neurotoxicity syndromes

Summary

Summary: Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.

Top Publications

  1. ncbi Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity
    Bo Jiang
    School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China
    Neurol Res 30:639-44. 2008
  2. ncbi Oxaliplatin-induced neurotoxicity: changes in axonal excitability precede development of neuropathy
    Susanna B Park
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Brain 132:2712-23. 2009
  3. ncbi Developmental neurotoxicity of industrial chemicals
    P Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Lancet 368:2167-78. 2006
  4. pmc Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption
    Kathryn R Mahaffey
    Department of Occupational and Environmental Health, George Washington University School of Public Health, Washington DC, USA
    Nutr Rev 69:493-508. 2011
  5. ncbi Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment
    David M Soderlund
    Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
    Toxicology 171:3-59. 2002
  6. pmc Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs
    Timothy J Shafer
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 113:123-36. 2005
  7. ncbi Poisoning due to pyrethroids
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre, City Hospital, UK
    Toxicol Rev 24:93-106. 2005
  8. pmc Safety analysis of FOLFOX4 treatment in colorectal cancer patients: a comparison between two Asian studies and four Western studies
    Kenichi Sugihara
    Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Colorectal Cancer 11:127-37. 2012
  9. ncbi Oxaliplatin-related neurotoxicity: how and why?
    Lara Maria Pasetto
    Medical Oncology Division, Azienda Ospedale Universita, Via Gattamelata 64, Padova, Italy
    Crit Rev Oncol Hematol 59:159-68. 2006
  10. ncbi Neurobehavioral toxicology of pyrethroid insecticides in adult animals: a critical review
    M J Wolansky
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 30:55-78. 2008

Research Grants

Detail Information

Publications253 found, 100 shown here

  1. ncbi Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity
    Bo Jiang
    School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China
    Neurol Res 30:639-44. 2008
    ..DA turnover in MPTP mice was reversed in the nigrostriatal pathway. In conclusion, data obtained in the above study suggested that catalpol exerted neuroprotective action in vitro and in vivo PD model...
  2. ncbi Oxaliplatin-induced neurotoxicity: changes in axonal excitability precede development of neuropathy
    Susanna B Park
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Brain 132:2712-23. 2009
    ..05) than those left with mild or moderate neurotoxicity, suggesting that assessment of sensory excitability parameters may provide a sensitive biomarker of severity for oxaliplatin-induced neurotoxicity...
  3. ncbi Developmental neurotoxicity of industrial chemicals
    P Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Lancet 368:2167-78. 2006
    ..New, precautionary approaches that recognise the unique vulnerability of the developing brain are needed for testing and control of chemicals...
  4. pmc Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption
    Kathryn R Mahaffey
    Department of Occupational and Environmental Health, George Washington University School of Public Health, Washington DC, USA
    Nutr Rev 69:493-508. 2011
    ..A framework for providing dietary advice for women of childbearing age on how to maximize the dietary intake of n-3 PUFAs while minimizing MeHg exposures is suggested...
  5. ncbi Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment
    David M Soderlund
    Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
    Toxicology 171:3-59. 2002
    ....
  6. pmc Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs
    Timothy J Shafer
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 113:123-36. 2005
    ..These studies should employ state-of-the-science methods to promote a greater understanding of the mode of action of pyrethroids in the developing nervous system...
  7. ncbi Poisoning due to pyrethroids
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre, City Hospital, UK
    Toxicol Rev 24:93-106. 2005
    ..Management is supportive. As paraesthesiae usually resolve in 12-24 hours, specific treatment is not generally required, although topical application of dl-alpha tocopherol acetate (vitamin E) may reduce their severity...
  8. pmc Safety analysis of FOLFOX4 treatment in colorectal cancer patients: a comparison between two Asian studies and four Western studies
    Kenichi Sugihara
    Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Colorectal Cancer 11:127-37. 2012
    ..As part of the Japanese submission for the adjuvant indication, the safety profile of FOLFOX4 regimen was compared in Asian and Western patients...
  9. ncbi Oxaliplatin-related neurotoxicity: how and why?
    Lara Maria Pasetto
    Medical Oncology Division, Azienda Ospedale Universita, Via Gattamelata 64, Padova, Italy
    Crit Rev Oncol Hematol 59:159-68. 2006
    ..The aim of this review is to analyse the mechanism underlying induction of neurotoxicity and the possible treatments to prevent and to treat it...
  10. ncbi Neurobehavioral toxicology of pyrethroid insecticides in adult animals: a critical review
    M J Wolansky
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 30:55-78. 2008
    ..For risk assessment purposes, a strategy that takes into account data from an array of neurobehavioral endpoints is needed to capture the heterogeneity of pyrethroid-induced adverse effects and accurately inform policy decisions...
  11. ncbi Acrylamide: review of toxicity data and dose-response analyses for cancer and noncancer effects
    A Shipp
    ENVIRON International Corporation, 602 East Georgia Street, Ruston, LA 07290, USA
    Crit Rev Toxicol 36:481-608. 2006
    ..However, it should be noted that although this review was intended to be comprehensive, it is not exhaustive, as new data are being published continuously...
  12. ncbi Strategies and tools for preventing neurotoxicity: to test, to predict and how to do it
    Jordi Llorens
    Department of Physiological Sciences II, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain
    Neurotoxicology 33:796-804. 2012
    ....
  13. ncbi Practical considerations on the design, execution and analysis of developmental neurotoxicity studies to be published in Neurotoxicology and Teratology
    Jacques Maurissen
    The Dow Chemical Company, Toxicology and Environmental Research and Consulting, 1803 Bldg, Midland, MI 48674, USA
    Neurotoxicol Teratol 32:121-3. 2010
    ..g., litter), addressing the results of all analyses (e.g., "negative" results are important). Data interpretation should be evidence-based and not exceed the limits of the findings...
