sleep arousal disorders

Summary

Summary: Sleep disorders characterized by impaired arousal from the deeper stages of sleep (generally stage III or IV sleep).

Top Publications

  1. ncbi Nonrandom variability of respiration during sleep in healthy humans
    Sven Rostig
    SP Pneumologie, Philipps Universitat Marburg, Schlafmedizinisches Labor, Marburg, Germany
    Sleep 28:411-7. 2005
  2. ncbi Atypical presentation of NREM arousal parasomnia with repetitive episodes
    N N Trajanovic
    Sleep and Alertness Clinic, University Health Network, Toronto, ON, Canada
    Eur J Neurol 14:947-50. 2007
  3. pmc Adult obstructive sleep apnea: pathophysiology and diagnosis
    Susheel P Patil
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, MD 21224, USA
    Chest 132:325-37. 2007
  4. ncbi From epidemiology to physiology and pathology: apnea and arousal deficient theories in sudden infant death syndrome (SIDS)--with particular reference to hypoxic brainstem gliosis
    Toshiko Sawaguchi
    Department of Legal Medicine, School of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Forensic Sci Int 130:S21-9. 2002
  5. ncbi [Sleep disorders in hyperkinetic children--correlation with arousal disorders, differential diagnosis and comorbidity]
    J Frolich
    Klinik und Poliklinik für Psychiatrie und Psychotherapie des Kindes und Jugendalters der Universität zu Köln
    Z Kinder Jugendpsychiatr Psychother 31:133-43. 2003
  6. ncbi Impaired arousals and sudden infant death syndrome: preexisting neural injury?
    Ronald M Harper
    Am J Respir Crit Care Med 168:1262-3. 2003
  7. pmc Approaches to the assessment of arousals and sleep disturbance in children
    Shalini Paruthi
    Pediatric Sleep and Research Center, Department of Pediatrics, Saint Louis University, St Louis, MO 63104, USA
    Sleep Med 11:622-7. 2010
  8. ncbi Parasomnias and movement disorders in children and adolescents
    Elana R Bloomfield
    Department of Psychiatry, University of Michigan Medical School, 2101 Commonwealth Drive, Suite C, Ann Arbor, MI 48105, USA
    Child Adolesc Psychiatr Clin N Am 18:947-65. 2009
  9. ncbi Sleep disorders in children with Attention-Deficit/Hyperactivity Disorder (ADHD) recorded overnight by video-polysomnography
    Rosalia Silvestri
    Sleep Medicine Centre, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
    Sleep Med 10:1132-8. 2009
  10. ncbi Data mining techniques for detection of sleep arousals
    Oren Shmiel
    Department of Computer Science and Mathematics, Bar Ilan University, Ramat Gan 52900, Israel
    J Neurosci Methods 179:331-7. 2009

Research Grants

  1. Neurobiology of Orexin/Hypocretin-Induced Arousal
    CRAIG BERRIDGE; Fiscal Year: 2004
  2. AMPHETAMINE-LIKE STIMULANTS: NOREPINEPHRINE & BEHAVIOR
    CRAIG BERRIDGE; Fiscal Year: 2005
  3. NEUROCHEMISTRY OF AMPHETAMINE INDUCED AROUSAL
    CRAIG BERRIDGE; Fiscal Year: 2008
  4. Obesity and Upper Airway Reflex Control During Sleep
    Susheel Patil; Fiscal Year: 2003
  5. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
  6. Autonomic dysregulation in primary insomnia
    Gary Richardson; Fiscal Year: 2005
  7. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2007
  8. Alcohol, Sleep and Brain Development
    IAN COLRAIN; Fiscal Year: 2008
  9. Sleep Neuroscience in Depression
    Eric Nofzinger; Fiscal Year: 2009

Detail Information

Publications100

  1. ncbi Nonrandom variability of respiration during sleep in healthy humans
    Sven Rostig
    SP Pneumologie, Philipps Universitat Marburg, Schlafmedizinisches Labor, Marburg, Germany
    Sleep 28:411-7. 2005
    ....
  2. ncbi Atypical presentation of NREM arousal parasomnia with repetitive episodes
    N N Trajanovic
    Sleep and Alertness Clinic, University Health Network, Toronto, ON, Canada
    Eur J Neurol 14:947-50. 2007
    ....
  3. pmc Adult obstructive sleep apnea: pathophysiology and diagnosis
    Susheel P Patil
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, MD 21224, USA
    Chest 132:325-37. 2007
    ..Understanding nuances in the spectrum of presenting complaints and polysomnography correlates are important for diagnostic and therapeutic approaches. Knowledge of common patterns of OSA may help to identify patients and guide therapy...
  4. ncbi From epidemiology to physiology and pathology: apnea and arousal deficient theories in sudden infant death syndrome (SIDS)--with particular reference to hypoxic brainstem gliosis
    Toshiko Sawaguchi
    Department of Legal Medicine, School of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Forensic Sci Int 130:S21-9. 2002
    ..In conclusion, the present study sustains the possibility of an organic fragility within the arousal pathway in SIDS victims with repetitive sleep apneas...
