sleep initiation and maintenance disorders

Summary

Summary: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.

Top Publications

  1. ncbi Epidemiology of insomnia: what we know and what we still need to learn
    Maurice M Ohayon
    Sleep Disorders Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Sleep Med Rev 6:97-111. 2002
  2. ncbi Mortality associated with sleep duration and insomnia
    Daniel F Kripke
    Department of Psychiatry 0667, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0667, USA
    Arch Gen Psychiatry 59:131-6. 2002
  3. ncbi Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies
    Chiara Baglioni
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Hauptstrasse 5, 79104 Freiburg, Germany
    J Affect Disord 135:10-9. 2011
  4. ncbi Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group
    Jack D Edinger
    VA Medical Center, Durham, NC, USA
    Sleep 27:1567-96. 2004
  5. pmc Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
    Jennifer Glass
    University of Toronto, Department of Pharmaceutical Sciences, Toronto, ON, Canada M5S 2S2
    BMJ 331:1169. 2005
  6. ncbi Athens Insomnia Scale: validation of an instrument based on ICD-10 criteria
    C R Soldatos
    Sleep Research Unit, Department of Psychiatry, Athens University Medical School, Athens, Greece
    J Psychosom Res 48:555-60. 2000
  7. ncbi Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors
    C M Morin
    Ecole de Psychologie, Universite Laval, and Centre de recherche du CHA Hôpital du Saint Sacrement, Quebec City, Quebec, Canada
    Sleep Med 7:123-30. 2006
  8. ncbi Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia
    Jutta Backhaus
    Department of Psychiatry and Psychotherapy, University Hospital of Luebeck, Luebeck, Germany
    J Psychosom Res 53:737-40. 2002
  9. ncbi Wrist actigraphy in insomnia
    P J Hauri
    Mayo Sleep Disorders Center, Mayo Clinic, Rochester, MN 55905
    Sleep 15:293-301. 1992
  10. ncbi Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) in psychiatric disordered and control subjects
    Y Doi
    Department of Epidemiology, National Institute of Public Health, 4 6 1 Shirokanedai Minato ku, Tokyo 108 8638, Japan
    Psychiatry Res 97:165-72. 2000

Detail Information

Publications352 found, 100 shown here

  1. ncbi Epidemiology of insomnia: what we know and what we still need to learn
    Maurice M Ohayon
    Sleep Disorders Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Sleep Med Rev 6:97-111. 2002
    ..Future epidemiological studies should focus on the natural evolution of insomnia. Epidemiological genetic links of insomnia are yet to be studied...
  2. ncbi Mortality associated with sleep duration and insomnia
    Daniel F Kripke
    Department of Psychiatry 0667, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0667, USA
    Arch Gen Psychiatry 59:131-6. 2002
    ..Treatment strategies may be guided by what sleep durations predict optimal survival and whether insomnia might signal mortality risks...
  3. ncbi Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies
    Chiara Baglioni
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Hauptstrasse 5, 79104 Freiburg, Germany
    J Affect Disord 135:10-9. 2011
    ..This meta-analysis is aimed at evaluating quantitatively if insomnia constitutes a predictor of depression...
  4. ncbi Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group
    Jack D Edinger
    VA Medical Center, Durham, NC, USA
    Sleep 27:1567-96. 2004
    ..This report outlines the WG's findings, the insomnia RDC derived, and research assessment procedures the WG recommends for identifying study participants who meet these RDC...
  5. pmc Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
    Jennifer Glass
    University of Toronto, Department of Pharmaceutical Sciences, Toronto, ON, Canada M5S 2S2
    BMJ 331:1169. 2005
    ..To quantify and compare potential benefits (subjective reports of sleep variables) and risks (adverse events and morning-after psychomotor impairment) of short term treatment with sedative hypnotics in older people with insomnia...
  6. ncbi Athens Insomnia Scale: validation of an instrument based on ICD-10 criteria
    C R Soldatos
    Sleep Research Unit, Department of Psychiatry, Athens University Medical School, Athens, Greece
    J Psychosom Res 48:555-60. 2000
    ..To describe and validate the Athens Insomnia Scale (AIS)...
  7. ncbi Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors
    C M Morin
    Ecole de Psychologie, Universite Laval, and Centre de recherche du CHA Hôpital du Saint Sacrement, Quebec City, Quebec, Canada
    Sleep Med 7:123-30. 2006
    ..To estimate the prevalence of insomnia symptoms and syndrome in the general population, describe the types of self-help treatments and consultations initiated for insomnia, and examine help-seeking determinants...
  8. ncbi Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia
    Jutta Backhaus
    Department of Psychiatry and Psychotherapy, University Hospital of Luebeck, Luebeck, Germany
    J Psychosom Res 53:737-40. 2002
    ..Psychometric evaluation of the Pittsburgh Sleep Quality Index (PSQI) for primary insomnia...
  9. ncbi Wrist actigraphy in insomnia
    P J Hauri
    Mayo Sleep Disorders Center, Mayo Clinic, Rochester, MN 55905
    Sleep 15:293-301. 1992
    ..Based on our study, we now recommend actigraphy as an additional tool in the clinical evaluation of insomnia, but we believe that in complex cases it should be combined with 1 PSG night in the sleep disorders center...
  10. ncbi Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) in psychiatric disordered and control subjects
    Y Doi
    Department of Epidemiology, National Institute of Public Health, 4 6 1 Shirokanedai Minato ku, Tokyo 108 8638, Japan
    Psychiatry Res 97:165-72. 2000
    ..6% for generalized anxiety disorder, and 83.3 and 86.6% for schizophrenia, respectively. The present study supports the utility of the PSQI-J as a reliable and valid measure for subjective sleep quality in clinical practice and research...
  11. ncbi Insomnia and daytime cognitive performance: a meta-analysis
    Emilie Fortier-Brochu
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Sleep Med Rev 16:83-94. 2012
    ..This meta-analysis was conducted to provide a quantitative summary of evidence regarding the magnitude of differences between individuals with primary insomnia and normal sleepers on a broad range of neuropsychological measures...
  12. ncbi The hyperarousal model of insomnia: a review of the concept and its evidence
    Dieter Riemann
    Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Hauptstrasse 5, D 79104 Freiburg, Germany
    Sleep Med Rev 14:19-31. 2010
    ....
  13. ncbi Sleep-related memory consolidation in primary insomnia
    Christoph Nissen
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany
    J Sleep Res 20:129-36. 2011
    ..Future work is needed to investigate the impact of treatment on improving sleep and memory...
