Summary: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."

Top Publications

  1. pmc Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling
    Gerard J O'Sullivan
    Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Neuropharmacology 54:1051-61. 2008
  2. pmc Kainate seizures cause acute dendritic injury and actin depolymerization in vivo
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:11604-13. 2007
  3. pmc Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats
    M A Galic
    Epilepsy and Brain Circuits Program, Hotchkiss Brain Institute, Department of Neuroscience, University of Calgary, Calgary, Alberta, Canada
    Neurobiol Dis 36:343-51. 2009
  4. pmc Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures
    Volodymyr I Dzhala
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 30:11745-61. 2010
  5. doi Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    Mattia Maroso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Nat Med 16:413-9. 2010
  6. doi Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009
    Anne T Berg
    Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
    Epilepsia 51:676-85. 2010
  7. pmc Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures
    Da Zhi Liu
    Department of Neurology and the M I N D Institute, University of California at Davis Medical Center, Sacramento, California 95817, USA
    J Cereb Blood Flow Metab 30:92-101. 2010
  8. pmc Role of oxidative stress in epileptic seizures
    Eun Joo Shin
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200 701, South Korea
    Neurochem Int 59:122-37. 2011
  9. ncbi NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
  10. ncbi Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005

Detail Information

Publications367 found, 100 shown here

  1. pmc Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling
    Gerard J O'Sullivan
    Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Neuropharmacology 54:1051-61. 2008
    ..agonist SKF 83822 [which stimulates adenylate cyclase, but not phospholipase C] induces prominent behavioral seizures in mice, whereas its benzazepine congener SKF 83959 [which stimulates phospholipase C, but not adenylate cyclase] ..
  2. pmc Kainate seizures cause acute dendritic injury and actin depolymerization in vivo
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:11604-13. 2007
    b>Seizures may cause brain injury via a variety of mechanisms, potentially contributing to cognitive deficits in epilepsy patients...
  3. pmc Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats
    M A Galic
    Epilepsy and Brain Circuits Program, Hotchkiss Brain Institute, Department of Neuroscience, University of Calgary, Calgary, Alberta, Canada
    Neurobiol Dis 36:343-51. 2009
    ..CNS and their accompanying inflammation can cause long-term neurological effects, including increased risk for seizures. To examine the effects of CNS inflammation, we infused polyinosinic:polycytidylic acid, ..
  4. pmc Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures
    Volodymyr I Dzhala
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 30:11745-61. 2010
    b>Seizures induce excitatory shifts in the reversal potential for GABA(A)-receptor-mediated responses, which may contribute to the intractability of electro-encephalographic seizures and preclude the efficacy of widely used GABAergic ..
  5. doi Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    Mattia Maroso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Nat Med 16:413-9. 2010
    ..Using models of acute and chronic seizures in C57BL/6 mice, we discovered a proconvulsant pathway involving high-mobility group box-1 (HMGB1) release from ..
  6. doi Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009
    Anne T Berg
    Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
    Epilepsia 51:676-85. 2010
    ..Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy...
  7. pmc Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures
    Da Zhi Liu
    Department of Neurology and the M I N D Institute, University of California at Davis Medical Center, Sacramento, California 95817, USA
    J Cereb Blood Flow Metab 30:92-101. 2010
    ..sham surgeries, ischemic strokes, brain hemorrhage (lysed blood, fresh blood, or thrombin), and kainate-induced seizures. Brain and whole-blood miRNA expression profiles were assessed 24 h later using TaqMan rodent miRNA arrays...
  8. pmc Role of oxidative stress in epileptic seizures
    Eun Joo Shin
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200 701, South Korea
    Neurochem Int 59:122-37. 2011
    ..However, much evidence suggests that oxidative stress does not always have the same pattern in all seizures models. Thus, this review provides an overview aimed at achieving a better understanding of this issue...
  9. ncbi NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
    ..caudal-rostral developmental pattern, GABAergic anticonvulsant compounds inhibit motor manifestations of neonatal seizures but not cortical seizure activity...
  10. ncbi Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
    ..antiinflammatory cytokines and related molecules have been described in CNS and plasma, in experimental models of seizures and in clinical cases of epilepsy...
  11. pmc Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury
    Jeanne T Paz
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA
    Nat Neurosci 16:64-70. 2013
    ..For example, epilepsy is a common sequela of cortical stroke, but the mechanisms responsible for seizures following cortical injuries remain unknown...
  12. doi A revised Racine's scale for PTZ-induced seizures in rats
    Annika Lüttjohann
    Donders Center for Cognition, FC Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Physiol Behav 98:579-86. 2009
    ..Simultaneous EEG and video recordings were made. The PTZ-induced seizures gradually increased in intensity. Eleven behavioral categories were identified and statistically analyzed...
  13. pmc Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures
    Robert J Morgan
    Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 105:6179-84. 2008
  14. pmc Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 31:2337-47. 2011
    ..status epilepticus in mice, would suppress mossy fiber sprouting and affect the development of spontaneous seizures. Mice that had experienced status epilepticus and were treated for 2 months with rapamycin displayed ..
  15. pmc Mutations in PNKP cause microcephaly, seizures and defects in DNA repair
    Jun Shen
    1 Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA 2 These authors contributed equally to the work
    Nat Genet 42:245-9. 2010
    ..describe a previously unknown autosomal recessive disease characterized by microcephaly, early-onset, intractable seizures and developmental delay (denoted MCSZ)...
  16. ncbi Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions
    Alok K Sharma
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Toxicol Pathol 35:984-99. 2007
    ..Recurrent excitation and the development of seizures have been associated with aberrant mossy fiber sprouting in the hippocampus...
  17. pmc A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors
    Susan A Masino
    Department of Psychology and Neuroscience Program, Trinity College, Hartford, Connecticut, USA
    J Clin Invest 121:2679-83. 2011
    ..Here, we have shown that KD can reduce seizures in mice by increasing activation of adenosine A1 receptors (A1Rs)...
  18. doi Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage
    Christine J Müller
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Eur J Pharmacol 619:15-24. 2009 induce a status epilepticus, which is followed by hippocampal damage and development of spontaneous recurrent seizures. In rats, pilocarpine is either administered alone or in combination with lithium, which allows a conspicuous ..
  19. ncbi Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 503 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuroscience 131:759-68. 2005
    ..Here we show that seizures can be elicited in a simple vertebrate system e.g. zebrafish larvae (Danio rerio)...
