paraplegia

Summary

Summary: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.

Top Publications

  1. pmc Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
    Susan Harkema
    Department of Neurological Surgery, Kentucky Spinal Cord Research Center, University of Louisville, KY, USA
    Lancet 377:1938-47. 2011
  2. ncbi The Spastic Paraplegia Rating Scale (SPRS): a reliable and valid measure of disease severity
    R Schule
    Hertie Institute for Clinical Brain Research and Department of Neurology, Eberhard Karls University Tubingen, Germany
    Neurology 67:430-4. 2006
  3. ncbi The temporal profile of the reaction of microglia, astrocytes, and macrophages in the delayed onset paraplegia after transient spinal cord ischemia in rabbits
    Satoshi Matsumoto
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Ube, Japan
    Anesth Analg 96:1777-84, table of contents. 2003
  4. pmc An analysis of exome sequencing for diagnostic testing of the genes associated with muscle disease and spastic paraplegia
    Cristina Dias
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Hum Mutat 33:614-26. 2012
  5. pmc Spastic paraplegia gene 7 in patients with spasticity and/or optic neuropathy
    Stephan Klebe
    INSERM, UMR_S975 CRICM, F 75013 Paris, France
    Brain 135:2980-93. 2012
  6. ncbi Primary hydatid disease of the spine: an unusual cause of progressive paraplegia. Case report and review of the literature
    S Y Bhojraj
    P D Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai, India
    J Neurosurg 91:216-8. 1999
  7. ncbi Recurrent paraplegia caused by spinal echinococcosis
    George S Sapkas
    a Orthopedic Department, Athens University Medical School, Greece
    Orthopedics 25:1087-8. 2002
  8. ncbi Lack of evidence for apoptosis as a cause of delayed onset paraplegia after spinal cord ischemia in rabbits
    Takashi Kiyoshima
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Japan
    Anesth Analg 96:839-46, table of contents. 2003
  9. ncbi Functional electrical stimulation for walking in paraplegia: 17-year follow-up of 2 cases
    Sanjeev Agarwal
    Department of Orthopaedic Surgery, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio, USA
    J Spinal Cord Med 26:86-91. 2003
  10. ncbi PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurogenetics 6:1-16. 2005

Research Grants

  1. Merrill D Benson; Fiscal Year: 2014
  2. BEATRICE JENNY KIRATLI; Fiscal Year: 2014
  3. FASEB SRC on Mitochondrial Assembly &Dynamics in Health, Disease &Aging
    Antoni Barrientos; Fiscal Year: 2011
  4. SEAN JOSEPH PITTOCK; Fiscal Year: 2014
  5. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
  6. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
  7. Michael Levin; Fiscal Year: 2016
  8. GERARDO ANDRES MORFINI; Fiscal Year: 2014
  9. Ranu Jung; Fiscal Year: 2015
  10. Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
    Marlyn Woo; Fiscal Year: 2013

Detail Information

Publications326 found, 100 shown here

  1. pmc Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
    Susan Harkema
    Department of Neurological Surgery, Kentucky Spinal Cord Research Center, University of Louisville, KY, USA
    Lancet 377:1938-47. 2011
    ....
  2. ncbi The Spastic Paraplegia Rating Scale (SPRS): a reliable and valid measure of disease severity
    R Schule
    Hertie Institute for Clinical Brain Research and Department of Neurology, Eberhard Karls University Tubingen, Germany
    Neurology 67:430-4. 2006
    To develop and evaluate a clinical Spastic Paraplegia Rating Scale (SPRS) to measure disease severity and progression.
  3. ncbi The temporal profile of the reaction of microglia, astrocytes, and macrophages in the delayed onset paraplegia after transient spinal cord ischemia in rabbits
    Satoshi Matsumoto
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Ube, Japan
    Anesth Analg 96:1777-84, table of contents. 2003
    ..of microglia, astrocytes, and macrophages are to be further determined, the results indicate that understanding functional changes of astrocytes may be important in the mechanism of delayed onset motor dysfunction including paraplegia.
  4. pmc An analysis of exome sequencing for diagnostic testing of the genes associated with muscle disease and spastic paraplegia
    Cristina Dias
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Hum Mutat 33:614-26. 2012
    ..the targeting efficiency and sequencing coverage of 88 genes associated with muscle disease (MD) and spastic paraplegia (SPG). We used three exome-capture kits on 125 individuals...
  5. pmc Spastic paraplegia gene 7 in patients with spasticity and/or optic neuropathy
    Stephan Klebe
    INSERM, UMR_S975 CRICM, F 75013 Paris, France
    Brain 135:2980-93. 2012
    Mutations in the spastic paraplegia 7 (SPG7) gene encoding paraplegin are responsible for autosomal recessive hereditary spasticity...
  6. ncbi Primary hydatid disease of the spine: an unusual cause of progressive paraplegia. Case report and review of the literature
    S Y Bhojraj
    P D Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai, India
    J Neurosurg 91:216-8. 1999
    ..Advanced imaging studies should be performed to diagnose the disease. Early decompressive surgery with stabilization of the spine, in addition to adjuvant chemotherapy, is the treatment of choice for these patients...
  7. ncbi Recurrent paraplegia caused by spinal echinococcosis
    George S Sapkas
    a Orthopedic Department, Athens University Medical School, Greece
    Orthopedics 25:1087-8. 2002
  8. ncbi Lack of evidence for apoptosis as a cause of delayed onset paraplegia after spinal cord ischemia in rabbits
    Takashi Kiyoshima
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Japan
    Anesth Analg 96:839-46, table of contents. 2003
    The mechanisms for delayed onset paraplegia after transient spinal cord ischemia are not fully understood. We investigated whether apoptotic motor neuron death is involved in its development...
  9. ncbi Functional electrical stimulation for walking in paraplegia: 17-year follow-up of 2 cases
    Sanjeev Agarwal
    Department of Orthopaedic Surgery, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio, USA
    J Spinal Cord Med 26:86-91. 2003
    To assess the safety and effectiveness of long-term use of functional electrical stimulation (FES) for exercise, standing, and walking in individuals with paraplegia, using percutaneous intramuscular wire electrodes.
  10. ncbi PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurogenetics 6:1-16. 2005
    Pelizaeus-Merzbacher disease (PMD) and its allelic disorder, spastic paraplegia type 2 (SPG2), are among the best-characterized dysmyelinating leukodystrophies of the central nervous system (CNS)...
  11. doi Progress of the treatment for extended aortic aneurysms; is the frozen elephant trunk technique the next standard in the treatment of complex aortic disease including the arch?
    Matthias Karck
    Department of Cardiac Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 33:1007-13. 2008
    ....
  12. doi Spinal epidermoid cyst with sudden onset of paraplegia
    Anusheel Munshi
    Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India
    J Cancer Res Ther 5:290-2. 2009
    ..There was a dramatic reversal of symptoms after surgery. Histopathology revealed an epidermoid cyst of the spine. On the first follow-up visit at 3 months, the child was asymptomatic...
  13. doi Factors influencing disease progression in autosomal dominant cerebellar ataxia and spastic paraplegia
    Sophie Tezenas du Montcel
    Department of Biostatistics and Medical Informatics, and Pitié Salpêtrière Charles Foix Clinical Research Unit, Hopital Pitie Salpetriere, 47 Boulevard de l Hopital, Paris, France
    Arch Neurol 69:500-8. 2012
    ..To evaluate disease progression and determine validity of clinical tools for therapeutic trials...
