hyperesthesia

Summary

Summary: Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.

Top Publications

  1. ncbi Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model
    James J Lynch
    Neuroscience Research, Global Pharmaceutical Research and Development, Dept R4N5, Abbott Laboratories, Bldg AP9A LL, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Pain 110:56-63. 2004
  2. ncbi A role for G protein-coupled receptor kinase 2 in mechanical allodynia
    Wendy Kleibeuker
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, KC03 068 0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Eur J Neurosci 25:1696-704. 2007
  3. ncbi Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement
    T Graven-Nielsen
    Aalborg University, Aalborg, Denmark
    Arthritis Rheum 64:2907-16. 2012
  4. ncbi Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Pain 115:71-83. 2005
  5. ncbi Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation
    Cintia Sade de Paiva
    Ocular Surface Center, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    Am J Ophthalmol 137:109-15. 2004
  6. ncbi Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles
    P Svensson
    Center for Sensory Motor Interaction, Aalborg University, Denmark
    Pain 74:93-100. 1998
  7. ncbi Central representation of muscle pain and mechanical hyperesthesia in the orofacial region: a positron emission tomography study
    Ron C Kupers
    CFIN, Aarhus University and Aarhus University Hospitals, Aarhus, Denmark
    Pain 108:284-93. 2004
  8. ncbi Hyperesthesia: an early manifestation of diabetic polyneuropathy
    Masayuki Baba
    Intern Med 41:1079-80. 2002
  9. ncbi Analysis of spinal cord proteome in the rats with mechanical allodynia after the spinal nerve injury
    Sang Chul Lee
    Department of Anesthesiology, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Biotechnol Lett 25:2071-8. 2003
  10. ncbi Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain
    D C Broom
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neuroscience 124:891-900. 2004

Detail Information

Publications206 found, 100 shown here

  1. ncbi Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model
    James J Lynch
    Neuroscience Research, Global Pharmaceutical Research and Development, Dept R4N5, Abbott Laboratories, Bldg AP9A LL, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Pain 110:56-63. 2004
    ..The surprisingly good effects observed with acetaminophen warrant further investigation of its mechanism(s) of action in neuropathic pain...
  2. ncbi A role for G protein-coupled receptor kinase 2 in mechanical allodynia
    Wendy Kleibeuker
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, KC03 068 0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Eur J Neurosci 25:1696-704. 2007
    ..We propose cytokine-induced down-regulation of spinal cord neuronal GRK2 expression as a novel mechanism that contributes to increased neuronal signalling in mechanical allodynia...
  3. ncbi Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement
    T Graven-Nielsen
    Aalborg University, Aalborg, Denmark
    Arthritis Rheum 64:2907-16. 2012
    ..This study evaluated the importance of ongoing tissue pathology in the maintenance of enhanced central pain processing...
  4. ncbi Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Pain 115:71-83. 2005
    ..Taken together these data highlight the importance of microglial activation in the development of exaggerated pain states...
  5. ncbi Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation
    Cintia Sade de Paiva
    Ocular Surface Center, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    Am J Ophthalmol 137:109-15. 2004
    ..To evaluate corneal sensation in different groups: normal subjects, dry eye patients, and patients with and without dry eye after laser in situ keratomileusis (LASIK) using the modified Belmonte gas esthesiometer...
  6. ncbi Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles
    P Svensson
    Center for Sensory Motor Interaction, Aalborg University, Denmark
    Pain 74:93-100. 1998
    ..Similar hyperexcitability changes may be part of the pathophysiological mechanisms involved in painful temporomandibular disorders...
  7. ncbi Central representation of muscle pain and mechanical hyperesthesia in the orofacial region: a positron emission tomography study
    Ron C Kupers
    CFIN, Aarhus University and Aarhus University Hospitals, Aarhus, Denmark
    Pain 108:284-93. 2004
    ..jaw-muscle pain and its interference by simultaneous mechanical stimuli, which has been shown to evoke hyperesthesia. Ten healthy subjects participated in a PET study and jaw-muscle pain was induced by bolus injections of 5% ..
  8. ncbi Hyperesthesia: an early manifestation of diabetic polyneuropathy
    Masayuki Baba
    Intern Med 41:1079-80. 2002
  9. ncbi Analysis of spinal cord proteome in the rats with mechanical allodynia after the spinal nerve injury
    Sang Chul Lee
    Department of Anesthesiology, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Biotechnol Lett 25:2071-8. 2003
    ..Therefore, a lower creatine kinase B expression level may be important in the development and maintenance of neuropathic pain...
  10. ncbi Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain
    D C Broom
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neuroscience 124:891-900. 2004
    ..The pain hypersensitivity produced by the SNI model is not COX-2-dependent...
  11. ncbi Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation
    L R Gardell
    Department of Pharmacology, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 23:8370-9. 2003
    ..Thus, convergence of descending modulation, spinal plasticity, and afferent drive in the nerve-injured state reveals a mechanism by which some aspects of nerve injury-induced hyperesthesias may occur...