  14. ncbi Cerebrovascular damage in young rabbits after intravenous administration of Shiga toxin 2
    M Mizuguchi
    Department of Pediatrics, Jichi Medical School, Tochigi, Japan
    Acta Neuropathol 102:306-12. 2001
    ..Given our results, we conclude that the cerebral blood vessels of immature brains are more vulnerable to Stx2 than those of adults in the rabbit...
  15. ncbi Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides
    Charles B Breckenridge
    Syngenta Crop Protection Inc, P O Box 18300, Greensboro, NC 27419 8300, USA
    Neurotoxicology 30:S17-31. 2009
    ..Fenpropathrin and esfenvalerate occupy an intermediate position between these two groups...
  16. ncbi A reassessment of the neurotoxicity of pyrethroid insecticides
    David E Ray
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Pharmacol Ther 111:174-93. 2006
    ..The evidence for these is at present equivocal, but all 3 carry important implications for human health...
  17. pmc Intravenous calcium and magnesium for oxaliplatin-induced sensory neurotoxicity in adjuvant colon cancer: NCCTG N04C7
    Axel Grothey
    Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Clin Oncol 29:421-7. 2011
    ..In a nonrandomized, retrospective study, intravenous (IV) calcium/magnesium (Ca/Mg) was associated with reduced oxaliplatin-induced sNT...
  18. ncbi Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms
    Johnalyn Lyles
    Molecular Neuropsychiatry Branch, National Institutes of Health National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 42:155-68. 2003
    ..Much remains to be done in order to clarify the molecular and biochemical pathways involved in the long-term neuroplastic changes associated with MDMA abuse...
  19. ncbi Neurotoxicity of pesticides: a brief review
    Lucio G Costa
    Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Front Biosci 13:1240-9. 2008
    ..This brief review highlights some of the main neurotoxic pesticides, their effects, and mechanisms of action...
  20. ncbi Neurodevelopmental toxicity risks due to occupational exposure to industrial chemicals during pregnancy
    Jordi Julvez
    Department of Environmental Health, Harvard School of Public Health, Landmark Building 3E 110, 401 Park Drive, Boston, MA 02215, USA
    Ind Health 47:459-68. 2009
    ..Due to the vulnerability of the brain during early development, a precautionary approach to neurodevelopmental toxicity needs to be applied in occupational health...
  21. ncbi Neuropathy in an artist exposed to organic solvents in paints: a case study
    Shlomo Moshe
    Hashfela Occupational Medicine Unit, Maccabi Medical Services, Yavne, Israel
    Arch Environ Health 57:127-9. 2002
    ..The authors were unable to find any similar case report in the literature...
  22. ncbi Analysis and integration of developmental neurotoxicity and ancillary data into risk assessment: a case study of dimethoate
    John M DeSesso
    Noblis, Falls Church, Virginia 22042, USA
    J Toxicol Environ Health A 72:94-109. 2009
    ....
  23. ncbi Ganglioside GM1 (porcine) ameliorates paclitaxel-induced neuropathy in rats
    Vilai Chentanez
    Peripheral Nerve Research Unit, Department ofAnatomy, Faculty of Medicine, Chulalongkorn University, Bangkok
    J Med Assoc Thai 92:50-7. 2009
    ..Monosialic acid ganglioside (GM1) has been shown to protect neurons against injuries and degeneration. However, its efficacy in the treatment of paclitaxel-induced neuropathy has not been verified...
  24. ncbi Organophosphorus ester-induced chronic neurotoxicity
    Mohamed B Abou-Donia
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Arch Environ Health 58:484-97. 2003
    ....
  25. ncbi Assessing the effects of environmental toxicant exposure in developmental epidemiological studies: issues for risk assessment
    Deborah C Rice
    Environmental Health Unit, Maine Bureau of Health, State House Station 11, Augusta, ME 04333, USA
    Neurotoxicology 26:483-9. 2005
    ..Opportunity for discussion among investigators, statisticians, and risk assessors potentially would result in human developmental toxicity studies being maximally useful for public health decisions...
  26. pmc Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts
    Christoph van Thriel
    Neurobehavioural Toxicology and Chemosensation, IfADo Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Neurotoxicology 33:911-24. 2012
    ..We envision that future in vitro test systems for developmental neurotoxicity will combine the above approaches with exposure information, and we suggest a strategy for test system development and cell-based risk assessment...
  27. ncbi Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Nat Rev Neurosci 8:766-75. 2007
    ..In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic...
  28. pmc Role of the Nrf2-ARE pathway in acrylamide neurotoxicity
    Lihai Zhang
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467 2490, United States
    Toxicol Lett 205:1-7. 2011
    ..Because a cytoprotective response was not induced in any fraction, nerve terminal vulnerability to ACR cannot be ascribed to the absence of transcription-based defense mechanisms in this neuronal region...
  29. ncbi The ABCB1-1Delta mutation is not responsible for subchronic neurotoxicity seen in dogs of non-collie breeds following macrocyclic lactone treatment for generalized demodicosis
    Stéphane Bissonnette
    Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, St Hyacinthe, Quebec, Canada
    Vet Dermatol 20:60-6. 2009
    ....
  30. ncbi Comparative functional observational battery study of twelve commercial pyrethroid insecticides in male rats following acute oral exposure
    Myra L Weiner
    TOXpertise, LLC, Princeton, NJ 08540, USA
    Neurotoxicology 30:S1-16. 2009
    ..Group 2 would include cypermethrin, deltamethrin, esfenvalerate, beta-cyfluthrin and lambda-cyhalothrin. Fenpropathrin exhibited features of both groups...
