Genomes and Genes
Summary: Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.
Publications253 found, 100 shown here
- Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicityBo Jiang
School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, China
Neurol Res 30:639-44. 2008..DA turnover in MPTP mice was reversed in the nigrostriatal pathway. In conclusion, data obtained in the above study suggested that catalpol exerted neuroprotective action in vitro and in vivo PD model...
- Oxaliplatin-induced neurotoxicity: changes in axonal excitability precede development of neuropathySusanna B Park
Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, NSW 2031, Australia
Brain 132:2712-23. 2009..05) than those left with mild or moderate neurotoxicity, suggesting that assessment of sensory excitability parameters may provide a sensitive biomarker of severity for oxaliplatin-induced neurotoxicity...
- Developmental neurotoxicity of industrial chemicalsP Grandjean
Institute of Public Health, University of Southern Denmark, Odense, Denmark
Lancet 368:2167-78. 2006..New, precautionary approaches that recognise the unique vulnerability of the developing brain are needed for testing and control of chemicals...
- Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumptionKathryn R Mahaffey
Department of Occupational and Environmental Health, George Washington University School of Public Health, Washington DC, USA
Nutr Rev 69:493-508. 2011..A framework for providing dietary advice for women of childbearing age on how to maximize the dietary intake of n-3 PUFAs while minimizing MeHg exposures is suggested...
- Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessmentDavid M Soderlund
Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
Toxicology 171:3-59. 2002....
- Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needsTimothy J Shafer
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Health Perspect 113:123-36. 2005..These studies should employ state-of-the-science methods to promote a greater understanding of the mode of action of pyrethroids in the developing nervous system...
- Poisoning due to pyrethroidsSally M Bradberry
National Poisons Information Service Birmingham Centre, City Hospital, UK
Toxicol Rev 24:93-106. 2005..Management is supportive. As paraesthesiae usually resolve in 12-24 hours, specific treatment is not generally required, although topical application of dl-alpha tocopherol acetate (vitamin E) may reduce their severity...
- Safety analysis of FOLFOX4 treatment in colorectal cancer patients: a comparison between two Asian studies and four Western studiesKenichi Sugihara
Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan
Clin Colorectal Cancer 11:127-37. 2012..As part of the Japanese submission for the adjuvant indication, the safety profile of FOLFOX4 regimen was compared in Asian and Western patients...
- Oxaliplatin-related neurotoxicity: how and why?Lara Maria Pasetto
Medical Oncology Division, Azienda Ospedale Universita, Via Gattamelata 64, Padova, Italy
Crit Rev Oncol Hematol 59:159-68. 2006..The aim of this review is to analyse the mechanism underlying induction of neurotoxicity and the possible treatments to prevent and to treat it...
- Neurobehavioral toxicology of pyrethroid insecticides in adult animals: a critical reviewM J Wolansky
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 30:55-78. 2008..For risk assessment purposes, a strategy that takes into account data from an array of neurobehavioral endpoints is needed to capture the heterogeneity of pyrethroid-induced adverse effects and accurately inform policy decisions...
- Acrylamide: review of toxicity data and dose-response analyses for cancer and noncancer effectsA Shipp
ENVIRON International Corporation, 602 East Georgia Street, Ruston, LA 07290, USA
Crit Rev Toxicol 36:481-608. 2006..However, it should be noted that although this review was intended to be comprehensive, it is not exhaustive, as new data are being published continuously...
- Strategies and tools for preventing neurotoxicity: to test, to predict and how to do itJordi Llorens
Department of Physiological Sciences II, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain
Neurotoxicology 33:796-804. 2012....
- Practical considerations on the design, execution and analysis of developmental neurotoxicity studies to be published in Neurotoxicology and TeratologyJacques Maurissen
The Dow Chemical Company, Toxicology and Environmental Research and Consulting, 1803 Bldg, Midland, MI 48674, USA
Neurotoxicol Teratol 32:121-3. 2010..g., litter), addressing the results of all analyses (e.g., "negative" results are important). Data interpretation should be evidence-based and not exceed the limits of the findings...
- Cerebrovascular damage in young rabbits after intravenous administration of Shiga toxin 2M Mizuguchi
Department of Pediatrics, Jichi Medical School, Tochigi, Japan
Acta Neuropathol 102:306-12. 2001..Given our results, we conclude that the cerebral blood vessels of immature brains are more vulnerable to Stx2 than those of adults in the rabbit...
- Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticidesCharles B Breckenridge
Syngenta Crop Protection Inc, P O Box 18300, Greensboro, NC 27419 8300, USA
Neurotoxicology 30:S17-31. 2009..Fenpropathrin and esfenvalerate occupy an intermediate position between these two groups...
- A reassessment of the neurotoxicity of pyrethroid insecticidesDavid E Ray
School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
Pharmacol Ther 111:174-93. 2006..The evidence for these is at present equivocal, but all 3 carry important implications for human health...
- Intravenous calcium and magnesium for oxaliplatin-induced sensory neurotoxicity in adjuvant colon cancer: NCCTG N04C7Axel Grothey
Mayo Clinic Rochester, Rochester, MN 55905, USA
J Clin Oncol 29:421-7. 2011..In a nonrandomized, retrospective study, intravenous (IV) calcium/magnesium (Ca/Mg) was associated with reduced oxaliplatin-induced sNT...
- Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanismsJohnalyn Lyles
Molecular Neuropsychiatry Branch, National Institutes of Health National Institute on Drug Abuse Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res Brain Res Rev 42:155-68. 2003..Much remains to be done in order to clarify the molecular and biochemical pathways involved in the long-term neuroplastic changes associated with MDMA abuse...
- Neurotoxicity of pesticides: a brief reviewLucio G Costa
Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
Front Biosci 13:1240-9. 2008..This brief review highlights some of the main neurotoxic pesticides, their effects, and mechanisms of action...
- Neurodevelopmental toxicity risks due to occupational exposure to industrial chemicals during pregnancyJordi Julvez
Department of Environmental Health, Harvard School of Public Health, Landmark Building 3E 110, 401 Park Drive, Boston, MA 02215, USA
Ind Health 47:459-68. 2009..Due to the vulnerability of the brain during early development, a precautionary approach to neurodevelopmental toxicity needs to be applied in occupational health...
- Neuropathy in an artist exposed to organic solvents in paints: a case studyShlomo Moshe
Hashfela Occupational Medicine Unit, Maccabi Medical Services, Yavne, Israel
Arch Environ Health 57:127-9. 2002..The authors were unable to find any similar case report in the literature...
- Analysis and integration of developmental neurotoxicity and ancillary data into risk assessment: a case study of dimethoateJohn M DeSesso
Noblis, Falls Church, Virginia 22042, USA
J Toxicol Environ Health A 72:94-109. 2009....
- Ganglioside GM1 (porcine) ameliorates paclitaxel-induced neuropathy in ratsVilai Chentanez
Peripheral Nerve Research Unit, Department ofAnatomy, Faculty of Medicine, Chulalongkorn University, Bangkok
J Med Assoc Thai 92:50-7. 2009..Monosialic acid ganglioside (GM1) has been shown to protect neurons against injuries and degeneration. However, its efficacy in the treatment of paclitaxel-induced neuropathy has not been verified...
- Organophosphorus ester-induced chronic neurotoxicityMohamed B Abou-Donia
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Arch Environ Health 58:484-97. 2003....
- Assessing the effects of environmental toxicant exposure in developmental epidemiological studies: issues for risk assessmentDeborah C Rice
Environmental Health Unit, Maine Bureau of Health, State House Station 11, Augusta, ME 04333, USA
Neurotoxicology 26:483-9. 2005..Opportunity for discussion among investigators, statisticians, and risk assessors potentially would result in human developmental toxicity studies being maximally useful for public health decisions...
- Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readoutsChristoph van Thriel
Neurobehavioural Toxicology and Chemosensation, IfADo Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
Neurotoxicology 33:911-24. 2012..We envision that future in vitro test systems for developmental neurotoxicity will combine the above approaches with exposure information, and we suggest a strategy for test system development and cell-based risk assessment...
- Nitric oxide in the central nervous system: neuroprotection versus neurotoxicityVittorio Calabrese
Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
Nat Rev Neurosci 8:766-75. 2007..In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic...
- Role of the Nrf2-ARE pathway in acrylamide neurotoxicityLihai Zhang
Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467 2490, United States
Toxicol Lett 205:1-7. 2011..Because a cytoprotective response was not induced in any fraction, nerve terminal vulnerability to ACR cannot be ascribed to the absence of transcription-based defense mechanisms in this neuronal region...
- The ABCB1-1Delta mutation is not responsible for subchronic neurotoxicity seen in dogs of non-collie breeds following macrocyclic lactone treatment for generalized demodicosisStéphane Bissonnette
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, St Hyacinthe, Quebec, Canada
Vet Dermatol 20:60-6. 2009....
- Comparative functional observational battery study of twelve commercial pyrethroid insecticides in male rats following acute oral exposureMyra L Weiner
TOXpertise, LLC, Princeton, NJ 08540, USA
Neurotoxicology 30:S1-16. 2009..Group 2 would include cypermethrin, deltamethrin, esfenvalerate, beta-cyfluthrin and lambda-cyhalothrin. Fenpropathrin exhibited features of both groups...
- Application of silver degeneration stains for neurotoxicity testingR C Switzer
Neuroscience Associates, Knoxville, Tennessee 37922, USA
Toxicol Pathol 28:70-83. 2000..Other newly developed silver methods have been refined to show nondisintegrative degeneration, such as the plaques,and tangles of Alzheimer's disease...
- Amelioration of oxaliplatin neurotoxicity by drugs in humans and experimental animals: a minireview of recent literatureBadreldin H Ali
Department of Pharmacology and Clinical Pharmacy, College of Medicine, Sultan Qaboos University, Sultanate of Oman
Basic Clin Pharmacol Toxicol 106:272-9. 2010..None of these drugs have been proven to be effective in large, controlled, clinical trials...
- Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 ratsJoan Garey
Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72211, United States
Neurotoxicol Teratol 32:220-5. 2010....
- Integration of epidemiology and animal neurotoxicity data for risk assessmentAbby A Li
Exponent Health Sciences, Menlo Park, CA 94025, USA
Neurotoxicology 33:823-32. 2012....
