nervous system alcohol induced disorders

Summary

Summary: Acute and chronic neurologic disorders associated with the various neurologic effects of ETHANOL. Primary sites of injury include the brain and peripheral nerves.

Top Publications

  1. ncbi Neurogenesis in adolescent brain is potently inhibited by ethanol
    F T Crews
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, 27599 7178, USA
    Neuroscience 137:437-45. 2006
  2. ncbi In vivo quantification of ethanol kinetics in rat brain
    Elfar Adalsteinsson
    Harvard MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
    Neuropsychopharmacology 31:2683-91. 2006
  3. ncbi Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder
    Rafael Galindo
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 871310001, USA
    J Neurochem 94:1500-11. 2005
  4. ncbi Neuroapoptosis in the infant mouse brain triggered by a transient small increase in blood alcohol concentration
    Chainllie Young
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Neurobiol Dis 22:548-54. 2006
  5. ncbi Cannabinoids enhance susceptibility of immature brain to ethanol neurotoxicity
    Henrik H Hansen
    Department of Pediatric Neurology and Neuroscience Research Center, Humboldt University, Berlin, Germany
    Ann Neurol 64:42-52. 2008
  6. ncbi DBH*444G/A polymorphism of the dopamine-beta-hydroxylase gene is associated with alcoholism but not with severe alcohol withdrawal symptoms
    M D Köhnke
    University Hospital of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany
    J Neural Transm 113:869-76. 2006
  7. ncbi Ethanol induces glutamate secretion by Ca2+ mobilization and ROS generation in rat hippocampal astrocytes
    Miguel Salazar
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Avenida Universidad s n, E 10071, Caceres, Spain
    Neurochem Int 52:1061-7. 2008
  8. ncbi Ethanol-induced changes in proenkephalin mRNA expression in the rat nigrostriatal pathway
    MILAGROS MENDEZ
    Departamento de Neuroquimica, Calzada Mexico Xochimilco 101, Col San Lorenzo Huipulco, 14370, Mexico D F, Mexico
    J Mol Neurosci 34:225-34. 2008
  9. ncbi Changed accumbal responsiveness to alcohol in rats pre-treated with nicotine or the cannabinoid receptor agonist WIN 55,212-2
    Jose Antonio Lopez-Moreno
    Laboratory of Psychobiology, Faculty of Psychology, Campus de Somosaguas, Complutense University of Madrid, 28223, Madrid, Spain
    Neurosci Lett 433:1-5. 2008
  10. ncbi Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission
    Nayana Wijayawardhane
    Department of Pharmacal Sciences, 401 Walker Building, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
    Neurobiol Dis 26:696-706. 2007

Research Grants

  1. DEVELOPMENTAL BRAIN DAMAGE BY DRUGS OF ABUSE
    John W Olney; Fiscal Year: 2010
  2. ACUTE BRAIN INJURY, MECHANISMS AND PROTECTION
    John Olney; Fiscal Year: 2001
  3. NEUROPROTECTION AGAINST RETINAL ISCHEMIA
    John Olney; Fiscal Year: 2001
  4. Transdermal Cannabidiol Delivery for Alcohol-Induced Neurodegeneration
    Kimberly Nixon; Fiscal Year: 2007
  5. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2004
  6. Brain Tissue Resource Centre for Alcohol Research
    Clive Harper; Fiscal Year: 2007
  7. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006
  8. IL-6 Regulation of Hippocampal Synaptic Function
    Donna L Gruol; Fiscal Year: 2010
  9. Neurobehavioral Consequences of Adolescent Alcohol
    Cindy Ehlers; Fiscal Year: 2008
  10. Cannabinoid Receptor Function in Alcoholism: Effects of D-9-THC
    DEEPAK D SOUZA; Fiscal Year: 2008

Detail Information

Publications160 found, 100 shown here

  1. ncbi Neurogenesis in adolescent brain is potently inhibited by ethanol
    F T Crews
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, 27599 7178, USA
    Neuroscience 137:437-45. 2006
    ..These studies indicate that the adolescent brain is very sensitive to acute ethanol inhibition of neurogenesis...
  2. ncbi In vivo quantification of ethanol kinetics in rat brain
    Elfar Adalsteinsson
    Harvard MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
    Neuropsychopharmacology 31:2683-91. 2006
    ..Serial proton spectroscopy measurements provide a valid in vivo method for quantifying brain alcohol uptake and elimination kinetics in real time...
  3. ncbi Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder
    Rafael Galindo
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 871310001, USA
    J Neurochem 94:1500-11. 2005
    ....
  4. ncbi Neuroapoptosis in the infant mouse brain triggered by a transient small increase in blood alcohol concentration
    Chainllie Young
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Neurobiol Dis 22:548-54. 2006
    ..Since blood ethanol elevations in this range are commonly achieved by humans in a social drinking context, a mother with only a moderate drinking habit might expose her fetus to such elevations on multiple occasions during pregnancy...
  5. ncbi Cannabinoids enhance susceptibility of immature brain to ethanol neurotoxicity
    Henrik H Hansen
    Department of Pediatric Neurology and Neuroscience Research Center, Humboldt University, Berlin, Germany
    Ann Neurol 64:42-52. 2008
    ..Neurocognitive deficits have been reported in children whose mothers used marijuana during pregnancy. Maternal consumption of ethanol is known to cause serious developmental deficits..
  6. ncbi DBH*444G/A polymorphism of the dopamine-beta-hydroxylase gene is associated with alcoholism but not with severe alcohol withdrawal symptoms
    M D Köhnke
    University Hospital of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany
    J Neural Transm 113:869-76. 2006
    ..Frequencies of alleles and genotypes of individuals with mild withdrawal symptoms did not differ significantly from those of patients with DT or AWS...
