restless legs syndrome

Summary

Summary: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep. Complying with an irresistible urge to move the affected limbs brings temporary relief. Sleep may become disrupted, resulting in excessive daytime hypersomnolence. This condition may be associated with UREMIA; DIABETES MELLITUS; and rheumatoid arthritis. Restless Legs Syndrome differs from NOCTURNAL MYOCLONUS SYNDROME in that in the latter condition the individual does not report adverse sensory stimuli and it is primarily a sleep-associated movement disorder. (Adams et al., Principles of Neurology, 6th ed, p387; Schweiz Rundsch Med Prax 1997 Apr 30;86(18):732-736)

Top Publications

  1. ncbi Restless legs syndrome prevalence and impact: REST general population study
    Richard P Allen
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21224, USA
    Arch Intern Med 165:1286-92. 2005
  2. pmc Prospective study of restless legs syndrome and coronary heart disease among women
    Yanping Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Circulation 126:1689-94. 2012
  3. ncbi Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk: a systematic review
    Kim E Innes
    Department of Community Medicine, West Virginia University School of Medicine, PO Box 9190, Morgantown, WV 26506 9190, USA
    Sleep Med Rev 16:309-39. 2012
  4. ncbi The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Grou
    Marco Zucconi
    Sleep Disorders Center, San Raffaele Hospital, Milano, Italy
    Sleep Med 7:175-83. 2006
  5. ncbi Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study
    Wolfgang Oertel
    Philipps Universitat, Marburg, Germany
    Lancet Neurol 10:710-20. 2011
  6. pmc Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome
    Amanda Freeman
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 22:1142-8. 2012
  7. ncbi Restless legs syndrome
    Karl Ekbom
    Department of Neurology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sleep Disorders Center, Avesta Hospital, Stockholm, Sweden
    J Intern Med 266:419-31. 2009
  8. ncbi Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health
    Richard P Allen
    Department of Neurology, Sleep Medicine, Johns Hopkins Bayview Medical Center, Asthma and Allergy Building 1B46b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 4:101-19. 2003
  9. ncbi Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study
    John W Winkelman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
    Neurology 70:35-42. 2008
  10. ncbi Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort
    John W Winkelman
    Division of Sleep Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02459, USA
    Sleep Med 7:545-52. 2006

Detail Information

Publications336 found, 100 shown here

  1. ncbi Restless legs syndrome prevalence and impact: REST general population study
    Richard P Allen
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21224, USA
    Arch Intern Med 165:1286-92. 2005
    b>Restless legs syndrome (RLS), a common sensorimotor disorder, has a wide range of severity from merely annoying to affecting sleep and quality of life severely enough to warrant medical treatment...
  2. pmc Prospective study of restless legs syndrome and coronary heart disease among women
    Yanping Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Circulation 126:1689-94. 2012
    Previous cross-sectional studies suggested a positive association between restless legs syndrome (RLS) and coronary heart disease (CHD). This observation was not confirmed by subsequent prospective studies...
  3. ncbi Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk: a systematic review
    Kim E Innes
    Department of Community Medicine, West Virginia University School of Medicine, PO Box 9190, Morgantown, WV 26506 9190, USA
    Sleep Med Rev 16:309-39. 2012
    b>Restless legs syndrome (RLS) is a distressing sleep and sensorimotor disorder that affects a large percentage of adults in the western industrialized world and is associated with profound reductions in quality of life...
  4. ncbi The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Grou
    Marco Zucconi
    Sleep Disorders Center, San Raffaele Hospital, Milano, Italy
    Sleep Med 7:175-83. 2006
  5. ncbi Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study
    Wolfgang Oertel
    Philipps Universitat, Marburg, Germany
    Lancet Neurol 10:710-20. 2011
    Safety and efficacy of non-ergot dopamine agonists for the treatment of idiopathic restless legs syndrome have been shown in short-term trials...
  6. pmc Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome
    Amanda Freeman
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 22:1142-8. 2012
    b>Restless Legs Syndrome (RLS), first chronicled by Willis in 1672 and described in more detail by Ekbom in 1945, is a prevalent sensorimotor neurological disorder (5%-10% in the population) with a circadian predilection for the evening and ..
  7. ncbi Restless legs syndrome
    Karl Ekbom
    Department of Neurology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sleep Disorders Center, Avesta Hospital, Stockholm, Sweden
    J Intern Med 266:419-31. 2009
    b>Restless legs syndrome (RLS) is a common neurological sensory-motor disorder that is characterized by intense restlessness and unpleasant creeping sensations deep inside the lower legs...
  8. ncbi Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health
    Richard P Allen
    Department of Neurology, Sleep Medicine, Johns Hopkins Bayview Medical Center, Asthma and Allergy Building 1B46b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 4:101-19. 2003
    b>Restless legs syndrome is a common yet frequently undiagnosed sensorimotor disorder. In 1995, the International Restless Legs Syndrome Study Group developed standardized criteria for the diagnosis of restless legs syndrome...
  9. ncbi Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study
    John W Winkelman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
    Neurology 70:35-42. 2008
    We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects.
  10. ncbi Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin Sleep Cohort
    John W Winkelman
    Division of Sleep Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02459, USA
    Sleep Med 7:545-52. 2006
    The aim of this study was to estimate the prevalence of restless legs syndrome (RLS) symptoms in the US adult population and to relate frequency of RLS symptoms to self-reported general health, depressive and anxiety symptoms, daytime ..
  11. ncbi Exploring the relationship between Parkinson disease and restless legs syndrome
    William G Ondo
    Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030
    Arch Neurol 59:421-4. 2002
    b>Restless legs syndrome (RLS) and Parkinson disease (PD) are common neurological conditions that respond to dopaminergic therapy. To our knowledge, the relationship between the two has not been thoroughly explored.
  12. ncbi Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective
    Stefan Clemens
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurology 67:125-30. 2006
    b>Restless legs syndrome (RLS) involves abnormal limb sensations that diminish with motor activity, worsen at rest, have a circadian peak in expression in the evening and at night, and can severely disrupt sleep...
  13. ncbi Restless legs syndrome: understanding its consequences and the need for better treatment
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep Med 11:807-15. 2010
    b>Restless legs syndrome (RLS) is a very common neurologic disorder with a prevalence of disease resulting in moderate and severe health impact of at least 2.7%...
  14. ncbi Prevalence of restless legs syndrome and periodic limb movement disorder in the general population
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, 401 Quarry Road Suite 3301, Stanford, CA 94305, USA
    J Psychosom Res 53:547-54. 2002
    Periodic limb movement disorder (PLMD) and restless legs syndrome (RLS) are two sleep disorders characterized by abnormal leg movements and are responsible for deterioration in sleep quality...