  31. ncbi Application of silver degeneration stains for neurotoxicity testing
    R C Switzer
    Neuroscience Associates, Knoxville, Tennessee 37922, USA
    Toxicol Pathol 28:70-83. 2000
    ..Other newly developed silver methods have been refined to show nondisintegrative degeneration, such as the plaques,and tangles of Alzheimer's disease...
  32. ncbi Amelioration of oxaliplatin neurotoxicity by drugs in humans and experimental animals: a minireview of recent literature
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine, Sultan Qaboos University, Sultanate of Oman
    Basic Clin Pharmacol Toxicol 106:272-9. 2010
    ..None of these drugs have been proven to be effective in large, controlled, clinical trials...
  33. ncbi Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 rats
    Joan Garey
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72211, United States
    Neurotoxicol Teratol 32:220-5. 2010
    ....
  34. ncbi Integration of epidemiology and animal neurotoxicity data for risk assessment
    Abby A Li
    Exponent Health Sciences, Menlo Park, CA 94025, USA
    Neurotoxicology 33:823-32. 2012
    ....
  35. ncbi Use of calcium and magnesium salts to reduce oxaliplatin-related neurotoxicity
    Howard S Hochster
    J Clin Oncol 25:4028-9. 2007
  36. pmc Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases
    Richard M LoPachin
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10467 2490, USA
    Toxicol Sci 104:235-49. 2008
    ....
  37. pmc Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology Box 3813, Duke University Medical Center, Durham, NC 27710, USA
    Toxicol Appl Pharmacol 233:211-9. 2008
    ....
  38. ncbi Interpretation of small effect sizes in occupational and environmental neurotoxicology: individual versus population risk
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Farley Basement Box 127, 300 Longwood Avenue, Boston, MA 02115, USA
    Neurotoxicology 28:245-51. 2007
    ....
  39. ncbi Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: a randomized, double-blind, placebo-controlled trial
    Stefano Cascinu
    Department of Medical Oncology, Azienda Ospedaliera Universitaria di Parma, Via Gramsci 14, 43100 Parma, Italy
    J Clin Oncol 20:3478-83. 2002
    ..We performed a randomized, double-blind, placebo-controlled trial to assess the efficacy of glutathione (GSH) in the prevention of oxaliplatin-induced neurotoxicity...
  40. pmc Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer
    Gregory D Leonard
    Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Naval Medical Center, Bethesda, MD 20889 5105, USA
    BMC Cancer 5:116. 2005
    ..Oxaliplatin, an agent used in first-line therapy for metastatic colorectal cancer, causes acute and chronic neurotoxicity. This study was performed to carefully assess the incidence, type and duration of oxaliplatin neurotoxicity...
  41. ncbi The use of developmental neurotoxicity data in pesticide risk assessments
    Kathleen C Raffaele
    Office of Research and Development, U S Environmental Protection Agency, 1200 Pennsylvania Ave, Washington, DC 20460, USA
    Neurotoxicol Teratol 32:563-72. 2010
    ....
  42. ncbi Oxaliplatin and axonal Na+ channel function in vivo
    Arun V Krishnan
    Institute of Neurological Sciences, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Clin Cancer Res 12:4481-4. 2006
    ..The aim of the study was to investigate the pathophysiology of oxaliplatin-induced neurotoxicity using clinical nerve excitability techniques that provide information about axonal ion channel function...
  43. ncbi Quantification and localization of kainic acid-induced neurotoxicity employing a new biomarker of cell death: cleaved microtubule-associated protein-tau (C-tau)
    F P Zemlan
    Department of Psychiatry, College of Medicine, 231 Sabin Avenue, University of Cincinnati, Cincinnati, OH 45267, USA
    Neuroscience 121:399-409. 2003
    ..These data suggest that C-tau proteolysis may prove a reliable species independent biomarker of neuronal degeneration regardless of source of injury...
  44. pmc Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins
    Ripon Paul
    MIND Institute, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Neurotoxicology 31:399-402. 2010
    ....
  45. ncbi Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants
    Richard M LoPachin
    Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467 2490, USA
    Toxicol Sci 94:240-55. 2006
    ..The proposed mechanism of electrophilic neurotoxicants represents a new and exciting experimental framework for mechanistic research in human neuropathological conditions associated with toxicant exposure or disease-based processes...
  46. ncbi Hypothesis-based weight-of-evidence evaluation of the neurodevelopmental effects of chlorpyrifos
    Robyn L Prueitt
    Gradient, Cambridge, Massachusetts 02138, USA
    Crit Rev Toxicol 41:822-903. 2011
    ....
  47. ncbi Prevention of oxaliplatin-induced peripheral sensory neuropathy by carbamazepine in patients with advanced colorectal cancer
    Christian Lersch
    II Medical Hospital and Health Center, Technischen Universitat Munchen, Klinikum rechts der Isar, Ismaninger St 22, 81675 Munich, Germany
    Clin Colorectal Cancer 2:54-8. 2002
    ..Randomized clinical studies are necessary to confirm the potential benefit of carbamazepine and other sodium channel blockers in preventing and/or overcoming the development of oxaliplatin-induced neurotoxicity...
  48. ncbi Assessing environmental neurotoxicant exposures and child neurobehavior: confounded by confounding?
    David C Bellinger
    Department of Neurology Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Epidemiology 15:383-4. 2004
  49. ncbi Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity
    Anna Forsby
    Department of Neurochemistry, Svante Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden
    Hum Exp Toxicol 26:333-8. 2007
    ..Our results indicate that it is possible to estimate LOEDs by integrating in vitro toxicity data as surrogates for lowest observed target tissue levels with PBBK models, provided that some knowledge about toxic mechanisms is known...
