disorders of excessive somnolence

Summary

Summary: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)

Top Publications

  1. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
  2. ncbi A new scale for measuring insomnia: the Bergen Insomnia Scale
    Stale Pallesen
    Faculty of Psychology, University of Bergen, Christiesgt 12, 5015 Bergen, Norway
    Percept Mot Skills 107:691-706. 2008
  3. pmc Hypersomnia in inter-episode bipolar disorder: does it have prognostic significance?
    Katherine A Kaplan
    Department of Psychology, University of California, Berkeley, Berkeley, CA, United States
    J Affect Disord 132:438-44. 2011
  4. pmc Insomnia and daytime sleepiness are risk factors for depressive symptoms in the elderly
    Isabelle Jaussent
    INSERM, U1061, Montpellier, F 34000 France
    Sleep 34:1103-10. 2011
  5. pmc Obstructive sleep apnea and risk of motor vehicle crash: systematic review and meta-analysis
    Stephen Tregear
    MANILA Consulting Group, McLean, VA, USA
    J Clin Sleep Med 5:573-81. 2009
  6. ncbi Prevalence and risk factors of subjective sleepiness in the general adult population
    Stale Pallesen
    Department of Psychosocial Science, University of Bergen, Norway
    Sleep 30:619-24. 2007
  7. ncbi Greek version of the Epworth Sleepiness Scale
    Venetia Tsara
    Sleep Unit, GH G PAPANIKOLAOU, Thessaloniki, Greece
    Sleep Breath 8:91-5. 2004
  8. ncbi Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of residual excessive daytime sleepiness in the sleep apnea/hypopnea syndrome
    R N Kingshott
    Sleep Center, Respiratory Medicine Unit, The University of Edinburgh, United Kingdom
    Am J Respir Crit Care Med 163:918-23. 2001
  9. ncbi The socio-economical burden of hypersomnia
    P Jennum
    Department of Clinical Neurophysiology, Danish Centre for Sleep Medicine, University of Copenhagen, Glostrup Hospital, Denmark
    Acta Neurol Scand 121:265-70. 2010
  10. ncbi Shift work and the assessment and management of shift work disorder (SWD)
    Kenneth P Wright
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, 1725 Pleasant Street, Boulder, CO 80309, USA
    Sleep Med Rev 17:41-54. 2013

Detail Information

Publications242 found, 100 shown here

  1. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
    ..ESS scores of patients who simply snored did not differ from controls...
  2. ncbi A new scale for measuring insomnia: the Bergen Insomnia Scale
    Stale Pallesen
    Faculty of Psychology, University of Bergen, Christiesgt 12, 5015 Bergen, Norway
    Percept Mot Skills 107:691-706. 2008
    ..It is one of very few insomnia scales which provide normative data for comparisons and which has been validated against subjective as well as polysomnographic data...
  3. pmc Hypersomnia in inter-episode bipolar disorder: does it have prognostic significance?
    Katherine A Kaplan
    Department of Psychology, University of California, Berkeley, Berkeley, CA, United States
    J Affect Disord 132:438-44. 2011
    ..The current study sought to document the prevalence of hypersomnia in a sample of inter-episode patients with bipolar disorder and to examine the relationship between hypersomnia and future bipolar depressive symptoms...
  4. pmc Insomnia and daytime sleepiness are risk factors for depressive symptoms in the elderly
    Isabelle Jaussent
    INSERM, U1061, Montpellier, F 34000 France
    Sleep 34:1103-10. 2011
    ..However, these associations have not been investigated in community-dwelling elderly taking into account insomnia symptoms, EDS, and sleep medication...
  5. pmc Obstructive sleep apnea and risk of motor vehicle crash: systematic review and meta-analysis
    Stephen Tregear
    MANILA Consulting Group, McLean, VA, USA
    J Clin Sleep Med 5:573-81. 2009
    ..A secondary objective involved determining what factors are associated with an increased motor vehicle crash risk among individuals with OSA...
  6. ncbi Prevalence and risk factors of subjective sleepiness in the general adult population
    Stale Pallesen
    Department of Psychosocial Science, University of Bergen, Norway
    Sleep 30:619-24. 2007
    ..The aim of this study was to investigate the prevalence and risk factors of self-reported excessive daytime sleepiness (EDS) in Norway...
  7. ncbi Greek version of the Epworth Sleepiness Scale
    Venetia Tsara
    Sleep Unit, GH G PAPANIKOLAOU, Thessaloniki, Greece
    Sleep Breath 8:91-5. 2004
    ..The aim of this study was to develop a Greek version of ESS, bearing in mind that language is a barrier for application in non-English speaking populations...
  8. ncbi Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of residual excessive daytime sleepiness in the sleep apnea/hypopnea syndrome
    R N Kingshott
    Sleep Center, Respiratory Medicine Unit, The University of Edinburgh, United Kingdom
    Am J Respir Crit Care Med 163:918-23. 2001
    ..03). This study suggests that modafinil may improve some aspects of alertness in patients with SAHS who remain sleepy during CPAP therapy, but further studies are required to assess the significance of the reduction in CPAP use...
  9. ncbi The socio-economical burden of hypersomnia
    P Jennum
    Department of Clinical Neurophysiology, Danish Centre for Sleep Medicine, University of Copenhagen, Glostrup Hospital, Denmark
    Acta Neurol Scand 121:265-70. 2010
    ..In the absence of socio-economical consequences of hypersomnia this study addresses the factual indirect and direct costs...
  10. ncbi Shift work and the assessment and management of shift work disorder (SWD)
    Kenneth P Wright
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, 1725 Pleasant Street, Boulder, CO 80309, USA
    Sleep Med Rev 17:41-54. 2013
    ....
  11. ncbi Brief report: behaviorally induced insufficient sleep syndrome in older adolescents: prevalence and correlates
    Stale Pallesen
    Department of Psychosocial Science, Faculty of Psychology, University of Bergen, Christiesgt 12, 5015 Bergen, Norway
    J Adolesc 34:391-5. 2011
    ..BIISS was associated with poor grades and symptoms of anxiety and depression...
  12. ncbi The reliability and validity of the Korean version of the Epworth sleepiness scale
    Yong Won Cho
    Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Choon Gu, Daegu, South Korea
    Sleep Breath 15:377-84. 2011
    ..The purposes of this study were to test the hypothesis that the Korean version of the ESS (KESS) is valid and evaluate its usefulness...
  13. ncbi Determinants of excessive daytime sleepiness in a French community-dwelling elderly population
    Norifumi Tsuno
    INSERM Unité 888, Hôpital La Colombière, 39 Avenue Charles Flahault, Montpellier Cedex 5, France
    J Sleep Res 16:364-71. 2007
    ..A multivariate analysis revealed that the lifetime prevalence of manic and hypomanic episodes, snoring and gender (male) were independently associated with EDS. No independent association with other psychiatric disorders was found...