  14. pmc Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia
    Emily C Oates
    Institute for Neuroscience and Muscle Research, Children s Hospital at Westmead, Westmead, Sydney, NSW 2145, Australia Discipline of Paediatrics and Child Health, Faculty of Medicine, The University of Sydney, Sydney, NSW 2006, Australia
    Am J Hum Genet 92:965-73. 2013
    ..of developing anterior horn cells and shows lower-limb predominance and clinical overlap with hereditary spastic paraplegia (HSP), a lower-limb-predominant disorder of corticospinal motor neurons...
  15. ncbi Psychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: a novel neurometabolic condition responding to folinic acid substitution
    V T Ramaekers
    Division of Paediatric Neurology, Department of Paediatrics, University Hospital Aachen, Aachen, Germany
    Neuropediatrics 33:301-8. 2002
    ..The folate receptor-1 (FR 1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5-MTHF)...
  16. doi Cardiovascular disease risk and the need for prevention after paraplegia determined by conventional multifactorial risk models: the Stockholm spinal cord injury study
    Kerstin Wahman
    Department of Neurobiology, Care Sciences and Society NVS, Division of Neurorehabilitation, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    J Rehabil Med 43:237-42. 2011
    To assess the need for intervention on cardio-vascular disease risks in persons with paraplegia according to: (i) two multifactorial risk models; and (ii) these models in combination with the additional risk of overweight/obesity.
  17. ncbi The influence of the reciprocal hip joint link in the Advanced Reciprocating Gait Orthosis on standing performance in paraplegia
    G Baardman
    Roessingh Research and Development B V, Enschede, The Netherlands
    Prosthet Orthot Int 21:210-21. 1997
    ..Therefore, it is very likely that the reciprocal hip joint link in the ARGO provides a substantial and clinically relevant reduction of upper body effort required for standing under functional conditions...
  18. ncbi Coupling between "hand" primary sensorimotor cortex and lower limb muscles after ulnar nerve surgical transfer in paraplegia
    C Babiloni
    Dipartimento di Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Behav Neurosci 118:214-22. 2004
    ..Cortico-muscular and cortico-cortical coupling was estimated by electroencephalographic-electromyographic coherence and directed transfer function of a multivariate autoregressive model...
  19. ncbi Strategies to manage paraplegia risk after endovascular stent repair of descending thoracic aortic aneurysms
    Albert T Cheung
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Ann Thorac Surg 80:1280-8; discussion 1288-9. 2005
    b>Paraplegia is a recognized complication after endovascular stent repair of descending thoracic aortic aneurysms...
  20. doi Botulinum toxin type A in the healing of a chronic buttock ulcer in a patient with spastic paraplegia after spinal cord injury
    Domenico Intiso
    Department of Neuro Rehabilitation, Scientific Institute Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    J Rehabil Med 41:1100-2. 2009
    ..A new indication for botulinum toxin type A is described here, in treatment of recurrent muscular spasms that had hampered the healing of a chronic buttock ulcer in a subject with severe spastic paraplegia.
  21. ncbi Paraplegia after lumbosacral nerve root block: report of three cases
    John K Houten
    Department of Neurosurgery, New York University School of Medicine, New York, NY 10016, USA
    Spine J 2:70-5. 2002
    ..Although transient paraparesis has been described after inadvertent intrathecal injection, an immediate and lasting deficit has not been previously described as sequelae of a nerve root block...
  22. ncbi Optimization of aortic arch replacement: two-stage approach
    Hazim J Safi
    Department of Cardiothoracic and Vascular Surgery, The University of Texas at Houston Medical School, Memorial Hermann Heart and Vascular Institute, Houston, Texas 77030, USA
    Ann Thorac Surg 83:S815-8; discussion S824-31. 2007
    ....
  23. ncbi The rumpshaker mutation in spastic paraplegia
    H Kobayashi
    Nat Genet 7:351-2. 1994
  24. ncbi X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene
    M Jouet
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, UK
    Nat Genet 7:402-7. 1994
    X-linked hydrocephalus, spastic paraplegia type I and MASA syndrome are related disorders with loci in subchromosomal region Xq28...
  25. ncbi Thoracoabdominal aneurysm surgery and the risk of paraplegia: contemporary practice and future directions
    David A Zvara
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Extra Corpor Technol 34:11-7. 2002
    ..Spinal cord ischemia and the risks of paraparesis or paraplegia remain devastating complications...
  26. ncbi Upper-extremity torque production in men with paraplegia who use wheelchairs
    Brian R Kotajarvi
    Orthopedic Biomechanics Lab, Guggenheim 128, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 83:441-6. 2002
    To study maximal upper-extremity torque values and agonist/antagonist torque ratios in a sample of individuals with paraplegia and to compare these values with a sample of age-, gender-, and weight-matched able-bodied individuals.
  27. ncbi Transplantation of embryonal spinal cord nerve cells cultured on biodegradable microcarriers followed by low power laser irradiation for the treatment of traumatic paraplegia in rats
    Semion Rochkind
    Department of Neurosurgery, Tel Aviv Sourasky Medical Center, Israel
    Neurol Res 24:355-60. 2002
    ..This suggests: 1. These in vitro composite implants are a regenerative and reparative source for reconstructing the transected spinal cord. 2. Post-operative low power laser irradiation enhances axonal sprouting and spinal cord repair...
  28. ncbi Hypokinetic circulation in persons with paraplegia
    Patrick L Jacobs
    Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33101, USA
    Med Sci Sports Exerc 34:1401-7. 2002
    ..Although it has been shown that persons with paraplegia display higher values of heart rate (HR) with lower values of stroke volume (SV) during exercise, it is not ..
  29. ncbi Psychological hardiness in women with paraplegia
    Rachel A Kinder
    Department of Nursing, Western Kentucky University, 1 Big Red Way, Bowling Green, KY 42101, USA
    Rehabil Nurs 30:68-72. 2005
    ..A secondary qualitative analysis of the transcripts of eight women with paraplegia revealed three major themes related to spinal cord injury (SCI): physiological aspects of SCI, associated with ..
  30. ncbi Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia
    Ingrid K Svenson
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, P O Box 3175, Durham, NC 27710, USA
    Neurogenetics 6:135-41. 2005
    Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous diseases characterized by neuronal degeneration that is maximal at the distal ends of the longest axons of the central nervous system...
  31. ncbi Oxidised regenerated cellulose as a cause of paraplegia after thoracotomy: case report and review of the literature
    S Dogan
    Department of Neurosurgery, School of Medicine, Uludag University, Bursa, Turkey
    Spinal Cord 43:445-7. 2005
    ..Case report...
  32. ncbi Prognostic value of magnetic resonance imaging in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion: 77 cases (2000-2003)
    Daisuke Ito
    Laboratories of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Am Vet Med Assoc 227:1454-60. 2005
    To determine whether magnetic resonance imaging findings in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion were predictive of clinical outcome.
  33. ncbi The value of motor evoked potentials in reducing paraplegia during thoracoabdominal aneurysm repair
    Michael J Jacobs
    Department of Vascular Surgery, University Hospital Aachen, The Netherlands
    J Vasc Surg 43:239-46. 2006
    b>Paraplegia after thoracoabdominal aortic aneurysm (TAAA) repair mainly occurs in patients with Crawford extent I and II...
