hyperalgesia

Summary

Summary: An increased sensation to painful stimuli that may follow damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve. Hyperalgesia can occur both at the site of tissue damage (primary hyperalgesia) and in the surrounding undamaged areas (secondary hyperalgesia). (Kandel et al., Principles of Neural Science, 3d ed, p386)

Top Publications

  1. ncbi Models and mechanisms of hyperalgesia and allodynia
    Jürgen Sandkühler
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Physiol Rev 89:707-58. 2009
  2. pmc Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    Alban Latremoliere
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    J Pain 10:895-926. 2009
  3. pmc Central sensitization: implications for the diagnosis and treatment of pain
    Clifford J Woolf
    FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
    Pain 152:S2-15. 2011
  4. ncbi Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis
    Francesco Ferrini
    Institut universitaire en santé mentale de Québec, Quebec, Canada
    Nat Neurosci 16:183-92. 2013
  5. ncbi Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
    Angelika Bierhaus
    Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
    Nat Med 18:926-33. 2012
  6. ncbi Opioid-induced hyperalgesia: a qualitative systematic review
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 104:570-87. 2006
  7. ncbi The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation
    Diogo Santos M da Costa
    Departament of Pharmacology, Universidade Federal de Santa Catarina, Florianopolis 88040 900, SC, Brazil
    Pain 148:431-7. 2010
  8. ncbi p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
  9. pmc Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5189-94. 2008
  10. ncbi Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pharmacol Exp Ther 306:624-30. 2003

Detail Information

Publications335 found, 100 shown here

  1. ncbi Models and mechanisms of hyperalgesia and allodynia
    Jürgen Sandkühler
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Physiol Rev 89:707-58. 2009
    b>Hyperalgesia and allodynia are frequent symptoms of disease and may be useful adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in their own right...
  2. pmc Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    Alban Latremoliere
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    J Pain 10:895-926. 2009
    ..Instead, central sensitization produces pain hypersensitivity by changing the sensory response elicited by normal inputs, including those that usually evoke innocuous sensations...
  3. pmc Central sensitization: implications for the diagnosis and treatment of pain
    Clifford J Woolf
    FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
    Pain 152:S2-15. 2011
    ..manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary punctate or pressure hyperalgesia, aftersensations, and enhanced temporal summation...
  4. ncbi Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis
    Francesco Ferrini
    Institut universitaire en santé mentale de Québec, Quebec, Canada
    Nat Neurosci 16:183-92. 2013
    A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates...
  5. ncbi Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
    Angelika Bierhaus
    Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
    Nat Med 18:926-33. 2012
    This study establishes a mechanism for metabolic hyperalgesia based on the glycolytic metabolite methylglyoxal...
  6. ncbi Opioid-induced hyperalgesia: a qualitative systematic review
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesthesiology 104:570-87. 2006
    ..accumulating evidence suggests that opioids may yet cause another problem, often referred to as opioid-induced hyperalgesia. Somewhat paradoxically, opioid therapy aiming at alleviating pain may render patients more sensitive to pain ..
  7. ncbi The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation
    Diogo Santos M da Costa
    Departament of Pharmacology, Universidade Federal de Santa Catarina, Florianopolis 88040 900, SC, Brazil
    Pain 148:431-7. 2010
    This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's Adjuvant (CFA) in mice. The intraplantar (i.pl...
  8. ncbi p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
    ..Coactivation of p38 in DRG neurons and spinal microglia may contribute to later phases of neuropathic pain...
  9. pmc Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5189-94. 2008
    ..response element-binding protein (CREB) phosphorylation in superficial dorsal horn neurons and produced heat hyperalgesia after spinal injection...
  10. ncbi Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pharmacol Exp Ther 306:624-30. 2003
    ..release of proinflammatory cytokines are known to play a role in inducing a behavioral hypersensitive state (hyperalgesia and allodynia) in these animals...
  11. ncbi Central mechanisms of pathological pain
    Rohini Kuner
    Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld, 366 Heidelberg, Germany
    Nat Med 16:1258-66. 2010
    ..the neural matrix of physiological pain and has also brought important advances in concepts of injury-induced hyperalgesia and tactile allodynia and how these might contribute to the complex, multidimensional state of chronic pain...
  12. pmc TRPA1 mediates mechanical sensitization in nociceptors during inflammation
    Richard C Lennertz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e43597. 2012
    ..that injection of the HC-030031 compound into the hind paw of inflamed mice alleviates behavioral mechanical hyperalgesia without affecting heat hyperalgesia...
  13. ncbi A comprehensive review of opioid-induced hyperalgesia
    Marion Lee
    Centers for Pain Management, Tifton, GA 31794, USA
    Pain Physician 14:145-61. 2011
    Opioid-induced hyperalgesia (OIH) is defined as a state of nociceptive sensitization caused by exposure to opioids...
  14. ncbi p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
    ....
  15. pmc Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta
    S S Lewis
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Neuroscience 165:569-83. 2010
    ..In vivo, intrathecal M3G (0.75 microg) induced potent allodynia and hyperalgesia, blocked or reversed by interleukin-1 receptor antagonist, minocycline (microglial inhibitor), and (+)-and (-)-..
  16. pmc ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury
    Roxanne Y Walder
    Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, Iowa, USA
    J Pain 11:210-8. 2010
    ..Prior behavioral studies in ASIC3-/- mice showed deficits in secondary hyperalgesia (increased response to noxious stimuli outside the site of injury) but not primary hyperalgesia (increased ..
  17. pmc Mechanisms of neuropathic pain
    James N Campbell
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuron 52:77-92. 2006
    ..The rapid gain in knowledge about abnormal signaling promises breakthroughs in the treatment of these often debilitating disorders...
  18. pmc Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice
    Robert E Sorge
    Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Neurosci 31:15450-4. 2011
    ..We found no sex differences in spinal Tlr4 gene expression at baseline or after LPS, suggesting the existence of parallel spinal pain-processing circuitry in female mice not involving TLR4...
  19. pmc Hyperalgesia by synaptic long-term potentiation (LTP): an update
    Jürgen Sandkühler
    Medical University of Vienna, Center for Brain Research, Department of Neurophysiology, Spitalgasse 4, A 1090 Vienna, Austria
    Curr Opin Pharmacol 12:18-27. 2012
    Long-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle features with hyperalgesia including induction protocols, pharmacological profile, neuronal and glial cell types involved and means for prevention...
