep deprivation on pain inhibition and spontaneous pain in women
    Michael T Smith
    Behavioral Sleep Medicine Program, Johns Hopkins Bayview, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA
    Sleep 30:494-505. 2007
    ..RSO subjects were yoked to FA on total sleep time (TST), receiving partial sleep deprivation by delayed bedtime...
  74. ncbi Evolution of sleep quantity, sleep deprivation, mood disturbances, empathy, and burnout among interns
    Ilene M Rosen
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Acad Med 81:82-5. 2006
    To explore the relationships between sleep deprivation and the evolution of mood disturbances, empathy, and burnout among a cohort of interns.
  75. ncbi Effects of sleep deprivation on cognition
    William D S Killgore
    Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Prog Brain Res 185:105-29. 2010
    b>Sleep deprivation is commonplace in modern society, but its far-reaching effects on cognitive performance are only beginning to be understood from a scientific perspective...
  76. ncbi Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7057, USA
    Arch Intern Med 166:1756-62. 2006
    ..The effects of sleep loss on the cellular and genomic mechanisms that contribute to inflammatory cytokine activity are not known...
  77. ncbi Functional imaging of working memory after 24 hr of total sleep deprivation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, SingHealth Research Laboratories, Singapore 169611, Singapore
    J Neurosci 24:4560-7. 2004
    The neurobehavioral effects of 24 hr of total sleep deprivation (SD) on working memory in young healthy adults was studied using functional magnetic resonance imaging...
  78. ncbi Trends in self-reported sleep duration and insomnia-related symptoms in Finland from 1972 to 2005: a comparative review and re-analysis of Finnish population samples
    Erkki Kronholm
    The National Public Health Institute, Turku, Finland
    J Sleep Res 17:54-62. 2008
    ..In conclusion, the Finnish data during the past 33 years indicate a general decrease in self-reported sleep duration of about 18 min and an increase of sleep complaints, especially among the employed middle-aged population...
  79. ncbi The REM sleep-memory consolidation hypothesis
    J M Siegel
    Center for Sleep Research, Department of Veterans Affairs, Greater Los Angeles Healthcare System VA GLAHCS, North Hills, CA 91343, USA
    Science 294:1058-63. 2001
    ..Although sleep is clearly important for optimum acquisition and performance of learned tasks, a major role in memory consolidation is unproven...
  80. ncbi Brief sleep after learning keeps emotional memories alive for years
    Ullrich Wagner
    Department of Neuroendocrinology, Medical University of Lubeck, Lubeck, Germany
    Biol Psychiatry 60:788-90. 2006
    ....
  81. ncbi Sleep duration as a risk factor for incident type 2 diabetes in a multiethnic cohort
    Deborah A Beihl
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29205, USA
    Ann Epidemiol 19:351-7. 2009
    ..We evaluated the association between sleep duration and type 2 diabetes in a multiethnic cohort, considering insulin sensitivity (S(I)) and secretion (acute insulin response [AIR]), two important diabetes risk factors...
  82. ncbi Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system
    C Cirelli
    The Neurosciences Institute, San Diego, California 92121, USA
    J Neurosci 20:9187-94. 2000
    ..These molecular results complement behavioral evidence and provide a mechanism for the impairment of long-term memory acquisition during sleep...
  83. ncbi Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation
    B Bodosi
    Department Physiology, University of Szeged, A Szent Györgyi Medical Center, Hungary
    Am J Physiol Regul Integr Comp Physiol 287:R1071-9. 2004
    ..rhythms, in rats with feeding restricted to the 12-h light period (RF), and in rats subjected to 5-h of sleep deprivation (SD) at the beginning of the light cycle...
  84. ncbi The neural basis of the psychomotor vigilance task
    Sean P A Drummond
    University of California San Diego, Department of Psychiatry, 92161, USA
    Sleep 28:1059-68. 2005
    To identify brain regions underlying the fastest and slowest reaction times on the Psychomotor Vigilance task (PVT) under well-rested conditions, as well as brain regions related to particularly poor performance after sleep deprivation.
