diabetic neuropathies

Summary

Summary: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)

Top Publications

  1. ncbi Diabetic autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk 23510, USA
    Diabetes Care 26:1553-79. 2003
  2. pmc Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments
    Solomon Tesfaye
    Diabetes Research Unit, Sheffield Teaching Hospitals, Sheffield, UK
    Diabetes Care 33:2285-93. 2010
  3. ncbi Effect of a multifactorial intervention on mortality in type 2 diabetes
    Peter Gaede
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 358:580-91. 2008
  4. ncbi Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
    Angelika Bierhaus
    Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
    Nat Med 18:926-33. 2012
  5. ncbi Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
  6. ncbi Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation
    J D England
    Neurology 64:199-207. 2005
  7. ncbi Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics
    K Van Acker
    Department of Endocrinology, St Jozef Clinic, Bornem, Belgium
    Diabetes Metab 35:206-13. 2009
  8. pmc Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy
    Mitra Tavakoli
    Division of Cardiovascular Medicine, University of Manchester and Central Manchester Foundation Trust, Manchester, U K
    Diabetes Care 33:1792-7. 2010
  9. ncbi Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy
    Vera Bril
    Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Diabetes Care 25:2048-52. 2002
  10. ncbi Diabetic cardiovascular autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institute, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Circulation 115:387-97. 2007

Detail Information

Publications307 found, 100 shown here

  1. ncbi Diabetic autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk 23510, USA
    Diabetes Care 26:1553-79. 2003
    ..Finally, knowledge of early autonomic dysfunction can encourage patient and physician to improve metabolic control and to use therapies such as ACE inhibitors and beta-blockers, proven to be effective for patients with CAN...
  2. pmc Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments
    Solomon Tesfaye
    Diabetes Research Unit, Sheffield Teaching Hospitals, Sheffield, UK
    Diabetes Care 33:2285-93. 2010
    ....
  3. ncbi Effect of a multifactorial intervention on mortality in type 2 diabetes
    Peter Gaede
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 358:580-91. 2008
    ..We evaluated whether this approach would have an effect on the rates of death from any cause and from cardiovascular causes...
  4. ncbi Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
    Angelika Bierhaus
    Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
    Nat Med 18:926-33. 2012
    ..This previously undescribed concept of metabolically driven hyperalgesia provides a new basis for the design of therapeutic interventions for painful diabetic neuropathy...
  5. ncbi Glucose control and vascular complications in veterans with type 2 diabetes
    William Duckworth
    Phoenix Veterans Affairs Health Care Center, Phoenix, AZ 85012, USA
    N Engl J Med 360:129-39. 2009
    ..The effects of intensive glucose control on cardiovascular events in patients with long-standing type 2 diabetes mellitus remain uncertain...
  6. ncbi Distal symmetric polyneuropathy: a definition for clinical research: report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation
    J D England
    Neurology 64:199-207. 2005
    ..The inclusion of this formalized case definition in clinical and epidemiologic research studies will ensure greater consistency of case selection...
  7. ncbi Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics
    K Van Acker
    Department of Endocrinology, St Jozef Clinic, Bornem, Belgium
    Diabetes Metab 35:206-13. 2009
    ..The association of DPN and DPN-P with other diabetic complications, the impact on quality of life (QoL) and pain management were also investigated...
  8. pmc Corneal confocal microscopy: a novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy
    Mitra Tavakoli
    Division of Cardiovascular Medicine, University of Manchester and Central Manchester Foundation Trust, Manchester, U K
    Diabetes Care 33:1792-7. 2010
    ..The accurate quantification of human diabetic neuropathy is important to define at-risk patients, anticipate deterioration, and assess new therapies...
  9. ncbi Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy
    Vera Bril
    Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Diabetes Care 25:2048-52. 2002
    ....
  10. ncbi Diabetic cardiovascular autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institute, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Circulation 115:387-97. 2007
  11. pmc Evidence-based guideline: Treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation
    V Bril
    University Health Network, University of Toronto, Toronto, Canada
    Neurology 76:1758-65. 2011
    ..To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN)...
  12. pmc Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study
    James W Albers
    Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Diabetes Care 33:1090-6. 2010
    ....
  13. ncbi Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy
    Solomon Tesfaye
    Sheffield Teaching Hospitals, Sheffield, UK
    Diabetes Metab Res Rev 28:8-14. 2012
    ..Management of patients with painful neuropathy must be tailored to individual requirements and will depend on the presence of other co-morbidities. There is limited literature with regard to combination treatment...
  14. pmc Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 33:1578-84. 2010
    ....
  15. pmc Impaired glycemia and diabetic polyneuropathy: the OC IG Survey
    Peter J Dyck
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes Care 35:584-91. 2012
    ....
  16. pmc Altered C-fiber function as an indicator of early peripheral neuropathy in individuals with impaired glucose tolerance
    Alistair Q Green
    The Diabetes Research Centre, Ipswich Hospital National Health Service Trust, Suffolk, UK
    Diabetes Care 33:174-6. 2010
    ....
  17. ncbi Cooling detection thresholds in the assessment of diabetic sensory polyneuropathy: comparison of CASE IV and Medoc instruments
    Lorne H Zinman
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 27:1674-9. 2004
    ..The present study sought to determine the agreement between two common testing devices and to determine whether these are concordant in their association with predictor variables for diabetic sensory polyneuropathy...
  18. ncbi Lifestyle intervention for pre-diabetic neuropathy
    A Gordon Smith
    Department of Neurology, University of Utah School of Medicine, 50 N Medical Drive, SOM 3R152, Salt Lake City, UT 84132, USA
    Diabetes Care 29:1294-9. 2006
    ....