  5. ncbi [Sleep disorders in hyperkinetic children--correlation with arousal disorders, differential diagnosis and comorbidity]
    J Frolich
    Klinik und Poliklinik für Psychiatrie und Psychotherapie des Kindes und Jugendalters der Universität zu Köln
    Z Kinder Jugendpsychiatr Psychother 31:133-43. 2003
    ..There are still very few findings on the role of comorbid internal and neurological disorders like sleep apnea and restless legs syndrome in the differential diagnosis of ADHD...
  6. ncbi Impaired arousals and sudden infant death syndrome: preexisting neural injury?
    Ronald M Harper
    Am J Respir Crit Care Med 168:1262-3. 2003
  7. pmc Approaches to the assessment of arousals and sleep disturbance in children
    Shalini Paruthi
    Pediatric Sleep and Research Center, Department of Pediatrics, Saint Louis University, St Louis, MO 63104, USA
    Sleep Med 11:622-7. 2010
    ..Incorporation of autonomic arousal measures-such as heart rate variability, pulse transit time, or peripheral arterial tone-into standard reports may additionally capture subtle sleep fragmentation...
  8. ncbi Parasomnias and movement disorders in children and adolescents
    Elana R Bloomfield
    Department of Psychiatry, University of Michigan Medical School, 2101 Commonwealth Drive, Suite C, Ann Arbor, MI 48105, USA
    Child Adolesc Psychiatr Clin N Am 18:947-65. 2009
    ..This article describes common parasomnias and movement disorders in children and adolescents, with emphasis on psychologic and behavioral comorbidities...
  9. ncbi Sleep disorders in children with Attention-Deficit/Hyperactivity Disorder (ADHD) recorded overnight by video-polysomnography
    Rosalia Silvestri
    Sleep Medicine Centre, Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Messina, Italy
    Sleep Med 10:1132-8. 2009
    ....
  10. ncbi Data mining techniques for detection of sleep arousals
    Oren Shmiel
    Department of Computer Science and Mathematics, Bar Ilan University, Ramat Gan 52900, Israel
    J Neurosci Methods 179:331-7. 2009
    ..2%, positive predictive value=76.5%) with those detected manually by experts. Since the total number of arousals is a measure of sleep quality, this algorithm constitutes a novel approach to automatically estimate sleep quality...
  11. ncbi Impairment of reaction time among children awakened during stage 4 sleep
    Mark Splaingard
    Columbus Children s Hospital, Department of Pediatrics, Columbus, OH, USA
    Sleep 30:104-8. 2007
    ....
  12. ncbi Practice parameters for the indications for polysomnography and related procedures: an update for 2005
    Clete A Kushida
    Stanford University Center of Excellence for Sleep Disorders, Stanford, CA, USA
    Sleep 28:499-521. 2005
    ....
  13. ncbi Dissociated local arousal states underlying essential clinical features of non-rapid eye movement arousal parasomnia: an intracerebral stereo-electroencephalographic study
    Michele Terzaghi
    Sleep Medicine and Epilepsy Unit, IRCCS National Neurological Institute C Mondino Foundation, Pavia, Italy
    J Sleep Res 21:502-6. 2012
    ..The clinical features of the confusional arousals in this patient are highly consistent with a dysfunctional coexistence of local cortical arousal and local cortical sleep...
  14. ncbi A review of the adult primary sleep parasomnias
    Brian Kimble
    Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, 593 Eddy Street APC 4, Providence, RI 02903, USA
    Med Health R I 85:95-8. 2002
  15. ncbi Auditory evoked arousal responses of 3-month-old infants exposed to methamphetamine in utero: a nap study
    Barbara C Galland
    Department of Paediatrics, University of Auckland, New Zealand
    Acta Paediatr 102:424-30. 2013
    ..To investigate whether or not infants exposed to methamphetamine prenatally have impaired arousal responses from sleep...
  16. ncbi Sleep bruxism, an autonomic self-regulating response by triggering the trigeminal cardiac reflex
    Scott E Schames
    Craniofacial Pain TMJ Clinic, White Memorial Medical Center, Los Angeles, USA
    J Calif Dent Assoc 40:670-1, 674-6. 2012
    ..Sleep bruxism by triggering the trigeminal cardiac reflex leads to bradycardia. Rhythmic masticatory muscle activity-sleep bruxism, thereby, serves to slow the heart rate when brain microarousals cause tachycardia...
  17. ncbi [Arousal and motor activity during sleep]
    M A García-Jiménez
    Servicio de Neurofisiologia Clinica, Hospital Virgen de la Luz, Cuenca, Espana
    Rev Neurol 28:559-65. 1999
    ..To describe different types of motor activity which occur during sleep in relation to episodes of arousal and sleep disorder...
  18. ncbi Decreased spontaneous arousability in preterm newborns with impaired neurological outcome
    Gerard Thiriez
    Paediatric Department, Centre Hospitalo Universitaire de Besançon, Universite de Franche Comte, Besancon, France
    J Sleep Res 21:552-60. 2012
    ..These findings suggested that, in preterm infants, perinatal neurological injuries could be associated with an abnormal sleep architecture characterized by altered spontaneous arousability...