  20. pmc Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish
    Gabriela A Hortopan
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:13718-28. 2010
    ..This work may have important implications for neurological and neurodevelopmental disorders associated with mutations in ubiquitin ligase activity...
  21. pmc Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast
    Symon M Kariuki
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya, PO Box 230 Kilifi 80108, Kenya
    Brain 134:1519-28. 2011
    Falciparum malaria is an important cause of acute symptomatic seizures in children admitted to hospitals in sub-Saharan Africa, and these seizures are associated with neurological disabilities and epilepsy...
  22. pmc Long-term effect of diabetes and its treatment on cognitive function
    Alan M Jacobson
    N Engl J Med 356:1842-52. 2007
    ..Long-standing concern about the effects of type 1 diabetes on cognitive ability has increased with the use of therapies designed to bring glucose levels close to the nondiabetic range and the attendant increased risk of severe hypoglycemia...
  23. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
    ..while monocytes/macrophages were present in the hippocampus from 18 h after SE onset until chronic seizures develop, and they were found also in human TLE hippocampi...
  24. doi The role of cytokines in the pathophysiology of epilepsy
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Department of Neuroscience, Via G La Masa, 19 Milano, Italy
    Brain Behav Immun 22:797-803. 2008
    ..setting highlight the possibility that inflammatory processes in the brain contribute to the etiopathogenesis of seizures and to the establishment of a chronic epileptic focus...
  25. doi Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Seizure 20:359-68. 2011
    Animal models for seizures and epilepsy have played a fundamental role in advancing our understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have been instrumental in the discovery and preclinical development ..
  26. ncbi Why do seizures cause loss of consciousness?
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Neuroscientist 9:301-10. 2003
    ..association cortex and related subcortical structures is associated with loss of consciousness in generalized seizures. Abnormal decreased activity in these same networks may cause loss of consciousness in complex partial seizures...
  27. ncbi Psychological distress, comorbidities, and health behaviors among U.S. adults with seizures: results from the 2002 National Health Interview Survey
    Tara W Strine
    Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K 66, Atlanta, GA 30341, U S A
    Epilepsia 46:1133-9. 2005
    To examine the association of seizures with health-related quality of life (HRQOL), physical and psychiatric comorbidities, and health behaviors.
  28. ncbi A unifying explanation of primary generalized seizures through nonlinear brain modeling and bifurcation analysis
    M Breakspear
    School of Physics, University of Sydney, NSW 2006, Australia
    Cereb Cortex 16:1296-313. 2006
    ..Hence, we argue that the core electrophysiological and cognitive differences between tonic-clonic and absence seizures are predicted and interrelated by the global bifurcation diagram of the model's dynamics...
  29. pmc Seizure termination by acidosis depends on ASIC1a
    Adam E Ziemann
    Medical Scientist Training Program, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Neurosci 11:816-22. 2008
    Most seizures stop spontaneously; however, the molecular mechanisms that terminate seizures remain unknown. Observations that seizures reduced brain pH and that acidosis inhibited seizures indicate that acidosis halts epileptic activity...
  30. pmc R6/2 Huntington's disease mice develop early and progressive abnormal brain metabolism and seizures
    Efraín Cepeda-Prado
    The Robert F Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, NY 11203, USA
    J Neurosci 32:6456-67. 2012
    ..Finally, we evaluated the sensitivity of this mouse line to audiogenic seizures early in the disease course. We found that R6/2 mice had an increased susceptibility to develop seizures...
  31. pmc The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35885. 2012
    Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic children...
  32. ncbi Seizure-induced neurogenesis: are more new neurons good for an adult brain?
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48104 1687, USA
    Prog Brain Res 135:121-31. 2002
    ..neurogenic pathways in the mature brain has led to recent studies of neurogenesis in rodent models of acute seizures or epileptogenesis...
  33. pmc Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)
    K M Crowder
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:15268-73. 1999
    ..However, they fail to grow, experience severe seizures, and die within 3 weeks, suggesting multiple neural and endocrine deficits...
  34. pmc Mutations in prickle orthologs cause seizures in flies, mice, and humans
    Hirotaka Tao
    Division of Morphogenesis, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki, Japan
    Am J Hum Genet 88:138-49. 2011
    ..gene mutations have been identified, and thus far no human epilepsy gene mutations have been found to produce seizures in invertebrates...
  35. doi Early control of seizures improves long-term outcome in children with tuberous sclerosis complex
    Roberta Bombardieri
    Department of Neurosciences, Pediatric Neurology Unit, Tor Vergata University, Via Montpellier 1, Rome 00133, Italy
    Eur J Paediatr Neurol 14:146-9. 2010
    Epilepsy associated with tuberous sclerosis complex (TSC) is characterized by early onset and intractable seizures in the majority of children...
  36. pmc Interleukin-6, produced by resident cells of the central nervous system and infiltrating cells, contributes to the development of seizures following viral infection
    Jane E Libbey
    Department of Pathology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, USA
    J Virol 85:6913-22. 2011
    ..interleukin-6 (IL-6) is produced by all of these cells and has been implicated in the development of behavioral seizures in the Theiler's murine encephalomyelitis virus (TMEV)-induced seizure model...
  37. pmc Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
    M Cecilia Ljungberg
    The Cain Foundation Laboratories, Texas Children s Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Dis Model Mech 2:389-98. 2009
    ..models available that recapitulate key features of the disease, such as structural cortical abnormalities and seizures, hindering progress in understanding and treating cortical dysplasia...
  38. doi Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus
    Romain Nardou
    Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité 901, 13273 Marseille Cedex 09, France
    J Neurophysiol 101:2878-88. 2009
    ..composed of two intact interconnected hippocampi, bumetanide did not prevent generation of kainate-induced seizures, their propagation to the contralateral hippocampus, and formation of an epileptogenic mirror focus...
  39. pmc Care-seeking patterns for fatal malaria in Tanzania
    Don de Savigny
    Tanzania Essential Health Interventions Project, P O Box 78487, Dar es Salaam, Tanzania
    Malar J 3:27. 2004
    ..Although patterns of care-seeking during uncomplicated malaria episodes are well known, studies in cases of fatal malaria are rare. Care-seeking behaviours may differ between these groups...