- Use of calcium and magnesium salts to reduce oxaliplatin-related neurotoxicityHoward S Hochster
J Clin Oncol 25:4028-9. 2007
- Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseasesRichard M LoPachin
Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10467 2490, USA
Toxicol Sci 104:235-49. 2008....
- Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickelTheodore A Slotkin
Department of Pharmacology and Cancer Biology Box 3813, Duke University Medical Center, Durham, NC 27710, USA
Toxicol Appl Pharmacol 233:211-9. 2008....
- Interpretation of small effect sizes in occupational and environmental neurotoxicology: individual versus population riskDavid C Bellinger
Children s Hospital Boston, Harvard Medical School, Farley Basement Box 127, 300 Longwood Avenue, Boston, MA 02115, USA
Neurotoxicology 28:245-51. 2007....
- Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: a randomized, double-blind, placebo-controlled trialStefano Cascinu
Department of Medical Oncology, Azienda Ospedaliera Universitaria di Parma, Via Gramsci 14, 43100 Parma, Italy
J Clin Oncol 20:3478-83. 2002..We performed a randomized, double-blind, placebo-controlled trial to assess the efficacy of glutathione (GSH) in the prevention of oxaliplatin-induced neurotoxicity...
- Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancerGregory D Leonard
Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Naval Medical Center, Bethesda, MD 20889 5105, USA
BMC Cancer 5:116. 2005..Oxaliplatin, an agent used in first-line therapy for metastatic colorectal cancer, causes acute and chronic neurotoxicity. This study was performed to carefully assess the incidence, type and duration of oxaliplatin neurotoxicity...
- The use of developmental neurotoxicity data in pesticide risk assessmentsKathleen C Raffaele
Office of Research and Development, U S Environmental Protection Agency, 1200 Pennsylvania Ave, Washington, DC 20460, USA
Neurotoxicol Teratol 32:563-72. 2010....
- Oxaliplatin and axonal Na+ channel function in vivoArun V Krishnan
Institute of Neurological Sciences, Prince of Wales Hospital, Sydney, New South Wales, Australia
Clin Cancer Res 12:4481-4. 2006..The aim of the study was to investigate the pathophysiology of oxaliplatin-induced neurotoxicity using clinical nerve excitability techniques that provide information about axonal ion channel function...
- Quantification and localization of kainic acid-induced neurotoxicity employing a new biomarker of cell death: cleaved microtubule-associated protein-tau (C-tau)F P Zemlan
Department of Psychiatry, College of Medicine, 231 Sabin Avenue, University of Cincinnati, Cincinnati, OH 45267, USA
Neuroscience 121:399-409. 2003..These data suggest that C-tau proteolysis may prove a reliable species independent biomarker of neuronal degeneration regardless of source of injury...
- Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxinsRipon Paul
MIND Institute, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
Neurotoxicology 31:399-402. 2010....
- Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicantsRichard M LoPachin
Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467 2490, USA
Toxicol Sci 94:240-55. 2006..The proposed mechanism of electrophilic neurotoxicants represents a new and exciting experimental framework for mechanistic research in human neuropathological conditions associated with toxicant exposure or disease-based processes...
- Hypothesis-based weight-of-evidence evaluation of the neurodevelopmental effects of chlorpyrifosRobyn L Prueitt
Gradient, Cambridge, Massachusetts 02138, USA
Crit Rev Toxicol 41:822-903. 2011....
- Prevention of oxaliplatin-induced peripheral sensory neuropathy by carbamazepine in patients with advanced colorectal cancerChristian Lersch
II Medical Hospital and Health Center, Technischen Universitat Munchen, Klinikum rechts der Isar, Ismaninger St 22, 81675 Munich, Germany
Clin Colorectal Cancer 2:54-8. 2002..Randomized clinical studies are necessary to confirm the potential benefit of carbamazepine and other sodium channel blockers in preventing and/or overcoming the development of oxaliplatin-induced neurotoxicity...
- Assessing environmental neurotoxicant exposures and child neurobehavior: confounded by confounding?David C Bellinger
Department of Neurology Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
Epidemiology 15:383-4. 2004
- Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicityAnna Forsby
Department of Neurochemistry, Svante Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden
Hum Exp Toxicol 26:333-8. 2007..Our results indicate that it is possible to estimate LOEDs by integrating in vitro toxicity data as surrogates for lowest observed target tissue levels with PBBK models, provided that some knowledge about toxic mechanisms is known...
- Methamphetamine toxicity and messengers of deathIrina N Krasnova
Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA NIH DHHS, Baltimore, MD 21224, USA
Brain Res Rev 60:379-407. 2009....
- Proteomic analysis of rat striatal synaptosomes during acrylamide intoxication at a low dose rateDavid S Barber
Center for Environmental and Human Toxicology, University of Florida, Building 471, Mowry Road, Gainesville, Florida 32611 0885, USA
Toxicol Sci 100:156-67. 2007..g., v-ATPase, dopamine transporter, N-ethylmaleimide-sensitive factor) that were progressively and significantly adducted by ACR and might, therefore, be neurotoxicologically relevant targets...
- Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogasterRavikumar Hosamani
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Council of Scientific and Industrial Research, Mysore 570020, India
Neurotoxicology 30:977-85. 2009..Further, our approach confirms the utility of the Drosophila model in screening putative neuroprotective phytomedicines prior to their use in mammalian models...