  12. ncbi Comparison of icilin- and cold-evoked responses of spinal neurones, and their modulation of mechanical activity, in a model of neuropathic pain
    Jennifer L Brignell
    Institute of Neuroscience, School of Biomedical Sciences, E Floor, Medical School, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Brain Res 1215:87-96. 2008
    ..Our data suggests that icilin modulates the mechanosensitivity of dorsal horn neurones. The differing effects of ice and icilin on dorsal horn neurones indicate different mechanisms of action...
  13. ncbi Quantifying allodynia in patients suffering from unilateral neuropathic pain using von frey monofilaments
    Doeke Keizer
    Department of Anesthesiology, Pain Management Center, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Clin J Pain 23:85-90. 2007
    ....
  14. ncbi Illusion of pain: pre-existing knowledge determines brain activation of 'imagined allodynia'
    Heidrun H Krämer
    Department of Neurology, University of Mainz, Mainz, Germany
    J Pain 9:543-51. 2008
    ..According to our results, the medial pain system is involved in the encoding of imagined allodynia...
  15. pmc Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models
    David I Hughes
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 27:2035-44. 2007
    ..They also suggest that any release of substance P from injured Abeta afferents is unlikely to activate NK1 receptors in the dorsal horn or contribute to neuropathic pain...
  16. pmc Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI
    Caterina Mainero
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 35:1201-10. 2007
    ..These results indicate that the pain modulatory system is involved to a different extent during primary versus secondary mechanical allodynia...
  17. ncbi Intracellular messengers involved in spontaneous pain, heat hyperalgesia, and mechanical allodynia induced by intrathecal dihydroxyphenylglycine
    Snijezanna S Ambrosini
    Department of Anesthesia, McGill University, Canada Department of Psychology, McGill University, Canada
    Neurosci Lett 409:224-9. 2006
    ..Neither PD 98059, nor GF 109203X, altered mechanical or thermal thresholds in saline-injected control rats. These results suggest that both ERK and PKC are involved in persistent pain associated with the i.t. administration of DHPG...
  18. ncbi Relief of post-herpetic neuralgia by surgical removal of painful skin
    Karin L Petersen
    Department of Neurology, UCSF Pain Clinical Research Center, University of California San Francisco, 1701 Divisadero Street, Suite 480, San Francisco, CA 94115, USA
    Pain 98:119-26. 2002
    ..The results may explain the anatomical basis of the capsaicin-response test and have implications for our understanding of clinical mechanisms underlying PHN pain...
  19. ncbi Thermal and tactile sensory deficits and allodynia in a nerve-injured patient: a multimodal psychophysical and functional magnetic resonance imaging study
    Robert K Hofbauer
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Clin J Pain 22:104-8. 2006
    ..A case study was conducted to examine a patient with chronic neuropathic pain of the right foot following peripheral nerve injury and characterize associated sensory abnormalities...
  20. pmc Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury
    Aldric Hama
    University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace R 48, Miami, FL 33136, USA
    Exp Neurol 204:454-7. 2007
    ..These data indicate that a CB(1)-selective agonist may be novel therapeutic treatment for clinical SCI pain...
  21. ncbi Assessment of nociception in acrylamide-induced neuropathy in rats
    Bing Ling
    Laboratoire de Toxicologie, Faculte de Pharmacie, EA 3848, 28 Place Henri Dunant, BP 38, 63001 Clermont Ferrand, France
    Pain 119:104-12. 2005
    ....
  22. ncbi Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation
    Wahida Rahman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Pain 123:264-74. 2006
    ....
  23. ncbi Evaluation of allodynia and pain associated with postherpetic neuralgia using current perception threshold testing
    Tetsuya Sakai
    Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan
    Clin J Pain 22:359-62. 2006
    ..This study was carried out to clarify the roles of peripheral sensory nerves in the production of allodynia and ongoing pain. Current perception threshold (CPT) testing was used to evaluate the sensory function...
  24. ncbi Tactile allodynia in patients with postherpetic neuralgia: lack of change in skin blood flow upon dynamic stimulation
    Marie Besson
    Pain Clinic, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Pain 117:154-61. 2005
    ..In conclusion, in a representative population of PHN patients we found no evidence of changes in SBF in response to allodynic stimulation. Hence, SBF measurements are not suitable for assessing allodynia...
  25. ncbi Increases in the activated forms of ERK 1/2, p38 MAPK, and CREB are correlated with the expression of at-level mechanical allodynia following spinal cord injury
    Eric D Crown
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Mail Route 1043 Galveston, TX 77555 1043, USA
    Exp Neurol 199:397-407. 2006
    ..Taken together, these results indicate that activation of intracellular signaling cascades traditionally associated with long-term potentiation and memory is associated with the expression of chronic CNP following SCI...
  26. ncbi Should cluster headache be associated with cutaneous allodynia?