  20. ncbi Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain
    Heike L Rittner
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
    J Leukoc Biol 79:1022-32. 2006
    ..We hypothesized that hyperalgesia does not develop after chemokine-induced PMN selective recruitment and is independent of PMN infiltration in ..
  21. pmc A cascade of cytokines mediates mechanical inflammatory hypernociception in mice
    T M Cunha
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, 14049 900, Ribeirao Preto, Brazil
    Proc Natl Acad Sci U S A 102:1755-60. 2005
    ..These results extend to mice the concept that the release of primary mediators responsible for hypernociception is preceded by a cascade of cytokines...
  22. ncbi Mechanisms of opioid-induced tolerance and hyperalgesia
    Anna DuPen
    Pain and Palliative Care Research Department, Swedish Medical Center, Seattle, Washington 98122 5711, USA
    Pain Manag Nurs 8:113-21. 2007
    Opioid tolerance and opioid-induced hyperalgesia are conditions that negatively affect pain management...
  23. ncbi Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing
    Camilla I Svensson
    Department of Anesthesiology, University of California, San Diego, La Jolla, California, USA
    J Neurochem 86:1534-44. 2003
    ..However, they attenuated hyperalgesia in several nociceptive models associated with spinal sensitization including direct spinal activation (..
  24. ncbi The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain
    Penny C Staton
    Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Pain 139:225-36. 2008
    ..at the CB(1) and CB(2) receptors are effective analgesic and anti-inflammatory agents, the role of GPR55 in hyperalgesia associated with inflammatory and neuropathic pain has been investigated...
  25. pmc Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder
    H Henry Lai
    Department of Surgery, Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Pain 152:2117-24. 2011
    ..However, data regarding the roles of spinal ERK1/2 in the development of visceral hyperalgesia are sparse...
  26. ncbi Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain
    Ulf Baumgartner
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Pain 96:141-51. 2002
    ..of capsaicin (n=7) and A-fiber conduction blockade (n=8) served as human surrogate models for neurogenic hyperalgesia and partial nociceptive deafferentation, respectively...
  27. pmc Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel
    H Saegusa
    Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University and CREST, Japan Science and Technology Corporation, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    EMBO J 20:2349-56. 2001
    ..This finding clearly demonstrates that the N-type VDCC is essential for development of neuropathic pain and, therefore, controlling the activity of this channel can be of great importance for the management of neuropathic pain...
  28. ncbi Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
    Joanna Mika
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Cracow, Poland
    Eur J Pharmacol 560:142-9. 2007
    ..that microglial cells which are strongly activated in neuropathy can influence development of allodynia and hyperalgesia. Here we demonstrated that preemptive and repeated i.p...
  29. ncbi A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    Zhi Ye Zhuang
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3551-60. 2006
    ..Targeting the JNK pathway in spinal astroglia may present a new and efficient way to treat neuropathic pain symptoms...
  30. pmc Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 30:8624-36. 2010
    ..attenuated formalin-induced spontaneous nocifensive responses and tissue or nerve injury-induced allodynia and hyperalgesia. Furthermore, in control shRNA-treated animals, intra-RVM microinjection of brain-derived neurotrophic factor ..
  31. ncbi Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain
    E Polgar
    Spinal Cord Group, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Pain 104:229-39. 2003
    ..in the latency of withdrawal of the ipsilateral hindpaw to a radiant heat stimulus, suggesting that thermal hyperalgesia had developed...
  32. ncbi KCNQ/M currents in sensory neurons: significance for pain therapy
    Gayle M Passmore
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:7227-36. 2003
    ..It is suggested that IK(M) plays a key role in controlling the excitability of nociceptors and may represent a novel analgesic target...
  33. ncbi Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
    W Magerl
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Brain 124:1754-64. 2001
    ..skin between two skin areas that had been pretreated with either capsaicin cream or vehicle produced secondary hyperalgesia with a 260% enhancement of the stimulus-response function for pinprick pain in both areas...
  34. ncbi ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 22:478-85. 2002
    ..Activation of the ERK pathway in a subset of nociceptive spinal neurons contributes, therefore, to persistent pain hypersensitivity, possibly via transcriptional regulation of genes, such as prodynorphin and NK-1...
  35. ncbi The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Italy
    Pain 139:541-50. 2008
    ..This therapeutic regimen evoked a relief of both thermal hyperalgesia and mechanical allodynia in neuropathic mice...
  36. ncbi A new model of visceral pain and referred hyperalgesia in the mouse
    J M Laird
    Department of Physiology, University of Alcala, Alcala de Henares, E 28871, Madrid, Spain
    Pain 92:335-42. 2001
    ..Mustard oil and capsaicin administration evoked dose-dependent visceral pain behaviours, referred hyperalgesia (significant increase in responses to von Frey hairs) and colon plasma extravasation...
  37. ncbi Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain
    Maria Osikowicz
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Pain 139:117-26. 2008
    ..antagonist), LY379268 (mGluR2/3 agonist), and AMN082 (mGluR7 agonist) attenuated allodynia (von Frey test) and hyperalgesia (cold plate test) as measured in Swiss albino mice on day seven after chronic constriction injury (CCI) to the ..
  38. pmc Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia
    B Safieh Garabedian
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 115:1265-75. 1995
    ..These may contribute to inflammatory pain and hyperalgesia by directly or indirectly altering the function or chemical phenotype of responsive primary sensory neurones. 2...
  39. ncbi Opioid-induced hyperalgesia: a review of epidemiology, mechanisms and management
    Yinghui Low
    Department of Anesthesiology, Duke University Medical Center, Durham, USA
    Singapore Med J 53:357-60. 2012
    There has been a growing interest in opioid-induced hyperalgesia (OIH), which is an increased sensitivity to pain caused by opioid exposure...
  40. ncbi Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration
    Ruth Drdla-Schutting
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, A 1090 Vienna, Austria
    Science 335:235-8. 2012
    ..LTP at C-fiber synapses represents a cellular model for pain amplification (hyperalgesia) and for a memory trace of pain...
  41. pmc Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Mol Pain 6:13. 2010
    ..Here we asked whether cytokines, which have well-described roles in inflammatory pain, are downstream targets of NO in inflammatory pain and which of the isoforms of NOS are involved in this process...
  42. ncbi Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation
    Stefan P Ivanavicius
    In Vivo Pharmacology, AstraZeneca, Alderley Park, Mereside, Cheshire SK10 4TG, UK
    Pain 128:272-82. 2007
    ..Collectively, these data suggest that this putative model of OA is associated with an early phase neuropathy in the L5 innervation territory of the knee...