  14. ncbi Quantitative criteria for insomnia
    K L Lichstein
    Department of Psychology, University of Memphis, TN 38152 3230, USA
    Behav Res Ther 41:427-45. 2003
    ..We found that severity of sleep onset latency or wake time after sleep onset of: (a) > or =31 min; (b) occurring > or =3 nights a week; (c) for > or =6 months are the most defensible quantitative criteria for insomnia...
  15. ncbi Impaired declarative memory consolidation during sleep in patients with primary insomnia: Influence of sleep architecture and nocturnal cortisol release
    Jutta Backhaus
    Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany
    Biol Psychiatry 60:1324-30. 2006
    ..Here, we investigated whether the overnight consolidation of declarative memory in patients with chronic sleep disturbances is impaired, owing to less slow wave sleep (SWS) and an increased cortisol release...
  16. ncbi An epidemiological study of insomnia among the Japanese general population
    K Kim
    Department of Psychophysiology, National Institute of Mental Health, NCNP, Ichikawa-city, Chiba, Japan
    Sleep 23:41-7. 2000
    ..These findings indicate that the prevalence of insomnia in the general population of Japan is comparable to that reported in Western countries, and that insomnia is associated with multiple psychosocial factors...
  17. ncbi Hyperarousal and insomnia: state of the science
    Michael H Bonnet
    Dayton Department of Veterans Affairs Medical Center, Wright State University, Dayton, OH 45428, USA
    Sleep Med Rev 14:9-15. 2010
    ..It is hoped that these findings can be extended to identify new compounds that improve insomnia by acting at these sites of abnormal brain activation...
  18. pmc Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia
    Kathryn J Reid
    Department of Neurology, Northwestern University, Suite 500, Chicago, IL 60611, USA
    Sleep Med 11:934-40. 2010
    ..To assess the efficacy of moderate aerobic physical activity with sleep hygiene education to improve sleep, mood and quality of life in older adults with chronic insomnia...
  19. ncbi Insomnia and the risk of acute myocardial infarction: a population study
    Lars E Laugsand
    Department of Public Health, Faculty of Medicine, Trondheim, Norway
    Circulation 124:2073-81. 2011
    ..Few prospective studies have investigated insomnia in relation to risk for coronary heart disease. We assessed insomnia symptoms and risk of acute myocardial infarction (AMI) in a large, population-based study...
  20. ncbi Validation of the insomnia severity index as a web-based measure
    Frances P Thorndike
    Department of Psychiatry and Neurobehavioral Sciences Behavioral Health and Technology, University of Virginia Health System, Charlottesville, USA
    Behav Sleep Med 9:216-23. 2011
    ..26-.82). Together, findings suggest the ISI can be delivered online...
  21. pmc Insomnia symptoms in older adults: associated factors and gender differences
    Isabelle Jaussent
    INSERM, U888, Univ Montpellier 1, Montpellier, INSERM, U897, Univ Bordeaux 2, Bordeaux, France
    Am J Geriatr Psychiatry 19:88-97. 2011
    ..g., difficulty with initiating sleep (DIS), difficulty with maintaining sleep (DMS), and early morning awakening (EMA)...
  22. ncbi Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia
    Michael T Smith
    Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287 7218, USA
    Am J Psychiatry 159:5-11. 2002
    ..The authors conducted a quantitative review of the literature on the outcome of the two treatments to compare the short-term efficacy of pharmacotherapy and behavioral therapy in primary insomnia...
  23. pmc Cognitive behavioral therapy for insomnia enhances depression outcome in patients with comorbid major depressive disorder and insomnia
    Rachel Manber
    Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Rd, Stanford, CA 94305, USA
    Sleep 31:489-95. 2008
    ..This study is an initial evaluation of adding cognitive behavioral therapy for insomnia (CBTI) to the antidepressant medication escitalopram (EsCIT) in individuals with both disorders...
  24. ncbi Sleep complaints among elderly persons: an epidemiologic study of three communities
    D J Foley
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA
    Sleep 18:425-32. 1995
    ..Determining the prevalence of specific sleep disorders, independent of health status, will require the development of more sophisticated and objective measures of sleep disturbances...
  25. pmc Is insomnia a perpetuating factor for late-life depression in the IMPACT cohort?
    Wilfred R Pigeon
    Department of Psychiatry, University of Rochester Medical Center, Rochester NY, USA
    Sleep 31:481-8. 2008
    ..The present longitudinal study examines the relationship of insomnia to the continuation of depression in the context of an intervention study in elderly subjects...
  26. pmc Sleep loss activates cellular inflammatory signaling
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, CA 90095 7076, USA
    Biol Psychiatry 64:538-40. 2008
    ..This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade...
  27. ncbi Recommendations for a standard research assessment of insomnia
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Sleep 29:1155-73. 2006
    ..To present expert consensus recommendations for a standard set of research assessments in insomnia, reporting standards for these assessments, and recommendations for future research...
  28. ncbi Trends in self-reported sleep duration and insomnia-related symptoms in Finland from 1972 to 2005: a comparative review and re-analysis of Finnish population samples
    Erkki Kronholm
    The National Public Health Institute, Turku, Finland
    J Sleep Res 17:54-62. 2008
    ..In conclusion, the Finnish data during the past 33 years indicate a general decrease in self-reported sleep duration of about 18 min and an increase of sleep complaints, especially among the employed middle-aged population...
  29. ncbi Psychological and behavioral treatment of insomnia:update of the recent evidence (1998-2004)
    Charles M Morin
    Universite Laval, Quebec, Canada
    Sleep 29:1398-414. 2006
    ..As with the original paper, this review was conducted by a task force commissioned by the American Academy of Sleep Medicine in order to update its practice parameters on psychological and behavioral therapies for insomnia...
  30. ncbi Epidemiology of insomnia, depression, and anxiety
    Daniel J Taylor
    University of North Texas, Department of Psychology, Denton 76203 1280, USA
    Sleep 28:1457-64. 2005
    ..All analyses controlled for health variables, demographics, organic sleep disorders, and symptoms of organic sleep disorders...
  31. ncbi Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:3787-94. 2001
    ..The therapeutic goal in insomnia should be to decrease the overall level of physiologic and emotional arousal, and not just to improve the nighttime sleep...
  32. ncbi The diagnostic validity of the Athens Insomnia Scale
    Constantin R Soldatos
    Sleep Research Unit, Department of Psychiatry, Athens University Medical School, Athens, Greece
    J Psychosom Res 55:263-7. 2003
    ....