  7. ncbi Ethanol induces glutamate secretion by Ca2+ mobilization and ROS generation in rat hippocampal astrocytes
    Miguel Salazar
    Department of Physiology Cell Physiology Research Group, University of Extremadura, Avenida Universidad s n, E 10071, Caceres, Spain
    Neurochem Int 52:1061-7. 2008
    ....
  8. ncbi Ethanol-induced changes in proenkephalin mRNA expression in the rat nigrostriatal pathway
    MILAGROS MENDEZ
    Departamento de Neuroquimica, Calzada Mexico Xochimilco 101, Col San Lorenzo Huipulco, 14370, Mexico D F, Mexico
    J Mol Neurosci 34:225-34. 2008
    ..Alterations in enkephalin expression in the substantia nigra and CP in response to ethanol exposure could be involved in the mechanisms underlying brain sensitivity to the drug...
  9. ncbi Changed accumbal responsiveness to alcohol in rats pre-treated with nicotine or the cannabinoid receptor agonist WIN 55,212-2
    Jose Antonio Lopez-Moreno
    Laboratory of Psychobiology, Faculty of Psychology, Campus de Somosaguas, Complutense University of Madrid, 28223, Madrid, Spain
    Neurosci Lett 433:1-5. 2008
    ..Therefore, cannabinoid and nicotine exposure may have important implications on the rewarding effects of alcohol, because these drugs lead to long-lasting changes in accumbal dopamine transmission...
  10. ncbi Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission
    Nayana Wijayawardhane
    Department of Pharmacal Sciences, 401 Walker Building, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
    Neurobiol Dis 26:696-706. 2007
    ..These results highlight the possibility that aniracetam treatment can restore synaptic transmission and ameliorate cognitive deficits associated with the fetal alcohol syndrome...
  11. ncbi Effects of alcohol exposure during early life on neuron numbers in the rat hippocampus. I. Hilus neurons and granule cells
    Takanori Miki
    Department of Anatomy, Faculty of Medicine, Kagawa Medical University, Kagawa, Japan
    Hippocampus 13:388-98. 2003
    ..The effects on hilar neuron numbers, observed as a result of such short periods of ethanol treatment, appeared to be transitory...
  12. pmc Ethanol dually modulates GABAergic synaptic transmission onto dopaminergic neurons in ventral tegmental area: role of mu-opioid receptors
    C Xiao
    Department of Anesthesiology, Physiology and Pharmacology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Neuroscience 153:240-8. 2008
    ..This dual modulation of GABAergic transmission by ethanol may be an important mechanism underlying alcohol addiction...
  13. ncbi Differential protein expression profiles in the hippocampus of human alcoholics
    H Matsuda-Matsumoto
    Discipline of Pathology, Faculty of Medicine, The University of Sydney, NSW 2006, Australia
    Neurochem Int 51:370-6. 2007
    ..Based upon the results, several hypotheses were generated to explain the mechanisms underlying possible functional and/or structural alterations induced by chronic alcohol use in this brain region...
  14. ncbi Anticonvulsive effects of kappa-opioid receptor modulation in an animal model of ethanol withdrawal
    A S Beadles-Bohling
    Department of Behavioral Neuroscience, Oregon Health and Science University Research Service, Portland, OR 97239, USA
    Genes Brain Behav 5:483-96. 2006
    ..Finally, these findings underscore the importance of determining the potential for rebound increases in withdrawal severity during later withdrawal episodes...
  15. ncbi Influence of ethanol withdrawal on fear memory: Effect of D-cycloserine
    M E Bertotto
    Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, Ciudad Universitaria 5000, Cordoba, Argentina
    Neuroscience 142:979-90. 2006
    ..The enhanced sensitivity to the facilitatory effect of DCS in ETOH withdrawn animals may be mediated by adaptive changes in N-methyl-D-aspartate (NMDA) receptor provoked by ETOH dependence...
  16. ncbi Regulation of alpha-synuclein expression in alcohol-preferring and -non preferring rats
    Tiebing Liang
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Neurochem 99:470-82. 2006
    ..These results suggest that regulation of rat Snca gene expression is complex and may contribute to alcohol preference in the iP rats...
  17. ncbi Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes
    Jennifer A Shumilla
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA, USA
    J Pain 6:535-49. 2005
    ..These studies demonstrate developmental differences in neonatal nociceptive responses after withdrawal from acute EtOH and implicate a role for specific PKC isozymes in EtOH withdrawal-associated allodynia and hyperalgesia...
  18. ncbi Impact of an intense stress on ethanol consumption in female rats characterized by their pre-stress preference: modulation by prenatal stress
    M Darnaudery
    Department of Neurosciences and Adaptive Physiology, Perinatal Stress Team, University of Lille 1, Bat SN4 1, 59655 Villeneuve d Ascq, France
    Brain Res 1131:181-6. 2007
    ..After footshock, control high-preferring rats strongly reduced their alcohol consumption; in contrast, alcohol consumption was not changed in high-preferring rats that were prenatally stressed...
  19. ncbi Prenatal alcohol exposure alters the size, but not the pattern, of the whisker representation in neonatal rat barrel cortex
    Cecilia P Margret
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center College of Medicine, 855 Monroe Avenue, Memphis, TN 38163, USA
    Exp Brain Res 165:167-78. 2005
    ..While these results might appear to support a miniaturization hypothesis (smaller PMBSF, smaller brain, smaller body weight), PAE also shows regional vulnerability within the PMBSF whereby anteriorly located barrels are most affected...
  20. pmc Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbens
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res 1134:148-61. 2007
    ....
  21. ncbi Attenuation of brain derived neurotrophic factor (BDNF) by ethanol and cytoprotective effect of exogenous BDNF against ethanol damage in neuronal cells
    R Sakai
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Neural Transm 112:1005-13. 2005
    ..Exogenous BDNF was shown to have a protective effect against ethanol-induced damage in primary culture neurons from rat hippocampi...