  40. pmc Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
    Xiaoxing Huang
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Neurobiol Dis 40:193-9. 2010
    Inhibition of mTOR by rapamycin has been shown to suppress seizures in TSC/PTEN genetic models...
  41. ncbi SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release
    R Janz
    Howard Hughes Medical Institute, Center for Basic Neuroscience and Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas 75235, USA
    Neuron 24:1003-16. 1999
    ..that SV2B knockout mice are phenotypically normal while SV2A- and SV2A/SV2B double knockout mice exhibit severe seizures and die postnatally...
  42. ncbi Structural changes in patients with primary generalized tonic and clonic seizures
    Carolina Ciumas
    Department of Clinical Neuroscience, Division of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Neurology 67:683-6. 2006
    ..and voxel-based morphometry in 19 patients who had idiopathic generalized epilepsy (IGE) with tonic clonic seizures as the only seizure type and 52 control subjects...
  43. ncbi Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo
    Zita Gajda
    Department of Comparative Physiology, University of Szeged, Szeged, Hungary
    Epilepsia 46:1581-91. 2005
    ..GJ) communication via connexin 36 (Cx36) channels to epileptogenesis and to the maintenance and propagation of seizures was investigated in both the primary focus and the mirror focus by using pharmacologic approaches with the 4-..
  44. ncbi Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis
    H E Scharfman
    Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York 10993 1195, USA
    J Neurosci 20:6144-58. 2000
    ..Taken together with the recent evidence that granule cells that are born after seizures can migrate into the hilus, the results suggest that some newly born granule cells migrate as far as the CA3 cell ..
  45. ncbi Status epilepticus severity influences the long-term outcome of neurogenesis in the adult dentate gyrus
    Paul Mohapel
    Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Neurobiol Dis 15:196-205. 2004
    ..We induced seizures by applying continuous electrical stimulation to the hippocampus in adult rats to explore the effects of three ..
  46. ncbi Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:9400-7. 2007
    ..dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration ..
  47. pmc Seizure-promoting effect of blood-brain barrier disruption
    Nicola Marchi
    Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 48:732-42. 2007
    ..However, evidences also suggest that BBB failure may be an etiological factor contributing to the development of seizures.
  48. pmc The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states. II. Network and glial dynamics
    Ghanim Ullah
    Center for Neural Engineering, Department of Engineering Science and Mechanics, The Pennsylvania State University, 212 Earth Engineering Science Building, University Park, PA 16802, USA
    J Comput Neurosci 26:171-83. 2009 how the interrelated dynamics of sodium and potassium affect the excitability of neurons, the occurrence of seizures, and the stability of persistent states of activity...
  49. pmc Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus
    T Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Cell Death Dis 1:e79. 2010
    ..Experimental seizures up-regulate p53 in the brain, and acute seizure-induced neuronal death can be reduced by genetic deletion or ..
  50. ncbi Seizures accelerate functional integration of adult-generated granule cells
    Linda S Overstreet-Wadiche
    Vollum Institute, L474, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 26:4095-103. 2006
    ..In the dentate gyrus, seizures enhance adult neurogenesis, but it is unclear to what extent newborn granule cells participate in seizure-induced ..
  51. ncbi Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures
    Susanna M I Goorden
    Department of Neuroscience, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Ann Neurol 62:648-55. 2007
    ..Here, we reinvestigated the relation among cerebral lesions, epilepsy, and cognitive function using Tsc1+/- mice...
  52. doi Severe mental retardation, seizures, and hypotonia due to deletions of MEF2C
    Beata A Nowakowska
    Department of Medical Genetics, Institute of Mother and Child, Warsaw, Poland
    Am J Med Genet B Neuropsychiatr Genet 153:1042-51. 2010
    ..8 Mb deletion of TMEM161B and MEF2C was found in a child with severe developmental delay, hypotonia, and seizures. Patient 3 had epilepsy, hypotonia, thinning of the corpus callosum, and developmental delay associated with a de ..
  53. pmc Seizures and epileptiform activity in the early stages of Alzheimer disease
    Keith A Vossel
    Gladstone Institute of Neurological Disease, San Francisco, California2Memory and Aging Center, Department of Neurology, University of California, San Francisco, California
    JAMA Neurol 70:1158-66. 2013
    ..We report key features of AD-related seizures and epileptiform activity that are instructive for clinical practice and highlight similarities between AD and ..
  54. pmc Changes in the expression of GABAA receptor subunit mRNAs in parahippocampal areas after kainic acid induced seizures
    Meinrad Drexel
    Department of Pharmacology, Innsbruck Medical University Innsbruck, Austria
    Front Neural Circuits 7:142. 2013
    ..and parasubiculum, and notably the entorhinal cortex (EC) are intimately involved in the generation of limbic seizures in temporal lobe epilepsy...
  55. doi Surgical outcomes in lesional and non-lesional epilepsy: a systematic review and meta-analysis
    Jose F Tellez-Zenteno
    Department of Medicine, Division of Neurology, University of Saskatchewan, Saskatoon, Canada
    Epilepsy Res 89:310-8. 2010
    ..To provide evidence-based quantitative summary estimates of seizure outcomes in patients with non-lesional and lesional epilepsy treated with surgery, and to assess the consistency of results among published studies...
  56. pmc Seizure prediction: methods
    Paul R Carney
    Departments of Pediatrics, Neurology, Neuroscience, and Biomedical Engineering, McKnight Brain Institute, Wilder Center of Excellence for Epilepsy Research, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Epilepsy Behav 22:S94-101. 2011
    ..Although antiepileptic drugs have helped treat millions of patients, roughly a third of all patients have seizures that are refractory to pharmacological intervention...
  57. doi Osthole suppresses seizures in the mouse maximal electroshock seizure model
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Eur J Pharmacol 607:107-9. 2009
    ..It may become a novel treatment option following further investigation in other animal models of epilepsy and preclinical studies...
  58. pmc Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy
    Premysl Jiruska
    Neuronal Networks Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Neurobiol Dis 54:492-8. 2013
    ..for this increase, we examined precursor cell proliferation and neurogenesis after the onset of spontaneous seizures in a model of temporal lobe epilepsy induced by unilateral intrahippocampal injection of tetanus toxin, which ..
  59. doi Somatostatin receptor subtype 4 couples to the M-current to regulate seizures
    Cuie Qiu
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19348, USA
    J Neurosci 28:3567-76. 2008
    ..However, the most robust differences were observed in the SST(4) knock-outs. When seizures were induced by systemic injection of kainate, only SST(4) knock-outs showed an increase in seizure sensitivity...