  19. ncbi Diabetic neuropathy: cellular mechanisms as therapeutic targets
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, 48109 0588, USA
    Nat Rev Neurol 7:573-83. 2011
    ..We highlight the pathways to cellular injury, thereby identifying promising therapeutic targets, including mitochondrial function and inflammation...
  20. ncbi Diabetic neuropathies: a statement by the American Diabetes Association
    Andrew J M Boulton
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U K
    Diabetes Care 28:956-62. 2005
  21. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
    ..Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies...
  22. ncbi Increased prevalence of impaired glucose tolerance in patients with painful sensory neuropathy
    J R Singleton
    Division of Neuromuscular Disease, Department of Neurology, University of Utah, Salt Lake City, Utah 84132, USA
    Diabetes Care 24:1448-53. 2001
    ....
  23. ncbi High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 56:2598-608. 2007
    ..This study evaluated neuropathic changes and their amenability to dietary and pharmacological interventions in mice fed a high-fat diet (HFD), a model of pre-diabetes and alimentary obesity...
  24. ncbi A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms
    Ralf Baron
    Sektion Neurologische Schmerzforschung und Therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    Pain 146:34-40. 2009
    ..Patient-Reported Outcomes can be used to obtain a precise sensory characterization of each patient...
  25. ncbi Oxidative stress in the pathogenesis of diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Room 4414, Kresge III, 200 Zina Pitcher Place, Ann Arbor 48109, USA
    Endocr Rev 25:612-28. 2004
    ..We conclude that striving for superior antioxidative therapies remains essential for the prevention of neuropathy in diabetic patients...
  26. ncbi Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life
    B S Galer
    Department of Pain Medicine and Palliative Care, Institute for Education and Research in Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, NY 10003, USA
    Diabetes Res Clin Pract 47:123-8. 2000
    ..Thus, this study found that pain associated with diabetic neuropathy is a significant medical issue that has a substantial impact on the quality of life of many people with this condition...
  27. ncbi Pharmacological characterization of standard analgesics on mechanical allodynia in streptozotocin-induced diabetic rats
    Hiroko Yamamoto
    Pharmacology Research Laboratories, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
    Neuropharmacology 57:403-8. 2009
    ..Their efficacies varied depending on the duration of the diabetic condition, suggesting that temporal changes in pharmacodynamic factors could affect the responsiveness of this model to analgesic agents...
  28. ncbi Vascular risk factors and diabetic neuropathy
    Solomon Tesfaye
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom
    N Engl J Med 352:341-50. 2005
    ..We studied risk factors for the development of distal symmetric neuropathy in 1172 patients with type 1 diabetes mellitus from 31 centers participating in the European Diabetes (EURODIAB) Prospective Complications Study...
  29. ncbi The development and validation of a neuropathy- and foot ulcer-specific quality of life instrument
    Loretta Vileikyte
    Departments of Medicine and Behavioral Science, Manchester Royal Infirmary, Manchester, UK
    Diabetes Care 26:2549-55. 2003
    ....
  30. pmc Detection of diabetic sensorimotor polyneuropathy by corneal confocal microscopy in type 1 diabetes: a concurrent validity study
    Ausma Ahmed
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:821-8. 2012
    ..We aimed to determine the corneal confocal microscopy (CCM) parameter that best identifies diabetic sensorimotor polyneuropathy (DSP) in type 1 diabetes and to describe its performance characteristics...
  31. ncbi Reproducibility of in vivo corneal confocal microscopy as a novel screening test for early diabetic sensorimotor polyneuropathy
    P Hertz
    Division of Endocrinology and Metabolism Division of Neurology, University of Toronto, Toronto, ON, Canada
    Diabet Med 28:1253-60. 2011
    ....
  32. ncbi Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial
    Nigishi Hotta
    Chubu Rosai Hospital, 1 10 6 Komei, Nagoya 455 8530, Japan
    Diabetes Care 29:1538-44. 2006
    ..We sought to evaluate the long-term efficacy and safety of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy...
  33. ncbi Diabetic neuropathies. Classification, clinical features, and pathophysiological basis
    Michael Sinnreich
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Neurologist 11:63-79. 2005
    ..Here we provide a short summary of the history of the classification of diabetic neuropathies and try to describe the most common forms classified according to their presumed pathophysiology...
  34. pmc Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes 58:2376-85. 2009
    ..Dyslipidemia also correlates with the development of neuropathy, even in pre-diabetic patients. This study was designed to explore the contribution of dyslipidemia in neuropathy...
  35. ncbi A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy
    Seward B Rutkove
    Harvard Medical School, and Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, TCC 810, Boston, MA 02215, USA
    JAMA 302:1451-8. 2009
    ..Alpha-lipoic acid appears to be effective as well...
  36. ncbi Association of depression and diabetes complications: a meta-analysis
    M de Groot
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Psychosom Med 63:619-30. 2001
    ..The objective of this study was to examine the strength and consistency of the relationship between depression and diabetes complications in studies of type 1 and type 2 adult patients with diabetes...
  37. pmc Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial
    Peter J Dyck
    Peripheral Neuropathy Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 42:157-64. 2010
    ..Study physician dx from signs and symptoms were excessively variable, often overestimating DSPN. Specific approaches to improving clinical proficiency should be tested...
  38. ncbi The LDIflare: a novel test of C-fiber function demonstrates early neuropathy in type 2 diabetes
    Singhan T M Krishnan
    FRCP, The Ipswich Diabetes Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich, UK
    Diabetes Care 27:2930-5. 2004
    ..The aim of this study was to evaluate a novel method for assessing the axon reflex and to determine its value in detecting neuropathy in type 2 diabetes...
  39. ncbi Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep
    Mugdha Gore
    Avalon Health Solutions, Inc, Philadelphia, Pennsylvania 19102, USA
    J Pain Symptom Manage 30:374-85. 2005
    ..01). Painful DPN is associated with decrements in many aspects of patients' lives: physical and emotional functioning, affective symptoms, and sleep problems. The negative impact is higher in patients with greater pain severity...