    R Burstein
    Cephalalgia 26:1041-2. 2006
  27. pmc Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia
    Chun Ying Li
    Department of Anesthesiology, College of Medicine, University of California, Irvine, Irvine, California 92717, USA
    J Neurosci 24:8494-9. 2004
    ..Thus, changes in presynaptic alpha2delta-1 subunit expression contribute to injury-induced spinal neuroplasticity and central sensitization that underlies neuropathic pain development and maintenance...
  28. ncbi Quantitative sensory testing in cluster headache: increased sensory thresholds
    J Ladda
    Department of Neurology, University of Munich, Munich, Germany
    Cephalalgia 26:1043-50. 2006
    ....
  29. ncbi Mechanical allodynia and thermal hyperalgesia upon acute opioid withdrawal in the neonatal rat
    Sarah M Sweitzer
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Pain 110:269-80. 2004
    ..The present work illustrates the need to examine the phenomenon of hypersensitivity upon opioid withdrawal in the human pediatric population...
  30. ncbi The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury
    Mark A Oatway
    The Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, P O Box 5015, 100 Perth Drive, London, Ont, Canada N6A 5K8
    Pain 110:259-68. 2004
    ..However, the more long-lasting effects of this enhanced serotonergic input may facilitate chronic, at-level allodynia via the 5-HT(3)-R...
  31. ncbi Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
    Pain 126:294-308. 2006
    ..Together, these data suggest that intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control...
  32. ncbi Anti-allodynic effects of peripheral delta opioid receptors in neuropathic pain
    Noufissa Kabli
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ont, Canada K7L 3N6
    Pain 127:84-93. 2007
    ..Taken together, our findings suggest that functional peripheral DORs are present in sensory neurons following PNI and validate the development of selective DOR agonists for alleviating neuropathic pain...
  33. ncbi Attenuation of neuropathic pain by segmental and supraspinal activation of the dorsal column system in awake rats
    C El-Khoury
    Department of Human Morphology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Neuroscience 112:541-53. 2002
    ..This inhibition can be attributed to the activation of brainstem pain-modulating centers via rostral projections of the dorsal column nuclei...
  34. ncbi Lowered response threshold and increased responsiveness to mechanical stimulation of cutaneous nociceptive fibers in streptozotocin-diabetic rat skin in vitro--correlates of mechanical allodynia and hyperalgesia observed in the early stage of diabetes
    Yoshiaki Suzuki
    Department of Anesthesiology, Banbuntane Houtokukai Hospital, Fujita Health University, Nagoya, Japan
    Neurosci Res 43:171-8. 2002
    ..In addition, the response pattern to mechanical stimulation was also changed to a non-adapting type. These findings suggest that changes in CPRs contribute to the enhanced nociception observed in the early stage of diabetic neuropathy...
  35. ncbi Segmental hypersensitivity and spinothalamic function in spinal cord injury pain
    Nanna B Finnerup
    Danish Pain Research Center and Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
    Exp Neurol 207:139-49. 2007
    ....
  36. pmc Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors
    H X Liu
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:9960-4. 2001
    ..Thus, a selective GalR1 agonist may be used to treat neuropathic pain...
  37. ncbi Spinal pathways involved in supraspinal modulation of neuropathic manifestations in rats
    Nayef E Saade
    Department of Human Morphology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Pain 126:280-93. 2006
    ..The recovery of symptoms following spinal lesions provides illustration on the plasticity of the neural network involved in the processing of the neuropathic syndromes...
  38. ncbi The effect of menthol on cold allodynia in patients with neuropathic pain
    Gunnar Wasner
    Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    Pain Med 9:354-8. 2008
    ..We investigated the effects of menthol on preexisting cold allodynia in patients to test whether the allodynia was exacerbated...
  39. ncbi Pronociceptive actions of dynorphin maintain chronic neuropathic pain
    Z Wang
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    J Neurosci 21:1779-86. 2001
    ..Identification of mechanisms that maintain neuropathic pain appears important for strategies to treat neuropathic pain...
  40. ncbi Usefulness and limitations of quantitative sensory testing: clinical and research application in neuropathic pain states
    Per Hansson
    Dept of Neurosurgery, Pain Center, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Pain 129:256-9. 2007
  41. ncbi Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury
    R Terayama
    Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
    Neuroscience 153:1245-55. 2008
    ..Activation of p38 MAPK in medullary microglia may contribute to the pathogenesis of neuropathic pain...
  42. pmc Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats
    E J Rahn
    Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, GA 30602 3013, USA
    Br J Pharmacol 152:765-77. 2007
    ..The ability of cannabinoids to suppress mechanical hypersensitivity (mechanical allodynia) induced by treatment with the chemotherapeutic agent vincristine was evaluated in rats. Sites of action were subsequently identified...
  43. pmc Cutaneous endothelin-A receptors elevate post-incisional pain
    Florence H Mujenda
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Pain 133:161-73. 2007
    ..Post-incisional mechanical hyperesthesia was evaluated by cutaneous trunci muscle reflexes (CTMR) of subcutaneous muscles responding to stimulation ..