  34. pmc Sudden onset of paraplegia caused by hemorrhagic spinal epidural angiolipoma. A case report
    Ali Akhaddar
    Department of Neurosurgery, Mohammed V Military Teaching Hospital, University of King Mohammed V Souissi, Rabat, Morocco
    Eur Spine J 17:S296-8. 2008
    ..spinal epidural bleeding resulting from thoracic epidural angiolipoma who presented with hyperacute onset of paraplegia, simulating an extradural hematoma...
  35. doi Curable cause of paraplegia: spinal dural arteriovenous fistulae
    Nozar Aghakhani
    Department of Neurosurgery, Bicetre University Hospital, Le Kremlin Bicetre, France
    Stroke 39:2756-9. 2008
    ..The objective of the current study is to demonstrate that, particularly in patients with paraplegia, surgical treatment of fistula is necessary and often has a favorable outcome.
  36. doi Sporadically occurring neurologic disease: HSP genes and apparently sporadic spastic paraplegia
    John K Fink
    Neurology 71:1468-9. 2008
  37. pmc Paraplegia increased cardiac NGF content, sympathetic tonus, and the susceptibility to ischemia-induced ventricular tachycardia in conscious rats
    Heidi L Lujan
    Department of Physiology, Wayne State Univ School of Medicine, 540 E Canfield Ave, Detroit, MI 48201, USA
    Am J Physiol Heart Circ Physiol 296:H1364-72. 2009
    ..Therefore, we tested the hypothesis that paraplegia is associated with an increased cardiac NGF content, sympathetic tonus, and susceptibility to ischemia-induced ..
  38. ncbi Postural control and fear of falling in persons with low-level paraplegia
    Ligie T John
    Physiotherapy Service, Department of Physical Medicine and Rehabilitation, Christian Medical College, Vellore, India
    J Rehabil Res Dev 47:497-502. 2010
    ..Postinjury fear of falling (FOF) can affect rehabilitation potential. We quantified FOF in 15 men with paraplegia (ambulatory with bilateral knee-ankle-foot orthoses [KAFOs] and elbow crutches) in correlation with their ..
  39. doi Movement observation activates lower limb motor networks in chronic complete paraplegia
    Sabina Hotz-Boendermaker
    Spinal Cord Injury Center, Balgrist University Hospital Zurich, Zurich, Switzerland
    Neurorehabil Neural Repair 25:469-76. 2011
    ..Movement observation could perhaps be applied to functionally sustain brain motor functions when efferent motor commands and proprioceptive feedbacks are disconnected...
  40. doi Management of Marjolin's ulcer in a chronic pressure sore secondary to paraplegia: a radical surgical solution
    Neil G Fairbairn
    Department of Plastic Surgery, St Johns Hospital, Livingston, West Lothian EH54 6PP, UK
    Int Wound J 8:533-6. 2011
    ..By discussing our radical surgical solution to this problem, we aim to highlight the importance of prompt diagnosis...
  41. pmc Weight bearing through lower limbs in a standing frame with and without arm support and low-magnitude whole-body vibration in men and women with complete motor paraplegia
    Kathie A Bernhardt
    Motion Analysis Laboratory, Department of Orthopedic Surgery, College of Medicine, Mayo Clinic, Rochester, USA
    Am J Phys Med Rehabil 91:300-8. 2012
    ..was to determine the proportion of body weight borne through the lower limbs in persons with complete motor paraplegia using a standing frame, with and without the support of their arms...
  42. doi The pig model of chronic paraplegia: a challenge for experimental studies in spinal cord injury
    Mercedes Zurita
    Neuroscience Research Unit, Hospital Puerta de Hierro Majadahonda, Joaquín Rodrigo 2, 28220 Madrid, Spain
    Prog Neurobiol 97:288-303. 2012
    ..We consider the model that is described here to be feasible and useful for preliminary testing of novel therapeutic strategies aimed at regeneration of the injured spinal cord in paraplegic patients...
  43. doi Low incidence of paraplegia after thoracic endovascular aneurysm repair with proactive spinal cord protective protocols
    Joseph L Bobadilla
    Department of Surgery, Vascular and Endovascular Surgery, University of Kentucky, Lexington, KY 40536 0293, USA
    J Vasc Surg 57:1537-42. 2013
    Paraparesis and paraplegia after thoracic endovascular aneurysm repair (TEVAR) is a greatly feared complication...
  44. ncbi Effects of circuit resistance training on fitness attributes and upper-extremity pain in middle-aged men with paraplegia
    Mark S Nash
    Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA
    Arch Phys Med Rehabil 88:70-5. 2007
    To examine the effects of circuit resistance exercise (CRT) training on muscle strength, endurance, anaerobic power, and shoulder pain in middle-aged men with paraplegia.
  45. ncbi Health-related quality of life of primary caregivers of persons with paraplegia
    L Blanes
    Division of Plastic Surgery, Federal University of Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
    Spinal Cord 45:399-403. 2007
    A cross-sectional descriptive study was performed with structured questionnaires and interviews conducted with 60 primary caregivers of persons with paraplegia (T1 to S2) owing to traumatic spinal cord injury (SCI).
  46. doi Quiz page September 2008: progressive paraplegia in a long-term hemodialysis patient. Brown tumor compressing the thoracic spinal column
    Wanjun Ren
    Friendship Nephrology and Blood Purification Center, Jinan City Central Hospital, Shangdong University School of Medicine, Jinan, Shangdong, People s Republic of China
    Am J Kidney Dis 52:A37-9. 2008
  47. ncbi Pneumocephalus secondary to cerebrospinal fluid leak associated with a lumbar pressure ulcer in a man with paraplegia
    Ibrahim M Eltorai
    Division of Plastic Surgery, University of California Irvine College of Medicine, Orange, California, USA
    J Spinal Cord Med 26:262-9. 2003
    ..This article reports such a case in a man with spinal cord injury. No previously reported cases of pneumocephalus and subarachnoid-pleural fistula secondary to a pressure ulcer are known...
  48. ncbi Paraplegia caused by spinal infection after acupuncture
    M S Bang
    Department of Rehabilitation Medicine, College of Medicine, Seoul National University, Seoul, Korea
    Spinal Cord 44:258-9. 2006
    ..Case report of a 64-year-old man with psoas abscesses, epidural abscess and spondylitis after acupuncture...
  49. pmc Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial
    A Mackay-Sim
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD, Australia
    Brain 131:2376-86. 2008
    ..transplantation of olfactory ensheathing cells into the spinal cord in six patients with complete, thoracic paraplegia. We previously reported on the methods of surgery and transplantation and the safety aspects of the trial 1 year ..
  50. doi Prevention of paraplegia during thoracoabdominal aortic aneurysm repair
    C D Bicknell
    Regional Vascular Unit, St Mary s Hospital, Imperial College London, UK
    Eur J Vasc Endovasc Surg 37:654-60. 2009
    b>Paraplegia affects up to 22% of patients undergoing thoarcoabdominal aneurysm surgery, producing long-term morbidity and a significant burden to healthcare...
  51. doi Solitary plasmacytoma of the thoracic vertebra presenting with sudden paraplegia and back pain: a pathologic case report
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu Ku, Shizuoka 424 8636, Japan
    Pathol Oncol Res 17:167-9. 2011
    ..SPC of the spine is relatively rare, and SPC presenting with sudden paraplegia is very rare...
  52. doi Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages
    Tatsuhiro Nakata
    Department of Cardiothoracic Surgery and Regeneration Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Brain Res 1420:114-24. 2011
    ..The rats underwent occlusion across the descending aorta for 13min, causing paraplegia or paresis of varying severity...