  50. pmc Methamphetamine toxicity and messengers of death
    Irina N Krasnova
    Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, Baltimore, MD 21224, USA
    Brain Res Rev 60:379-407. 2009
    ....
  51. ncbi Proteomic analysis of rat striatal synaptosomes during acrylamide intoxication at a low dose rate
    David S Barber
    Center for Environmental and Human Toxicology, University of Florida, Building 471, Mowry Road, Gainesville, Florida 32611 0885, USA
    Toxicol Sci 100:156-67. 2007
    ..g., v-ATPase, dopamine transporter, N-ethylmaleimide-sensitive factor) that were progressively and significantly adducted by ACR and might, therefore, be neurotoxicologically relevant targets...
  52. ncbi Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogaster
    Ravikumar Hosamani
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Council of Scientific and Industrial Research, Mysore 570020, India
    Neurotoxicology 30:977-85. 2009
    ..Further, our approach confirms the utility of the Drosophila model in screening putative neuroprotective phytomedicines prior to their use in mammalian models...
  53. ncbi The impact of solvent mixtures on neurobehavioral performance: conclusions from epidemiological data
    Monika Meyer-Baron
    Leibniz Research Center for Working Environment and Human Factors, Dortmund, Germany
    Neurotoxicology 29:349-60. 2008
    ..Paying greater attention to the measurement of exposure and including measures of confounding is advisable for future studies and would enhance the explanatory power of cross-sectional studies and meta-analyses...
  54. pmc Potential developmental neurotoxicity of pesticides used in Europe
    Marina Bjørling-Poulsen
    Department of Environmental Medicine, University of Southern Denmark, Winslowparken 17, 5000 Odense, Denmark
    Environ Health 7:50. 2008
    ..While awaiting more definite evidence, existing uncertainties should be considered in light of the need for precautionary action to protect brain development...
  55. ncbi Acute abnormalities of sensory nerve function associated with oxaliplatin-induced neurotoxicity
    Susanna B Park
    Prince of Wales Medical Research Institute, Barker St, Randwick, Sydney, New South Wales 2031
    J Clin Oncol 27:1243-9. 2009
    ..Because the mechanism of oxaliplatin-induced neurotoxicity remains unclear, the present study investigated the potential of axonal excitability techniques in identifying pathophysiologic mechanisms and early markers of nerve dysfunction...
  56. ncbi Neurotoxic mechanisms of electrophilic type-2 alkenes: soft soft interactions described by quantum mechanical parameters
    Richard M LoPachin
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 E 210th St, Bronx, New York 10467, USA
    Toxicol Sci 98:561-70. 2007
    ..These findings suggest that the neurotoxicity of ACR and its conjugated alkene analogs is related to electrophilic softness and that the thiolate state of cysteine residues is the corresponding adduct target...
  57. ncbi Recreational ecstasy use and the neurotoxic potential of MDMA: current status of the controversy and methodological issues
    Michael Lyvers
    Department of Psychology, Bond University, Gold Coast, Queensland, Australia
    Drug Alcohol Rev 25:269-76. 2006
    ....
  58. ncbi The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity
    Terrence J Monks
    Center for Cellular and Molecular Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712 1074, USA
    Ther Drug Monit 26:132-6. 2004
    ..The data are consistent with the view that thioether metabolites of alpha-MeDA and N-methyl-alpha-MeDA contribute to the neurotoxicity of the parent amphetamines...
  59. ncbi Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity
    Timothy J Shafer
    Neurophysiological Toxicology Branch, Neurotoxicology Division, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 196:303-18. 2004
    ..However, at the present time, the data available neither support nor refute conclusively the hypothesis that effects on VSCC are important to the acute neurotoxicity of pyrethroids...
  60. ncbi Neonatal exposure to neurotoxic pesticides increases adult susceptibility: a review of current findings
    P Eriksson
    Department of Environmental Toxicology, Uppsala University, Sweden
    Neurotoxicology 21:37-47. 2000
    ..Our studies indicate that neonatal exposure to pesticides--even in low doses--can potentiate and/or modify the reaction to adult exposure to xenobiotics, and thereby accelerate dysfunctional processes...
  61. ncbi Evidence against an essential role of endogenous brain dopamine in methamphetamine-induced dopaminergic neurotoxicity
    J Yuan
    Departments of Neurology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Neurochem 77:1338-47. 2001
    ..Collectively, these findings bring into question the view that endogenous DA plays an essential role in METH-induced DA neurotoxicity...
  62. ncbi Dopamine-induced behavioral changes and oxidative stress in methamphetamine-induced neurotoxicity
    Taizo Kita
    Laboratory of Pharmacology, Kyushu Nutrition Welfare University Graduate School of Food and Nutrition, Kitakyushu, Fukuoka 803 8511, Japan
    Int Rev Neurobiol 88:43-64. 2009
    ..Thus, we propose that acute behavioral observation of subjects immediately following methamphetamine administration may provide insight into the long-lasting toxicity to dopaminergic neurons...
  63. ncbi Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia
    Xiao Dong Pan
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian 350001, People s Republic of China
    Biochem Pharmacol 76:362-72. 2008
    ..Therefore, it is potentially a highly effective therapeutic agent in treating neuroninflammatory diseases...