  19. ncbi Sleepiness in patients with moderate to severe sleep-disordered breathing
    Vishesh K Kapur
    Department of Medicine, University of Washington Sleep Disorders Center, Box 359803, 325 Ninth Avenue, Seattle, WA 98104, USA
    Sleep 28:472-7. 2005
    ..We investigated the prevalence of sleepiness as well as factors associated with sleepiness in individuals with moderate to severe sleep-disordered breathing (apnea-hypopnea index > or = 15)...
  20. ncbi The effect of sleep duration and quality on academical success of the elementary school children in Kayseri Turkey
    Demet Unalan
    Halil Bayrktar Health Services Vocational College, Kayseri, Turkey
    J Pak Med Assoc 63:576-80. 2013
    ..To assess the sleeping habits of primary school children and establish link between sleeping hours and academic achievement...
  21. ncbi [Primary monosymptomatic enuresis: diagnostics and therapy]
    J Seibold
    Urologische Praxis, Stuttgart, Deutschland
    Urologe A 52:9-10, 12-4. 2013
    ..At the end of therapy a protracted withdrawal shows better results than abrupt cessation...
  22. ncbi Sleep and arousal as risk factors for adverse health and work performance in public health workers involved in the 2004 Florida hurricane season
    Jodi B A McKibben
    Center for the Study of Traumatic Stress, Dept of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Disaster Med Public Health Prep 4:S55-62. 2010
    ..We examined the relation of sleep disturbance and arousal to work performance, mental and physical health, and day-to-day functioning in Florida Department of Health (FDOH) employees 9 months after the 2004 Florida hurricane season...
  23. pmc Disturbed dreaming and the instability of sleep: altered nonrapid eye movement sleep microstructure in individuals with frequent nightmares as revealed by the cyclic alternating pattern
    Peter Simor
    Department of Cognitive Sciences, Budapest University of Technology and Economics, Budapest, Hungary
    Sleep 36:413-9. 2013
    ..Because disrupted sleep might be related to abnormal arousal processes, the goal of this study was to examine polysomnographic arousal-related activities in a group of nightmare sufferers and a healthy control group...
  24. ncbi Arousals are frequent and associated with exacerbated blood pressure response in patients with primary hypertension
    Carlos E V Garcia
    Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Am J Hypertens 26:617-23. 2013
    ..We sought to investigate the frequency and magnitude of blood pressure (BP) increases triggered by spontaneous arousals in patients with primary hypertension...
  25. ncbi Complex nocturnal behaviors: nocturnal seizures and parasomnias
    Nancy Foldvary-Schaefer
    Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Continuum (Minneap Minn) 19:104-31. 2013
    ....
  26. ncbi Sleep-related groaning: prevalence and characteristics in a cohort of patients with suspected obstructive sleep apnea
    Britt Overland
    Sleep Unit, Department of Otorhinolaryngology Head and Neck Surgery, Lovisenberg Diakonale Hospital, Oslo, Norway
    Acta Otolaryngol 132:90-5. 2012
    ..The respiratory tracings in these patients have a distinct appearance that is possible to recognize with a polygraphic recording and thereby prevent the pattern from being misdiagnosed as central apneas...
  27. ncbi Sleep disturbance in pre-school children with obstructive sleep apnoea syndrome
    Lisa M Walter
    The Ritchie Centre, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    Sleep Med 12:880-6. 2011
    ....
  28. ncbi Defining the borders between Sleep-Related Eating Disorder and Night Eating Syndrome
    Piergiuseppe Vinai
    GNOSIS No Profit Research Group, Cuneo, Italy
    Sleep Med 13:686-90. 2012
    ..The aim of this study was to better define psychological, behavioral, and polysomnographic characteristics of the two syndromes...
  29. pmc Noradrenergic modulation of wakefulness/arousal
    Craig W Berridge
    Psychology Department, University of Wisconsin, Madison, WI 53706, USA
    Sleep Med Rev 16:187-97. 2012
    ....
  30. ncbi Nocturnal enuresis
    Michael D Harari
    Continence Clinic and Department of General Medicine, Royal Children s Hospital Melbourne, Parkville, Victoria, Australia
    J Paediatr Child Health 49:264-71. 2013
    ..In turn, these may be associated with constipation and/or faecal soiling. This paper discusses these considerations in the management of NE...
  31. ncbi Cold stimulates the behavioral response to hypoxia in newborn mice
    Bieke Bollen
    INSERM, UMR 676, Robert Debre Teaching Hospital, 75019 Paris, France
    Am J Physiol Regul Integr Comp Physiol 296:R1503-11. 2009
    ..The dissociation between ventilatory and behavioral responses to hypoxia suggests that deficits in the arousal response associated with sleep breathing disorders cannot be attributed to a depressed hypoxic response...