  40. ncbi Prevalence of lower-extremity disease in the US adult population >=40 years of age with and without diabetes: 1999-2000 national health and nutrition examination survey
    Edward W Gregg
    Division of Diabetes Translation, Centers for Disease Control and Prevention, Centers for Diseases Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 27:1591-7. 2004
    ..The aim of this study was to examine the prevalence of lower-extremity PAD, PN, and overall LED in the overall U.S. population and among those with and without diagnosed diabetes...
  41. ncbi Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons
    Mohamad Yehia El-Mir
    Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain
    J Mol Neurosci 34:77-87. 2008
    ..We thus propose that metformin, beyond its antihyperglycemic role, can also function as a new therapeutic tool for diabetes-associated neurodegenerative disorders...
  42. ncbi A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy
    T Purves
    Neuroscience Division, School of Biological Sciences, University of Manchester, Manchester, UK
    FASEB J 15:2508-14. 2001
    ..These data implicate MAPKs in the etiology of diabetic neuropathy both via direct effects of glucose and via glucose-induced oxidative stress...
  43. pmc Elevated triglycerides correlate with progression of diabetic neuropathy
    Timothy D Wiggin
    Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Diabetes 58:1634-40. 2009
    ..To evaluate mechanisms underlying diabetic neuropathy progression using indexes of sural nerve morphometry obtained from two identical randomized, placebo-controlled clinical trials...
  44. pmc In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy
    Richard B Messinger
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, VA 22908, USA
    Pain 145:184-95. 2009
    ..This confirms that Ca(V)3.2 T-channels, important signal amplifiers in peripheral sensory neurons, may contribute to the cellular hyperexcitability that ultimately leads to the development of painful PDN...
  45. pmc Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Germany
    Diabetes Care 34:2054-60. 2011
    ..Primary end point was a composite score (Neuropathy Impairment Score [NIS]-Lower Limbs [NIS-LL] and seven neurophysiologic tests). Secondary outcome measures included NIS, NIS-LL, nerve conduction, and quantitative sensory tests (QSTs)...
  46. ncbi Chronic painful peripheral neuropathy in an urban community: a controlled comparison of people with and without diabetes
    C Daousi
    Diabetes and Endocrinology Research Group, University Hospital Aintree, Liverpool, UK
    Diabet Med 21:976-82. 2004
    ..A cross-sectional study has been performed in order to estimate the prevalence, severity, and current treatment of chronic painful peripheral neuropathy (CPPN) in people with diabetes in the community...
  47. pmc Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat
    Shuangsong Hong
    Department of Internal Medicine and Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:29341-50. 2004
    ..These results suggest that both TTX-S and TTX-R sodium channels play important roles and that differential phosphorylation of sodium channels involving both serine/threonine and tyrosine sites contributes to painful diabetic neuropathy...
  48. ncbi Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy
    Keiko Naruse
    Department of Internal Medicine, Aichi Gakuin University, School of Dentistry 2 11 Suemori dori, Chikusa ku, Nagoya, 464 8651, Japan
    Diabetes 54:1823-8. 2005
    ..These findings suggest that transplantation of EPCs from cord blood may be a useful treatment for diabetic neuropathy...
  49. ncbi Treatment of diabetic neuropathy and neuropathic pain: how far have we come?
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:S255-61. 2008
    ....
  50. pmc Hyperlipidemia: a new therapeutic target for diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    J Peripher Nerv Syst 14:257-67. 2009
    ..We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration...
  51. ncbi The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 55:3335-43. 2006
    ..The results support the role for increased aldose reductase activity in functional and structural changes of PDN in type 2 diabetes...
  52. pmc Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology
    Christopher H Gibbons
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 33:2629-34. 2010
    ..To determine the relationships among large, small, and autonomic fiber neurophysiological measures in a cross-sectional study of patients with diabetes...
  53. ncbi Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Med Res Opin 23:147-61. 2007
    ..To examine the efficacy and safety of tramadol/acetaminophen (APAP) for the management of painful diabetic peripheral neuropathy (DPN)...
  54. ncbi Fifteen-day acupuncture treatment relieves diabetic peripheral neuropathy
    YanQing Tong
    The First Affiliated Hospital to Changchun University of Chinese Medicine, Department of Acupuncture, 1478 Gongnong Road, Changchun, Jilin 130021, China
    J Acupunct Meridian Stud 3:95-103. 2010
    ..Our pilot study has, therefore, provided evidence that acupuncture may be clinically useful for the radical treatment of diabetic peripheral neuropathy...
  55. pmc p38 mediates mechanical allodynia in a mouse model of type 2 diabetes
    Hsinlin T Cheng
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Mol Pain 6:28. 2010
    ..Using this timeline of PDN, we can investigate the signaling mechanisms underlying mechanical allodynia in the db/db mouse...
  56. pmc Modeling nerve conduction criteria for diagnosis of diabetic polyneuropathy
    Peter J Dyck
    Peripheral Neuropathy Research Laboratory, Department of Neurology Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 44:340-5. 2011
    ..In this study we aimed to determine which criteria are valid for nerve conduction (NC) diagnosis of typical diabetic sensorimotor polyneuropathy (DSPN)...
  57. ncbi Elevated glycosylated hemoglobin is associated with subclinical neuropathy in neurologically asymptomatic diabetic patients: a prospective study
    Khalid El-Salem
    Department of Neurosciences, Jordan University of Science and Technology, Irbid, Jordan
    J Clin Neurophysiol 26:50-3. 2009
    ..Therapies for diabetic neuropathy should target the early stages of the disease...
  58. pmc Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion
    Catherine L Martin
    Diabetes Control and Complications Trial DCCT Epidemiology of Diabetes Intervention and Complications EDIC Research Group, Bethesda, MD 20892, USA
    Diabetes Care 29:340-4. 2006
    ..To evaluate the impact of prior intensive diabetes therapy on neuropathy among former Diabetes Control and Complications Trial (DCCT) participants...