  60. ncbi Epigenetic modulation of seizure-induced neurogenesis and cognitive decline
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:5967-75. 2007
    ..The number of newborn neurons is dynamically regulated by a variety of factors. Kainic acid-induced seizures, a rodent model of human temporal lobe epilepsy, strongly induce the proliferation of DG neurogenic progenitor ..
  61. ncbi Assessing seizure dynamics by analysing the correlation structure of multichannel intracranial EEG
    Kaspar Schindler
    Klinik für Epileptologie, Bonn, Germany
    Brain 130:65-77. 2007
    Epileptic seizures are commonly characterized as 'hypersynchronous states'. This habit is doubly misleading, because seizures are not necessarily synchronous and are not unchanging 'states' but dynamic processes...
  62. pmc Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia
    Mohamed M Helmy
    Department of Biosciences, University of Helsinki, Helsinki, Finland
    Brain 135:3311-9. 2012
    ..The mechanisms underlying birth asphyxia seizures are unknown...
  63. pmc Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304
    Jacqueline A French
    NYU Comprehensive Epilepsy Center, New York, NY, USA
    Neurology 79:589-96. 2012
    ..8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment of drug-resistant partial-onset seizures.
  64. doi Seizures in juvenile Huntington's disease: frequency and characterization in a multicenter cohort
    Leslie J Cloud
    Department of Neurology, Virginia Commonwealth University, Richmond, Virginia 23298 0539, USA
    Mov Disord 27:1797-800. 2012
    ..The primary aim of this study was to characterize the seizures in juvenile HD (JHD) subjects with regard to frequency, semiology, defining EEG characteristics, and response to ..
  65. doi Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo
    Adi Cymerblit-Sabba
    Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    J Neurosci 30:1619-30. 2010
    ..the cortical network fluctuates between the asymptomatic interictal state and the symptomatic ictal state of seizures. Despite their importance, the network dynamics responsible for the transition between the interictal and ictal ..
  66. doi Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures
    Anath C Lionel
    The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada
    Hum Mol Genet 22:2055-66. 2013
    ..of six unrelated subjects, with a range of neurodevelopmental diagnoses including ASD, schizophrenia or seizures, who possess rare de novo or inherited hemizygous microdeletions overlapping exons of GPHN at chromosome 14q23.3...
  67. pmc Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen
    Eric Lancaster
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:67-76. 2010
    ..Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved...
  68. pmc Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy
    Ramkumar Kuruba
    Department of SurgeryDuke University Medical Center, Durham, NC 27710, USA
    Epilepsy Behav 14:65-73. 2009
    ..Certain pathological stimuli such as seizures alter both the amount and the pattern of neurogenesis, though the overall effect depends on the type of seizures...
  69. pmc Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury
    Hannah C Glass
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0663, USA
    J Pediatr 155:318-23. 2009
    To examine whether neonatal seizures are associated with neurodevelopmental outcomes in infants with hypoxia-ischemia independent of the presence and severity of brain injury seen on magnetic resonance imaging (MRI).
  70. ncbi The alpha3 and beta4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice
    Ramiro Salas
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuropharmacology 47:401-7. 2004
    ..nAChRs) elicits a series of dose-dependent behaviors that go from altered exploration, sedation, and tremors, to seizures and death. nAChRs are pentameric ion channels usually composed of alpha and beta subunits...
  71. pmc Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures
    Jayne Abraham
    Department of Pediatrics, Children s Memorial Hospital, Division of Neurobiology, Children s Memorial Research Center, IL, USA
    Neurobiol Dis 46:425-30. 2012
    ..responded with greater microglial activation in response to "second hit" of KA, but shorter latency to express seizures. Inhibition of seizure-induced inflammation by 7 day minocycline post-treatment abrogated both the exaggerated ..
  72. pmc Short report: A calcified Taenia solium granuloma associated with recurrent perilesional edema causing refractory seizures: histopathological features
    Winnie W Ooi
    Department of Infectious Diseases, Lahey Clinic, Burlington, Massachusetts, USA
    Am J Trop Med Hyg 85:460-3. 2011
    ..histological description of an excised calcified Taenia solium granuloma from a patient who developed recurrent seizures associated with perilesional edema surrounding a calcified cysticercus (PEC)...
  73. pmc Mice with deficiency of G protein gamma3 are lean and have seizures
    William F Schwindinger
    Geisinger Clinic, Weis Center for Research, 100 North Academy Ave, Danville, PA 17822, USA
    Mol Cell Biol 24:7758-68. 2004
    ..Suggesting unique roles for gamma3 in the brain, Gng3-/- mice display increased susceptibility to seizures, reduced body weights, and decreased adiposity compared to their wild-type littermates...
  74. doi Circadian distribution and sleep/wake patterns of generalized seizures in children
    Marcin Zarowski
    Department of Neurology, Division of Epilepsy and Clinical Neurophysiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Epilepsia 52:1076-83. 2011
    To evaluate the relationship of sleep/awake and circadian patterns to generalized seizures.
  75. doi Altered resting state networks in epileptic patients with generalized tonic-clonic seizures
    Zhengge Wang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, 305 Eastern Zhongshan Rd, Nanjing 210002, PR China
    Brain Res 1374:134-41. 2011
    ..the functional architecture of the RSNs in idiopathic generalized epilepsy patients with generalized tonic-clonic seizures (GTCS). Resting state fMRI data were acquired from 16 GTCS patients and 16 healthy subjects...
  76. pmc A diagnostic and therapeutic scheme for a solitary cysticercus granuloma
    G Singh
    Department of Neurology, Dayanand Medical College, Ludhiana, Punjab, India
    Neurology 75:2236-45. 2010
    ..Solitary cysticercus granuloma (SCG) is one of the most common forms of presentation of neurocysticercosis (NCC). The diagnostic workup and management approach to this condition remain uncertain and controversial...
  77. doi IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Brain Behav Immun 25:1281-9. 2011
    Increasing evidence supports the involvement of immune and inflammatory processes in the etiopathogenesis of seizures. In particular, activation of innate immune mechanisms and the subsequent inflammatory responses, that are induced in ..
