narcolepsy

Summary

Summary: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)

Top Publications

  1. ncbi Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, Colindale, London NW9 5EQ, UK
    BMJ 346:f794. 2013
  2. pmc AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland
    Hanna Nohynek
    Department of Vaccines and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 7:e33536. 2012
  3. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999
  4. ncbi The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    L Lin
    Center for Narcolepsy, Department of Psychiatry, Stanford University School of Medicine, California 94305 5485, USA
    Cell 98:365-76. 1999
  5. ncbi A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    C Peyron
    Center for Narcolepsy, Stanford University Medical School 1201 Welch Road, Stanford, California 94305 5485, USA
    Nat Med 6:991-7. 2000
  6. pmc Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland
    Markku Partinen
    Helsinki Sleep Clinic, Vitalmed Research Centre, Helsinki, Finland
    PLoS ONE 7:e33723. 2012
  7. ncbi The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns
    Leonoor Wijnans
    Erasmus University Medical Center, Rotterdam, The Netherlands
    Vaccine 31:1246-54. 2013
  8. pmc Narcolepsy is strongly associated with the T-cell receptor alpha locus
    Joachim Hallmayer
    Center for Sleep Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Genet 41:708-11. 2009
  9. ncbi Differential expression of orexin receptors 1 and 2 in the rat brain
    J N Marcus
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 435:6-25. 2001
  10. ncbi Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss?
    Adriano Fontana
    Institute of Experimental Immunology, University Hospital Zurich, Haeldeliweg 4, CH 8044 Zurich, Switzerland
    Brain 133:1300-11. 2010

Detail Information

Publications311 found, 100 shown here

  1. ncbi Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency, Colindale, London NW9 5EQ, UK
    BMJ 346:f794. 2013
    To evaluate the risk of narcolepsy in children and adolescents in England targeted for vaccination with ASO3 adjuvanted pandemic A/H1N1 2009 vaccine (Pandemrix) from October 2009.
  2. pmc AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland
    Hanna Nohynek
    Department of Vaccines and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 7:e33536. 2012
    b>Narcolepsy is a chronic sleep disorder with strong genetic predisposition causing excessive daytime sleepiness and cataplexy...
  3. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999
    ..and electroencephalographic criteria, orexin knockout mice exhibit a phenotype strikingly similar to human narcolepsy patients, as well as canarc-1 mutant dogs, the only known monogenic model of narcolepsy...
  4. ncbi The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    L Lin
    Center for Narcolepsy, Department of Psychiatry, Stanford University School of Medicine, California 94305 5485, USA
    Cell 98:365-76. 1999
    b>Narcolepsy is a disabling sleep disorder affecting humans and animals. It is characterized by daytime sleepiness, cataplexy, and striking transitions from wakefulness into rapid eye movement (REM) sleep...
  5. ncbi A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    C Peyron
    Center for Narcolepsy, Stanford University Medical School 1201 Welch Road, Stanford, California 94305 5485, USA
    Nat Med 6:991-7. 2000
    We explored the role of hypocretins in human narcolepsy through histopathology of six narcolepsy brains and mutation screening of Hcrt, Hcrtr1 and Hcrtr2 in 74 patients of various human leukocyte antigen and family history status...
  6. pmc Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland
    Markku Partinen
    Helsinki Sleep Clinic, Vitalmed Research Centre, Helsinki, Finland
    PLoS ONE 7:e33723. 2012
    b>Narcolepsy is a rare neurological sleep disorder especially in children who are younger than 10 years...
  7. ncbi The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns
    Leonoor Wijnans
    Erasmus University Medical Center, Rotterdam, The Netherlands
    Vaccine 31:1246-54. 2013
    ..of a possible association between exposure to AS03 adjuvanted pandemic A(H1N1)pdm09 vaccine and occurrence of narcolepsy in children and adolescents emerged in Sweden and Finland...
  8. pmc Narcolepsy is strongly associated with the T-cell receptor alpha locus
    Joachim Hallmayer
    Center for Sleep Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Genet 41:708-11. 2009
    b>Narcolepsy with cataplexy, characterized by sleepiness and rapid onset into REM sleep, affects 1 in 2,000 individuals. Narcolepsy was first shown to be tightly associated with HLA-DR2 (ref. 3) and later sublocalized to DQB1*0602 (ref. 4)...
  9. ncbi Differential expression of orexin receptors 1 and 2 in the rat brain
    J N Marcus
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 435:6-25. 2001
    ..The differential distribution of orexin receptors is consistent with the proposed multifaceted roles of orexin in regulating homeostasis and may explain the unique role of the OX(2)R receptor in regulating sleep state stability...
  10. ncbi Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss?
    Adriano Fontana
    Institute of Experimental Immunology, University Hospital Zurich, Haeldeliweg 4, CH 8044 Zurich, Switzerland
    Brain 133:1300-11. 2010
    Human narcolepsy with cataplexy is a neurological disorder, which develops due to a deficiency in hypocretin producing neurons in the hypothalamus. There is a strong association with human leucocyte antigens HLA-DR2 and HLA-DQB1*0602...
  11. ncbi Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination
    Attila Szakács
    Department of Children, County Hospital, Halmstad, Sweden
    Neurology 80:1315-21. 2013
    To assess the incidence of narcolepsy between January 2000 and December 2010 in children in western Sweden and its relationship to the Pandemrix vaccination, and to compare the clinical and laboratory features of these children.
  12. ncbi Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
    Hyun Hor
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Nat Genet 42:786-9. 2010
    b>Narcolepsy is a rare sleep disorder with the strongest human leukocyte antigen (HLA) association ever reported...
  13. ncbi Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China
    Fang Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Ann Neurol 70:410-7. 2011
    b>Narcolepsy is caused by the loss of hypocretin/orexin neurons in the hypothalamus, which is likely the result of an autoimmune process...
  14. ncbi Dopaminergic role in stimulant-induced wakefulness
    J P Wisor
    Sleep Disorders Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 21:1787-94. 2001
    ..Thus, dopamine transporters play an important role in sleep regulation and are necessary for the specific wake-promoting action of amphetamines and modafinil...
  15. pmc Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
    Juliane Winkelmann
    Institute of Human Genetics, Technische Universitat Munchen, Munich 81675, Germany
    Hum Mol Genet 21:2205-10. 2012
    Autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCA-DN) is characterized by late onset (30-40 years old) cerebellar ataxia, sensory neuronal deafness, narcolepsy-cataplexy and dementia...
  16. ncbi Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A
    M S Heier
    Norwegian Resource Center for AD HD, Oslo University Hospital, Norway
    Sleep Med 14:867-71. 2013
    ..The vaccination coverage in this age cohort was approximately 50%...