  15. ncbi Cardiovascular risk factors in restless legs syndrome
    Ilana Schlesinger
    Department of Neurology, Rambam Health Care Campus, Haifa, Israel
    Mov Disord 24:1587-92. 2009
    ..cross-sectional study to assess prevalence of cardiovascular risk factors in subjects with and without restless legs syndrome (RLS)...
  16. ncbi New approaches to the study of periodic leg movements during sleep in restless legs syndrome
    Raffaele Ferri
    Sleep Research Centre, Department of Neurology I C, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Troina, Italy
    Sleep 29:759-69. 2006
    To describe a new approach for the analysis of quantity, type, and periodicity of the leg motor activity during sleep in patients with restless legs syndrome (RLS) and periodic leg movements (PLM).
  17. pmc Epidemiology of restless legs syndrome in Korean adults
    Yong Won Cho
    Department of Neurology, Dongsan Medical Center, Keimyung University, Daegu, Korea
    Sleep 31:219-23. 2008
    To investigate the prevalence of restless legs syndrome (RLS) in Korea.
  18. ncbi Hypoxia-inducible factor pathway activation in restless legs syndrome patients
    S M Patton
    Milton S Hershey Medical Center, Department of Neurosurgery, Penn State University, Hershey, PA 17033, USA
    Eur J Neurol 18:1329-35. 2011
    These studies tested the hypothesis that hypoxia inducible factor-1α (HIF-1α) pathway activation occurs in substantia nigra neurons and brain microvasculature in patients with restless legs syndrome.
  19. ncbi Severity of restless legs syndrome is inversely correlated with echogenicity of the substantia nigra in different neurodegenerative movement disorders. a preliminary observation
    Jose Luiz Pedroso
    Department of Neurology and Neurosurgery, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    J Neurol Sci 319:59-62. 2012
    ..Additionally, restless legs syndrome is a sleep disorder that is also frequently found in both diseases...
  20. pmc Restless legs syndrome and hypertension in middle-aged women
    Salma Batool-Anwar
    Harvard Medical School, Brigham and Women s Hospital, Division of Sleep Medicine, 221 Longwood Ave, BL1044, Boston, MA 02115, USA
    Hypertension 58:791-6. 2011
    Limited research suggests a relationship between restless legs syndrome and hypertension. We, therefore, assessed the relationship between restless legs syndrome and hypertension among middle-aged women...
  21. pmc Profile of altered brain iron acquisition in restless legs syndrome
    James R Connor
    Department of Neurosurgery H110, G M Leader Family Laboratory for Alzheimer s Disease Research, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Brain 134:959-68. 2011
    b>Restless legs syndrome is a neurological disorder characterized by an urgency to move the legs during periods of rest...
  22. pmc Vascular risk factors, cardiovascular disease, and restless legs syndrome in men
    Anke C Winter
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Am J Med 126:228-35, 235.e1-2. 2013
    The prevalence of vascular risk factors, cardiovascular disease, and restless legs syndrome increases with age...
  23. ncbi Time-dependent variation in cerebral and autonomic activity during periodic leg movements in sleep: implications for arousal mechanisms
    Emilia Sforza
    Sleep Laboratory, Department of Psychiatry, Geneva University Hospital, 2 Chemin du Petit Bel Air, 1225 Chene Bourg, Geneva, Switzerland
    Clin Neurophysiol 113:883-91. 2002
    ..To address the question as to whether the same continuum may be proposed in sleep disorders, we performed temporal spectral EEG and HR analyses during periodic leg movements (PLM) associated or not with microarousal (MA)...
  24. pmc Analysis of the C9orf72 repeat in Parkinson's disease, essential tremor and restless legs syndrome
    Mariely DeJesus-Hernandez
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 19:198-201. 2013
    ..repeat length with susceptibility to Parkinson's disease and related disorders, essential tremor and restless legs syndrome. One restless legs syndrome patient was shown to harbor a repeat expansion, however on clinical follow-up ..
  25. ncbi Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep
    Mauro Manconi
    Sleep Disorders Center, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Vita Salute University, Milan, Italy
    Sleep Med 12:47-55. 2011
    To compare heart rate variability (HRV) changes in patients with restless legs syndrome (RLS) and in healthy subjects, and to evaluate HRV before and after treatment with pramipexole in RLS patients.
  26. ncbi Restless legs syndrome as side effect of second generation antidepressants
    Klaus G Rottach
    Hafenmarkt 12, 87600 Kaufbeuren, Germany
    J Psychiatr Res 43:70-5. 2008
    ..interest, the question is still not fully answered whether antidepressants (AD) can cause or exacerbate restless legs syndrome (RLS). The literature provides contradictory information...
  27. pmc High prevalence of restless legs syndrome among patients with fibromyalgia: a controlled cross-sectional study
    Mari Viola-Saltzman
    Department of Neurology, Loyola University Medical Center Maywood, IL, USA
    J Clin Sleep Med 6:423-7. 2010
    To investigate the prevalence of restless legs syndrome (RLS) in fibromyalgia (FM) and determine the presence and amount of sleep disruption in FM patients with RLS...
  28. pmc A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome
    Daniel O Lee
    Sleep Disorders Center, East Carolina Neurology, Inc, Greenville, NC 27834, USA
    J Clin Sleep Med 7:282-92. 2011
    To evaluate the efficacy and tolerability of gabapentin enacarbil (GEn) 1200 mg or 600 mg compared with placebo in subjects with moderate-to-severe primary restless legs syndrome (RLS).
  29. pmc Algorithms for the diagnosis and treatment of restless legs syndrome in primary care
    Diego Garcia-Borreguero
    Sleep Research Institute, Madrid, Spain
    BMC Neurol 11:28. 2011
    b>Restless legs syndrome (RLS) is a neurological disorder with a lifetime prevalence of 3-10%. in European studies. However, the diagnosis of RLS in primary care remains low and mistreatment is common.
  30. ncbi Gabapentin enacarbil in restless legs syndrome: a phase 2b, 2-week, randomized, double-blind, placebo-controlled trial
    Arthur S Walters
    Department of Neurology, Vanderbilt University Medical Center, 1161 21st Ave, Nashville, TN 37232 2551, USA
    Clin Neuropharmacol 32:311-20. 2009
    Assess the efficacy and tolerability of gabapentin enacarbil (GEn), a transported prodrug of gabapentin with improved gabapentin exposure, in adults with moderate-to-severe primary restless legs syndrome.