  78. doi Functional connectivity of dissociation in patients with psychogenic non-epileptic seizures
    Sylvie J M van der Kruijs
    Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands
    J Neurol Neurosurg Psychiatry 83:239-47. 2012
    Psychogenic non-epileptic seizures (PNES) resemble epileptic seizures, but lack epileptiform brain activity. Instead, the cause is assumed to be psychogenic...
  79. doi Effect of sildenafil on the anticonvulsant action of classical and second-generation antiepileptic drugs in maximal electroshock-induced seizures in mice
    Dorota Nieoczym
    Department of Animal Physiology, Institute of Biology, Maria Curie Skłodowska University, Lublin, Poland
    Epilepsia 51:1552-9. 2010
    The goal of the present study was to evaluate the effects of sildenafil on the threshold for electrically induced seizures in mice...
  80. pmc Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures
    Jonathan K Kleen
    Department of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Neurosci 31:15397-406. 2011
    ..activity in the hippocampus (both CA3 and CA1) and prefrontal cortex of adult rats that had experienced repeated seizures in the first weeks of life, while they were remedially trained on a delayed-nonmatch-to-sample memory task...
  81. doi The effect of seizures on working memory and executive functioning performance
    Leah Chapman Black
    Department of Psychology, University of Cincinnati, Cincinnati, OH 45221 0376, USA
    Epilepsy Behav 17:412-9. 2010 higher cognitive functions in patients with temporal lobe epilepsy (TLE) (N=207) or psychogenic nonepileptic seizures (PNES) (N=216)...
  82. doi Neurologic aspects of MECP2 gene duplication in male patients
    Bernard Echenne
    Neuropediatric Service, CHU Montpellier, Montpellier, France
    Pediatr Neurol 41:187-91. 2009
    ..Epilepsy with frequent seizures of the myoclonic-astatic type was observed in these patients and was associated with a slowing of the background ..
  83. doi Epileptic tolerance is associated with enduring neuroprotection and uncoupling of the relationship between CA3 damage, neuropeptide Y rearrangement and spontaneous seizures following intra-amygdala kainic acid-induced status epilepticus in mice
    E M Jimenez-Mateos
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Neuroscience 171:556-65. 2010
    Brief, non-harmful seizures can activate endogenous protective programmes which render the brain resistant to damage caused by prolonged seizure episodes...
  84. pmc Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice
    David M Feliciano
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Clin Invest 121:1596-607. 2011
    ..Patients with TSC suffer from intractable seizures resulting from cortical malformations known as tubers, but research into how these tubers form has been limited ..
  85. ncbi Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    S A Backman
    Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Nat Genet 29:396-403. 2001
    ..Mice homozygous for this deletion (PtenloxP/loxP;Gfap-cre), developed seizures and ataxia by 9 wk and died by 29 wk...
  86. doi Functional integration of new hippocampal neurons following insults to the adult brain is determined by characteristics of pathological environment
    James C Wood
    Laboratory of Neurogenesis and Cell Therapy, Lund University Hospital, SE 221 84 Lund, Sweden
    Exp Neurol 229:484-93. 2011 the morphology and electrophysiology of new neurons are affected by a comparably mild pathology: repetitive seizures causing hyperexcitability but not inflammation. Rats were subjected to rapid kindling, i.e...
  87. pmc Neuro-inflammation, blood-brain barrier, seizures and autism
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA
    J Neuroinflammation 8:168. 2011
    ..Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead ..
  88. doi Early seizures in intracerebral hemorrhage: incidence, associated factors, and outcome
    V De Herdt
    Universite Lille Nord de France, Neurology Department, Lille, France
    Neurology 77:1794-800. 2011
    In patients with spontaneous intracerebral hemorrhage (ICH), the occurrence of early seizures (ES) may be a prognostic marker...
  89. pmc A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice
    Satoko Tokuda
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Mol Genet 20:988-99. 2011
    ..mutagenesis screen, a novel, dominant mouse mutation, Nmf350, caused low seizure threshold, sporadic tonic-clonic seizures, brain enlargement and ectopic neurons in the dentate hilus and molecular layer of the hippocampus...
  90. pmc Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant
    Else A Tolner
    Department of Biosciences, University of Helsinki, Helsinki, Finland
    Epilepsia 52:104-14. 2011
    ..We aimed to determine whether inhaling 5% CO₂ can be used to suppress seizures in epilepsy patients...
  91. doi Neuroanatomic correlates of psychogenic nonepileptic seizures: a cortical thickness and VBM study
    Angelo Labate
    Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    Epilepsia 53:377-85. 2012
    Psychogenic nonepileptic seizures (PNES) are among the most common clinical manifestations of conversion disorder and consist of paroxysmal behavior that resembles epileptic seizures...
  92. doi Factors associated with impaired quality of life in younger and older adults with epilepsy
    Leonides Canuet
    Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Japan
    Epilepsy Res 83:58-65. 2009
    ..In summary, in younger as well as older adult epilepsy patients, depressive symptoms emerge as the strongest predictor of QoL. However, older adults appear to adapt better to their chronic health problem...
  93. doi Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine
    R M Freitas
    Laboratory of Physiology and Pharmacology, Federal University of Piaui, Piaui, Brazil
    Neurosci Lett 462:225-9. 2009
    ..and nitrite levels increased in same period in the hippocampus of animals observed during spontaneous recurrent seizures. Previous studies showed that animals presenting seizures and submitted to 24h of status epilepticus showed ..
  94. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
    ..Acute kainate-induced seizures resulted in biphasic activation of the mTOR pathway, as evident by an increase in phospho-S6 (P-S6) expression...
  95. ncbi Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy
    M E Barton
    Anticonvulsant Screening Project, Department of Pharmacology and Toxicology, University of Utah, 30 S 2000 E Room 201, Salt Lake City, UT 84112, USA
    Epilepsy Res 47:217-27. 2001
    Originally described as a model of 'psychomotor seizures' (J. Pharmacol. Exp. Ther. (1953) 107-273), the 6 Hz corneal stimulation model was abandoned shortly after its description because of its lack of sensitivity to phenytoin...
  96. doi Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice
    Nima Naderi
    Neuroscience Research Center, Shahid Beheshti University MC, Tehran, Iran
    J Neural Transm (Vienna) 115:1501-11. 2008
  97. doi Preventing and treating posttraumatic seizures: the human experience
    Nancy R Temkin
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98104 2499, USA
    Epilepsia 50:10-3. 2009
    ..common, characteristics that put people at high risk such as penetrating injury or subdural hematoma or provoked seizures are easily identified, and the latency between the injury and the onset of epileptic seizures is frequently short...