  43. ncbi Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK
    Niels Eijkelkamp
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
    J Neurosci 30:12806-15. 2010
    ..via which nociceptor G-protein-coupled receptor kinase 2 (GRK2) contributes to regulation of inflammatory hyperalgesia. We show that nociceptor GRK2 is downregulated during inflammation...
  44. ncbi The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats?
    Rachel Combe
    Pain Therapeutics, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT139NJ, UK
    Neurosci Lett 370:236-40. 2004
    ..In conclusion, the MIA model of OA is reproducible and mimics OA pain in humans. Analgesic drug studies indicate this model may be useful for investigating chronic nociceptive pain...
  45. pmc Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat
    Paul G Green
    Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA 94143 0440, USA
    Pain 152:2549-56. 2011
    ..Furthermore, administration of prostaglandin E(2) in skin as well as muscle produced markedly prolonged hyperalgesia, an effect prevented by spinal intrathecal injection of oligodeoxynucleotide antisense to protein kinase Cε (..
  46. ncbi A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging
    L Zambreanu
    Pain Imaging Neuroscience PaIN Group, Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 3QX, UK
    Pain 114:397-407. 2005
    ..RVM), in the development and maintenance of central sensitisation and its clinical manifestation, secondary hyperalgesia. Similar evidence in humans is lacking, as neuroimaging studies have mainly focused on cortical changes...
  47. ncbi The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization
    Parisa Gazerani
    Laboratory for Experimental Pain Research, Centre for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg, Denmark
    Pain 122:315-25. 2006
    ..Intradermally capsaicin-induced pain, flare and secondary hyperalgesia were obtained before and 1, 4 and 8 weeks after the above treatments...
  48. ncbi Quantitative sensory testing: a comprehensive protocol for clinical trials
    R Rolke
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstr 21, D 55099 Mainz, Germany
    Eur J Pain 10:77-88. 2006
    ..Our rationale was to test for patterns of sensory loss (small and large nerve fiber functions) or gain (hyperalgesia, allodynia, hyperpathia), and to assess both cutaneous and deep pain sensitivity...
  49. pmc TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    J Clin Invest 115:2393-401. 2005
    Cold hyperalgesia is a well-documented symptom of inflammatory and neuropathic pain; however, the underlying mechanisms of this enhanced sensitivity to cold are poorly understood...
  50. ncbi Nerve growth factor contribution via transient receptor potential vanilloid 1 to ectopic orofacial pain
    Masamichi Shinoda
    Department of Physiology, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    J Neurosci 31:7145-55. 2011
    ..The exact mechanism of such an orofacial ectopic hyperalgesia remains unclear...
  51. ncbi Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia
    Joyce A DeLeo
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Neuroscientist 10:40-52. 2004
    ..emerged as a promising therapeutic target for the treatment and prevention of chronic pain and opioid tolerance/hyperalgesia is the modulation of the central nervous system (CNS) immunological response that ensues following injury or ..
  52. ncbi The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity
    Fumimasa Amaya
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:12852-60. 2006
    ..9-/- mice. Na(v)1.9 is, we conclude, an effector of the hypersensitivity produced by multiple inflammatory mediators on nociceptor peripheral terminals and therefore plays a key role in mediating peripheral sensitization...
  53. ncbi Excitatory amino acid receptor antagonists and electroacupuncture synergetically inhibit carrageenan-induced behavioral hyperalgesia and spinal fos expression in rats
    Yu Qiu Zhang
    Institute of Neurobiology, Fudan University, 220 Han Dan Road, Shanghai 200433, China
    Pain 99:525-35. 2002
    ..6,7-dinitroquinoxaline-2,3 (1H,4H); DNQX) administered intrathecally on carrageenan-induced thermal hyperalgesia and spinal c-Fos expression was investigated...
  54. ncbi Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats
    Kenjiro Nagamine
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pain 7:659-70. 2006
    ..Inoculation of cancer cells induced marked mechanical allodynia and thermal hyperalgesia in the ipsilateral maxillary and mandibular nerve area...
  55. pmc The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition
    Yong Jing Gao
    Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 148:309-19. 2010
    Peripheral inflammation induces persistent central sensitization characterized by mechanical allodynia and heat hyperalgesia that are mediated by distinct mechanisms...
  56. pmc Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization
    Marina N Asiedu
    Department of Pharmacology, The University of Arizona College of Medicine, Tucson, AZ 85721, USA
    J Neurosci 31:6646-53. 2011
    ....
  57. pmc The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia
    Qin Liu
    Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Sci Signal 4:ra45. 2011
    ..Therefore, although both Mrgpr and PAR2 are SLIGRL-responsive G protein-coupled receptors present in dorsal root ganglia, each plays a specific role in mediating itch and pain...
  58. pmc Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior
    Jeong Il Choi
    Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA
    Pain 149:243-53. 2010
    ....
  59. ncbi Secondary hyperalgesia to heat stimuli after burn injury in man
    J L Pedersen
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark
    Pain 76:377-84. 1998
    The aim of the study was to examine the presence of hyperalgesia to heat stimuli within the zone of secondary hyperalgesia to punctate mechanical stimuli...
  60. ncbi Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels
    Yumi Maeda
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Pain 142:127-32. 2009
    ..pl.) administration of NaHS, a donor of H2S, causes prompt hyperalgesia in rats. In this context, we asked whether intrathecal (i.t...
  61. ncbi Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons
    Chao Ma
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurophysiol 89:1588-602. 2003
    ..SNL produced lasting hyperalgesia to punctate indentation and tactile allodynia to innocuous stroking of the foot ipsilateral to the injury...
  62. pmc Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process
    Aaron Mickle
    Division of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pain 149:555-64. 2010
    ..on visceral hypersensitivity and to explore the site of action using a rat model of post-inflammatory visceral hyperalgesia. In all rats, a baseline viscero-motor response (VMR) to graded colorectal distension (CRD; 10-60mmHg) was ..
  63. ncbi Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats
    Bahareh Amin
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    Fitoterapia 83:888-95. 2012
    ..radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i.e., one day before surgery and 3, 5, 7 and 10 days post surgery...
  64. ncbi Hyperalgesia in a human model of acute inflammatory pain: a methodological study
    J L Pedersen
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark
    Pain 74:139-51. 1998
    The aim of the study was to examine reproducibility of primary and secondary hyperalgesia in a psychophysical model of human inflammatory pain...
  65. pmc The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant
    Lu Yu
    Neuroscience Research Institute, School of Basic Medical Sciences, Peking University, Beijing, PR China
    Mol Pain 4:61. 2008
    ..receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons in chronic pain including thermal hyperalgesia and mechanical allodynia...