  32. ncbi Nocturnal polyuria and nocturnal arginine vasopressin (AVP): a key factor in the pathophysiology of monosymptomatic nocturnal enuresis
    Diaa AbdelFatah
    Tutor of Urology, Ain Shams University, Cairo, Egypt
    Neurourol Urodyn 28:506-9. 2009
    ..To identify the relationship between nocturnal AVP deficiency, nocturnal polyuria (NP), and low urinary osmolality in children suffering of primary monosymptomatic nocturnal enuresis (NE)...
  33. ncbi Analysis of NREM sleep in children with Prader-Willi syndrome and the effect of growth hormone treatment
    Elisabetta Verrillo
    Respiratory Unit, Bambino Gesu Children s Research Hospital, Piazza S Onofrio 4, Rome, Italy
    Sleep Med 10:646-50. 2009
    ..The aims of our study were to evaluate CAP in children with PWS compared to an age-matched control group and to evaluate the differences between PWS children with (GH+) and without (GH-) GH therapy...
  34. doi Cortical arousal in children with severe enuresis
    Chung K Yeung
    N Engl J Med 358:2414-5. 2008
  35. ncbi Management of sleep disorders in fibromyalgia
    Harvey Moldofsky
    Sleep Disorders Clinic of the Centre for Sleep and Chronobiology, 340 College Street, Suite 580, Toronto, ON M5T 3A9, Canada
    Rheum Dis Clin North Am 28:353-65. 2002
    ..As yet, no medication is known to improve the EEG sleep arousal disorders that include phasic (alpha-delta), tonic alpha non-REM sleep disorders, or the periodic K alpha cycling ..
  36. doi Enuretic sleep: deep, disturbed or just wet?
    Tryggve Neveus
    Pediatr Nephrol 23:1201-2. 2008
    ..It may be hypothesised that the sleep disturbance of enuretic children may lead not only to the wetting of the sheets but to disturbances of daytime psychological functioning as well...
  37. ncbi Coupling of minor motor events and epileptiform discharges with arousal fluctuations in NFLE
    Michele Terzaghi
    Sleep Medicine and Epilepsy Unit, IRCCS C Mondino Institute of Neurology Foundation, Pavia, Italy
    Epilepsia 49:670-6. 2008
    ....
  38. pmc A man with abnormal sleep behavior
    George P Fahed
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center Cleveland, OH 44106 6003, USA
    J Clin Sleep Med 3:533-4. 2007
  39. pmc Disorders of arousal from sleep and violent behavior: the role of physical contact and proximity
    Mark R Pressman
    Sleep Medicine Services, The Lankenau Hospital, Wynnewood, PA 19096, USA
    Sleep 30:1039-47. 2007
    ....
  40. pmc Nonrestorative sleep as a distinct component of insomnia
    Thomas Roth
    Sleep Center, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Sleep 33:449-58. 2010
    ....
  41. ncbi Increased frequency of arousal parasomnias in families with nocturnal frontal lobe epilepsy: a common mechanism?
    Francesca Bisulli
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Epilepsia 51:1852-60. 2010
    ..This study aimed to verify whether relatives of patients with NFLE have a higher frequency of parasomnias, namely arousal disorders, and thereby shed light on the still unknown pathophysiologic mechanisms underlying NFLE...
  42. pmc Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease
    Samay Jain
    Movement Disorders Division, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 3232, USA
    Mov Disord 26:1344-7. 2011
    ..Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease...
  43. ncbi Decreased sleep efficiency, increased wake after sleep onset and increased cortical arousals in late pregnancy
    Danielle L Wilson
    School of Psychological Science, La Trobe University, Bundoora, Victoria, Australia
    Aust N Z J Obstet Gynaecol 51:38-46. 2011
    ..Anecdotal reports of sleep disturbance during pregnancy are abundant; however, objective measurement of sleep changes has so far produced conflicting results...
  44. ncbi In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice
    Richard L Kraus
    Department of Neuroscience, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA
    J Pharmacol Exp Ther 335:409-17. 2010
    ....
  45. pmc NREM arousal parasomnias and their distinction from nocturnal frontal lobe epilepsy: a video EEG analysis
    Christopher P Derry
    Epilepsy Research Centre, Department of Medicine, University of Melbourne, Victoria, Australia
    Sleep 32:1637-44. 2009
    ..To describe the semiological features of NREM arousal parasomnias in detail and identify features that can be used to reliably distinguish parasomnias from nocturnal frontal lobe epilepsy (NFLE)...
  46. ncbi Gender differences in nightmare frequency: a meta-analysis
    Michael Schredl
    Central Institute of Mental Health, Mannheim, Germany
    Sleep Med Rev 15:115-21. 2011
    ....
  47. ncbi Dramatic parasomnias: recognition and treatment
    Gregory Stores
    University of Oxford, Oxford
    Br J Hosp Med (Lond) 71:505-10. 2010
    ..As each of the many parasomnias requires its own specific treatment, confusion between them can have serious consequences. By recognizing their distinctive features, misdiagnosis can be avoided and the appropriate management decided...