  33. pmc Clinical guideline for the evaluation and management of chronic insomnia in adults
    Sharon Schutte-Rodin
    Penn Sleep Centers, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    J Clin Sleep Med 4:487-504. 2008
    ..Unless otherwise stated, "insomnia" refers to chronic insomnia, which is present for at least a month, as opposed to acute or transient insomnia, which may last days to weeks...
  34. ncbi Prevalence, burden, and treatment of insomnia in primary care
    G E Simon
    Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA 98101 1448, USA
    Am J Psychiatry 154:1417-23. 1997
    ..The prevalence, burden, and management of insomnia among primary care patients were evaluated...
  35. pmc Meta-analysis of benzodiazepine use in the treatment of insomnia
    A M Holbrook
    Centre for Evaluation of Medicines, St Joseph s Hospital, Hamilton, Ont
    CMAJ 162:225-33. 2000
    ..To systematically review the benefits and risks associated with the use of benzodiazepines to treat insomnia in adults...
  36. pmc The economic burden of insomnia: direct and indirect costs for individuals with insomnia syndrome, insomnia symptoms, and good sleepers
    Meagan Daley
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Sleep 32:55-64. 2009
    ..This study estimated from a societal perspective the direct and indirect costs of insomnia...
  37. pmc Insomnia with objective short sleep duration is associated with a high risk for hypertension
    Alexandros N Vgontzas
    Sleep Research and Treatment Center Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Sleep 32:491-7. 2009
    ..To examine the joint effect of insomnia and objective short sleep duration on hypertension risk...
  38. ncbi Major depression and insomnia in chronic pain
    Keith G Wilson
    Institute for Rehabilitation Research and Development, The Rehabilitation Center, Ottawa, Ontario, Canada
    Clin J Pain 18:77-83. 2002
    ..The goal of this study was to examine the combined impact of major depression and insomnia on individuals with chronic pain...
  39. ncbi Headache and sleep: examination of sleep patterns and complaints in a large clinical sample of migraineurs
    Leslie Kelman
    The Headache Center of Atlanta, GA 30342, USA
    Headache 45:904-10. 2005
    ..This study characterized sleep parameters and complaints in a large clinical sample of migraineurs and examined sleep complaints in relation to headache frequency and severity...
  40. pmc Incidence and risk factors of insomnia in a population-based sample
    Mélanie LeBlanc
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Sleep 32:1027-37. 2009
    ..This study estimated the incidence of insomnia and examined potential risk factors in a cohort of good sleepers followed over a one-year period...
  41. ncbi A new scale for measuring insomnia: the Bergen Insomnia Scale
    Stale Pallesen
    Faculty of Psychology, University of Bergen, Christiesgt 12, 5015 Bergen, Norway
    Percept Mot Skills 107:691-706. 2008
    ..It is one of very few insomnia scales which provide normative data for comparisons and which has been validated against subjective as well as polysomnographic data...
  42. pmc Insomnia and daytime sleepiness are risk factors for depressive symptoms in the elderly
    Isabelle Jaussent
    INSERM, U1061, Montpellier, F 34000 France
    Sleep 34:1103-10. 2011
    ..However, these associations have not been investigated in community-dwelling elderly taking into account insomnia symptoms, EDS, and sleep medication...
  43. pmc Discrepancy between subjective symptomatology and objective neuropsychological performance in insomnia
    Henry J Orff
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA, USA
    Sleep 30:1205-11. 2007
    ..The goals for the study were to assess (1) whether PIs differ from GSs on subjective and/or objective measures and (2) the extent to which subjective and objective measures provide discordant information...
  44. ncbi Investigation of sleep disturbance in chronic low back pain: an age- and gender-matched case-control study over a 7-night period
    Alexander T M van de Water
    School of Public Health, Physiotherapy and Population Science, Health Sciences Centre, University College Dublin, Dublin 4, Ireland
    Man Ther 16:550-6. 2011
    ..05). The findings provide some evidence to support self-reported sleep assessment as an outcome measure in CLBP research, while further research is needed to determine the validity of objective sleep measurement in this population...
  45. ncbi Acupuncture for treatment of insomnia in patients with traumatic brain injury: a pilot intervention study
    Felise S Zollman
    Departments of Physical Medicine and Rehabilitation and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Head Trauma Rehabil 27:135-42. 2012
    ..To assess the efficacy of acupuncture in treating insomnia in traumatic brain injury (TBI) survivors as compared to medication, to determine whether acupuncture has fewer cognitive and affective adverse effects than does medication...
  46. ncbi Searching for the daytime impairments of primary insomnia
    Julia A Shekleton
    School of Psychology, Psychiatry and Psychological Medicine, Monash University, Building 17, Clayton Campus, Victoria 3800, Australia
    Sleep Med Rev 14:47-60. 2010
    ....
  47. pmc Shift work disorder in nurses--assessment, prevalence and related health problems
    Elisabeth Flo
    Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway
    PLoS ONE 7:e33981. 2012
    ..This study investigates the prevalence of symptoms of shift work disorder in a sample of nurses, and its association to individual, health and work variables...
  48. pmc Autonomic activation in insomnia: the case for acupuncture
    Wei Huang
    Atlanta VA Medical Center, Atlanta, GA, USA
    J Clin Sleep Med 7:95-102. 2011
    ..Our review indicates the necessity for further research in the relationship between the effects of acupuncture on insomnia and autonomic regulation, which might guide better selective use of this treatment modality for insomnia...
  49. pmc Insomnia with objective short sleep duration and incident hypertension: the Penn State Cohort
    Julio Fernandez-Mendoza
    Sleep Research and Treatment Center, Pennylvania State University College of Medicine, Department of Psychiatry H073, 500 University Dr, Hershey, PA 17033, USA
    Hypertension 60:929-35. 2012
    ..Objective short sleep duration in insomnia may serve as a useful predictor of the biological severity of the disorder...
  50. pmc Pain sensitivity and modulation in primary insomnia
    M Haack
    Beth Israel Medical Deaconess Center and Harvard Medical School, Boston, MA, USA
    Eur J Pain 16:522-33. 2012
    ..This constant activation ultimately may result in a ceiling effect of pain-inhibitory efforts, as indicated by the inability of the system to adequately function during challenge...
  51. ncbi The long-term effect of insomnia on work disability: the HUNT-2 historical cohort study
    Børge Sivertsen
    Department of Clinical Psychology, University of Bergen, and Affective Disorder Section, Department of Psychiatry, Haukeland University Hospital, Bergen, Norway
    Am J Epidemiol 163:1018-24. 2006
    ..75, 95% confidence interval: 1.40, 2.20). This study suggests that insomnia should receive increased attention as a robust predictor of subsequent work disability...