  64. doi Oxaliplatin-related neurotoxicity: interest of calcium-magnesium infusion and no impact on its efficacy
    Laurence Gamelin
    J Clin Oncol 26:1188-9; author reply 1189-90. 2008
  65. ncbi Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51
    Hari Shanker Sharma
    Neurochemistry Laboratory, Division of Neurotoxicology, National Centre for Toxicological Research FDA, Jefferson, AR, USA
    Curr Pharm Des 13:1903-23. 2007
    ..The possible mechanisms and functional significance of these findings are discussed...
  66. pmc Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage
    Mark W Neff
    Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:11725-30. 2004
    ....
  67. pmc Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 77:404-11. 2008
    ..Our results reinforce the conclusion that low dose exposure to different OPs can have quite different neurotoxic effects, obviously unconnected to their shared property as cholinesterase inhibitors...
  68. ncbi Cisplatin-induced DNA-platination in experimental dorsal root ganglia neuronopathy
    C Meijer
    Department of Medical Oncology, University Hospital Groningen, The Netherlands
    Neurotoxicology 20:883-7. 1999
    ..This finding further supports the hypothesis that CDDP is neurotoxic because it directly damages the DRG neurons...
  69. pmc Developmental diazinon neurotoxicity in rats: later effects on emotional response
    Cindy S Roegge
    WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA
    Brain Res Bull 75:166-72. 2008
    ..The effects show not only some similarities to those of chlorpyrifos but also some differences, in keeping with neurochemical findings comparing the two agents...
  70. ncbi Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injury
    Matthew W Warren
    University of Florida Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Life Sci 78:301-9. 2005
    ..Use of calpain and caspase proteolytic inhibitors may be useful in preventing methamphetamine-induced neurotoxicity...
  71. pmc Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 75:640-7. 2008
    ..The effects on 5HT circuits expand the scope of behavioral endpoints that need to be considered in evaluating the developmental neurotoxicity of organophosphates...
  72. ncbi Gadolinium encephalopathy due to accidental intrathecal administration of gadopentetate dimeglumine
    Sönke Arlt
    J Neurol 254:810-2. 2007
  73. ncbi Evaluation of reliability of traditional and computerized neurobehavioral tests
    Joon Sakong
    Department of Preventive Medicine and Public Health, College of Medicine, Yeungnam University, 317 1 Daemyung Dong, Nam Gu, Daegu 705 717, Republic of Korea
    Neurotoxicology 28:235-9. 2007
    ....
  74. ncbi Manganese neurotoxicity: connecting the dots along the continuum of dysfunction
    Christopher J Martin
    Institute of Occupational and Environmental Health, Department of Community Medicine, School of Medicine, West Virginia University, P O Box 9190, 3801 Health Sciences Center South, Morgantown, WV 26506 9190, United States
    Neurotoxicology 27:347-9. 2006
    ..In this decade, it has been proposed that manganese exposure may play a role in the development of IPD itself. Investigating the relationship between these three manifestations should be a priority for future research...
  75. ncbi Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Toxicol Appl Pharmacol 198:132-51. 2004
    ..Novel in vitro and in vivo exposure models are being developed to uncover heretofore unsuspected mechanisms and targets for developmental neurotoxicants...
  76. ncbi High signal intensity on magnetic resonance imaging as a predictor of neurobehavioral performance of workers exposed to manganese
    Yong Chul Shin
    Department of Occupational Health and Safety, Inje University, Gimhae, Korea
    Neurotoxicology 28:257-62. 2007
    ....
  77. ncbi Ecstasy/MDMA and cannabis: the complexities of their interactive neuropsychobiological effects
    A C Parrott
    University of Wales, Swansea SA2 8PP, UK
    J Psychopharmacol 18:572-5. 2004
  78. ncbi Effects of permethrin given before mating on the behavior of F1-generation in mice
    Amina T Farag
    Department of Pesticide Chemistry and Toxicology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
    Neurotoxicology 27:421-8. 2006
    ..8 and 19.6 mg/kg/d can induce a significant risk to the offspring following treatment of F0-mice before mating. The NOEL obtained in this study for the effects of permethrin on the development of the F1-progeny is 4.9 mg/kg/d...
  79. ncbi Biochemical markers of neurotoxicity in wildlife and human populations: considerations for method development
    Christopher J Stamler
    School of Dietetics and Human Nutrition, Quebec, Canada
    J Toxicol Environ Health A 68:1413-29. 2005
    ..In conclusion, these neurochemical biomarkers can efficiently be measured in large human and wildlife neurotoxicity studies, provided proper storage conditions are maintained...
  80. ncbi A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response
    A Richard Green
    Neuropharmacology Research Group, School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK
    Eur J Pharmacol 500:3-13. 2004
    ..These results suggest that any MDMA-induced hyperthermic response will be enhanced in hot, crowded dance club conditions and that ingesting the drug in such conditions increases the possibility of subsequent cerebral neurotoxic effect...
  81. ncbi Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicology 25:631-40. 2004
    ....
  82. ncbi Electrophysiological evidence of serotonergic impairment in long-term MDMA ("ecstasy") users
    R J Croft
    Department of Cognitive Neuroscience and Behavior, Imperial College, School of Medicine, London, UK
    Am J Psychiatry 158:1687-92. 2001
    ..The results are thus consistent with the thesis that MDMA consumption causes 5-HT impairment in humans...
  83. ncbi The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity
    Beatriz Goni-Allo
    Department of Pharmacology, School of Medicine, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
    Psychopharmacology (Berl) 197:263-78. 2008
    ..A close relationship appears to exist between 3,4-methylenedioxymethamphetamine (MDMA)-induced changes in core body temperature and long-term serotonin (5-HT) loss...