  85. ncbi The human emotional brain without sleep--a prefrontal amygdala disconnect
    Seung Schik Yoo
    Curr Biol 17:R877-8. 2007
  86. ncbi Lapsing during sleep deprivation is associated with distributed changes in brain activation
    Michael W L Chee
    Cognitive Neuroscience Laboratory, Duke National University of Singapore Graduate Medical School, Singapore
    J Neurosci 28:5519-28. 2008
    ..they can occur even after a normal night's sleep, they are longer in duration and more frequent after sleep deprivation (SD)...
  87. ncbi Acute partial sleep deprivation increases food intake in healthy men
    Laurent Brondel
    Centre Européen des Sciences du Goût, Dijon, France
    Am J Clin Nutr 91:1550-9. 2010
    Acute partial sleep deprivation increases plasma concentrations of ghrelin and decreases those of leptin.
  88. ncbi A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects
    Esther Donga
    Department of Endocrinology and Metabolic Diseases, C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:2963-8. 2010
    ..Subsequent nights with partial sleep restriction result in impaired glucose tolerance, but the effects on insulin sensitivity have not been characterized...
  89. ncbi Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder
    Joseph C Wu
    Department of Psychiatry and Human Behavior, University of California at Irvine School of Medicine, Room 109, Irvine Hall, Irvine, CA 92697 3960, USA
    Biol Psychiatry 66:298-301. 2009
    ..The most widely documented rapid-onset antidepressant therapy is sleep deprivation (SD), which acts within 24-48 hours in 40%-60% of depressed patients...
  90. ncbi Sleep, learning, and dreams: off-line memory reprocessing
    R Stickgold
    Laboratory of Neurophysiology and Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Science 294:1052-7. 2001
    ....
  91. ncbi Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight
    W T Shearer
    Baylor College of Medicine, Houston, Texas, USA
    J Allergy Clin Immunol 107:165-70. 2001
    ..proteins soluble TNF-alpha receptor (sTNF-alpha R) I and IL-6, in human subjects undergoing 2 types of sleep deprivation during environmental confinement with performance demands...
  92. pmc Leptin and hunger levels in young healthy adults after one night of sleep loss
    Slobodanka Pejovic
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    J Sleep Res 19:552-8. 2010
    ..changes associated with sleep loss, 21 young healthy individuals (10 men, 11 women) participated in a 7-day sleep deprivation experiment (four consecutive nights followed by one night of sleep loss and two recovery nights)...
  93. ncbi Dopamine is a regulator of arousal in the fruit fly
    Kazuhiko Kume
    Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    J Neurosci 25:7377-84. 2005
    ..These results provide direct evidence that dopaminergic signaling has a critical function in the regulation of insect arousal...
  94. pmc Sleep deprivation and interference by emotional distracters
    Lisa Y M Chuah
    Cognitive Neuroscience Laboratory, Duke NUS Graduate Medical School Singapore, Singapore
    Sleep 33:1305-13. 2010
    We determined if sleep deprivation would amplify the effect of negative emotional distracters on working memory.
  95. pmc P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1
    Lena Backlund
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e43057. 2012
    ..We hypothesized that the P2RX7 gene would be affected by sleep deprivation and be implicated in rapid cycling.
  96. ncbi Cardiovascular effects of partial sleep deprivation in healthy volunteers
    Josilene L Dettoni
    Sleep Laboratory of Pulmonary Division of Heart Institute, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil
    J Appl Physiol (1985) 113:232-6. 2012
    b>Sleep deprivation is common in Western societies and is associated with increased cardiovascular morbidity and mortality in epidemiological studies...
