sleep disorders


Summary: Conditions characterized by disturbances of usual sleep patterns or behaviors. Sleep disorders may be divided into three major categories: DYSSOMNIAS (i.e. disorders characterized by insomnia or hypersomnia), PARASOMNIAS (abnormal sleep behaviors), and sleep disorders secondary to medical or psychiatric disorders. (From Thorpy, Sleep Disorders Medicine, 1994, p187)

Top Publications

  1. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
  2. ncbi Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Palo Alto, CA 94303, USA
    Sleep 27:1255-73. 2004
  3. pmc Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index
    Shahrad Taheri
    Howard Hughes Medical Institute, Stanford University, Palo Alto, California, USA
    PLoS Med 1:e62. 2004
  4. pmc Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis
    Francesco P Cappuccio
    University of Warwick, Warwick Medical School, Clinical Sciences Research Institute, Coventry, UK
    Diabetes Care 33:414-20. 2010
  5. ncbi Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment
    K Ray Chaudhuri
    National Parkinson Foundation Centre of Excellence, King s College Hospital and University Hospital Lewisham, London, UK
    Lancet Neurol 8:464-74. 2009
  6. pmc Genetics of sleep and sleep disorders
    Amita Sehgal
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 146:194-207. 2011
  7. pmc Sleep and mortality: a population-based 22-year follow-up study
    Christer Hublin
    Research Center, Finnish Institute of Occupational Health, Helsinki, Finland
    Sleep 30:1245-53. 2007
  8. ncbi Inflammatory markers and sleep disturbance in major depression
    Sarosh J Motivala
    Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute, University of California, Los Angeles, CA, USA
    Psychosom Med 67:187-94. 2005
  9. ncbi Sleep schedules and daytime functioning in adolescents
    A R Wolfson
    College of the Holy Cross, Department of Psychology, Worcester, MA 01610, USA
    Child Dev 69:875-87. 1998
  10. ncbi The role and validity of actigraphy in sleep medicine: an update
    Avi Sadeh
    The Adler Center for Research in Child Development and Psychopathology, Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
    Sleep Med Rev 15:259-67. 2011

Detail Information

Publications388 found, 100 shown here

  1. ncbi A new method for measuring daytime sleepiness: the Epworth sleepiness scale
    M W Johns
    Sleep Disorders Unit, Epworth Hospital, Melbourne, Victoria, Australia
    Sleep 14:540-5. 1991
    ..adults answered the ESS, including 30 normal men and women as controls and 150 patients with a range of sleep disorders. They rated the chances that they would doze off or fall asleep when in eight different situations commonly ..
  2. ncbi Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, Palo Alto, CA 94303, USA
    Sleep 27:1255-73. 2004
  3. pmc Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index
    Shahrad Taheri
    Howard Hughes Medical Institute, Stanford University, Palo Alto, California, USA
    PLoS Med 1:e62. 2004
    ..An association between short habitual sleep time and increased body mass index (BMI) has been reported in large population samples. The potential role of metabolic hormones in this association is unknown...
  4. pmc Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis
    Francesco P Cappuccio
    University of Warwick, Warwick Medical School, Clinical Sciences Research Institute, Coventry, UK
    Diabetes Care 33:414-20. 2010
    ..To assess the relationship between habitual sleep disturbances and the incidence of type 2 diabetes and to obtain an estimate of the risk...
  5. ncbi Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment
    K Ray Chaudhuri
    National Parkinson Foundation Centre of Excellence, King s College Hospital and University Hospital Lewisham, London, UK
    Lancet Neurol 8:464-74. 2009
    ..the dopaminergic basis of the range of non-motor symptoms that occur in PD such as depression, apathy, sleep disorders (including rapid-eye movement sleep behaviour disorder), and erectile dysfunction...
  6. pmc Genetics of sleep and sleep disorders
    Amita Sehgal
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 146:194-207. 2011
    ..for deciphering the molecular mechanisms of sleep and attempts to identify genetic underpinnings of human sleep disorders. In this Review, we describe how unbiased, high-throughput screens in model organisms are uncovering sleep ..
  7. pmc Sleep and mortality: a population-based 22-year follow-up study
    Christer Hublin
    Research Center, Finnish Institute of Occupational Health, Helsinki, Finland
    Sleep 30:1245-53. 2007
    ..Long and short sleep have been associated with increased mortality. We assessed mortality and 3 aspects of sleep behavior in a large cohort with 22-year follow-up...
  8. ncbi Inflammatory markers and sleep disturbance in major depression
    Sarosh J Motivala
    Cousins Center for Psychoneuroimmunology, UCLA Neuropsychiatric Institute, University of California, Los Angeles, CA, USA
    Psychosom Med 67:187-94. 2005
    ..This study was conducted to determine whether immune activation occurs in major depression, and to evaluate the associations between disordered sleep and markers of inflammation in patients with major depressive disorder...
  9. ncbi Sleep schedules and daytime functioning in adolescents
    A R Wolfson
    College of the Holy Cross, Department of Psychology, Worcester, MA 01610, USA
    Child Dev 69:875-87. 1998
    ..05, versus those sleeping longer than 8 hr 15 min with less than 60 min weekend delay. Altogether, most of the adolescents surveyed do not get enough sleep, and their sleep loss interferes with daytime functioning...
  10. ncbi The role and validity of actigraphy in sleep medicine: an update
    Avi Sadeh
    The Adler Center for Research in Child Development and Psychopathology, Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
    Sleep Med Rev 15:259-67. 2011 demonstrating that actigraphy is sensitive in detecting unique sleep patterns associated with specific sleep disorders as well as with other medical or neurobehavioral disorders...
  11. ncbi The Children's Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children
    J A Owens
    Division of Pediatric Ambulatory Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence 02903, USA
    Sleep 23:1043-51. 2000
    ..The CSHQ yields both a total score and eight subscale scores, reflecting key sleep domains that encompass the major medical and behavioral sleep disorders in this age group.
  12. ncbi On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders
    Theresa M Buckley
    Stanford Sleep Disorders Clinic and Research Center and Department of Psychiatry, Stanford University, 401 Quarry Road, Suite 3301, Stanford, California 94305, USA
    J Clin Endocrinol Metab 90:3106-14. 2005
    ..Two clinically relevant sleep disorders with likely HPA axis dysfunction, insomnia and obstructive sleep apnea, are discussed...
  13. ncbi Sleep problems and disability retirement: a register-based follow-up study
    Tea Lallukka
    Department of Public Health, University of Helsinki, P O Box 41 Mannerheimintie 172, Helsinki, Finland FIN 00014
    Am J Epidemiol 173:871-81. 2011
    ..In conclusion, sleep problems are associated with subsequent disability retirement. To prevent early exit from work, sleep problems among aging employees need to be addressed...
  14. ncbi Association of physical activity and human sleep disorders
    D L Sherrill
    Respiratory Sciences and Sleep Disorders Center and the Department of Medicine, College of Medicine, University of Arizona, Tucson 85724, USA
    Arch Intern Med 158:1894-8. 1998
    ..with the influence of exercise on sleep architecture and efficiency, and not on its effects in the prevention and treatment of sleep disorders. Moreover, epidemiological evidence of the benefits of exercise on sleep are limited.
  15. pmc Sleep disturbances as a predictor of cause-specific work disability and delayed return to work
    Paula Salo
    Finnish Institute of Occupational Health, Helsinki, Finland
    Sleep 33:1323-31. 2010
    ..To examine sleep disturbances as a predictor of cause-specific work disability and delayed return to work...