  53. ncbi Cardiovascular responses during submaximal electrical stimulation-induced leg cycling in individuals with paraplegia
    Jacqui Raymond
    Rehabilitation Research Centre, The University of Sydney, NSW, Australia
    Clin Physiol Funct Imaging 22:92-8. 2002
    ..the cardiovascular responses during electrical stimulation-induced leg cycling (ES-LCE) in people with paraplegia (PARA) compared with voluntary leg cycling (VOL) at similar levels of oxygen uptake in able-bodied (AB) ..
  54. ncbi Intramedullary neurenteric cyst presenting as infantile paraplegia: a case and review
    Deepak Agrawal
    Department of Neurosurgery, C N Center, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Pediatr Neurosurg 37:93-6. 2002
    The authors report a case of a 3-month-old male child with paraplegia in whom magnetic resonance imaging (MRI) revealed a nonenhancing intramedullary cystic lesion extending from the level of D1 to D7 without any other associated anomaly...
  55. ncbi Iatrogenic paraplegia in spinal surgery
    K S Delank
    Department of Orthopaedic Surgery, University of Cologne, Joseph Stelzmannstrasse 9, 50931, Cologne, Germany
    Arch Orthop Trauma Surg 125:33-41. 2005
    b>Paraplegia as a result of a surgical spinal procedure is a rare complication. The risk cannot be precisely quantified due to the lack of current data...
  56. doi Sagittal spinal alignment in paraplegics: a new paradigm for the rehabilitation under neuromuscular electrical stimulation
    R Castro de Medeiros
    Department of Orthopaedic Surgery, School of Medicine, Campinas State University Unicamp, Campinas, Brazil
    Spinal Cord 48:251-6. 2010
    ..Radiographic analysis of sagittal spinal alignment of paraplegics in a standing position under surface neuromuscular electrical stimulation (NMES)...
  57. ncbi Shear fracture-dislocations of the thoracic and lumbar spine associated with forceful hyperextension (lumberjack paraplegia)
    F Denis
    Minnesota Spine Center, Fairview Riverside Hospital, Minneapolis
    Spine (Phila Pa 1976) 17:156-61. 1992
    ..Eleven patients had complete paraplegia, and one had incomplete paraplegia at the time of injury. Dural tears were found in six of the patients...
  58. ncbi Effect of seat cushion on dynamic stability in sitting during a reaching task in wheelchair users with paraplegia
    R Aissaoui
    Departement de Genie Mecanique, Ecole Polytechnique de Montreal, Quebec, Canada
    Arch Phys Med Rehabil 82:274-81. 2001
    To examine the effects of seat cushions on dynamic stability in sitting during a controlled reaching task by wheelchair users with paraplegia.
  59. ncbi Development of an indoor rowing machine with manual FES controller for total body exercise in paraplegia
    Rahman Davoodi
    A E Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    IEEE Trans Neural Syst Rehabil Eng 10:197-203. 2002
    ..USA) was modified for functional electrical stimulation (FES) rowing exercise in paraplegia. A new seating system provides trunk stability and constrains the leg motion to the sagittal plane...
  60. ncbi Prevention of postoperative paraplegia during thoracoabdominal aortic surgery
    Yukio Kuniyoshi
    Second Department of Surgery, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Ann Thorac Surg 76:1477-84. 2003
    ..the impact of sequential multisegmental aortic clamping accompanied by reimplantation of as many segmental arteries as possible on the prevention of postoperative paraplegia or paraparesis during thoracoabdominal aortic graft replacement.
  61. ncbi [A case of thoracic disc herniation with sudden onset paraplegia on toilet straining: case report]
    Shunsuke Yano
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    No Shinkei Geka 31:1297-301. 2003
    ..We report a case of a 78-year-old male with sudden paraplegia while straining at the toilet...
  62. ncbi Study of bacterial translocation from gut after paraplegia caused by spinal cord injury in rats
    JianWei Liu
    Department of Orthopaedic Surgery, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China
    Spine (Phila Pa 1976) 29:164-9. 2004
    ..Normal rats and paraplegic rats with and injured spinal cord were used to study bacterial translocation from gut...
  63. ncbi Upper limb pain in a national sample of veterans with paraplegia
    Ronald J Gironda
    Chronic Pain Rehabilitation Program, James A Haley Veterans Hospital, Tampa, Florida 33612, USA
    J Spinal Cord Med 27:120-7. 2004
    ..prevalence and intensity of pain and associated patient characteristics in a national sample of veterans with paraplegia. Of particular interest were upper limb (UL) pain conditions, which pose unique challenges to individuals who ..
  64. ncbi Fitness, inflammation, and the metabolic syndrome in men with paraplegia
    Patricia J Manns
    College of Health and Human Sciences, Department of Exercise and Sport Science, Oregon State University, Corvallis, OR, USA
    Arch Phys Med Rehabil 86:1176-81. 2005
    ..syndrome (high-density lipoprotein cholesterol [HDL-C], triglycerides [TG], glucose, insulin, abdominal obesity, high blood pressure), and inflammatory factors (interleukin-6 [IL-6], C-reactive protein [CRP]) in men with paraplegia.
  65. pmc Evidence for an exaggerated postprandial lipemia in chronic paraplegia
    Mark S Nash
    Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Spinal Cord Med 28:320-5. 2005
    ..The objective of this study was to compare the postprandial lipemic responses of individuals with paraplegia with those of healthy nondisabled individuals.
  66. doi Characterisation of spinal cord in a mouse model of spastic paraplegia related to abnormal axono-myelin interactions by in vivo quantitative MRI
    Wadie Ben Hassen
    Centre Auvergne d imagerie du petit animal INRA F 63122 Saint Genès Champanelle, France
    Neuroimage 46:1-9. 2009
    ..the central nervous system myelin, the proteolipoproteins (PLP1) exhibit an ascending axonopathy, named spastic paraplegia type 2...
  67. pmc Comparison of 24-hour cardiovascular and autonomic function in paraplegia, tetraplegia, and control groups: implications for cardiovascular risk
    Dwindally Rosado-Rivera
    James J Peters VAMC, Bronx, NY, Center of Excellence, USA
    J Spinal Cord Med 34:395-403. 2011
    ..Persons with spinal cord injury (SCI) represent a model of ANS dysfunction, which may affect 24-hour hemodynamics and predispose these individuals to increased cardiovascular disease risk...
  68. ncbi [Paraplegia due to adhesive arachnoiditis. A case report]
    José Guadalupe Rodríguez Luna
    Hospital de Ortopedia para Niños Dr Germán Díaz Lombardo
    Acta Ortop Mex 23:232-6. 2009
    ..cases undergoing lumbar surgery or with a history of revision surgery, and thus a second complication may occur, paraplegia, since the common symptom of arachnoiditis is persistent low back pain...
  69. ncbi Early stabilization and decompression for incomplete paraplegia due to a thoracic-level spinal cord injury
    W F Krengel
    Department of Orthopaedics, University of Washington, Harborview Medical Center, Seattle
    Spine (Phila Pa 1976) 18:2080-7. 1993
    ..Only 14 patients with incomplete thoracic level paraplegia were identified, representing 1.2% of all spinal injuries...
  70. ncbi Paraplegia due to ossification of ligamenta flava in X-linked hypophosphatemia. A case report
    C L Vera
    Medical University of South Carolina, USA
    Spine (Phila Pa 1976) 22:710-5. 1997
    ..DATA: The patient with the stigmata and chemical findings of an X-linked hypophosphatemia presented with paraplegia and multiple calcified posterior spinal thoracic lesions...