  97. pmc Sleep loss exacerbates fatigue, depression, and pain in rheumatoid arthritis
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, Los Angeles, California 90095 7076, USA
    Sleep 35:537-43. 2012
    ..This study evaluated the effect of sleep loss during part of the night on daytime mood symptoms and pain perceptions in patients with rheumatoid arthritis in comparison with control subjects...
  98. pmc Sleep duration in the United States: a cross-sectional population-based study
    Patrick M Krueger
    School of Public Health, University of Texas, Houston, TX 77030, USA
    Am J Epidemiol 169:1052-63. 2009
    ..The authors identify numerous risk factors for long and short sleep; many of those variables are potential confounders of the relation between sleep hours and other health outcomes...
  99. ncbi Inducible and neuronal nitric oxide synthases (NOS) have complementary roles in recovery sleep induction
    A V Kalinchuk
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki 00014, Finland
    Eur J Neurosci 24:1443-56. 2006
    ..We have previously shown that nitric oxide (NO) generation increases in the basal forebrain (BF) during sleep deprivation (SD)...
  100. pmc Control and function of the homeostatic sleep response by adenosine A1 receptors
    Theresa E Bjorness
    Department of Psychiatry, University of Texas Southwestern, Dallas, Texas 75390, USA
    J Neurosci 29:1267-76. 2009
    ..Thus, AdoA(1)R activation is needed for normal rebound SWA, and when the SWA rebound is reduced, there is a failure to maintain working memory function, suggesting a functional role for SWA homeostasis...
  101. ncbi Sleep deprivation is associated with lower diet quality indices and higher rate of general and central obesity among young female students in Iran
    Fahimeh Haghighatdoost
    Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
    Nutrition 28:1146-50. 2012
    ..However, little is known about the relationship between sleep duration and the quality of diets. Therefore, we aimed to compare the diet quality indices and anthropometric measures between short and longer sleepers...

Research Grants78

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..Studies in animals and humans suggest that sleep deprivation leads to changes in hormones and increased sympathetic nervous system (SNS) function amongst other effects...
  3. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    ..Medical targets of interest are sleep/circadian disorders, sleep apnea, obesity/diabetes, REM/NREM sleep deprivation, and stress, among others...
  4. The Role of Circadian Periodicity in Human Cardiovascular Disease and Diabetes
    John P Forman; Fiscal Year: 2013
    ..there is an interplay between these circadian elements and lifestyle-induced circadian disruption (like sleep deprivation and snoring)...
  5. Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2013
    ..in sleep- wake regulation by analyzing the sleep architecture during normal sleep, induced sleep, and after sleep deprivation. In conclusion, zebrafish offers a unique situation as a transparent vertebrate to perform non-invasive ..
  6. Basal Forebrain Cellular Mechanisms of Cortical Activation
    Robert W McCarley; Fiscal Year: 2013
    ..to gain a precise determination of local gamma oscillations in three different cortical regions affected by sleep deprivation and exhibiting abnormalities in schizophrenia...
  7. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
    ..both tinnitus and activity in the subcallosal area (including the NAc) are modulated by stress, arousal, and sleep deprivation. The aims of the proposed research are 1) to provide direct evidence for reorganization of tonotopic maps in ..
  8. Weight gain, type 2 diabetes, and factors that affect neuroendocrine function
    EDWARD ANTONIO RUIZ-NARVAEZ; Fiscal Year: 2013
    ..and with a low birth weight, and more likely to experience violence victimization, racism, depression, and sleep deprivation. Because the FTO gene, the gene most strongly associated with fat mass and obesity in AA as well as European ..
  9. Neuroanatomical and functional outcomes of pediatric obstructive sleep apnea
    Robert Joseph Thomas; Fiscal Year: 2012
    ..sleep fragmentation causes impaired hippocampal long-term potentiation of memory and neurogenesis, while sleep deprivation further leads to cellular stress...