  31. pmc Impulse control disorders with the use of dopaminergic agents in restless legs syndrome: a case-control study
    Jason R Cornelius
    Center for Sleep Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Sleep 33:81-7. 2010
    To determine the frequency of impulse control disorders (ICDs) with the use of dopaminergic agents in restless legs syndrome (RLS).
  32. ncbi Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms
    J Ulfberg
    Department of Medical Sciences Occupational and Environmental Medicine, University Hospital, Uppsala, Sweden
    Mov Disord 16:1159-63. 2001
    Standardized diagnostic criteria determined by the International Restless Legs Syndrome Study Group were used to investigate the current prevalence of restless legs syndrome (RLS)...
  33. ncbi Sex and the risk of restless legs syndrome in the general population
    Klaus Berger
    Institute of Epidemiology and Social Medicine, University of Munster, Germany
    Arch Intern Med 164:196-202. 2004
    b>Restless legs syndrome (RLS) is characterized by the desire to move the limbs associated with paresthesias of the legs, a motor restlessness, an intensification of symptoms at rest with relief by activity, and a worsening of symptoms in ..
  34. ncbi The evoked heart rate response to periodic leg movements of sleep
    J W Winkelman
    Sleep Disorders Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sleep 22:575-80. 1999
    ..It appears premature to conclude that periodic leg movements of sleep not associated with visible EEG arousal are clinically insignificant...
  35. pmc Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1
    Juliane Winkelmann
    Institute of Human Genetics, Technische Universitat Munchen, Munich, Germany
    PLoS Genet 7:e1002171. 2011
    b>Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age...
  36. ncbi Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study
    D Garcia-Borreguero
    Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
    Neurology 59:1573-9. 2002
    To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS).
  37. ncbi Prevalence of restless legs syndrome among adults in Iceland and Sweden: Lung function, comorbidity, ferritin, biomarkers and quality of life
    Bryndis Benediktsdottir
    Faculty of Medicine, University of Iceland, Iceland
    Sleep Med 11:1043-8. 2010
    This study investigates the prevalence and the association between restless legs syndrome (RLS) and a large variety of health variables in two well-characterized random samples from the general population in Reykjavik, Iceland, and ..
  38. ncbi Iron and the restless legs syndrome
    E R Sun
    Johns Hopkins University Dept. of Psychology, Baltimore, MD, USA
    Sleep 21:371-7. 1998
    ..the relation between serum ferritin levels and severity of subjective and objective symptoms of the restless legs syndrome (RLS) for a representative patient sample covering the entire adult age range...
  39. ncbi "Anxietas tibiarum". Depression and anxiety disorders in patients with restless legs syndrome
    J Winkelmann
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurol 252:67-71. 2005
    Symptoms of anxiety and depression in patients with restless legs syndrome (RLS) have been observed...
  40. ncbi Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literature
    Samuele Cortese
    Service de Psychopathologie de l Enfant et de l Adolescent, Hopital Robert Debre, Paris, France
    Sleep 28:1007-13. 2005
    To review evidence on the association between restless legs syndrome (RLS) and attention-deficit/hyperactivity disorder (ADHD), to discuss the hypothetical mechanisms underlying this association, and to consider the potential interest for ..
  41. ncbi Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study
    Wayne Hening
    Department of Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
    Sleep Med 5:237-46. 2004
    To assess the frequency, impact, and medical response to the restless legs syndrome (RLS) in a large multi-national primary care population.
  42. ncbi An algorithm for the management of restless legs syndrome
    Michael H Silber
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:916-22. 2004
    b>Restless legs syndrome (RLS) is a common disorder with a prevalence of 5% to 15%. Primary care physicians must become familiar with management of this disorder...
  43. pmc Frequent periodic leg movement during sleep is associated with left ventricular hypertrophy and adverse cardiovascular outcomes
    Mahek Mirza
    Center for Integrative Research on Cardiovascular Aging, Aurora University of Wisconsin Medical Group, Milwaukee, Wisconsin 53215, USA
    J Am Soc Echocardiogr 26:783-90. 2013
    ..However, the effect of restless legs syndrome, another common cause of fragmented sleep, on cardiac structure, function, and long-term outcomes is not ..
  44. ncbi The genetics of sleep disorders in humans: narcolepsy, restless legs syndrome, and obstructive sleep apnea syndrome
    Emrah Caylak
    Department of Biochemistry and Clinical Biochemistry, Firat University, School of Medicine, Elazig, Turkey
    Am J Med Genet A 149:2612-26. 2009
    ..evidence emerging for the presence of genes influencing sleep disorders, such as narcolepsy (NRCLP), restless legs syndrome (RLS), and obstructive sleep apnea syndrome (OSAS)...
  45. pmc Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome
    Qinbo Yang
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Mov Disord 26:516-9. 2011
    We previously mapped a genetic locus for restless legs syndrome (RLS) to chromosome 9p22-24 (RLS3) and a later genome-wide association study (GWAS) implicated the PTPRD gene at the RLS3 locus as a susceptibility gene for RLS...
  46. ncbi Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists
    M Tippmann-Peikert
    Mayo Clinic Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 68:301-3. 2007
    ..We report three patients treated in our sleep disorders center who developed pathologic gambling while receiving treatment with dopamine agonists for restless legs syndrome.
  47. ncbi Night-to-night variability of periodic leg movements during sleep in restless legs syndrome and periodic limb movement disorder: comparison between the periodicity index and the PLMS index
    Raffaele Ferri
    Sleep Research Centre, Department of Neurology I C, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Troina, Italy
    Sleep Med 14:293-6. 2013
    ..It is currently not known if this is also the case for the degree of periodicity of leg movements, quantified by the Periodicity index...
  48. ncbi Restless legs syndrome and periodic leg movements of sleep
    David B Rye
    Program in Sleep, Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, WMRB Office 6113, Atlanta, GA 30322, USA
    Neurol Clin 30:1137-66. 2012
    Women are more commonly affected than men by restless legs syndrome, and prevalence is highest amongst those of northern European heritage. The motor manifestations include nonvolitional myoclonus (periodic leg movements)...
  49. ncbi Ropinirole as a treatment of restless legs syndrome in patients on chronic hemodialysis: an open randomized crossover trial versus levodopa sustained release
    Maria Teresa Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Clin Neuropharmacol 27:178-81. 2004
    b>Restless legs syndrome (RLS) is a common neurologic condition characterized by uncomfortable and unpleasant sensations in the legs, occurring primarily at rest, which are usually worse in the evening and are alleviated by movement...