  59. ncbi A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy
    Tingting Han
    Department of Endocrinology, Renji Hospital, Shanghai Jiaotong University, 200127 Shanghai, China
    Eur J Endocrinol 167:465-71. 2012
    ..To evaluate the effects and safety of 300-600 mg α-lipoic acid (ALA) given i.v. for diabetic peripheral neuropathy (DPN)...
  60. pmc Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice
    Kristina K Beiswenger
    Department of Pathology 0612, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0612, United States
    Neurosci Lett 442:267-72. 2008
    ..These data suggest that impaired epidermal nociceptor function contributes to early diabetes-induced thermal hypoalgesia prior to the loss of peripheral terminals...
  61. ncbi Direct insulin signaling of neurons reverses diabetic neuropathy
    Valentine Brussee
    Department of Clinical Neurosciences and the Neuroscience Research Group, University of Calgary, Calgary, Alberta, Canada
    Diabetes 53:1824-30. 2004
    ..Defective direct signaling of insulin on peripheral neurons through routes that include the cerebrospinal fluid may relate to the development of diabetic peripheral neuropathy...
  62. ncbi Cardiovascular autonomic neuropathy due to diabetes mellitus: clinical manifestations, consequences, and treatment
    Raelene E Maser
    Department of Medical Technology, 305F Willard Hall Education Building, University of Delaware, Newark, Delaware 19716, USA
    J Clin Endocrinol Metab 90:5896-903. 2005
    ..The aim of this article was to review the importance of the clinical identification of persons with cardiovascular autonomic neuropathy (CAN) and discuss potential treatment interventions...
  63. ncbi Diabetic neuropathy: therapies on the horizon
    Danish Mahmood
    Department of Pharmacology, Hamdard University, Hamdard Nagar, New Delhi 110062, India
    J Pharm Pharmacol 61:1137-45. 2009
    ..The pathology of DN is characterized by progressive nerve fibre loss that gives rise to positive and negative clinical signs and symptoms such as pain, paraesthesiae and loss of sensation...
  64. ncbi Cigarette smoking and diabetes
    Bjorn Eliasson
    Lundberg Laboratory for Diabetes Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Prog Cardiovasc Dis 45:405-13. 2003
    ..In diabetes care, smoking cessation is of utmost importance to facilitate glycemic control and limit the development of diabetic complications...
  65. ncbi Simple screening tests for peripheral neuropathy in the diabetes clinic
    B A Perkins
    Beth Israel Deaconness Medical Center and Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 24:250-6. 2001
    ..The reported operating characteristics for each sensory modality can be applied to positive findings on the physical examination of individual patients to predict the likelihood of neuropathy...
  66. pmc Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons
    Megan O Jacus
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosci 32:9374-82. 2012
    ..These studies provide previously unknown information regarding the role of presynaptic T-channels in nociceptive signaling in the spinal cord...
  67. pmc Enhanced glucose control for preventing and treating diabetic neuropathy
    Brian C Callaghan
    Department of Neurology, University ofMichigan, Ann Arbor, Michigan, USA
    Cochrane Database Syst Rev 6:CD007543. 2012
    ..Enhanced glucose control is the best studied intervention for the prevention of this disabling condition but there have been no systematic reviews of the evidence...
  68. ncbi Neuropathy and impaired glucose tolerance: an updated review of the evidence
    Y A Rajabally
    Neuromuscular Clinic, Department of Neurology, University Hospitals of Leicester, UK
    Acta Neurol Scand 124:1-8. 2011
    ..However, at present time, consideration of IGT as potential cause of painful small-fibre neuropathy appears justified, especially as patients may benefit from dietary and physical exercise interventions...
  69. pmc Microvascular perfusion abnormalities of the Thalamus in painful but not painless diabetic polyneuropathy: a clue to the pathogenesis of pain in type 1 diabetes
    Dinesh Selvarajah
    Diabetes Research Department, Royal Hallamshire Hospital, Sheffield, UK
    Diabetes Care 34:718-20. 2011
    ..The pathogenesis of painful diabetic neuropathy (DN) remains undetermined, with both central and peripheral mechanisms implicated. This study investigates whether thalamic perfusion abnormalities occur in painful DN...
  70. ncbi Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) at the spinal cord
    C Morgado
    Faculty of Medicine of Porto and IBMC, Institute of Histology and Embryology, University of Porto, Alameda Prof Hernani Monteiro, Porto, Portugal
    Diabetes Obes Metab 13:150-9. 2011
    ....
  71. pmc Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K
    Caroline A Abbott
    Division of Cardiovascular Medicine, Core Technology Facility, University of Manchester, Manchester, UK
    Diabetes Care 34:2220-4. 2011
    ....
  72. ncbi Controlled-release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy
    C Peter N Watson
    University of Toronto, Toronto, ON, Canada
    Pain 105:71-8. 2003
    ..Painful neuropathy is one of the most common long-term complications of diabetes mellitus and often proves difficult to relieve...
  73. pmc Animal models of peripheral neuropathies
    Ahmet Hoke
    Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    Neurotherapeutics 9:262-9. 2012
    ..Future clinical trials will be needed to validate the translational usefulness of this outcome measure and validation against accepted outcome measures that rely on clinical symptoms or examination findings in patients...
  74. pmc Heart rate variability and sensorimotor polyneuropathy in type 1 diabetes
    Steven Orlov
    Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:809-16. 2012
    ..Reduced heart rate variability (HRV) is classically viewed as an early phenomenon in diabetic sensorimotor polyneuropathy (DSP). We aimed to determine the characteristics of HRV across the spectrum of clinical DSP in type 1 diabetes...