  44. pmc Alteration in the voltage dependence of NMDA receptor channels in rat dorsal horn neurones following peripheral inflammation
    H Guo
    Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555-1069, USA
    J Physiol 537:115-23. 2001
    ..7. These results indicate that NMDA receptor channel characteristics in the dorsal horn are altered by inflammation, and that the changes observed could contribute to the hyperalgesia and allodynia associated with tissue injury...
  45. ncbi Static mechanical allodynia (SMA) is a paradoxical painful hypo-aesthesia: observations derived from neuropathic pain patients treated with somatosensory rehabilitation
    C J Spicher
    Somatosensory Rehabilitation Centre, Clinique Generale, Fribourg, Switzerland
    Somatosens Mot Res 25:77-92. 2008
    ..The location of the axonal lesions is at the periphery, while the mechanism of pain sensitization is probably central and referred peripherally to the skin by a painful hypoaesthesia...
  46. ncbi Muscarinic receptor activation potentiates the effect of spinal cord stimulation on pain-related behavior in rats with mononeuropathy
    Zhiyang Song
    Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Institutet, Stockholm 171 76, Sweden
    Neurosci Lett 436:7-12. 2008
    ..In conclusion, the combination of SCS and a drug with selective muscarinic receptor agonistic properties could be an optional therapy, when SCS per se has proven inefficient...
  47. ncbi Different peripheral mechanisms mediate enhanced nociception in metabolic/toxic and traumatic painful peripheral neuropathies in the rat
    K O Aley
    NIH Pain Center UCSF, Box 0440, University of California San Francisco, 521 Parnassus Avenue, 94143 0440, USA
    Neuroscience 111:389-97. 2002
    ....
  48. ncbi Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity
    Jianren Mao
    Massachusetts General Hospital Pain Center and Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 22:8312-23. 2002
    ..These results indicate that spinal GTs may contribute to the neural mechanisms of morphine tolerance and associated abnormal pain sensitivity by means of regulating regional glutamate homeostasis...
  49. ncbi Tick-borne encephalitis virus as a possible cause of optic neuritis in a dog
    K Stadtbäumer
    Clinic for Surgery and Ophthalmology, University of Veterinary Medicine, Veterinarplatz 1, 1210 Vienna, Austria
    Vet Ophthalmol 7:271-7. 2004
    ..Anti-inflammatory therapy was stopped on day 18 after diagnosis. Four days later the dog showed evidence of hyperesthesia in the cervical region. Analysis of CSF showed no abnormalities and CSF IgG titers for TBEV and A...
  50. ncbi [Two outbreaks of eosinophilic meningitis in Yunann (China) clinical, epidemiological and therapeutical issues]
    Z Zhou
    The Second Affiliated Hospital of Kunming Medical University, Chine
    Bull Soc Pathol Exot 102:75-80. 2009
    ..b>Hyperesthesia due to radiculitis was observed in 68% of the cases and the meningitis syndrome was present in 41%...
  51. ncbi [Reflex sympathetic dystrophy secondary to piriformis syndrome: a case report]
    Didem Akcali
    Department of Anesthesiology and Reanimation, Algology Department, Gazi University Faculty of Medicine, Ankara, Turkey
    Agri 21:75-9. 2009
    ..Erythema and hyperalgesia was present in dorsum of the right foot. Right foot dorsiflexion was weak and hyperesthesia was found in right L4-5 dermatome...
  52. ncbi [Case of recurrent transverse myelitis and diplopia after meningomyeloradiculitis caused by Epstein-Barr virus]
    Masayuki Ochi
    Department of Geriatric Medicine, Medicine and Bioscience, Graduate School of Medicine, Ehime University
    Rinsho Shinkeigaku 47:348-52. 2007
    ..tests revealed neck stiffness, flaccid paraparesis in the legs with absent deep tendon reflexes, and hyperesthesia below Th7...
  53. ncbi Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy: a study of three cohorts. Nerve growth factor study group
    P J Dyck
    Peripheral Neuropathy Research Center, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Diabetes Care 23:510-7. 2000
    ..To test quantitative sensation testing (QST) patterns of hypoesthesia and hyperalgesia as indicators of diabetic polyneuropathy (DPN) and its severity..
  54. ncbi Surfer's myelopathy
    Todd P Thompson
    Department of Neurosurgery, Straub Clinic and Hospital, Honolulu, Hawaii
    Spine (Phila Pa 1976) 29:E353-6. 2004
    ..The authors reviewed a series of nontraumatic spinal cord injuries associated with surfing lessons...
  55. ncbi Paresthesia of the mental nerve stem from periapical infection of mandibular canine tooth: a case report
    Birkan Taha Ozkan
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Selcuk, Konya, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e28-31. 2008
    Sensory disturbances such as paresthesia, anesthesia, hypoesthesia, and hyperesthesia may be present in the oral cavity. Paresthesia is defined as a burning or prickling sensation or partial numbness caused by neural injury...
  56. ncbi Chronic pain and sensory changes after augmentation mammoplasty: long term effects of preincisional administration of methylprednisolone
    Luis Romundstad
    University of Oslo, Department Group of Clinical Medicine, Rikshospitalet University Hospital, Oslo, Norway
    Pain 124:92-9. 2006
    ..Methylprednisolone was associated with reduced odds for hyperesthesia at 1 year (OR 0.3, 95% CI 0.1-0...