  22. ncbi Only high concentrations of ethanol affect GABAA receptors of rat cerebellum granule cells in culture
    S Casagrande
    Dipartimento di Fisica, Universita di Genova, Italy
    Neurosci Lett 414:273-6. 2007
    ..This result was unexpected. In fact, previous reports from other groups would have suggested high ethanol sensitivity of at least one population of GABAA receptors expressed by granule cells...
  23. ncbi Effect of hypothermia on blood-brain barrier permeability following traumatic brain injury in chronically ethanol-treated rats
    N Arican
    Department of Forensic Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Int J Neurosci 116:1249-61. 2006
    ..In ethanol-treated rats that were subjected to TBI, hypothermia led to a significant decrease in EB dye content in the brain at 24 h but not at 6 h after TBI when compared with TBI alone...
  24. ncbi Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultrastructure
    Xiaohua He
    Department of Pathology D06, University of Sydney, Sydney, NSW 2006, Australia
    Neuropsychopharmacology 32:2207-16. 2007
    ....
  25. ncbi AMPA receptors on developing medial septum/diagonal band neurons are sensitive to early postnatal binge-like ethanol exposure
    Shu Huei Hsiao
    Department of Medical Pharmacology and Toxicology, Texas A and M University System Health Science Center, College of Medicine MS 1114, College Station, TX 77843 1114, USA
    Brain Res Dev Brain Res 142:89-99. 2003
    ..Repeating this inhibition during early postnatal binge-like intoxication can augment normal development of AMPAR function...
  26. ncbi High temporal resolution of amino acid levels in rat nucleus accumbens during operant ethanol self-administration: involvement of elevated glycine in anticipation
    Zhimin Li
    Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32610, USA
    J Neurochem 106:170-81. 2008
    ..Thus, increases in glycine in nucleus accumbens appear to be related to anticipation of reinforcement...
  27. ncbi Chronic alcohol intoxication in rats leads to a strong but transient increase in NGF levels in distinct brain regions
    C A Gericke
    Institute of Health Sciences, Berlin University of Technology, Berlin, Germany
    J Neural Transm 113:813-20. 2006
    ..These results support the idea of an endogenous neuroprotective mechanism acting through a transient NGF induction followed by a decrease in NGF-levels during the course of further neuronal degeneration...
  28. ncbi Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Brain Res Dev Brain Res 133:115-26. 2002
    ....
  29. ncbi Ethanol activates cAMP response element-mediated gene expression in select regions of the mouse brain
    Asma Asyyed
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton St, Ste 200, Emeryville, CA 94608, USA
    Brain Res 1106:63-71. 2006
    ..Here, we use X-gal histochemistry to map CRE-mediated gene transcription in the brain of CRE-lacZ transgenic mice following ethanol injection...
  30. ncbi In vivo and in vitro ethanol exposure in prenatal rat brain: GABA(B) receptor modulation on dopamine D(1) receptor and protein kinase A
    H Y Lee
    Division of Life Science, College of Natural Sciences and Applied Life Science Brain Korea 21, Gyeongsang National University, Chinju 660 701, South Korea
    Synapse 62:534-43. 2008
    ..Therefore the present study suggested that the GABA(B)R activity could modulate ethanol's cellular effects, which possibly including PKA and DAD(1)R activities, and may be an underlying cause of ethanol's effects...
  31. ncbi Ethanol exposure during embryogenesis decreases the radial glial progenitorpool and affects the generation of neurons and astrocytes
    Gemma Rubert
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Neurosci Res 84:483-96. 2006
    ....
  32. ncbi Lack of evidence of a role for the neurosteroid allopregnanolone in ethanol-induced reward and c-fos expression in DBA/2 mice
    Niall P Murphy
    Neuronal Circuit Mechanisms Research Group, RIKEN Brain Science Institute, 2 1 Hirosawa, Wakoshi, Saitama 351 0198, Japan
    Brain Res 1094:107-18. 2006
    ..Together, these studies suggest that endogenous allopregnanolone plays little part in mediating acute ethanol-induced reward or neural activation in DBA/2 mice...
  33. ncbi Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Neuropsychopharmacology 32:1159-77. 2007
    ....
  34. ncbi Neurofunctional effects of developmental alcohol exposure in alcohol-preferring and alcohol-nonpreferring rats
    M Tattoli
    Department of Pharmacology and Human Physiology, University of Bari, Bari, Italy
    Neuropsychopharmacology 24:691-705. 2001
    ....
  35. ncbi Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus
    Cui Ping Chen
    Endocrine Program, Biomedical Division of the Center of Alcohol Studies and Department of Animal Sciences, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    J Neurochem 97:1026-33. 2006
    ..These data suggest for the first time that fetal exposure to ethanol significantly alters the clock mechanisms governing the circadian function of beta-endorphin neurons...
  36. ncbi GABAergic miniature postsynaptic currents in septal neurons show differential allosteric sensitivity after binge-like ethanol exposure
    Dustin W DuBois
    Department of Neuroscience and Experimental Therapeutics, College of Medicine MS 1114, Texas A and M System Health Science Center, College Station, TX 77843 1114, USA
    Brain Res 1089:101-15. 2006
    ..However, it is unlikely that ethanol causes a broad arrest of postsynaptic development through a direct inhibition of GABAAR signaling...
  37. ncbi Clinical correlates of quantitative EEG alterations in alcoholic patients
    Pedro Coutin-Churchman
    Hospital Psiquiátrico San Juan de Dios, Urb Campo Claro Los Curos, Edo Mérida 5101, Venezuela
    Clin Neurophysiol 117:740-51. 2006
    ..To evaluate the incidence and clinical correlations of abnormal QEEG features in alcoholic patients...
  38. ncbi Astrocyte-derived factors modulate the inhibitory effect of ethanol on dendritic development
    Penelope A Yanni
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York
    Glia 38:292-302. 2002
    ....