- The impact of solvent mixtures on neurobehavioral performance: conclusions from epidemiological dataMonika Meyer-Baron
Leibniz Research Center for Working Environment and Human Factors, Dortmund, Germany
Neurotoxicology 29:349-60. 2008..Paying greater attention to the measurement of exposure and including measures of confounding is advisable for future studies and would enhance the explanatory power of cross-sectional studies and meta-analyses...
- Potential developmental neurotoxicity of pesticides used in EuropeMarina Bjørling-Poulsen
Department of Environmental Medicine, University of Southern Denmark, Winslowparken 17, 5000 Odense, Denmark
Environ Health 7:50. 2008..While awaiting more definite evidence, existing uncertainties should be considered in light of the need for precautionary action to protect brain development...
- Acute abnormalities of sensory nerve function associated with oxaliplatin-induced neurotoxicitySusanna B Park
Prince of Wales Medical Research Institute, Barker St, Randwick, Sydney, New South Wales 2031
J Clin Oncol 27:1243-9. 2009..Because the mechanism of oxaliplatin-induced neurotoxicity remains unclear, the present study investigated the potential of axonal excitability techniques in identifying pathophysiologic mechanisms and early markers of nerve dysfunction...
- Neurotoxic mechanisms of electrophilic type-2 alkenes: soft soft interactions described by quantum mechanical parametersRichard M LoPachin
Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 E 210th St, Bronx, New York 10467, USA
Toxicol Sci 98:561-70. 2007..These findings suggest that the neurotoxicity of ACR and its conjugated alkene analogs is related to electrophilic softness and that the thiolate state of cysteine residues is the corresponding adduct target...
- Recreational ecstasy use and the neurotoxic potential of MDMA: current status of the controversy and methodological issuesMichael Lyvers
Department of Psychology, Bond University, Gold Coast, Queensland, Australia
Drug Alcohol Rev 25:269-76. 2006....
- The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicityTerrence J Monks
Center for Cellular and Molecular Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712 1074, USA
Ther Drug Monit 26:132-6. 2004..The data are consistent with the view that thioether metabolites of alpha-MeDA and N-methyl-alpha-MeDA contribute to the neurotoxicity of the parent amphetamines...
- Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicityTimothy J Shafer
Neurophysiological Toxicology Branch, Neurotoxicology Division, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 196:303-18. 2004..However, at the present time, the data available neither support nor refute conclusively the hypothesis that effects on VSCC are important to the acute neurotoxicity of pyrethroids...
- Neonatal exposure to neurotoxic pesticides increases adult susceptibility: a review of current findingsP Eriksson
Department of Environmental Toxicology, Uppsala University, Sweden
Neurotoxicology 21:37-47. 2000..Our studies indicate that neonatal exposure to pesticides--even in low doses--can potentiate and/or modify the reaction to adult exposure to xenobiotics, and thereby accelerate dysfunctional processes...
- Evidence against an essential role of endogenous brain dopamine in methamphetamine-induced dopaminergic neurotoxicityJ Yuan
Departments of Neurology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurochem 77:1338-47. 2001..Collectively, these findings bring into question the view that endogenous DA plays an essential role in METH-induced DA neurotoxicity...
- Dopamine-induced behavioral changes and oxidative stress in methamphetamine-induced neurotoxicityTaizo Kita
Laboratory of Pharmacology, Kyushu Nutrition Welfare University Graduate School of Food and Nutrition, Kitakyushu, Fukuoka 803 8511, Japan
Int Rev Neurobiol 88:43-64. 2009..Thus, we propose that acute behavioral observation of subjects immediately following methamphetamine administration may provide insight into the long-lasting toxicity to dopaminergic neurons...
- Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microgliaXiao Dong Pan
Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian 350001, People s Republic of China
Biochem Pharmacol 76:362-72. 2008..Therefore, it is potentially a highly effective therapeutic agent in treating neuroninflammatory diseases...
- Oxaliplatin-related neurotoxicity: interest of calcium-magnesium infusion and no impact on its efficacyLaurence Gamelin
J Clin Oncol 26:1188-9; author reply 1189-90. 2008
- Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51Hari Shanker Sharma
Neurochemistry Laboratory, Division of Neurotoxicology, National Centre for Toxicological Research FDA, Jefferson, AR, USA
Curr Pharm Des 13:1903-23. 2007..The possible mechanisms and functional significance of these findings are discussed...
- Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineageMark W Neff
Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 101:11725-30. 2004....
- Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathionOlga A Timofeeva
Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
Brain Res Bull 77:404-11. 2008..Our results reinforce the conclusion that low dose exposure to different OPs can have quite different neurotoxic effects, obviously unconnected to their shared property as cholinesterase inhibitors...
- Cisplatin-induced DNA-platination in experimental dorsal root ganglia neuronopathyC Meijer
Department of Medical Oncology, University Hospital Groningen, The Netherlands
Neurotoxicology 20:883-7. 1999..This finding further supports the hypothesis that CDDP is neurotoxic because it directly damages the DRG neurons...
- Developmental diazinon neurotoxicity in rats: later effects on emotional responseCindy S Roegge
WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA
Brain Res Bull 75:166-72. 2008..The effects show not only some similarities to those of chlorpyrifos but also some differences, in keeping with neurochemical findings comparing the two agents...
- Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injuryMatthew W Warren
University of Florida Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
Life Sci 78:301-9. 2005..Use of calpain and caspase proteolytic inhibitors may be useful in preventing methamphetamine-induced neurotoxicity...
- Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthoodTheodore A Slotkin
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Brain Res Bull 75:640-7. 2008..The effects on 5HT circuits expand the scope of behavioral endpoints that need to be considered in evaluating the developmental neurotoxicity of organophosphates...
- Gadolinium encephalopathy due to accidental intrathecal administration of gadopentetate dimeglumineSönke Arlt
J Neurol 254:810-2. 2007
- Evaluation of reliability of traditional and computerized neurobehavioral testsJoon Sakong
Department of Preventive Medicine and Public Health, College of Medicine, Yeungnam University, 317 1 Daemyung Dong, Nam Gu, Daegu 705 717, Republic of Korea
Neurotoxicology 28:235-9. 2007....
- Manganese neurotoxicity: connecting the dots along the continuum of dysfunctionChristopher J Martin
Institute of Occupational and Environmental Health, Department of Community Medicine, School of Medicine, West Virginia University, P O Box 9190, 3801 Health Sciences Center South, Morgantown, WV 26506 9190, United States
Neurotoxicology 27:347-9. 2006..In this decade, it has been proposed that manganese exposure may play a role in the development of IPD itself. Investigating the relationship between these three manifestations should be a priority for future research...
- Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphatesTheodore A Slotkin
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Toxicol Appl Pharmacol 198:132-51. 2004..Novel in vitro and in vivo exposure models are being developed to uncover heretofore unsuspected mechanisms and targets for developmental neurotoxicants...
- High signal intensity on magnetic resonance imaging as a predictor of neurobehavioral performance of workers exposed to manganeseYong Chul Shin
Department of Occupational Health and Safety, Inje University, Gimhae, Korea
Neurotoxicology 28:257-62. 2007....
- Ecstasy/MDMA and cannabis: the complexities of their interactive neuropsychobiological effectsA C Parrott
University of Wales, Swansea SA2 8PP, UK
J Psychopharmacol 18:572-5. 2004
- Effects of permethrin given before mating on the behavior of F1-generation in miceAmina T Farag
Department of Pesticide Chemistry and Toxicology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt
Neurotoxicology 27:421-8. 2006..8 and 19.6 mg/kg/d can induce a significant risk to the offspring following treatment of F0-mice before mating. The NOEL obtained in this study for the effects of permethrin on the development of the F1-progeny is 4.9 mg/kg/d...
- Biochemical markers of neurotoxicity in wildlife and human populations: considerations for method developmentChristopher J Stamler
School of Dietetics and Human Nutrition, Quebec, Canada
J Toxicol Environ Health A 68:1413-29. 2005..In conclusion, these neurochemical biomarkers can efficiently be measured in large human and wildlife neurotoxicity studies, provided proper storage conditions are maintained...
- A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic responseA Richard Green
Neuropharmacology Research Group, School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK
Eur J Pharmacol 500:3-13. 2004..These results suggest that any MDMA-induced hyperthermic response will be enhanced in hot, crowded dance club conditions and that ingesting the drug in such conditions increases the possibility of subsequent cerebral neurotoxic effect...
- Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspectiveTheodore A Slotkin
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Neurotoxicology 25:631-40. 2004....
- Electrophysiological evidence of serotonergic impairment in long-term MDMA ("ecstasy") usersR J Croft
Department of Cognitive Neuroscience and Behavior, Imperial College, School of Medicine, London, UK
Am J Psychiatry 158:1687-92. 2001..The results are thus consistent with the thesis that MDMA consumption causes 5-HT impairment in humans...
- The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicityBeatriz Goni-Allo
Department of Pharmacology, School of Medicine, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
Psychopharmacology (Berl) 197:263-78. 2008..A close relationship appears to exist between 3,4-methylenedioxymethamphetamine (MDMA)-induced changes in core body temperature and long-term serotonin (5-HT) loss...
- Serotonergic neurotoxicity of 3,4-(+/-)-methylenedioxyamphetamine and 3,4-(+/-)-methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidaseF Bai
Center for Cellular and Molecular Toxicology, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712-1074, USA
Chem Res Toxicol 14:863-70. 2001..The data indicate that thioether metabolites of MDA and MDMA contribute to the serotonergic neurotoxicity observed following peripheral administration of these drugs...
- Long-term functional neurotoxicity of paraoxon and chlorpyrifos: behavioural and pharmacological evidenceFernando Sanchez-Santed
Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almeria, La Canada, 04120 Almeria, Spain
Neurotoxicol Teratol 26:305-17. 2004....
- Age dependence of organophosphate and carbamate neurotoxicity in the postnatal rat: extrapolation to the humanCharles A Vidair
Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA 94612, USA
Toxicol Appl Pharmacol 196:287-302. 2004..For the organophosphates, the greater sensitivity of postnatal rats, and, by analogy, that expected for human neonates, is correlated with generally lower levels of the enzymes involved in organophosphate deactivation...