  17. pmc Executive control of attention in narcolepsy
    Sophie Bayard
    National Reference Network for Narcolepsy, Department of Neurology, Hopital Gui de Chauliac, CHU Montpellier, Montpellier, France
    PLoS ONE 7:e33525. 2012
    b>Narcolepsy with cataplexy (NC) is a disabling sleep disorder characterized by early loss of hypocretin neurons that project to areas involved in the attention network...
  18. ncbi HLA-DQ association and allele competition in Chinese narcolepsy
    F Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Tissue Antigens 80:328-35. 2012
    In Japanese, Koreans and Caucasians, narcolepsy/hypocretin deficiency is tightly associated with the DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype...
  19. ncbi Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes
    Jon T Willie
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 38:715-30. 2003
    b>Narcolepsy-cataplexy, a neurological disorder associated with the absence of hypothalamic orexin (hypocretin) neuropeptides, consists of two underlying problems: inability to maintain wakefulness and intrusion of rapid eye movement (REM) ..
  20. pmc Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset
    Adi Aran
    Center for Sleep Sciences and Department of Psychiatry, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Sleep 32:979-83. 2009
    b>Narcolepsy-cataplexy has long been thought to have an autoimmune origin...
  21. ncbi A 5-year prospective cohort study on health-related quality of life in patients with narcolepsy
    Luca Vignatelli
    Ambulatorio di Neurologia, Polo Sanitario Barberini di Crevalcore, AUSL di Bologna, Bologna, Italy
    Sleep Med 12:19-23. 2011
    To evaluate the 5-year variation of health-related quality of life (HRQoL) and mood symptoms in a cohort of patients with narcolepsy.
  22. ncbi Pandemic influenza A H1N1 vaccines and narcolepsy: vaccine safety surveillance in action
    Charlotte I S Barker
    Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, UK Oxford University Clinical Academic Graduate School, Medical Sciences Division, University of Oxford, Oxford, UK Electronic address
    Lancet Infect Dis 14:227-38. 2014
    ..Clinicians in Finland and Sweden later identified an apparent increase in the incidence of narcolepsy associated with a specific adjuvanted pandemic influenza vaccine...
  23. ncbi The role of hypocretins (orexins) in sleep regulation and narcolepsy
    Shahrad Taheri
    Stanford University Center for Narcolepsy, 701 Welch Road B, Basement, Palo Alto, California 94304 5742, USA
    Annu Rev Neurosci 25:283-313. 2002
    ..Deficiency in hypocretin neurotransmission results in the sleep disorder narcolepsy in mice, dogs, and humans...
  24. pmc ImmunoChip study implicates antigen presentation to T cells in narcolepsy
    Juliette Faraco
    Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California, USA
    PLoS Genet 9:e1003270. 2013
    ..genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency...
  25. pmc Decision making in narcolepsy with cataplexy
    Sophie Bayard
    Service de Neurologie, Unite des troubles du sommeil, Hôpital Gui de Chauliac Montpellier, France
    Sleep 34:99-104. 2011
    To investigate decision-making and addictive behaviors in narcolepsy-cataplexy (NC). NC is caused by the loss of hypothalamic neurons that produce hypocretins...
  26. pmc Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy
    Hiromi Toyoda
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Sleep 33:875-8. 2010
    b>Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and cataplexy. The association with human leukocyte antigen (HLA)-DQB1*0602 and T-cell receptor alpha locus suggests that autoimmunity plays a role in narcolepsy...
  27. ncbi Factors associated with a delay in the diagnosis of narcolepsy
    Emma Morrish
    Respiratory Support and Sleep Centre, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UK
    Sleep Med 5:37-41. 2004
    There can be a long interval from the onset of symptoms before a diagnosis of narcolepsy is made. There are no multivariate analyses reported in the literature of factors that may contribute to this delay...
  28. ncbi Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    J Hara
    Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neuron 30:345-54. 2001
    ..Recent reports suggest that loss of orexin-containing neurons occurs in human patients with narcolepsy. We generated transgenic mice in which orexin-containing neurons are ablated by orexinergic-specific expression ..
  29. pmc Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden
    Carola Bardage
    Medical Products Agency, PO Box 26, SE 751 03 Uppsala, Sweden
    BMJ 343:d5956. 2011
    ..To examine the risk of neurological and autoimmune disorders of special interest in people vaccinated against pandemic influenza A (H1N1) with Pandemrix (GlaxoSmithKline, Middlesex, UK) compared with unvaccinated people over 8-10 months...
  30. pmc Concomitant loss of dynorphin, NARP, and orexin in narcolepsy
    A Crocker
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 65:1184-8. 2005
    b>Narcolepsy with cataplexy is associated with a loss of orexin/hypocretin. It is speculated that an autoimmune process kills the orexin-producing neurons, but these cells may survive yet fail to produce orexin.
  31. ncbi Narcolepsy with cataplexy
    Yves Dauvilliers
    Neurologie, CHU Montpellier Hôpital Gui de Chauliac and INSERM U888, Montpellier France
    Lancet 369:499-511. 2007
    b>Narcolepsy with cataplexy is a disabling sleep disorder affecting 0.02% of adults worldwide...
  32. pmc Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients
    Vesna Cvetkovic-Lopes
    Département de Neurosciences Fondamentales, Centre Medical Universitaire, Geneve, Switzerland
    J Clin Invest 120:713-9. 2010
    b>Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and attacks of muscle atonia triggered by strong emotions (cataplexy)...
  33. pmc Common variants in P2RY11 are associated with narcolepsy
    Birgitte R Kornum
    Center for Sleep Sciences and Department of Psychiatry, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Genet 43:66-71. 2011
    Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune disease...
  34. ncbi The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study
    Michael H Silber
    Sleep Disorders Center, Department of Neurology, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905, USA
    Sleep 25:197-202. 2002
    To determine the age- and sex-specific incidence rates and prevalence of narcolepsy in a United States community.
  35. ncbi Health-related quality of life in Italian patients with narcolepsy: the SF-36 health survey
    Luca Vignatelli
    Dipartimento di Scienze Neurologiche, Universita degli Studi di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy
    Sleep Med 5:467-75. 2004
    ..of the 36-item short form (SF-36), a tool measuring health-related quality of life (HRQoL) in patients with narcolepsy or other sleep disorders, presenting excessive daytime sleepiness (EDS) as the main symptom...
  36. pmc Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children
    Adi Aran
    Neuro Pediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel
    Sleep 33:1457-64. 2010
    to report on symptoms and therapies used in childhood narcolepsy-cataplexy.
  37. ncbi The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder
    Pierre Hervé Luppi
    UMR5167 CNRS, Institut Fédératif des Neurosciences de Lyon IFR 19, Univ Lyon 1, Universite de Lyon, Lyon, France
    Sleep Med Rev 15:153-63. 2011
    ..Conversely, cataplexy, one of the key symptoms of narcolepsy, is a striking sudden episode of muscle weakness triggered by emotions during wakefulness, and comparable to REM ..