  57. ncbi Development and characterization of a hemorrhagic rat model of central post-stroke pain
    J K Wasserman
    University of Toronto, Division of Anatomy, MSB 1186, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Neuroscience 161:173-83. 2009
    ..Behavioral analysis showed that animals displayed hyperesthesia in response to mechanical pinch stimulation, with sensitivity localized to the hind limb...
  58. ncbi Notalgia paresthetica: a study on pathogenesis
    E Savk
    Department of Dermatology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey
    Int J Dermatol 39:754-9. 2000
    ..The characteristic symptom is pruritus on the back, occasionally accompanied by pain, paresthesia, and/or hyperesthesia, which results in a well-circumscribed hyperpigmented patch in the symptomatic area...
  59. ncbi New mini-osteotomy of the infraorbital nerve in bony decompression for endocrine orbitopathy
    Luigi Clauser
    Unit of Craniomaxillofacial Surgery, Centre for Craniofacial Deformities and Orbital Surgery, Ferrara, Italy
    J Craniofac Surg 21:222-4. 2010
    ..Possible sensitivity disorders are paresthesia, anesthesia, hypoaesthesia, dysesthesia, and hyperesthesia.The innovation introduced by the first author in 2007 consists of a mini ostectomy around the infraorbital ..
  60. ncbi Benign symmetric lipomatosis (Launois-Bensaude syndrome)
    José Fernández-Vozmediano
    Dermatology Service, Puerto Real University Hospital, University of Cadiz, Spain
    Int J Dermatol 44:236-7. 2005
    ..2). The lesions produced a pulling sensation and were associated with paresthesia, hyperesthesia, and a moderate loss of strength in both arms...
  61. ncbi Feline leukemia virus-associated myelopathy in cats
    K P Carmichael
    Department of Veterinary Pathology, University of Georgia, Athens, USA
    Vet Pathol 39:536-45. 2002
    ..Clinical signs consisted of abnormal vocalization, hyperesthesia, and paresis progressing to paralysis...
  62. ncbi Labial dystonia after facial and trigeminal neuropathy controlled with a maxillary splint
    Manuel de Entrambasaguas
    Department of Clinical Neurophysiology, Hospital General de Castellon, Castellon, Spain
    Mov Disord 22:1355-8. 2007
    ..bite (Loxosceles rufescens) on the left cheek that caused severe local cellulitis, facial palsy, and painful hyperesthesia over the two lower trigeminal nerve divisions...
  63. ncbi [Reflex sympathetic dystrophy: a case report]
    M Kimura
    Department of Pediatrics, National Nishitottori Hospital, Tottori
    No To Hattatsu 27:487-91. 1995
    We described an 11-year-old boy with reflex sympathetic dystrophy (RSD). He presented symptoms of allodynia and hyperesthesia in the right foot with pale color and coldness. Before the onset he had abdominal pain and a change of taste...
  64. ncbi Recovery of corneal sensitivity to mechanical and chemical stimulation after laser in situ keratomileusis
    Juana Gallar
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Campus de San Juan, San Juan de Alicante, Spain
    J Refract Surg 20:229-35. 2004
    ..To evaluate the time course of changes in corneal sensitivity to mechanical and chemical stimuli produced by laser in situ keratomileusis (LASIK) in humans...
  65. ncbi [Anesthesia in a patient with congenital insensitivity to pain and anhidrosis]
    Carlos Rogério Degrandi Oliveira
    CET, Santa Casa, Santos
    Rev Bras Anestesiol 59:602-9. 2009
    ....
  66. ncbi Diagnostic criteria for CRPS I: differences between patient profiles using three different diagnostic sets
    Roberto S G M Perez
    Department of Anesthesiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Pain 11:895-902. 2007
    ..001), increase of symptoms due to exercise (p=0.009), edema (p=0.015), temperature asymmetry (p=0.015), hyperesthesia, allodynia (both p<0.001) and hyperalgesia (p=0.036)...
  67. ncbi Electrophysiologic evaluation of intermittent sacral nerve dysfunction in lumbar spinal canal stenosis
    Y Hiraizumi
    Department of Orthopaedic Surgery, University of Minnesota, Minneapolis
    Spine (Phila Pa 1976) 18:1355-60. 1993
    ..sacral nerve dysfunction, induced by walking in lumbar spinal canal stenosis, may cause symptoms including hyperesthesia and pain in perineum, urinary bladder incontinence, and penile erection...
  68. ncbi [Small fibre neuropathy: Diagnostic approach and therapeutic issues, and its association with primary Sjögren's syndrome]
    D Sene
    Service de Medecine Interne, Hopital Pitie Salpetriere, AP HP, Universite Paris 6, 75013 Paris, France
    Rev Med Interne 31:677-84. 2010
    ..presence of diffuse neuropathic painful manifestations (burning sensation, paresthesia, pricking, allodynia or hyperesthesia) and neurovegetative signs. The neurological examination and the electroneuromyogram are usually normal...