  39. ncbi Smooth endoplasmic reticulum dilation and degeneration in Purkinje neuron dendrites of aging ethanol-fed female rats
    Cynthia A Dlugos
    Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14214 3000, USA
    Cerebellum 5:155-62. 2006
    ..In addition, comparison of these results with data obtained in male rats from a previous study suggests that PN dendrites in females may be more sensitive to the effects of ethanol...
  40. ncbi Dopamine and N-methyl-D-aspartate receptor expression in peripheral blood of patients undergoing alcohol withdrawal
    T Biermann
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University, Erlangen Nuremberg, Germany
    J Neural Transm 114:1081-4. 2007
    ..A significant difference in D1 receptor expression (T = 2.361; p = 0.035) in terms of up-regulation could be shown, though there were no significant changes concerning D2, NMDA1 or NMDA2B receptor expression...
  41. pmc Ethanol-related increases in degenerating bodies in the Purkinje neuron dendrites of aging rats
    Cynthia A Dlugos
    Department of Pathology and Anatomical Sciences, 206 Farber Hall, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214 3000, USA
    Brain Res 1221:98-107. 2008
    ....
  42. ncbi NMDA receptor subunit expression following early postnatal exposure to ethanol
    Kimberly Nixon
    Department of Psychology, Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712, USA
    Brain Res Dev Brain Res 139:295-9. 2002
    ..There was no change in NR2B, thus suggesting that ethanol exposure during the third-trimester equivalent produces distinct effects on the NMDA receptor...
  43. ncbi Nicotine-induced changes of glutamate and arginine in naive and chronically alcoholized rats: an in vivo microdialysis study
    Frederic Lallemand
    Laboratoire de Biologie du Comportement, Universite Catholique de Louvain, 1 Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    Brain Res 1111:48-60. 2006
    ....
  44. ncbi Oxidative aggression in atherosclerosis associated to degenerative psychoorganic disturbances
    M Serban
    University of Medicine and Pharmacy Carol Davila Bucharest, Department of Pathophysiology and Immunology, Prof dr Al Obregia Hospital, 10, Sos Berceni, Bucharest
    Rom J Intern Med 40:117-23. 2002
    ..Generally, the antioxidant defense capacity of the old people organism is depressed, especially in the group with atherosclerosis associated with degenerative psychoorganic disturbances engendered by excessive and chronic alcohol intake...
  45. ncbi Ethanol withdrawal is accompanied by downregulation of calcium channel alpha 1B subunit in rat inferior colliculus neurons
    PROSPER N'GOUEMO
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20057, USA
    Brain Res 1108:216-20. 2006
    ..Thus, remodeling of N-type Ca(2+) channels may play an important role in neuronal hyperexcitability that leads to ethanol withdrawal seizures...
  46. ncbi Evidence for a female-specific effect of a chromosome 4 locus on anxiety-related behaviors and ethanol drinking in rats
    L F Vendruscolo
    Laboratoire de Neurogénétique et Stress, INRA Université Victor Segalen, Institut Francois Magendie, Bordeaux, France
    Genes Brain Behav 5:441-50. 2006
    ..These results suggest that Ofil1 contains either linked genes with independent influences on anxiety-related responses and ethanol drinking or a pleiotropic gene with simultaneous effects on both traits...
  47. ncbi Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Neurosci Lett 406:107-12. 2006
    ..In our sample IL-1A, IL-1B, TNF-alpha and HTTLPR do not appear as liability factors for alcohol toxicity or detoxification outcome, however the small sample size may influence the observed results...
  48. ncbi Universal precautions: a matter of mutual trust and responsibility
    Douglas Gourlay
    Pain Med 7:210-1; author reply 212. 2006
  49. ncbi The effects of ethanol intake and withdrawal on penicillin-induced epileptiform activity in rats
    Ramazan Kozan
    Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, 55139 Samsun, Turkey
    Brain Res Bull 71:111-5. 2006
    ..alpha-Tocopherol has anti-convulsive effect on penicillin-induced epileptiform activity in effective dose...
  50. pmc Neuroinflammation as a neurotoxic mechanism in alcoholism: commentary on "Increased MCP-1 and microglia in various regions of human alcoholic brain"
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA
    Exp Neurol 213:10-7. 2008
  51. pmc Association of alcohol consumption with brain volume in the Framingham study
    Carol Ann Paul
    Neuroscience Program, Wellesley College, 106 Central St, Wellesley, MA 02418, USA
    Arch Neurol 65:1363-7. 2008
    ..There is evidence that drinking large amounts of alcohol is related to brain atrophy. It is uncertain what the effects of low to moderate consumption might be...
  52. pmc Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current
    Doo Sup Choi
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:11890-9. 2008
    ..These findings indicate that PKCdelta contributes to a high level of behavioral response to ethanol, which is negatively associated with risk of developing an alcohol use disorder in humans...
  53. pmc Amygdala protein kinase C epsilon controls alcohol consumption
    H M B Lesscher
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA, USA
    Genes Brain Behav 8:493-9. 2009
    ..These mice have a >50% reduction in the abundance of PKCepsilon in the amygdala compared with wild-type mice. We conclude that amygdala PKCepsilon is important for ethanol consumption in mice...
  54. pmc Overexpression of glycogen synthase kinase 3beta sensitizes neuronal cells to ethanol toxicity
    Ying Liu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Neurosci Res 87:2793-802. 2009
    ..Our results indicate that GSK3beta may be a mediator of ethanol neurotoxicity, and its expression status in a cell may determine ethanol vulnerability...
  55. ncbi Dry beriberi mimicking the Guillain-Barre syndrome
    Christopher Murphy
    Greater Manchester Neuroscience Centre, Salford Royal Hospital, Stott Lane, Salford M6 8HD, UK
    Pract Neurol 9:221-4. 2009
    ..CSF was normal. He improved with high dose vitamin replacement and physiotherapy but remains dependent on a Zimmer frame for mobility and a splint for wrist drop...