  52. ncbi Insomnia and its relationship to health-care utilization, work absenteeism, productivity and accidents
    M Daley
    Ecole de Psychologie, Universite Laval, Quebec, Canada G1K 0A6
    Sleep Med 10:427-38. 2009
    ..To document and provide a micro analysis of the relationship between insomnia and health problems, health-care use, absenteeism, productivity and accidents...
  53. ncbi Reliability and validity of the Women's Health Initiative Insomnia Rating Scale
    Douglas W Levine
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Psychol Assess 15:137-48. 2003
    ..Results showed that differences in the objective indicators could be detected by the WHIIRS. Findings suggest that a between-group mean difference of approximately 0.50 of a standard deviation on the WHIIRS may be clinically meaningful...
  54. ncbi Adverse effects of temazepam in older adults with chronic insomnia
    Charles M Morin
    Universite Laval, Quebec, Canada
    Hum Psychopharmacol 18:75-82. 2003
    ..Benzodiazepine-hypnotics are frequently used for treating insomnia in older adults; however, there is little information about adverse effects associated with their usage over several weeks, particularly in this segment of the population...
  55. ncbi Skin temperature and sleep-onset latency: changes with age and insomnia
    Roy J E M Raymann
    Netherlands Institute for Neuroscience NIN, Meibergdreef 47, 1105 BA Amsterdam, Amsterdam, The Netherlands
    Physiol Behav 90:257-66. 2007
    ..The sensitivity of sleep propensity to foot warming changes with age and is attenuated in age-related insomnia...
  56. ncbi The natural history of insomnia: a population-based 3-year longitudinal study
    Charles M Morin
    Universite Laval, Ecole de Psychologie, Pavillon Félix Antoine Savard, Quebec City, QC G1K 0A6, Canada
    Arch Intern Med 169:447-53. 2009
    ..The extent to which episodes of insomnia will persist or remit over time is difficult to predict. We examined the natural history of insomnia and describe the most common trajectories over 3 years...
  57. ncbi The long-term effect of insomnia on primary headaches: a prospective population-based cohort study (HUNT-2 and HUNT-3)
    Siv S Odegård
    Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, MTFS, Trondheim, Norway
    Headache 51:570-80. 2011
    ..Few prospective studies have evaluated the relationship between insomnia and headache. We aimed to analyze the influence of insomnia at baseline on the risk for headache 11 years later...
  58. ncbi Treatment preference and patient satisfaction in chronic insomnia
    N Vincent
    Dept Of Clinical Health Psychology, University of Manitoba
    Sleep 24:411-7. 2001
    ..The purposes of this study were to examine treatment preference and satisfaction with group treatment in individual with chronic insomnia...
  59. pmc Work-related sleep disturbances and sickness absence in the Swedish working population, 1993-1999
    Hugo Westerlund
    Stress Research Institute, Stockholm University, Stockholm, Sweden
    Sleep 31:1169-77. 2008
    ..To examine secular trends in work-related sleep disturbances and their association with sickness absence in the Swedish working population...
  60. pmc The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response
    Charles M Morin
    Université Laval and Centre de recherche Université Laval Robert Giffard, Quebec, Canada
    Sleep 34:601-8. 2011
    ..This study examined psychometric indices of the Insomnia Severity Index (ISI) to detect cases of insomnia in a population-based sample and to evaluate treatment response in a clinical sample...
  61. ncbi Childhood adversities and quality of sleep in adulthood: A population-based study of 26,000 Finns
    Karoliina Koskenvuo
    Department of Public Health, University of Helsinki, P O Box 41, 00014 Helsinki, Finland
    Sleep Med 11:17-22. 2010
    ..To find out if childhood adversities predict poor sleep quality in working age...
  62. ncbi A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder
    U Koetter
    Max Zeller Sohne AG, CH 8590 Romanshorn, Switzerland
    Phytother Res 21:847-51. 2007
    ..The result underlined the plausibility for adding hops extract to the valerian extract...
  63. pmc Disturbed sleep and its relationship to alcohol use
    Michael D Stein
    Brown Medical School, Division of General Internal Medicine, Rhode Island Hospital, Providence, RI 02903, USA
    Subst Abus 26:1-13. 2005
    ..To review evidence of an association between disturbed sleep and alcohol use...
  64. ncbi Sleep pattern in medical students and residents
    Marzieh Nojomi
    Department of Community Medicine, School of Medicine, Iran University of Medical Sciences, Crossroads of Hemmat and Chamran Expressways, Tehran15875 6171, Iran
    Arch Iran Med 12:542-9. 2009
    ..The objective of this study was to determine the prevalence of sleep disorders in medical students and residents...
  65. ncbi Zolpidem: an update of its pharmacology, therapeutic efficacy and tolerability in the treatment of insomnia
    K J Holm
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 59:865-89. 2000
    ..In this respect, it was comparable or superior to flunitrazepam and flurazepam and comparable to other benzodiazepines in patients with insomnia. Zolpidem appears to have a low potential for abuse...
  66. ncbi Mindfulness meditation and cognitive behavioral therapy for insomnia: a naturalistic 12-month follow-up
    Jason C Ong
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Explore (NY) 5:30-6. 2009
    ....
  67. pmc Risk factors for incident chronic insomnia: a general population prospective study
    Ravi Singareddy
    Sleep Research and Treatment Center, Penn State University College of Medicine, Hershey, PA, United States
    Sleep Med 13:346-53. 2012
    ..We prospectively examined the associations between demographics, behavioral factors, psychiatric and medical disorders, and polysomnography with incident chronic insomnia...
  68. ncbi Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials
    Maria Isabel Fernández-San-Martín
    Servicio de Atención Primaria Litoral, Institut Català de Salut, Barcelona, Spain
    Sleep Med 11:505-11. 2010
    ..Valerian might be an alternative treatment with fewer secondary effects. The aim of this study is to evaluate its effectiveness on insomnia through a meta-analysis of published literature...
  69. ncbi Safe enough to sleep: sleep disruptions associated with trauma, posttraumatic stress, and anxiety in children and adolescents
    Anthony Charuvastra
    Department of Child and Adolescent Psychiatry, Institute for Trauma and Resilience, The Trauma and Resilience Program, NYU Child Study Center, 16th Floor, 215 Lexington Avenue, New York, NY 10016, USA
    Child Adolesc Psychiatr Clin N Am 18:877-91. 2009
    ..Third, the authors consider attachment theory and the social context of trauma and sleep disruption. This article concludes with a consideration of the therapeutic implications of these findings...