  14. pmc Operational definitions and algorithms for excessive sleepiness in the general population: implications for DSM-5 nosology
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, Stanford University School of Medicine, Palo Alto, CA 94303, USA
    Arch Gen Psychiatry 69:71-9. 2012
    ..Excessive sleepiness (ES) is poorly defined in epidemiologic studies, although its adverse implications for safety, health, and optimal social and vocational functioning have been extensively reported...
  15. ncbi Simplifying STOP-BANG: use of a simple questionnaire to screen for OSA in an Asian population
    Thun How Ong
    Sleep Disorders Unit, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore
    Sleep Breath 14:371-6. 2010
    ..We aim to assess the utility of a simple-to-use 8-point questionnaire in screening for moderate-severe obstructive sleep apnea (OSA) and to assess the validity of cutoffs used to score body mass index (BMI) in this questionnaire...
  16. ncbi Adolescent sleep patterns, circadian timing, and sleepiness at a transition to early school days
    M A Carskadon
    Sleep Research Laboratory, E P Bradley Hospital, E Providence, RI 02915, USA
    Sleep 21:871-81. 1998
    ..This study examined effects on adolescent sleep patterns, sleepiness, and circadian phase of a school transition requiring an earlier start...
  17. ncbi Daytime sleepiness and sleep habits of Australian workers
    M Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Australia
    Sleep 20:844-9. 1997
    ....
  18. ncbi Hypersomnia across mood disorders: a review and synthesis
    Katherine A Kaplan
    Department of Psychology, University of California Berkeley, Berkeley, CA 94720 1650, USA
    Sleep Med Rev 13:275-85. 2009
    ..Though non-pharmacological treatments targeting hypersomnia have not yet been developed, we offer initial guidelines for such treatments and conclude with an agenda for future research...
  19. ncbi A case-control study on excessive daytime sleepiness in episodic migraine
    P Barbanti
    Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele, via della Pisana 235, 00163 Rome, Italy
    Cephalalgia 27:1115-9. 2007
    ..EDS correlated with migraine disability, sleep problems and anxiety. EDS in patients with migraine probably stems from the full constellation of headache-sleep-affective symptoms resulting from the complex clinical burden of the disease...
  20. ncbi Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing
    Ma Cecilia S Melendres
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatrics 114:768-75. 2004
    ..Furthermore, we hypothesized that overnight polysomnographic parameters correlated with sleepiness and hyperactivity...
  21. pmc Pain coping strategies for tension-type headache: possible implications for insomnia?
    Jason C Ong
    Sleep Disorders Service and Research Center, Department of Behavioral Sciences, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612 3833, USA
    J Clin Sleep Med 5:52-6. 2009
    ..The present study examined pain-related self-management strategies in a nonclinical, young-adult sample for preliminary evidence to support a novel hypothesis for the development of insomnia in this population...
  22. pmc Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep
    Emilie Sapin
    CNRS, UMR5167, Physiopathologie des réseaux neuronaux du cycle veille sommeil, Lyon, France
    PLoS ONE 4:e4272. 2009
    ..From these results, we propose a revised model for PS control in which GABAergic PS-on and PS-off neurons localized in the vlPAG/dDPMe region play leading roles...
  23. ncbi Excessive daytime sleepiness among the Japanese general population
    Yoshitaka Kaneita
    Department of Public Health, School of Medicine, Nihon University, Tokyo, Japan
    J Epidemiol 15:1-8. 2005
    ..However, there are few epidemiologic studies on excessive daytime sleepiness in a large scale sample targeting Japanese general population...
  24. ncbi The Epworth Sleepiness Scale: influence of age, ethnicity, and socioeconomic deprivation. Epworth Sleepiness scores of adults in New Zealand
    Philippa H Gander
    Sleep Wake Research Centre, Research School of Public Health, Massey University, Wellington, New Zealand
    Sleep 28:249-53. 2005
    ..To examine possible relationships between excessive sleepiness (Epworth Sleepiness Scale score >10), and age, sex, ethnicity, socioeconomic deprivation, usual sleep, and self-reported symptoms of obstructive sleep apnea...
  25. ncbi Excessive daytime sleepiness and risk of occupational injuries in non-shift daytime workers
    Samuel Melamed
    Occupational Health Psychology Department, National Institute of Occupational and Environmental Health, Raanana, Israel
    Sleep 25:315-22. 2002
    ..This study tested this association in daytime workers using injury data taken from organizational archives...
  26. ncbi Sleep and reported daytime sleepiness in normal subjects: the Sleep Heart Health Study
    Joyce A Walsleben
    Department of Pulmonary and Critical Care, New York University School of Medicine, USA
    Sleep 27:293-8. 2004
    ..To describe the distribution of nocturnal sleep characteristics and reports of daytime sleepiness in a large well-defined group of healthy adults...
  27. ncbi Excessive daytime sleepiness: a challenge for the practising neurologist
    C Guilleminault
    Stanford Sleep Disorders Clinic, Stanford Hospital and Clinics, Stanford University and Medical Centre, Stanford, California 94305, USA
    Brain 124:1482-91. 2001
    ..As our understanding of the neurological underpinnings of alertness and sleepiness deepens, improved treatment methods are bound to emerge...
  28. ncbi Health-related quality of life in Italian patients with narcolepsy: the SF-36 health survey
    Luca Vignatelli
    Dipartimento di Scienze Neurologiche, Universita degli Studi di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy
    Sleep Med 5:467-75. 2004
    ..To compare the HRQoL of patients with narcolepsy with the Italian norm. To disclose the clinical predictors influencing the HRQoL...
  29. ncbi Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study
    James B Lohr
    Department of Psychiatry, University of California, San Diego UCSD, La Jolla, CA, USA Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA Electronic address
    Schizophr Res 150:289-96. 2013
    ....
  30. pmc From wakefulness to excessive sleepiness: what we know and still need to know
    MAURICE MOYSES OHAYON
    Stanford Sleep Epidemiology, School of Medicine, Stanford University, 3430 W Bayshore Road, Palo Alto, CA, USA
    Sleep Med Rev 12:129-41. 2008
    ..Inconsistencies in its definition and measurement limit the generalization of the results. The use of a single question fails to capture the complexity of the symptom. The natural evolution of hypersomnia remains to be documented...
  31. ncbi Atypical antipsychotics: sedation versus efficacy
    John M Kane
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    J Clin Psychiatry 69:18-31. 2008
    ....