  56. ncbi Prompt responses to the administration of ethanol in the treatment of the alcohol withdrawal syndrome (AWS)
    C M Fisher
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    Neurologist 15:242-4. 2009
    ..To report the beneficial effect of the administration of ethanol in the treatment of the alcohol withdrawal syndrome (AWS)...
  57. ncbi Early onset probable linezolid-induced encephalopathy
    Jeffery Fletcher
    Department of Neurology Neurocritical Care, Bronson Methodist Hospital, 601 John Street Suite M 124, Kalamazoo, MI 49007, USA
    J Neurol 257:433-5. 2010
    ..Clinicians should be aware of the potential for early onset linezolid-induced neurotoxicity, particularly in patients with concomitant risk factors...
  58. ncbi Research on alcohol and adolescent brain development: opportunities and future directions
    Ellen D Witt
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 9304, USA
    Alcohol 44:119-24. 2010
    ....
  59. ncbi Effectiveness and safety of baclofen in the treatment of alcohol dependent patients
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    CNS Neurol Disord Drug Targets 9:33-44. 2010
    ..g., baclofen's biobehavioral mechanisms, different baclofen doses, differences in severity and in alcoholic subtypes, different formulations of baclofen, possible combination of baclofen with other medications)...
  60. pmc Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis
    K Nixon
    Department of Pharmaceutical Sciences, The University of Kentucky, College of Pharmacy, 725 Rose Street, Lexington, KY 40536 0082, USA
    Neurobiol Dis 31:218-29. 2008
    ..This first report of microglia proliferation in a model of an AUD suggests that microgliosis could contribute to volume recovery in non-neurogenic regions during abstinence...
  61. ncbi Stimulated dopamine overflow and alpha-synuclein expression in the nucleus accumbens core distinguish rats bred for differential ethanol preference
    Anssi Pelkonen
    School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    J Neurochem 114:1168-76. 2010
    ..These results indicate that high expression of alpha-syn may contribute to the reduced DA overflow and the possible activation of re-uptake in the nucleus accumbens core of AA rats in comparison with ANA rats...
  62. ncbi Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains
    M K Mulligan
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX, USA
    Genes Brain Behav 7:677-89. 2008
    ..H2afz, Psen1, Wdfy1 and Clu were also identified as candidate genes that may be involved in influencing alcohol consumption...
  63. ncbi Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways
    Santiago Nahuel Villegas
    Molecular Biology, IMBICE, Camino Belgrano y 526, CC 403, 1900 La Plata, Argentina Instituto de Biofísica da UFRJ, CCS, Bloco G, Cidade Universitaria, 21949 900 Rio de Janeiro, Brazil
    Brain Res Bull 71:116-26. 2006
    ..These findings provide further insight into the mechanism involved in ethanol-induced apoptosis and the neurotrophic protection of glial cells...
  64. ncbi Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A1 and GABA(A) receptor systems
    M Saeed Dar
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Brain Res Bull 71:287-95. 2006
    ..e., GABA(A) at the granule cells and adenosine A(1) on axons and axonal terminals of the granule cells) and act as co-modulators of ethanol ataxia...
  65. ncbi An inverse relationship between typical alcohol consumption and facial symmetry detection ability in young women
    Kirsten A Oinonen
    Lakehead University, Thunder Bay, Ontario, Canada
    J Psychopharmacol 21:507-18. 2007
    ....
  66. ncbi Alcohol and adult neurogenesis: roles in neurodegeneration and recovery in chronic alcoholism
    Kimberly Nixon
    College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
    Hippocampus 16:287-95. 2006
    ..This review describes opposing neurogenic processes that occur with alcohol intoxication and abstinence following alcohol dependence and how these opposing events relate to neurodegeneration and recovery from chronic alcoholism...
  67. ncbi Ethanol regulation of D(1) dopamine receptor signaling is mediated by protein kinase C in an isozyme-specific manner
    Elizabeth B Rex
    Molecular Neuropharmacology Section, National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 33:2900-11. 2008
    ..These findings suggest that ethanol inhibits the activities of specific PKC isozymes, resulting in decreased D(1) receptor phosphorylation and enhanced dopaminergic signaling...
  68. ncbi Cognitive impairment in Aboriginal people with heavy episodic patterns of alcohol use
    Sheree Cairney
    Menzies School of Health Research and Charles Darwin University, Casuarina, NT, Australia
    Addiction 102:909-15. 2007
    ....
  69. ncbi Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors
    Daniel K Crawford
    Alcohol and Brain Research Laboratory, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Neurochem 102:2097-109. 2007
    ....
  70. ncbi Cerebellar granule cell migration and the effects of alcohol
    Yulan Jiang
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Dev Neurosci 30:7-23. 2008
    ..Third, we will review the roles of external guidance cues and transmembrane signals in granule cell migration. Finally, we will reveal mechanisms by which alcohol exposure impairs granule cell migration...
  71. ncbi Acute ethanol induces Fos in GABAergic and non-GABAergic forebrain neurons: a double-labeling study in the medial prefrontal cortex and extended amygdala
    M Leriche
    Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada Mexico Xochimilco 101, Col San Lorenzo Huipulco, 14370 México DF, Mexico
    Neuroscience 153:259-67. 2008
    ..In contrast, in the prelimbic cortex, 75% of Fos-immunoreactive neurons were not GABAergic. These results constitute new evidence for region-specific functional interactions between ethanol and GABAergic neurons...
  72. ncbi Genetic dissection of quantitative trait locus for ethanol sensitivity in long- and short-sleep mice
    B Bennett
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Genes Brain Behav 7:659-68. 2008
    ..Genetic background effects can be important in detection of single QTL; combining this information with the generation of congenics on both backgrounds, as described here, is a powerful approach for fine mapping QTL...