  38. ncbi Hypocretin levels in sporadic and familial cases of canine narcolepsy
    B Ripley
    Center for Narcolepsy, Stanford Sleep Center, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Neurobiol Dis 8:525-34. 2001
    Familial and sporadic forms of narcolepsy exist in both humans and canines. Mutations in the hypocretin receptor 2 gene (Hcrtr 2) cause canine familial narcolepsy...
  39. ncbi A putative flip-flop switch for control of REM sleep
    Jun Lu
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 441:589-94. 2006
    ..The mutually inhibitory interactions of the REM-on and REM-off areas may form a flip-flop switch that sharpens state transitions and makes them vulnerable to sudden, unwanted transitions-for example, in narcolepsy.
  40. pmc Complex movement disorders at disease onset in childhood narcolepsy with cataplexy
    Giuseppe Plazzi
    Department of Neurological Sciences, University of Bologna, 40123 Bologna, Italy
    Brain 134:3480-92. 2011
    b>Narcolepsy with cataplexy is characterized by daytime sleepiness, cataplexy (sudden loss of bilateral muscle tone triggered by emotions), sleep paralysis, hypnagogic hallucinations and disturbed nocturnal sleep...
  41. ncbi Reduced amygdala activity during aversive conditioning in human narcolepsy
    Aurélie Ponz
    Department of Neuroscience, University of Geneva, Geneva, Switzerland
    Ann Neurol 67:394-8. 2010
    b>Narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. Here we assessed the time course of amygdala activation during aversive conditioning in unmedicated patients with narcolepsy...
  42. ncbi Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France
    Yves Dauvilliers
    Sleep Disorder Centre, Neurology Department, Gui de Chauliac Hospital, CHU Montpellier, INSERM, U1061, Montpellier, France
    Brain 136:2486-96. 2013
    An increased incidence of narcolepsy in children was detected in Scandinavian countries where pandemic H1N1 influenza ASO3-adjuvanted vaccine was used...
  43. pmc No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood narcolepsy after Pandemrix vaccination campaign in Finland
    Krister Melen
    Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland
    PLoS ONE 8:e68402. 2013
    b>Narcolepsy cataplexy syndrome, characterised by excessive daytime sleepiness and cataplexy, is strongly associated with a genetic marker, human leukocyte antigen (HLA) DQB1*06:02...
  44. ncbi Cataplexy-related neurons in the amygdala of the narcoleptic dog
    S Gulyani
    Department of Psychiatry and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 91020, USA
    Neuroscience 112:355-65. 2002
    ..Cataplexy, a symptom of narcolepsy, is a loss of muscle tone usually triggered by sudden, strong emotions...
  45. pmc Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial
    Taku Miyagawa
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e53707. 2013
    b>Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and rapid eye movement (REM) sleep abnormalities...
  46. ncbi Effect of age on MSLT results in patients with narcolepsy-cataplexy
    Y Dauvilliers
    Centre d Etude du Sommeil, Hopital Gui de Chauliac, and INSERM E 0361, Hôpital La Colombière, Montpellier, France
    Neurology 62:46-50. 2004
    ..To measure the effect of age on Multiple Sleep Latency Test (MSLT)characteristics, sleep latency, and number of sleep-onset REM periods (SOREMP) in two large populations of narcoleptic patients with similar genetic backgrounds...
  47. ncbi High pain frequency in narcolepsy with cataplexy
    Yves Dauvilliers
    Department of Neurology, Hopital Gui de Chauliac, CHU Montpellier, National Reference Network for Orphan Diseases Narcolepsy, Montpellier, France
    Sleep Med 12:572-7. 2011
    b>Narcolepsy with cataplexy (NC) is caused by the loss of hypocretin neurons. Recent studies highlighted the roles for hypocretins in the modulation of nociceptive transmission...
  48. ncbi Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain
    Birgitte Rahbek Kornum
    Stanford Center for Sleep Sciences and Medicine, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Curr Opin Neurobiol 21:897-903. 2011
    The loss of hypothalamic hypocretin/orexin (hcrt) producing neurons causes narcolepsy with cataplexy. An autoimmune basis for the disease has long been suspected and recent results have greatly strengthened this hypothesis...
  49. ncbi Amygdala dysfunction in narcolepsy-cataplexy
    Ramin Khatami
    Department of Neurology, University Hospital, Zurich, Switzerland
    J Sleep Res 16:226-9. 2007
    ..Patients with narcolepsy-cataplexy (NC) were found to have normal ASR, but they failed to exhibit startle potentiation during unpleasant ..
  50. ncbi Executive functions, information sampling, and decision making in narcolepsy with cataplexy
    Margarete Delazer
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neuropsychology 25:477-87. 2011
    b>Narcolepsy with cataplexy (NC) affects neurotransmitter systems regulating emotions and cognitive functions. This study aimed to assess executive functions, information sampling, reward processing, and decision making in NC.
  51. pmc Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
    Michihiro Mieda
    Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9050, USA
    Proc Natl Acad Sci U S A 101:4649-54. 2004
    b>Narcolepsy-cataplexy is a neurological disorder associated with the inability to maintain wakefulness and abnormal intrusions of rapid eye movement sleep-related phenomena into wakefulness such as cataplexy...
  52. ncbi Emotional information processing in patients with narcolepsy: a psychophysiologic investigation
    Valter Tucci
    Department of Psychology, University of Padua, Padua, Italy
    Sleep 26:558-64. 2003
    ..Accordingly, we compared the psychophysiologic effects on patients with narcolepsy and healthy subjects of processing visual stimuli that have established emotional valences.
  53. ncbi DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans
    Seung Chul Hong
    Department of Neuropsychiatry, St Vincent s Hospital, The Catholic University of Korea, Suwon, Korea
    Hum Immunol 68:59-68. 2007
    The association of narcolepsy with HLA-DQB1*0602 is established in Japanese, African-Americans, European, and North American Caucasians...
  54. ncbi The genetics of sleep disorders in humans: narcolepsy, restless legs syndrome, and obstructive sleep apnea syndrome
    Emrah Caylak
    Department of Biochemistry and Clinical Biochemistry, Firat University, School of Medicine, Elazig, Turkey
    Am J Med Genet A 149:2612-26. 2009
    ..There is strong evidence emerging for the presence of genes influencing sleep disorders, such as narcolepsy (NRCLP), restless legs syndrome (RLS), and obstructive sleep apnea syndrome (OSAS)...
  55. ncbi Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy
    P C Baier
    Department of Psychiatry and Psychotherapy, Christian Albrecht University, Niemannsweg 147, D 24105 Kiel, Germany
    Sleep Med 12:941-6. 2011
    ..On the one hand, the sleep-wake disorder narcolepsy can be caused by an hcrt-1 deficiency...