- The applicability of WHO-NCTB in KoreaS K Kang
Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Inchon, The Republic of Korea
Neurotoxicology 21:697-701. 2000..It was difficult to apply the WHO-NCTB to workers educated less than 12 years...
- Biochemical mechanisms of cyclosporine neurotoxicityNatalie J Serkova
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Mol Interv 4:97-107. 2004..The marked and unparallel potential of magnetic resonance spectroscopy (MRS) as a novel quantitative approach to evaluate metabolic drug toxicity is described...
- Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumesKrishnan Sriram
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Arch Toxicol 84:521-40. 2010..Whether such perturbations will lead to PD-like neuropathological manifestations remains to be elucidated...
- Chronic neuropsychological sequelae of cholinesterase inhibitors in the absence of structural brain damage: two cases of acute poisoningLola Roldán-Tapi
Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almeria, Almeria, Spain
Environ Health Perspect 113:762-6. 2005....
- Neurotoxicity of substituted amphetamines: molecular and cellular mechanismsJean Lud Cadet
Molecular Neuropsychiatry Branch, DHHS NIH NIDA, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Neurotox Res 11:183-202. 2007..Better understanding of the cellular and molecular mechanisms involved in their toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of amphetamine use disorders in humans...
- Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicityA C Parrott
Department of Psychology, University of East London, E15 4LZ, London, UK
Pharmacol Biochem Behav 71:837-44. 2002..Functional deficits may remain long after drug use has ceased and are consistent with serotonergic axonal loss in higher brain regions...
- Neurotoxic effects of insecticides--current and future research: a reviewF He
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing
Neurotoxicology 21:829-35. 2000..Based on the current issues of insecticide neurotoxicity, future research needs are recommended...
- In vitro assessment of the neurotoxic and neuroprotective effects of N-acetyl-L-cysteine (NAC) on the rat sciatic nerve fibersMagdalini Moschou
Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University, Thessaloniki 54124, Hellas, Greece
Toxicol In Vitro 22:267-74. 2008..The observed neuroprotective-neurotoxic properties of NAC require careful reconsideration of its use in either in vitro studies or in vivo pharmaceutical applications...
- Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitroA G Ludolph
Department of Child and Adolescent Psychiatry, University of Ulm, Ulm, Germany
J Neural Transm 113:1927-34. 2006..The neurotoxic effects of MPP(+) could be significantly reduced by co-application of MPH, an effect that is most likely explained by MPH blocking the DAT...
- Early pubertal female rats are more resistant than males to 6-hydroxydopamine neurotoxicity and behavioural deficits: a possible role for trophic factorsI S Pienaar
Division of Medical Physiology, University of Stellenbosch, Western Cape, South Africa
Restor Neurol Neurosci 25:513-26. 2007..The present study focused on possible gender differences in vulnerability to 6-OHDA during the early pubertal period when the effects exerted by gonadal steroid hormones are unpronounced...
- Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicityAmina S Woods
NIH NIDA IRP, Baltimore, Maryland 21224, USA
J Proteome Res 5:1017-23. 2006..Furthermore, they suggest that synthetic peptides that bind DYNp, thus preventing their interaction with NMDAR, may be novel therapeutic agents for the treatment of spinal cord injury...
- Pyridoxine may protect the cerebellar granular cells against glutamate-induced toxicityMehmet Emin Buyukokuroglu
Department of Pharmacology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey
Int J Vitam Nutr Res 77:336-40. 2007..Neuroprotective effect of pyridoxine, at least in part, may result from its anti-glutamatergic activity. Pyridoxine merits further investigation as a therapeutic option in hypoxic-ischemic brain injury...
- 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findingsMichael H Baumann
Clinical Psychopharmacology Section, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 189:407-24. 2007..g., depletion of forebrain 5-HT) that have been interpreted as neurotoxicity. Whether such 5-HT deficits reflect neuronal damage is a matter of ongoing debate...
- Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitineZbigniew K Binienda
Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Neurosci Lett 410:62-5. 2006....
- Subchronic exposure to low-doses of the nerve agent VX: physiological, behavioral, histopathological and neurochemical studiesEugenia Bloch-Shilderman
Department of Pharmacology, Israel Institute for Biological Research, P O Box 19, Ness Ziona 74100, Israel
Toxicol Appl Pharmacol 231:17-23. 2008..Further research should be addressed towards better understanding of its potential health ramifications and in search of optimal countermeasures...
- COMPUTERIZED TOOL TO SCREEN WORKERS FOR NEUROTOXICITYRichard Letz; Fiscal Year: 1993..The system could be adapted to allow its effective use in other countries and in populations potentially most susceptible to effects of neurotoxic exposure such as the elderly and children...
- Fetal & Adolescent Nicotine Effects on CNS 5HT SystemsTheodore Slotkin; Fiscal Year: 2003..abstract_text> ..
- DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEMTheodore Slotkin; Fiscal Year: 2003....
- MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITYTheodore Slotkin; Fiscal Year: 2004..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
- MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHYRICHARD LOPACHIN; Fiscal Year: 2009..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
- Developmental Neurotoxicity of Phthalate EstersBernard Weiss; Fiscal Year: 2008..The proposed research will examine this question in rats, and translate its implications into human relevance. [unreadable] [unreadable] [unreadable]..