  70. pmc Genetic and metabolic characterization of insomnia
    Hyo Jeong Ban
    Division of Bio Medical Informatics, National Institute of Health, Korea Centers for Disease Control and Prevention, Choongchung Buk do, Korea
    PLoS ONE 6:e18455. 2011
    ....
  71. ncbi Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, and Health Evaluation Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Metabolism 51:887-92. 2002
    ..The daytime shift of IL-6 and TNF secretion, combined with a 24-hour hypersecretion of cortisol, an arousal hormone, may explain the insomniacs' daytime fatigue and difficulty falling asleep...
  72. ncbi Prevalence of DSM-IV diagnostic criteria of insomnia: distinguishing insomnia related to mental disorders from sleep disorders
    M M Ohayon
    Centre de Recherche Philippe Pinel de Montreal, Quebec, Canada
    J Psychiatr Res 31:333-46. 1997
    ..Conversely, diagnoses were obtained by lay interviews, which may have caused a lack of recognition and/or discrimination for light or borderline symptomatology...
  73. ncbi The epidemiology of insomnia: associations with physical and mental health. The HUNT-2 study
    Børge Sivertsen
    Department of Clinical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway
    J Psychosom Res 67:109-16. 2009
    ..The aim of the present study was to examine the association of insomnia symptoms with demographic and physical and mental conditions in a large population-based study...
  74. ncbi A hard day's night: a longitudinal study on the relationships among job demands and job control, sleep quality and fatigue
    Annet H de Lange
    Social and Organizational Psychology, University of Groningen, The Netherlands
    J Sleep Res 18:374-83. 2009
    ....
  75. ncbi Role of melatonin in the regulation of human circadian rhythms and sleep
    C Cajochen
    Center for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstrasse 27, CH 4025 Basel, Switzerland
    J Neuroendocrinol 15:432-7. 2003
    ..We describe the role of melatonin in the regulation of sleep, and the use of exogenous melatonin to treat sleep or circadian rhythm disorders...
  76. ncbi Sleep in the elderly: normal variations and common sleep disorders
    Sonia Ancoli-Israel
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Harv Rev Psychiatry 16:279-86. 2008
    ..Nonpharmacological treatment techniques are discussed; pharmacological treatments are discussed in a companion article...
  77. ncbi Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity
    Peter Meerlo
    Department of Molecular Neurobiology, Center for Behavior and Neurosciences, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Sleep Med Rev 12:197-210. 2008
    ..Indeed, epidemiological studies suggest that sleep complaints and sleep restriction may be important risk factors for a variety of diseases that are often linked to stress, including cardiovascular diseases and mood disorders...
  78. ncbi Daytime consequences and correlates of insomnia in the United States: results of the 1991 National Sleep Foundation Survey. II
    T Roth
    National Sleep Foundation
    Sleep 22:S354-8. 1999
    ..Importantly, most of these variables showed an increasing degree of impairment with greater frequency of sleep disturbance. These findings suggest that insomnia negatively impacts aspects of waking function related to quality of life...
  79. pmc Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety
    Alan G Wade
    CPS Research, Glasgow, UK
    BMC Med 8:51. 2010
    ....
  80. ncbi Trouble sleeping and anxiety/depression in childhood
    E O Johnson
    Department of Psychiatry, Henry Ford Health Sciences Center, Detroit, MI 48202 3450, USA
    Psychiatry Res 94:93-102. 2000
    ..The association of trouble sleeping at age 6 with incidence of depression at age 11 was not statistically significant (suburban children RR=2.22, 95% CI 0.53-9.23; urban children RR=0.92, 95% CI 0.20-4.18)...
  81. ncbi A multicomponent nonpharmacological intervention improves activity rhythms among nursing home residents with disrupted sleep/wake patterns
    Jennifer L Martin
    Multicampus Program in Geriatric Medicine and Gerontology, University of California, Los Angeles, USA
    J Gerontol A Biol Sci Med Sci 62:67-72. 2007
    ..Sleep and circadian rhythms are disrupted among many nursing home (NH) residents. We examined the impact of a multicomponent nonpharmacological intervention on 24-hour rest/activity rhythms among long-stay NH residents...
  82. ncbi Comorbid insomnia: current directions and future challenges
    Thomas Roth
    Henry Ford Hospital Sleep Disorders and Research Center, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Am J Manag Care 15:S6-13. 2009
    ..Recent studies, however, suggest this approach is not the most appropriate. Instead, treating both conditions simultaneously may improve the outcomes for each...
  83. ncbi Daytime sleepiness and sleep habits of Australian workers
    M Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Australia
    Sleep 20:844-9. 1997
    ....
  84. ncbi Insomnia and global sleep dissatisfaction in Finland
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Stanford, CA, USA
    J Sleep Res 11:339-46. 2002
    ..Compared with other European countries studied with the same methodology (France, the UK, Germany, and Italy), the prevalence of DSM-IV insomnia diagnosis was 1.5 to two times higher in Finland...
  85. ncbi The association of insomnia with anxiety disorders and depression: exploration of the direction of risk
    Eric O Johnson
    Behavioral Health Epidemiology Program, Triangle Institute International, PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC, USA
    J Psychiatr Res 40:700-8. 2006
    ..Additionally insomnia may have independent, and potentially etiologically distinct, directional associations with anxiety disorders versus depression...
  86. ncbi Diagnosis and treatment of chronic insomnia: a review
    Ruth M Benca
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Psychiatr Serv 56:332-43. 2005
    ..Insomnia has high prevalence rates and is associated with significant personal and socioeconomic burden, yet it remains largely underrecognized and inadequately treated...
  87. ncbi British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders
    S J Wilson
    Psychopharmacology Unit, University of Bristol, Bristol, UK
    J Psychopharmacol 24:1577-601. 2010
    ..All comments were incorporated as far as possible in the final document, which represents the views of all participants although the authors take final responsibility for the document...
  88. ncbi Place of chronic insomnia in the course of depressive and anxiety disorders
    Maurice M Ohayon
    Stanford Epidemiology Sleep Research Center, Stanford University, 401 Quarry Road Suite 3301, School of Medicine, Stanford, CA 94305, USA
    J Psychiatr Res 37:9-15. 2003
    ..However, little is known about how the chronicity of insomnia affects this relation and how often subjects with chronic insomnia have antecedents of psychiatric disorders...