  56. ncbi Development of a Japanese version of the Epworth Sleepiness Scale (JESS) based on item response theory
    Misa Takegami
    Department of Epidemiology and Healthcare Research, Graduate School of Medicine and Public Health, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Sleep Med 10:556-65. 2009
    ..Various Japanese versions of the Epworth Sleepiness Scale (ESS) have been used, but none was developed via standard procedures. Here we report on the construction and testing of the developer-authorized Japanese version of the ESS (JESS)...
  57. ncbi Olfactory dysfunction in patients with narcolepsy with cataplexy is restored by intranasal Orexin A (Hypocretin-1)
    Paul Christian Baier
    Department of Psychiatry and Psychotherapy, Christian Albrechts University Kiel, Kiel, Germany
    Brain 131:2734-41. 2008
    Until recently, olfactory dysfunction was an unknown feature of narcolepsy. Orexin A, also called hypocretin-1, is abnormally decreased or undetectable in the cerebrospinal fluid of narcoleptic patients with cataplexies...
  58. ncbi Cognitive evoked potentials in narcolepsy: a review of the literature
    Alberto Raggi
    Department of Neurology I C, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Via Conte Ruggero 73, 94018 Troina, Italy
    Neurosci Biobehav Rev 35:1144-53. 2011
    Subtle cognitive deficits have been described in narcolepsy. They have been hypothesised to be related to changes in the hypocretin system...
  59. ncbi Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications
    Takashi Kanbayashi
    Department of Neuropsychiatry, Akita University School of Medicine, Akita City, Japan
    Arch Neurol 66:1563-6. 2009
    To characterize factors that contribute to symptomatic narcolepsy and excessive daytime sleepiness in neuromyelitis optica and multiple sclerosis.
  60. ncbi Attention deficits in patients with narcolepsy
    Martina Rieger
    Max Planck Institute for Psychological Research, Munich
    Sleep 26:36-43. 2003
    Although attention problems are presumably responsible for a wide variety of difficulties patients with narcolepsy experience in everyday life, empirical investigation of this issue is scarce...
  61. pmc Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features
    Ko Tsutsui
    Akita University, Department of Neuropsychiatry, Akita, Japan
    BMC Psychiatry 12:37. 2012
    ..These symptoms often occur in young females with ovarian teratomas and are frequently associated with serum and CSF autoantibodies to the NMDA receptor (NMDAR)...
  62. ncbi Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives
    S Overeem
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, The Netherlands
    J Clin Neurophysiol 18:78-105. 2001
    b>Narcolepsy is characterized by excessive daytime sleepiness and abnormal manifestations of rapid eye movement sleep such as cataplexy...
  63. pmc TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy
    Fang Han
    Department of Pulmonary Medicine, Peking University People s Hospital, Beijing, China
    Sleep Med 13:269-72. 2012
    Polymorphisms in the TCRA and P2RY11, two immune related genes, are associated with narcolepsy in Caucasians and Asians...
  64. pmc Evidence for metabolic hypothalamo-amygdala dysfunction in narcolepsy
    Rositsa Poryazova
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Sleep 32:607-13. 2009
    ..As neuronal loss and gliosis have been described in narcolepsy, metabolites of primary interest are N-acetylaspartate (NAA), a marker of neuronal integrity and myo-Inositol (..
  65. ncbi Anxiety and mood disorders in narcolepsy: a case-control study
    H A Droogleever Fortuyn
    Department of Psychiatry, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Gen Hosp Psychiatry 32:49-56. 2010
    b>Narcolepsy is a primary sleeping disorder with excessive daytime sleepiness and cataplexy as core symptoms. There is increasing interest in the psychiatric phenotype of narcolepsy...
  66. ncbi Narcolepsy: pathophysiology and neuropsychological changes
    Angela Naumann
    Department of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr University of Bochum, Germany
    Behav Neurol 14:89-98. 2003
    b>Narcolepsy is now recognized as a distinctive disorder with specific pathophysiology and neurochemical abnormalities. Findings on the role of the neuropeptide hypocretin are opening new avenues of research and new strategies for therapy...
  67. pmc Abnormally low serum acylcarnitine levels in narcolepsy patients
    Taku Miyagawa
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Sleep 34:349-53A. 2011
    b>Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and REM sleep abnormalities...
  68. pmc Gray matter concentration abnormality in brains of narcolepsy patients
    Eun Yeon Joo
    Department of Neurology, Sleep Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Korean J Radiol 10:552-8. 2009
    ..To investigate gray matter concentration changes in the brains of narcoleptic patients...
  69. pmc Sodium oxybate-induced sleep driving and sleep-related eating disorder
    Douglas McKay Wallace
    Department of Neurology, Sleep Medicine Division, University of Miami Miller School of Medicine, Miami, FL, USA
    J Clin Sleep Med 7:310-1. 2011
    ..We describe a patient with narcolepsy-cataplexy who experienced one episode of sleep-driving and at least two sleep-related eating episodes with ..
  70. ncbi An approach based on a genome-wide association study reveals candidate loci for narcolepsy
    Mihoko Shimada
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Hum Genet 128:433-41. 2010
    b>Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and a pathological manifestation of rapid eye movement during sleep. Narcoleptic pathogenesis is triggered by both genetic and environmental factors...
  71. pmc High prevalence of eating disorders in narcolepsy with cataplexy: a case-control study
    Hal A Droogleever Fortuyn
    Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Sleep 31:335-41. 2008
    To study the prevalence of and symptoms of eating disorders in patients with narcolepsy.
  72. ncbi Narcolepsy and psychiatry: an evolving association of increasing interest
    H A Droogleever Fortuyn
    Department of Psychiatry, Donders Institute for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Sleep Med 12:714-9. 2011
    Gélineau originally described narcolepsy as a disease with an organic cause...
  73. ncbi Evidence of a perceptual-encoding deficit in narcolepsy?
    G K Henry
    University of California Los Angeles, Department of Neuropsychology 90024
    Sleep 16:123-7. 1993
    ..We propose that a perceptual-encoding deficit may underlie the problems in memory and complex reaction time associated with narcolepsy.
  74. ncbi Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects
    Brian E Leonard
    Department of Pharmacology, National University of Ireland, Galway, Ireland
    Hum Psychopharmacol 19:151-80. 2004
  75. ncbi Focusing on vigilance instead of sleepiness in the assessment of narcolepsy: high sensitivity of the Sustained Attention to Response Task (SART)
    Rolf Fronczek
    Leiden University Medical Centre, Department of Neurology and Clinical Neurophysiology, The Netherlands
    Sleep 29:187-91. 2006
    The severity of narcolepsy is commonly measured with the Multiple Sleep Latency Test (MSLT), focusing on the tendency to fall asleep. A neglected but perhaps equally important complaint is impaired performance in the waking state...