  73. ncbi The role of topiramate and other anticonvulsants in the treatment of alcohol dependence: a clinical review
    Avinash De Sousa
    Carmel, 18, St Francis Avenue, Off S V Road, Santacruz West, Mumbai 400054, Maharashtra, India
    CNS Neurol Disord Drug Targets 9:45-9. 2010
    ....
  74. ncbi Ethanol-induced alteration in N-methyl-D-aspartate receptor 2A C-terminus and protein kinase C activity in rat brain
    Rukhsana Sultana
    Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India
    Neurosci Lett 349:45-8. 2003
    ..Our current findings imply that the truncation of NR2A subunit upon alcohol administration in cerebellum probably contributes to altered NMDA receptor function and cerebellar atrophy and motor incoordination in alcoholic rats...
  75. ncbi Disruption of cholesterol homeostasis in the developing brain as a potential mechanism contributing to the developmental neurotoxicity of ethanol: an hypothesis
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, Toxicology Program, University of Washington, Seattle, WA 98105, USA
    Med Hypotheses 64:563-7. 2005
    ....
  76. ncbi Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells
    Mia Ericson
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci Res 73:722-30. 2003
    ....
  77. ncbi Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcohol
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:1048-55. 2006
    ..The lack of interaction indicated that the CNS stimulant effects of MDMA were never sufficient to overcome alcohol-induced impairment of impulse control or risk-taking behavior...
  78. ncbi Role of caspase-3 in ethanol-induced developmental neurodegeneration
    Chainllie Young
    Department of Psychiatry, Campus Box 8134, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Neurobiol Dis 20:608-14. 2005
    ..We conclude that absence of functional caspase-3 alters the time course and morphological characteristics of the neurodegenerative process but does not prevent ethanol-induced neuron death...
  79. ncbi Marchiafava-Bignami disease: diffusion-weighted MRI in corpus callosum and cortical lesions
    P Menegon
    Service de Neuroradiologie, Hopital Pellegrin, CHU Bordeaux, France
    Neurology 65:475-7. 2005
    ..They show that apparent diffusion coefficient restriction of the corpus callosum and cortical lesions were associated with a higher mortality rate and more severe cognitive sequelae...
  80. ncbi Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:988-96. 2006
    ..These data indicate that CET induces reversible neuroadaptations in synaptic function, gene expression, and protein composition of NMDAR at CeA synapses...
  81. ncbi Differences in brain area concentrations of dopamine and serotonin in Myers' High Ethanol Preferring (mHEP) and outbred rats
    L A C Lucas
    Department of Pharmacology, and Center for Alcohol and Drug Abuse Studies, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    J Neural Transm 109:279-92. 2002
    ..Differences in neurotransmitter function in these brain areas may account for some of the behavioral differences previously demonstrated between the two sexes of the mHEP rat...
  82. pmc Signaling cascades regulating NMDA receptor sensitivity to ethanol
    Dorit Ron
    Department of Neurology, University of California, San Francisco, Ernest Gallo Clinic and Research Center, Emeryville 94608, USA
    Neuroscientist 10:325-36. 2004
    ..Specifically, the role of the scaffolding protein RACK1 and the regulatory protein DARPP-32 in mediating the distinct effects of ethanol is presented...
  83. ncbi [Neuropsychological deficits in alcoholics: some implications for road safety]
    M J Garrido
    Departamento de Psicología Básica II, Universidad Complutense, Madrid, Espana
    Rev Neurol 38:277-83. 2004
    ..We also will analyse the involvement of these deficit in a complex task as driving...
  84. ncbi Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat
    Cui Ping Chen
    Endocrine Program, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    J Neurochem 88:1547-54. 2004
    ..Our findings identified the vulnerability of the body's clock machinery and its opioidergic system to chronic alcohol drinking...
  85. ncbi Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals
    Stefan Bleich
    Neurology 60:1220; author reply 1220. 2003
  86. ncbi Alpha-lipoic acid prevents ethanol-induced protein oxidation in mouse hippocampal HT22 cells
    Matthias Pirlich
    Department of Gastroenterology and Hepatology, University Hospital Charite, Humboldt University Berlin, Schumannstr 20 21, 10098, Berlin, Germany
    Neurosci Lett 328:93-6. 2002
    ..These results indicate that the radical scavenging properties of LC are effective to ameliorate ethanol-induced neurotoxicity...
  87. ncbi Effects of 4-methylpyrazole on ethanol neurobehavioral toxicity in CD-1 mice
    Ana Maria Páez
    Division of Emergency Medicine and the Program in Clinical Pharmacology Toxicology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 11:820-6. 2004
    ..This was a study to determine whether ADH blockade with 4-MP prolongs ethanol neurobehavioral toxicity in a murine model...
  88. ncbi A 47-year-old alcoholic man with progressive abnormal gait
    Scott A McHam
    Department of General Internal Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Cleve Clin J Med 69:904-8. 2002
    ..Supportive care is important to prevent complications, but no treatment has been found to be effective in treating the illness. Patient outcomes vary considerably and are difficult to predict...
  89. ncbi [Radiological findings of brain, connected to alcohol overuse]
    Michaela K Bode
    Duodecim 122:315-23. 2006
  90. ncbi [Reversible demyelinisation of corpus callosum in the course of Marchiafava-Bignami disease]
    Jacek Staszewski
    Klinika Neurologii CSK WAM, Wojskowy Instytut Medyczny, Ul Szaserow 128, 00 909 Warszawa 60
    Neurol Neurochir Pol 40:156-61. 2006
    ..Control MRI scans revealed remyelinisation of the corpus callosum. Hence, this technique proved itself to be useful in monitoring the course of the disease...
  91. ncbi [Neurologic sequelae of chronic alcoholism]
    E Hund
    Neurologische Klinik, Ruprecht Karls Universitat Heidelberg
    Anaesthesiol Reanim 28:4-7. 2003
    ..In daily practice, it is important to differentiate these disorders when encountering patients with chronic alcohol abuse...