  48. ncbi Nocturnal enuresis and overweight are associated with obstructive sleep apnea
    Joseph G Barone
    Division of Urology, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Pediatrics 124:e53-9. 2009
    ..The objective of this study was to examine the relationship of obstructive sleep apnea (OSA), body weight (BMI percentage [BMI%]), and monosymptomatic nocturnal enuresis (MNE) in children...
  49. ncbi Rs 6313 polymorphism in 5-hydroxytryptamine receptor 2A gene association with polysymptomatic primary nocturnal enuresis
    Chang Ching Wei
    Department of Pediatric, China Medical University Hospital, Taichung, Taiwan
    J Clin Lab Anal 24:371-5. 2010
    ..Both TCA and SSRI have similar influences on serotonin transmission. This study was aimed at evaluating whether 5-hydroxytryptamine receptor 2A (5HTR2A) gene is associated with NE...
  50. ncbi Kids that go bump in the night
    Margot Davey
    Melbourne Children s Sleep Unit, Monash Medical Centre, Melbourne, Victoria
    Aust Fam Physician 38:290-4. 2009
    ..These nocturnal events are common in childhood but can be extremely concerning to parents and disruptive to families...
  51. ncbi Violence in sleep
    Francesca Siclari
    Department of Neurology, University Hospital Zurich, Switzerland
    Brain 133:3494-509. 2010
    ..It also discusses current pathophysiological models, establishing a link between sleep-related violence and violence observed in other settings...
  52. ncbi Sleep-related respiratory abnormalities and arousal pattern in achondroplasia during early infancy
    Mathew Ednick
    Department of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr 155:510-5. 2009
    ..To assess sleep-disordered breathing (SDB), sleep architecture, and arousal pattern in infants with achondroplasia and to evaluate the relationship between foramen magnum size and the severity of SDB...
  53. ncbi Arousals in nocturnal groaning
    I Prihodova
    Department of Neurology, Charles University in Prague, General Teaching Hospital, Czech Republic
    Sleep Med 10:1051-5. 2009
    ..We sought to assess its impact on sleep microstructure, i.e., the frequency of arousals relative to the groaning episodes. The frequency, duration and sleep-stage distribution of the groaning episodes were also studied...
  54. ncbi Enuresis nocturna and sleep quality
    Salih Gozmen
    Department of Pediatric Nephrology, Celal Bayar University, Manisa, Turkey
    Pediatr Nephrol 23:1293-6. 2008
    ..So, active treatment (medical or behavioral) should be started as soon as the child is ready to receive it or when the enuretic child wants to be dry when asleep...
  55. ncbi Nocturnal frontal lobe epilepsy and non-rapid eye movement sleep parasomnias: differences and similarities
    Lino Nobili
    Sleep Med Rev 11:251-4. 2007
  56. ncbi [Arousal and its influence on vigilance]
    J Espinar Sierra
    , , Madrid,
    Rev Neurol 28:555-9. 1999
    ..It is concluded that diurnal hyperarousal leads to difficulty in getting off to sleep and staying asleep, whilst nocturnal arousal leads to excessive somnolence during the day, due to broken sleep during the night...
  57. ncbi Paroxysmal events in sleep
    Beth A Malow
    Michael S Aldrich Sleep Disorders Laboratory, University of Michigan, Ann Arbor, 48109 0117, USA
    J Clin Neurophysiol 19:522-34. 2002
    ..Essential historic elements that distinguish these events and the role of video-EEG-polysomnography in their differential diagnosis are emphasized...
  58. ncbi Sleep disturbances in Parkinsonism
    J J M Askenasy
    Department of Neurology, Sackler School of Medicine, Tel Aviv University, Israel
    J Neural Transm 110:125-50. 2003
    ..Each therapeutic approach must be tailored to the individual PD patient...
  59. ncbi Incomplete arousal processes in infants who were victims of sudden death
    Ineko Kato
    Department of Pediatrics, Nagoya City University Medical School, Japan
    Am J Respir Crit Care Med 168:1298-303. 2003
    ..M. (p = 0.011). The present data are suggestive of incomplete arousal processes in infants who eventually died at a time they were presumed to have been asleep...
  60. ncbi Developmental stages of sleep from birth to adolescence, common childhood sleep disorders: overview and nursing implications
    Margaret Ann Carno
    School of Nursing, University of Rochester, Rochester, NY 14642, USA
    J Pediatr Nurs 18:274-83. 2003
    ..This article discusses normal developmental changes related to sleep, common sleep disorders experienced by children and how nurses can assist parents in coping with these changes and disorders...
  61. ncbi The role of sleep and arousal in nocturnal enuresis
    T Neveus
    Uppsala University Chlildren s Hospital, Uppsala, Sweden
    Acta Paediatr 92:1118-23. 2003
    ..To review what is known about the role of sleep and arousal mechanisms in the pathogenesis of nocturnal enuresis...
  62. ncbi Sleep arousal after lower abdominal surgery and relation to recovery from respiratory obstruction
    Aihua Wu
    Department of Anaesthesia, Critical Care, and Pain Medicine, Edinburgh University, Royal Infirmary, United Kingdom
    Anesthesiology 99:1295-302. 2003
    ....