  76. ncbi Health-related quality of life in narcolepsy
    S Ervik
    Norwegian Resource Centre for ADHD, Tourette Syndrome and Narcolepsy, Ulleval University Hospital, Oslo, Norway
    Acta Neurol Scand 114:198-204. 2006
    To describe health-related quality of life in Norwegian patients with narcolepsy compared with data from the general population.
  77. ncbi Diet therapy for narcolepsy
    A M Husain
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Neurology 62:2300-2. 2004
    The effects of a low-carbohydrate, ketogenic diet (LCKD) on sleepiness and other narcolepsy symptoms were studied...
  78. ncbi A case-control study of the environmental risk factors for narcolepsy
    Dante Picchioni
    Department of Psychology, University of Southern Mississippi, Hattiesburg, Mississippi, USA
    Neuroepidemiology 29:185-92. 2007
    Despite the acknowledged importance of environmental risk factors in the etiology of narcolepsy, there is little research on this topic...
  79. ncbi Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB1*1501-DQB1*0602--positive subjects
    Eun Youn Roh
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Hum Immunol 67:749-55. 2006
    ..purpose of this study was to investigate the association of human leukocyte antigen (HLA) class II alleles with narcolepsy-cataplexy susceptibility in Koreans...
  80. pmc Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy
    Minae Kawashima
    Center for Narcolepsy, Stanford University School of Medicine, 701 B Welch Road, Palo Alto, CA 94304, USA
    Sleep 33:869-74. 2010
    Recent studies have found increased autoantibodies against Tribbles homolog 2 (anti-TRIB2) and anti-streptolysin O (ASO) in narcolepsy. In this study, we replicated this finding with a primary focus on recent onset cases.
  81. ncbi Daytime variation in performance and tiredness/sleepiness ratings in patients with insomnia, narcolepsy, sleep apnea and normal controls
    C Schneider
    Clinic of Neurology, HELIOS Klinikum Erfurt, Erfurt, Germany
    J Sleep Res 13:373-83. 2004
    ..course of cognitive functions and subjective alertness in a parallel group design with four groups of patients [narcolepsy, untreated or treated obstructive sleep apnea (OSA), or psychophysiological insomnia] and a control group of ..
  82. ncbi Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy
    Giuseppe Plazzi
    Sleep Disorders Center, Dept of Neurological Sciences, University of Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy
    J Neurol 255:1549-54. 2008
    We report on the outcome of intravenous high-dose immunoglobulin (IVIg) treatment in four children with narcolepsy and cataplexy, in whom the early diagnosis and the extreme disease severity were indications for this potentially ..
  83. ncbi Narcolepsy in childhood
    Sona Nevsimalova
    Department of Neurology, 1st Medical Faculty, Charles University, Katerinska 30, 128 00 Prague 2, Czech Republic
    Sleep Med Rev 13:169-80. 2009
    b>Narcolepsy is a chronic disease commonly diagnosed in middle adulthood. However, the first symptoms often appear in childhood and/or adolescence...
  84. ncbi Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency
    Stine Knudsen
    Danish Center for Sleep Medicine, University of Copenhagen, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    Brain 133:568-79. 2010
    ..movement sleep behaviour disorder is commonly associated with neurodegenerative disorders, but also reported in narcolepsy with cataplexy...
  85. ncbi A pilot study on the effects of sodium oxybate on sleep architecture and daytime alertness in narcolepsy
    Mortimer Mamelak
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Sleep 27:1327-34. 2004
    To measure the effect of nocturnal sodium oxybate administration on sleep architecture in patients with narcolepsy.
  86. ncbi Age at onset of narcolepsy in two large populations of patients in France and Quebec
    Y Dauvilliers
    Service de Neurologie B, Unite des troubles du sommeil, Hopital Gui de Chauliac, Montpellier, France
    Neurology 57:2029-33. 2001
    b>Narcolepsy usually starts around adolescence; however, there is great variability in the clinical presentation of narcolepsy.
  87. ncbi Abnormal activity in reward brain circuits in human narcolepsy with cataplexy
    Aurélie Ponz
    Department of Neuroscience, University of Geneva, Geneva, Switzerland
    Ann Neurol 67:190-200. 2010
    ..In humans, the loss of hypocretin-containing neurons results in a major sleep-wake disorder called narcolepsy-cataplexy, which is associated with emotional disturbances...
  88. ncbi Health-related quality of life in patients with narcolepsy
    Richard Dodel
    Department of Neurology, Philipps University, Marburg, Germany
    Sleep Med 8:733-41. 2007
    To evaluate the health-related quality of life (HRQoL) in patients suffering from narcolepsy.
  89. ncbi Behavioral state instability in orexin knock-out mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 24:6291-300. 2004
    b>Narcolepsy is caused by a lack of orexin (hypocretin), but the physiologic process that underlies the sleepiness of narcolepsy is unknown...
  90. ncbi Hypothalamic gray matter changes in narcoleptic patients
    B Draganski
    Nat Med 8:1186-8. 2002
  91. ncbi The epidemiology of narcolepsy
    W T Longstreth
    Neuroepidemiology Research Group, University of Washington, Seattle, WA, USA
    Sleep 30:13-26. 2007
    Much has been learned about the pathophysiology of narcolepsy over the last several decades...
  92. ncbi A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness
    Seung Chul Hong
    Department of Neuropsychiatry, St Vincent s Hospital, Catholic University of Korea, Suwon, Korea
    Sleep 29:1429-38. 2006
    ....
  93. pmc Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy
    Christian Siebold
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 101:1999-2004. 2004
    The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying these contrasting genetic properties...
  94. ncbi Cognitive deficits in narcolepsy
    A Naumann
    Department of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr University of Bochum, Bochum, Germany
    J Sleep Res 15:329-38. 2006
    The aim of the investigations was to explore the nature and the severity of cognitive deficits in narcolepsy patients...
  95. ncbi CSF hypocretin/orexin levels in narcolepsy and other neurological conditions
    B Ripley
    Stanford University Center for Narcolepsy, Palo Alto, CA 94304, USA
    Neurology 57:2253-8. 2001
    OBJECTIVE: To examine the specificity of low CSF hypocretin-1 levels in narcolepsy and explore the potential role of hypocretins in other neurologic disorders...
  96. ncbi The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy
    C Fehr
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55101, Mainz, Germany
    Psychiatry Res 97:1-10. 2000
    ..depression, 32 patients with panic disorder, 50 patients with generalized anxiety disorder, 58 patients with narcolepsy and 74 healthy volunteers for the HTR1B 861G>C polymorphism...
  97. pmc A consensus definition of cataplexy in mouse models of narcolepsy
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Sleep 32:111-6. 2009
    People with narcolepsy often have episodes of cataplexy, brief periods of muscle weakness triggered by strong emotions...