  16. pmc Sleep and aging: 1. Sleep disorders commonly found in older people
    Norman Wolkove
    Sleep Clinic, Mount Sinai Hospital Center and the Department of Medicine, McGill University, Montreal, Que
    CMAJ 176:1299-304. 2007
    ..They may also wake more frequently during the night and experience fragmented sleep. The prevalence of many sleep disorders increases with age...
  17. ncbi Sleep disorders in aging and dementia
    S Bombois
    Center for Memory Resources and Research, EA2691, Lille University Hospital, University of Lille Nord de France, Lille Cedex, France
    J Nutr Health Aging 14:212-7. 2010
    This paper reviews the characteristics of sleep disorders found in people at a greater risk of dementia: the elderly adult, patients with mild cognitive impairment (MCI) and those with neurodegenerative diseases...
  18. ncbi The association between short sleep duration and obesity in young adults: a 13-year prospective study
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Sleep 27:661-6. 2004
    ..The objective of this study was to test the hypothesis that short sleep duration is associated with obesity and weight gain during young adulthood...
  19. ncbi Sleep disturbances as a predictor of occupational injuries among public sector workers
    Simo Salminen
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, Helsinki, Finland
    J Sleep Res 19:207-13. 2010
    ..This study suggests that sleep disturbances are a significant predictor of occupational injuries even after accounting for a range of covariates...
  20. pmc Sleep disturbances in Parkinson's disease
    Matthew Menza
    Department of Psychiatry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mov Disord 25:S117-22. 2010
    ..evaluation of sleep disturbances in these patients is complex, as sleep may be affected by a host of primary sleep disorders, other primary medical or psychiatric conditions, reactions to medications, aging or the neuropathophysiology ..
  21. ncbi The impact of media use on sleep patterns and sleep disorders among school-aged children in China
    Shenghui Li
    Shanghai Xin Hua Hospital, Shanghai Children s Medical Center affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Children s Environmental Health, Shanghai, People s Republic of China
    Sleep 30:361-7. 2007
    To determine the amount of television viewing and computer use in urban school-aged Chinese children, and to examine their associations with sleep/wake patterns, duration of sleep, and sleep disorders.
  22. pmc Relationships between the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and clinical/polysomnographic measures in a community sample
    Daniel J Buysse
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Sleep Med 4:563-71. 2008
  23. ncbi Sleep in children with attention-deficit/hyperactivity disorder: meta-analysis of subjective and objective studies
    Samuele Cortese
    Robert Debre Hospital, Paris, France
    J Am Acad Child Adolesc Psychiatry 48:894-908. 2009
    ..To perform a meta-analysis of subjective (i.e., based on questionnaires) and objective (i.e., using polysomnography or actigraphy) studies comparing sleep in children with attention-deficit/hyperactivity disorder (ADHD) versus controls...
  24. ncbi The effects of sleep deprivation on pain inhibition and spontaneous pain in women
    Michael T Smith
    Behavioral Sleep Medicine Program, Johns Hopkins Bayview, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA
    Sleep 30:494-505. 2007
  25. ncbi High incidence of diabetes in men with sleep complaints or short sleep duration: a 12-year follow-up study of a middle-aged population
    Lena Mallon
    Department of Neuroscience, Psychiatry, University Hospital, Uppsala, Sweden
    Diabetes Care 28:2762-7. 2005
    ..The aim of this study was to investigate the possible relationship among sleep complaints, sleep duration, and the development of diabetes prospectively over a 12-year period in a middle-aged Swedish population...
  26. ncbi Sleep disorders in Parkinson's disease
    Michael J Thorpy
    Sleep Wake Disorders Center, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Clin Cornerstone 6:S7-15. 2004
    ..Hypnotic therapy for sleep disturbances in PD patients should be approached with care because of the risks of falling, agitation, drowsiness, and hypotension. Behavioral interventions may also be useful...
  27. ncbi Automatic sleep/wake identification from wrist activity
    R J Cole
    Department of Psychiatry, University of California, San Diego
    Sleep 15:461-9. 1992
    ..0001). Automatic scoring of wrist activity provides valuable information about sleep and wakefulness that could be useful in both clinical and research applications...
  28. ncbi Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep
    Mugdha Gore
    Avalon Health Solutions, Inc, Philadelphia, Pennsylvania 19102, USA
    J Pain Symptom Manage 30:374-85. 2005
    ..01). Painful DPN is associated with decrements in many aspects of patients' lives: physical and emotional functioning, affective symptoms, and sleep problems. The negative impact is higher in patients with greater pain severity...
  29. ncbi Parkinson's disease sleep scale--validation of the revised version PDSS-2
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Kassel, Germany
    Mov Disord 26:644-52. 2011
    ..The previous Parkinson's disease sleep scale (PDSS) is a 15-item visual analogue scale that assesses the profile of nocturnal disturbances in Parkinson's disease (PD) patients...
  30. pmc Case control polysomnographic studies of sleep disorders in Parkinson's disease
    Ming Hui Yong
    Department of Neurology, National Neuroscience Institute, Singapore
    PLoS ONE 6:e22511. 2011
    The relationship between a number of primary sleep disorders and Parkinson's disease (PD) is still debated. There are limited case control polysomnographic studies in PD and most of these study sample sizes are small.
  31. ncbi Sleep duration as a risk factor for the development of type 2 diabetes or impaired glucose tolerance: analyses of the Quebec Family Study
    Jean Philippe Chaput
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    Sleep Med 10:919-24. 2009
    ..To examine the long-term relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT)...
  32. pmc The Parkinson's disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson's disease
    K R Chaudhuri
    Department of Neurology, King s College Hospital, London SE5, UK
    J Neurol Neurosurg Psychiatry 73:629-35. 2002
    ..No formal instruments are available for quantifying sleep problems in Parkinson's disease...
  33. ncbi Sleep disorders in Parkinson disease
    Alex Iranzo de Riquer
    Neurology Service, Hospital Clinic, Barcelona, Spain
    Neurologist 17:S38-42. 2011
    ..The mechanisms by which this occurs and the different types of sleep disorders that a patient with Parkinson disease may suffer (insufficient or fragmented sleep, persistent excessive ..
  34. pmc Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes
    Beth Malow
    Sleep Disorders Division, Department of Neurology and Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Autism Dev Disord 42:1729-37; author reply 1738. 2012
    ..Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population...
  35. ncbi Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders
    Alexandros N Vgontzas
    Department of Psychiatry, Pennsylvania State University, College of Medicine, H073 500 University Dr, Hershey, PA 17033, USA
    Endocrinol Metab Clin North Am 31:15-36. 2002
    Sleep is an important component of mammalian homeostasis, vital for survival. Sleep disorders are common in the general population and are associated with significant medical, psychologic, and social disturbances...
  36. ncbi Never enough sleep: a brief history of sleep recommendations for children
    Lisa Anne Matricciani
    Health and Use of Time Group, University of South Australia, Adelaide SA 5001, Australia
    Pediatrics 129:548-56. 2012
    ..The aim of this study was to describe historical trends in recommended and actual sleep durations for children and adolescents, and to explore the rationale of sleep recommendations...