  10. Effects of sleep deprivation and high fat diet on human CYP7A1 circadian rhythm
    JESSICA MARIE FERRELL; Fiscal Year: 2013
    ..the interactions of circadian rhythms and hepatic metabolism in a CYP7A1 humanized mouse model undergoing sleep deprivation and high-fat feeding to elucidate the mechanisms by which circadian misregulation contributes to Type II ..
  11. Crosslink augmentation to resist snoring and obstructive sleep apnea syndrome
    Thomas P Hedman; Fiscal Year: 2013
    ....
  12. Melanin-Concentrating Hormone: Ancestral Role in Feeding & Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2010
    ..in sleep- wake regulation by analyzing the sleep architecture during normal sleep, induced sleep, and after sleep deprivation. In conclusion, zebrafish offers a unique situation as a transparent vertebrate to perform non-invasive ..
  13. Time-of-Day-Dependent Feeding Influences Myocardial Function
    MARTIN ELLIOT YOUNG; Fiscal Year: 2012
    Common environmental factors within Western society, such as excess caloric intake, physical inactivity, and sleep deprivation are strongly associated with the development of modern day epidemics, including obesity, type 2 diabetes ..
  14. Prediction of Physiological Events in People with Sleep Disordered Breathing
    Jonathan A Waxman; Fiscal Year: 2011
    ..insight into the underlying pathophysiology of SDB and EDS, and will investigate sex differences in OSA and sleep deprivation. OSA is a major public health problem whose effects on society are comparable to those of smoking...
  15. Sleep promotion in zebrafish by hypocretin neuronal networks
    Philippe Mourrain; Fiscal Year: 2012
    ..early gene (c- fos) expression analysis of adult zebrafish brains during the night and the day, after sleep deprivation and after hypnotic drug treatments. 15% of the population suffers of sleep disorders...
  16. Impact of Corticotropin Releasing Factor (CRF) on Sleep Regulation
    Ronald Szymusiak; Fiscal Year: 2013
    ..that neuronal discharge in the MnPN and VLPO is tightly coupled to changing homeostatic sleep need during sleep deprivation (SD) and recovery sleep (RS)...
  17. Interleukin-1: A Promoter of Slow Wave Sleep
    JAMES MARTIN KRUEGER; Fiscal Year: 2013
    ..Although its function remains unknown preliminary data show that sleep deprivation enhances its cortical expression...
  18. Quantification of the State-Dependent Inputs to Hypoglossal Motoneurons
    VICTOR BORISOVICH FENIK; Fiscal Year: 2010
    ..in hemoglobin oxygen saturation, accumulation of CO2, and frequent awakenings which results in chronic sleep deprivation and fragmentation. OSA patients suffer from excessive daytime sleepiness and diminished quality of life...
  19. Upper airway control during disrupted and misaligned sleep
    LESZEK K KUBIN; Fiscal Year: 2013
    ..rats, rats with circadian regulation of sleep abolished by housing in constant light, and rats subjected to sleep deprivation. We will also determine the time course of lingual EMG changes during state transitions (sleep entries and ..
  20. CRCNS: Multiresolution Modeling of Human Thalamocortical Upstates and Downstates
    Eric Halgren; Fiscal Year: 2013
    ..Sleep disorders - notably sleep apnea, sleep deprivation and sleepiness - affect 70 million Americans, resulting in $16 billion in annual healthcare expenses and $50 ..
  21. Feasibility of Measuring Sleep in a Critical Care Environment
    Margaret A Pisani; Fiscal Year: 2010
    ..The knowledge of the importance of sleep and the adverse effects of sleep deprivation has grown in an exponential manner over the last few years. Although approximately 5...
  22. Comparison of two guided self-help treatments for binge eating disorder
    Athena Robinson; Fiscal Year: 2013
    ..g., hunger, sleep deprivation), interpersonal conflict, and, when possible, unpleasant external events...