  98. pmc Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups
    E Mignot
    Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304, USA
    Am J Hum Genet 68:686-99. 2001
    Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1*0602...
  99. ncbi Explorations of clinical trials and pharmacovigilance databases of MF59®-adjuvanted influenza vaccines for associated cases of narcolepsy
    Theodore F Tsai
    Novartis Vaccines and Diagnostics Inc, 350 Massachusetts Avenue, Cambridge, MA 02139, USA
    Scand J Infect Dis 43:702-6. 2011
    A potential association between the new onset of narcolepsy accompanied by cataplexy - a putative autoimmune disorder, and vaccination with an AS03-adjuvanted A(H1N1) pandemic influenza vaccine is under investigation...
  100. pmc IGFBP3 colocalizes with and regulates hypocretin (orexin)
    Makoto Honda
    Sleep Disorder Research Project, Tokyo Institute of Psychiatry, Setagaya, Tokyo, Japan
    PLoS ONE 4:e4254. 2009
    The sleep disorder narcolepsy is caused by a vast reduction in neurons producing the hypocretin (orexin) neuropeptides...
  101. pmc Narcolepsy: immunological aspects
    Sebastiaan Overeem
    Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Sleep Med Rev 12:95-107. 2008
    b>Narcolepsy with cataplexy is a debilitating sleep disorder with an estimated prevalence of about 0.05%. Narcolepsy is caused by a selective loss of hypocretin (orexin) producing neurons in the perifornical hypothalamus...

Research Grants64

  1. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..rational development of treatments for sleep disorders affecting the veteran population, such as sleep apnea, narcolepsy, insomnia, and sleep disturbance related to PTSD and traumatic brain injury...
  2. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    ..as a variety of disorders-sleep apnea, parasomnias, REM (rapid eye movement sleep) behavioral disorder (RBD), narcolepsy-many of which are influenced by heredity...
  3. Dopamine Transporter Structure and Function
    Christopher K Surratt; Fiscal Year: 2010
    ..other DAT-related conditions including depression, anxiety disorders, attention deficit hyperactivity disorder, narcolepsy, chronic pain and Parkinson's disease...
  4. Inducible recombination and gene expression in specific neurotransmitter systems
    Steven A Thomas; Fiscal Year: 2012
    ..motivation and reward, and learning and memory, as well as disorders related to these processes that include narcolepsy, drug abuse, anxiety, depression and post- traumatic stress disorder...
  5. Integration of sleep/wake network models across multiple temporal and spatial sca
    ANDREW JOHN PHILLIPS; Fiscal Year: 2013
    ..This sleep/wake switch theory has become the basis for understanding some sleep disorders (e.g., narcolepsy) and the effects of aging on sleep...
  6. Preoptic histamine signaling in thermoregulation and energy expenditure
    IUSTIN VIRGIL TABAREAN; Fiscal Year: 2012
    ..increase the hypothalamic concentration of histamine are beneficial in animal models of diabetes, obesity and narcolepsy, and several such drugs are in clinical trials...
  7. Orexin Receptor Agonists for the Treatment of Excessive Daytime Sleepiness and Ca
    PAUL STUART HUMPHRIES; Fiscal Year: 2013
    ..provided by applicant): Reset Therapeutics proposes to develop orexin receptor agonists for the treatment of narcolepsy. Narcolepsy is a debilitating lifelong disorder characterized by excessive daytime sleepiness (EDS), cataplexy (..
  8. Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and Behavior
    Grigorios Oikonomou; Fiscal Year: 2012
    ..Mutation of the hcrt locus, or loss of hcrt expressing neurons, results in the sleep disorder narcolepsy. Disruption of the LC has been implicated in Parkinson's and Alzheimer's diseases, Down and Rett ..
  9. Functional Anatomy of REM Sleep: Brainstem-Control
    Gerald A Marks; Fiscal Year: 2013
    ..of the mechanisms of REM sleep, which can have a direct impact on several serious sleep disorders such as narcolepsy, REM sleep behavior disorders and REM-related parasomnias...
  10. Hypocretin and its receptors Gene Transfer for Narcolepsy
    Meng Liu; Fiscal Year: 2013
    ..We published the first "proof of principal" paper in narcolepsy gene transfer research area in 2008...
  11. Sleep promotion in zebrafish by hypocretin neuronal networks
    Philippe Mourrain; Fiscal Year: 2012
    ..the hypocretin (hcrt, aka orexin) system, a system involved in the pathophysiology of the sleep disorder narcolepsy, also exists in zebrafish...
  12. Neurobiological studies of gammahydroxybutyrate
    Thomas S Kilduff; Fiscal Year: 2012
    ..both a drug of abuse and, paradoxically, a clinically useful therapeutic for treatment of the sleep disorder narcolepsy. Narcolepsy, a Rapid Eye Movement (REM) sleep-related disorder that afflicts approximately 1 in 1000 Americans, ..
  13. The Role Leptin on Arousal
    PAIGE B BECK; Fiscal Year: 2013
    ..in a number of neuropsychiatric disorders such as schizophrenia, anxiety disorder, bipolar disorder, and narcolepsy. Study of the control of sleep and waking has the potential for making a major impact on a number of disorders, ..
  14. Functional Connectivity of the Hypocretin/Orexin System
    Thomas S Kilduff; Fiscal Year: 2013
    ..Hcrt deficiency results in narcolepsy, a CNS disorder characterized by impaired alertness, excessive sleepiness, restricted social activities, and ..
  15. Transgenic Tethered Peptides
    Michael N Nitabach; Fiscal Year: 2013
    ..Human disorders caused by dysfunction of neuropeptide signaling mechanisms-such as narcolepsy, obesity, addiction, post- traumatic stress disorder, intractable pain, etc-are a major source of morbidity, ..
  16. Development of Small Molecule Orexin Receptor Agonists for Treating Narcolepsy
    Masashi Yanagisawa; Fiscal Year: 2010
    ..to develop and evaluate small-molecule orexin receptor agonists as preclinical leads for the treatment of narcolepsy/cataplexy...
  17. Optogenetic Control of Vigilance State Transition
    Luis de Lecea; Fiscal Year: 2013
    ..Studies in mice, dogs and humans have shown that loss-of- function of the hypocretin system results in narcolepsy/cataplexy...
  18. Development of normal and dystrophic canine iPS lines
    COLIN EDWARD BISHOP; Fiscal Year: 2010
    ..type muscular dystrophy, pyruvate kinase deficiency, muscle type phosphofructokinase deficiency, hemophilia and narcolepsy. More than fifty-eight percent of dog genetic diseases, such as Duchenne-type muscular dystrophy, are true ..