  66. ncbi Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesia
    Rachel Groth
    Department of Biology, Macalester College, 1600 Grand Ave, Saint Paul, MN 55105, USA
    Pain 100:171-81. 2002
    ..oligodeoxynucleotide treatment produces antinociception in normal mice and attenuates carrageenan-induced hyperalgesia. Further, we demonstrate that i.t. antisense treatment directed against the full-length trkB receptor (trkB...
  67. ncbi Modulation of pain processing in hyperalgesia by cognitive demand
    Katja Wiech
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 27:59-69. 2005
    ..task on pain-evoked neural responses in an experimental model of chronic pain, the capsaicin-induced heat hyperalgesia model...
  68. pmc A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states
    Sandrine M Géranton
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 29:15017-27. 2009
    ....
  69. ncbi The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosci 22:9980-9. 2002
    Hypersensitivity resulting from nerve injury or morphine tolerance/hyperalgesia is predicted to involve similar cellular and molecular mechanisms...
  70. ncbi Effects of dopaminergic agents on carrageenan hyperalgesia after intrathecal administration to rats
    X Gao
    Department of Neurobiology, State Key Laboratory of Medical Neurobiology, Medical Center of Fudan University, 200032, Shanghai, China
    Eur J Pharmacol 418:73-7. 2001
    ..quinoline hydrochloride (LY171555), a dopamine D(2) receptor agonist, produced anti-hyperalgesia (150 and 300 nmol) or hypoalgesia (300 nmol) in the inflamed hindpaws and non-inflamed hindpaws, respectively; ..
  71. ncbi Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity
    Kyung Min Lee
    Department of Anatomy, Pain and Neural Injury Research Center, MRC, School of Medicine, Kyungpook National University, 2 101, Dongin Dong, Daegu, 700 422, South Korea
    Eur J Neurosci 19:3375-81. 2004
    ..namely, NF-kB decoy or pyrrolidine dithiocarbamate, significantly reduced mechanical allodynia and thermal hyperalgesia following unilateral hindpaw inflammation evoked by complete Freund's adjuvant (CFA)...
  72. ncbi Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, 1 242 Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
    Pain 106:229-39. 2003
    Clinically, chronic pain and hyperalgesia induced by muscle injury are disabling and difficult to treat. Cellular and molecular mechanisms underlying chronic muscle-induced hyperalgesia are not well understood...
  73. ncbi Pain elicited by blunt pressure: neurobiological basis and clinical relevance
    R D Treede
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstrasse 21, D 55099, Mainz, Germany
    Pain 98:235-40. 2002
  74. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
    ..Fos and NR1 in the spinal cord, and the effects of IL-1 receptor antagonist (IL-1ra) on NR1 phosphorylation and hyperalgesia in a rat model of inflammatory pain...
  75. ncbi The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance
    Jean Paul Laulin
    Universite Bordeaux 1, France
    Anesth Analg 94:1263-9, table of contents. 2002
    ..However, a morphine administration at the end of the fentanyl effects restored the long-lasting hyperalgesia. Repeated ketamine administrations were required to obtain a complete preventive effect...
  76. ncbi Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers
    G Wu
    Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 21:RC140. 2001
    Ligation and transection of the L5 spinal nerve in the rat lead to behavioral signs of pain and hyperalgesia. Discharge of injured nociceptors has been presumed to play a role in generating the pain...
  77. ncbi Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat
    L R Watkins
    Department of Psychology, University of Colorado at Boulder, 80309, USA
    Pain 71:225-35. 1997
    Subcutaneous (s.c.) injection of formalin induces a rapid and prolonged hyperalgesia across widespread areas of the body. This hyperalgesic state involves a brain-to-spinal cord pathway, likely arising from the nucleus raphe magnus...
  78. pmc TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization
    Nicole Alessandri-Haber
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Neurosci 29:6217-28. 2009
    The transient receptor potential vanilloid 4 (TRPV4) contributes to mechanical hyperalgesia of diverse etiologies, presumably as part of a mechanoreceptor signaling complex (Alessandri-Haber et al., 2008)...
  79. ncbi Synaptic amplifier of inflammatory pain in the spinal dorsal horn
    Hiroshi Ikeda
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Science 312:1659-62. 2006
    Inflammation and trauma lead to enhanced pain sensitivity (hyperalgesia), which is in part due to altered sensory processing in the spinal cord...
  80. ncbi Characterisation of ultraviolet-B-induced inflammation as a model of hyperalgesia in the rat
    T Bishop
    Neurorestoration Group, The Wolfson Centre for Age Related Diseases, King s College London, The Wolfson Wing, Hodgkin Building, Guy s Campus, London Bridge, London SE1 1UL, United Kingdom
    Pain 131:70-82. 2007
    ..UV) radiation is well studied and the sensory changes that are found have been used as a model of cutaneous hyperalgesia. Similar paradigms are now emerging as rodent models of inflammatory pain...
  81. ncbi Induction of synaptic long-term potentiation after opioid withdrawal
    Ruth Drdla
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria
    Science 325:207-10. 2009
    ..treatment of severe pain but may paradoxically also enhance pain sensitivity, that is, lead to opioid-induced hyperalgesia (OIH)...
  82. pmc In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy
    Richard B Messinger
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, VA 22908, USA
    Pain 145:184-95. 2009
    ..diabetes in rats leads to the development of painful peripheral diabetic neuropathy (PDN) manifested as thermal hyperalgesia and mechanical allodynia accompanied by significant enhancement of T-type calcium currents (T-currents) and ..
  83. pmc Evidence that opioids may have toll-like receptor 4 and MD-2 effects
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:83-95. 2010
    ..including: opposition of acute and chronic opioid analgesia, opioid analgesic tolerance, opioid-induced hyperalgesia, development of opioid dependence, opioid reward, and opioid respiratory depression...
  84. pmc Intraepidermal nerve fiber loss corresponds to the development of taxol-induced hyperalgesia and can be prevented by treatment with minocycline
    J Boyette-Davis
    Department of Anesthesiology and Pain Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA
    Pain 152:308-13. 2011
    ..Animals receiving minocycline plus Taxol showed no hyperalgesia or loss of IENFs...
  85. ncbi Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines
    Vasudeva Raghavendra
    Department of Anesthesiology, HB 7125, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Pain 104:655-64. 2003
    Injury to peripheral nerves often produces non-physiological, long-lasting spontaneous pain, hyperalgesia and allodynia that are refractory to standard treatment and often insensitive to opioids, such as morphine...