  50. ncbi Randomized trial of pramipexole for patients with restless legs syndrome (RLS) and RLS-related impairment of mood
    Pasquale Montagna
    Dipartimento di Scienze Neurologiche, Universita degli Studi di Bologna, Bologna, Italy
    Sleep Med 12:34-40. 2011
    Patients with restless legs syndrome (RLS) have an elevated prevalence of mood disorders compared with the general population...
  51. pmc Vascular risk factors, cardiovascular disease, and restless legs syndrome in women
    Anke C Winter
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Am J Med 126:220-7, 227.e1-2. 2013
    Previous studies evaluating the association of cardiovascular disease and vascular risk factors with restless legs syndrome showed inconsistent results, especially for the potential relation between various vascular risk factors and ..
  52. ncbi Dopamine and iron in the pathophysiology of restless legs syndrome (RLS)
    Richard Allen
    Neurology and Sleep Medicine, Johns Hopkins Bayview Medical Center, Asthma and Allergy Bldg 1B46b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 5:385-91. 2004
    The evaluation of the pathophysiology of restless legs syndrome (RLS) stems largely from recognition of the information provided by both pharmacological treatment of the disorder and the secondary forms of the disorder...
  53. ncbi Evaluating the quality of life of patients with restless legs syndrome
    Linda Abetz
    Mapi Values Ltd, Bollington, Macclesfield, United Kingdom
    Clin Ther 26:925-35. 2004
    The primary morbidities of restless legs syndrome (RLS) involve sleep loss, extreme discomfort, and disruption of normal activities...
  54. ncbi Non-pharmacological management of periodic limb movements during hemodialysis session in patients with uremic restless legs syndrome
    Christoforos D Giannaki
    Department of Nephrology, School of Medicine, University of Thessaly, Larissa, Greece
    ASAIO J 56:538-42. 2010
    b>Restless legs syndrome (RLS) is very common in hemodialysis patients. RLS induces motor excitability and discomfort during rest periods, and those symptoms have also been observed during hemodialysis sessions...
  55. pmc The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline
    R Nisha Aurora
    Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Sleep 35:1039-62. 2012
    ..Lastly, therapies for PLMD are reviewed. However, it should be mentioned that because PLMD therapy typically mimics RLS therapy, the primary focus of this review is therapy for idiopathic RLS...
  56. pmc Evidence of increased muscle atrophy and impaired quality of life parameters in patients with uremic restless legs syndrome
    Christoforos D Giannaki
    Department of Nephrology, University of Thessaly, Larissa, Thessaly, Greece
    PLoS ONE 6:e25180. 2011
    b>Restless Legs Syndrome is a very common disorder in hemodialysis patients...
  57. ncbi Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: a multi-centred, placebo-controlled preliminary clinical trial
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep Med 12:906-13. 2011
    Intravenous (IV) iron has been used as a treatment to reduce Restless Legs Syndrome (RLS) symptoms, but two double-blinded trials of a frequently prescribed IV iron formulation, iron sucrose, failed to show lasting efficacy...
  58. ncbi Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms
    Leonard B Weinstock
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Sleep Med Rev 16:341-54. 2012
    Theories for restless legs syndrome (RLS) pathogenesis include iron deficiency, dopamine dysregulation and peripheral neuropathy...
  59. ncbi Prevalence of restless legs syndrome in North American and Western European populations: a systematic review
    Kim E Innes
    Department of Community Medicine, West Virginia University School of Medicine, P O Box 9190, Morgantown, WV 26506 9190, USA
    Sleep Med 12:623-34. 2011
    b>Restless legs syndrome (RLS) is a potentially debilitating sleep disorder that affects a significant percentage of North American and European adults...
  60. ncbi Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States
    Wayne A Hening
    Department of Neurology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Mov Disord 25:1675-83. 2010
    ..assessed efficacy and safety of the dopamine agonist rotigotine in the treatment of idiopathic restless legs syndrome (RLS) over a 6-month maintenance period...
  61. ncbi Absence of cardiovascular disease risk factors in restless legs syndrome
    F I I Cosentino
    Department of Neurology I C, Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy
    Acta Neurol Scand 125:319-25. 2012
    b>Restless legs syndrome (RLS) might represent a condition at risk of cardiovascular (and cerebrovascular) disease; the role of sleep periodic leg movements, sleep deprivation, and presence of common risk factors for heart disease in these ..
  62. ncbi Differential diagnosis of unpleasant sensations in the legs: prevalence of restless legs syndrome in a primary care population
    Caroline Möller
    Department of Neurology, J W Goethe University, Frankfurt am Main, Germany Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    Sleep Med 11:161-6. 2010
    b>Restless legs syndrome (RLS) is a common neurological condition. We investigated the prevalence of RLS in patients suffering from unpleasant sensations in the legs.
  63. ncbi Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
    Juliane Winkelmann
    Institute of Human Genetics, GSF National Research Center of Environment and Health, D 85764 Neuherberg, Munich, Germany
    Nat Genet 39:1000-6. 2007
    b>Restless legs syndrome (RLS) is a frequent neurological disorder characterized by an imperative urge to move the legs during night, unpleasant sensation in the lower limbs, disturbed sleep and increased cardiovascular morbidity...
  64. ncbi Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome
    M Manconi
    Sleep and Epilepsy Centre, Neurocenter EOC of Southern Switzerland, Ospedale Civico, Lugano, Switzerland
    Neurology 77:110-7. 2011
    ..and the D3 preferential agonist pramipexole was performed in order to understand which dopamine agonist receptor subtype plays the main role in the treatment of restless legs syndrome (RLS) with periodic leg movements during sleep (PLMS).
  65. ncbi Restless legs syndrome, periodic limb movements in sleep, and depression
    Daniel Picchietti
    Sleep Disorders Center, Carle Clinic Association and University of Illinois School of Medicine, 602 W University Avenue, Urbana, IL 61801, USA
    Sleep 28:891-8. 2005
    To review the literature on restless legs syndrome (RLS), periodic limb movements in sleep, and depression.
  66. pmc Prospective study of restless legs syndrome and mortality among men
    Yanping Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Neurology 81:52-9. 2013
    To prospectively examine whether men with restless legs syndrome (RLS) had an increased risk of mortality.
  67. pmc Migraine and restless legs syndrome in women
    Markus Schürks
    Brigham and Women s Hospital, Boston, MA, USA
    Cephalalgia 32:382-9. 2012
    Few clinic-based studies report an association between migraine and restless legs syndrome (RLS); however, population-based data are unavailable.
  68. ncbi Serum 25-hydroxyvitamin D levels in restless legs syndrome patients
    Hatice Balaban
    Department of Neurology, Cumhuriyet University, Faculty of Medicine, TR 58140 Sivas, Turkey
    Sleep Med 13:953-7. 2012
    b>Restless legs syndrome is characterised by discomfort during rest and an urge to move the limbs that is accompanied by abnormal sensations. Studies on disease pathophysiology have focused on dopaminergic dysfunction...