  71. ncbi Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats
    Loic Lang-Lazdunski
    Department of Thoracic Surgery, Hôpital d Instruction des Armées PercyValbonne, France
    J Vasc Surg 38:564-75. 2003
    ..Recent studies have suggested a neuroprotective effect of polyunsaturated fatty acids against cerebral ischemia. We investigated the effect of linolenic acid (LIN) in a rat model of spinal cord ischemia...
  72. ncbi Paraplegia after lumbosacral nerve root block: report of three cases
    Charles N Aprill
    Spine J 4:368-9; author reply 369-70. 2004
  73. ncbi Paraplegia due to spinal subdural hematoma as a complication of posterior fossa surgery: Case report and review of the literature
    Tufan Hicdonmez
    Department of Neurosurgery, Trakya University, Faculty of Medicine, Edirne, Turkey
    Clin Neurol Neurosurg 108:590-4. 2006
    ..On the second postoperative day, she complained of severe epigastric pain and developed a rapid onset of paraplegia with anesthesia below the thoracic 5 spinal level...
  74. ncbi Measurement of peripheral muscle resistance in rats with chronic ischemia-induced paraplegia or morphine-induced rigidity using a semi-automated computer-controlled muscle resistance meter
    Martin Marsala
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, CA 92093, USA
    J Neurotrauma 22:1348-61. 2005
    ..Ischemic paraplegia was induced in Sprague-Dawley rats by transient aortic occlusion (10 min) in combination with systemic ..
  75. pmc Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia
    Marinella Pirozzi
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    J Clin Invest 116:202-8. 2006
    ..axons is a common feature of several debilitating diseases including complicated forms of hereditary spastic paraplegia. One such form is caused by loss of the mitochondrial energy-dependent protease paraplegin...
  76. ncbi Anterior transvertebral transposition of the spinal cord for the relief of paraplegia associated with congenital cervicothoracic kyphoscoliosis. Technical note
    Emad F Shenouda
    Department of Neurosurgery, Frenchay Hospital, Bristol, United Kingdom
    J Neurosurg Spine 5:374-9. 2006
    ..temporarily arrested the neurological deterioration; however, the patient's condition then progressed to paraplegia with a partial sensory level at L-1...
  77. doi Paraplegia after extensive thoracic and thoracoabdominal aortic aneurysm repair: does critical spinal cord ischemia occur postoperatively?
    Christian D Etz
    Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Thorac Cardiovasc Surg 135:324-30. 2008
    Spinal cord injury can occur not only during extensive thoracoabdominal aneurysm repair but also postoperatively, causing delayed-onset paraplegia.
  78. doi Recovery from paraplegia after the treatment of spinal dural arteriovenous fistula: case report and review of the literature
    Ruth Prieto
    Department of Neurosurgery, Clinico San Carlos University Hospital, 28040 Madrid, Spain
    Acta Neurochir (Wien) 151:1385-97. 2009
    ..The objective of this study is to examine the final functional outcome of patients with SDAVF in grade 5 gait ALS before treatment...
  79. doi Mutation analysis of the SPG4 gene in Italian patients with pure and complicated forms of spastic paraplegia
    Angela Magariello
    Institute of Neurological Sciences, National Research Council, 87050 Mangone, Cosenza, Italy
    J Neurol Sci 288:96-100. 2010
    Mutations in the SPG4 gene are the most common causes of hereditary spastic paraplegia (HSP) accounting for up to 40% of autosomal dominant (AD) forms and 12-18% of sporadic cases...
  80. ncbi Root cause analysis of paraplegia following transforaminal epidural steroid injections: the 'unsafe' triangle
    Scott E Glaser
    Pain Specialists of Greater Chicago, Burr Ridge, IL 60527, USA
    Pain Physician 13:237-44. 2010
    ..Injury to the ARM can lead to paraplegia, independent of operator skill or adjuvant safety initiatives (digital subtraction angiography, local anesthetic ..
  81. doi Predicting the risk of paraplegia after thoracic and thoracoabdominal aneurysm repair
    Stefano Zoli
    Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann Thorac Surg 90:1237-44; discussion 1245. 2010
    ..For safer surgical and endovascular repairs, an accurate prediction of the risk of paraplegia in relation to the extent of SA sacrifice is needed.
  82. pmc Nontraumatic acute paraplegia associated with cervical disk herniation
    Chao Liu
    Department of Orthopaedics, Sir Run Run Shaw Hospital, Institute of Clinical Medicine of Zhejiang University, Hang Zhou, China
    J Spinal Cord Med 33:420-4. 2010
    Acute paraplegia is a true emergency. It is often the result of trauma but is rarely reported in association with cervical disk herniation in patients without antecedent injury.
  83. doi Walking dreams in congenital and acquired paraplegia
    Marie Thérèse Saurat
    Sleep Disorders Unit, Pitie Salpetriere Hospital, Assistance Publique Hopitaux de Paris, France
    Conscious Cogn 20:1425-32. 2011
    ..In 9/10 subjects with spinal cord injury and in 5/5 with congenital paraplegia, voluntary leg movements were reported during dream, including feelings of walking (46%), running (8...
  84. ncbi The Troyer syndrome. A recessive form of spastic paraplegia with distal muscle wasting
    H E Cross
    Arch Neurol 16:473-85. 1967
  85. ncbi Restoration of walking in paraplegia by transferring the ulnar nerve to the hip: A report on the first patient
    G A Brunelli
    Fondazione per la Ricerca Sulle Lesioni del Midollo Spinale, Ome Bs, Italy
    Microsurgery 19:223-6. 1999
    ..After many years of research in animals and after obtaining permission from the Ethical Committee of the National Health Surgery, we operated on three human beings bilaterally. The first patient is walking. Two are still recovering...
  86. ncbi Facial nerve paralysis and paraplegia as presenting symptoms of acute myeloid leukemia
    B Eser
    Departments of Hematology Oncology, Erciyes University School of Medicine, Kayseri, Turkey
    Jpn J Clin Oncol 31:86-8. 2001
    ..We present here a 17-year-old-female patient who had facial nerve paralysis and paraplegia due to granulocytic sarcoma as the presenting symptoms of acute myeloid leukemia.
  87. ncbi Delayed paraplegia after endovascular repair of abdominal aortic aneurysm
    Julie A Reid
    Vascular and Endovascular Unit, Belfast City Hospital, Belfast, Ireland
    J Vasc Surg 37:1322-3. 2003
    b>Paraplegia is rare after open repair of infrarenal abdominal aortic aneurysm, and only two cases have been reported after endovascular repair, both due to atheroembolism...
  88. ncbi The relationship between sitting stability and functional performance in patients with paraplegia
    Chiung Ling Chen
    Rehabilitation Hospital and the School of Occupational Therapy, Chung Shan Medical University, Taichung, Taiwan
    Arch Phys Med Rehabil 84:1276-81. 2003
    ....
  89. ncbi Left heart bypass during descending thoracic aortic aneurysm repair does not reduce the incidence of paraplegia
    Joseph S Coselli
    The Michael E DeBakey Department of Surgery, Division of Cardiothoracic Surgery, Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Texas, USA
    Ann Thorac Surg 77:1298-303; discussion 1303. 2004
    ..The purpose of this retrospective analysis was to determine if the use of left heart bypass (LHB) reduced the incidence of paraplegia in patients who underwent DTAA repair.