  84. ncbi Serotonergic neurotoxicity of 3,4-(+/-)-methylenedioxyamphetamine and 3,4-(+/-)-methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase
    F Bai
    Center for Cellular and Molecular Toxicology, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712-1074, USA
    Chem Res Toxicol 14:863-70. 2001
    ..The data indicate that thioether metabolites of MDA and MDMA contribute to the serotonergic neurotoxicity observed following peripheral administration of these drugs...
  85. ncbi Long-term functional neurotoxicity of paraoxon and chlorpyrifos: behavioural and pharmacological evidence
    Fernando Sanchez-Santed
    Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almeria, La Canada, 04120 Almeria, Spain
    Neurotoxicol Teratol 26:305-17. 2004
    ....
  86. ncbi Age dependence of organophosphate and carbamate neurotoxicity in the postnatal rat: extrapolation to the human
    Charles A Vidair
    Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA 94612, USA
    Toxicol Appl Pharmacol 196:287-302. 2004
    ..For the organophosphates, the greater sensitivity of postnatal rats, and, by analogy, that expected for human neonates, is correlated with generally lower levels of the enzymes involved in organophosphate deactivation...
  87. ncbi The applicability of WHO-NCTB in Korea
    S K Kang
    Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Inchon, The Republic of Korea
    Neurotoxicology 21:697-701. 2000
    ..It was difficult to apply the WHO-NCTB to workers educated less than 12 years...
  88. ncbi Biochemical mechanisms of cyclosporine neurotoxicity
    Natalie J Serkova
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Mol Interv 4:97-107. 2004
    ..The marked and unparallel potential of magnetic resonance spectroscopy (MRS) as a novel quantitative approach to evaluate metabolic drug toxicity is described...
  89. ncbi Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 84:521-40. 2010
    ..Whether such perturbations will lead to PD-like neuropathological manifestations remains to be elucidated...
  90. pmc Chronic neuropsychological sequelae of cholinesterase inhibitors in the absence of structural brain damage: two cases of acute poisoning
    Lola Roldán-Tapi
    Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almeria, Almeria, Spain
    Environ Health Perspect 113:762-6. 2005
    ....
  91. ncbi Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, DHHS NIH NIDA, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Neurotox Res 11:183-202. 2007
    ..Better understanding of the cellular and molecular mechanisms involved in their toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of amphetamine use disorders in humans...
  92. ncbi Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity
    A C Parrott
    Department of Psychology, University of East London, E15 4LZ, London, UK
    Pharmacol Biochem Behav 71:837-44. 2002
    ..Functional deficits may remain long after drug use has ceased and are consistent with serotonergic axonal loss in higher brain regions...
  93. ncbi Neurotoxic effects of insecticides--current and future research: a review
    F He
    Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing
    Neurotoxicology 21:829-35. 2000
    ..Based on the current issues of insecticide neurotoxicity, future research needs are recommended...
  94. ncbi In vitro assessment of the neurotoxic and neuroprotective effects of N-acetyl-L-cysteine (NAC) on the rat sciatic nerve fibers
    Magdalini Moschou
    Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University, Thessaloniki 54124, Hellas, Greece
    Toxicol In Vitro 22:267-74. 2008
    ..The observed neuroprotective-neurotoxic properties of NAC require careful reconsideration of its use in either in vitro studies or in vivo pharmaceutical applications...
  95. ncbi Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro
    A G Ludolph
    Department of Child and Adolescent Psychiatry, University of Ulm, Ulm, Germany
    J Neural Transm 113:1927-34. 2006
    ..The neurotoxic effects of MPP(+) could be significantly reduced by co-application of MPH, an effect that is most likely explained by MPH blocking the DAT...
  96. ncbi Early pubertal female rats are more resistant than males to 6-hydroxydopamine neurotoxicity and behavioural deficits: a possible role for trophic factors
    I S Pienaar
    Division of Medical Physiology, University of Stellenbosch, Western Cape, South Africa
    Restor Neurol Neurosci 25:513-26. 2007
    ..The present study focused on possible gender differences in vulnerability to 6-OHDA during the early pubertal period when the effects exerted by gonadal steroid hormones are unpronounced...
  97. pmc Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity
    Amina S Woods
    NIH NIDA IRP, Baltimore, Maryland 21224, USA
    J Proteome Res 5:1017-23. 2006
    ..Furthermore, they suggest that synthetic peptides that bind DYNp, thus preventing their interaction with NMDAR, may be novel therapeutic agents for the treatment of spinal cord injury...
  98. ncbi Pyridoxine may protect the cerebellar granular cells against glutamate-induced toxicity
    Mehmet Emin Buyukokuroglu
    Department of Pharmacology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey
    Int J Vitam Nutr Res 77:336-40. 2007
    ..Neuroprotective effect of pyridoxine, at least in part, may result from its anti-glutamatergic activity. Pyridoxine merits further investigation as a therapeutic option in hypoxic-ischemic brain injury...
  99. pmc 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings
    Michael H Baumann
    Clinical Psychopharmacology Section, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 189:407-24. 2007
    ..g., depletion of forebrain 5-HT) that have been interpreted as neurotoxicity. Whether such 5-HT deficits reflect neuronal damage is a matter of ongoing debate...
  100. ncbi Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine
    Zbigniew K Binienda
    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Neurosci Lett 410:62-5. 2006
    ....
  101. ncbi Subchronic exposure to low-doses of the nerve agent VX: physiological, behavioral, histopathological and neurochemical studies
    Eugenia Bloch-Shilderman
    Department of Pharmacology, Israel Institute for Biological Research, P O Box 19, Ness Ziona 74100, Israel
    Toxicol Appl Pharmacol 231:17-23. 2008
    ..Further research should be addressed towards better understanding of its potential health ramifications and in search of optimal countermeasures...