  98. ncbi Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures
    Daisuke Tsuchiya
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    Neurosurgery 53:1179-87; discussion 1187-8. 2003
    ..The effects of hsp70 overexpression were also evaluated after transient global ischemia or kainic acid (KA)-induced seizures, to verify the results in other excitotoxic stress models.
  99. pmc Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures
    Louise Parker
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720, USA
    Genetics 187:523-34. 2011
    ..As such, bss-associated seizures resemble those of pharmacologically resistant epilepsies caused by mutation of the human Na(V) SCN1A, such as ..
  100. ncbi Mitochondrial dysfunction and oxidative stress in seizure-induced neuronal cell death
    Yao Chung Chuang
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Acta Neurol Taiwan 19:3-15. 2010
    ..Prolonged seizures may result in the mitochondrial dysfunction and increased production of reactive oxygen species and nitric oxide (..
  101. ncbi Changes in the blood-brain barrier permeability and in the brain tissue trace element concentrations after single and repeated pentylenetetrazole-induced seizures in rats
    D Sahin
    Department of Physiology, Faculty of Medicine, Kocaeli University, Derince 41900 Kocaeli, Turkey
    Pharmacol Res 48:69-73. 2003
    The behaviour of brain capillary endothelium to the passage of macromolecules in single and repeated seizures conditions and its relationship to the brain trace element concentrations are the main subject of this study...

Research Grants73

  1. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2005
    Approximately 30-40% of people with epilepsy continue to have seizures during treatment with antiepileptic drugs (AED)...
  2. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..Disease/therapy</keyword;keyword>Rats</keyword;keyword>Recovery of Function</keyword;keyword>Seizures/prevention &amp;control</keyword;keyword>*Stem Cell Transplantation</keyword;keyword>Swine</..
  3. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..This overload of excitotoxic chemicals incapacitates the victim via cholinergic toxidrome, resulting in seizures, paralysis, mucous secretions, eye irritation, cardiorespiratory depression, GI distress, and eventually, death...
  4. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..with severe forms of CPT1A deficiency can present with a wide variety of symptoms, including hypoglycemia, seizures, and Reyes syndrome, which is characterized by liver dysfunction, hypoketotic hypoglycemia, and coma...
  5. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2013 the pre-clinical model, (i) commonly used treatments, including antidepressant drugs and electroconvulsive seizures, induce dynamic changes in histone acetylation, and (ii) drugs that inhibit histone deacetylases (HDACs) exhibit ..
  6. Cerebral metabolism, EEG, and sleep cycling in critically ill neonates
    Renée A Shellhaas; Fiscal Year: 2013
    ..She plans a clinical research career focused on neonatal seizures and encephalopathy...
  7. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..Advanced computation methods allow automated detection of seizures and other forms of injury that put the brain at risk...
  8. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..such as Valium and Xanax, are widely used for the treatment of anxiety, panic attacks, insomnia, agitation and seizures. BZs can cause depressing (agonist) or stimulating (inverse agonist) effects on the central nervous system by ..
  9. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..of pregnancy manifested by high blood pressure, proteinuria, and edema, sometimes with encephalopathy, seizures, and hepatic failure...
  10. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ..leading to symptoms of acute CTA poisoning including salivation, lacrimation, defecation, muscular twitching, seizures/status epilepticus and ultimately rapid death due to respiratory failure...
  11. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..Now propose to continue studying the myoclonin1/EFHC1 disease mechanisms of persisting grand mal and myoclonic seizures in JME. We will also study how important new putative epilepsy genes are in clinic based and Veterans cohort...
  12. Chromatin Modifications and Vulnerability to Glutamate Toxicity
    ALEXEI D KONDRATYEV; Fiscal Year: 2010
    ..stress, which contributes to the neurodegeneration observed following neurological insults such as ischemia and seizures, as well as contributes to neuronal death in neurodegenerative diseases (Alzheimer's, Parkinson's, etc...
  13. Prostaglandin signaling following seizures
    Jianxiong Jiang; Fiscal Year: 2013 understand how prostaglandin signaling regulates chronic brain inflammation and degeneration during and after seizures. We have pursued two major avenues of research 1) to develop small molecules that selectively modify ..
  14. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..5 million Americans and more than 50 million individuals worldwide. Seizures result from imbalances between excitatory and inhibitory inputs within the brain...
  15. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances E Jensen; Fiscal Year: 2010
    ..The Challenges and Potential Impact Epilepsy (recurrent seizures often with cognitive comorbidities) affects over 1% of the population, and has higher incidences in early life ..
  16. Preclinical testing of a novel PDK1 inhibitor for treating vestibular schwannoma
    Abraham Jacob; Fiscal Year: 2013
    ..that cause sensorineural hearing loss, balance abnormalities, tinnitus, vertigo, facial weakness, hydrocephalus, seizures, blindness, and even death...
  17. FASEB SRC on Mitochondrial Assembly &Dynamics in Health, Disease &Aging
    Antoni Barrientos; Fiscal Year: 2011
    ..results from a defect in assembly and this can lead to a myriad of clinical phenotypes ranging from ataxia, seizures, blindness, myoclonus, dystonia, deafness, and diabetes...
  18. International Symposium on Proline Metabolism and Human Health
    Donald F Becker; Fiscal Year: 2010
    ..proline metabolic genes are manifested in neurological dysfunctions such as schizophrenia, increased incidence of seizures, connective tissue diseases, premature aging, and osteopenia...
  19. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010 known to result in ketosis and has been used for the treatment of intractable epilepsy, especially where the seizures are caused by insufficient glucose transport into the brain...
  20. Therapeutic Strategies for Neonatal Hypoxic-Ischemic Encephalopathy
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2012
    ..and after birth, and that leads to long-term disabilities, such as spastic muscle control, cognitive deficits, seizures, and developmental delays...
  21. Cerebral Malaria: Mechanisms of disease and neurological salvage
    Mahalia S Desruisseaux; Fiscal Year: 2013
    ..This form of malaria is often associated with neurological sequelae including seizures, memory impairment and behavior disturbances...