  89. ncbi The impact of insomnia on cognitive functioning in older adults
    M Cricco
    Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    J Am Geriatr Soc 49:1185-9. 2001
    ..More sensitive measures of cognitive performance may identify more subtle declines and may confirm whether insomnia is associated with cognitive decline in women...
  90. ncbi Societal costs of insomnia
    Damien Leger
    Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Hotel Dieu de Paris, Sleep and Vigilance Center Centre du Sommeil et de la Vigilance, 1 pl du Parvis Notre Dame, 75181 Paris Cedex 04, France
    Sleep Med Rev 14:379-89. 2010
    ....
  91. pmc (Mis)perception of sleep in insomnia: a puzzle and a resolution
    Allison G Harvey
    Department of Psychology, University of California, Berkeley, 3210 Tolman Hall, Berkeley, CA 94720 1650, USA
    Psychol Bull 138:77-101. 2012
    ..The best supported resolutions were misperception of sleep as wake, worry, and brief awakenings. A deficit in time estimation ability was not supported. We conclude by proposing several integrative solutions...
  92. pmc The association between sleep duration and obesity in older adults
    S R Patel
    Division of Pulmonary, Critical Care, and Sleep Medicine and Center for Clinical Investigation, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Obes (Lond) 32:1825-34. 2008
    ..In this study, the cross-sectional associations between sleep duration measured objectively and measures of weight and body composition were assessed in two cohorts of older adults...
  93. pmc Sleep duration and risk of ischemic stroke in postmenopausal women
    Jiu Chiuan Chen
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC 27599 7435, USA
    Stroke 39:3185-92. 2008
    ..Many studies have shown a U-shape association between sleep duration and mortality, but epidemiological evidence linking cardiovascular diseases with habitual sleep patterns is limited and mixed...
  94. ncbi Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant
    P Hoever
    Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland
    Clin Pharmacol Ther 87:593-600. 2010
    ..Population pharmacokinetic/pharmacodynamic modeling suggested that doses of ~500 mg almorexant and 10 mg zolpidem are equivalent with respect to subjectively assessed alertness...
  95. ncbi Cognitive-behavioral therapy for primary insomnia
    Jack D Edinger
    Department of Veterans Affairs and Duke University Medical Centers, Durham, NC, USA
    Clin Psychol Rev 25:539-58. 2005
    ..Finally, remaining questions regarding CBT's application to PI are considered, and suggestions for future research are provided...
  96. ncbi Overview of the therapeutic management of insomnia with zolpidem
    Yue Joe Lee
    Department of Psychiatry, National Taiwan University, Taiwan
    CNS Drugs 18:17-23; discussion 41, 43-5. 2004
    ....
  97. ncbi Diagnosis, prevalence, pathways, consequences & treatment of insomnia
    Wilfred R Pigeon
    Sleep and Neurophysiology Research Laboratory, Department of Psychiatry, University of Rochester Medical Center, New York, USA
    Indian J Med Res 131:321-32. 2010
    ..Both sedative-hypnotic and cognitivebehavioural interventions exist for insomnia and each type of intervention have substantial levels of empirical support for their efficacy...
  98. ncbi Complaints of insomnia among midlife employed people: the contribution of childhood and present socioeconomic circumstances
    Tea Lallukka
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Sleep Med 11:828-36. 2010
    ..This study therefore aimed to examine the associations of both past and present socioeconomic circumstances with complaints of insomnia...
  99. ncbi Use of the wrist actigraph to study insomnia in older adults
    J O Brooks
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305
    Sleep 16:151-5. 1993
    ..Because the actigraph can be used more easily and less expensively than the polysomnogram, the actigraph appears to be a promising measure for assessing the efficacy of treatment interventions in elderly insomniacs...
  100. pmc Persecutory ideation and insomnia: findings from the second British National Survey of Psychiatric Morbidity
    Daniel Freeman
    King s College London, Department of Psychology, PO Box 077, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK
    J Psychiatr Res 44:1021-6. 2010
    ..Longitudinal studies of insomnia and paranoia, and tests of the effects of sleep interventions on levels of paranoia, are now required to examine causality...
  101. ncbi The treatments of chronic insomnia: a review of benzodiazepine receptor agonists and psychological and behavioral therapies
    Dieter Riemann
    Center for Sleep Research and Sleep Medicine, Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Hauptstrasse 5, 79104 Freiburg, Germany
    Sleep Med Rev 13:205-14. 2009
    ..Finally, it is particularly important that studies be conducted to determine if successful insomnia treatment influences the clinical course of the diseases that often occur co-morbidly with sleep continuity disturbance...

Research Grants68

  1. ROLE OF MELATONIN IN SECONDARY INSOMNIA IN THE ELDERLY
    Nalaka Gooneratne; Fiscal Year: 2004
    ....
  2. Novel Therapeutics in PTSD: A Randomized Clinical Trial of Mifepristone
    Gerardo Villarreal; Fiscal Year: 2013
    ..Several measures of neuroendocrine functioning will also be obtained to explore the relationship of plasma cortisol and ACTH levels to clinical response and the time to addition of rescue medications. ..
  3. Cortical GABA in MDD and Primary Insomnia with Magnetic Resonance Spectroscopy
    John W Winkelman; Fiscal Year: 2013
    ..We will also use regression analysis to correlate PSG and sleep diary information, with 1H-MRS-derived GABA data. ..
  4. Prospective Assessment of The Etiology of Insomnia in Middle Aged &Elder Adults
    MICHAEL LLOYD PERLIS; Fiscal Year: 2013
    ..assess which of the theory driven factors best accounts for (alone and in combination) the various clinical course scenarios;and 3) determine if lab based biological measures distinguish between the various clinical course scenarios ..
  5. Sleep in Cardiac patients with Implantable Cardioverter Defibrillators (ICD)
    CHRISTINA MCCRAE; Fiscal Year: 2009
    ..e., chronic pain), but also for those suffering from other behavioral/heath concerns (i.e., weight management, depression). ..
  6. Understanding the sleep apnea/insomnia interaction: a CPAP/sham-CPAP trial
    Nalaka S Gooneratne; Fiscal Year: 2013
    ....
  7. Telemedicine Management of Veterans with Chronic Insomnia and PTSD
    Samuel T Kuna; Fiscal Year: 2013
    ..This would significantly increase access to treatment, particularly for Veterans residing in remote and rural settings, and decrease treatment-related costs. ..
  8. Efficacy and mechanisms of a behavioral therapy for insomnia coexisting with COPD
    Mary C Kapella; Fiscal Year: 2013
    ....