Research Grants68

  1. COMPUTERIZED TOOL TO SCREEN WORKERS FOR NEUROTOXICITY
    Richard Letz; Fiscal Year: 1993
    ..The system could be adapted to allow its effective use in other countries and in populations potentially most susceptible to effects of neurotoxic exposure such as the elderly and children...
  2. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  3. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  4. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  5. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  6. Developmental Neurotoxicity of Phthalate Esters
    Bernard Weiss; Fiscal Year: 2008
    ..The proposed research will examine this question in rats, and translate its implications into human relevance. [unreadable] [unreadable] [unreadable]..
  7. Neurotoxic Interactions of Different Forms of Mercury
    Bernard Weiss; Fiscal Year: 2007
    ..The acquisition of these data offers a firm foundation for determining the risks to neurobehavioral development of concurrent exposures to both mercury species. ..
  8. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2005
    ..abstract_text> ..
  9. Interdisciplinary Training: Neurodevelopmental Toxicology(RMI)
    David Bellinger; Fiscal Year: 2008
    ..Members of the faculty currently conduct a wealth of multidisciplinary research, which will provide trainees with ready opportunities to apply their training in ongoing research projects. [unreadable] [unreadable]..
  10. Effects of perinatal endocrine disrupters in children
    Philippe Grandjean; Fiscal Year: 2004
    ..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
  11. FREE RADICALS IN MENTAL HEALTH & NEUROBIOLOGY
    Stephen Bondy; Fiscal Year: 2005
    ..The long-term support of this series of annual meetings will permit better planning for meeting organizers, attendees, students, and publishers. ..
  12. Adolescent Exposure to Psychostimulants: Role of nNOS
    Yossef Itzhak; Fiscal Year: 2008
    ..Results of these studies would provide new information on mechanisms that underlie the development of hypersensitivity to these drugs from adolescence through adulthood. ..
  13. Substituted Amphetamines: NO-Dependent Mechanisms
    Yossef Itzhak; Fiscal Year: 2005
    ....
  14. ALUMINUM/IRON INTERACTIONS IN NEURODEGENERATIVE DISEASE
    Stephen Bondy; Fiscal Year: 2005
    ..Together, these five objectives delineate a research strategy that will allow resolution of the seemingly contradictory evidence relating aluminum to neurological degeneration. ..
  15. Neurodegenration and Mitochnodrial Dysfunction in Aging
    Stephen Bondy; Fiscal Year: 2008
    ..This is also likely to be relevant to slowing the onset of, and reducing the incidence of, several neurodegenerative diseases where age is a major co-factor. [unreadable] [unreadable]..
  16. EFFECTIVENESS OF COMPUTER-BASED TRAINING: CTRAIN
    WYNDHAM ANGER; Fiscal Year: 2003
    ..In addition, feedback will be elicited from content experts to evaluate the potential for adoption of the computer-based training program and the "screenbuilder" environment. ..
  17. Web-Delivered PC-Based Low Literacy HAZMAT Training
    WYNDHAM ANGER; Fiscal Year: 2004
    ..s. ..
  18. Reconsolidation and extinction processes in the treatment of drug addiction
    Yossef Itzhak; Fiscal Year: 2010
    ..abstract_text> ..
  19. Effectiveness of computer-based safety training in vine*
    W Anger; Fiscal Year: 2006
    ..abstract_text> ..
  20. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
  21. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
  22. Methamphetamine Neurotoxicity in Nonhuman Primates
    George Ricaurte; Fiscal Year: 2006
    ....
  23. Anticholinesterase Neurotoxicity is Mediated by Oxidative Injury
    Dejan Milatovic; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Neurodevelopmental Apoptosis
    Nuri Farber; Fiscal Year: 2008
    ..abstract_text> ..
  25. MDMA Neurotoxicity in Nonhuman Primates
    George Ricaurte; Fiscal Year: 2005
    ..abstract_text> ..
  26. MDMA Neurotoxicity in Humans: Occurence & Consequences
    George Ricaurte; Fiscal Year: 2006
    ....
  27. NEUROTOXIC SUPERFUND CHEMICALS AND BIOMAKERS
    Peter Spencer; Fiscal Year: 2007
    ..abstract_text> ..
  28. ADHD Treatment & Amphetamine Neurotoxicity
    George Ricaurte; Fiscal Year: 2007
    ....
  29. SAFETY ASSESSMENT OF FENFLURAMINE/PHENTERMINE
    George Ricaurte; Fiscal Year: 2001
    ....
  30. Insecticide Action at the Local Anesthetic Receptor
    David M Soderlund; Fiscal Year: 2011
    ..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
  31. GENE EXPRESSION AND METHAMPHETAMINE NEUROTOXICITY
    George Ricaurte; Fiscal Year: 2002
    ..abstract_text> ..
  32. NEUROPROTECTION AGAINST RETINAL ISCHEMIA
    John Olney; Fiscal Year: 2001
    ..These studies will be conducted studies using Muller cell cultures to test this hypothesis. ..
  33. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
  34. Glucocorticoids and Apoptosis of Cerebellar Neural Progenitor Cells
    Nuri Farber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. DEVELOPMENTAL BRAIN DAMAGE BY DRUGS OF ABUSE
    John W Olney; Fiscal Year: 2010
    ..abstract_text> ..
  36. ACUTE BRAIN INJURY, MECHANISMS AND PROTECTION
    John Olney; Fiscal Year: 2001
    ..The long term goals are to clarify the underlying mechanisms and develop improved methods of treating human pediatric acute brain injury conditions. ..