  92. ncbi Ethanol withdrawal and hyperalgesia
    Michael B Gatch
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Curr Drug Abuse Rev 2:41-50. 2009
    ..Clinical research is essential to determine the significance of the hyperalgesia to the severity of withdrawal and to relapse...
  93. ncbi Differential activation of face memory encoding tasks in alcohol-dependent patients compared to healthy subjects: an fMRI study
    Hyo Woon Yoon
    Neuroscience Research Institute, Gachon University of Medicine and Science, 1198 Kuwol dong, Namdong gu, Incheon, Republic of Korea
    Neurosci Lett 450:311-6. 2009
    ..However, the absence of right hemispheric lateralization in alcohol-dependent patients is consistent with the hypothesis that the right hemisphere is more vulnerable to alcohol-related damage than the left hemisphere...
  94. ncbi Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice
    H Houchi
    Equipe Région INSERM 24, Groupe de Recherche sur l Alcool et les Pharmacodépendances, Universite de Picardie Jules Verne, Faculte de Pharmacie, Amiens, France
    Genes Brain Behav 7:887-98. 2008
    ....
  95. ncbi Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat
    Maria Pascual
    Department of Cellular Pathology, Valencia, Spain
    J Neurochem 108:920-31. 2009
    ....
  96. ncbi A protein kinase C activity localized to neuropeptide Y-like neurons mediates ethanol intoxication in Drosophila melanogaster
    J Chen
    The Department of Cellular Biology, and Biomedical and Health Sciences Institute, 500 D W Brooks Drive, University of Georgia, Athens, GA 30602, USA
    Neuroscience 156:42-7. 2008
    ..These findings reveal an uncharacterized role of PKC in NPY/NPF-mediated acute ethanol sensitivity in flies and possibly mammals...
  97. pmc Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state
    Heather N Richardson
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Neurosci 28:1641-53. 2008
    ....
  98. ncbi The enigma of fetal alcohol neurotoxicity
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Med 34:109-19. 2002
    ....
  99. pmc The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice
    Katherine R Gililland-Kaufman
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Brain Res 1243:113-23. 2008
    ....
  100. ncbi Aripiprazole: a drug with a novel mechanism of action and possible efficacy for alcohol dependence
    Derick E Vergne
    Center for Drugs and Alcohol Programs, Department of Psychiatry, Medical University of South Carolina, USA
    CNS Neurol Disord Drug Targets 9:50-4. 2010
    ..g., those with impulsive disorders), or non-responsive to available treatments. Early results with aripiprazole are promising and warrant further exploration...
  101. ncbi Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat
    K E Light
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Neuroscience 114:327-37. 2002
    ..Furthermore, the initiation of apoptosis by ethanol is consistent with ethanol-induced interruptions of Purkinje cell neurotrophic support leading to activation of the mitochondrial pathway of apoptosis...

Research Grants44

  1. DEVELOPMENTAL BRAIN DAMAGE BY DRUGS OF ABUSE
    John W Olney; Fiscal Year: 2010
    ..abstract_text> ..
  2. ACUTE BRAIN INJURY, MECHANISMS AND PROTECTION
    John Olney; Fiscal Year: 2001
    ..The long term goals are to clarify the underlying mechanisms and develop improved methods of treating human pediatric acute brain injury conditions. ..
  3. NEUROPROTECTION AGAINST RETINAL ISCHEMIA
    John Olney; Fiscal Year: 2001
    ..These studies will be conducted studies using Muller cell cultures to test this hypothesis. ..
  4. Transdermal Cannabidiol Delivery for Alcohol-Induced Neurodegeneration
    Kimberly Nixon; Fiscal Year: 2007
    ..Cannabidiol administration in the appropriate delivery system has these benefits as a lead candidate in the search for novel alcoholism pharmacotherapies. [unreadable] [unreadable] [unreadable]..
  5. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2004
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  6. Brain Tissue Resource Centre for Alcohol Research
    Clive Harper; Fiscal Year: 2007
    ..Funding is sought to help further develop this important resource for international researchers with an interest in alcohol-related brain damage. ..
  7. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  8. IL-6 Regulation of Hippocampal Synaptic Function
    Donna L Gruol; Fiscal Year: 2010
    ..The proposed studies focus on this issue as it relates to CNS disorders. ..
  9. Neurobehavioral Consequences of Adolescent Alcohol
    Cindy Ehlers; Fiscal Year: 2008
    ..AIM 3: To investigate the neurochemical substrates underlying the lasting neurobehavioral consequences of adolescent ethanol exposure, with a focus on NMDA systems ..
  10. Cannabinoid Receptor Function in Alcoholism: Effects of D-9-THC
    DEEPAK D SOUZA; Fiscal Year: 2008
    ..These results may reflect indirect evidence of altered CB-1R function in FHP individuals. [unreadable] [unreadable] [unreadable]..
  11. Ethanol Effects in the Mammalian Circadian Clock
    Rebecca Prosser; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Alcohol And Mitochondrial Redistribution in Neurons
    Shivani Maffi; Fiscal Year: 2006
    ..Hence, the information gathered will have implications to our future understanding of the role of mitochondrial motility in homeostasis and [unreadable] disease states. [unreadable] [unreadable]..
  13. MATERNAL ALCOHOLISM AND CNS DEVELOPMENT IN OFFSPRING
    MARY DRUSE MANTEUFFEL; Fiscal Year: 2007
    ..Analyses will include western blot analyses, real-time quantitative RT-PCR, fluorescence and light microscopy, immunohistochemistry, and enzyme assays. ..
  14. ALCOHOLISM AND ENDOGENOUS OPIOID ACTIVITY
    Gary Wand; Fiscal Year: 2008
    ..Fortype specifications, see instructions onpage 6.) RESEARCH GRANT TABLE OF CONTENTS PageNumbers Face Page 1 Description, ..
  15. ADOLESCENT MARIJUANA USE IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2008
    ..abstract_text> ..