  69. pmc Elevated C-reactive protein is associated with severe periodic leg movements of sleep in patients with restless legs syndrome
    Lynn Marie Trotti
    Emory Program in Sleep, Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Brain Behav Immun 26:1239-43. 2012
    b>Restless legs syndrome (RLS) is a common sleep disorder in which urges to move the legs are felt during rest, are felt at night, and are improved by leg movement. RLS has been implicated in the development of cardiovascular disease...
  70. ncbi Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome
    Arthur S Walters
    New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08818, USA
    Sleep Med 4:121-32. 2003
    There is a need for an easily administered instrument which can be applied to all patients with restless legs syndrome (RLS) to measure disease severity for clinical assessment, research, or therapeutic trials...
  71. ncbi The prevalence of restless legs syndrome in Taiwanese adults
    Ning Hung Chen
    Sleep Center, Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taiwan
    Psychiatry Clin Neurosci 64:170-8. 2010
    Few studies have examined the prevalence of restless legs syndrome (RLS) in Asian populations, with existing data suggesting substantially lower rates of RLS in Asian populations compared with Caucasians...
  72. ncbi Pathophysiological concepts of restless legs syndrome
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 22:1451-6. 2007
    Pathophysiological concepts of restless legs syndrome (RLS) are based mainly on neuroimaging and on neurophysiological data...
  73. ncbi Oxidative stress and autonomic nervous system functions in restless legs syndrome
    Mehmet Ali Cikrikcioglu
    Internal Medicine Clinic, Vakif Gureba Training and Research Hospital, Fatih, Istanbul, Turkey
    Eur J Clin Invest 41:734-42. 2011
    Oxidative stress has been implicated in over 100 disorders in recent years; however, the situation in restless legs syndrome (RLS) has not been studied yet.
  74. ncbi Restless legs syndrome-associated MEIS1 risk variant influences iron homeostasis
    Hélène Catoire
    Centre of Excellence in Neuromics, CHUM Research Centre, University of Montreal, Montreal, Quebec, Canada
    Ann Neurol 70:170-5. 2011
    b>Restless legs syndrome (RLS) is a frequent sleep disorder that is linked to disturbed iron homeostasis...
  75. ncbi Randomized polysomnography study of gabapentin enacarbil in subjects with restless legs syndrome
    John W Winkelman
    Brigham and Women s Hospital Sleep Health Center, Brighton, Massachusetts, USA
    Mov Disord 26:2065-72. 2011
    ..the efficacy and tolerability of gabapentin enacarbil in the treatment of moderate to severe primary restless legs syndrome and associated sleep disturbance...
  76. ncbi Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis: a pilot study
    Giorgos K Sakkas
    Department of Nephrology, School of Medicine, University of Thessaly, Greece
    ASAIO J 54:185-90. 2008
    We present the first study on the influence of exercise training on restless legs syndrome (RLS) in patients on hemodialysis (HD)...
  77. ncbi Restless Legs Syndrome among working-aged women
    J Ulfberg
    Department of Medical Sciences Occupational and Environmental Medicine, University Hospital, S 751 85 Uppsala, Sweden
    Eur Neurol 46:17-9. 2001
    ..Standardized diagnostic criteria determined by the International Restless Legs Syndrome Study Group were used to investigate the prevalence of restless legs syndrome (RLS)...
  78. pmc Correlation of anxiety and depression symptoms in patients with restless legs syndrome: a population based survey
    S Sevim
    Department of Neurology, Mersin University, Faculty of Medicine, Mersin, Turkey
    J Neurol Neurosurg Psychiatry 75:226-30. 2004
    b>Restless legs syndrome (RLS) is an important and common cause of insomnia, and previous studies indicate that psychiatric wellbeing may be impaired among RLS patients...
  79. ncbi A 52-week study of gabapentin enacarbil in restless legs syndrome
    Aaron L Ellenbogen
    Quest Research Institute, Farmington Hills, MI 48334, USA
    Clin Neuropharmacol 34:8-16. 2011
    This open-label, multicenter, 52-week extension study (NCT00333359) assessed the long-term safety and efficacy of gabapentin enacarbil in subjects with moderate-to-severe primary restless legs syndrome (RLS).
  80. ncbi Levodopa for idiopathic restless legs syndrome: evidence-based review
    Cristiane Fiquene Conti
    Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
    Mov Disord 22:1943-51. 2007
    b>Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other ..
  81. ncbi European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society
    Diego Garcia-Borreguero
    Sleep Research Institute, Madrid, Spain
    Eur J Neurol 19:1385-96. 2012
    ..of the first European Federation of Neurological Societies (EFNS) guidelines in 2005 on the management of restless legs syndrome (RLS; also known as Willis-Ekbom disease), there have been major therapeutic advances in the field...
  82. ncbi Sonographic abnormalities in idiopathic restless legs syndrome (RLS) and RLS in Parkinson's disease
    Jung Ho Ryu
    Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, 761 1, Sanggye 7 dong, No won Gu, Seoul 139 707, Republic of Korea
    Parkinsonism Relat Disord 17:201-3. 2011
    ..investigate and compare sonographic abnormalities in the substantia nigra (SN) in patients with idiopathic restless legs syndrome (iRLS), those with RLS and Parkinson's disease (RLS-PD), those with idiopathic Parkinson's disease (iPD), ..
  83. ncbi Prevalence and disease burden of primary restless legs syndrome: results of a general population survey in the United States
    Richard P Allen
    Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
    Mov Disord 26:114-20. 2011
    To assess prevalence, disease burden, and costs of primary Restless Legs Syndrome (RLS) in the US...
  84. ncbi Ropinirole improves depressive symptoms and restless legs syndrome severity in RLS patients: a multicentre, randomized, placebo-controlled study
    Heike Benes
    Somni Bene Institute for Medical Research and Sleep Medicine, Schwerin, Germany
    J Neurol 258:1046-54. 2011
    Comorbid depressive symptoms in restless legs syndrome (RLS) remain a treatment challenge, as some antidepressants aggravate RLS symptoms. Preliminary data in depressive patients suggest antidepressant properties of ropinirole...
  85. ncbi Prevalence and clinical profile of restless legs syndrome in Parkinson's disease
    Dagmar Verbaan
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Mov Disord 25:2142-7. 2010
    Parkinson's disease (PD) and restless legs syndrome (RLS) have a dopaminergic link. More insight in the clinical profile of RLS in patients with PD may benefit our understanding of this link...