  75. pmc Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy
    M Tavakoli
    Division of Cardiovascular Medicine, University of Manchester and Manchester Royal Infirmary, Manchester, UK
    Diabet Med 28:1261-7. 2011
    ..We have assessed whether corneal confocal microscopy can be used to detect alterations in nerve morphology following an improvement in risk factors associated with diabetic neuropathy...
  76. pmc Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats
    Hanna Shevalye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 61:2126-33. 2012
    ..Clinical studies are needed to determine if Metanx finds use in management of diabetic peripheral neuropathy...
  77. pmc Abnormal LDIflare but normal quantitative sensory testing and dermal nerve fiber density in patients with painful diabetic neuropathy
    Singhan T M Krishnan
    The Diabetes Centre, Ipswich Hospital, Ipswich, UK
    Diabetes Care 32:451-5. 2009
    ..The value of this technique in painful neuropathy was assessed by comparing it with QST and dermal nerve fiber density (NFD)...
  78. ncbi Corneal structure and sensitivity in type 1 diabetes mellitus
    M E Rosenberg
    Department of Ophthalmology, University of Helsinki, Finland
    Invest Ophthalmol Vis Sci 41:2915-21. 2000
    ..The purpose of this study was to examine patients with type 1 diabetes mellitus for changes in corneal morphology and to correlate corneal sensitivity, subbasal nerve morphology, and degree of polyneuropathy with each other...
  79. ncbi Evaluation of peripheral and autonomic neuropathy among patients with newly diagnosed impaired glucose tolerance
    Baris Isak
    Marmara University, Department of Neurology, Istanbul, Turkey
    Diabetes Metab Res Rev 24:563-9. 2008
    ....
  80. pmc Low peripheral nerve conduction velocities and amplitudes are strongly related to diabetic microvascular complications in type 1 diabetes: the EURODIAB Prospective Complications Study
    Morten Charles
    School of Public Health, Aarhus University, Aarhus, Denmark
    Diabetes Care 33:2648-53. 2010
    ..Because subjective or clinical indicators of neuropathy do not always match well with the presence of abnormal nerve physiology tests, we evaluated associations to nerve conduction in patients with type 1 diabetes...
  81. ncbi Treating diabetic peripheral neuropathic pain
    Tammy J Lindsay
    St Louis University Family Medicine Residency Program, Belleville, IL 62220, USA
    Am Fam Physician 82:151-8. 2010
    ..Because patients often have multiple comorbidities, physicians must consider potential adverse effects and possible drug interactions before prescribing a medication...
  82. ncbi Quantitative sensory testing: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    M E Shy
    Department of Neurology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA
    Neurology 60:898-904. 2003
    ..This assessment evaluates the clinical utility, efficacy, and safety of quantitative sensory testing (QST)...
  83. ncbi Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat
    X Chen
    Departments of Anatomy, Medicine, and Oral and Maxillofacial Surgery, Division of Neuroscience, NIH Pain Center (UCSF, University of California, San Francisco 94143-0440, USA
    Neuroscience 102:185-92. 2001
    ..The present findings suggest that study of individual neurons in vitro may allow elucidation of the ionic basis of enhanced nociception in diabetic neuropathy...
  84. ncbi Diabetic neuropathies: unanswered questions
    Yadollah Harati
    Baylor Neuropathy Center and Muscle and Nerve Otology Laboratory, Department of Neurology, Baylor College of Medicine, 6550 Fannin Street, 1801, Houston, TX 77030, USA
    Neurol Clin 25:303-17. 2007
    b>Diabetic neuropathies are the most common types of neuropathies worldwide...
  85. ncbi Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review
    Kate E Schemmel
    Mercy Medical Center, Dubuque, IA 52001, USA
    J Diabetes Complications 24:354-60. 2010
    ..The purpose of this article was to examine how aldose reductase (AR) inhibitors are used in the prevention and treatment of peripheral neuropathy in diabetes, specifically focusing on efficacy...
  86. ncbi Impaired glucose tolerance and neuropathy
    A Gordon Smith
    Department of Neurology, University of Utah, Salt Lake City, Utah 84132, USA
    Neurologist 14:23-9. 2008
    ..Among this population, impaired glucose tolerance (IGT or "prediabetes") is observed in approximately 40%. The exact nature of the relationship between IGT and neuropathy is debated...
  87. pmc Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice
    Tatsuhito Himeno
    Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes 60:2397-406. 2011
    ..The therapeutic potential of exendin-4, an agonist of the glucagon-like peptide-1 receptor (GLP-1R), on diabetic polyneuropathy (DPN) in streptozotocin (STZ)-induced diabetic mice was investigated...
  88. pmc Evaluation of oxidative stress markers in pathogenesis of diabetic neuropathy
    Jacek Kasznicki
    Department of Internal Medicine, Diabetology and Clinical Pharmacology, Medical University of Lodz, ul Parzeczewska 35, 95 100 Zgierz, Poland
    Mol Biol Rep 39:8669-78. 2012
    ..001). Our results confirm hypothesis that oxidative stress may play a substantial role in the development and progression of diabetic distal symmetric polyneuropathy...
  89. ncbi An exercise intervention to improve diabetic patients' gait in a real-life environment
    L Allet
    Care Services Directorate, Unit of Physiotherapy Research and Quality Assurance, Geneva University Hospital and University of Geneva, 1211 Geneva, Switzerland
    Gait Posture 32:185-90. 2010
    ..Gait characteristics and balance are altered in diabetic individuals. Little is known about possible treatment strategies. This study evaluated the effect of a specific training program on diabetic patients' gait...
