paralysis

Summary

Summary: A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)

Top Publications

  1. pmc West Nile virus-associated flaccid paralysis
    James J Sejvar
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:1021-7. 2005
  2. pmc TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
    Hans Wils
    Department of Molecular Genetics, VIB, B 2610 Antwerpen, Belgium
    Proc Natl Acad Sci U S A 107:3858-63. 2010
  3. doi Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis
    Nicola Latronico
    Department of Anaesthesia, Intensive Care, and Perioperative Medicine, Division of Neuroanaesthesia and Neurocritical Care, University of Brescia, Spedali Civili, Brescia, Italy
    Lancet Neurol 10:931-41. 2011
  4. pmc Brain-computer interfaces: communication and restoration of movement in paralysis
    Niels Birbaumer
    Institute of Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany
    J Physiol 579:621-36. 2007
  5. ncbi Neurologic complications in children with enterovirus 71 infection
    C C Huang
    Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    N Engl J Med 341:936-42. 1999
  6. pmc Restoration of grasp following paralysis through brain-controlled stimulation of muscles
    C Ethier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nature 485:368-71. 2012
  7. ncbi Clinical review: Thyrotoxic periodic paralysis: a diagnostic challenge
    Annie W C Kung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Clin Endocrinol Metab 91:2490-5. 2006
  8. pmc Antigenic diversity of enteroviruses associated with nonpolio acute flaccid paralysis, India, 2007-2009
    C Durga Rao
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    Emerg Infect Dis 18:1833-40. 2012
  9. pmc Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans
    Alexandra Vaccaro
    University of Montreal Hospital Centre, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 7:e31321. 2012
  10. pmc Characterization of the non-polio enterovirus infections associated with acute flaccid paralysis in South-Western India
    Rongala Laxmivandana
    Enteric Viruses Group, National Institute of Virology, Pune, India
    PLoS ONE 8:e61650. 2013