  69. ncbi Presumptive hepatotoxicity and rhabdomyolysis secondary to phenazopyridine toxicity in a dog
    Melissa L Holahan
    Department of Small Animal Clinical Sciences, D208 Veterinary Medical Center, Michigan State University, East Lansing, MI 48824 1314, USA
    J Vet Emerg Crit Care (San Antonio) 20:352-8. 2010
    ..To describe a rare, but potential clinical manifestation of phenazopyridine (PAP) toxicity in a dog...
  70. ncbi A nonsense mutation in the alpha1 subunit of the inhibitory glycine receptor associated with bovine myoclonus
    K D Pierce
    Neurobiology Program, Garvan Institute of Medical Research, Sydney, New South Wales, 2010, Australia
    Mol Cell Neurosci 17:354-63. 2001
    Inherited congenital myoclonus of Poll Hereford calves is an autosomal recessive disease characterized by hyperesthesia and myoclonic jerks of the skeletal musculature that occur both spontaneously and in response to sensory stimuli...
  71. ncbi Alcohol neurolysis for persistent pain caused by superior cluneal nerves injury after iliac crest bone graft harvesting in orthopedic surgery: report of four cases and review of the literature
    Ahmet Mahli
    Department of Anesthesiology and Reanimation, Gazi University Medical Faculty, Ankara, Turkey
    Spine (Phila Pa 1976) 27:E478-81. 2002
    ..common complication associated with this procedure is an alteration in sensation over the donor site manifested as chronic pain, hyperesthesia, dysesthesia, or diminished sensitivity resulting from superior cluneal nerve (SCN) injury.
  72. ncbi Suspected tolazoline toxicosis in a llama
    M R Read
    Department of Veterinary Anesthesiology, Radiology, and Surgery, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
    J Am Vet Med Assoc 216:227-9, 194. 2000
    ..v., half i.m. 45 minutes later, because the llama became weak and recumbent. Signs of anxiety, hyperesthesia, profuse salivation, and tachypnea were the first detectable clinical signs of tolazoline toxicosis...
  73. ncbi Electrophysiologic evidence of polyneuropathy in a cat with signs of bilateral brachial plexus neuropathy
    Paul M Freeman
    Department of Veterinary Medicine, University of Cambridge, Madingley Rd, Cambridge, CB3 0ES, England
    J Am Vet Med Assoc 234:240-4. 2009
    ..A 2-year-old spayed female domestic shorthair cat was examined because of bilateral thoracic limb weakness of acute onset...
  74. ncbi Littler's flap revisited: an anatomic study, literature review, and clinical experience in the reconstruction of large thumb-pulp defects
    Konstantinos C Xarchas
    Department of Orthopedics, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Greece
    Med Sci Monit 14:CR568-573. 2008
    ..An anatomic study and the authors' clinical experience with 15 flaps used for resurfacing sizable thumb defects are presented...
  75. ncbi Traumatic neuroma of the inferior alveolar nerve: a case report
    Ignacio Arribas-García
    Servicio de Cirugia Oral y Maxilofacial, Hospital Universitario 12 de Octubre, Av Cordoba s n 28041, Madrid, Spain
    Med Oral Patol Oral Cir Bucal 13:E186-8. 2008
    ..A 56-year-old man consulted for paresthesias and hyperesthesia in the left mandibular region following extraction of the left mandibular third molar (#38)...
  76. ncbi [Two cases of acute disseminated encephalomyelitis with lesions in the thalamus or basal ganglia on MRI]
    A Okumura
    Department of Pediatrics, Nagoya University School of Medicine
    No To Hattatsu 24:278-82. 1992
    ..Case 1, a 4-year-old boy, had gait disturbance, hyperesthesia and hyperreflexia...
  77. ncbi Sarcocystis neurona encephalitis in a dog
    A J Cooley
    College of Veterinary Medicine, Mississippi State University, Starkville, MS, USA
    Vet Pathol 44:956-61. 2007
    ..and resulted in a favorable initial response, but posterior paresis returned and progressed to recumbency, hyperesthesia, and attempts to bite the owner. The dog was euthanized...
  78. ncbi [A case of Churg-Strauss syndrome following corticosteroid withdrawal]
    Kishiko Sunami
    Department of Otorhinolaryngology, Graduate School of Medicine, Osaka City University, Osaka
    Nihon Jibiinkoka Gakkai Kaiho 112:487-90. 2009
    ..He then developed fever, maniphalanx stiffness, testicular pain, and facial hyperesthesia, eruptions, and the lower-limb numbness...
  79. ncbi Complex regional pain syndrome type II associated with lumbosacral plexopathy: a case report
    Andrew C Gallo
    Walter Reed Army Medical Center, Washington, DC 20307, USA
    Pain Med 11:1834-6. 2010
    ..CRPS Type II is most commonly caused by high velocity missile injuries, mononeuropathies, and partial nerve transections...