  32. ncbi Odds, prevalence and predictors of sleep problems in school-age normal children
    Karen Spruyt
    Department of Cognitive and Physiological Psychology, Faculty of Psychology and Educational Sciences, Free University of Brussels, Brussels, Belgium
    J Sleep Res 14:163-76. 2005
    ..These results suggest that disorders of excessive somnolence (DES) are highly prevalent in a non-clinical sample of school-age children...
  33. pmc Idiopathic hypersomnia with and without long sleep time: a controlled series of 75 patients
    Cyrille Vernet
    Unité des pathologies du sommeil, Hopital Pitie Salpetriere, Paris, France
    Sleep 32:753-9. 2009
    ..To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography...
  34. ncbi Increased daytime somnolence despite normal sleep patterns in patients treated for nonfunctioning pituitary macroadenoma
    Agatha A van der Klaauw
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 92:3898-903. 2007
    ..Because this may be related to altered sleep patterns, we evaluated daytime sleepiness and sleep patterns in patients successfully treated for NFMA in our center...
  35. ncbi Underlying sleep pathology may cause chronic high fatigue in shift-workers
    J L Hossain
    Sleep Research Laboratory, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Sleep Res 12:223-30. 2003
    ..It is concluded that chronic high fatigue can be an independent manifestation of underlying sleep pathology, which warrants independent subjective and objective assessment...
  36. ncbi Excessive daytime sleepiness in psychiatric disorders: Prevalence, correlates and clinical significance
    Chris J Hawley
    Department of Psychiatry, QEII Hospital, Hertfordshire Partnership NHS Trust, Howlands, Welwyn Garden City, Hertfordshire, AL7 4HQ, UK
    Psychiatry Res 175:138-41. 2010
    ..The data suggest that excessive daytime sleepiness is a significant issue in general adult psychiatry, but this must be interpreted against a relatively high prevalence in the normal population...
  37. ncbi Excessive daytime sleepiness in multiple system atrophy (SLEEMSA study)
    Claudia Moreno-López
    Movement Disorders Unit, Department of Neurology, Hospital Clinic of Barcelona, University of Barcelona Medical School and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, 08036 Barcelona, Spain
    Arch Neurol 68:223-30. 2011
    ..Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known...
  38. ncbi [Narcolepsy and other hypersomnias]
    Trond Sand
    Institutt for nevromedisin, Norges teknisk naturvitenskapelige universitet og Avdeling for nevrologi og klinisk nevrofysiologi, St Olavs Hospital, 7006 Trondheim, Norway
    Tidsskr Nor Laegeforen 129:2007-10. 2009
    ..Many patients with hypersomnia are diagnosed too late. The article presents a review of this field...
  39. pmc Modification of the Epworth Sleepiness Scale in Central China
    Jin Nong Zhang
    Department of Respiratory Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022 Wuhan, People s Republic of China
    Qual Life Res 20:1721-6. 2011
    ..This study is aimed to build a modified ESS (mESS) and then to verify its feasibility in the assessment of EDS for patients with suspected sleep-disordered breathing (SDB) in central China...
  40. ncbi The prevalence of multiple sleep-onset REM periods in a population-based sample
    Meeta Singh
    Henry Ford Sleep Disorders Center, Detroit, MI 48202, USA
    Sleep 29:890-5. 2006
    ..The present study determined the prevalence of 2 or more SOREMPs in a representative sample of the population from southeast Michigan and investigated potential associations with other sleep-related variables...
  41. pmc A 2-week, polysomnographic, safety study of sodium oxybate in obstructive sleep apnea syndrome
    Charles F P George
    University of Western Ontario, London Health Sciences Centre, 375 South Street, London, ON, N6A 4G5, Canada
    Sleep Breath 15:13-20. 2011
    ..Obstructive sleep apnea syndrome (OSAS) affects ∼9-50% of narcoleptics. Effects of 2-week SXB administration on apnea-hypopnea index (AHI), oxygen saturation (SaO(2)), and sleep architecture were investigated in OSAS patients...
  42. ncbi Sleepiness in patients with moderate to severe sleep-disordered breathing
    Vishesh K Kapur
    Department of Medicine, University of Washington Sleep Disorders Center, Box 359803, 325 Ninth Avenue, Seattle, WA 98104, USA
    Sleep 28:472-7. 2005
    ..We investigated the prevalence of sleepiness as well as factors associated with sleepiness in individuals with moderate to severe sleep-disordered breathing (apnea-hypopnea index > or = 15)...
  43. ncbi Narcolepsy, metabolic syndrome and obstructive sleep apnea syndrome as the causes of hypersomnia in children. Report of three cases
    J Wasilewska
    III Department of Pediatrics, Medical University of Białystok, Poland
    Adv Med Sci 52:207-11. 2007
    ..7/h in October 2005 to 2.9/h in October 2006. Within that time his parents did not observe any episodes of daytime sleepiness, irritability or nocturnal enuresis...
  44. ncbi Prevalence of excessive daytime sleepiness and associated factors in the adult population of Korea
    SoonJae Joo
    Institute of Human Genomic Study, Korea University Medical Center, Ansan Hospital, Gyeonggi Do, Republic of Korea
    Sleep Med 10:182-8. 2009
    ..Information on the prevalence and correlates of excessive daytime sleepiness (EDS) is limited for Asians. We determined the prevalence of EDS and its associated factors in the adult population of Korea...
  45. ncbi Differences in nocturnal and daytime sleep between primary and psychiatric hypersomnia: diagnostic and treatment implications
    A N Vgontzas
    Sleep Research and Treatment Center and Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Psychosom Med 62:220-6. 2000
    ..The aim of this study was to assess whether polysomnography aids in the differential diagnosis of these two disorders...
  46. ncbi Differences between minimally depressed patients who do and do not consider themselves to be in remission
    Mark Zimmerman
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02905, USA
    J Clin Psychiatry 66:1134-8. 2005
    ....
  47. ncbi Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance
    J L Newton
    Care of the Elderly Offices, Royal Victoria Infirmary, Newcastle NE1 4LP, UK
    Gut 57:807-13. 2008
    ..To quantify fatigue in non-alcoholic fatty liver disease (NAFLD), to determine whether perceived fatigue reflects impairment of physical function and to explore potential causes...
  48. ncbi Subjective fatigue and subjective sleepiness: two independent consequences of sleep disorders?
    Jamil L Hossain
    Sleep Research Unit and Department of Psychiatry, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Sleep Res 14:245-53. 2005
    ..Furthermore, predominantly fatigued individuals with sleep disorders seem vulnerable to additional negative consequences due to possible interplay between amplified fatigue and psychological distress...
  49. pmc Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning
    Terri E Weaver
    Biobehavioral and Health Sciences Division, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Sleep 30:711-9. 2007
    ..This study, employing probit analyses and piecewise regression to estimate dose-response functions, estimated likelihoods of return to normal levels of sleepiness and daily functioning relative to nightly duration of CPAP...