  90. ncbi Altered sciatic nerve fiber morphology and endoneural microvessels in mouse models relevant for obesity, peripheral diabetic polyneuropathy, and the metabolic syndrome
    Marcin Nowicki
    Institute of Anatomy, University of Leipzig, Leipzig, Germany
    J Neurosci Res 90:122-31. 2012
    ..Upregulation of oxLDL-dependent receptors in endoneural microvessels might be connected to different degrees of oxidative stress in severe diabetic db/db mice and in the mild diabetic ob/ob group...
  91. ncbi Expression of aldose reductase and sorbitol dehydrogenase genes in Schwann cells isolated from rat: effects of high glucose and osmotic stress
    K Maekawa
    Division of Drug Evaluation, National Institute of Health Sciences, 1 1 43 Hoenzaka, Chuo Ku, Osaka 540 0006, Japan
    Brain Res Mol Brain Res 87:251-6. 2001
    ..The RT-PCR system developed in this study may be a useful tool in ascertaining the relative contributions of AR and SDH to the metabolic derangements leading to diabetic complications...
  92. ncbi Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats
    G M Khan
    Department of Anesthesiology H187, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Neuroscience 114:291-9. 2002
    ..Our electrophysiological data provide substantial new evidence that the abnormal sensory input from Adelta- and Abeta-fiber afferents may play an important role in diabetic neuropathic pain...
  93. ncbi Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy
    H X Zhuang
    Department of Physiology, Colorado State University, Fort Collins 80523, USA
    J Pharmacol Exp Ther 283:366-74. 1997
    ..These data suggest that IGF treatment may provide rational therapy for diabetic neuropathy and that therapy may be effective even in patients unable to adequately control their hyperglycemia...
  94. ncbi Diabetes-induced expression of activating transcription factor 3 in mouse primary sensory neurons
    Douglas E Wright
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Peripher Nerv Syst 9:242-54. 2004
    ..Finally, the ability to detect sensory deficits in diabetic mice occurs after the expression of injury-related gene ATF3, suggesting that nerve damage may be underway prior to the appearance of behavioral deficits...
  95. ncbi Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial
    Dan Ziegler
    FRCPE, Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Institut an der Heinrich Heine Universität, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:2365-70. 2006
    ..The aim of this trial was to evaluate the effects of alpha-lipoic acid (ALA) on positive sensory symptoms and neuropathic deficits in diabetic patients with distal symmetric polyneuropathy (DSP)...
  96. pmc Plantar pressure distribution patterns during gait in diabetic neuropathy patients with a history of foot ulcers
    Tatiana Almeida Bacarin
    Laboratory of Biomechanics of the Human Movement and Posture, Physical Therapy, Speech and Occupational Therapy Department, Faculdade de Medicina, Universidade de São Paulo SP, Brazil
    Clinics (Sao Paulo) 64:113-20. 2009
    ..To investigate and compare the influence of a previous history of foot ulcers on plantar pressure variables during gait of patients with diabetic neuropathy...
  97. ncbi Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy
    M J Stevens
    Division of Endocrinology and Metabolism, University of Michigan, Ann Arbor 48109 0678, USA
    Diabetes 49:1006-15. 2000
    ..They reveal complex interrelationships among nerve perfusion, energy metabolism, osmolyte content, conduction velocity, and oxidative stress that may reflect the heterogeneous and compartmentalized composition of peripheral nerve...
  98. pmc Nerve growth factor and diabetic neuropathy
    Gary Pittenger
    The Leonard Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
    Exp Diabesity Res 4:271-85. 2003
    ..b>Diabetic neuropathies are heterogeneous and there is variable involvement of large myelinated fibers and small, thinly ..
  99. pmc A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Eur J Pharmacol 569:48-58. 2007
    ..In conclusion, nitrosative stress plays an important role in sensory neuropathy associated with Type 1 diabetes. The findings provide rationale for further studies of peroxynitrite decomposition catalysts in a long-term diabetic model...
  100. ncbi Role of the Schwann cell in diabetic neuropathy
    Luke Eckersley
    Neuroscience Division, University of Manchester, School of Biological Sciences, Manchester M13 9PT, United Kingdom
    Int Rev Neurobiol 50:293-321. 2002
    ..This chapter discusses the role of the Schwann cell in the normal or regenerating nerve nad in the altered metabolic conditons of diabetes...
  101. ncbi Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction
    Andrey C da Costa Goncalves
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Hypertension 53:387-92. 2009
    ..Our data suggest that db/db mice exhibit features found in humans with type 2 diabetic autonomic neuropathy and could serve as a model for this complication...

Research Grants62

  1. MR Imaging of the Excitatory and Inhibitory Neurotransmitters in Chronic Pain
    Bradley Foerster; Fiscal Year: 2013
    ....
  2. Nerve Growth Factor Signaling in Painful Diabetic Neuropathy
    Hsinlin Thomas Cheng; Fiscal Year: 2013
    ..In this proposal we seek to identify new therapeutic targets for DNP based upon a more thorough understanding of the pathogenesis of this disorder. ..
  3. Spinal Matrix Metalloproteinases in Hyperalgesia and Allodynia
    CHRISTINA CHRISTIANSON; Fiscal Year: 2010
    ..initiated by a normally non-painful stimulus is present in conditions ranging from pancreatic cancer to diabetic neuropathies. Management of pain represents a major hurdle faced by the clinician during quality of life in these ..
  4. Methylglyoxal and TRPA1 contribution to neuropathic pain in type 2 diabetes
    RYAN B GRIGGS; Fiscal Year: 2013
    ..Our long-term objective is to substantially reduce the burden of neuropathic pain in type 2 diabetes. ..
  5. MODEL SYSTEMS FOR DEVELOPMENT OF PAIN GENE THERAPY
    Joseph C Glorioso; Fiscal Year: 2010
    ..We believe this to be a timely and highly innovative proposal which is likely to provide new approaches to treatment of chronic pain related to diabetes and inflammation. ..
  6. Chemokine Signaling in Diabetic Neuropathy
    Daniela M Menichella; Fiscal Year: 2013
    ....