  80. ncbi Diagnosing sensory abnormalities with either normal values or values from contralateral skin: comparison of two approaches in complex regional pain syndrome I
    M A Kemler
    Department of Surgery, Maastricht University Hospital, Maastricht, The Netherlands
    Anesthesiology 93:718-27. 2000
    ..The current study gives normal values for both approaches and compares the advantages of each method by applying the technique to patients with complex regional pain syndrome type I (CRPS I)...
  81. ncbi Brown-Sequard syndrome associated with Horner's syndrome following a penetrating drill bit injury to the cervical spine
    Jeremy H Russell
    Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Australia
    J Clin Neurosci 16:975-7. 2009
    ..was not a complete hemisection of the spinal cord, the patient presented with ipsilateral motor deficit and hyperesthesia and diminished contralateral fine touch sensation; however, proprioception, vibration and temperature were all ..
  82. pmc Syringomyelia in three small breed dogs secondary to Chiari-like malformation: clinical and diagnostic findings
    Chul Park
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Vet Sci 10:365-7. 2009
    ..Upon physical and neurologic examination, all dogs displayed hyperesthesia, pain, and neck stiffness...
  83. ncbi Chronic ischemic monomelic neuropathy from critical limb ischemia
    D H Weinberg
    Department of Neurology, Tufts University School of Medicine, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Neurology 57:1008-12. 2001
    ..To describe the peripheral neuropathy resulting from chronic and critical arterial leg ischemia...
  84. ncbi Results of operative treatment of double Morton's neuroma in the same foot
    Kyung Tai Lee
    Foot and Ankle Service, Department of Orthopedic Surgery, Eulji Hospital, Eulji University, College of Medicine, Seoul, Republic of Korea
    J Orthop Sci 14:574-8. 2009
    ..Double Morton's neuroma in one foot has rarely been reported in the literature...
  85. ncbi Frey's syndrome after condylar fracture: case report
    Cassio Edvard Sverzut
    Department of Oral Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz Dent J 15:159-62. 2004
    Frey's syndrome is the occurrence of hyperesthesia, flushing and warmth or sweating over the distribution of the auriculotemporal nerve and/or greater auricular nerve while eating foods that produce a strong salivary stimulus...
  86. ncbi Primary subtalar arthrodesis of calcaneal fractures
    T Huefner
    Trauma Department, Hannover Medical School, Germany
    Foot Ankle Int 22:9-14. 2001
    ..In one patient with a painful arthritis in the talonavicular joint and hyperesthesia of the sural nerve, the results were fair...
  87. ncbi Management of dentinal hypersensitivity
    Alessandra Helen Magacho Vieira
    Department of Clinical Dentistry, Federal University of Ceara, Brazil
    Gen Dent 57:120-6; quiz 127-8. 2009
    ..of how applying a stimulus to the exposed dentin surface can influence the nerve fibers and produce hyperesthesia. This article reviews the etiology and critically analyzes management of dentinal hypersensitivity by ..
  88. ncbi Complex regional pain syndrome type 1 and scurvy
    Ravindra Kumar
    Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi, India
    Indian Pediatr 46:529-31. 2009
    ..Gum bleeding, petechiae and pseudoparalysis and suggestive radiograph characterized scurvy. Hyperesthesia improved and child walked with support following administration of vitamin C.
  89. ncbi Changes of sleep patterns in rats with chronic constriction injury under aversive conditions
    Shin Tokunaga
    Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1 1 1 Tsushima naka, Okayama, Japan
    Biol Pharm Bull 30:2088-90. 2007
    ..In addition, it was found that CCI rats placed on sandpaper as an aversive condition can serve as a new sleep disturbance model...
  90. pmc Improved identification of allodynic migraine patients using a questionnaire
    A Ashkenazi
    Department of Neurology, Thomas Jefferson University Hospital, Jefferson Headache Center, Philadelphia, PA, USA
    Cephalalgia 27:325-9. 2007
    ....
  91. pmc Pure epidural cavernous hemangioma of the cervical spine that presented with an acute sensory deficit caused by hemorrhage
    Byung June Jo
    Department of Diagnostic Radiology, Woordul Spine Hospital, Seoul, Korea
    Yonsei Med J 47:877-80. 2006
    ..Here, we report a case of a pure epidural cavernous hemangioma that presented with acute neurologic symptoms caused by intralesional hemorrhage and an acute epidural hematoma, which were demonstrated on the patient's MRI...
  92. ncbi The clinical challenge of chronic neuropathic pain
    K C P Vissers
    Department of Anaesthesiology, Critical Care and Multidisciplinary Pain Centre, Genk, Belgium
    Disabil Rehabil 28:343-9. 2006
    ..A correct management of chronic neuropathic pain requires a thorough understanding of the potential causes, the diagnosis and the pathophysiological mechanisms...
  93. ncbi Diagnostic criteria and follow-up parameters in complex regional pain syndrome type I--a Delphi survey
    Florian Brunner
    Department of Physical Medicine and Rheumatology, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, Switzerland
    Eur J Pain 12:48-52. 2008
    ..Although the current clinical guideline of diagnostic criteria for the complex regional pain syndrome I (CRPS I) is a landmark endeavour to define this complex condition it does not prioritise its most important clinical manifestations...