  50. ncbi Variability in the Epworth sleepiness scale score between the patient and the partner
    Hatice Kumru
    Department of Neurology, Hospital Clínic of Barcelona and the Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Villarroel 170, Barcelona 08036, Spain
    Sleep Med 5:369-71. 2004
    ..We investigated the agreement between patient and partner perceptions of the patient's sleepiness...
  51. pmc Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin
    Timothy I Morgenthaler
    Mayo Clinic, Rochester MN, USA
    Sleep 30:1705-11. 2007
    ....
  52. pmc Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study
    Charles A Czeisler
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mayo Clin Proc 84:958-72. 2009
    ....
  53. ncbi Evaluation of positive airway pressure treatment for sleep related breathing disorders in adults
    Peter Gay
    Mayo Clinic, Rochester, MN 55905, USA
    Sleep 29:381-401. 2006
    ..Finally, the use of bilevel PAP therapy is reviewed for both patients with OSA and those with other selected nocturnal breathing disorders. Each section also contains a brief summary and suggestions for future research...
  54. ncbi Excessive daytime sleepiness in Parkinson's disease as assessed by Epworth Sleepiness Scale (ESS)
    Suresh Kumar
    Department of Neurology, All India Institute of Medical Sciences, New Delhi 110029, India
    Sleep Med 4:339-42. 2003
    ..To assess daytime sleepiness in patients with Parkinson's disease (PD) using the Epworth Sleepiness Scale (ESS)...
  55. ncbi Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test
    Michael R Littner
    VA Greater Los Angeles Healthcare System, CA, USA
    Sleep 28:113-21. 2005
    ..These practice parameters also include recommendations for the MSLT and MWT protocols, a discussion of the normative data available for both tests, and a description of issues that need further study...
  56. pmc A very large number of GABAergic neurons are activated in the tuberal hypothalamus during paradoxical (REM) sleep hypersomnia
    Emilie Sapin
    CNRS, UMR5167, Physiopathologie des réseaux neuronaux du cycle veille sommeil, Universite Claude Bernard Lyon 1, Universite de Lyon, Lyon, France
    PLoS ONE 5:e11766. 2010
    ..Further investigations will be needed to corroborate this original hypothesis...
  57. pmc Excessive daytime sleepiness in migraine patients
    M F P Peres
    J Neurol Neurosurg Psychiatry 76:1467-8. 2005
  58. ncbi Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale
    Bilgay Izci
    Department of Sleep Medicine, University of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland, UK
    Sleep Breath 12:161-8. 2008
    ..The ESStr is a reliable and valid measure of daytime sleepiness. These features and the simplicity of the ESStr make it a valuable measure for clinical management and research...
  59. ncbi Correlates of daytime sleepiness in 4578 elderly persons: the Cardiovascular Health Study
    C W Whitney
    Department of Biostatistics, University of Washington, Seattle, USA
    Sleep 21:27-36. 1998
    ..Surprisingly, anatomic abnormalities such as evidence of previous strokes and brain atrophy (as seen on brain MRI scans) were not associated with daytime sleepiness in these non-institutionalized elderly persons...
  60. ncbi [Excessive daytime sleepiness]
    Lia Rita Azeredo Bittencourt
    Universidade Federal de Sao Paulo
    Rev Bras Psiquiatr 27:16-21. 2005
    ....
  61. ncbi Modafinil for excessive sleepiness associated with shift-work sleep disorder
    Charles A Czeisler
    Division of Sleep Medicine, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 353:476-86. 2005
    ..Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder...
  62. ncbi Risks of high-dose stimulants in the treatment of disorders of excessive somnolence: a case-control study
    R Robert Auger
    Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, MN, USA
    Sleep 28:667-72. 2005
    ..To ascertain complications associated with high-dose stimulant therapy in patients with narcolepsy or idiopathic hypersomnia...
  63. ncbi Habitual snoring, intermittent hypoxia, and impaired behavior in primary school children
    Michael S Urschitz
    Department of Neonatology, University Children s Hospital, Tuebingen, Germany
    Pediatrics 114:1041-8. 2004
    ..We aimed to determine the extent of behavioral problems in snoring children, clarify the role of intermittent hypoxia, and test the reversibility of impaired behavior and poor academic performance...
  64. ncbi Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats
    Lucie Hanriot
    Centre National de Recherche Scientifique UMR5167, Universite de Lyon, Université Lyon1, Institut Federatif des Neurosciences de Lyon, Lyon, 69372, France
    J Comp Neurol 505:147-57. 2007
    ..Based on these results and the literature, we propose that MCH could be involved in memory processes and in the inhibition of muscle tone during PS...
  65. ncbi Randomized placebo-controlled trial of pantoprazole for daytime sleepiness in GERD and obstructive sleep disordered breathing
    Maria V Suurna
    Department of Otolaryngology, Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0528, USA
    Otolaryngol Head Neck Surg 139:286-90. 2008
    ..To determine the efficacy of pantoprazole therapy for daytime somnolence, psychomotor vigilance, and quality of life in patients with mild-moderate obstructive sleep disordered breathing (OSDB) and gastroesophageal reflux disease (GERD)...
  66. pmc CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions
    Y Dauvilliers
    Service de Neurologie B, Hopital Gui de Chauliac, Montpellier, France
    J Neurol Neurosurg Psychiatry 74:1667-73. 2003
    ..To determine the role of CSF hypocretin-1 in narcolepsy with and without cataplexy, Kleine-Levin syndrome (KLS), idiopathic and other hypersomnias, and several neurological conditions...
  67. ncbi Confirmatory factor analysis of the Epworth Sleepiness Scale (ESS) in patients with obstructive sleep apnoea
    Simon S Smith
    School of Psychology, The University of Queensland, St Lucia, QLD 4072, Australia
    Sleep Med 9:739-44. 2008
    ..Its psychometric properties are still unclear, particularly when used to evaluate sleep propensity in patients with obstructive sleep apnoea...
  68. ncbi Clinical reproducibility of the Epworth Sleepiness Scale
    Anh Tu Duy Nguyen
    Mount Sinai Hospital, Montreal, Canada
    J Clin Sleep Med 2:170-4. 2006
    ..The Epworth Sleepiness Scale (ESS) is widely used as a subjective measure of sleepiness. To our knowledge, no study has evaluated its reproducibility in the clinical setting...