- Neurotoxic Interactions of Different Forms of MercuryBernard Weiss; Fiscal Year: 2007..The acquisition of these data offers a firm foundation for determining the risks to neurobehavioral development of concurrent exposures to both mercury species. ..
- NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERYDavid Bellinger; Fiscal Year: 2005..abstract_text> ..
- Interdisciplinary Training: Neurodevelopmental Toxicology(RMI)David Bellinger; Fiscal Year: 2008..Members of the faculty currently conduct a wealth of multidisciplinary research, which will provide trainees with ready opportunities to apply their training in ongoing research projects. [unreadable] [unreadable]..
- Effects of perinatal endocrine disrupters in childrenPhilippe Grandjean; Fiscal Year: 2004..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
- FREE RADICALS IN MENTAL HEALTH & NEUROBIOLOGYStephen Bondy; Fiscal Year: 2005..The long-term support of this series of annual meetings will permit better planning for meeting organizers, attendees, students, and publishers. ..
- Adolescent Exposure to Psychostimulants: Role of nNOSYossef Itzhak; Fiscal Year: 2008..Results of these studies would provide new information on mechanisms that underlie the development of hypersensitivity to these drugs from adolescence through adulthood. ..
- Substituted Amphetamines: NO-Dependent MechanismsYossef Itzhak; Fiscal Year: 2005....
- ALUMINUM/IRON INTERACTIONS IN NEURODEGENERATIVE DISEASEStephen Bondy; Fiscal Year: 2005..Together, these five objectives delineate a research strategy that will allow resolution of the seemingly contradictory evidence relating aluminum to neurological degeneration. ..
- Neurodegenration and Mitochnodrial Dysfunction in AgingStephen Bondy; Fiscal Year: 2008..This is also likely to be relevant to slowing the onset of, and reducing the incidence of, several neurodegenerative diseases where age is a major co-factor. [unreadable] [unreadable]..
- EFFECTIVENESS OF COMPUTER-BASED TRAINING: CTRAINWYNDHAM ANGER; Fiscal Year: 2003..In addition, feedback will be elicited from content experts to evaluate the potential for adoption of the computer-based training program and the "screenbuilder" environment. ..
- Web-Delivered PC-Based Low Literacy HAZMAT TrainingWYNDHAM ANGER; Fiscal Year: 2004..s. ..
- Reconsolidation and extinction processes in the treatment of drug addictionYossef Itzhak; Fiscal Year: 2010..abstract_text> ..
- Effectiveness of computer-based safety training in vine*W Anger; Fiscal Year: 2006..abstract_text> ..
- Three-generation Human Study of Reproductive Effects of Marine Food ContaminantsPHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
- Health Effects of Lifetime Exposure to Food ContaminantsPhilippe Grandjean; Fiscal Year: 2009..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
- Methamphetamine Neurotoxicity in Nonhuman PrimatesGeorge Ricaurte; Fiscal Year: 2006....
- Anticholinesterase Neurotoxicity is Mediated by Oxidative InjuryDejan Milatovic; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Neurodevelopmental ApoptosisNuri Farber; Fiscal Year: 2008..abstract_text> ..
- MDMA Neurotoxicity in Nonhuman PrimatesGeorge Ricaurte; Fiscal Year: 2005..abstract_text> ..
- MDMA Neurotoxicity in Humans: Occurence & ConsequencesGeorge Ricaurte; Fiscal Year: 2006....
- NEUROTOXIC SUPERFUND CHEMICALS AND BIOMAKERSPeter Spencer; Fiscal Year: 2007..abstract_text> ..
- ADHD Treatment & Amphetamine NeurotoxicityGeorge Ricaurte; Fiscal Year: 2007....
- SAFETY ASSESSMENT OF FENFLURAMINE/PHENTERMINEGeorge Ricaurte; Fiscal Year: 2001....
- Insecticide Action at the Local Anesthetic ReceptorDavid M Soderlund; Fiscal Year: 2011..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
- GENE EXPRESSION AND METHAMPHETAMINE NEUROTOXICITYGeorge Ricaurte; Fiscal Year: 2002..abstract_text> ..
- NEUROPROTECTION AGAINST RETINAL ISCHEMIAJohn Olney; Fiscal Year: 2001..These studies will be conducted studies using Muller cell cultures to test this hypothesis. ..
- CO POISONING IN THE CONTEXT OF A REPERFUSION INJURYStephen Thom; Fiscal Year: 2003..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
- Glucocorticoids and Apoptosis of Cerebellar Neural Progenitor CellsNuri Farber; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- DEVELOPMENTAL BRAIN DAMAGE BY DRUGS OF ABUSEJohn W Olney; Fiscal Year: 2010..abstract_text> ..
- ACUTE BRAIN INJURY, MECHANISMS AND PROTECTIONJohn Olney; Fiscal Year: 2001..The long term goals are to clarify the underlying mechanisms and develop improved methods of treating human pediatric acute brain injury conditions. ..
- SERT polymorphisms and human cortical 5-HT2A receptorsRonald Cowan; Fiscal Year: 2007..Because the rate of depression is greater in females than males, and because regulation of the 5-HT2A receptor is influenced by estrogen, we have chosen to study the effects of having SS or L-A L-A genotype in female subjects. ..