  37. ncbi The prevalence, cost implications, and management of sleep disorders: an overview
    Jamil L Hossain
    Sleep Research Laboratory, Ontario, Canada
    Sleep Breath 6:85-102. 2002
    The International Classification of Sleep Disorders distinguishes more than 80 different disorders, which can be effectively treated. Problems with falling asleep or daytime sleepiness affect approximately 35 to 40% of the U.S...
  38. ncbi Relationship between sleep disorders and the risk for developing type 2 diabetes mellitus
    Simona Ioja
    Department of Medicine, Norwalk Hospital, Norwalk, CT 06856, USA
    Postgrad Med 124:119-29. 2012
    ..One of the most common sleep disorders, obstructive sleep apnea, is not only highly prevalent in patients with type 2 diabetes mellitus, but may ..
  39. ncbi Annoyance and self-reported sleep disturbance due to night-time railway noise examined in the field
    Sibylle Pennig
    German Aerospace Center DLR, Institute of Aerospace Medicine, 51170 Cologne, Germany
    J Acoust Soc Am 132:3109-17. 2012
    ..The responses of this subject sample referring to railway noise in the previous night point to rather low impairments of exposed residents...
  40. pmc Objective and subjective assessment of sleep in chronic low back pain patients compared with healthy age and gender matched controls: a pilot study
    Grainne M O'Donoghue
    School of Physiotherapy and Performance Science, Health Sciences, University College Dublin, Belfield, Dublin 4, Ireland
    BMC Musculoskelet Disord 10:122. 2009
  41. ncbi Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status
    Michihiro Mieda
    Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, 920 8640, Japan
    CNS Drugs 27:83-90. 2013
    ..have encouraged pharmaceutical companies to develop drugs targeting orexin receptors as novel medications of sleep disorders, such as narcolepsy and insomnia...
  42. pmc Sleep and depression in postpartum women: a population-based study
    Signe Karen Dørheim
    Section for General Practice, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Sleep 32:847-55. 2009
  43. ncbi Sleep disorders in patients with traumatic brain injury: a review
    Richard J Castriotta
    Division of Pulmonary, Critical Care and Sleep Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    CNS Drugs 25:175-85. 2011
    ..This is a major problem for both military- and civilian-related populations. The prevalence of sleep disorders in individuals with TBI is very high, yet mostly unrecognized...
  44. ncbi Sleep disorders in COPD: the forgotten dimension
    Walter T McNicholas
    University College Dublin, Dublin, Ireland
    Eur Respir Rev 22:365-75. 2013
    ..Treatment with continuous positive airway pressure alleviates hypoxaemia, reduces hospitalisation and pulmonary hypertension, and improves survival. ..
  45. ncbi Sleep disorders and fibromyalgia
    Suely Roizenblatt
    Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Avenida Angélica 1996, Andar 1, São Paulo 01228 200, Brazil
    Curr Pain Headache Rep 15:347-57. 2011
    ..Even though sleep recording is not part of the routine evaluation, polysomnography may disclose primary sleep disorders in patients with fibromyalgia, including obstructive sleep apnea and restless leg syndrome...
  46. pmc Short sleep duration and poor sleep quality increase the risk of diabetes in Japanese workers with no family history of diabetes
    Toshiko Kita
    Department of Public Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Diabetes Care 35:313-8. 2012
    ..To investigate whether a difference in the risk for diabetes exists in Japanese workers with regard to sleep duration/quality and the presence or absence of a family history of diabetes (FHD)...
  47. ncbi Pediatric sleep disorders: exploratory modulation of their relationships
    Karen Spruyt
    Department of Psychology, Vrije Universiteit Brussel Free University of Brussels, Belgium
    Sleep 27:495-501. 2004
    ..This study explores relationships between clinically encountered sleep problems in children...
  48. pmc Interaction of sleep quality and psychosocial stress on obesity in African Americans: the Cardiovascular Health Epidemiology Study (CHES)
    Aurelian Bidulescu
    Morehouse School of Medicine, Atlanta, GA, USA
    BMC Public Health 10:581. 2010
    ..Accordingly, we aimed to assess whether sleep quality and duration are inversely associated with body mass index (BMI) and obesity and test whether these associations are modified by psychosocial stress, known to influence sleep quality...
  49. ncbi Parkinson's disease symptoms: the patient's perspective
    Marios Politis
    Department of Clinical Neurosciences, Faculty of Medicine, Hammersmith Hospital, Imperial College, London, United Kingdom
    Mov Disord 25:1646-51. 2010
  50. ncbi Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study
    C Veauthier
    HANSE Klinikum, Department of Neurology, Stralsund, Germany
    Mult Scler 17:613-22. 2011
    b>Sleep disorders can cause tiredness. The relationship between sleep disorders and fatigue in patients with multiple sclerosis (MS) has not yet been investigated systematically.
  51. ncbi Association between workaholism and sleep problems among hospital nurses
    Kazumi Kubota
    Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Ind Health 48:864-71. 2010
    ..However, no significant associations were found between workaholism and insomnia symptoms. These results suggest that workaholic nurses had higher risks for impaired awakening, insufficient sleep, and workplace sleepiness...
  52. pmc Prevalence and consequences of sleep disorders in traumatic brain injury
    Richard J Castriotta
    Division of Pulmonary, Critical Care and Sleep Medicine, University of Texas Health Science Center at Houston, TX 77030, USA
    J Clin Sleep Med 3:349-56. 2007
    Determine prevalence and consequences of sleepiness and sleep disorders after traumatic brain injury (TBI).
  53. doi Suprachiasmatic nucleus and melatonin: reciprocal interactions and clinical correlations
    Eduardo E Benarroch
    Mayo Clinic, Department of Neurology, 200 First Street SW, West 8A Mayo Bldg, Rochester, MN 55905, USA
    Neurology 71:594-8. 2008
  54. ncbi Disturbed sleep and fatigue as predictors of return from long-term sickness absence
    Torbjorn Akerstedt
    Stress Research Institute, Stockholm University, Stockholm, Sweden
    Ind Health 48:209-14. 2010
    ..34-0.90). Intermediate term sickness absence showed similar, but slightly weaker, results. The results indicate that disturbed sleep and fatigue are predictors of lack of return from long term and intermediate term sickness absence...
  55. ncbi Associations between sleep disorders, sleep duration, quality of sleep, and hypertension: results from the National Health and Nutrition Examination Survey, 2005 to 2008
    Pooja Bansil
    Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Clin Hypertens (Greenwich) 13:739-43. 2011
    ..However, to date, no national study has evaluated the simultaneous relationship between sleep disorders, quality, and duration with hypertension...
  56. ncbi Relationship between child sleep disturbances and maternal sleep, mood, and parenting stress: a pilot study
    Lisa J Meltzer
    Division of Pulmonary Medicine, Children s Hospital of Philadelphia, University of Philadelphia, PA 19104, USA
    J Fam Psychol 21:67-73. 2007
  57. ncbi Workplace bullying could play important roles in the relationships between job strain and symptoms of depression and sleep disturbance
    Jiro Takaki
    Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Prefectural University, 2 5 1 Shikata cho, Okayama, Japan
    J Occup Health 52:367-74. 2010
    ..The purpose of this study was to assess whether workplace bullying mediates between job strain, evaluated by the job demand-control model, and symptoms of depression and sleep disturbance...
  58. ncbi Thirty-six-year secular trends in sleep duration and sleep satisfaction, and associations with mental stress and socioeconomic factors--results of the Population Study of Women in Gothenburg, Sweden
    Andisheh Rowshan Ravan
    Department of Primary Health Care, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Sleep Res 19:496-503. 2010
    ..Improvements on society level rather than on the individual level could be expected to be more efficient in improving women's sleep...