  9. Preventing Depression in Later Life: A Model for Low and Middle Income Countries
    Charles F Reynolds; Fiscal Year: 2013
    ....
  10. Mechanisms that regulate zebrafish Hypocretin neuron development and function
    DAVID AARON PROBER; Fiscal Year: 2013
    ..The proposed studies will improve understanding of the genetic and neuronal mechanisms that regulate sleep and may suggest new strategies to treat sleep disorders. ..
  11. Individually tailored lighting system to improve sleep in older adults
    MARIANA FIGUEIRO; Fiscal Year: 2013
    ....
  12. The effectiveness of non-pharmacological treatment for perinatal insomnia
    Rachel Manber; Fiscal Year: 2013
    ....
  13. Treatment of Comorbid Insomnia in Military Veterans
    Anne Germain; Fiscal Year: 2010
    ..The development of brief behavioral treatments for insomnia that are easily transportable to care settings where veterans seek help can improve mental and physical health outcomes in ex-service members. ..
  14. Sleep and Pain Interventions in Fibromyalgia: Hyperalgesia and Central Sensitizat
    Christina S McCrae; Fiscal Year: 2012
    ..e., cancer patients), but also for those suffering from other behavioral/heath concerns (i.e., weight management, depression). ..
  15. Aging: Insomnia Treatment and Energy Balance
    Sarosh J Motivala; Fiscal Year: 2010
    ....
  16. Efficacy of melatonin treatment in a phase advance model of insomnia
    Jeanne F Duffy; Fiscal Year: 2013
    ..This study will provide important information regarding the mechanism of action of melatonin that will be critical for the use of melatonin as a treatment for circadian rhythm sleep disorders. ..
  17. Rehabilitation of Stress-Induced Insomnia
    Pingfu Feng; Fiscal Year: 2009
    ....
  18. Novel Algorithms and Device for Quantification of Wake-Sleep States
    STEPHANE BIBIAN; Fiscal Year: 2010
    ....
  19. Effects of Insomnia on Pain &Function in Osteoarthritis:The Role of Inflammation
    Michael T Smith; Fiscal Year: 2013
    ..Therefore, the proposed project is likely to generate findings that will have a novel and substantial impact on the prevention, management and treatment of OA. ..
  20. Cognitive Behavioral Treatment of Insomnia in Posttraumatic Stress Disorder
    Thomas C Neylan; Fiscal Year: 2010
    ..Subjects randomized to CBT-I will have repeat assessments and procedures (except polysomnography) at 6 and 12 months post treatment to test for durability of treatment gains. ..
  21. Development and Piloting of CBT for Insomnia in Youth with Comorbid Depression
    Gregory N Clarke; Fiscal Year: 2010
    ..We plan to create and test an insomnia treatment to improve adolescent depression outcomes, as well as improving sleep. ..
  22. Attention Bias as an Etiologic Factor in Primary and Secondary Insomnia
    MICHAEL LLOYD PERLIS; Fiscal Year: 2012
    ..diagnosis). ..
  23. 1/2-Sequenced Therapies for Comorbid and Primary Insomnias
    Jack D Edinger; Fiscal Year: 2013
    ..Our over-arching goal is to obtain new information that contributes to the development of clinical guidelines for PI and CMI management. ..
  24. 2/2-Sequenced Therapies for Comorbid and Primary Insomnias
    Charles M Morin; Fiscal Year: 2013
    ..Our over-arching goal is to obtain new information that contributes to the development of clinical guidelines for PI and CMI management. ..
  25. Evaluation of yoga as a treatment for insomnia in posttraumatic stress disorder
    JESSICA JOY NOGGLE; Fiscal Year: 2013
    ....
  26. Internet-based therapy to improve sleep in rural breast cancer survivors
    MICHAELA MCCARTHY; Fiscal Year: 2013
    ....
  27. CBT +/- Modafinil for Insomnia and Fatigue following Chemotherapy
    Joseph A Roscoe; Fiscal Year: 2012
    ..In addition, pre- and post-intervention polysomnographic assessments will be conducted in 100 of the 226 patients in order to characterize the effects of these interventions on sleep architecture. ..
  28. Amygdalar Modulation of Fear-Conditioned Changes in REM Sleep
    ADRIAN MORRISON; Fiscal Year: 2009
    ..It is very important to investigate the serotonergic modulation of CFC in animals because drugs that influence 5-HT function have widespread acceptance for treating PTSD yet little is known about their actions in related animal models. ..
  29. Treating Sleep Problems in VA Adult Day Health Care
    Jennifer Martin; Fiscal Year: 2009
    ..Findings from this study can inform ongoing re-organization of VA long-term care services, and enhance the quality and outcomes of VA ADHC programs. ..
  30. Longitudinal Study of Predisoposition and Life Events in Triggering Insomnia
    Christopher L Drake; Fiscal Year: 2013
    ..abstract_text> ..
  31. Neuroendocrine Mechanisms in Yoga Treatment of Insomnia
    SAT BIR KHALSA; Fiscal Year: 2007
    ..If achieved, these results will provide a novel demonstration of a reduction of arousal in a behavioral insomnia treatment and a behaviorally enhanced melatonin secretion under controlled laboratory conditions. ..
  32. Genetic Analysis of Sleep Disorders in Zebrafish
    David Prober; Fiscal Year: 2009
    ..Zebrafish will also be used to identify new genes that regulate sleep and may be involved in human sleep disorders. ..
  33. OUTCOME AND PROCESS ANALYSES OF THERAPEUTIC PARADOXES
    Varda Shoham; Fiscal Year: 1992
    ..Additionally, the construct of reactance is further explicated and developments in regards to its non-verbal measurement are detailed. Changes and additions are indicated by bold type...
  34. Melatonin Randomized Trial in Insomnia in the Elderly
    Nalaka Gooneratne; Fiscal Year: 2006
    ..abstract_text> ..
  35. The Psychoneuroimmunology of Insomnia: Response to a Vaccine Challenge
    WILFRED PIGEON; Fiscal Year: 2009
    ....
  36. R21 project: Yoga as a Treatment for Insomnia
    SAT BIR KHALSA; Fiscal Year: 2002
    ..We also anticipate that these improvements will be maintained at long-term follow up evaluation. ..
  37. Hypocretins and Their Role in the Control of Sleep
    RICHARD MAKI; Fiscal Year: 2002
    ..Based on the available data, it is reasonable to hypothesize that hypocretin receptor antagonists will promote non-REM and REM sleep. ..