  86. ncbi Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain
    Sameer Sharma
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 536:256-61. 2006
    ..Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose and decreased body weights as compared with control mice...
  87. ncbi Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
    ....
  88. ncbi Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain
    T Philip Malan
    Department of Anesthesiology, The University of Arizona, Tucson, Arizona 85724 5114, USA
    Anesthesiology 96:1161-7. 2002
    This study tests the hypothesis that loss of spinal activity of gamma-aminobutyric acid (GABA) contributes to the allodynia and hyperalgesia observed after peripheral nerve injury.
  89. ncbi Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations
    Larry F Chu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    Clin J Pain 24:479-96. 2008
    Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive sensitization caused by exposure to opioids...
  90. ncbi Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice
    Punam Gauchan
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neurosci Lett 458:93-5. 2009
    ..These results suggest that cold allodynia induced by oxaliplatin is at least partly due to the increased expression of TRPM8 in the primary afferents...
  91. ncbi Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia
    K A Sluka
    Physical Therapy Graduate Program, 2600 Steindler Bldg, University of Iowa, Iowa City, Iowa 52242, USA
    Muscle Nerve 24:37-46. 2001
    This study characterizes an animal model of persistent mechanical hyperalgesia induced by repeated intramuscular injections of low pH saline. Saline at pH 4, 5, 6, or 7...
  92. ncbi A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity
    DongHoon Kim
    Program in Molecular and Cellular Neuroscience, Dental Research Institute, BK21, and Department of Oral Physiology, School of Dentistry, Seoul National University, Seoul 110 749, Korea
    J Biol Chem 282:14975-83. 2007
    ..that the expression of toll-like receptor 2 is required for the induction of mechanical allodynia and thermal hyperalgesia due to spinal nerve axotomy...
  93. ncbi Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states
    S K Joshi
    Abbott Laboratories, Neuroscience Research, Abbott Park, IL 60064, USA
    Pain 123:75-82. 2006
    ..8 sodium channel have been reported to decrease inflammatory hyperalgesia and L5/L6 spinal nerve ligation-induced mechanical allodynia in rats...
  94. ncbi Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study
    Christian Geber
    Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany
    Pain 152:548-56. 2011
    ....
  95. pmc Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia
    Qinghao Xu
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 31:2113-24. 2011
    ..The functional linkages of this signaling cascade in spinal dorsal horn and their role in inflammatory hyperalgesia have not been elucidated. In the present work, we identified the following characteristics of this cascade...
  96. ncbi A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21201, USA
    Brain Res 1020:18-29. 2004
    We previously reported the anti-hyperalgesia of electroacupuncture (EA) on persistent inflammatory pain in an unrestrained, unsedated, and conscious rat model...
  97. ncbi Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury
    Zheng Gen Piao
    Department of Physiology, College of Dentistry and Dental Research Institute, Seoul National University, Seoul 110 749, Republic of Korea
    Pain 121:219-31. 2006
    ..These results suggest that glial activation in MDH plays an important role in the development of neuropathic pain and activation of p38 MAPK in hyperactive microglia contributes to pain hypersensitivity in IAMNT model...
  98. ncbi Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
    Romina Nassini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Pain 152:1621-31. 2011
    ..One single administration of oxaliplatin produced mechanical and cold hyperalgesia in rats, an effect selectively abated by the TRPA1 antagonist HC-030031...
  99. pmc Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat
    Shuangsong Hong
    Department of Internal Medicine and Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 279:29341-50. 2004
    ..TTX-S) and TTX-R sodium channels in dorsal root ganglion (DRG) neurons and the responses to thermal hyperalgesia and mechanical allodynia in streptozotocin-treated rats between 4-8 weeks after onset of diabetes...
  100. ncbi Hydrogen sulfide as a novel nociceptive messenger
    Atsufumi Kawabata
    Division of Physiology and Pathophysiology, Department of Pharmacy, School of Pharmacy, Kinki University, Higashi Osaka 577 8502, Japan
    Pain 132:74-81. 2007
    ..Intraplantar (i.pl.) administration of NaHS, a H(2)S donor, produced prompt hyperalgesia in rats, accompanied by expression of Fos in the spinal dorsal horn...
  101. pmc The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome
    Guang Yin Xu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0655, USA
    Mol Pain 5:44. 2009
    ..a role for hydrogen sulfide (H2S) in pain signaling but this has not been well studied in visceral models of hyperalgesia. We therefore determined the role for the endogenous H2S producing enzyme cystathionine-beta-synthetase (CBS) ..

Research Grants72

  1. Hyperalgesia in Methadone Patients: Can it be Treated?
    Margaret Compton; Fiscal Year: 2007
    ..the pain suffered by the over 120,000 methadone-maintained (MM) patients in this country, in part because the hyperalgesia they suffer appears to be akin to neuropathic pain and opioid-induced...
  2. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    ..The hardwired expression pattern predisposes nociceptive neurons innervating the GI tract to hyperalgesia in response to colorectal distension in the setting of chronic intermittent stress...
  3. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..channels that are implicated in somatic and visceral pain (TrpV1, TrpA1), and GFLs can produce analgesia and hyperalgesia. We will delineate genes expressed in Ret-positive DRG sensory neurons...
  4. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
    ..determined that interruption of activity in abdominal vagal afferents results in a state of enhanced mechanical hyperalgesia. This vagotomy-induced generalized hyperalgesia depends on adrenal medulla function, a characteristic highly ..
  5. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ..of ion channels in pain transduction, as sensitization to painful stimuli during inflammation (inflammatory hyperalgesia) profoundly influences our physical and mental health, as well as our economic and social well-being...
  6. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    ..The exact mechanism of IBS is poorly understood but mounting evidence suggests that visceral hyperalgesia and psychosocial stress play important roles in the pathogenesis...
  7. Modulation of Colonic Epithelial Permeability by Sex Hormones
    Muriel Larauche; Fiscal Year: 2013
    ..the role of gonadal hormones and sex chromosome complements in the sex difference in stress-induced visceral hyperalgesia and examine the influence of gonadal hormones on the recruitment and activity of colonic mucosal mast cells...
  8. Epigenetic regulation in neuropathic pain
    Zhonghui Guan; Fiscal Year: 2013
    ..to normally innocuous stimuli (allodynia) and exaggerated pain in response to normally painful stimuli (hyperalgesia). Many of these changes are the product and/or the cause of lasting alterations in gene expression...