  16. Perioculomotor area and alcohol
    Andrey E Ryabinin; Fiscal Year: 2010
    ..These studies will provide novel important information indicating how these recently identified neurons robustly regulate alcohol intake. ..
  17. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2009
    ..abstract_text> ..
  18. NEUROBIOLOGY OF CANNABIS EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2009
    ....
  19. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2008
    ..abstract_text> ..
  20. Epigenetics of fetal alcohol syndrome
    Feng Zhou; Fiscal Year: 2009
    ..The effect of these epigenetic key genes will be confirmed in the in vivo model exposed to alcohol vapor chamber with alcohol exposure pattern and paradigms similar to the whole embryonic culture. ..
  21. Cannabinoids, Neural Synchrony and Information Processing
    DEEPAK D SOUZA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  22. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  23. Sphingolipids in Ethanol-Induced Neuronal Apoptosis
    Mariko Saito; Fiscal Year: 2010
    ..These studies will reveal the functions of sphingolipids in ethanol-induced apoptosis in the developing brain, and will offer bases for future therapeutic strategies for FASD. ..
  24. The Effects of Neuroactive Steroids on Acute Ethanol Withdrawal in Mice
    KATHERINE GILILLAND; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. ALCOHOL & DEVELOPMENT:EFFECTS ON CEREBELLAR SYSTEMS
    Charles Goodlett; Fiscal Year: 2007
    ..guide and inform future studies of effects of prenatal alcohol exposure in infants and children, because the behavioral procedures and neural circuits underlying eyeblink conditioning are similar in both species [unreadable] [unreadable]..
  26. The Lateral Septum, Urocortin and Alcohol
    ADAM WEITEMIER; Fiscal Year: 2004
    ..Findings of this proposal will provide an important contribution to work highlighting the importance of stress- and anxiety-modulating neuropeptide systems in the regulation of alcohol-related behaviors. ..
  27. EPIDEMIOLOGY OF DEMENTIA: A PROSPECTIVE COMMUNITY STUDY
    Mary Ganguli; Fiscal Year: 2002
    ....
  28. Neuroanatomical adaptation at synaptic level to chronic
    Feng Zhou; Fiscal Year: 2003
    ..The setting of this threshold might be derailed when alcohol is cyclically deprived. Current and future study along this line will provide information enabling us to better understanding excess drinking behavior. ..
  29. MECHANISMS OF PRENATAL COCAINE AND ETHANOL TOXICITY
    Ellen Mitchell; Fiscal Year: 2003
    ..In addition, we will assess exposed pups for susceptibility to further hypoxia at birth and monitor physiological differences after they reach adulthood. ..
  30. CLINICAL EPIDEMIOLOGY OF DEMENTIA IN GENERAL PRACTICE
    Mary Ganguli; Fiscal Year: 2003
    ..They will also assist in formulating appropriate policies and guidelines for early diagnosis, treatment, and prevention of excess disability. ..
  31. ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS
    Feng Zhou; Fiscal Year: 2003
    ....
  32. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
    ..Pilot data (n=12) towards this proposal suggests that glycine reduces ketamine-induced perceptual alterations, negative symptoms and impairments on recall without worsening positive symptoms. ..
  33. CYTOKINE/CHEMOKINE ACTIONS ON DEVELOPING CNS NEURONS
    DONNA GRUOL; Fiscal Year: 2002
    ....
  34. NEUROANATOMICAL SUBSTRATES OF ALCOHOL-INDUCED AMNESIA
    Andrey Ryabinin; Fiscal Year: 2001
    ..Taken together, these studies will provide valuable insight at several levels of analysis of alcohol~s action on cognitive functions and eventually allow to start understanding of the mechanisms involved in alcohol-induced amnesia. ..
  35. RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2006
    ..The identification of such variables may potentially be useful in the development of specific prevention and treatment programs for this population as well as other Native American tribes. ..
  36. TESTING FASD THERAPEUTIC AGENTS: NEONATAL RODENT MODELS
    Charles Goodlett; Fiscal Year: 2005
    ..A key advantage of integrated approaches across the Consortium is that as promising candidate molecular agents emerge, these animal models can provide in vivo tests of their therapeutic effectiveness. ..
  37. Voltammetry in Freely Moving Mice
    Sara Jones; Fiscal Year: 2005
    ..There are many applications of these measurements to addiction research in the future, including, for example, monitoring other neurotransmitters and using genetically altered or recombinant inbred mouse strains. ..
  38. Ethanol, NMDA Receptor and Dopamine Interactions
    Sara Jones; Fiscal Year: 2006
    ..From these studies we hope to gain insights into the receptor mechanisms involved in alcohol action. ..
  39. Somatic Ca2+ Signaling in CNS Neurons
    DONNA GRUOL; Fiscal Year: 2007
    ..However, the general principles identified by the studies will also contribute significantly to our understanding of the role of activity-dependent gene expression during development in other CNS neuronal types. [unreadable] [unreadable]..
  40. Alcoholism risk and protective factors in Trinidad
    Cindy Ehlers; Fiscal Year: 2006
    ..Study findings can be compared to similar studies being conducted in the US. We believe these studies will allow for the identification of risk and protective factors for alcoholism in these islands. [unreadable] [unreadable]..
  41. Ethanol and cholesterol homeostasis in the brain
    Marina Guizzetti; Fiscal Year: 2006
    ..abstract_text> ..
  42. Inhibition of Alcohol Intake by Non-opioid Peptide
    GARTH RESCH; Fiscal Year: 2005
    ....
  43. NEURONAL ACTIONS OF HOST FACTORS IN NEUROAIDS
    DONNA GRUOL; Fiscal Year: 2005
    ..The overall design will address effects of both acute and chronic chemokine exposure on neuronal cell function and will include examination of two distinct classes of neurons, excitatory glutamatergic and inhibitory GABAergic neurons. ..