  59. pmc Sleep problems and workplace injuries in Canada
    Rakel N Kling
    Centre for Health Services and Policy Research, University of British Columbia, Vancouver British Columbia, Canada
    Sleep 33:611-8. 2010
    ..To investigate the association between sleep problems and risk of work injuries among Canadian workers and to identify working groups most at risk for injuries...
  60. ncbi Impact of subjective sleep quality on glycemic control in type 2 diabetes mellitus
    Yi Wen Tsai
    Department of Family Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan
    Fam Pract 29:30-5. 2012
    ..Glycaemic control is fundamental to the management of and risk reduction in microvascular complications of diabetes...
  61. ncbi Validation of the Brazilian Portuguese version of the Pittsburgh Sleep Quality Index
    Alessandra Naimaier Bertolazi
    Sleep Disorders Center, Pulmonary Service, Hospital de Clínicas de Porto Alegre HCPA, School of Medicine, Universidade Federal do Rio Grande do Sul UFRGS, Brazil
    Sleep Med 12:70-5. 2011
    ..It is a valuable tool for research purposes. The aim of this study was to validate a Brazilian Portuguese version of the PSQI...
  62. ncbi Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson's disease
    Juan Carlos Gómez-Esteban
    Servicio de Neurologia, Hospital de Cruces, Plz de Cruces sn, CP 48903 Baracaldo, Vizcaya, Spain
    J Neurol 258:494-9. 2011
    ..symptoms of Parkinson's disease (PD), such as depression, cognitive deterioration, neuropsychiatric and sleep disorders, affect the quality of life, and to compare them with the motor symptoms in order to determine their real ..
  63. ncbi Sleep disorders, medical conditions, and road accident risk
    Michael H Smolensky
    The University of Texas Houston Health Sciences Center, United States
    Accid Anal Prev 43:533-48. 2011
    b>Sleep disorders and various common acute and chronic medical conditions directly or indirectly affect the quality and quantity of one's sleep or otherwise cause excessive daytime fatigue...
  64. ncbi Sleep characteristics of youth with functional abdominal pain and a healthy comparison group
    Edward D Huntley
    Children s National Medical Center, 111 Michigan Avenue, N W, Washington, DC 20010 2970, USA
    J Pediatr Psychol 32:938-49. 2007
    ..To describe sleep problems among youth with and without functional abdominal pain (FAP)...
  65. ncbi SCOPA-sleep and PDSS: two scales for assessment of sleep disorder in Parkinson's disease
    Pablo Martinez-Martin
    National Centre of Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 23:1681-8. 2008
    ..and the Scales for Outcomes in PD-Sleep Scale (SCOPA-S), two disease-specific rating scales for assessing sleep disorders in Parkinson's disease (PD)...
  66. pmc A twin study of sleep duration and body mass index
    Nathaniel F Watson
    Department of Neurology and University of Washington Medicine Sleep Institute, Seattle, WA 98104 2499, USA
    J Clin Sleep Med 6:11-7. 2010
    ..To determine the relative importance of genetic and environmental contributions to the association between sleep duration and body mass index (BMI)...
  67. pmc Prenatal mood disturbance predicts sleep problems in infancy and toddlerhood
    Thomas G O'Connor
    Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
    Early Hum Dev 83:451-8. 2007
    ..Experimental animal data link prenatal stress with sleep disturbance in offspring, but the link in humans is unclear...
  68. pmc Is homeostatic sleep regulation under low sleep pressure modified by age?
    Mirjam Munch
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Sleep 30:781-92. 2007
    ..Here, we investigated age-related changes in homeostatic sleep regulation under low sleep pressure conditions, with respect to regional EEG differences and their dynamics...
  69. pmc Sleep symptoms predict the development of the metabolic syndrome
    Wendy M Troxel
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Sleep 33:1633-40. 2010
    ..This is the first prospective study to report the association between commonly reported sleep symptoms and the development of the metabolic syndrome, a key CVD risk factor...
  70. ncbi Daylight exposure and the other predictors of burnout among nurses in a University Hospital
    Mustafa Kemal Alimoglu
    Faculty of Medicine, Department of Medical Education, Akdeniz University, Antalya, Turkey
    Int J Nurs Stud 42:549-55. 2005
    ..Suffering from sleep disorders, younger age, job-related health problems and educational level were found to have total or partial direct ..
  71. ncbi Sleep and sleep disorders in older adults
    Kate Crowley
    Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA
    Neuropsychol Rev 21:41-53. 2011
  72. pmc Sleep habits and sleep disturbances in Dutch children: a population-based study
    Raphaële Reine Lydie van Litsenburg
    Department of Pediatrics, VU University Medical Center, 9D11 secretariaat kindergeneeskunde, P O Box 7057, 1007 MB Amsterdam, Netherlands
    Eur J Pediatr 169:1009-15. 2010
    b>Sleep disorders can lead to significant morbidity. Information on sleep in healthy children is necessary to evaluate sleep disorders in clinical practice, but data from different societies cannot be simply generalized...
  73. ncbi Wake and sleep EEG provide biomarkers in depression
    Axel Steiger
    Max Planck Institute of Psychiatry, Department of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    J Psychiatr Res 44:242-52. 2010
    ..Some of these predictive sleep-EEG markers of the longterm course of depression appear to be closely related to hypothalamo-pituitary-adrenocortical system activity...
  74. ncbi Associations of frequent sleep insufficiency with health-related quality of life and health behaviors
    Tara W Strine
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K 66, Atlanta, GA 30341, USA
    Sleep Med 6:23-7. 2005
    ..We examined the association of insufficient sleep with health-related quality of life (HRQOL) and health behaviors...
  75. ncbi Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia
    C F Hatfield
    Department of Anatomy, Cambridge University, Cambridge, UK
    Brain 127:1061-74. 2004
    ..Further characterization of this pathology will facilitate more effective management of sleep patterns in home-dwelling demented patients...
  76. pmc Sleep quality, chronotypes and preferential timing of attacks in migraine without aura
    Sara Gori
    Institute of Neurology, Department of Neurosciences, University of Pisa, Via Roma 67, I 56126, Pisa, Italy
    J Headache Pain 6:258-60. 2005
    ..A preferential timing for occurrence of migraine attacks during the night and early morning hours was documented...
  77. ncbi Non-motor dysfunction in Parkinson's disease
    Tjalf Ziemssen
    Neurological University Clinic, Technische Universitat Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Parkinsonism Relat Disord 13:323-32. 2007
    ..clinical basis of non-motor involvement such as olfactory dysfunction, depression, dementia, dysautonomia and sleep disorders in PD...
  78. ncbi Headache and sleep: examination of sleep patterns and complaints in a large clinical sample of migraineurs
    Leslie Kelman
    The Headache Center of Atlanta, GA 30342, USA
    Headache 45:904-10. 2005
    ..This study characterized sleep parameters and complaints in a large clinical sample of migraineurs and examined sleep complaints in relation to headache frequency and severity...
  79. ncbi Sleep and alertness in children with attention-deficit/hyperactivity disorder: a systematic review of the literature
    Samuele Cortese
    AP HP Hôpital Robert Debré, Service de Psychopathologie de l Enfant et de l Adolescent, Paris, France
    Sleep 29:504-11. 2006
    ..To review evidence on sleep and alertness in children with attention-deficit/hyperactivity disorder (ADHD) controlling for potential confounding factors...