  86. ncbi Restless legs syndrome is common among female patients with fibromyalgia
    Romana Stehlik
    Sleep Disorders Center, Avesta Hospital, Avesta, Sweden
    Eur Neurol 61:107-11. 2009
    The prevalence of restless legs syndrome (RLS) among the general population is 2-15%, and with fibromyalgia syndrome (FMS) 2%. Both RLS and FMS are more common among women...
  87. pmc Long-term maintenance treatment of restless legs syndrome with gabapentin enacarbil: a randomized controlled study
    Richard K Bogan
    SleepMed, Columbia, SC 2920, USA
    Mayo Clin Proc 85:512-21. 2010
    To assess maintenance of efficacy and tolerability of gabapentin enacarbil in patients with moderate to severe primary restless legs syndrome (RLS).
  88. ncbi Changes of cortical excitability after dopaminergic treatment in restless legs syndrome
    Anna Scalise
    Department of Neurosciences, S Maria della Misericordia University Hospital, Udine, Italy
    Sleep Med 11:75-81. 2010
    Dopaminergic pathways are most likely involved in the pathophysiology of restless legs syndrome (RLS). In previous investigations, an alteration of cortical excitability was suggested to be related to a dopaminergic dysfunction in RLS...
  89. pmc Epidemiology of restless legs syndrome: a synthesis of the literature
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, Stanford University, School of Medicine, 3430 West Bayshore Road, Palo Alto, CA 94303, USA
    Sleep Med Rev 16:283-95. 2012
    b>Restless legs syndrome (RLS) has gained considerable attention in the recent years: nearly 50 community-based studies have been published in the last decade around the world...
  90. ncbi Restless legs syndrome: pathophysiology, clinical presentation and management
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Center of Parkinsonism and Movement Disorders, Klinikstrasse 16, 34128 Kassel, Germany
    Nat Rev Neurol 6:337-46. 2010
    b>Restless legs syndrome (RLS) is a somatosensory network disorder that is clinically diagnosed according to four main criteria: an urge to move the legs, usually associated with unpleasant leg sensations; induction or exacerbation of ..
  91. ncbi Efficacy and safety of dopamine agonists in restless legs syndrome
    Magdolna Hornyak
    Interdisciplinary Pain Centre, University Medical Centre, Breisacher Strasse 64, 79106 Freiburg, Germany
    Sleep Med 13:228-36. 2012
    b>Restless legs syndrome (RLS) is a common neurological disorder causing considerable impairment to daily living...
  92. ncbi Economic and human costs of restless legs syndrome
    Thomas Reinhold
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    Pharmacoeconomics 27:267-79. 2009
    b>Restless legs syndrome (RLS) is a common and often underestimated neurological disorder, with a prevalence ranging from approximately 2.5% to 10% in Western industrialized countries...
  93. ncbi Rotigotine transdermal patch for the treatment of Parkinson's disease and restless legs syndrome
    B Boroojerdi
    Schwarz BioSciences GmbH, UCB Pharma Group, Monheim, Germany
    Drugs Today (Barc) 46:483-505. 2010
    ..Clinical trials have demonstrated that rotigotine is efficacious as monotherapy for PD and restless legs syndrome (RLS), and open-label extension studies have shown its long-term efficacy...
  94. ncbi Comparative placebo-controlled polysomnographic and psychometric studies on the acute effects of gabapentin versus ropinirole in restless legs syndrome
    Michael Saletu
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    J Neural Transm 117:463-73. 2010
    ..sleep laboratory study was to compare the acute effects of gabapentin (GBT) and ropinirole (ROP) in restless legs syndrome (RLS). In a parallel-group design, 40 RLS patients received 300 mg GBT and another 40 patients 0...
  95. ncbi Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Med 120:S13-21. 2007
    b>Restless legs syndrome (RLS) can occur as a primary disorder, with no apparent cause other than a possible genetic predisposition, or as a secondary condition, most commonly related to iron deficiency, pregnancy, or end-stage renal ..
  96. ncbi Exercise and restless legs syndrome: a randomized controlled trial
    Melissa McManama Aukerman
    Department of Kinesiology, Pennsylvania State University, Pennsylvania, USA
    J Am Board Fam Med 19:487-93. 2006
    b>Restless legs syndrome (RLS) is a common, underdiagnosed neurological movement disorder of undetermined etiology. The primary treatments for restless legs syndrome are pharmacological...
  97. pmc Frequency of impulse control behaviours associated with dopaminergic therapy in restless legs syndrome
    Valerie Voon
    Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    BMC Neurol 11:117. 2011
    Low doses of dopamine agonists (DA) and levodopa are effective in the treatment of restless legs syndrome (RLS)...
  98. ncbi Health-related quality of life and restless legs syndrome among women in Sweden
    Jan Wesström
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Psychiatry Clin Neurosci 64:574-9. 2010
    b>Restless legs syndrome (RLS) is a common neurological movement disorder with a female preponderance, an increasing prevalence with age and comorbidity...
  99. ncbi Association of restless legs syndrome with nocturnal eating: a case-control study
    Federica Provini
    Department of Neurological Sciences, University of Bologna, Via Ugo Foscolo 7, Bologna, Italy
    Mov Disord 24:871-7. 2009
    ..of nocturnal eating (sleep-related eating disorder-SRED or night-eating syndrome-NES) in patients with restless legs syndrome (RLS)...
  100. ncbi Epidemiology of restless legs syndrome in French adults: a nationwide survey: the INSTANT Study
    F Tison
    Hopital Haut Leveque, Pessac, France
    Neurology 65:239-46. 2005
    To evaluate the prevalence, characteristics, and treatment of restless legs syndrome (RLS) in France.
  101. ncbi Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron
    K A Lee
    Department of Family Health Care Nursing, University of California San Francisco, San Francisco, California 94143-0606, USA
    J Womens Health Gend Based Med 10:335-41. 2001
    b>Restless legs syndrome (RLS) is a neurosensory disorder that typically begins in the evening and often prevents a person from falling asleep...

Research Grants63

  1. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Restless legs syndrome (RLS) is a chronic sleep motor disorder characterized by unpleasant sensations in the legs and an uncontrollable urge to move them for relief...
  2. Prospective Study of Restless Leg Syndrome
    Xiang Gao; Fiscal Year: 2011
    DESCRIPTION (provided by principal investigator): The restless legs syndrome (RLS) is a common movement disorder, characterized by an almost irresistible urge to move the legs...
  3. Restless Legs Syndrome, Cardiovascular Risk Factors, and Cardiovascular Events
    Tobias Kurth; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This is a resubmission of grant proposal R01 HL091880-01, "Restless Legs Syndrome, Cardiovascular Risk Factors, and Cardiovascular Disease...