  9. Systemic Application for Injury Site Specific Delivery via Neutrophils to Treat B
    XUDONG J LI; Fiscal Year: 2013
    ..anti-oxidative and anti-inflammatory properties, without specific biological target could not only reduce hyperalgesia induced by the extrusion of nucleus pulposus tissue from herniated discs, but also eliminate the side effects ..
  10. Presynaptic NMDAR Regulation of Substance P Release in the RVM After Injury
    UCHECHUKWU PATRICK MADUKA; Fiscal Year: 2013
    ..Thus, local antagonism of neurokinin-1 receptors in the RVM was sufficient to reversal hyperalgesia and hypersensitivity induced by complete Freund's adjuvant (CFA)...
  11. Stress and Visceral Hyperalgesia: Epigenetic Mechanisms
    John W Wiley; Fiscal Year: 2012
    ..that chronic stress activates epigenetic regulatory pathways resulting in enhanced abdominal pain (visceral hyperalgesia)...
  12. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori A Birder; Fiscal Year: 2013
    ..These studies will examine mechanisms underlying this type of nonneuronal allodynia/hyperalgesia. Understanding the mechanisms contributing to and maintaining these types of changes may provide important ..
  13. Central Nervous System Mechanisms in Knee Osteoarthritis (KOA)
    Daniel J Clauw; Fiscal Year: 2013
    ..Such factors include diffuse hyperalgesia or allodynia, and/or a lack of endogenous descending analgesic activity 6,8, 9 ...
  14. Neuron-specific block of T-type calcium channels
    Edward Perez-Reyes; Fiscal Year: 2012
    ..2 directed antisense oligonucleotides reverse the mechanical hyperalgesia and allodynia observed in these animals. Importantly, Cav3...
  15. Regulation of Hepatic Uptake of Endogenous Signaling Molecules and Xenobiotics
    Ivan Csanaky; Fiscal Year: 2013
    ..body temperature during surgical experiments, but are protected from lipopolysaccharide-induced hypothermia and hyperalgesia. The objective of this proposal is to use Oatp1b2-null and heterozygous mice as well as in vitro cellular and ..
  16. Varicella zoster virus-Induced Pain in a Rat Model of Post-Herpetic Neuralgia
    Paul R Kinchington; Fiscal Year: 2013
    ..to FOA PA-07-282, and will center on a new clinically relevant model of VZV-induced pain in which prolonged hyperalgesia and allodynia occur following injection of human VZV into the rat hindpaw...
  17. THE ROLE FOR THE GPR30 RECEPTOR IN INFLAMMATORY PAIN
    Jill C Fehrenbacher; Fiscal Year: 2010
    ..estradiol and G-1, a specific agonist for the GPR30, elicit increases in inflammation-induced orofacial thermal hyperalgesia in female rats, but have no effect on thermal sensitivity in saline-injected animals...
  18. MECHANICAL STIMULATION OF IVD CELLS
    Lori A Setton; Fiscal Year: 2013
    ..Here, rats will be evaluated for parameters of gait, allodynia, and thermal hyperalgesia prior to and after transforaminal delivery of in situ forming curcumin-ELP depots;all data will be compared ..
  19. Mechanisms underlying TMD-IBS comorbidity
    Richard J Traub; Fiscal Year: 2013
    ..persistent pain combined with stress alters the endogenous analgesia system resulting in enhanced secondary hyperalgesia in close proximity to the initial painful site, but also in hypersensitivityin distal deep tissue...
  20. PROTEINASE-ACTIVATED RECEPTORS/PERIPHERAL NERVOUS SYSTEM
    Nigel W Bunnett; Fiscal Year: 2010
    ..that sensitize ion channels, resulting in release of neuropeptides, which cause neurogenic inflammation and hyperalgesia to inflammatory, thermal, mechanical and osmotic stimuli...
  21. Urocortin &Musculoskeletal Hyperalgesia
    Alice A Larson; Fiscal Year: 2013
    ..abdominal nociception and our preliminary data suggest that urocortins simultaneously induce musculoskeletal hyperalgesia. Second, urocortins inhibit circulating glucocorticoids, consistent with a diminished diurnal rhythm and ..
  22. Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action
    Daniel Shoskes; Fiscal Year: 2013
    ..b>Hyperalgesia will be assessed for sensation perception and pain threshold at 3 frequencies that measure function of 3 nerve ..
  23. Characteristics and mechanisms of pain in sickle cell disease
    DONALD SIMONE; Fiscal Year: 2013
    ..data indicate that mice with SCD exhibit cutaneous (mechanical, heat and cold) and deep (decreased grip force) hyperalgesia similar to that observed in patients with SCD...
  24. THE ROLE OF METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5) IN BLADDER PAIN
    HING HUNG HENRY LAI; Fiscal Year: 2013
    ..Our preliminary data show that in a mouse model of bladder pain, development of bladder hyperalgesia is associated with robust spinal cord ERK1/2 activation (phosphorylation)...
  25. Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide
    Xinmin Simon Xie; Fiscal Year: 2013
    ..damage cause the development of neuromas with associated localized chronic pain manifested as allodynia and hyperalgesia. Approximately 30% of these neuromas become sufficiently painful that the affected digit, hand or limb becomes ..
  26. Effects of Artemin on Nociceptors
    KATHRYN MARIE ALBERS; Fiscal Year: 2013
    ..Aim 3 will determine whether nAChR subunits contribute to inflammatory thermal hyperalgesia using a newly developed siRNA procedure that will reduce expression of specific nAChR subunits in peripheral ..
  27. Role of peroxynitrite in morphine hyperalgesia and tolerance
    Daniela Salvemini; Fiscal Year: 2012
    ..The mechanisms of such opiate-induced hyperalgesia and antinociceptive tolerance are unclear. Peroxynitrite (ONOO-) produced from superoxide (O2...
  28. Functional Interactions between Cancer Cells and Sensory Neurons
    DONALD SIMONE; Fiscal Year: 2012
    ..Previous behavioral studies from our group indicated that ATP contributes to the development of hyperalgesia in a murine model of bone cancer. Moreover, opioids modulate signaling at P2X receptors...
  29. Genome Wide Identification of PTF1-J Targets in Dorsal Neural Tube
    Jane E Johnson; Fiscal Year: 2010
    ..Alterations in this balance are thought to underlie diverse neurological disorders from epilepsy to autism to hyperalgesia. Successful completion of these aims will substantially advance efforts to define transcriptional networks ..