  80. ncbi Symptomatic benign prostate hyperplasia: impact on partners' quality of life
    Dionisios Mitropoulos
    Department of Urology, University of Athens Medical School, 75, Mikras Asias Street, 115 27 Athens, Greece
    Eur Urol 41:240-4; discussion 244-5. 2002
    ..The present study was focused on exploring partner morbidity in cases of symptomatic BPH patients being evaluated for surgical treatment...
  81. pmc Restorative sleep predicts the resolution of chronic widespread pain: results from the EPIFUND study
    K A Davies
    Arthritis Research Campaign Epidemiology Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 47:1809-13. 2008
  82. pmc The effect of short sleep duration on coronary heart disease risk is greatest among those with sleep disturbance: a prospective study from the Whitehall II cohort
    Tarani Chandola
    International Center for Health and Society, Department of Epidemiology and Public Health, University College London Medical School, London, UK
    Sleep 33:739-44. 2010
    ..We investigated whether a combination of short sleep duration and sleep disturbance is associated with a higher risk of CHD than their additive effects...
  83. ncbi Neurocognitive and behavioral morbidity in children with sleep disorders
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Curr Opin Pulm Med 13:505-9. 2007
    ..detail progress made regarding our understanding of the presence and pathophysiology of cognitive and behavioral morbidities among children with sleep disorders in general. Particular focus is given to pediatric obstructive sleep apnea.
  84. ncbi Prevalence of DSM-IV diagnostic criteria of insomnia: distinguishing insomnia related to mental disorders from sleep disorders
    M M Ohayon
    Centre de Recherche Philippe Pinel de Montreal, Quebec, Canada
    J Psychiatr Res 31:333-46. 1997
    ..Conversely, diagnoses were obtained by lay interviews, which may have caused a lack of recognition and/or discrimination for light or borderline symptomatology...
  85. ncbi Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury
    C R Baumann
    Department of Neurology, University Hospital, Zurich, Switzerland
    Neurology 65:147-9. 2005
    ..Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders...
  86. ncbi Sleep in eating disorders
    Christoph J Lauer
    Sleep Disorders Center, Clinic Angermuehle, Angermuehle 8a b, 94469 Deggendorf, Germany
    Sleep Med Rev 8:109-18. 2004
  87. ncbi Sleep in the elderly: normal variations and common sleep disorders
    Sonia Ancoli-Israel
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Harv Rev Psychiatry 16:279-86. 2008
    ..with the medications used to treat those illnesses, or the result of circadian rhythm changes or other sleep disorders. Health care professionals specializing in geriatrics need to learn to recognize the different causes of ..
  88. ncbi Sleep and ADHD
    Eric Konofal
    Pediatric Sleep Disorders Center, Robert Debre Hospital, Paris, France
    Sleep Med 11:652-8. 2010
    ..We also discuss some possible avenues for future research in the field...
  89. pmc Sleep quality predicts quality of life in chronic obstructive pulmonary disease
    Steven M Scharf
    Department of Pulmonary and Critical Care, University of Maryland, Baltimore, MD, USA
    Int J Chron Obstruct Pulmon Dis 6:1-12. 2011
    ..Chronic obstructive pulmonary disease (COPD) patients may suffer from poor sleep and health-related quality of life. We hypothesized that disturbed sleep in COPD is correlated with quality of life...
  90. ncbi The psychological aspects of patients with delayed sleep phase syndrome (DSPS)
    Masako Shirayama
    Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Japan
    Sleep Med 4:427-33. 2003
    ..The current study attempts to define the psychological features of patients with delayed sleep-phase syndrome (DSPS)...
  91. ncbi Progression of Parkinson's disease in the clinical phase: potential markers
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Lancet Neurol 8:1158-71. 2009
    ..In addition to routine clinical rating scales, new quantitative assessments of motor and non-motor symptoms, which should be more broadly available, reasonably priced, and easy-to-use, are needed...
  92. ncbi Non-motor symptoms in Parkinson's disease
    W Poewe
    Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
    Eur J Neurol 15:14-20. 2008
    ..This review article provides an overview of the clinical spectrum of non-motor symptoms in PD together with a brief review of treatment options...
  93. ncbi Sleep in lifetime posttraumatic stress disorder: a community-based polysomnographic study
    Naomi Breslau
    Department of Epidemiology, College of Human Medicine, Michigan State University, East Lansing 48824, USA
    Arch Gen Psychiatry 61:508-16. 2004
    ..Polysomnographic studies conducted on small samples of subjects with specific traumas have yielded conflicting results. We therefore evaluated polysomnographic sleep disturbances in PTSD...
  94. ncbi Practice Parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology
    T A Zesiewicz
    University of South Florida, Tampa, USA
    Neurology 74:924-31. 2010
    ..Articles pertaining to cognitive and mood dysfunction in PD, as well as treatment of sialorrhea with botulinum toxin, were previously reviewed as part of American Academy of Neurology practice parameters and were not included here...
  95. ncbi Headache and sleep
    Andrea Alberti
    Sleep Laboratory, Neurologic Clinic of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Sleep Med Rev 10:431-7. 2006
    ..CH) and hypnic headache (HH) can be triggered by sleep, while chronic morning headaches can be caused by sleep disorders such as sleep apnoea and insomnia...
  96. ncbi The relationship of glucose tolerance to sleep disorders and daytime sleepiness
    Anna Kaisa Renko
    Department of Public Health Science and General Practice, University of Oulu, PO Box 5000, University of Oulu, Oulu 90014, Finland
    Diabetes Res Clin Pract 67:84-91. 2005
    ..All sleep disorders associated with neck circumference, waist circumference and body mass index (BMI)...
  97. ncbi Genetic aspects of normal and disturbed sleep
    Mehdi Tafti
    Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne, Switzerland
    Sleep Med 10:S17-21. 2009
    b>Sleep disorders commonly involve genetic susceptibility, environmental effects, and interactions between these factors...
  98. ncbi Parkinson's disease and sleepiness: an integral part of PD
    I Arnulf
    Fédération des pathologies du sommeil, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    Neurology 58:1019-24. 2002
    ..To investigate the potential causes of excessive daytime sleepiness in patients with PD-poor sleep quality, abnormal sleep-wakefulness control, and treatment with dopaminergic agents...
  99. ncbi Scales to assess sleep impairment in Parkinson's disease: critique and recommendations
    Birgit Hogl
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 25:2704-16. 2010
    ..The task force does not recommend the development of new scales, but emphasizes the need for educational efforts to train physicians in sleep interview techniques and polysomnography...
  100. ncbi Long-term effects of widowhood after terminal cancer: a Swedish nationwide follow-up
    Unnur Valdimarsdottir
    Department of Clinical Cancer Epidemiology, Institute of Oncology Pathology, Karolinska Institute, Box 4402, 10268 Stockholm, Sweden
    Scand J Public Health 31:31-6. 2003
    ..The authors investigated whether becoming a widow after the death of a husband from cancer results in long-term psychological or physical morbidity...