  7. Group acupuncture for painful diabetic neuropathy among underserved patients
    Maria T Chao; Fiscal Year: 2013
    ..If the proposed aims are achieved, group acupuncture may provide a viable model for improving quality of life among underserved diabetes populations that can be implemented in safety net hospitals and other settings. ..
  8. Exercise-Facilitated NeuroRehabilitation in Diabetic Neuropathy
    EVAN STUBBS; Fiscal Year: 2009
    ..Although specific costs for treating diabetic neuropathies are not available, the potential savings with better management of diabetic neuropathies is evident given ..
  9. Effects of Acupuncture-Induced nNOS-NO in Dorsal Medulla on Sensory Neuropathy
    Sheng Xing Ma; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The most common forms of diabetic neuropathies are sensory dysfunctions with hyperalgesia and reduced temperature and vibration perception thresholds, which lead to very distressing and debilitating ..
  10. HYPERGLYCEMIA-INDUCED NEURONAL SENSITIZATION
    Judith Richter; Fiscal Year: 2001
    ..The studies on gabapentin provide a first example of this approach. ..
  11. REGULATION OF FAST AXONAL TRANSPORT DIABETIC NEUROPATHY
    SCOTT BRADY; Fiscal Year: 2004
    b>Diabetic neuropathies and their associated neurological complications represent one of the least tractable problems encountered in the clinics during long term management of the disease...
  12. Restoring diabetic tactile sense using mechanical noise
    Jason Harry; Fiscal Year: 2005
    More than 10 million individuals in the U.S. are thought to suffer from diabetic neuropathies. Many serious medical problems stem from this condition, including degradation of the mechanical senses of touch and proprioception...
  13. Painful HIV Neuropathy: Treatment with Alpha-Lipoic Acid
    J Mann; Fiscal Year: 2004
    ..Possible benefits of the study to patients with HIV-associated painful neuropathy include reduction in pain and disability, reduced use of medications and enhanced cellular metabolism. ..
  14. MODULATION OF RETINAL FUNCTION BY IGF-1
    Richard Kramer; Fiscal Year: 2001
    ..IGF-1 receptors are changed dramatically in diabetes, and have been proposed to play an integral part in diabetic neuropathies. The goal of this project is to understand more about the acute effects of IGF-l on the retina, with a ..
  15. Cortical Catheters
    Martin Brady; Fiscal Year: 2004
    ..distributions" (SCD's) within layers of cortex would perhaps also open the door to infusion therapies for diabetic neuropathies, Huntington's disease and other such syndromes and conditions...
  16. NEUROTROPHIN-3 IN SENSORY RECEPTOR ORGAN DEVELOPMENT
    ROBIN KRIMM; Fiscal Year: 2000
    ..g., diabetic neuropathies.
  17. MOLECULAR MECHANISMS OF RECEPTOR AND CHANNEL FUNCTION
    David Julius; Fiscal Year: 2002
    ..and facilitate the development of novel analgesic agents for treating peripheral pain syndromes, such as those associated with rheumatoid arthritis, viral and diabetic neuropathies, or peri-operative wound healing.
  18. Supraspinal mechanisms in painful diabetic neuropathy
    Thomas Morrow; Fiscal Year: 2007
    ..This research promises to identify critical supraspinal mechanisms of chronic neuropathic pain in diabetes mellitus. [unreadable] [unreadable]..
  19. SPINAL PLASTICITY IN DIABETIC NEUROPATHIC PAIN
    Hui Lin Pan; Fiscal Year: 2001
    ..This new information also could provide a rationale for development of new therapies for patients with diabetic neuropathic pain. ..
  20. Molecular Mechanism of Receptor and Channel Function
    DAVID J JULIUS; Fiscal Year: 2010
    ..for treating peripheral pain syndromes, such as those associated with rheumatoid arthritis, viral and diabetic neuropathies, or peri-operative wound healing...
  21. IGF I AND DIABETIC NEUROPATHIES
    ERIC RABINOVSKY; Fiscal Year: 2002
    b>Diabetic neuropathies are the most common complication of diabetes. Neuropathies can result in the loss of muscle strength, muscle atrophy and slowed nerve and muscle regeneration...
  22. Neurogenic Compounds for Treating Diabetic Complications
    REBECCA TIRABASSI; Fiscal Year: 2005
    ..Diabetic patients experience both cognitive impairment and a collection of syndromes termed "diabetic neuropathies"...
  23. Can dynamic pupillography and/or spectral analysis of heart rate variability prov
    Solomon Tesfaye; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. PROSAPOSIN AND PROSAPTIDES IN DIABETIC NEUROPATHY
    NIGEL CALCUTT; Fiscal Year: 2002
    ..The goal is to establish prosaptides as novel therapeutic agents for treating diabetic neuropathy and to provide mechanistic explanations for why hyperglycemia causes nerve disorders. ..
  25. Near Infra Red Energy To Treat Diabetic Neuropathy
    NIGEL CALCUTT; Fiscal Year: 2006
    ..abstract_text> ..
  26. Cyclooxygenase Pathway and Diabetic Neuropathy
    Rodica Pop Busui; Fiscal Year: 2005
    ..abstract_text> ..
  27. NEUROPATHOLOGY OF THE AGING SYMPATHETIC NERVOUS SYSTEM
    Robert Schmidt; Fiscal Year: 2006
    ..The results of these experiments should provide insight not only into autonomic dysfunction, but into a variety of pathologic processes in which NAD is a prominent component. ..
  28. EXPERIMENTAL DIABETIC AUTONOMIC NEUROPATHY
    ROBERT EDWARD SCHMIDT; Fiscal Year: 2010
    ..Thus, we are poised to understand the pathogenesis and develop novel therapies for diabetic autonomic neuropathy. ..