  30. Lipid Regulation of Transient Receptor Potential Channels
    Tibor Rohacs; Fiscal Year: 2013
    ..Sensitization plays an important role in thermal hyperalgesia, a disturbing symptom in neuropathic pain syndromes...
  31. Endocannabinoid signaling in a model of cancer pain
    Virginia S Seybold; Fiscal Year: 2013
    ..Indeed, we have generated evidence that increased degradation of AEA in skin is associated with mechanical hyperalgesia in a murine model of bone cancer pain...
  32. Corticotropin-Releasing Factor Action on GI Function
    YVETTE FRANCE TACHE; Fiscal Year: 2012
    ..CRF1 signaling plays also a prominent role in stress-related stimulation of colonic motor function and visceral hyperalgesia in rodents...
  33. CaMKII as a Mechanism &Intervention Target for Sickle Cell Pain
    Zaijie Jim Wang; Fiscal Year: 2013
    ..In these preliminary studies, we found the presence of tactile allodynia and thermal hyperalgesia and that spinal CaMKII expression and activity were upregulated, similar to what we observed in other mouse ..
  34. Central mechanisms of maintenance of orofacial pain after injury
    Asaf Keller; Fiscal Year: 2013
    ..Recent findings suggest that behavioral hyperalgesia following injury persists despite a reduction in peripheral neuronal activity suggesting that peripheral drive ..
  35. Characterization and Plasticity of Visceral Nociceptors
    Brian M Davis; Fiscal Year: 2012
    ..expressing TRPV1 and/or TRPA1, two channels that have been shown to be required for development of inflammatory hyperalgesia. We also found that all members of the GDNF family of growth factors could, like NGF, sensitize primary sensory ..
  36. Spinal glia activation in chronic stress-induced visceral hyperalgesia
    Sylvie Bradesi; Fiscal Year: 2013
    ..visceral sensitivity and determine the molecular pathways engaged in the initiation and maintenance of visceral hyperalgesia. Our first specific aim is to assess the temporal profile of spinal glia activation during and after chronic ..
  37. Exertional Exhaustion in CFS
    James N Baraniuk; Fiscal Year: 2013
    ..In addition, they share sleep alterations, diverse nociceptive complaints, migraine, and systemic hyperalgesia. This overlap suggests that these syndromes share specific mechanisms of neural pathophysiology...
  38. Mechanisms of Neuropathic Pain in Demylenated Nerves
    Fletcher A White; Fiscal Year: 2010
    ..We will determine whether the chronic cutaneous hyperalgesia exhibited by animals subjected to focal nerve demyelination is correlated with the degree of inflammatory ..
  39. Cannabinoid-based therapy and approaches to quantify pain in sickle cell disease
    Kalpna Gupta; Fiscal Year: 2013
    ..Sickle mice show hyperalgesia which is further elevated by H/R and attenuated by non-selective cannabinoid receptor agonist CP55940...
  40. Alpha2-adrenoceptors modulate TRPV4 and reduce inflammation-induced visceral pain
    MARTIN R WATTS; Fiscal Year: 2013
    ..Transient receptor potential vanilloid 4 (TRPV4), which has been implicated in inflammatory hyperalgesia and visceral pain and is upregulated in the colons of IBD patients, is activated by phosphorylation...
  41. Neuronal Changes in Adult Rats Induced by Neonatal Pain
    Adrian Miranda; Fiscal Year: 2011
    ..may contribute to central sensitization and play a major role in the development of somatic and visceral hyperalgesia. The goal of this proposal is to investigate alterations in visceral sensation and underlying neuronal ..
  42. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2013
    ..We will also ask if CaV2.2-e37a channels are required for hyperalgesia to develop with neuropathic pain, and if they are necessary to mediate the analgesic effects of morphine during ..
  43. Mechanisms of Spontaneous Neuropathic Pain
    Frank Porreca; Fiscal Year: 2013
    ..While nerve injury-induced evoked hypersensitivity (i.e., allodynia/hyperalgesia) and spontaneous neuropathic pain are likely to involve some common mechanisms, we hypothesize that evoked and ..
  44. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2010
    ..be replaced by CCI of the infraorbital nerve &assessment of orofacial mechanical allodynia &thermal hyperalgesia. Together these studies will provide novel insights into the actions of opioid analgesics at both trigeminal &..
  45. Investigation and treatment of central nervous system dysfunction in chronic pelv
    Felipe Fregni; Fiscal Year: 2010
    ..Furthermore we will assess the impact of this treatment on the phenomenon of allodynia and hyperalgesia, which are known to be surrogates of central sensitization...
  46. Clinical Development of 4-Cl-KYN to Treat Pain
    RALPH SNODGRASS; Fiscal Year: 2010
    ..In contrast, GlyB antagonists inhibit NMDA receptor function, reduce hyperalgesia and allodynia in neuropathic pain models, and have fewer side effects than classic NMDA receptor antagonists, ..
  47. Spinal TNF elicits AMPAr trafficking and hyperalgesia
    Linda S Sorkin; Fiscal Year: 2013
    ..The proposal explores the possibility that TNF, via several identified steps, causes insertion of more and more active glutamate receptors into neuronal membranes to make them more excitable. ..
  48. BHLH TRANSCRIPTION FACTORS IN NEURAL DEVELOPMENT
    Jane E Johnson; Fiscal Year: 2013
    ..and excitatory neurons are thought to underlie diverse neurological disorders from epilepsy to autism to hyperalgesia. Ptf1a is an essential regulator of this balance in multiple regions of the nervous system, and thus, factors ..
  49. Persistent Pain and Opioid Mechanisms in the Rostroventral Medial Medulla
    MARLENE CANO; Fiscal Year: 2011
    ..of the mechanisms by which 5 opioid receptor (MOPr) agonists suppress acute nociception and relieve hyperalgesia in persistent pain states will provide important insights into these adaptive changes...
  50. Modulation of Colonic Response to Stress by Peripheral CRF2 Receptors
    MILLION MULUGETA; Fiscal Year: 2012
    ..peripheral CRF2 serves as a stress-coping signal that halts stress-induced colonic motility and visceral hyperalgesia through a direct and indirect action on peripheral target cells...
  51. Mixed NOP/mu compounds and the involvement of their receptors in analgesia.
    LAWRENCE R TOLL; Fiscal Year: 2013
    ..The ability of NOP agonists to block mechanical allodynia, cold allodynia, and thermal hyperalgesia will be determined to better understand both the ability of these compounds to attenuate the hypersensitivity ..