  101. pmc Correlates of short and long sleep duration: a cross-cultural comparison between the United Kingdom and the United States: the Whitehall II Study and the Western New York Health Study
    Saverio Stranges
    Cardiovascular Medicine and Epidemiology Group, Clinical Sciences Research Institute, University of Warwick Medical School, University Hospital Warwickshire and Coventry Campus, Clifford Bridge Road, Coventry, United Kingdom
    Am J Epidemiol 168:1353-64. 2008
    ..97 (95% CI: 0.95, 0.99)). Being unmarried, being overweight, and having poor general health are associated with short sleep and may contribute to observed disease associations. Long sleep may represent an epiphenomenon of comorbidity...

Research Grants82

  1. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..have a higher than normal incidence of impaired cardiac function, autonomic nervous system disorders, sleep disorders, delayed speech and central and obstructive apneas...
  2. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..regulates natural sleep holds the promise of providing a basis for the rational development of treatments for sleep disorders affecting the veteran population, such as sleep apnea, narcolepsy, insomnia, and sleep disturbance related to ..
  3. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..of attention deficit hyperactivity disorder, depression, Parkinson's and Alzheimer's diseases, and sleep disorders. Our studies focus on the key periods of development of LCNN from the completion of neurogenesis in the fetus ..
  4. Cerebral metabolism, EEG, and sleep cycling in critically ill neonates
    Renée A Shellhaas; Fiscal Year: 2013
    ..The University of Michigan Medical School, Department of Pediatrics, and Sleep Disorders Center provide an exceptional environment for career development...
  5. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..fact that approximately 80% of PD patients suffer from co-morbid neuropsychiatric conditions like depression, sleep disorders, anxiety and dementia. Many of these conditions have been linked to dysfunctional 5HT neurochemistry...
    Sridhar Sunderam; Fiscal Year: 2013
    ..providing information about sleep-wake state and sleep architecture, which are important for investigating sleep disorders. The current gold standard for sleep analysis in mammals is electroencephalography (EEG) with ..
  7. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    ..Co-mentor Michael Dickel, Ph.D., Staff of Sleep Disorders Laboratory in VA Long Beach Medical Center, is a board-certified sleep medicine specialist with extensive ..
  8. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..The 1,4-benzodiazepines, employed to treat anxiety disorders as well as sleep disorders exhibit anxiolytic, anticonvulsant, muscle relaxant/ataxic, sedative- hypnotic and amnestic effects...
  9. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..associated with low levels or a lack of estrogens, including decreased sexual motivation, hot flushes, sleep disorders, depression/anxiety, brain and spinal cord trauma, amyotrophic lateral sclerosis, and cognitive dysfunction...
  10. RidCancerPain Intervention in a Hispanic Population Along the US-Mexico Border
    KRISTYNIA MARIE contact ROBINSON; Fiscal Year: 2010
    ..the likelihood of minorities suffering from the costly consequences of uncontrolled pain such as depression, sleep disorders, lost work productivity, and impaired relationships with family and friends (American Pain Foundation, 2009;..
  11. Predictors of sleep-dependent Memory Consolidation in Obstructive Sleep Apnea
    Ina E Djonlagic; Fiscal Year: 2013
    ..Atul Malhotra, Associate Professor of Medicine at Harvard Medical School and Medical Director of the Sleep Disorders Research Program at Brigham and Women's Hospital as well as Dr...
  12. Discovery of Selective MT1 Melatonin Receptor Ligands for Sleep Disorders
    Margarita L Dubocovich; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sleep disorders due to stress, illness, chronic pain, and poor sleep habits are a major social and health concern, resulting in lost work, decreased attention and productivity, daytime drowsiness, ..
  13. Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2013
    ..The zebrafish will help us understand how MCH can regulate food consumption, energy balance, and sleep, and thus how MCH could be manipulated to prevent feeding or sleep disorders in the general public.
  14. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..eating habits, and hormonal levels, as well potentially involved in a variety of disorders including sleep disorders, seasonal affected disorders and glaucoma, the NIH has highlighted melanopsin as a priority for future ..
  15. Mechanisms and consequences of sleep disordered breathing in COPD
    Cynthia D Brown; Fiscal Year: 2012
    ..Her specific area of interest is in sleep disorders in chronic lung disease, and the period of time covered by the career development award is important for Dr...
  16. Basal Forebrain Cellular Mechanisms of Cortical Activation
    Robert W McCarley; Fiscal Year: 2013
    ..Furthermore, gamma deficits are a prominent feature of sleep disorders, coma, and Alzheimer's disease, other conditions prevalent in veterans and military personnel...
  17. Novel CNS Target for Sleep-Wake and Psychiatric Disorders
    SCOTT MCNEAR THACHER; Fiscal Year: 2010
    ..and consolidating signals from the SCN, will have widespread therapeutic potential in circadian rhythm sleep disorders (CRSDs) such as delayed sleep phase disorder (DSPD), jet lag, shift work sleep disorder, and dementia, where ..
  18. Integration of sleep/wake network models across multiple temporal and spatial sca
    ANDREW JOHN PHILLIPS; Fiscal Year: 2013
    ..This sleep/wake switch theory has become the basis for understanding some sleep disorders (e.g., narcolepsy) and the effects of aging on sleep...
  19. Improving Quality of Care in Parkinsons Disease: A Randomized Controlled Trial
    KAREN ILENE CONNOR; Fiscal Year: 2013
    ..more symptoms over time, affects motor abilities, and has a wide range of non-motor dysfunctions including sleep disorders, depression, and cognitive impairment that broadly impact physical, mental, and social dimensions of health-..
  20. Preoptic histamine signaling in thermoregulation and energy expenditure
    IUSTIN VIRGIL TABAREAN; Fiscal Year: 2012
    ..These studies will therefore have implications for understanding metabolic disorders, such as obesity and diabetes, as well as sleep disorders such as excessive day sleepiness and narcolepsy.
  21. Adult Neurogenesis: Regulation By Sleep
    DENNIS J MCGINTY; Fiscal Year: 2013
    ..There is no specific neurological rationale for coincident management of sleep disorders and MDD or other disorders...
  22. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2013
    ..Furthermore, people with genetic sleep disorders involving the circadian clock are also more vulnerable to alcoholism and addiction...
  23. Cellular Mechanisms for the hormonal Modulation of Sleep
    Jessica Mong; Fiscal Year: 2009
    ..In fact, the 2003 revision of the National Sleep Disorders Research Plan indicated that "enhanced efforts are needed to better understand the neurophysiology of sleep ..
  24. Functional Anatomy of REM Sleep: Brainstem-Control
    Gerald A Marks; Fiscal Year: 2013 the understanding of the mechanisms of REM sleep, which can have a direct impact on several serious sleep disorders such as narcolepsy, REM sleep behavior disorders and REM-related parasomnias...
    William A Catterall; Fiscal Year: 2013
    ..including susceptibility to thermally induced seizures and spontaneous seizures, ataxia, circadian rhythm and sleep disorders, cognitive deficit, autistic-like features, and premature death...
  26. Sleep and Cardiovascular Health
    Phyllis C Zee; Fiscal Year: 2012
    ..Further, evidence suggests that poor health status also increases the prevalence of sleep disorders. This relationship may be particularly prominent in older adults, who often have the burden of both sleep ..
    Thomas S Kilduff; Fiscal Year: 2010
    ..not only enhance our understanding of sleep/wake regulation, but may also have implications for understanding sleep disorders and neurological and psychiatric diseases involving the cerebral cortex such as epilepsy, anxiety, and ..