  4. COGNITIVE BENEFITS OF TREATING SLEEP APNEA IN DEMENTIA
    Sonia Ancoli-Israel; Fiscal Year: 2011
    ..include examining the relationship between SDB and other sleep disorders such as REM behavior disorder and restless legs syndrome and whether treatment of SDB will ameliorate the symptoms of these other sleep disorders...
  5. Mechanisms and Regulation of Brain Iron Uptake
    Ian A Simpson; Fiscal Year: 2013
    ..studies on human microvasculature such as our recent findings in the microvasculature of individuals with Restless Legs syndrome or the long-term changes in CSF protein profiles associated with iron deficiency despite the resolution of ..
  6. The Control of Active (REM) Sleep by the Amygdala
    Michael H Chase; Fiscal Year: 2012
    ..for the treatment of disorders of active sleep including REM Behavior Disorder, narcolepsy/cataplexy, and Restless Legs Syndrome. This knowledge will also provide a key foundation for a comprehensive approach to translational research ..
  7. Glutamate, hyperarousal and restless legs syndrome
    RICHARD PUTNAM ALLEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Moderate to severe Restless Legs Syndrome (RLS) is a major public health problem, significantly affecting 1...
  8. Restless Legs Syndrome- The Iron-Dopamine Connection
    Christopher Earley; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): We have proposed the following Core Concept for this project: Restless Legs Syndrome (RLS) symptoms result from altered dopaminergic mechanisms that are precipitated by a relative or absolute ..
  9. Validation of Measures of Restless Legs Syndrome for Elders with Memory Disorders
    Kathy Richards; Fiscal Year: 2009
    ..purpose of this research is to identify a valid objective method to diagnose a prevalent sleep disorder, restless legs syndrome (RLS), in elders with dementia...
  10. Ventral Mesopontine Junction and Motor Activity
    Yuan Yang Lai; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Restless legs syndrome (RLS) and periodic leg movements disorder (PLMD) are present in 5 percent and 11 percent of the population, respectively and can cause a severe sleep disruption; however, no ..
  11. Circadian Regulation of Dopaminergic Activity and Restless Legs Syndrome
    Colleen McClung; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Restless legs syndrome (RLS) is a common neurological disorder affecting up to 20% of the population. RLS sufferers describe unpleasant and painful sensations in the legs and the intense urge to move...
  12. Hypocretin, Histamine and the Restless Legs Syndrome
    Richard Allen; Fiscal Year: 2004
    b>Restless Legs Syndrome (RLS) is a common sensory-motor disorders whose symptoms predominant at night and often lead to significant sleep loss and changes in one's quality of life...
  13. The use of valerian on sleep in persons with restless legs syndrome
    Norma Cuellar; Fiscal Year: 2009
    ..b>Restless Legs Syndrome (RLS) is a common sleep disorder affecting up to 15% of the population, especially in older adults...
  14. PERIODIC LIMB MOVEMENTS IN WILLIAMS SYNDROME
    Thornton Mason; Fiscal Year: 2006
    ..Although family studies suggest a genetic basis for some cases of PLMS occurring with restless legs syndrome, no associated genes or gene products have been identified...
  15. Restless Legs Syndrome Scientific Meeting
    Christopher Earley; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): It was on February 22, 1997 that the first Restless legs syndrome (RLS) Scientific Meeting was held at the National Academy of Sciences in Washington D.C...
  16. Ambulatory Assessment of Leg Movements and Arousals
    DAVID KRAUSMAN; Fiscal Year: 2004
    ..The Restless Legs Syndrome (RLS) is a common sensory-motor disorder associate with profound insomnia and in population studies has ..
  17. DOPAMINERGIC CONTROL OF SPINAL CORD AND RESTLESS LEGS
    Shawn Hochman; Fiscal Year: 2006
    b>Restless legs syndrome (RLS) is a CNS disorder involving abnormal muscle sensations that are reduced during motor activity, worsen at rest, and have a marked circadian pattern...
  18. Study of L-Dopa in ADHD and RLS/PLMS
    Arthur Walters; Fiscal Year: 2004
    ..trial of levodopa in children with ADHD both with and without periodic limb movements of sleep (PLMS) and restless legs syndrome (RLS)...
  19. Human Imaging Research in Neuropsychiatry and Drug Abuse
    DEAN WONG; Fiscal Year: 2009
    ..research from drug development and cocaine craving to also include alcoholism, Tourette Syndrome and Restless Legs Syndrome. I obtained a second NCRR funded Shared Instrumentation Grant for the HRRT (high resolution research ..
  20. DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2003
    b>Restless Legs Syndrome (RLS) is a common sleep disorder especially for older adults. It is characterized by episodes of distressing sensations in the limbs, generally the legs, which are relieved by movement of the affected extremity...
  21. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Restless Legs Syndrome (RLS) is a common sensory-motor disorder whose symptoms predominans Legs Syndrome (RLS) is a common sensory-motor disorder whose symptoms predominant at night and often lead to ..
  22. DOPAMINERGIC FUNCTION IN RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2001
    ..application for three years of funding to investigate the role of iron and dopamine in pathophysiology of restless legs syndrome (RLS), a common sleep disorder, especially for older patients...
  23. Response to Iron Treatment for Restless Leg Syndrome
    Christopher Earley; Fiscal Year: 2004
    b>Restless Legs Syndrome (RLS) is a common, dopamine- responsive, sensory-motor disorder whose symptoms predominant at night and often lead to significant sleep loss and changes in one's quality of life...
  24. Restless Legs Syndrome Sensory Symptoms During Home-based Self-imposed Rest
    GUSTAVO AGUIRRE; Fiscal Year: 2008
    Project Summary/Abstract The neurological and sleep-related sensory disorder called Restless Legs Syndrome (RLS) occurs with moderate to severe intensity in 2 [unreadable] 3% of the population of the United States...
  25. Sleep/Wake Contiuum in Lewy Body Disease
    Donald L Bliwise; Fiscal Year: 2010
    ..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
  26. Biomarkers of Aging in the Bay Area Sleep Cohort
    Donald Bliwise; Fiscal Year: 2005
    ..abstract_text> ..
  27. SUNDOWN SYNDROME IN A SKILLED NURSING FACILITY
    Donald Bliwise; Fiscal Year: 2002
    ..These results will provide information on the mechanistic basis for sundowning in aged patients with dementing disorders. ..
  28. Polysomnographic Assessment of Alternative Treatment
    Donald Bliwise; Fiscal Year: 2006
    ..abstract_text> ..