  23. The Impact of Sleep Deprivation on Affect Regulation in Young Adults
    Peter L Franzen; Fiscal Year: 2011
    Project Summary: Sleep deprivation (SD) impairs attention, executive function, and affect regulation...
  24. Purinergic Mechanisms in Homeostatic Sleep Control
    Radhika Basheer; Fiscal Year: 2013
    ..While there is ample evidence demonstrating a sleep deprivation (SD)-induced [AD]ex increase in BF, the mechanisms for this regional and localized increase is yet unknown...
  25. Investigating Genetics of Human Natural Short Sleepers
    Ying Hui Fu; Fiscal Year: 2013
    ..b>Sleep deprivation increases an individual's risk of cancer, metabolic syndrome, psychiatric, and other disorders...
  26. Dynamics and Homeostasis of Glycinergic Synapses
    Dawnis M Chow; Fiscal Year: 2013
    ..the dynamics of dendra-tagged synaptic proteins will be measured (as in Aim 1) during the day and during sleep deprivation at night...
  27. Multi-Center Trial of Limiting PGY2&3 Resident Work Hours on Patient Safety-CCC
    CHRISTOPHER PAUL LANDRIGAN; Fiscal Year: 2013
    ..b>Sleep deprivation and circadian misalignment resulting from resident physicians'recurrent extended work shifts may be an ..
  28. Genetic Approaches to Sleep/Wake and Response to Sleep Loss in Mice
    ALLAN IAN PACK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sleep deprivation is common and increasing in prevalence in the American population. Loss of sleep has a number of adverse consequences...
  29. 2012 Pineal Cell Biology Gordon Research ConferenceLinks to circadian clocks, sl
    Vincent M Cassone; Fiscal Year: 2011
    ..Recent research has demonstrated clear links between circadian clocks and metabolism, between sleep deprivation and metabolic disorders and between circadian rhythms, light and sleep...
  30. Unobtrusive measurement of sleep disordered breathing in the home
    Tamara Hayes; Fiscal Year: 2012
    ..Sleep disorders and sleep deprivation are significant public health problems. The U.S...
  31. Preoptic/hypothalamic mechanisms of sleep-wake regulation
    NOOR ALAM; Fiscal Year: 2013
    ..sleep and further accumulates during sleep deprivation, b) whether focal blockade of HCRT signaling in the PF-LHA during sleep deprivation attenuates production of ..
  32. Mentoring Research in the Physiology of Sleep Disordered Breathing
    INDU A AYAPPA; Fiscal Year: 2013
    ..after controlled suboptimal CPAP (a standardized dose of SDB) and the level of EDS after 24 hours of sleep deprivation. The hypothesis is that susceptibility to these two different forms of sleep disruption is correlated and ..
  33. RAPIDLY-ACTING TREATMENTS FOR TREATMENT-RESISTANT DEPRESSION (RAPID)
    Maurizio Fava; Fiscal Year: 2011
    ..a series of studies has demonstrated the ability of novel approaches [unreadable] including ketamine and sleep deprivation therapy [unreadable] to provide significant amelioration of symptoms within a few hours...
  34. Effects of Sleep Deprivation on Infection Induced Organ Failure
    Leigh A Callahan; Fiscal Year: 2013
    ..Importantly, sleep deprivation in these patients may have adverse consequences...
  35. Optogenetic dissection of basal forebrain neurons involved in sleep homeostasis
    Radhika Basheer; Fiscal Year: 2013
    ..of homeostatic sleep regulation are an important aspect of sleep research given the relevance of sleep deprivation (SD) to human health, well-being, and cognitive performance...
  36. SYNAPTIC BASIS OF SLEEP CYCLE CONTROL
    Robert W McCarley; Fiscal Year: 2013
    ..mediating the homeostatic sleep drive (HSD), the drive that mediates the sleepiness following sleep loss or sleep deprivation (SD)...