- Occupational exposure and the developmental-basis of ADNasser Zawia; Fiscal Year: 2008..We further would like to examine the mechanisms associated with sensitization of animals to disease by early life exposure and how such processes respond in the event of re-exposure during adulthood. ..
- Long-term Outcome: Transplant for Alcohol Liver DiseaseAndrea F DiMartini; Fiscal Year: 2010..We also expect to use these data to develop treatment intervention studies for the future. ..
- COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDERThomas McGlashan; Fiscal Year: 2008....
- Ethanol and cholesterol homeostasis in the brainMarina Guizzetti; Fiscal Year: 2006..abstract_text> ..
- Development of NET-Selective Piperidine-Based PET LigandAnna Liisa Brownell; Fiscal Year: 2006..4. Promising PET imaging agents will be studied in cell toxicity and animal models during the second year. ..
- High-Field Functional MRI of Human EuphoriaRonald Cowan; Fiscal Year: 2003..Eventually, we believe that a better understanding of the brain structures that allow us to get high, and become addicted, will lead to improved awareness and treatment for substance abuse. ..
- Neurocognitive Prerequisites for Preventing Drug AbuseDiana Fishbein; Fiscal Year: 2003..This study will provide valuable insights for developing preventive interventions, individualized according to underlying pathology, for adolescents who tend to be refractory to standard treatments. ..
- ALCOHOL AND STRESS IN ADOLESCENCELinda Spear; Fiscal Year: 2003..The results of this basic research should provide an essential initial base of data regarding ethanol reinforcement and stress during adolescence as well as potential long-lasting consequences of such exposure. ..
- EARLY DETECTION AND INTERVENTION IN PSYCHOSISThomas McGlashan; Fiscal Year: 2003..abstract_text> ..
- SPECIES DIFFERENCE IN THE BIOTRANSFORMATION OF AFLATOXINDavid Eaton; Fiscal Year: 2003..abstract_text> ..
- REGULATION OF BRAIN PEPTIDE BIOSYNTHESISMichael Bannon; Fiscal Year: 2003....
- INTERACTION OF LEAD WITH ZINC FINGER PROTEINSNasser Zawia; Fiscal Year: 2002..Understanding the mechanism of lead neurotoxicity with the models and experiments hitherto proposed will shed more light on metal toxicity and broaden our knowledge of the impact of heavy metals in the environment on our health. ..
- DISEASE PROGRESSION AND OXIDATIVE STRESS IN ALSZuoshang Xu; Fiscal Year: 2002..Further, we will test whether and how anti-oxidant treatment changes the course of disease progression. ..
- Neurotoxicology of dietary iron/manganese interactionsKeith Erikson; Fiscal Year: 2005..If successful, these studies will lay the foundation for the development of a pharmacological therapy aimed at the prevention of manganese-accumulation in vulnerable populations. ..
- In-Vivo Spectroscopy/Imaging System PharmaScan 47/16Natalie Serkova; Fiscal Year: 2005..This is a much needed instrumentation and will provide an important regional facility for in vivo research in Colorado and the surrounding Rocky Mountain region. ..
- Developmental Pyrethroid Exposure and Parkinsons DiseaseJason Richardson; Fiscal Year: 2005....
- CASPASES, MITOCHONDRIAL FUNCTION AND PARKINSON'S DISEASEAnumantha Kanthasamy; Fiscal Year: 2006..abstract_text> ..
- SIGNAL TRANSDUCTION MECHANISMS AND LEAD TOXICITYJoseph Bressler; Fiscal Year: 2001..Ultimately, a protein that is phosphorylated in rats with elevated levels of Pb2+ may provide a biomarker to monitor Pb2+. ..
- PATHWAYS TO ROS INDUCED CELL DEATHTERRENCE MONKS; Fiscal Year: 2006..Basic knowledge of the mechanisms by which ROS induce cell death may yield strategies for clinical interventions in pathologies in which ROS play a prominent role ..
- 'Training in Endocrinology and Neurobiology of Aging'Caleb Finch; Fiscal Year: 2007..Opportunities for human studies on aging, including ethnic differences in aging processes, are provided through the Alzheimer Disease Research Center and the Diabetes Research Center. ..
- Neurotoxicity of NMDA Receptor AntagonistsFrank Sharp; Fiscal Year: 2005..abstract_text> ..
- Adolescence: A Sensitive Period for Nicotine AddictionEdward Levin; Fiscal Year: 2008..unreadable] [unreadable]..
- Neuronal Injury and Blood GenomicsFrank Sharp; Fiscal Year: 2005..abstract_text> ..
- VOLTAGE SENSITIVE CALCIUM CHANNELS IN BRAIN INJURYRobert Berman; Fiscal Year: 2002....
- MARKERS OF CNS INJURYFrank Sharp; Fiscal Year: 2006..unreadable] [unreadable]..
- Phase II Trial of Thalidomide in Primary AmyloidosisAngela Dispenzieri; Fiscal Year: 2002..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
- Behavioral Health Effects of September 11th, 2001Charles DiMaggio; Fiscal Year: 2006..abstract_text> ..
- PCB Congener/Metabolite Patterns in Akwesasne MohawksAnthony DeCaprio; Fiscal Year: 2006..abstract_text> ..