  69. ncbi Severity of gastroesophageal reflux disease influences daytime somnolence: a clinical study of 134 patients underwent upper panendoscopy
    Pal Demeter
    St John s Hospital, Outpatient Clinic of Gastroenterology, Szoloskertut 7, Budakeszi 2092, Hungary
    World J Gastroenterol 10:1798-801. 2004
    ..To asses the relationship between severity of gastroesophageal refluxe disease and Epworth sleepiness scale as an indicator of daytime somnolence...
  70. ncbi Why do we continue to use Epworth sleepiness scale?
    Naoko Tachibana
    Sleep Med 8:541-2. 2007
  71. ncbi The Epworth sleepiness scale: relationship to sleep and mental disorders in a sleep clinic
    Kent J DeZee
    Department of Medicine, William Beaumont Army Medical Center, 5005 N Piedras Street, El Paso, TX 79920 5001, USA
    Sleep Med 7:327-32. 2006
    ..We sought to assess the relationship between the ESS scores and mental disorders in a sleep clinic...
  72. ncbi A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness
    Seung Chul Hong
    Department of Neuropsychiatry, St Vincent s Hospital, Catholic University of Korea, Suwon, Korea
    Sleep 29:1429-38. 2006
    ....
  73. ncbi Differential diagnosis in hypersomnia
    Yves Dauvilliers
    Neurology Department, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, INSERM E0361 34295, Montpellier, Cedex 5, France
    Curr Neurol Neurosci Rep 6:156-62. 2006
    ....
  74. ncbi The association of sleep-disordered breathing and sleep symptoms with quality of life in the Sleep Heart Health Study
    C M Baldwin
    Department of Medicine, University of Arizona, Tucson 85724 5030, USA
    Sleep 24:96-105. 2001
    ..S. general population...
  75. ncbi Clinical significance and correlates of behaviorally induced insufficient sleep syndrome
    Yoko Komada
    Japan Somnology Center, Neuropsychiatric Research Institute, Shibuya, Tokyo, Japan
    Sleep Med 9:851-6. 2008
    ..The aim of this study was to investigate the demographic variables and clinical characteristics of behaviorally induced insufficient sleep syndrome (BIISS) and to compare it with the other major hypersomnia disorders...
  76. ncbi Distinguishing sleepiness and fatigue: focus on definition and measurement
    Jianhua Shen
    Sleep Research Laboratory, Department of Psychiatry, University Health Network and University of Toronto, 399 Bathurst Street, 7M 417, Toronto, Ont, Canada M5T 2S8
    Sleep Med Rev 10:63-76. 2006
    ..Despite a high prevalence and high degree of morbidity, fatigue has remained a relatively under appreciated symptom, from both a clinical and research point of view...
  77. ncbi What are the important risk factors for daytime sleepiness and fatigue in women?
    Jenny Theorell-Haglöw
    Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Sweden
    Sleep 29:751-7. 2006
    ..To analyze the relation between different risk factors and excessive daytime sleepiness (EDS) and fatigue in women from a general-population sample...
  78. ncbi Subjective daytime sleepiness: dimensions and correlates in the general population
    Hyon Kim
    Department of Population, Health Sciences, University of Wisconsin Madison, 1300 University Ave MSC Rm 1022, Madison, WI 53706, USA
    Sleep 28:625-34. 2005
    ....
  79. ncbi Sleep health New South Wales: chronic sleep restriction and daytime sleepiness
    D J Bartlett
    Woolcock Institute of Medical Research and the National Health and Medical Research Council of Australia Centre for Respiratory and Sleep Medicine, Sydney, New South Wales, Australia
    Intern Med J 38:24-31. 2008
    ..The aim of this study was to provide the first population-based descriptions of typical sleep duration and the prevalence of chronic sleep restriction and chronic sleepiness in community-dwelling Australian adults...
  80. ncbi Modafinil for treatment of residual excessive sleepiness in nasal continuous positive airway pressure-treated obstructive sleep apnea/hypopnea syndrome
    Jed E Black
    Stanford Sleep Disorder Clinic, Stanford University, Stanford, CA 94305, USA
    Sleep 28:464-71. 2005
    ..We evaluated the efficacy and safety of the wake-promoting agent modafinil for treating residual excessive sleepiness in nCPAP-treated patients...
  81. pmc Hypersomnia
    Yves Dauvilliers
    Service de Neurologie B, , INSERM E0361, Montpellier, France
    Dialogues Clin Neurosci 7:347-56. 2005
    ....
  82. ncbi Insomnia and hypersomnia associated with depressive phenomenology and comorbidity in childhood depression
    Xianchen Liu
    Department of Psychiatry, University of Pittsburgh School of Medicine and WPIC, PA 15213, USA
    Sleep 30:83-90. 2007
    ....
  83. ncbi Effects of armodafinil in the treatment of residual excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome: a 12-week, multicenter, double-blind, randomized, placebo-controlled study in nCPAP-adherent adults
    Thomas Roth
    Henry Ford Sleep Disorders Center, Detroit, Michigan 48202, USA
    Clin Ther 28:689-706. 2006
    ..Some patients with obstructive sleep apnea/hypopnea syndrome (OSA/HS) experience excessive sleepiness (ES) that might not resolve with nasal continuous positive airway pressure (nCPAP) treatment...
  84. ncbi Difference in the characteristics of subjective and objective sleepiness between narcolepsy and essential hypersomnia
    Yoko Komada
    National Institute of Mental Health, National Center of Neurology and Psychiatry, 1 7 3 Kohnodai, Ichikawa, Chiba 272 0827, Japan
    Psychiatry Clin Neurosci 59:194-9. 2005
    ..It is suggested that the mild disease severity of essential hypersomnia contributed to the formation of these characteristics...
  85. pmc Sleep. 4: Sleepiness, cognitive function, and quality of life in obstructive sleep apnoea/hypopnoea syndrome
    H M Engleman
    Edinburgh Sleep Centre, Unit of Respiratory Medicine, University of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, Scotland, UK
    Thorax 59:618-22. 2004
    ..The evidence is compatible with hypotheses that these deficits are reversible with treatment, particularly for patients with severe disease...
  86. ncbi Association of sleep and academic performance
    Arne Eliasson
    12515 Davan Drive, Silver Spring, MD 20904, USA
    Sleep Breath 6:45-8. 2002
    ..Before mandating costly changes in school schedules, it would be useful to perform further research to determine the effects of increasing sleep time on the behaviors of adolescent students...
  87. ncbi Excessive sleepiness in adolescents and young adults: causes, consequences, and treatment strategies
    Richard P Millman
    Pediatrics 115:1774-86. 2005
    ....
  88. ncbi Popular media and 'excessive daytime sleepiness': a study of rhetorical authority in medical sociology
    Steve Kroll-Smith
    Department of Sociology, University of North Carolina at Greensboro, 27402, USA
    Sociol Health Illn 25:625-43. 2003
    ..A limited case for this claim is made by revisiting two key ideas in this field: naming diseases and the classic distinction between illness and disease...