  37. Sleep Length and Circadian Regulation in Humans
    HELEN JULIA BURGESS; Fiscal Year: 2012
    ..First, short sleep episodes are associated with partial sleep deprivation. Second, as humans sleep with their eyes closed and are usually exposed to light when awake, short sleep ..
  38. The Effects of Sleep Deprivation on Drug Craving and Cue-Reactivity
    George H Trksak; Fiscal Year: 2012
    ..help the candidate implement the skills outlined in the training plan and proposes to examine the effects of sleep deprivation on cue-reactivity and subjective drug craving by collecting electroencephalogram measures of event-related ..
  39. Sleep deprivation and energy balance
    Virend K Somers; Fiscal Year: 2010
    ..Low grade chronic sleep deprivation may constitute an important and potentially correctable behavioral factor in the alarming increase in ..
  40. The Role of Gliotransmission in Sleep Homeostasis
    Tamara Blutstein; Fiscal Year: 2013
    ..for the accumulation of sleep pressure and contributes to the impairment of working memory following sleep deprivation in an A1R dependent manner...
  41. Aging Systems in Geriatrics: the Male Gonadal Axis
    Johannes D Veldhuis; Fiscal Year: 2013
    ..Unraveling the bases of androgen depletion in the aging male should spark new preventive strategies to obviate failure of anabolic drive, and thus preserve quality of life and function in older individuals. ..
  42. Sleep Restriction and Augmented Vascular Risk in Prehypertension
    Virend K Somers; Fiscal Year: 2012
    ..b>Sleep deprivation may be one of the commonest preventable cardiovascular risk factors...
  43. Sleep Homeostasis, Plasticity and Memory
    Ravi Allada; Fiscal Year: 2013
    ..In addition, we will assess the effects of sleep deprivation on MB-dependent learning and memory and MB synapses...
  44. Latent Structure of Sluggish Cognitive Tempo and ADHD Symptoms
    ROBERT KEITH MCBURNETT; Fiscal Year: 2010
    ..limitation is that SCT items are non-specific and may be related to a range of transitory states (fatigue, sleep deprivation, etc.) and other psychopathological conditions...
  45. Molecular and anatomical basis of sleep regulation by SLEEPLESS
    William J Joiner; Fiscal Year: 2013
    ..the novel gene sleepless (sss) that is required for both baseline and homeostatic recovery sleep following sleep deprivation. In sss mutants, we found that levels of the sleep-regulating K channel, Shaker (Sh), are reduced, leading ..
  46. Biomarker for Sleep Loss: A Proteomic Determination
    NIRINJINI N NAIDOO; Fiscal Year: 2010
    ..volunteers, who had blood samples taken every 4 hours during a normal day, as well as during progressive sleep deprivation, and during recovery sleep...
  47. Glial dependent modulation of depressive like behaviors
    Philip G Haydon; Fiscal Year: 2013
    ..A total night of sleep deprivation has immediate antidepressive actions in the clinical population, although the signaling pathway is unknown...
  48. Sleep Function and Synaptic Homeostasis: Linking Neurobiology and Mental Health
    Giulio Tononi; Fiscal Year: 2010
    ..to evaluate a predicted relationship between preserved slow wave homeostasis and therapeutic response to sleep deprivation. If the hypothesis survives these combined tests, it will provide a scientific explanation of why we need to ..
  49. Neural consequences of sleep loss and sleep physiology on the human reward system
    STEPHANIE MORGAN GREER; Fiscal Year: 2013
    ..One circumstance increasingly related to altered dopaminergic brain reward sensitivity is the state of sleep deprivation. Sleep loss can trigger amplified reactivity in dopaminergic networks in response to pleasurable experiences,..
  50. Intrinsic Circadian Period: Development Delayed Phase and Genetic Associations
    Mary A Carskadon; Fiscal Year: 2012
    ..This research project will help explain a major change in teens'sleeping behavior which often leads to sleep deprivation and mood problems by looking at how the body's biological sleep regulation systems change during ..