  94. ncbi Involvement of spinal glia in tetanically sciatic stimulation-induced bilateral mechanical allodynia in rats
    Bo Ying
    Institute of Neurobiology, Fudan University, Shanghai 200433, PR China
    Biochem Biophys Res Commun 340:1264-72. 2006
    ..The results showed that spinal glia plays an important role in bilaterally mechanical allodynia by tetanic sciatic stimulation of the sciatic nerve...
  95. ncbi 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors
    Shawn Maddaford
    NeurAxon Inc, 2395 Speakman Drive, Suite 1001, Mississauga, ON, Canada L5K 1B3
    Bioorg Med Chem Lett 21:5234-8. 2011
    ..One of the compounds, (R)-8 was shown to reduce tactile hyperesthesia (allodynia) after oral administration (30 mg/kg) in an in vivo rat model of dural inflammation relevant to ..
  96. ncbi [Neurinoma arising from brachial plexus with intrathoracic extension resected through the second intercostal space]
    Yuka Kitamura
    Department of Thoracic Surgery, Aichi Cancer Center Aichi Hospital, Okazaki, Japan
    Kyobu Geka 63:1133-5. 2010
    ..He had a complaint of hyperesthesia of the right upper arm for 2 months postoperatively.
  97. ncbi Age-dependency of analgesia elicited by intraoral sucrose in acute and persistent pain models
    Vanessa C Z Anseloni
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore 21201, USA
    Pain 97:93-103. 2002
    ..In inflamed animals, sucrose reduced hyperesthesia and hyperalgesia assessed with mechanical stimuli...
  98. ncbi Restless genital syndrome before and after clitoridectomy for spontaneous orgasms: a case report
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, 2545 CH The Hague, The Netherlands
    J Sex Med 7:1029-34. 2010
    ..Females despairing of restless genital syndrome (ReGS) may request clitoridectomy for treatment of unwanted genital sensations. Aim. The aim of this study was to report persistence of ReGS despite clitoridectomy...
  99. ncbi Small B-cell lymphoma presenting as diffuse dural thickening with cranial neuropathies
    Miguel Estevez
    Department of Neurology, University of Pittsburgh, PA, USA
    J Neurooncol 59:243-7. 2002
    ..Rapid expansion of the dura in this case resulted in profound hyperesthesia of the scalp, progressive blindness, deafness, and ataxia...
  100. ncbi Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain
    Katharine Walker
    Purdue Biopharma LP, 201 College Road East, Princeton, NJ 08540, USA
    Pain 100:219-29. 2002
    ..This unique property of zoledronic acid amongst the bisphosphonate class of compounds could make this drug a preferred choice for the treatment of painful bone metastases in the clinic...
  101. pmc Acute carpal tunnel syndrome from burns of the hand and wrist
    Chenicheri Balakrishnan
    Department of Plastic Surgery, Wayne State School of Medicine, Detroit, Michigan, USA
    Can J Plast Surg 17:e33-4. 2009
    ..Although the hyperesthesia from burns may mimic symptoms of acute compression neuropathy, clinical diagnosis should be made from history, ..

Research Grants12

  1. Supraspinal Modulation of Neuropathic Pain
    Bradley Taylor; Fiscal Year: 2007
    ..abstract_text> ..
  2. DRG EXCITABILITY AND POTASSIUM CHANNEL INHIBITOR
    Brian Cooper; Fiscal Year: 2000
    ..Regardless of the nature of predisposing events, individuals often report spontaneous burning pain and hyperesthesia. Animal models have indicated that peripheral nerve injuries produces changes in cellular activity and ..
  3. Problems and Competence under Age5: School Transition
    Alice Carter; Fiscal Year: 2005
    ....
  4. NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSION
    Bradley Taylor; Fiscal Year: 2008
    ..We predict that the activity of this population of spinal neurons will be decreased by NPY administration, and increased by NPY knockdown. ..
  5. Oxidative Stress and Nerve Pathology in Diabetes
    Andrew Mizisin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Individual Differences in Pain Modulation as Predictors of Post-Surgical Pain
    Robert Edwards; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Glutamate Uptake & the Pathogenesis of Neuropathic Pain
    Jianren Mao; Fiscal Year: 2007
    ..abstract_text> ..
  8. Neuropathic Pain Modulation by Cannabinoids
    Jianren Mao; Fiscal Year: 2006
    ..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
  9. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2005
    ....
  10. PAIN, OPIOID ANALGESIA AND BLOOD PRESSURE CONTROL
    Bradley Taylor; Fiscal Year: 2002
    ..The results of these studies will facilitate our understanding of the mechanisms that contribute to chronic pain in the hypertensive patient. ..
  11. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2010
    ....
  12. Catastrophizing and Pain in Rheumatoid Arthritis
    Robert Edwards; Fiscal Year: 2008
    ..abstract_text> ..