  52. Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a Fo
    Gregory Scherrer; Fiscal Year: 2011
    ..However, current opioid therapies generate significant side effects (i.e. paradoxical hyperalgesia, drug abuse, vomiting, constipation, respiratory depression, etc) and have limited efficacy for the treatment ..
  53. Analgesics Targeting TRPA1 for Treatment of Chronic Pain
    JEFF MARK HERZ; Fiscal Year: 2011
    ..play a highly specific function in sensory nerves that transmit the sensations of pain and hyperalgesia in response to inflammation as well as nerve injury...
  54. PPAR Inhibition of Spinal Pain Transmission
    Bradley K Taylor; Fiscal Year: 2013
    ..AIM 1 will test the hypothesis that PPAR [unreadable] agonists reduce allodynia and hyperalgesia. We will use pharmacological agents and nervous system-specific PPAR [unreadable] deletion mutants to determine ..
  55. Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a Fo
    Gregory Scherrer; Fiscal Year: 2013
    ..However, current opioid therapies generate significant side effects (i.e. paradoxical hyperalgesia, drug abuse, vomiting, constipation, respiratory depression, etc) and have limited efficacy for the treatment ..
  56. Analgesic actions of adenosine A1 receptor along axonal tracts in chronic pain
    Takahiro Takano; Fiscal Year: 2013
    ..profile, we will test the hypothesis that the adenosine signaling along afferent tracts suppresses hyperalgesia, leading to a reduction of inflammatory mediators in the spinal cord;then compare the observed anti-..
  57. Glial-cytokine-neuronal interactions in the mechanisms of persistent pain
    Ke Ren; Fiscal Year: 2012
    ..The emerging literature strongly implicates a role for glia and inflammatory cytokines in the development of hyperalgesia. Through still unknown mechanisms, glia can be activated after injury and release chemical mediators that ..
  58. Mechanisms of Peripheral mGluR Modulation of Nociception
    Robert W Gereau; Fiscal Year: 2013
    ..promotes analgesia, and in fact mGlu2/3 activation appears to be an endogenous mechanism for the resolution of hyperalgesia. We have further demonstrated that enhancing this pathway by promoting epigenetic upregulation of mGlu2 ..
  59. Nerve Growth Factor Signaling in Painful Diabetic Neuropathy
    Hsinlin Thomas Cheng; Fiscal Year: 2013
    ..DNP experience lower extremity burning or "shock-like sensations" with increased sensitivity to both painful (hyperalgesia) and nonpainful stimuli (allodynia)...
  60. Control of Arthritic Pain by Inhibition of TRPA1 Activity
    JEFF MARK HERZ; Fiscal Year: 2013
    ..function on sensory nerve fiber endings in the joint that detect and transmit the sensations of pain and hyperalgesia in response to inflammation and nerve injury...
  61. Trigeminal - RVM involvement in bilateral deep tissue orofacial hyperalgesia
    Bryan Chai; Fiscal Year: 2012
    ..Unilateral complete Freund's adjuvant (CFA)-induced deep tissue inflammation leads to bilateral orofacial hyperalgesia in rats...
  62. Osteoarthritis Progression And Sensory Pathway Alterations
    Richard J Miller; Fiscal Year: 2013
    ..In this model, pain-dependent behaviors change over time, with knee hyperalgesia and mechanical allodynia presenting early on, while symptoms of ongoing pain are not apparent until 8-16 weeks ..
  63. MrgprC, A New Target for the Treatment of Neuropathic Pain
    Yun Guan; Fiscal Year: 2013
    ..in detail the effects of intrathecal administration of the two MrgprC agonists on tactile allodynia, mechanical hyperalgesia, heat hyperalgesia and spontaneous pain in rats after an L5 spinal nerve injury...
  64. Effects of Acupuncture-Induced nNOS-NO in Dorsal Medulla on Sensory Neuropathy
    Sheng Xing Ma; Fiscal Year: 2010
    ..provided by applicant): The most common forms of diabetic neuropathies are sensory dysfunctions with hyperalgesia and reduced temperature and vibration perception thresholds, which lead to very distressing and debilitating ..
  65. Sensory Plasticity During Central Neuropathic Pain Caused by Spinal Cord Injury
    Edgar T Walters; Fiscal Year: 2010
    ..in DRGs, and that this continuing SA excites central pain pathways, driving spontaneous pain, allodynia, and hyperalgesia. This hypothesis will be tested by 1) examining the effects of SCI on SA and electrophysiological properties of ..
  66. PEPTIDERGIC NEURONS IN THE SPINAL CORD
    VIRGINIA SEYBOLD; Fiscal Year: 1999
    ..goal of our research is to understand neurochemical mechanisms in the spinal cord that contribute to persistent hyperalgesia. This proposal continues our investigation of neurokinin receptors with respect to nociceptive pathways in the ..
  67. PAIN, OPIOID ANALGESIA AND BLOOD PRESSURE CONTROL
    Bradley Taylor; Fiscal Year: 2002
    ..inflammatory pain in an arthritic model and neuropathic pain in a spinal nerve ligation model is manifested by hyperalgesia that lasts days to weeks...
  68. Injury Induced Facilitated Neurogenic Inflammation
    Wade Kingery; Fiscal Year: 2006
    ..skin temperature, spontaneous protein extravasation, limb edema, periarticular osteopenia, spontaneous pain, hyperalgesia and allodynia...
  69. PERIPHERAL & CENTRAL SUBSTRATES OF PRIMARY HYPERALGESIA
    Alan Randich; Fiscal Year: 2000
    ..The common signs of inflammation include hyperalgesia, redness, swelling, and increased temperature...
  70. Spinal Matrix Metalloproteinases in Hyperalgesia and Allodynia
    CHRISTINA CHRISTIANSON; Fiscal Year: 2010
    b>Hyperalgesia- a pain response initiated by a normally non-painful stimulus is present in conditions ranging from pancreatic cancer to diabetic neuropathies...
  71. PARTIAL RHIZOTOMY EFFECTS ON SPINAL GANGLIA
    ROBERT LA MOTTE; Fiscal Year: 2002
    ..characterized by abnormal ectopic discharges (ED) and adrenergic responses in DRG neurons, and cutaneous hyperalgesia. Two hypotheses about causes of neuropathic activity are tested. 1...
  72. CENTRAL HYPERALGESIA SYSTEMS AND ANALGESIC EFFICACY
    ERIC WIERTELAK; Fiscal Year: 1999
    ..Our recent evidence suggests hyperalgesia mechanisms may increase pain sensitivity in a manner complementary to analgesia mechanism activity: 1)Just as ..