  90. ncbi Paraplegia complicating percutaneous vertebroplasty for osteoporotic vertebral fracture: case report
    Nilo M Lopes
    Serviço de Neurologia e de Neurocirurgia, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil
    Arq Neuropsiquiatr 62:879-81. 2004
    ..Few hours later she developed paraplegia with preservation of light touch and a CT scan and MRI showed epidural extravasation of polymethylmethacrylate ..
  91. ncbi The R495W mutation in SPG3A causes spastic paraplegia associated with axonal neuropathy
    Valentina Scarano
    Dipartimento di Scienze Neurologiche, Universita degli Studi di Napoli Federico II, Via Pansini 5, 80131, Napoli, Italy
    J Neurol 252:901-3. 2005
    Mutations in the SPG3A gene cause a form of pure, early-onset autosomal dominant hereditary spastic paraplegia linked to chromosome 14q...
  92. ncbi Dietary intake and nutritional status of urban community-dwelling men with paraplegia
    Kristin M Tomey
    Department of Human Nutrition, University of Illinois, Chicago, IL 60612, USA
    Arch Phys Med Rehabil 86:664-71. 2005
    ..To evaluate nutritional status, dietary intake, nutrition knowledge, and depression of healthy urban men with chronic spinal cord injury (SCI) and to compare these findings with national guidelines and data...
  93. ncbi Paraplegia as the presenting manifestation of extramedullary megakaryoblastic transformation of previously undiagnosed chronic myelogenous leukemia
    Barbara J Bryant
    Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA
    Am J Hematol 82:150-4. 2007
    ..b>Paraplegia due to a spinal cord GS is an extremely rare presentation of undiagnosed leukemia...
  94. pmc Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells
    D Cizkova
    Institute of Neurobiology, Centrum of Excellence, Slovak Academy of Science, Kosice, Soltesovej 4, Slovakia
    Neuroscience 147:546-60. 2007
    Transient spinal cord ischemia in humans can lead to the development of permanent paraplegia with prominent spasticity and rigidity...
  95. ncbi Rapidly progressive paraplegia due to an extradural lumbar meningocele mimicking a cyst. Case report
    Ingo Fiss
    Department of Neurosurgery, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Neurosurg Spine 7:75-9. 2007
    ..The authors report on a lumbar intraspinal extradural meningocele that caused incomplete paraplegia in an otherwise healthy 31-year-old man in whom magnetic resonance imaging revealed stigmata of Scheuermann ..
  96. ncbi Spinal intramedullary abscess with an epidermoid secondary to a dermal sinus
    Po Cheng Hung
    Division of Pediatric Neurology, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University, Taoyuan, Taiwan
    Pediatr Neurol 37:144-7. 2007
    ..He also manifested rapidly progressive paraplegia with urine and stool retention, and was found to have a spinal intramedullary abscess with an epidermoid as the ..
  97. pmc The relationship of shoulder pain intensity to quality of life, physical activity, and community participation in persons with paraplegia
    Dee D Gutierrez
    Pathokinesiology Laboratory, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA
    J Spinal Cord Med 30:251-5. 2007
    ..Therefore, our purpose was to identify the relationship of self-reported shoulder pain with quality of life, physical activity, and community activities in persons with paraplegia resulting from SCI.
  98. ncbi Paraplegia following elective endovascular repair of abdominal aortic aneurysm: reversal with cerebrospinal fluid drainage
    A Bajwa
    Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Eur J Vasc Endovasc Surg 35:46-8. 2008
    b>Paraplegia secondary to spinal cord ischaemia is a rare but devastating complication of abdominal aortic aneurysm repair. We report a case of paraplegia following elective endovascular repair of an infrarenal aortic aneurysm...
  99. pmc Spinal extra-dural metastasis from Merkel cell carcinoma: a rare cause of paraplegia
    Kamath Vijay
    Department of Orthopaedics and Spine Surgery, Ganga Hospital, 313, Mettupalayam Road, Coimbatore, 641 011, Tamil Nadu, India
    Eur Spine J 17:S267-70. 2008
    We report a rare case of Merkel cell carcinoma with extra-dural spinal metastasis causing paraplegia. There are only four reported cases in literature...
  100. ncbi [Leptospirosis with paraplegia and abnormal lung image]
    Takatoshi Kitazawa
    Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo
    Nihon Naika Gakkai Zasshi 97:158-60. 2008
  101. doi Six cases of SCA3/MJD patients that mimic hereditary spastic paraplegia in clinic
    Yin guang Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    J Neurol Sci 285:121-4. 2009
    ..It was reported that a few of SCA3/MJD patients showed marked spastic paraplegia with or without cerebellar ataxia, which was partially first diagnosed as hereditary spastic paraplegia (HSP) ..

Research Grants70

  1. Merrill D Benson; Fiscal Year: 2014
    ..It is also a fatal complication of chronic infectious diseases such as osteomyelitis in patients with paraplegia or quadriplegia...
  2. BEATRICE JENNY KIRATLI; Fiscal Year: 2014
    ..Healthy volunteers with tetraplegia or paraplegia, between 18 and 75 years of age, of any ethnicity and both genders will be recruited for these studies...
  3. FASEB SRC on Mitochondrial Assembly &Dynamics in Health, Disease &Aging
    Antoni Barrientos; Fiscal Year: 2011
    ..Hereditary Optic Neuropathy (LHON), Leigh's Syndrome, Charcot-Marie-Tooth Syndrome, Hereditary Spastic Paraplegia, and Friedreich's ataxia...
  4. SEAN JOSEPH PITTOCK; Fiscal Year: 2014
    ..It is characterized by recurrent episodes of optic neuritis and transverse myelitis, resulting in blindness and paraplegia in most patients, and it is frequently misdiagnosed as MS. Contrary to traditional teaching, NMO is not rare...
  5. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..occurs in a number of neurodegenerative diseases such as Primary Lateral Sclerosis, pure Hereditary Spastic Paraplegia, Kennedy's disease, Spinal Muscular Atrophy, Progressive Muscular Atrophy, and amyotrophic lateral ..
  6. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    ..ATAD1 may be a good candidate for another version of spastic paraplegia that maps in the same region of the genome...
  7. Michael Levin; Fiscal Year: 2016
    ..Specifically, there was downregulation of RNA levels of the spinal paraplegia genes (SPGs). SPGs contribute to normal neuronal function and axonal transport...
  8. GERARDO ANDRES MORFINI; Fiscal Year: 2014
    ..The ultimate goal of this project is to define disease mechanisms and identify novel therapeutic targets in HSP. ..
  9. Ranu Jung; Fiscal Year: 2015
    ..learning for computer control of functional electrical stimulation of limb movement after incomplete or complete paraplegia in people and rodents...
  10. Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
    Marlyn Woo; Fiscal Year: 2013
    ..overnight polysomnography on 26 pediatric and young adults with complete thoracic spinal cord injury (ASIA A paraplegia, age 12-25 years), earlier screened to show SDB, who will be randomized to undergo passive limb (hand) movement ..
  11. Lois S Weisman; Fiscal Year: 2015
    ..selected mutations in Fig4 lead to a form of Charcot-Marie Tooth syndrome that is early onset and causes paraplegia/quadriplegia...
  12. Treatment for Dysmyelination in PMD and SPG2
    Pamela E Knapp; Fiscal Year: 2013
    ..disorder in which the CNS can be essentially devoid of myelin, to milder forms of an allelic condition, Spastic Paraplegia 2 (SPG2). In 60% of cases, PMD is due to gene duplications that result in overproduction of PLP/DM20...