  89. ncbi [An estimation of the prevalence of excessive daytime sleepiness based on age and sex distribution of epworth sleepiness scale scores: a population based survey]
    Misa Takegami
    Kyoto University, Graduate School of Medicine, School of Public Health, Department of Epidemiology and Healthcare Research
    Nihon Koshu Eisei Zasshi 52:137-45. 2005
    ..To describe the distribution of subjective daytime sleepiness among local residents using the Epworth Sleepiness Scale (ESS) and estimate the prevalence of excessive daytime sleepiness (EDS) in a general Japanese adult population...
  90. ncbi Evaluation of chronic insomnia. An American Academy of Sleep Medicine review
    M J Sateia
    Sleeps Disorders Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
    Sleep 23:243-308. 2000
    ..Thorough assessment also requires attention to the unique aspects of presentation and specific set of etiologies which are associated with particular age groups...
  91. ncbi Conditions of primary excessive daytime sleepiness
    Jed E Black
    Stanford Sleep Disorders Center, Sleep Medicine Division, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Neurol Clin 23:1025-44. 2005
    ..Several methods have been developed to assess EDS, although each of them has limitations. Treatment is available for the great majority of cases...
  92. ncbi Menstrual-associated sleep disorder: an unusual hypersomniac variant associated with both menstruation and amenorrhea with a possible link to prolactin and metoclopramide
    C R Bamford
    Department of Neurology, University of Arizona, Tucson
    Sleep 16:484-6. 1993
    ..The hypersomnolence, however, did not abate, but rather became more brief and erratic in its periodicity. The hypersomnolence was associated with marked elevations in the serum prolactin level...
  93. ncbi The clinical use of the MSLT and MWT
    Donna Arand
    Kettering Medical Center Dayton, OH, USA
    Sleep 28:123-44. 2005
    ..Additionally the presence of two or more SOREMPs on the MSLT is a common finding in narcolepsy patients. However, SOREMPs are not exclusive to narcolepsy patients but are frequent in untreated sleep apnea..
  94. ncbi Modafinil improves alertness, vigilance, and executive function during simulated night shifts
    James K Walsh
    Sleep Medicine and Research Center, affiliated with St John s Mercy Medical Center and St Luke s Hospital, St Louis, Missouri, USA
    Sleep 27:434-9. 2004
    ..To assess the effect of 200 mg of modafinil compared to placebo on alertness, neurobehavioral performance, and executive function during 4 consecutive simulated night shifts...
  95. ncbi Reverse sleep state misperception
    Hrayr P Attarian
    Department of Neurology, Vermont Regional Sleep Medicine Center, C N L Patrick 5, 111 Colchester Ave, Burlington, VT 05401, USA
    Sleep Med 5:269-72. 2004
    ..This patient may have a previously undescribed variation of sleep state misperception that the authors have tentatively named 'reverse' sleep state misperception...
  96. ncbi Effect of a targeted obstructive sleep apnea consult to improve access and quality at a sleep disorders center
    Timothy I Morgenthaler
    Mayo Clinic Sleep Disorders Center, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Sleep Med 2:49-56. 2006
    ....
  97. ncbi Relationship between sleep apnoea syndrome, snoring and headaches
    J P Neau
    Institut Universitaire Veille Sommeil, Faculte de Medecine et Pharmacie, Poitiers, Department of Neurology, CHU La Miletrie, Poitiers, France
    Cephalalgia 22:333-9. 2002
    ..Despite this absence of specificity, the treatment of SAS, especially nasal continuous positive airway pressure, leads to an improvement in headaches in several cases...
  98. ncbi Vulnerability to stress-related sleep disturbance and hyperarousal
    Christopher Drake
    Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
    Sleep 27:285-91. 2004
    ..To determine the presence of a hypothesized trait vulnerability to sleep disturbance and hyperarousal...
  99. ncbi Outcome of sleepiness and fatigue scores in obstructive sleep apnea syndrome patients with and without restless legs syndrome after nasal CPAP
    Raimundo Nonato Delgado Rodrigues
    Hospital Universitario de Brasilia, 70844 010 Brasília, DF, Brazil
    Arq Neuropsiquiatr 65:54-8. 2007
    ..The primary concern of this study is to evaluate the outcome of fatigue and daytime sleepiness symptoms at baseline and after continuous positive air pressure (CPAP) treatment in OSAS patients with and without RLS...
  100. ncbi The role of sleep-disordered breathing, daytime sleepiness, and impaired performance in motor vehicle crashes-a case control study
    Ruth N Kingshott
    Department of Respiratory Research, University of Otago, Dunedin, New Zealand
    Sleep Breath 8:61-72. 2004
    ..To examine levels of sleep-disordered breathing, daytime sleepiness, and impaired performance in 60 motor vehicle crash drivers and 60 controls matched for age, gender, and body mass index...
  101. ncbi Daytime impairment and neurodegeneration in OSAS
    Magdalena Nowak
    Department of Psychiatry, University of Erlangen, Germany
    Sleep 29:1521-30. 2006
    ..We propose the existence of a neurodegenerative process...

Research Grants69

  1. DAYTIME SLEEPINESS--PREVALENCE, CONSEQUENCES, AND RISKS
    Thomas Roth; Fiscal Year: 2003
    ..The important contribution of the present proposal is that it will be the first population-based study to use laboratory assessments, its consequences and risks to measure sleepiness. ..
  2. Spectrum of Narcolepsy in the Probands Families
    MAURICE OHAYON; Fiscal Year: 2007
    ..A blood sample (3-5 ml) will be asked also to all participants. This will allow us to link some genetic markers of narcolepsy to specific symptoms even in subjects without the full-fledge manifestation of the disease. ..
  3. Predisposition Model of Insomnia
    Christopher Drake; Fiscal Year: 2008
    ..abstract_text> ..
  4. Impact of sleepiness on heart failure self-care
    Barbara Riegel; Fiscal Year: 2009
    ..This study is expected to expand existing knowledge and clarify our understanding of the mechanisms linking EDS, failed self-care, poor HRQL, and unplanned hospitalizations in persons with heart failure. ..
  5. Impact of CPAP on Functional Outcomes in Milder OSA
    Terri Weaver; Fiscal Year: 2006
    ..Secondary aims of the study are: 1) to examine whether CPAP also improves daytime sleepiness; 2) to determine whether CPAP can reduce nocturnal blood pressure to lower the risk for stroke and hypertension linked to OSA. ..
  6. Obstructive Sleep Apnea (OSA) in obese teens & preteens: Neurobahavioral effects
    Dean Beebe; Fiscal Year: 2008
    ..abstract_text> ..