  22. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..Some complications of CD include lymphoma, osteoporosis, anemia, miscarriages, seizures, vitamin deficiencies, and co-occurrence of other autoimmune diseases. No pharmacological treatment is available...
  23. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010 develop novel, mechanism-based therapies for the treatment of organophosphate (OP) nerve agent-induced seizures. OP nerve agents, such as sarin, soman and VX act by central and peripheral cholinesterase inhibition and enhance ..
  24. Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targets
    Yang Xia; Fiscal Year: 2010
    ..PE affects the mother's kidneys, liver and other vital organs and, if undetected or untreated, can lead to seizures (eclampsia), cerebral hemorrhage, failure in vital organs (i.e., kidney and heart) and death...
  25. Function and Structure Adaptations in Forebrain Development
    PAT R LEVITT; Fiscal Year: 2013
    ..manipulation of HGF-Met signaling results in alterations in cortical interneuron development, intermittent seizures, increased anxiety and reduced social behavior in mice...
  26. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    ..While KCa2 channel blockers like the bee venom apamin increase firing rates and induce seizures in rodents, KCa2 channel activators slow down neuronal firing and have therefore been proposed for the treatment ..
    Anthony Carruthers; Fiscal Year: 2012
    ..Impaired barrier transport compromises tissue function causing apoptosis, seizures, focal neurologic deficits and coma and may have genetic, endocrine and pharmacologic origins...
  28. Microdialysis Studies of Seizure-Induced Oxidative Stress
    Craig E Lunte; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The purpose of this project is to investigate the role of epileptic seizures in oxidative stress...
  29. Adipose Organ Transplant for Treatment of Maple Syrup Urine Disease
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2012
    ..accumulate in plasma and tissues, leading to progressive neurological damage, cognitive decline, vomiting, seizures, coma, and death. Standard treatment involves intensive nutritional support to lower BCAA intake...
  30. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
    Refractory seizures remain a major source of disability despite advances in surgical and pharmacological treatment of temporal lobe epilepsy. Status epilepticus (SE) causes chronic seizures in animal models...
  31. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..We will investigate how this increase of inhibitory neuropeptide will enhance the dentate gyrus filtering of incoming activity such as seizures and how this increased filtering can affect seizure-induced hippocampal damage.
  32. A Phase II Trial of Levodopa in Angelman Syndrome
    Wen Hann Tan; Fiscal Year: 2013
    ..AS is characterized by mental retardation, limited speech, seizures, abnormal movements such as tremors, and ataxic gait...
  33. Molecular and cellular mechanism of Microcephaly
    Arnold Kriegstein; Fiscal Year: 2013
    ..Patients often have a broad spectrum of neurological problems, including mental retardation, focal or generalized seizures, hyperactivity, and attention deficit disorder...
  34. Kinetics of DNA polymerase gamma upon mutation and nucleoside analog exposure
    CHRISTAL DYANE SOHL; Fiscal Year: 2013
    ..DNA pol 3 have been linked to mitochondrial diseases such as Alpers Syndrome, which is characterized by violent seizures and liver disease and causes death in early childhod, and progressive external ophthalmoplegia, an adult onset ..
  35. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013 statistically correlated with behavioral and electrographic parameters of epilepsy (frequency of spontaneous seizures) and interictal increase of hippocampal excitability determined in the afterdischarge test)...
  36. Predicting Cognitive Decline in Adults with Down Syndrome
    Ira T Lott; Fiscal Year: 2013
    ..When adults with Down syndrome develop seizures, the cognitive decline may become precipitous...
  37. New Inactivators of GABA Aminotransferase for Addiction
    Richard B Silverman; Fiscal Year: 2013
    ..marketed as a monotherapy for pediatric patients and as an adjunctive therapy for adults with refractory seizures. It was shown by positron emission tomography (PET) in primates that vigabatrin inhibits these cocaine-induced ..
  38. Development of a Human Hydrolase to Treat Cocaine Abuse and Overdose: Rat Models
    ..from a lethal dose of cocaine given up to 12 hr later, and rescued rats from overdose even after convulsive seizures commenced...
    Abdu F Azad; Fiscal Year: 2013
    ..e., seizures, respiratory and kidney failure, and persistent frontal and temporal lobe dysfunction) or death...
  40. Longitudinal Studies of Autism Spectrum Disorders: 2 to 23
    Catherine Lord; Fiscal Year: 2012
    ..a focus on relationships among adaptive skills, behavior problems, pubertal development, and adolescent onset of seizures. This data collection is still ongoing (ages are now 16-20)...
  41. Lipid Translocating Glycosyltransferases in Congenital Neurological Disease
    PETER AB ORLEAN; Fiscal Year: 2010
    ..abnormal development of the eye, the nervous, and the musculoskeletal systems, as well as muscular dystrophy and seizures. The biochemical pathways for these protein modifications involve steps in which a sugar is transferred from a ..
  42. Intracellular Targeting of Proinflammatory Pathways to Ameliorate Type 1 Diabetes
    Daniel J Moore; Fiscal Year: 2010
    ..insulin can provide a relatively normal life for the affected children and adults, the therapy poses risk for seizures, coma, and death and even compliant patients are not always protected from complications such as blindness, renal ..
  43. Oxaloacetate's Brain Effects
    Russell H Swerdlow; Fiscal Year: 2013
    ..The second is a 2003 study performed on mice, which found OAA prevented kainic acid-induced seizures, brain mtDNA degradation, and lipid peroxidation...
  44. The Role of Intracellular Metabotropic Glutamate Receptor 5 at the Synapse
    CAROLYN ANN PURGERT; Fiscal Year: 2012
    ..Dysfunction of mGluR5 is implicated in a variety of neurological problems including anxiety, seizures, addiction, learning and memory disorders, and Fragile X Syndrome (FXS)...
  45. Role of Intronic Variants Affecting Splicing in Juvenile Myoclonic Epilepsy
    Debra J Wolgemuth; Fiscal Year: 2010
    ..genes have been identified, the functions of these genes in the brain and their roles in the pathogenesis of seizures are unknown. Linkage and association analysis led us to the bromodomain-containing gene BRD2...
  46. Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest
    Alexis A Topjian; Fiscal Year: 2013 evaluate a novel approach for real-time ICU bedside seizure detection and prompt management of non-convulsive seizures in critically ill children following cardiac arrest...