  51. Automated sleep detection and deprivation system for fruit flies
    David A Johnson; Fiscal Year: 2012
    ..Control of individual fly sleep deprivation and real-time visualization of data will be available though a web-based control system...
  52. Cellular and Molecular Mechanisms of REM Sleep
    Subimal Datta; Fiscal Year: 2013
    ..Test the hypothesis that during selective REM sleep deprivation, increased slow-wave sleep and increased expression of BDNF in the CCC-PPT are critical for the development ..
  53. Regulation of Nucleus Accumbens Neurons by Sleep Deprivation
    Yanhua H Huang; Fiscal Year: 2013
    ..The proposed research attempts to characterize how sleep deprivation (SD) regulates both excitatory and inhibitory synapses as well as the membrane properties of neurons within ..
  54. Role of Shaker Channel Function in the Regulation of Sleep in Drosophila
    Terry Dean; Fiscal Year: 2011
    ..RELEVANCE: The majority of Americans do not sleep for the recommended "8 hours a night"[9], resulting in sleep deprivation that incurs an estimated ~$15-75 billion per year strain[10-11] on the US economy and is linked to several ..
  55. Regulation of Nucleus Accumbens Neurons by Sleep Deprivation
    Yanhua H Huang; Fiscal Year: 2012
    ..The proposed research attempts to characterize how sleep deprivation (SD) regulates both excitatory and inhibitory synapses as well as the membrane properties of neurons within ..
  56. Low-Dose Methylphenidate and the Prefrontal Cortex
    Craig W Berridge; Fiscal Year: 2013
    ..e. normal aging, sleep deprivation)...
  57. Sleep and Child Developmental Outcomes: Physiological and Contextual Influences
    MONA M EL-SHEIKH; Fiscal Year: 2012
    b>Sleep deprivation in American children is a matter of national concern. Estimates of children with sleep disturbances range from 20% to 40%...
  58. Sleep Depression, and Psychosocial Risk Factors in Caregivers
    Lisa J Meltzer; Fiscal Year: 2012
    ..intervention studies, the use of actigraphy as an objective measure of sleep, and specialized training in sleep deprivation, sleep and depression, and ethical issues related to research with families of children with chronic ..
  59. Metabolic and Cognitive Consequences of Sleep Loss
    Kenneth P Wright; Fiscal Year: 2013
    ..This research effort is responsive to PA-10-152 by assessing effects of sleep deprivation on macronutrient consumption and effects of dietary composition on physiological responses to sleep loss...
  60. Neural consequences of sleep loss and sleep recovery on the human reward system
    Matthew P Walker; Fiscal Year: 2013
    ..One circumstance increasingly related to altered dopaminergic brain reward sensitivity is the state of sleep deprivation. Sleep loss can trigger amplified reactivity in dopaminergic networks in response to pleasurable experiences,..
  61. Brain Plasticity and Local Sleep Homeostasis: An Electrophysiological Perspective
    ERIC C LANDSNESS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): We spend a third of our life asleep, and even partial sleep deprivation has serious consequences on cognition, mood, and health, suggesting that sleep must serve some fundamental functions...
  62. Sleep Patterns and Depression in Mothers and Fathers of Twins
    ELIZABETH DAMATO; Fiscal Year: 2007
    ..have continued to rise over the last 25 years, increasing the number of parents at high risk for partial sleep deprivation, also known as sleep restriction...
  63. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    ..Obstructive sleep apnea (OSA) may exacerbate seizures via sleep fragmentation, sleep deprivation, or other pathophysiological processes that have not yet been determined...
  64. A Rodent Model of TBI Suffered During Sustained Combat Operations
    RONALD RIECHERS; Fiscal Year: 2009
    ..Combat operations require high level of sustained arousal as well as prolonged periods of sleep deprivation. The impact of these factors on TBI has not been studied...