  29. BRAINSTEM SUBSTRATES OF DOPAMINE MODULATED MOVEMENTS
    David Rye; Fiscal Year: 2002
    ..g., OCD, ADD, Tourette's and schizophrenia, the results will also bear relevance to a wider spectrum of disease. ..
  30. SLEEP/DOPAMINE PHENOTYPES IN GENETICALLY DISTINCT MICE
    David Rye; Fiscal Year: 2002
    ..abstract_text> ..
  31. Isolation and Characterization of a Ferritin Receptor
    James Connor; Fiscal Year: 2005
    ..This project will significantly alter our thinking on brain iron transport and open novel directions for research in oligodendrocyte biology and diagnositic and therapeutic strategies in demyelinating disorders ..
  32. Translocation and Function of Nuclear Ferritin
    James Connor; Fiscal Year: 2004
    ..abstract_text> ..
  33. Circuitry of Midbrain Dopamine in Sleep & Wake
    David Rye; Fiscal Year: 2005
    ..g., schizophrenia) and hypodopaminergic (e.g., PD and restless legs/periodic leg movements of sleep). ..
  34. Iron Acquisition Mechanisms in Oligodendrocytes
    JAMES ROBERT CONNOR; Fiscal Year: 2010
    ..abstract_text> ..
  35. Spectrum of Narcolepsy in the Probands Families
    MAURICE OHAYON; Fiscal Year: 2007
    ..A blood sample (3-5 ml) will be asked also to all participants. This will allow us to link some genetic markers of narcolepsy to specific symptoms even in subjects without the full-fledge manifestation of the disease. ..
  36. Implementation of Asthma Guidelines in Primary Care; Comparison of 4 approaches
    James W Mold; Fiscal Year: 2010
    ..If effective, the same strategies could be used to facilitate implementation of other chronic disease guidelines. ..
  37. Cognitive Sequelae of early and mid-life depression
    Hochang Lee; Fiscal Year: 2008
    ..This award will provide groundwork for his long term goal of becoming an expert in clinical epidemiology of late life mental disorders. ..
  38. Restless Legs risk in the biracial East Baltimore cohort
    Hochang Lee; Fiscal Year: 2006
    The major goal of this study is to determine the relationship of the Restless Legs Syndrome (RLS) to potential risk factors: ethnicity and both physical and mental health...
  39. fMRI of CBT and CM for Cocaine Dependence
    MARC POTENZA; Fiscal Year: 2009
    ..Successful completion of this project would lay the foundation for future studies (e.g., those combining behavioral and pharmacological treatments) in cocaine dependence and other addictive disorders. ..
  40. Mechanisms of Sleep-Disordered Breathing in the Menopausal Transition
    Grace W Pien; Fiscal Year: 2010
    ..These findings will allow us to identify women at risk for sleep-disordered breathing after menopause and to focus on tailoring treatments in this area. ..
  41. Disrupted Sleep in the Elderly: Circadian Etiology
    JEANNE DUFFY; Fiscal Year: 2009
    ....
  42. Sleep-Health & Knowledge in U.S. Hispanics
    JOSE LOREDO; Fiscal Year: 2009
    ..S. Mexican-American Hispanics should include intensive focus on Sleep Health and Sleep Health knowledge deficits. Key Words: Sleep disorders;Minority health;Epidemiology. ..
  43. fMRI of Craving in Addictions: Gender Differences
    MARC POTENZA; Fiscal Year: 2009
    ..abstract_text> ..
  44. Sleep Neuroscience in Depression
    Eric Nofzinger; Fiscal Year: 2009
    ..Multiple linear regressions will be used to test the mediational models above. Findings from this study are expected to significantly advance our understanding of the neuroscience of depression. ..
  45. PUPILLOMETRIC SLEEPINESS IN TREATED SLEEP DISORDERS
    Joan Shaver; Fiscal Year: 2003
    ..Results will provide evidence about the PUI as a reliable and valid objective outcome measure of waking tendency among controls, and pre-post-treatment for OSA and narcolepsy subjects. ..
  46. Dedicated High Performance Human Brain/Preclinical PET
    DEAN WONG; Fiscal Year: 2004
    ..abstract_text> ..
  47. FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCER
    Sonia Ancoli Israel; Fiscal Year: 2004
    ..Results will provide a scientific basis for future intervention studies, particularly studies with light therapy which can re-synchronize rhythms. ..
  48. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
  49. EPIDEMIOLOGY AND GENETICS OF PARKINSON'S DISEASE
    Walter Rocca; Fiscal Year: 2005
    ..These three studies will contribute greatly to understanding the causes and possible prevention of PD by exploring novel hypotheses and by using innovative methods. ..
  50. HUMAN AXONAL REGENERATION IN DIABETIC NEUROPATHY
    Michael Polydefkis; Fiscal Year: 2005
    ..Polydefkis the skills he needs to develop into an independent clinician researcher in the field of peripheral nerve disease. ..
  51. Preventing Risks of Long Sleep
    SHAWN YOUNGSTEDT; Fiscal Year: 2005
    ..Benefits and risks will be assessed by examining changes in sleepiness, depression, quality-of-life, neurobehavioral performance, glucose tolerance, and actigraphic and subjective sleep. ..
  52. Longitudinal Study--Sleep-Disordered Breathing/Pregnancy
    Grace Pien; Fiscal Year: 2006
    ....
  53. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
  54. BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICE
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  55. Effect of Vitamin B12 on the Human Circadian Pacemaker
    JEANNE DUFFY; Fiscal Year: 2007
    ..abstract_text> ..
  56. The Effects of Hemodialysis on the Sleep/Wake Cycle
    Kathy Parker; Fiscal Year: 2007
    ..In addition, study results will make a significant contribution to the scientific understanding of how medical treatments may interact with normal systems to induce sleep/wake abnormalities. ..
  57. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  58. Classifying Psychiatric, Medical, and Primary Insomnias
    Jack Edinger; Fiscal Year: 2007
    ..This project will provide a much-needed comparison of these two insomnia nosologies and the subtypes they define. Results also likely will provide important information for future insomnia classification efforts. ..
  59. Family Linkage Study of Obstructive Sleep Apnea
    Allan Pack; Fiscal Year: 2007
    ..abstract_text> ..
  60. Cytokine Gene Polymorphisms in Acute Renal Failure
    Bertrand Jaber; Fiscal Year: 2007
    ..The proposed training program and research project will prepare him for a career as an independent investigator. ..
  61. CASE CONTROL STUDY OF INSOMNIA IN NONDEPRESSED ELDERLY
    Allan Pack; Fiscal Year: 2001
    ....