  63. ncbi The effect of maternal smoking on respiratory and arousal patterns in preterm infants during sleep
    Hemant Sawnani
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Respir Crit Care Med 169:733-8. 2004
    ..These alterations in respiratory and arousal patterns in preterm infants born to smoking mothers may lead to significant vulnerability in this population...
  64. ncbi Partial arousal deficiency in SIDS victims and noradrenergic neuronal plasticity
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Early Hum Dev 75:S61-4. 2003
    ..Arousal deficiency in SIDS victims was partial. We could suggest the latent existence of inadequate noradrenergic neuronal plasticity as the background of this partial arousal deficiency of SIDS victims...
  65. ncbi From physiology to pathology: arousal deficiency theory in sudden infant death syndrome (SIDS)--with reference to apoptosis and neuronal plasticity
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Forensic Sci Int 130:S37-43. 2002
    ..This autonomic response occurs within an acetylcholine afferent system and pedunculopontine tegmental nucleus (PPTN). The finding is, in future SIDS infants, associated with repetitive sleep apnea...
  66. ncbi Sudden infant deaths: from epidemiology to physiology
    A Kahn
    Pediatric Sleep Unit, University Children s Hospital of Brussels, Free University of Brussels, Av JJ Crocq 15, B 1020 Brussels, Belgium
    Forensic Sci Int 130:S8-20. 2002
    ..Although the description of the mechanisms responsible for SIDS is still far from complete, it appears to involve both arousal responses and cardiac autonomic controls during sleep-wake processes...
  67. ncbi Identifying montages that best detect electrographic seizure activity during polysomnography
    N Foldvary
    Department of Neurology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Sleep 23:221-9. 2000
    ..The purpose of this study was to determine the value of limited EEG montages viewed with EEG reformatting capability in the identification of seizures during PSG...
  68. ncbi Relationship of temporal lobe seizures to sleep and arousal: a combined scalp-intracranial electrode study
    A Malow
    Department of Neurology, University of Michigan Medical School, Ann Arbor, USA
    Sleep 23:231-4. 2000
    ..To examine the question of whether seizures precede or follow arousals from sleep, we defined the timing of temporal lobe seizures in relation to sleep and arousal using combined scalp-intracranial electrodes...
  69. ncbi Practice parameters for the evaluation of chronic insomnia. An American Academy of Sleep Medicine report. Standards of Practice Committee of the American Academy of Sleep Medicine
    A Chesson
    Neurology Department, Louisiana State University Medical Center, Shreveport, USA
    Sleep 23:237-41. 2000
    ....
  70. ncbi NREM parasomnias: arousal disorders and differentiation from nocturnal frontal lobe epilepsy
    M Zucconi
    Sleep Disorders Center, Department of Neurology, H San Raffaele Scientific Institute, Via Stamira d Ancona 20, 20127, Milano, Italy
    Clin Neurophysiol 111:S129-35. 2000
    ..In any case the diagnosis of NFLE should be considered in children with nocturnal motor episodes or nocturnal motor agitation, when the attacks persist; this diagnosis is probably more frequent than expected...
  71. ncbi Nociceptive responsiveness during slow-wave sleep and waking in the rat
    P Mason
    Dept of Neurobiology, Pharmacology, and Physiology and the Committee on Neurobiology, University of Chicago, IL 60637, USA
    Sleep 24:32-8. 2001
    ..Therefore, pain evokes at least two distinct reactions that are differentially modulated across sleep/wake cycles...
  72. ncbi Combined influence of cyclic arousability and EEG synchrony on generalized interictal discharges within the sleep cycle
    L Parrino
    Istituto di Neurologia, , Via del Quartiere 4, 43100, Parma, Italy
    Epilepsy Res 44:7-18. 2001
    ....
  73. ncbi Impaired circadian waking arousal in narcolepsy-cataplexy
    R Broughton
    Sleep and Chronobiology Research Center, Division of Neurology, University of Ottawa, Ottawa, Ontario
    Sleep Res Online 1:159-65. 1998
    ....
  74. ncbi Sleep disorders in childhood: a review
    M Mazza
    Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, Italy
    Clin Ter 153:189-93. 2002
    ....
  75. ncbi Efficacy of pergolide in treatment of restless legs syndrome: the PEARLS Study
    C Trenkwalder
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Neurology 62:1391-7. 2004
    ..To evaluate the short- and long-term safety and efficacy of pergolide therapy for restless legs syndrome (RLS) in a double-blind, placebo-controlled, randomized trial (Pergolide European Australian RLS [PEARLS] study)...
  76. ncbi Prevalence of diurnal voiding symptoms and difficult arousal from sleep in children with nocturnal enuresis
    Manju Chandra
    Division of Pediatric Nephrology, Schneider Children s Hospital at North Shore and North Shore University Hospital, Manhasset, New York 11030, USA
    J Urol 172:311-6. 2004
    ....