  29. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  30. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  31. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
  32. DIABETIC NEUROPATHY STUDY
    PETER DYCK; Fiscal Year: 2008
    ..mellitus (DM), impaired HbA1c and without DM (non-DM) aims at studying the frequency and heterogeneity of diabetic neuropathies by variety, characteristic features, course and emphasizing morbidity, disability, and adverse outcomes ..
  33. Mechanism of L channel-mediated neuronal survival
    John Marshall; Fiscal Year: 2004
    ..experiments will significantly advance our understanding of the mechanisms that regulate neuronal survival in the central nervous system, with particular relevance to diabetic neuropathies and traumatic disorders such as stroke.
  34. 2007 International Peripheral Nerve Society Meeting at Snowbird, Utah
    A Smith; Fiscal Year: 2007
    ..The meeting directly impacts public health and patient care by disseminating important new ideas (both research and therapeutic) and by developing consensus guidelines. [unreadable] [unreadable] [unreadable]..
  35. Taurine and Painful Diabetic Neuropathy
    Martin Stevens; Fiscal Year: 2007
    ..These studies will test a novel mechanistically based therapeutic approach to a common disabling and often-refractory complication of diabetes. ..
  36. Oxidative Stress and Nerve Pathology in Diabetes
    Andrew Mizisin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. Hyperglycemia-Induced Mechanical Hyperalgesia
    Maxim Dobretsov; Fiscal Year: 2006
    ..abstract_text> ..
  38. DYSREGULATION OF THE TAURINE TRANSPORTER IN DIABETES
    Martin Stevens; Fiscal Year: 2002
    ..As an alternative, if in aim 1 little correlation between hTT mRNA abundance and hTT activity is found, then glucose mediated post-translational modifications will be examined. ..
  39. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2006
    ..As part of this aim, a prototype device for easy use will be developed and tested in the clinical setting. ..
  40. ACHILLES TENDON LENGTHENING ON PATIENTS WITH DIABETES
    Michael Mueller; Fiscal Year: 2002
    ....
  41. Microbiology/Immunology of Periodontal Disease in T1DM
    Paul Moore; Fiscal Year: 2002
    ..An integrated multidisciplinary effort provides significant data collection capabilities essential for understanding the complex multifactorial etiology of periodontal disease in Type 1 diabetes. ..
  42. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2003
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  43. VISUALIZING DIABETIC FEET TO OPTIMIZE ORTHOTIC FITTING
    Michael Mueller; Fiscal Year: 2006
    ..Experimental testing will help to keep computational models realistic and valid while three dimensional computational modeling will enhance the scientific basis of orthotic design and testing. ..
  44. Ambulatory Foot Temperature in Diabetic Neuropathy
    SEWARD RUTKOVE; Fiscal Year: 2006
    ..Ultimately, the results obtained in this work may justify the use of ambulatory foot temperature monitoring in DN clinical trials, both as a screening tool for early disease and as an outcome measure. ..
  45. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  46. Impaired Wound Healing in Diabetic Foot Ulceration
    Aristidis Veves; Fiscal Year: 2010
    ..In addition we believe that it will be helpful in understanding the relationship between cardiovascular disease and wound healing. ..
  47. ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHY
    CHARLENE HAFER MACKO; Fiscal Year: 2002
    ....
  48. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2002
    ....
  49. Novel Risk Factors for Chronic Kidney Disease
    Ronald Klein; Fiscal Year: 2008
    ..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
  50. IGFS MEDIATE MOTILITY IN HUMAN NEUROBLASTOMA CELLS
    Eva Feldman; Fiscal Year: 2002
    ..Clearly, anti-growth factory therapy, targeted at specific genes, has both theoretical and practical appear in the treatment of NBL. ..
  51. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2005
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  52. NON-INVASIVE SURROGATE MARKERS FOR DIABETIC NEUROPATHY
    Andrew Boulton; Fiscal Year: 2004
    ....
  53. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2005
    ..We will also determine the mitochondrial metabolic effects that are most critical to both hypoxia-induced apoptosis and glucose protection in VSMCs. ..
  54. CHRONIC NEUROPATHIC PAIN MECHANISMS AND MANAGEMENT
    Michael Rowbotham; Fiscal Year: 2004
    ....
  55. Prenatal Exposure to Alcohol and Motor Timing Behavior
    Roger Simmons; Fiscal Year: 2005
    ..abstract_text> ..
  56. HUMAN AXONAL REGENERATION IN DIABETIC NEUROPATHY
    Michael Polydefkis; Fiscal Year: 2005
    ..Polydefkis the skills he needs to develop into an independent clinician researcher in the field of peripheral nerve disease. ..
  57. Microvascular - Macrovascular Disease in Type 2 Diabetes
    Ronald Klein; Fiscal Year: 2005
    ....
  58. Vascular and Metabolic Changes in the Diabetic Foot
    Aristidis Veves; Fiscal Year: 2005
    ..Therefore, the combination of MRI RARE measurements and HIS will effectively identify patients at risk of foot ulceration and also predict failure to heal an ulcer. ..
  59. Retinal Microvascular Characteristics/Vascular Disorders
    Ronald Klein; Fiscal Year: 2003
    ..abstract_text> ..
  60. GLUCOTOXICITY MEDIATES APOPTOSIS IN DIABETIC NEUROPATHY
    Eva Feldman; Fiscal Year: 2005
    ..Use genetically altered mice to characterize the death pathway in clinical diabetic neuropathy and determine the point of IGF-I protection ..
  61. PERIPHERAL NEUROPATHY, SENSORIMOTOR FUNCTIONS & BALANCE
    James Richardson; Fiscal Year: 2004
    ..Stratification of the subjects in the first group by the presence of carpal tunnel syndrome and testing the subjects in the second group at 3 and 12 weeks may give insight into the mechanisms responsible for improvement noted. ..