  7. SLEEP/DOPAMINE PHENOTYPES IN GENETICALLY DISTINCT MICE
    David Rye; Fiscal Year: 2002
    ..abstract_text> ..
  8. BRAINSTEM SUBSTRATES OF DOPAMINE MODULATED MOVEMENTS
    David Rye; Fiscal Year: 2002
    ..g., OCD, ADD, Tourette's and schizophrenia, the results will also bear relevance to a wider spectrum of disease. ..
  9. Circuitry of Midbrain Dopamine in Sleep & Wake
    David Rye; Fiscal Year: 2005
    ..g., schizophrenia) and hypodopaminergic (e.g., PD and restless legs/periodic leg movements of sleep). ..
  10. SLEEPINESS AND THE REINFORCING EFFECT OF METHYLPHENIDATE
    Timothy Roehrs; Fiscal Year: 2002
    ..And finally during year five the interaction of behavioral demand placed on subjects and different levels of sleepiness-alertness will be the focus. ..
  11. S-Adenosyl Methionine(SAMe)Augmentation of SSRIs in MDD
    George Papakostas; Fiscal Year: 2008
    ..It is hoped that this project award will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator in this area. ..
  12. Role of hypocretin/histamine in Narcolepsy/EDS disorders
    Seiji Nishino; Fiscal Year: 2009
    ..We believe that results from these studies will bring new insights regarding the roles of the hypocretin/histamine interaction in narcolepsy and other EDS disorders and better treatment modalities in humans. ..
  13. Insomnia as a Path to Alcohol Abuse
    Timothy Roehrs; Fiscal Year: 2005
    ..abstract_text> ..
  14. Role of Histamine in Narcolepsy/EDS Disorders
    Seiji Nishino; Fiscal Year: 2008
    ..As almost nothing is known on the pathophysiology of non- hypocretin deficient hypersomnias, we believe this work to be ideally suited for a small grant application. [unreadable] [unreadable] [unreadable]..
  15. Abuse Liability Associated with Chronic Hypnotic Use
    Timothy Roehrs; Fiscal Year: 2008
    ....
  16. PHARMACOLOGICAL STUDIES OF HUMAN AND CANINE NARCOLEPSY
    Seiji Nishino; Fiscal Year: 2002
    ....
  17. Phase Preference, Sleepiness, and Adolescent Development
    MARY CARSKADON; Fiscal Year: 2005
    ..Finally, Study 3 is a pilot study to assess whether intrinsic period is shorter in adolescents with morning than evening phase preference, as has been reported in adults...
  18. Alcohol, Sleep and Circadian Rhythms in Young Humans
    MARY CARSKADON; Fiscal Year: 2005
    ..Study 3 involves a total of 24 FH- participants. ..
  19. THE ROLE OF CYTOKINES IN SLEEPINESS AND SLEEP APNEA
    Alexandros Vgontzas; Fiscal Year: 2009
    ..These studies collectively will provide additional evidence for a role of TNFa and IL-6 in EDS and OSA and lay the foundation for the development of novel therapeutic interventions. ..
  20. Sleep Apnea: Upper Airway Nerve Injury
    Sigrid Veasey; Fiscal Year: 2009
    ..Collectively, the proposed studies will unveil important mechanisms of neuronal injury in obstructive sleep apnea and should reveal diabetes is a risk factor for this neural injury in sleep apnea. ..
  21. Workshop to Consider the Feasibility of a Sleep/Circadian Rhythms Gene Chip
    MARY CARSKADON; Fiscal Year: 2007
    ..The workshop will also examine other methods and techniques that may help advance the genetic study of sleep and sleep disorders. [unreadable] [unreadable] [unreadable]..
  22. Controlled Study of SAMe vs.Escitalopram in Major Depressive Disorder
    Maurizio Fava; Fiscal Year: 2008
    ..Secondary aims are to assess the acute effects of SAMe or escitalopram vs. placebo on remission rates, quality of life, and psychosocial functioning. ..
  23. ADOLESCENT SLEEP: CIRCADIAN AND HOMEOSTATIC PROCESSES
    MARY CARSKADON; Fiscal Year: 2003
    ..On the basis of these hypotheses, explanations for developmental changes in the bioregulatory processes affecting sleep may be elucidated, with the hope that more complex adolescent behaviors may eventually be understood. ..
  24. BUPROPION AS AN ADJUNCT TO THE NICOTINE PATCH PLUS CBT
    Maurizio Fava; Fiscal Year: 2003
    ....
  25. Adolescent ADHD: Sleep, Symptoms, and Medication
    Gahan Fallone; Fiscal Year: 2003
    ..Further, under conditions of restricted sleep, we predict that adolescents with ADHD will show increased sleepiness, increased ADHD symptom severity, and increased perceived need for psychostimulant medication. ..
  26. ROLE OF MELATONIN IN SECONDARY INSOMNIA IN THE ELDERLY
    Nalaka Gooneratne; Fiscal Year: 2004
    ....
  27. DIFFERENTIAL VULNERABILITY TO MORBIDITIES OF SLEEP APNEA
    Sigrid Veasey; Fiscal Year: 2003
    ..Therefore, this work provides an essential foundation for determining gene function in the susceptibility of sleepiness, impaired cognation and behavioral responses caused by obstructive sleep apnea. (End of Abstract.) ..
  28. RATIONAL PHARMACOTHERAPY OF PRIMARY INSOMNIA
    Daniel Buysse; Fiscal Year: 2004
    ..The Principal Investigator will mentor trainees in analyses of existing data, design and implementation of the clinical trial, described above, and new studies designed by the trainees themselves. ..
  29. Melatonin Randomized Trial in Insomnia in the Elderly
    Nalaka Gooneratne; Fiscal Year: 2006
    ..abstract_text> ..
  30. SLEEP AND CHRONOBIOLOGY SUMMER RESEARCH APPRENTICESHIP
    MARY CARSKADON; Fiscal Year: 2005
    ....
  31. Cannabis and Schizophrenia
    Sanjiv Kumra; Fiscal Year: 2010
    ..A positive finding would help inform current neurodevelopmental models of schizophrenia and point to an intervention that might prevent worsening of the illness. ..
  32. Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life
    Sean P A Drummond; Fiscal Year: 2010
    ..This study will examine whether treatments specifically targeted at those sleep disorders can improve clinical outcomes and increase health- related quality of life in individuals recently exposed to war-related trauma. ..
  33. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Longtitudinal Changes in Sleep Structure: Implications for Health Outcomes
    Naresh Punjabi; Fiscal Year: 2010
    ....