  65. Sleep Disorders Management, Health and Safety in Police
    CHARLES CZEISLER; Fiscal Year: 2006
    ..Our research group has conducted numerous studies of sleep deprivation and interventions to reduce the adverse effects of sleep deprivation on safety, health, and performance of ..
  66. Development of Automated Noninvasive DiskTreadmills for Sleep Deprivation in Mice
    Jidong Fang; Fiscal Year: 2007
    ..human sleep loss results from chronic sleep restriction (CSR), most animal studies focus on acute and total sleep deprivation. Technical difficulties in creating CSR animal models have long hindered efforts to better understand the ..
  67. SLEEP MEMORY: A MOLECULAR AND GENETIC ANALYSIS
    EDWIN ABEL; Fiscal Year: 2002
    ..There are striking parallels between the effects of sleep deprivation and the effects of pharmacological manipulation of the PKA signaling pathway on the consolidation of memory...
  68. NEUROCHEMICAL BASIS OF SLEEP HOMEOSTASIS
    William Dement; Fiscal Year: 2001
    ..terms of its generality, involvement of the basal forebrain, DA receptor subtypes involved, interaction with sleep deprivation, and interaction with adenosinergic mechanisms that also modulate sleep-wakefulness...
  69. FATTY ACID AND PEPTIDE AMIDATION--A SHARED MECHANSIM
    Gregory Mueller; Fiscal Year: 2003
    ..Oleamide accumulates in cerebral spinal fluid during sleep deprivation and induces profound motor quiescence and a sleep-like state upon administration...
  70. NEURAL GENE EXPRESSION IN SLEEP DEPRIVATION AND RECOVERY
    Thomas S Kilduff; Fiscal Year: 2010
    ..nNos) within which the transcription factor Fos is expressed specifically during recovery sleep (RS) after sleep deprivation (SD)...
  71. Impact of resident work hour rules on errors and quality
    Kevin Volpp; Fiscal Year: 2007
    ..By reducing sleep deprivation, the rules will likely have beneficial effects on patient safety and quality of care, but worsened ..
  72. BIOSYNTHESIS OF OLEAMIDE AND OTHER FATTY ACID AMIDES
    DAVID MERKLER; Fiscal Year: 1999
    ..Oleamide was originally discovered as an agent that accumulates in the cerebral spinal fluid of cats during sleep deprivation. Subsequently, it was shown to induce sleep/sedation following either central or peripheral administration...
  73. The Roles of Neuropeptide S System in the Regulation of Sleep and Wakefulness
    Yanling Xu; Fiscal Year: 2007
    ..To determine NPS peptide, precursor and receptor mRNA concentrations during the light/dark cycle and after sleep deprivation. We will monitor the expressions of NPS peptide, NPS precursor and receptor mRNA contents at different ..
  74. ONTOGENY OF DEPRESSIVE SUBSTRATES
    Pingfu Feng; Fiscal Year: 2001
    ..investigator has recently developed the first successful technique to produce long-term, instrumental REM sleep deprivation (IRSD)...
  75. CHRONOBIOLOGY OF PREMENSTRUAL SYNDROME
    Barbara Parry; Fiscal Year: 1993
    ..In pilot studies, we have found that phototherapy and sleep deprivation have marked therapeutic effects in PMS patients...
  76. MOLECULAR REGULATION OF ADENOSINE IN RELATION TO SLEEP
    Miroslaw Mackiewicz; Fiscal Year: 2000
    ..Extracellular levels of adenosine change across the sleep/wake cycle. Short-term sleep deprivation increases adenosine in an area of the brain known to be critical for sleep (basal forebrain)...
  77. Sleep Mechanisms in Children: Role of Metabolism
    Gabriel Haddad; Fiscal Year: 2002
    ..understanding of the mechanisms that induce or maintain sleep or those mechanisms that are activated with sleep deprivation. One of the potentially important areas that have started to develop is the role of brain metabolism in ..