  47. Excitability mechanisms of neurocardiac regulation
    ALBERT E GLASSCOCK; Fiscal Year: 2012 used to image immediate early gene expression to generate a map of autonomic brain centers activated by seizures in Kcna1-null mice...
  48. In vivo mechanisms of methamphetamine-induced neuronal necrosis
    Denson G Fujikawa; Fiscal Year: 2013
    ..electrographic seizure discharges (RESDs) produce acidophilic neurons in the same brain regions as generalized seizures. Since 57% of mice with RESDs have no behavioral evidence of seizures, EEG recording is mandatory...
    William A Catterall; Fiscal Year: 2013
    ..have developed a mouse genetic model with all the features of DS, including susceptibility to thermally induced seizures and spontaneous seizures, ataxia, circadian rhythm and sleep disorders, cognitive deficit, autistic-like features,..
  50. Excitotoxicity in Circulatory Arrest ? Brain Injury
    ..HCA is not without significant neurological sequelae which include intellectual and neuropsychomotor impairment, seizures, choreoathetosis, delayed development and stroke...
  51. Physiological mechanisms responsible for cognitive impairments in Dravet Syndrome
    Pierre Pascal Lenck-Santini; Fiscal Year: 2013
    ..Nav1.1 is highly expressed in inhibitory interneurons that, as we defend here not only explains seizures but also cognitive impairments...
  52. Calcium Signaling in a Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    ..of status epilepticus (SE) which serves as the initial insult to the CNS, a variable latent period during which seizures do not occur, and the eventual development of recurrent, spontaneous seizures of temporal lobe origin...
  53. Detection and Quantification of Neonatal Intraventricular Hemorrhage
    Michael D Weiss; Fiscal Year: 2013
    ..While some neonates exhibit clear outward signs related to IVH such as apnea, pallor, seizures and metabolic acidosis, up to 50 percent of IVHs may be clinically silent...
  54. The Role of Stress in a Genetically Predisposed Epilepsy Model
    NIKKI TAMARA SAWYER; Fiscal Year: 2013
    ..Epilepsy affects 1-2% of the population, and approximately 30% of epilepsy patients continue to suffer from seizures despite treatment with antiepileptic medications...
  55. Mechanisms of Alcohol Withdrawal
    Dwayne W Godwin; Fiscal Year: 2012
    ..withdrawal can range from mild to gross tremors, hyperactivity, confusion, hallucinations, sleep disruption and seizures. These symptoms can worsen with each withdrawal event and complicate diagnosis and treatment...
  56. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    PAGE BUCKHANNAN PENNELL; Fiscal Year: 2010
    ..3 million women of child-bearing age in the United States. Seizures during pregnancy can cause increased risks to both the mother and fetus...
  57. Granzyme a Pathway of CTL-Mediated Cell Death
    Judy Lieberman; Fiscal Year: 2010
    ..There is now evidence that this pathway may also be activated endogenously by ischemia and seizures in the brain and that mutations in the granzyme A-activated DNase TREX1 that render cells resistant to granzyme A ..
  58. Targeted screening for Taenia solium tapeworms
    SETH E O'NEAL; Fiscal Year: 2011
    ..The eggs grow into larvae which then form cysts throughout the body;cysts in the brain are responsible for 30% of seizures in the developing world...
  59. TRPV1 Channels in hippocampal neurons
    Julie A Kauer; Fiscal Year: 2010
    ..We will begin to explore the idea that TRPV1 could play a role in febrile seizures, seizures generated in young children during fever for which there is currently no effective treatment...
  60. Environmental Triggers of Eating Seizures in Nodding Syndrome
    Peter S Spencer; Fiscal Year: 2013
    ..rhythmic nodding of the head shortly after beginning to eat their local diet, a phenomenon termed "eating seizures/epilepsy"...
  61. Brain Matters 3: Values at the Crossroads of Neurology, Psychiatry, and Psycholog
    PAUL JASON FORD; Fiscal Year: 2012
    ..Special Non-Epileptic Seizure Track: Psychogenic non-epileptic seizures (PNES) constitute a major unaddressed challenge to our healthcare system...
  62. Development of a repetitive concussion traumatic brain injury model
    Michael J Whalen; Fiscal Year: 2013
    ..daily, weekly, or monthly, and in which robust and long lasting cognitive deficits are induced in the absence of seizures, loss of consciousness, and gross structural brain lesions...
  63. 2012 Iron Sulfur Enzymes Gordon Research Conference
    Markus W Ribbe; Fiscal Year: 2012
    ..clusters and proteins causes a range of rare and serious diseases, ranging from infantile lactic acidosis and seizures to Friedreich ataxia, a disease in which patients survive until early adulthood, and ISCU myopathy, in which ..
  64. Identifying neurons and circuits critical for epileptogenesis
    Istvan Mody; Fiscal Year: 2013
    ..epilepsies and is associated with significant morbidity and mortality due to recurrent and unpredictable seizures. In the civilian population, there is a good correlation between the occurrence of a neurological insult earlier ..
  65. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2004
    Focal and generalized seizures can influence autonomic nervous system (ANS) function. Flushing, sweating and piloerection are reported in some patients with simple partial seizures...
    Thomas N Ferraro; Fiscal Year: 2012
    ..common strains of inbred mice that differ robustly with respect to their susceptibility to experimentally-induced seizures, C57BL/6J (B6), which is relatively seizure resistant, and DBA/2J (D2), which is relatively seizure susceptible...
    Nancy Temkin; Fiscal Year: 2004 continues on our 20 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures...
  68. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures. However, women with epilepsy often report an increase in seizures at the time of menstruation, a condition ..
    Manoj K Patel; Fiscal Year: 2010
    ..Current treatment for patients suffering from epileptic seizures involves the suppression of these seizures with antiepileptic drugs (AEDs)...
    Robert MacDonald; Fiscal Year: 2003
    DESCRIPTION: (Verbatim from the Applicant's Abstract) While most partial and generalized seizures are relatively brief in duration, during some seizures, early termination fails and a prolonged epileptic state occurs that has been termed ..
  71. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2007
    ..NCC is recognized as a leading cause of seizures worldwide. Seizures in NCC are evoked by localized granulomatous responses to dying parasites in the brain...
  72. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    ..Because up to 30% of patients with epilepsy continue to have seizures despite appropriate treatment with antiepileptic medications, additional interventions to improve seizure control ..
  73. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2010
    ..neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...