  35. Mechanisms of Nicotine Dependence in ADHD Adults
    Scott Kollins; Fiscal Year: 2008
    ..Data generated will also lead to subsequent clinical projects to develop more effective interventions for nicotine dependence in this high risk group. [unreadable] [unreadable] [unreadable]..
  36. Optimization of TMS for Depression
    David Avery; Fiscal Year: 2009
    ..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] ..
  37. MN REGIONAL SLEEP DISORDERS CENTER SLEEP ACADEMIC AWARD
    Gerald Rosen; Fiscal Year: 2002
    ....
  38. Follow up of the PATS sample
    Scott Kollins; Fiscal Year: 2008
    ..Aim 4 is to determine the stability of the ADHD diagnosis and other comorbidities made for study entry at age 3-5 years across subsequent development [unreadable] [unreadable]..
  39. Evaluation of the potential for translation to practice of a sleep disorders mana
    CHARLES CZEISLER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. Contributions of sleep/rhythms/fatigue to "chemobrain"
    Sonia Ancoli Israel; Fiscal Year: 2009
    ..The reported phenomena of chemobrain will be examined to see if it is related to the complaint of fatigue or sleep disruptions, both of which are known to contribute to decreases in cognitive functioning. ..
  41. CIRCADIAN ADAPTATION TO NIGHT WORK IN OLDER PEOPLE
    CHARLES CZEISLER; Fiscal Year: 2001
    ..This work has major implications for the health and safety of older shift workers. ..
  42. Improving Continence & Pain Control in LTC: The M-TRAIN Intervention
    JANET K P SPECHT; Fiscal Year: 2010
    ..The study will evaluate outcomes for nursing homes, elderly residents, and new ways to assist RNs and CNAs use the most current knowledge to care for elders with pain and urinary incontinence. ..
  43. GENETIC DISSECTION OF VENTILATORY TRAITS
    Kingman Strohl; Fiscal Year: 2001
    ..Results will be relevant to illnesses known to result from, or be exacerbated by, poor or excessive ventilatory responses to environmental and pathophysiologic stresses. ..
  44. Preventing Risks of Long Sleep
    SHAWN YOUNGSTEDT; Fiscal Year: 2005
    ..Benefits and risks will be assessed by examining changes in sleepiness, depression, quality-of-life, neurobehavioral performance, glucose tolerance, and actigraphic and subjective sleep. ..
  45. Behavioral Insomnia Therapy With Fibromyalgia
    Jack Edinger; Fiscal Year: 2009
    ..g., pain, fatigue). Results of this trial should provide insights into the pathophysiology and management of FM. ..
  46. CBT and Modafinil for Cocaine Addiction
    Robert Malcolm; Fiscal Year: 2009
    ....
  47. Subcortical Hyperintensities in Sleep Apnea Syndrome
    Mark Aloia; Fiscal Year: 2007
    ..We expect to analyze data on approximately 1,120 participants based on our preliminary studies with this data set. [unreadable] [unreadable]..
  48. FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCER
    Sonia Ancoli Israel; Fiscal Year: 2004
    ..Results will provide a scientific basis for future intervention studies, particularly studies with light therapy which can re-synchronize rhythms. ..
  49. Effects of Extended Work Hours on Intern Health & Safety
    CHARLES CZEISLER; Fiscal Year: 2004
    ....
  50. Aging, Hypnotics, Sleep Inertia and the Risk of Falling
    Kenneth Wright; Fiscal Year: 2005
    ..The results of the proposed research could have a significant impact on the health, safety and quality of life of older adults. ..
  51. Effect of Sleep Deprivation on Inflammatory Markers
    Kenneth Wright; Fiscal Year: 2004
    ..This work could also have a significant impact on our understanding of the health consequences of sleep loss, which would have implications for public health and safety. ..
  52. EPIDEMIOLOGY OF INSOMNIA & MENTAL ILLNESS IN ADOLESCENCE
    Eric Johnson; Fiscal Year: 2004
    ....
  53. AMLODIPINE TREATMENT FOR COCAINE DEPENDENCE
    Robert Malcolm; Fiscal Year: 2001
    ....
  54. WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDY
    Robert Thomas; Fiscal Year: 2006
    ..abstract_text> ..
  55. ACUTE EFFECTS OF LIGHT ON SLEEP
    Ruth Benca; Fiscal Year: 2003
    ..Furthermore, we hope to elucidate the role of the SC-PT in REM sleep regulation, which may have relevance to disorders characterized by abnormalities in REM sleep, and depression ..
  56. THE SLEEP HEART HEALTH STUDY
    Naresh Punjabi; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..
  57. Examining Pathways among Co-occurring Mental and Substance Use Disorders
    Eric Johnson; Fiscal Year: 2007
    ..abstract_text> ..
  58. Genetic Mechanisms for Central Apneas
    Kingman Strohl; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. Phase I Radiosensitization Study of GW572016 in Recurrent Breast Cancer
    ELIZABETH DEES; Fiscal Year: 2007
    ..This proposal pilots a novel combination therapy to treat this common and challenging clinical problem. [unreadable] [unreadable] [unreadable]..
  60. Longitudinal Study--Sleep-Disordered Breathing/Pregnancy
    Grace Pien; Fiscal Year: 2006
    ....
  61. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
    ..Phase II (following 6 months of aripiprazole monotherapy). ..
  62. ECG-derived estimators of sleep physiology
    Robert Thomas; Fiscal Year: 2006
    ..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
  63. PEDIATRIC BIPOLAR COLLABORATIVE MOOD STABILZER TRAIL
    Robert Findling; Fiscal Year: 2003
    ..Lastly, this trial will provide descriptive information on the stability of acute phase response to monotherapy over a 16 week continuation phase. ..
  64. Neuroimaging of Children at Risk for Biopolar Disorder
    Kiki Chang; Fiscal Year: 2006
    ..Chang plans to become an independent investigator in the field of pediatric BD and thus contributing to the current knowledge of the neurobiology and development of BD. ..
  65. Screening for Obstructive Sleep Apnea in Commercial Drivers
    Indira Gurubhagavatula; Fiscal Year: 2009
    ..2) Determine whether an occupational screening evaluation can be combined with home diagnostic technologies to reduce the number of patients that need testing 3) Determine the relative economic costs of these screening strategies ..
  66. Hypoxia-induced apoptosis in a model of sleep apnea
    James McKenna; Fiscal Year: 2004
    ..Overall, it is predicted that the biochemical and apoptotic consequences of IH will be more severe than that of SH, although cellular changes will be observed after both hypoxic exposures. ..
  67. AMYGDALA AND SLEEP
    Ruth Benca; Fiscal Year: 2003
    ..Results obtained from these studies should increase our understanding of the mechanisms underlying sleep abnormalities in psychiatric disorders and insomnia. ..
  68. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  69. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..