  19. Effects of morphine on the morphology of the hypocretin and MCH systems
    Jerome M Siegel; Fiscal Year: 2013
    ..by applicant): Hypocretin (Hcrt, also called orexin) neurons have been implicated in the pathology underlying narcolepsy. We found that human narcoleptics, on average, have a 90% loss of Hcrt cells...
  20. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David W Carley; Fiscal Year: 2013
    ..Within the PPT, serotonin blunted glutamate-induced respiratory perturbation. Narcolepsy results from a loss of hypothalamic orexinergic neurons that provide excitatory inputs to PPT as well as to ..
  21. Self Organized Criticality as a new paradigm of sleep regulation
    PLAMEN CHRISTOV IVANOV; Fiscal Year: 2013
    ..We will analyze a large database from (i) healthy human subjects, and (ii) subjects with insomnia, narcolepsy, sleep apnea and other disorders;and (iii) from healthy wild type mice and rats...
  22. Neuropeptide modulation of C. elegans light avoidance circuitry
    DEBTIRTHO DIPON GHOSH; Fiscal Year: 2013
    ..Defects in these processes cause serious pathological conditions, including narcolepsy, insomnia, diabetes, obesity, and depression...
  23. Mechanisms that regulate zebrafish Hypocretin neuron development and function
    DAVID AARON PROBER; Fiscal Year: 2013
    ..The identification of defective Hypocretin/Orexin (Hcrt) signaling as a cause of narcolepsy provided a genetic entry point into sleep research, but an effective treatment for this disorder has not yet ..
  24. "Synaptic Modulation of Mesopontine Cholingergic Neurons"
    Christopher S Leonard; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic or intermittent sleep disorders including narcolepsy, REM behavior disorder, sleep apnea, and insomnia afflict nearly 50-70 million people in the United States...
  25. HLA-DQ Sequencing Studies in Narcolepsy/Hypocretin Deficiency
    Emmanuel J Mignot; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Narcolepsy-cataplexy affects 0.05% of the US population. The cause of the disorder is a loss of hypocretin/orexin neurons in the hypothalamus, of likely autoimmune origin...
  26. Regulation of Sleep and Circadian Behaviors by TGF-alpha Signaling
    DANIEL ALLEN LEE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): More than 30 million Americans suffer from chronic sleep disorders such as narcolepsy and insomnia...
  27. Behavioral role of hypocretin (orexin)
    Jerome M Siegel; Fiscal Year: 2013
    ..Behavioral role of hypocretin (orexin) The discovery that loss of hypocretin (Hcrt, orexin) cells causes human narcolepsy has stimulated a great amount of research. However, the normal behavioral role of this peptide remains unclear...
  28. Optogenetic Control of Hypocretin Neurons and Stress
    Luis de Lecea; Fiscal Year: 2013
    ..hypothalamus (LH) are important for maintaining arousal stability since loss of Hcrt function has been linked to narcolepsy in mouse, dog and human subjects...
  29. Mechanisms of Psychostimulant Abuse
    CLAYTON THOMAS BAUER; Fiscal Year: 2013
    ..including amphetamine, are used clinically for treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity, and MARs may also have utility as agonist medications for the treatment of cocaine abuse...
  30. Neuropathology of Hypocretin
    Jerome M Siegel; Fiscal Year: 2013
    ..In work first reported in 2000 and supported entirely by the current grant, we identified the cause of human narcolepsy as a loss of cells containing hypocretin (Hcrt, or orexin)...
  31. Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder with Modafinil
    KATHERINE ELIZABETH BURDICK; Fiscal Year: 2013
    ..US Food and Drug Administration (FDA) for excessive daytime sleepiness associated with several sleep disorders (narcolepsy, sleep apnea, and shift-work disorder)...
  32. TAAR1 Agonists as Narcolepsy Therapeutics
    Thomas S Kilduff; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Narcolepsy afflicts 0.025-0...
  33. The Control of Active (REM) Sleep by the Amygdala
    Michael H Chase; Fiscal Year: 2012
    ..of rational therapies for the treatment of disorders of active sleep including REM Behavior Disorder, narcolepsy/cataplexy, and Restless Legs Syndrome...
  34. Glutamate Receptor Desensitization and its Modulation
    KATHRYN MCKAY PARTIN; Fiscal Year: 2012
    ..reduce cognitive ability, including mild cognitive impairment, Alzheimer's disease, schizophrenia, ADHD, narcolepsy, autism, depression, schizophrenia and Parkinson's disease...
  35. Cellular Signaling in Sleep and Circadian Networks
    Michael N Nitabach; Fiscal Year: 2013
    ..Human disorders caused or exacerbated by impaired regulation of sleep and circadian rhythms-such as narcolepsy, genetic sleep phase disturbances, jet lag, shift work, sleep deprivation, depression, etc-are a major source of ..
  36. Astroglial Orexin in Sleep Disorders
    Priyattam J Shiromani; Fiscal Year: 2013
    ..We have demonstrated the first successful use of neuronal-orexin gene transfer to ameliorate symptoms of narcolepsy in two established animal models of the disease...
  37. HYPOTHALAMIC REGULATION OF SLEEP
    Priyattam J Shiromani; Fiscal Year: 2013
    ..b>Narcolepsy is a neurodegenerative sleep disorder linked to the loss of neurons containing the neuropeptide hypocretin, also ..
  38. Small Molecule Probes of the Neuropeptide S Receptor
    Scott P Runyon; Fiscal Year: 2013
    ..has been linked via its cognate G-protein coupled receptor to a variety of disease states including anxiety, narcolepsy, asthma, obesity, and potentially PTSD...
  39. Selective Activation of Neurons to Control Narcolepsy
    Priyattam J Shiromani; Fiscal Year: 2013
    ..We have focused on narcolepsy, a neurodegenerative sleep disorder linked to the loss of neurons containing the neuropeptide hypocretin, also ..
  40. Neurobehavioral effects of adolescent GHB
    Ratna Sircar; Fiscal Year: 2007
    ..it is used recreationally for its euphoric and anabolic effects, and therapeutically in the treatment of narcolepsy and as an anesthetic agent...
  41. Monoamine Transporter Structure-Function Studies
    CHRISTOPHER SURRATT; Fiscal Year: 2007
    ..conditions including depression, anxiety disorders, attention deficit hyperactivity disorder, migraine, narcolepsy and Parkinson's disease...
  42. OREXIN AND THE CONTROL OF SLEEP AND WAKEFULNESS
    ROBERT MC CARLEY; Fiscal Year: 2005
    ..abstract): Orexins/Hypocretins are newly discovered hypothalamic peptides that studies in canine inherited narcolepsy and mouse knock-out experiments link to cataplexy/narcolepsy, which may be regarded as disorders of REM sleep ..