  28. Identification and Validation of Human Hypothalamic Nuclei in-vivo and ex-vivo Us
    Nikolaos Makris; Fiscal Year: 2010
    ..understanding women's health and sex differences in relation to neurological, psychiatric, endocrine and sleep disorders. In fact, hypothalamic nuclei, key regulators of autonomic and endocrine functions, are some of the most ..
  29. Cytokine and neurotransmitter interactions in sleep regulation
    Mark R Opp; Fiscal Year: 2012
    ..In addition to effects on cognition and performance, lack of sleep, or sleep disruption due to sleep disorders may be a contributing factor to multiple pathologies, including but not limited to hypertension, coronary ..
  30. Insomnia and Sleep Disordered Breathing in Seniors: A Longitudinal Outcome Study
    Nalaka S Gooneratne; Fiscal Year: 2010
    ..However, polysomnography is necessary for the diagnosis of other common sleep disorders, such as sleep-related breathing disorder...
  31. Hypocretin and its receptors Gene Transfer for Narcolepsy
    Meng Liu; Fiscal Year: 2013
    ..Priyattam Shiromani's laboratory in 2006 to start a new research field: gene therapy for sleep disorders. We published the first "proof of principal" paper in narcolepsy gene transfer research area in 2008...
  32. Molecular mechanisms of potassium channel permeation and gating
    Crina M Nimigean; Fiscal Year: 2013
    ..channels are targets for a large number of drugs which help control conditions such as pain, hypertension, sleep disorders, psychiatric disorders...
  33. Long-term effects of caffeine therapy for apnea of prematurity on sleep disorders
    Carole L Marcus; Fiscal Year: 2012
    ..adverse effects on sleep architecture and ventilatory control, resulting in an increased prevalence of sleep disorders such as insomnia and the obstructive sleep apnea syndrome (OSAS)...
  34. Translating CBT-Insomnia for Lung Cancer into practice: A RCT
    Grace E Dean; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lung cancer survivors have a particularly high risk of developing sleep disorders relative to other cancer survivors...
  35. The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients
    AMY WILLIS AMARA; Fiscal Year: 2013
    ..b>Sleep disorders are common, affecting 74-98% of PD patients (1, 5)...
    EVA LUCILLE FELDMAN; Fiscal Year: 2013
    ..We offer clinical science training in neurodegenerative disorders, neuromuscular diseases, sleep disorders, stroke, and systems neuroscience...
  37. Neuropeptidomics of Clock-to-Clock Coupling
    Martha U Gillette; Fiscal Year: 2010
    ..and circadian clocks in other cells and tissues has been implicated in systems pathologies that lead to sleep disorders. The goal of this discovery proposal is to identify peptides that couple the SCN and [glial] circadian clocks...
  38. Sleep promotion in zebrafish by hypocretin neuronal networks
    Philippe Mourrain; Fiscal Year: 2012
    ..15% of the population suffers of sleep disorders. However, sleep is still a poorly understood phenomenon...
  39. Amygdala CRH, Insomnia and Depression
    Rong Zhang; Fiscal Year: 2012
    ..environmental risk factors utilizing corticotropin-releasing hormone that underlying the onset of mood and sleep disorders. Elucidation of these mechanisms, and the role of genetic vulnerability that alter mediating pathways, is ..
  40. Sleep and Circadian Rhythms in Tuberous Sclerosis Complex
    JONATHAN OREN LIPTON; Fiscal Year: 2013
    ..Treatment of sleep disorders in TSC and other neurodevelopmental syndromes has been limited by a fundamental lack of understanding of the ..
  41. The Role Leptin on Arousal
    PAIGE B BECK; Fiscal Year: 2013
    ..important because, by determining the role of leptin in the PPN and, therefore, sleep and waking, the potential role of leptin in sleep disorders and perhaps a number of psychiatric and neurological disorders will also be determined.
  42. The Overlap Syndrome of COPD and OSA: Determinants of Health Status and Outcomes
    Theodore A Omachi; Fiscal Year: 2012
    ..Samuel Kuna, who researches the ambulatory management of OSA;Dr. David Claman, Director of the UCSF Sleep Disorders Center;Dr. Patricia Katz, an expert in psychometric analyses;and Dr...
  43. Reversibility of Cardiovascular Injury with CPAP Use: Mechanisms Involved
    Claudia E Korcarz; Fiscal Year: 2013 independent investigator that designs and conducts rigorous patient- oriented research projects related to sleep disorders and CVD. Dr...
  44. Optogenetic Control of Vigilance State Transition
    Luis de Lecea; Fiscal Year: 2013
    ..These experiments may also lead to new and enhanced treatments for narcolepsy, insomnia and other sleep disorders. PUBLIC HEALTH RELEVANCE: Our data will expand the use of state-of-the-art optogenetic methods in sleep ..
  45. Cycling of Circadian Rhythm Proteins
    Amita Sehgal; Fiscal Year: 2013
    ..Disrupted functioning of clocks has been associated with sleep disorders as well as other pathologies such as tumor growth...
  46. CRCNS: Multiresolution Modeling of Human Thalamocortical Upstates and Downstates
    Eric Halgren; Fiscal Year: 2013
    ..states, further research based on the models could be applied to abnormal EEG/MEG from patients with sleep disorders, to predict the mechanisms that may be responsible for the observed abnormalities...
  47. GABAA Receptor-Interacting Proteins
    Angel L De Blas; Fiscal Year: 2013 neurological and mental disorders including epilepsy, anxiety, depression, schizophrenia, autism and sleep disorders, among others...
  48. Electric Studies of Excitation, Secretion &Contraction
    Bertil Hille; Fiscal Year: 2013
    ..Understanding the rhythmic secretory mechanisms of the pineal will make an important contribution towards treating sleep disorders, seasonal affective responses to short days, and loss of attention due to jet lag and shift work.
  49. Epidemiologic Research and Surveillance in Epilepsy (U01) Component A
    Barbara L Kroner; Fiscal Year: 2013
    ..personal history of epilepsy, types of care sought and received, comorbidities such as cardiac disease and sleep disorders, family history of epilepsy, and the family and social environment...
  50. Physiology of intrinsically photosensitive retinal ganglion cells
    Kwoon Y Wong; Fiscal Year: 2013
    ..responses, such as occurs in shift workers or the blind, can lead to "jet lag" symptoms, winter depression, sleep disorders, headache, and even breast and prostate cancer...
  51. The role of RNA binding proteins in the control of Drosophila circadian rhythms
    Patrick Emery; Fiscal Year: 2013
    ..and somatic ailments in humans, particularly in shift worker and in patients with specific mood and sleep disorders. Our work should thus ultimately help understanding of the biological bases of these diseases...
  52. Translational Neurotech Summit
    CASEY LYNCH; Fiscal Year: 2010
    ..obesity, pain, Parkinson's disease, sensory disorders, spinal cord injury, stroke, schizophrenia, sleep disorders, and traumatic brain injury...
  53. Purinergic Mechanisms in Homeostatic Sleep Control
    Radhika Basheer; Fiscal Year: 2013
    ..sleepiness and associated neurobehavioral deficits experienced by military personnel and for the treatment of sleep disorders in veterans...
  54. Home sleep and circadian phase: mediators of racial disparities in diabetes risk
    Kristen Knutson; Fiscal Year: 2013
    ..We plan to study 72 African Americans and 72 non-Hispanic whites without diabetes or sleep disorders. We have preliminary data that 1) support the existence of racial differences in the duration, structure and ..