  77. ncbi Movement disorders in sleep: guidelines for differentiating epileptic from non-epileptic motor phenomena arising from sleep
    Paolo Tinuper
    Department of Neurological Sciences, University of Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy
    Sleep Med Rev 11:255-67. 2007
    ..Further investigations on pathophysiology, genetics and epidemiology are needed to clarify the relationship between epileptic and non-epileptic sleep related paroxysmal phenomena...
  78. ncbi Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients
    Nico J Diederich
    Department of Neuroscience, Centre Hospitalier de Luxembourg, Luxembourg
    Mov Disord 20:1413-8. 2005
    ..Longitudinal studies of patients with such "abortive" SAS are warranted to establish if this finding reflects benign nocturnal respiratory muscle dyskinesia or constitutes a precursor sign of dysautonomia in PD...
  79. ncbi Paroxysmal motor disorders of sleep: the clinical spectrum and differentiation from epilepsy
    Christopher P Derry
    Epilepsy Research Centre and Department of Medicine Neurology, University of Melbourne, Australia
    Epilepsia 47:1775-91. 2006
    ..The value of recording episodes with video EEG polysomnography is discussed...
  80. ncbi Hyperarousal, depression and quality of life--validity and reliability of the Swedish version of the Hyperarousal Scale
    Ulla Edéll-Gustafsson
    Department of Medicine and Care, Nursing Science, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Scand J Caring Sci 20:58-67. 2006
    ....
  81. ncbi Sleep bruxism is associated to micro-arousals and an increase in cardiac sympathetic activity
    N Huynh
    Facultés de Médecine Dentaire et de Médecine, Universite de Montreal, Montreal, QC, Canada
    J Sleep Res 15:339-46. 2006
    ..03). In moderate to severe SB subjects, a clear increase in sympathetic activity precedes SB onset...
  82. ncbi Sleep quality of patients with acute myocardial infarction outside the CCU environment: a preliminary study
    Ahmed BaHammam
    Sleep Disorders Center and Medical Intensive Care Unit, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Med Sci Monit 12:CR168-72. 2006
    ..We hypothesized that myocardial infarction may disturb sleep architecture regardless of the surrounding environmental factors...
  83. ncbi Rehabilitation is compromised by arousal and sleep disorders: results of a survey of rehabilitation centres
    Andrew D Worthington
    Brain Injury Rehabilitation Trust, Birmingham, UK
    Brain Inj 20:327-32. 2006
    ..To investigate the impact of disorders of arousal and sleep disturbance on everyday living and participation in rehabilitation...
  84. ncbi Non-epileptic paroxysmal manifestations during sleep in infancy and childhood
    L Fusco
    Division of Neurology Bambin Gesù, Children s Hospital Scientific Institute, Piazza S Onofrio 4, I 00165 Rome, Italy
    Neurol Sci 26:s205-9. 2005
    ..The widespread use of neurophysiological techniques and better knowledge of the semeiology of epileptic seizures have led us to correctly define these events, which have sometimes been erroneously treated in the past...
  85. ncbi The K-complex: a 7-decade history
    Ian M Colrain
    Human Sleep Research Program, SRI international and Department of Psychology, The University of Melbourne, Melbourne, Australia
    Sleep 28:255-73. 2005
    ....
  86. ncbi Recurrent nightmares and disorders of arousal in temporal lobe epilepsy
    Rosalia Silvestri
    Department of Neurology, Harvard Medical School, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Brain Res Bull 63:369-76. 2004
    ..A better seizure control with improved quality of life can be achieved by increasing and extending the practice of nocturnal recording in TLE patients...
  87. ncbi South African guidelines for the management of nocturnal enuresis
    J C van Dyk
    S Afr Med J 93:338-40. 2003
  88. ncbi Effects of maternal cigarette smoking and cocaine use in pregnancy on fetal response to vibroacoustic stimulation and habituation
    J L Gingras
    Department of Pediatrics, University of North Carolina Chapel Hill, North Carolina, USA
    Acta Paediatr 93:1479-85. 2004
    ..Although the cause of SIDS is not known, one postulated mechanism involves abnormalities of arousal and arousal regulation. Cigarette smoking and cocaine use may cause deficits of arousal. Many believe arousal deficits occur prenatally...
  89. ncbi Functional neuroimaging evidence for hyperarousal in insomnia
    Eric A Nofzinger
    Western Psychiatric Institute and Clinic, Sleep Neuroimaging Research Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 161:2126-8. 2004
    ..The authors investigated the neurobiological basis of poor sleep and daytime fatigue in insomnia...
  90. ncbi Microarousals during sleep are associated with increased levels of lipids, cortisol, and blood pressure
    Mirjam Ekstedt
    Department of Public Health Science, Karolinska Institutet, Stockholm, Sweden
    Psychosom Med 66:925-31. 2004
    ..A second purpose was to relate the number of arousals to mood, stress, work characteristics, and other possible predictors in daily life...
  91. pmc Sleep . 8: paediatric obstructive sleep apnoea
    G M Nixon
    Department of Pediatrics, Montreal Children s Hospital, 2300 rue Tupper, Montreal, Quebec H3H 1P3, Canada
    Thorax 60:511-6. 2005
    ..Diagnosis and treatment of this condition in children differs in many respects from that in adults. We review here the key features of paediatric OSA, highlighting differences from adult OSA, and suggest future directions for research...