  13. Local Circuit Properties of Mouse Corticospinal Neurons
    Patrick L Sheets; Fiscal Year: 2011
    ..Neuropathology affecting primary motor cortex (M1) causes major neurological impairment including paralysis/paraplegia, epilepsy, and movement disorders including amyotrophic lateral sclerosis (ALS), a disease affecting upper motor ..
  14. MOLECULAR MECHANISMS OF AXONAL TRANSPORT
    SCOTT THOMAS BRADY; Fiscal Year: 2011
    ..reductions in FAT are sufficient to produce a distal axonopathy in diseases like hereditary spastic paraplegia and disruption of FAT are documented components of pathogenesis in other neurodegenerative diseases, including ..
  15. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy
    Everette C Burdette; Fiscal Year: 2012
    ..with or without vertebral collapse, and to spinal cord and/or nerve roots compression, commonly leading to paraplegia and quadriplegia...
  16. MARK DAVID ROSE; Fiscal Year: 2016
    ..outer membrane is related to ER fusion and mutations in this pathway have been identified in hereditary spastic paraplegia. How the inner membranes fuse is not known...
  17. Kevin C Slep; Fiscal Year: 2014
    ..dynamics result in a wide spectrum of diseases including, but not limited to neurodegeneration, spastic paraplegia and aneuploidy...
  18. Nicholas E Baker; Fiscal Year: 2015
    ..Amylotrophic Lateral Sclerosis, Huntington's Disease, Charcot-Marie Tooth Disease, hereditary spastic paraplegia SPG10, Spinocerebellar Ataxia type 5, Fronto-temporal Dementia, certain viral encephalitis syndromes, Parkinson&..
  19. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..A recent publication suggests an increased age-adjusted prevalence of hypertension in persons with paraplegia (4);another study, based on self-reported data, suggests the prevalence of hypertension is doubled among the SCI ..
  20. Concurrent Upper/Lower Extremity SCI Exercise with Stimulation
    LEE BARNETT; Fiscal Year: 2010
    ..of this Phase I project are: 1) to modify and instrument a NuStep TRS4000 for FES-exercise following complete paraplegia due to SCI;2) to develop KaiSTIM autonomous stimulation control algorithms for recumbent stepping via FES;3) to ..
  21. Biological models of molecular pathogenesis if hereditary spastic paraplegia
    Peter Hedera; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Project Summary: Hereditary spastic paraplegia (HSP) is a group of untreatable neurodegenerative disorders with axonal degeneration that causes severe disability...
  22. Fate specification of corticospinal neurons by cell autonomous signaling
    Paola Arlotta; Fiscal Year: 2013
    ..dies in neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS), Hereditary Spastic Paraplegia (HSP), and Primary Lateral Sclerosis (PLS)...
  23. SWS/NTE function in neurodegeneration and axonopathy
    Doris Kretzschmar; Fiscal Year: 2013
    ..In addition, recently described mutations in the human gene cause a hereditary spastic paraplegia called NTE--related Motor Neuron Disorder...
  24. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2012
    ..disorder, the symptoms of which include corpus callosum hypoplasia, mental retardation, adducted thumbs, spastic paraplegia, and hydrocephalus. Because of the extensive evolutionary conservation of L1CAMs, these studies in C...
  25. James A McNew; Fiscal Year: 2015
    ..This work will contribute to two very important areas of research, the pathophysiology of Hereditary Spastic Paraplegia and the general mechanism of membrane fusion...
  26. Defining the regulatory role of mitotic cyclins on Endoplasmic Reticulum reorgani
    BLAKE E RIGGS; Fiscal Year: 2013
    ..chronic diseases such as type-2 diabetes and autism, and neurodegenerative diseases such as hereditary spastic paraplegia (HSP) and Alzheimer's disease...
  27. Genetic Analysis of the Roles and Regulation of Microtubule Severing in Neurons
    Nina Tang Sherwood; Fiscal Year: 2011
    ..in the microtubule severing protein Spastin are the major cause of Autosomal Dominant Hereditary Spastic Paraplegia, a debilitating neurodegenerative disease in which the longest axon tracts of the central nervous system ..
  28. Robert T Sauer; Fiscal Year: 2016
    ..For example, mutations in the m-AAA mitochondrial protease result in hereditary spastic paraplegia. ClpXP can also promote bacterial pathogenesis and is an antibiotic target...
  29. Characterization of nucleotide-dependent structural rearrangements in atlastin
    LAURA JEAN BYRNES; Fiscal Year: 2012
    Hereditary spastic paraplegia (HSP) is a group of inherited neurological disorders that cause progressive spasticity and weakness in the lower extremities...
  30. Activation of Plp gene expression in oligodendrocytes
    Patricia A Wight; Fiscal Year: 2010
    ..with the X-linked dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) and some types of spastic paraplegia (SPG2). Dysmyelination can arise from either elevated levels of Plp1 gene expression or the lack, thereof...
  31. Pembe Hande Ozdinler; Fiscal Year: 2016
    ..neuron circuitry, and their degeneration leads to various neurodegenerative diseases such as hereditary spastic paraplegia, primary lateral sclerosis and they degenerate together with spinal motor neurons in amyotrophic lateral ..
  32. Inna Djagaeva; Fiscal Year: 2014
    ..mutant amino acid changes in KIF5A, a human Khc homolog, have been identified as causing hereditary spastic paraplegia (HSP) and Charcot-Marie-Tooth (CMT2) neurodegenerative diseases...
  33. Parkinson's Disease and Mechanisms of Fast Axonal Transport
    Ramona Pufan; Fiscal Year: 2009
    ..of Alzheimer's and Huntington's diseases as well as motor neuron diseases such as Hereditary Spastic Paraplegia and peripheral neuropathies...
  34. James M Cook; Fiscal Year: 2015
    ..It includes pain following paraplegia, hypersensitivity to non-painful stimli (allodynia), for example after surgery or during migraine attacks, ..
  35. Propulsion Mechanics Variability and Shoulder Pain in Manual Wheelchair Users
    Jacob J Sosnoff; Fiscal Year: 2012
    ..of kinetic, kinematic and temporal variability in wheelchair propulsion as a function of functional level (paraplegia vs...
  36. Envronment-Sensitive genes in motoneuron degeneration
    Teepu Siddique; Fiscal Year: 2010
    ..Mutations in the second gene, CYP7B1, are caused in corticospinal degeneration in a form of hereditary spastic paraplegia (SPG5A). PONs are antioxidant and detoxify pesticides, while CYP7B1 is inhibited by agricultural fungicides...
  37. SCI SHOULDER FUNCTION IN ASSISTIVE DEVICE GAIT
    Jacquelin Perry; Fiscal Year: 2002
    ..Four functional groups of SCI subjects (weak/strong, paraplegia/tetraplegia) will be tested...
  38. KONRAD ERNST ZINSMAIER; Fiscal Year: 2014
    ..of mitochondrial function and/or distribution can cause or intensify neuropathy, neurodegeneration, and/or paraplegia. The evolutionarily conserved mitochondrial GTPase Miro contains two Ca2+ binding domains sandwiched between Rho-..
  39. ATFS-1 mediates the coordination of mitochondrial and nuclear genome expression
    Amrita M Nargund; Fiscal Year: 2013
    ..contribute to the onset of several neurodegenerative disorders including Friedreich's ataxia, spastic paraplegia, and Parkinson's disorder as well as normal aging...
  40. Neurorobotics, modularity and function in SCI and Normal Rats
    Simon F Giszter; Fiscal Year: 2012
    ..will in future require controls of the trunk as well as the limbs for injuries of spinal cord causing paraplegia or tetraplegia. Currently there is no animal model of rehabilitation and neurorobotics of the trunk...