  37. SERT polymorphisms and human cortical 5-HT2A receptors
    Ronald Cowan; Fiscal Year: 2007
    ..Because the rate of depression is greater in females than males, and because regulation of the 5-HT2A receptor is influenced by estrogen, we have chosen to study the effects of having SS or L-A L-A genotype in female subjects. ..
  38. Occupational exposure and the developmental-basis of AD
    Nasser Zawia; Fiscal Year: 2008
    ..We further would like to examine the mechanisms associated with sensitization of animals to disease by early life exposure and how such processes respond in the event of re-exposure during adulthood. ..
  39. Long-term Outcome: Transplant for Alcohol Liver Disease
    Andrea F DiMartini; Fiscal Year: 2010
    ..We also expect to use these data to develop treatment intervention studies for the future. ..
  40. COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER
    Thomas McGlashan; Fiscal Year: 2008
    ....
  41. Ethanol and cholesterol homeostasis in the brain
    Marina Guizzetti; Fiscal Year: 2006
    ..abstract_text> ..
  42. Development of NET-Selective Piperidine-Based PET Ligand
    Anna Liisa Brownell; Fiscal Year: 2006
    ..4. Promising PET imaging agents will be studied in cell toxicity and animal models during the second year. ..
  43. High-Field Functional MRI of Human Euphoria
    Ronald Cowan; Fiscal Year: 2003
    ..Eventually, we believe that a better understanding of the brain structures that allow us to get high, and become addicted, will lead to improved awareness and treatment for substance abuse. ..
  44. Neurocognitive Prerequisites for Preventing Drug Abuse
    Diana Fishbein; Fiscal Year: 2003
    ..This study will provide valuable insights for developing preventive interventions, individualized according to underlying pathology, for adolescents who tend to be refractory to standard treatments. ..
  45. ALCOHOL AND STRESS IN ADOLESCENCE
    Linda Spear; Fiscal Year: 2003
    ..The results of this basic research should provide an essential initial base of data regarding ethanol reinforcement and stress during adolescence as well as potential long-lasting consequences of such exposure. ..
  46. EARLY DETECTION AND INTERVENTION IN PSYCHOSIS
    Thomas McGlashan; Fiscal Year: 2003
    ..abstract_text> ..
  47. SPECIES DIFFERENCE IN THE BIOTRANSFORMATION OF AFLATOXIN
    David Eaton; Fiscal Year: 2003
    ..abstract_text> ..
  48. REGULATION OF BRAIN PEPTIDE BIOSYNTHESIS
    Michael Bannon; Fiscal Year: 2003
    ....
  49. INTERACTION OF LEAD WITH ZINC FINGER PROTEINS
    Nasser Zawia; Fiscal Year: 2002
    ..Understanding the mechanism of lead neurotoxicity with the models and experiments hitherto proposed will shed more light on metal toxicity and broaden our knowledge of the impact of heavy metals in the environment on our health. ..
  50. DISEASE PROGRESSION AND OXIDATIVE STRESS IN ALS
    Zuoshang Xu; Fiscal Year: 2002
    ..Further, we will test whether and how anti-oxidant treatment changes the course of disease progression. ..
  51. Neurotoxicology of dietary iron/manganese interactions
    Keith Erikson; Fiscal Year: 2005
    ..If successful, these studies will lay the foundation for the development of a pharmacological therapy aimed at the prevention of manganese-accumulation in vulnerable populations. ..
  52. In-Vivo Spectroscopy/Imaging System PharmaScan 47/16
    Natalie Serkova; Fiscal Year: 2005
    ..This is a much needed instrumentation and will provide an important regional facility for in vivo research in Colorado and the surrounding Rocky Mountain region. ..
  53. Developmental Pyrethroid Exposure and Parkinsons Disease
    Jason Richardson; Fiscal Year: 2005
    ....
  54. CASPASES, MITOCHONDRIAL FUNCTION AND PARKINSON'S DISEASE
    Anumantha Kanthasamy; Fiscal Year: 2006
    ..abstract_text> ..
  55. SIGNAL TRANSDUCTION MECHANISMS AND LEAD TOXICITY
    Joseph Bressler; Fiscal Year: 2001
    ..Ultimately, a protein that is phosphorylated in rats with elevated levels of Pb2+ may provide a biomarker to monitor Pb2+. ..
  56. PATHWAYS TO ROS INDUCED CELL DEATH
    TERRENCE MONKS; Fiscal Year: 2006
    ..Basic knowledge of the mechanisms by which ROS induce cell death may yield strategies for clinical interventions in pathologies in which ROS play a prominent role ..
  57. 'Training in Endocrinology and Neurobiology of Aging'
    Caleb Finch; Fiscal Year: 2007
    ..Opportunities for human studies on aging, including ethnic differences in aging processes, are provided through the Alzheimer Disease Research Center and the Diabetes Research Center. ..
  58. Neurotoxicity of NMDA Receptor Antagonists
    Frank Sharp; Fiscal Year: 2005
    ..abstract_text> ..
  59. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  60. Neuronal Injury and Blood Genomics
    Frank Sharp; Fiscal Year: 2005
    ..abstract_text> ..
  61. VOLTAGE SENSITIVE CALCIUM CHANNELS IN BRAIN INJURY
    Robert Berman; Fiscal Year: 2002
    ....
  62. MARKERS OF CNS INJURY
    Frank Sharp; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  63. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  64. Behavioral Health Effects of September 11th, 2001
    Charles DiMaggio; Fiscal Year: 2006
    ..abstract_text> ..
  65. PCB Congener/Metabolite Patterns in Akwesasne Mohawks
    Anthony DeCaprio; Fiscal Year: 2006
    ..abstract_text> ..