  92. ncbi REM sleep behavior disorder and other sleep disturbances in Disney animated films
    Alex Iranzo
    Neurology Service, Hospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer IDIBAPS, C Villarroel 170, Barcelona 08036, Spain
    Sleep Med 8:531-6. 2007
    ..These sleep disorders were inserted as comic elements. The inclusion of a broad range of accurately depicted sleep disorders in these films indicates that the Disney screenwriters were astute observers of sleep and its disorders...
  93. ncbi Future directions in the management of insomnia
    G S Richardson
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Mich 48202, USA
    J Clin Psychiatry 62:39-45. 2001
    ..It remains unclear, however, whether this activation is primary or secondary to the insomnia itself. If physiologic hyperarousal causes primary insomnia, it would provide new approaches to the management of this disorder...
  94. ncbi Sleep disturbances associated with minor psychiatric disorders in medical students
    M P Hidalgo
    Psychiatric Service, Hospital Presidente Vargas, Porto Alegre, Brazil
    Neurol Sci 23:35-9. 2002
    ..56], and sleeping less than 7 hours per night [OR, 2.02; 95% CI, 1.11-3.67] were associated with minor psychiatric disorders. This group of variables determined a cumulative risk ratio of 5.47 [95% CI, 2.87-10.41] for the main outcome...
  95. ncbi Fever-associated confusional arousal
    Carmen H Larsen
    Paediatric Neurology Division, IWK Health Centre, 5850 University Avenue, B3J 3G9, Halifax, Nova Scotia, Canada
    Eur J Pediatr 163:696-7. 2004
  96. ncbi Non-REM sleep instability in patients with major depressive disorder: subjective improvement and improvement of non-REM sleep instability with treatment (Agomelatine)
    M Cecilia Lopes
    Stanford University Sleep Medicine Program, Sleep Disorders Clinic, Garches, France
    Sleep Med 9:33-41. 2007
    ....
  97. ncbi Association between sleep apnea and reactive astrocytes in brainstems of victims of SIDS and in control infants
    Toshiko Sawaguchi
    Department of Legal Medicine, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Forensic Sci Int 130:S30-6. 2002
    ....
  98. ncbi Adolescent pertussis-induced partial arousal parasomnia
    Tal Eidlitz-Markus
    Day Hospitalization Unit, Schneider Children s Medical Center of Israel, Petah Tiqwa, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pediatr Neurol 35:264-7. 2006
    ..In conclusion, partial arousal parasomnia may be induced by pertussis infection. Further studies in larger groups are required to confirm this association...
  99. doi Dealing with pediatric sleep disorders can call for a wide range of expertise
    Lynne Lamberg
    JAMA 299:2497-8. 2008
  100. ncbi Sleep and breathing in Prader-Willi syndrome
    Gillian M Nixon
    Department of Pediatrics, Montreal Children s Hospital, McGill University, Montreal, Quebec, Canada
    Pediatr Pulmonol 34:209-17. 2002
    ..Treatment options depend on the underlying problem, but may include behavioral interventions, weight control, adenotonsillectomy, and nocturnal ventilation...

Research Grants9

  1. Neurobiology of Orexin/Hypocretin-Induced Arousal
    CRAIG BERRIDGE; Fiscal Year: 2004
    ..These studies will provide a better understanding of the neurobiology of orexin, the neurobiology of sleep and waking, and the potential role of orexin in narcolepsy and other disorders of arousal. ..
  2. AMPHETAMINE-LIKE STIMULANTS: NOREPINEPHRINE & BEHAVIOR
    CRAIG BERRIDGE; Fiscal Year: 2005
    ..Information obtained in these studies may provide insight into mechanisms subserving, and treatment of, stimulant drug abuse. ..
  3. NEUROCHEMISTRY OF AMPHETAMINE INDUCED AROUSAL
    CRAIG BERRIDGE; Fiscal Year: 2008
    ..Information obtained in these studies may provide insight into mechanisms underlying, and future treatment of, stimulant drug abuse, ADHD and narcolepsy. ..
  4. Obesity and Upper Airway Reflex Control During Sleep
    Susheel Patil; Fiscal Year: 2003
    ..This proposal combines state-of- the-art polysomnographic, physiologic, and epidemiologic methods to build a mechanistic understanding of the role of adiposity in the pathogenesis of OSA. ..
  5. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  6. Autonomic dysregulation in primary insomnia
    Gary Richardson; Fiscal Year: 2005
    ..Finally, we will use a new measure of central CRF function, the DEX-sleep latency test, to test the hypothesis that central CRF tone is higher in patients with P1. ..
  7. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2007
    ..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
  8. Alcohol, Sleep and Brain Development
    IAN COLRAIN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Sleep Neuroscience in Depression
    Eric Nofzinger; Fiscal Year: 2009
    ..Multiple linear regressions will be used to test the mediational models above. Findings from this study are expected to significantly advance our understanding of the neuroscience of depression. ..