  41. AUTOMATED DETECTION OF GENE DUPLICATIONS OR DELETIONS
    Fatima Merchant; Fiscal Year: 2005
    ..Pressure Palsies (HNPP), (2) neurological disorders; Pelizaeus-Merzbacher Disease (PMD) and X-Linked Spastic Paraplegia (SPG2), (3) muscular wasting disorders; Duchene (DMD) and Becker Muscular Dystrophy (BMD), (4) contiguous-gene ..
  42. Stephan Zuchner; Fiscal Year: 2016
    ..We propose to study well defined relatively small Mendelian families with Hereditary Spastic Paraplegia (HSP), a disabling neurodegenerative disease...
  43. SYMPOSIUM ON HEREDITARY SPASTIC PARAPLEGIA
    John Fink; Fiscal Year: 1999
    Hereditary Spastic Paraplegia (HSP) is a group of disorders characterized by progressive lower extremity spastic weakness...
  44. Mitochondrial Assembly and Dynamics in Health and Disease
    Carla Koehler; Fiscal Year: 2009
    ..Syndrome, Deafness-Dystonia Syndrome, Barth Syndrome, Charcot-Marie-Tooth Syndrome, Hereditary Spastic Paraplegia, and Friedreich's ataxia...
  45. SCI SHOULDER FUNCTION WITH WHEELCHAIRS AND TRANSFERS
    Jacquelin Perry; Fiscal Year: 1993
    ..involved in wheelchair propulsion and body transfer by SCI patients with discriminating levels of complete paraplegia and quadriplegia...
  46. HEREDITARY SPASTIC PARAPLEGIA--CLINICAL, HISTOCHEMICAL,
    John Fink; Fiscal Year: 2001
    Hereditary Spastic Paraplegia (HSP) refers to a group of disorders characterized by progressive lower extremity spastic weakness...
  47. Development of Natural Orifice Translumenal Endoscopic Neurostimulation
    Anthony Ignagni; Fiscal Year: 2007
    ..2% (2,503) of all individuals with tetraplegia and 7.1% (748) of all individuals with paraplegia required a mechanical ventilator for pulmonary support during their initial rehabilitation admission...
  48. Hereditary Spastic Paraplegia due to SPG3A/atlastin mutation
    John Fink; Fiscal Year: 2009
    ....
  49. Predicting common protein mechanisms by the light of evolution
    ANDREW NEUWALD; Fiscal Year: 2009
    ..AAA+ ATPases are associated with hereditary spastic paraplegia and the neurologic disorders torsin dystonia, Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile ..
  50. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2007
    ..1) The first gene, spastin, is the ortholog of a human gene affected in autosomal dominant spastic paraplegia (ADSP). spastin encodes an AAA ATPase...
  51. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara J Mulroy; Fiscal Year: 2010
    ..Subjects will have complete paraplegia, be between 2 and 15 years post SCI, and free of shoulder pain measured on the Wheelchair Users Shoulder Pain ..
  52. INTERVENTIONS FOR SCI SHOULDER FUNCTION IN WHEELCHAIRS
    Sara Mulroy; Fiscal Year: 2004
    ..strengthening exercise intervention on the shoulder joint forces and muscle activity during WCP in persons with paraplegia and tetraplegia from complete SCI...
  53. BODY COMPOSITION AND NUTRITION IN SPINAL CORD INJURY
    PAUL SCHLOERB; Fiscal Year: 1991
    Knowledge of body composition changes and nutritional requirements in spinal cord trauma with paraplegia or quadriplegia is limited...
  54. AUTOMATED DETECTION OF GENE DUPLICATIONS OR DELETIONS
    Fatima Merchant; Fiscal Year: 2000
    ..Pressure Palsies (HNPP), (2) neurological disorders; Pelizaeus-Merzbacher Disease (PMD) and X-Linked Spastic Paraplegia (SPG2), (3) muscular wasting disorders; Duchene (DMD) and Becker Muscular Dystrophy (BMD), (4) contiguous-gene ..
  55. International Symposium for Hereditary Spastic Paraplegia
    John Fink; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hereditary Spastic Paraplegia (HSP) is a group of motor neuron disorders characterized by progressive lower extremity spastic weakness...
  56. PARP inhibition for thoraco-abdominal aneurysm surgery
    Andrew Salzman; Fiscal Year: 2005
    ..This surgical procedure produces profound tissue injury that may result in renal and pulmonary insufficiency, paraplegia, and mortality...
  57. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2005
    ..in the L1 gene in humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  58. Seated Postural Control with Electrical Stimulation
    ARI WILKENFELD; Fiscal Year: 2002
    This proposal concentrates on the control of seated posture and balance for individuals with low tetraplegia or paraplegia through the application of electrical stimulation...
  59. The NIPA 1 protein in spastic paraplegia and development
    ROBERT NICHOLLS; Fiscal Year: 2009
    SPG6, a hereditary spastic paraplegia, has insidiously progressive lower-extremity spasticity with degeneration of long central nervous system axons. The SPG6 locus maps to chromosome 15q11...
  60. MOLEC PATHOPHYS OF CLIN VARIATION IN SPINAL CORD DISEASE
    Eric Hoffman; Fiscal Year: 2001
    ..Our findings should have significance for the progression of inherited forms of spastic paraplegia but also more broadly for spinal cord injury and CNS homeostasis.
  61. NOVEL CELL LINES ALLEVIATE CHRONIC NEUROPATHIC PAIN
    Mary Eaton; Fiscal Year: 2001
    Painful sensations are a frequent and often chronic sequela of paraplegia and quadriplegia following partial or complete lesions of the spinal cord...
  62. The Functional analysis of the novel protein spartin.
    JOANNA BAKOWSKA; Fiscal Year: 2009
    ..provided by applicant): Troyer syndrome is a "complex" form of an autosomal recessive hereditary spastic paraplegia that results from a frameshift mutation in the spartin gene, SPG20...
  63. DEVELOPMENT OF PUSHRIM FORCE AND MEASUREMENT DEVICE
    Rory Cooper; Fiscal Year: 2000
    For many of the large population of people with paraplegia the preferred method of mobility is a manual wheelchair...
  64. A2a Adenosine Agonists as Neuroprotectants
    Robert Thompson; Fiscal Year: 2003
    ..Irreversible spinal cord injury resulting in paraplegia or paraparesis is the single most devastating complication of surgery on the thoracic and thoracoabdominal aorta...
  65. Photo-Inducible Transcriptional Regulators
    John Koh; Fiscal Year: 2007
    ..the X-linked mental retardation syndrome CRASH (Corpus callosum agenesis, Retardation, Abducted thumbs, Spastic paraplegia, Hydrocephalus)...
  66. MOLECULAR CLONING OF FAMILIAL SPASTIC PARAPLEGIA
    Eric Hoffman; Fiscal Year: 1999
    DESCRIPTION: The proposed project will map and identify genes defective in familial spastic paraplegia (FSP). Autosomal recessive, dominant, and X-linked forms of FSP exist, but only the X-linked genes have been identified...
  67. TRINUCLEOTIDE REPEATS AND NEUROLOGIC DISEASE
    Russell Margolis; Fiscal Year: 2004
    ..The P.I. hypothesizes that similar disorders, including other forms of spinocerebellar ataxia, familial spastic paraplegia, and some types of familial Parkinsonism, may also be caused by expansions of CAG/CTG repeats...