  38. Outcomes of Sleep Disorders in Older Men-Palo Alto
    Marcia Stefanick; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  39. Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms
    Michael R Irwin; Fiscal Year: 2010
    ..This project will constitute the first, randomized controlled clinical trial of the effects of TCC on sleep outcomes in breast cancer survivors, and will advance psychobiological models of insomnia treatment mechanisms. ..
  40. Outcomes of Sleep Disorders in Older Men
    Elizabeth Barrett Connor; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  41. Outcomes of Sleep Disorders in Older Men-Portland
    Eric Orwoll; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  42. Outcomes of Sleep Disorders in Older Men-Birmingham
    Cora Lewis; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  43. Outcomes of Sleep Disorders in Older Men-Minneapolis
    Kristine Ensrud; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  44. Outcomes of Sleep Disorders in Older Men - Pittsburgh
    Jane Cauley; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. [unreadable] [unreadable]..
  45. Stress Reactivity in Insomnia
    Philip Gehrman; Fiscal Year: 2009
    ..Increasing our understanding of the etiology of insomnia may improve prevention and treatment of the condition and reduce the large public health burden of insomnia. ..
  46. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  47. BEHAVIORAL AND PHARMACOLOGICAL TREATMENT FOR INSOMNIA
    Charles Morin; Fiscal Year: 2005
    ....
  48. ABUSE LIABILITY OF ETHANOL AS A HYNOTIC BY INSOMNIACS
    Timothy Roehrs; Fiscal Year: 2000
    ..In the last two years, the grant focus will be on the extent to which hypnotic ethanol self-administration generalizes to daytime ethanol use. ..
  49. Functional Changes Induced By Sleep Deprivation
    Giulio Tononi; Fiscal Year: 2004
    ..These studies should provide insights into the molecular consequences of prolonged sleep deprivation and chronic insomnia and suggest new therapeutic approaches. ..
  50. MELATONIN ANALOG FOR JET LAG
    CHERYLE WEBB; Fiscal Year: 2005
    ..Clinical adverse events, solicited and by spontaneous report, will be recorded. Prediction: PD6735 at a dose of 25 mg for 4 days will be well tolerated with a frequency of adverse events not different from placebo. ..
  51. COMPUTERIZED SELF-HELP TREATMENT FOR PRIMARY INSOMNIA
    William Riley; Fiscal Year: 2000
    ..abstract_text> ..
  52. CBT for Chronic Insomnia in Breast Cancer Survivors
    Raine Riggs; Fiscal Year: 2004
    ..It is also hypothesized that increased sleep quality will be related to decreased levels of depressive symptoms, fatigue, and pain. ..
  53. Spectrum of Narcolepsy in the Probands Families
    MAURICE OHAYON; Fiscal Year: 2007
    ..A blood sample (3-5 ml) will be asked also to all participants. This will allow us to link some genetic markers of narcolepsy to specific symptoms even in subjects without the full-fledge manifestation of the disease. ..
  54. Safety and Pharmacokinetics of PD6735 in the Elderly
    JAMES MULCHAHEY; Fiscal Year: 2005
    ..Specific Aim 3: Determine the pharmacokinetics of PD6735 in healthy elderly at doses up to 100 mg. Aim 4: Evaluate the pharmacodynamics of PD6735 in healthy elderly at doses up to 100 mg. ..
  55. Neural circuitry in stress-induced insomnia
    Georgina Cano; Fiscal Year: 2005
    ....
  56. COMPUTERIZED SELF-HELP TREATMENT FOR PRIMARY INSOMNIA
    BRADFORD APPLEGATE; Fiscal Year: 2004
    ..The results of this project could produce an empirically validated behavioral treatment for insomnia, which is easily accessed by the millions of people suffering from chronic primary insomnia. ..
  57. Classifying Psychiatric, Medical, and Primary Insomnias
    Jack Edinger; Fiscal Year: 2007
    ..This project will provide a much-needed comparison of these two insomnia nosologies and the subtypes they define. Results also likely will provide important information for future insomnia classification efforts. ..
  58. CBT for Secondary Insomnia in Chronic Pain Patients
    Michael Perlis; Fiscal Year: 2005
    ..It is anticipated that studies of this kind will provide the kind of evidence required to make CBT-I a standard of practice for the management of chronic pain. ..
  59. DOSE/RESPONSE EFFECTS OF BEHAVIORAL INSOMNIA THERAPY
    Jack Edinger; Fiscal Year: 2001
    ..We should also develop a better understanding of the time course over which treatment-related improvements might be expected for insomniacs in general and for specific primary insomniac subtypes. ..
  60. ENHANCING EFFECTIVENESS OF LIGHT THERAPY FOR INSOMNIA
    HENRY SAVAGE; Fiscal Year: 2000
    ....
  61. Sleep EEG Spectral Measures of Insomnia
    Jack Edinger; Fiscal Year: 2004
    ..abstract_text> ..
  62. Behavioral Insomnia Therapy With Fibromyalgia
    Jack Edinger; Fiscal Year: 2009
    ..g., pain, fatigue). Results of this trial should provide insights into the pathophysiology and management of FM. ..
  63. Neurobiology of Insomnia as Measured with FMRI
    Henry Orff; Fiscal Year: 2007
    ..Avenues for future investigation may include studies of insomnia subtypes (e.g., subjective versus objective) and/or new approaches to treatment of insomnia. [unreadable] [unreadable] [unreadable]..
  64. Contributions of sleep/rhythms/fatigue to "chemobrain"
    Sonia Ancoli Israel; Fiscal Year: 2009
    ..The reported phenomena of chemobrain will be examined to see if it is related to the complaint of fatigue or sleep disruptions, both of which are known to contribute to decreases in cognitive functioning. ..
  65. FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCER
    Sonia Ancoli Israel; Fiscal Year: 2004
    ..Results will provide a scientific basis for future intervention studies, particularly studies with light therapy which can re-synchronize rhythms. ..
  66. RATIONAL PHARMACOTHERAPY OF PRIMARY INSOMNIA
    Daniel Buysse; Fiscal Year: 2004
    ..The Principal Investigator will mentor trainees in analyses of existing data, design and implementation of the clinical trial, described above, and new studies designed by the trainees themselves. ..
  67. OPTIMIZATION OF ELECTROCONVULSIVE THERAPY
    WILLIAM MCCALL; Fiscal Year: 2005
    ....
  68. Is Insomnia a Modifiable Risk Factor for MDD?
    Michael Perlis; Fiscal Year: 2006
    ..abstract_text> ..