  43. A Mature Brain Architecture Knowledge Management System
    Larry W Swanson; Fiscal Year: 2012
    ..diseases, including Alzheimer's, chronic pain, epilepsy, multiple sclerosis, Parkinson's, stroke, and narcolepsy. One strength of this approach in early stages of development is that it complements experimental systems ..
  44. The Genetic Basis of Hypocretin Neuronal Specification.
    Justin Liu; Fiscal Year: 2013
    ..Loss of hypocretin neurons causes narcolepsy, an incurable neurological disorder characterized by excessive daytime sleepiness and fragmented sleep/wake ..
  45. Cellular models of hypocretin neuron loss in narcolepsy
    Florian Merkle; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Narcolepsy is a debilitating and incurable sleep disorder that affects 1 in 2000 individuals...
  46. Orexins in Rapid Eye Movement Sleep Control.
    Mahesh Thakkar; Fiscal Year: 2009
    ..There is considerable evidence linking orexins to cataplexy/narcolepsy, which may be regarded as REM sleep disorders...
  47. STATE DEPENDENT CONTROL OF MOTORNEURON ACTIVITY
    Michael Chase; Fiscal Year: 2004
    ..We hypothesize that hypocretin, a newly discovered peptide that has been implicated in the generation of narcolepsy/cataplexy, may be the neurotransmitter that is utilized by the system of reticular response-reversal...
  48. PUPILLOMETRIC SLEEPINESS IN TREATED SLEEP DISORDERS
    Joan Shaver; Fiscal Year: 2003
    Patients with obstructive sleep apnea and narcolepsy can experience a diminished quality of life, decreased productivity, and workplace and traffic accidents due to the pathologic excessive daytime sleepiness (EDS) associated with these ..
  49. MOLECULAR AND BIOCHEMICAL ANALYSIS OF THE CANINE MHC
    John Wagner; Fiscal Year: 2001
    ..Canine models of human diseases have been used to study autoimmune thyroiditis, gluten-sensitive enteropathy, narcolepsy, complement deficiencies, and solid organ and hematopoietic progenitor cell transplants...
  50. THE USE OF ELECTROACUPUNCTURE TO MODULATE AROUSAL
    Edgar Garcia Rill; Fiscal Year: 2002
    ..The amplitude of the P50 potential is decreased in narcolepsy and autism, that is, in diseases in which there appears to be downregulation of the output of the RAS...
  51. AN INDISPENSABLE RESOURCE FOR THE STUDY OF NARCOLEPSY
    William Dement; Fiscal Year: 1993
    The goal of the Center for Narcolepsy research is to unravel the cause of narcolepsy, a genetic disorder of REM sleep affecting approximately 250,000 Americans...
  52. The Roles of Neuropeptide S System in the Regulation of Sleep and Wakefulness
    Yanling Xu; Fiscal Year: 2007
    ..for various sleep disorders or disturbances such as insomnia, excessive daytime sleepiness, sleep apnea and narcolepsy. Neuropeptide S (NPS) and it receptor are a newly discovered neuropeptide system that promotes arousal and ..
  53. CELLULAR BASIS OF BRAINSTEM PGO WAVE GENERATION
    Subimal Datta; Fiscal Year: 2000
    ..The phemomenology and neurochemistry of narcolepsy, cataplexy, excessive daytime sleepiness, hypnogogic hallucinations, depression and many other major psychiatric ..
  54. Hypocretin agonists as treatments for narcolepsy and wakefulness promotion
    THOMAS KILDUFF; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Narcolepsy, a Rapid Eye Movement (REM) sleep-related disorder, is characterized by excessive daytime sleepiness (EDS), cataplexy (a sudden loss of muscle tone triggered by emotional stimulation), and ..
  55. Translational Genetics and Dopamine Signaling in Sensitivity to Amphetamines
    CAMRON BRYANT; Fiscal Year: 2009
    ..used clinically for such conditions as Attention Deficit Hyperactive Disorder, Parkinson's disease, and narcolepsy, studying the genetic basis of the biological actions of these drugs could also lead to improved pharmaceutical ..
  56. SLEEP, AGING, AND THE HYPOCRETIN/OREXIN SYSTEM
    THOMAS KILDUFF; Fiscal Year: 2007
    ..as being important in arousal state regulation, and degeneration of the H/O neurons has been found in human narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and cataplexy...
  57. POSITIONAL CLONING STUDIES OF NARCOLEPSY GENES
    Emmanuel Mignot; Fiscal Year: 2000
    DESCRIPTION (Adapted from the applicant's description) Narcolepsy-cataplexy is a sleep disorder affecting 0.05% of the general population in the US...
  58. Genetic Analysis of Sleep Disorders in Zebrafish
    David Prober; Fiscal Year: 2009
    ..The identification of defective Hypocretin/Orexin (Hcrt) signaling as a cause of narcolepsy provided a genetic entry point into sleep research, but an effective treatment for this disorder has not yet ..
  59. Center for Narcolepsy and Related Disorders (P50)
    Emmanuel J Mignot; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Narcolepsy-cataplexy is a serious and chronic sleep disorder resulting in excessive daytime sleepiness and cataplexy...
  60. BRAINSTEM CHOLINERGIC NEUROANATOMY AND NEUROPHYSIOLOGY
    Priyattam Shiromani; Fiscal Year: 1991
    b>Narcolepsy is a debilitating neurological sleep disorder in which the primary symptoms are excessive daytime sleepiness, sleep attacks, frequent and sudden attacks of cataplexy, and hypnagogic hallucinations...
  61. Hypocretins and Their Role in the Control of Sleep
    RICHARD MAKI; Fiscal Year: 2002
    ..Other sleep disorders include obstructive sleep apnea, restless leg syndrome and narcolepsy. Recently, a mutation in the G-protein coupled receptor hypocretin receptor-2 has been linked to the development ..
  62. Diagnostic Values of Plasma Hypocretin Measures for Sleep Disorders
    Seiji Nishino; Fiscal Year: 2009
    ..goal of this revised proposal is to establish a blood hypocretin measure for a diagnostic test for human narcolepsy. Narcolepsy is a debilitating sleep disorder that affects 1 in 2000 U.S. citizens...
  63. NEUROPHARMACOLOGY OF AROUSAL AND SLEEP DISORDERS
    Yasuko Nakajima; Fiscal Year: 2006
    ..the cellular mechanisms of arousal and sleep with a special emphasis on the pathogenesis of narcolepsy. Hypocretins/orexins, newly discovered peptide neurotransmitters, and their receptors will be studied...
  64. NEUROPHARMACOLOGY OF HUMAN AND CANINE NARCOLEPSY
    Emmanuel Mignot; Fiscal Year: 2000
    ..approach will be used to study the neurochemical control of cataplexy and excessive daytime sleepiness in narcolepsy. In previous funding periods, the investigator has studied the pharmacological control of cataplexy using a ..