  55. Adenosine, Hypocretin and Sleep Disorder Comorbidities Associated with Epilepsy
    Kristina A Simeone; Fiscal Year: 2013
    ..At least one third of epilepsy patients are afflicted with sleep disorder comorbidities, however, because sleep disorders are often overlooked, a realistic estimate may be much higher...
  56. Positive Airway Pressure Gas Modulator - A Novel Method to Treat Central Sleep Ap
    HANI AKRAM KAYYALI; Fiscal Year: 2011
    ..Our goal is in strong agreement with NIH's recommendation for future sleep disorders research as clearly indicated in the most recent National Center for Sleep Disorders Research Plan...
    Anne B Newman; Fiscal Year: 2013
    ..and prevention clinical trials in osteoporosis, sarcopenia, cardiovascular aging, longevity cancer and aging, sleep disorders, cognitive decline and disability prevention...
  58. Self Organized Criticality as a new paradigm of sleep regulation
    PLAMEN CHRISTOV IVANOV; Fiscal Year: 2013
    ..of arousals and sleep-stage transitions;(iii) to derive novel and more sensitive diagnostic markers of sleep disorders. We will analyze a large database from (i) healthy human subjects, and (ii) subjects with insomnia, ..
  59. The role of ubiquitination in regulating GABA(A) receptor functional expression
    Stephen J Moss; Fiscal Year: 2010
    ..compromised GABAA receptor function is central to a number of CMS pathologies including epilepsy, anxiety, sleep disorders, addiction, autism, mental retardation, depression and schizophrenia...
  60. Circadian Misalignment and Energy Metabolism
    Kenneth P Wright; Fiscal Year: 2013
    ..g., health care, emergency response, security personnel) and in circadian sleep disorders including, but not limited to, shift work and jet lag disorder...
  61. Sleep in Cardiac patients with Implantable Cardioverter Defibrillators (ICD)
    CHRISTINA MCCRAE; Fiscal Year: 2009
    ..Such information is important, because different sleep disorders require very different treatment approaches...
  62. Determining the Mechanism of Temperature Compensation of the Circadian Clock
    Deborah Bell-Pedersen; Fiscal Year: 2013
    ..In humans, abnormalities in the oscillator are associated with sleep disorders, cardiovascular disease, metabolic syndrome, and cancer...
  63. Role of OFQ/N in Regulating the Prolactin Response to Stress
    Phyllis Callahan; Fiscal Year: 2007
    ..numerous pathologies, including disorders in the cardiovascular, immune and reproductive systems, as well as sleep disorders, depression and substance abuse...
  64. Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life
    Sean P A Drummond; Fiscal Year: 2010
    ..Recognition of the negative impact of poor sleep and sleep disorders across patient populations has grown to the point where NIH convened a special conference in April 2009 ..
  65. Psychoactive Medications: Associations with Delirium Persistance vs Resolution
    Edward Marcantonio; Fiscal Year: 2009 this population, either for the management of delirium itself, or for comorbid conditions, such as sleep disorders and pain...
    Kingman Strohl; Fiscal Year: 2002
    The goals of this SLEEP ACADEMIC AWARD are to implement and assess a knowledge system for sleep and sleep disorders. The proposal links educational specialists, training programs, and sleep research at Case Western Reserve University ..
  67. Photoreceptors Involved in Chlamydomonas reinhardtii Circadian Entrainment
    SIGRID JACOBSHAGEN; Fiscal Year: 2007
    ..clock in humans is important for understanding health problems related to a defective clock like certain sleep disorders and depressions...
    ROBERT MC CARLEY; Fiscal Year: 2005
    ..modulates behavioral state and thereby to provide a sound basis for the understanding and treatment of human sleep disorders, especially narcolepsy...
  69. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    ..One approach to improving seizure control is to treat coexisting sleep disorders, such as obstructive sleep apnea...
  70. Development of Automated Noninvasive DiskTreadmills for Sleep Deprivation in Mice
    Jidong Fang; Fiscal Year: 2007
    ..novel noninvasive automatic sleep restriction system for mice, an increasingly important species for studying sleep disorders. PSU has recently developed a disc-treadmill method to perform sleep deprivation in mice based on ..
    Mahesh Thakkar; Fiscal Year: 2004
    ..the REM and nonREM phases, and thereby provide a sound basis for the understanding and treatment of human sleep disorders, both primary and secondary to medical and psychiatric conditions...
  72. Sleep Disorders Management, Health and Safety in Police
    CHARLES CZEISLER; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Sleep Disorders may cause the deaths of up to 20,000 people each year in the United States, and lead to loss of health, poor quality of life, and decreased job productivity...
  73. Orexins in Rapid Eye Movement Sleep Control.
    Mahesh Thakkar; Fiscal Year: 2009
    ..There is considerable evidence linking orexins to cataplexy/narcolepsy, which may be regarded as REM sleep disorders. While the cell bodies of orexin neurons are exclusively localized in the lateral hypothalamus, orexin ..
  74. Blue-White Light Therapy for Circadian Sleep Disorders in Alzheimer's Disease
    Philip Sloane; Fiscal Year: 2009
    ..and safety of several million elderly who have dementia and clinically significant circadian-related sleep disorders, and also benefit their caregivers. PUBLIC HEALTH RELEVANCE: Approximately five million persons in the U.S.A...
    Michael Chase; Fiscal Year: 2004
    Abnormal patterns of motor behavior are a key component of a number of sleep disorders. These patterns of behavior are evidenced, for example, during wakefulness by cataplectic attacks, in which the motor inhibition that normally occurs ..
    Terry Young; Fiscal Year: 2006
    ..state in nearly every woman during her lifetime, even a small effect on sleep apnea and insomnia, the major sleep disorders, would translate into significant morbidity...
  77. Promoting Sleep Health in Pediatric Primary Care Settings: A Web-based CME Course
    Lisa Marceau; Fiscal Year: 2009
    ..that poor sleep is an unmet public health problem and that, "cumulative long- term effects of sleep loss and sleep disorders have been associated with a wide range of deleterious health consequences.....
  78. Sleep disorders and QOL in lung cancer survivors
    Nalaka Gooneratne; Fiscal Year: 2009
    ..b>Sleep disorders, such as insomnia, are especially common...
  79. Disadvantaged Children: Predictors and Outcomes of Sleep Behaviors
    Lauren Hale; Fiscal Year: 2010
    ..The 2003 National Sleep Disorders Research Plan acknowledges that: (a) low socioeconomic status is associated with diminished opportunity for ..
  80. 18F-Mefway for Imaging Mood Disorders and Alzheimer's Disease
    JOGESH MUKHERJEE; Fiscal Year: 2009
    ..Serotonin 5HT1A receptors have been investigated in a number of CNS disorders, including depression, anxiety, sleep disorders, epilepsy, Parkinson's disease (PD) and Alzheimer's disease (AD)...
  81. Outcomes of Sleep Disorders in Older Men- Reading Center
    Susan Redline; Fiscal Year: 2007
    The proposed study, Outcomes of Sleep Disorders in Older Men, will take advantage of the established cohort that has been recruited for the Osteoporotic Fractures in Men (MrOS) study (5U01AR045647 - Dr...
  82. New Faculty Recruitment to Enhance Sleep Disorders Research Program
    Jesse B Hall; Fiscal Year: 2010
    ..enhance research efforts at the University of Chicago that aim to advance the understanding and treatment of sleep disorders by obtaining support for the hiring of a new tenure-track faculty at the Assistant Professor level...