Detail Information

Publications357 found, 100 shown here

  1. pmc West Nile virus-associated flaccid paralysis
    James J Sejvar
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:1021-7. 2005
    The causes and frequency of acute paralysis and respiratory failure with West Nile virus (WNV) infection are incompletely understood...
  2. pmc TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
    Hans Wils
    Department of Molecular Genetics, VIB, B 2610 Antwerpen, Belgium
    Proc Natl Acad Sci U S A 107:3858-63. 2010
    ..These findings suggest that approximately 25-kDa TDP-43 CTFs are noxious to neurons by a gain of aberrant nuclear function...
  3. doi Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis
    Nicola Latronico
    Department of Anaesthesia, Intensive Care, and Perioperative Medicine, Division of Neuroanaesthesia and Neurocritical Care, University of Brescia, Spedali Civili, Brescia, Italy
    Lancet Neurol 10:931-41. 2011
    ..Control of hyperglycaemia might reduce the severity of these complications of critical illness, and early rehabilitation in the intensive care unit might improve the functional recovery and independence of patients...
  4. pmc Brain-computer interfaces: communication and restoration of movement in paralysis
    Niels Birbaumer
    Institute of Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany
    J Physiol 579:621-36. 2007
    ..on non-invasive brain-computer interfaces (BCIs) and their clinical utility for direct brain communication in paralysis and motor restoration in stroke...
  5. ncbi Neurologic complications in children with enterovirus 71 infection
    C C Huang
    Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    N Engl J Med 341:936-42. 1999
    ..The initial illness resolves but is sometimes followed by aseptic meningitis, encephalomyelitis, or even acute flaccid paralysis similar to paralytic poliomyelitis.
  6. pmc Restoration of grasp following paralysis through brain-controlled stimulation of muscles
    C Ethier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nature 485:368-71. 2012
    ..We simulated some of the effects of the paralysis caused by C5 or C6 spinal cord injury by injecting rhesus monkeys with a local anaesthetic to block the median ..
  7. ncbi Clinical review: Thyrotoxic periodic paralysis: a diagnostic challenge
    Annie W C Kung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Clin Endocrinol Metab 91:2490-5. 2006
    The aim of this article was to review the clinical presentation, pathogenesis, and management of thyrotoxic periodic paralysis (TPP).
  8. pmc Antigenic diversity of enteroviruses associated with nonpolio acute flaccid paralysis, India, 2007-2009
    C Durga Rao
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    Emerg Infect Dis 18:1833-40. 2012
    Because of the broadened acute flacid paralysis (AFP) definition and enhanced surveillance, many nonpolio AFP (NP-AFP) cases have been reported in India since 2005...
  9. pmc Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans
    Alexandra Vaccaro
    University of Montreal Hospital Centre, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 7:e31321. 2012
    ..worms expressing mutant TDP-43 and FUS display adult-onset, age-dependent loss of motility, progressive paralysis and neuronal degeneration that is distinct from wild type alleles...
  10. pmc Characterization of the non-polio enterovirus infections associated with acute flaccid paralysis in South-Western India
    Rongala Laxmivandana
    Enteric Viruses Group, National Institute of Virology, Pune, India
    PLoS ONE 8:e61650. 2013
    Non-polio enteroviruses (NPEVs) have been reported frequently in association with acute flaccid paralysis (AFP) cases during Polio Surveillance Programs (PSPs) worldwide...
  11. doi Brain-computer interface in paralysis
    Niels Birbaumer
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, Tuebingen, Germany
    Curr Opin Neurol 21:634-8. 2008
    Communication with patients suffering from locked-in syndrome and other forms of paralysis is an unsolved challenge...
  12. pmc Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans
    Claudia A Angeli
    1 Frazier Rehab Institute, Kentucky One Health, Louisville, KY, USA
    Brain 137:1394-409. 2014
    ..was the key to recovery of intentional movement in four of four individuals diagnosed as having complete paralysis of the legs...
  13. ncbi Infectious causes of acute flaccid paralysis
    Tom Solomon
    Department of Neurological Science, and Medical Microbiology, University of Liverpool, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Curr Opin Infect Dis 16:375-81. 2003
    Although acute flaccid paralysis (AFP) is more frequently seen in the tropics than in temperate regions, recent outbreaks of West Nile virus (WNV) in North America have drawn attention to this important presentation...
  14. pmc Gamma interferon (IFN-γ) receptor restricts systemic dengue virus replication and prevents paralysis in IFN-α/β receptor-deficient mice
    Tyler R Prestwood
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    J Virol 86:12561-70. 2012
    ..reported that mice lacking alpha/beta and gamma interferon receptors (IFN-α/βR and -γR) uniformly exhibit paralysis following infection with the dengue virus (DENV) clinical isolate PL046, while only a subset of mice lacking the ..
  15. doi Motor inhibition in hysterical conversion paralysis
    Yann Cojan
    Department of Neuroscience, University Medical School, University of Geneva, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Neuroimage 47:1026-37. 2009
    ..To assess motor and inhibitory brain circuits during conversion paralysis, we designed a go-nogo task while a patient underwent functional magnetic resonance imaging (fMRI)...
  16. ncbi Burkholderia pseudomallei kills the nematode Caenorhabditis elegans using an endotoxin-mediated paralysis
    E M Wiegand
    Bacteriology Division, United States Army Medical Research Institute of Infectious Disease, 1425 Porter St, Fort Detrick, MD 21702-5011, USA
    Cell Microbiol 3:381-93. 2001
    ..The results of this investigation suggest that killing by B. pseudomallei is an active process in C. elegans, and that the C. elegans model might be useful for the identification of vertebrate animal virulence factors in B. pseudomallei...
  17. ncbi Paralysis of CD4(+)CD25(+) regulatory T cell response in chronic autoimmune encephalomyelitis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neuroimmunol 187:44-54. 2007
    ..These findings suggest that impairment of the CD4(+)CD25(+) Treg response is critical for development of chronic autoimmune diseases, and can be adjustable by autologous Treg transplantation...
  18. ncbi Acute flaccid paralysis: the spectrum of a newly recognized complication of West Nile virus infection
    Mustafa Saad
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Medical Service, James H Quillen VAMC, Mountainhome, Box 70622, Johnson City, TN 37614, USA
    J Infect 51:120-7. 2005
    Acute flaccid paralysis (AFP) has recently emerged as a major central nervous system complication associated with West Nile virus (WNV) infection...
  19. ncbi Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP
    V Monica Bricelj
    Institute for Marine Biosciences, National Research Council, Halifax, Nova Scotia B3H 3Z1, Canada
    Nature 434:763-7. 2005
    ..Furthermore, global expansion of PSP to previously unaffected coastal areas might result in long-term changes to communities and ecosystems...
  20. doi The Acute bee paralysis virus-Kashmir bee virus-Israeli acute paralysis virus complex
    Joachim R de Miranda
    Department of Ecology, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden
    J Invertebr Pathol 103:S30-47. 2010
    Acute bee paralysis virus (ABPV), Kashmir bee virus (KBV) and Israeli acute paralysis virus (IAPV) are part of a complex of closely related viruses from the Family Dicistroviridae...
  21. ncbi Scalp electrical recording during paralysis: quantitative evidence that EEG frequencies above 20 Hz are contaminated by EMG
    Emma M Whitham
    Department of Neurology, Flinders University and Medical Centre, GPO Box 2100, Adelaide, SA 5042, Australia
    Clin Neurophysiol 118:1877-88. 2007
    ..To identify the possible contribution of electromyogram (EMG) to scalp electroencephalogram (EEG) rhythms at rest and induced or evoked by cognitive tasks...
  22. ncbi Recovery and prognosticators of paralysis in West Nile virus infection
    Nancy Jingyang Cao
    Department of Neurology, Wayne State University School of Medicine, 4201 St Antoine, Detroit, MI 48201, USA
    J Neurol Sci 236:73-80. 2005
    ..have demonstrated that lesions of the anterior horn motor neurons are the primary pathology in patients with paralysis due to West Nile virus (WNV) infection...
  23. ncbi Instant neural control of a movement signal
    Mijail D Serruya
    Department of Neuroscience, Box 1953, Brown University, Providence, Rhode Island 02912, USA
    Nature 416:141-2. 2002
    ..Our results, which are based on recordings made by an electrode array that is suitable for human use, indicate that neurally based control of movement may eventually be feasible in paralysed humans...
  24. ncbi The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis
    P Pavlidis
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 79:23-33. 1994
    ..recordings from flight muscles in the giant fiber pathway of adult eas flies reveal that induction of paralysis with electrical stimulation results in a brief seizure, followed by a failure of the muscles to respond to giant ..
  25. doi Non-polio enteroviruses in acute flaccid paralysis children of India: vital assessment before polio eradication
    Tapan N Dhole
    Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    J Paediatr Child Health 45:409-13. 2009
    ..Wild polio cases declined because of intensive oral polio vaccine immunization. As we approach global eradication of poliovirus (PV), NPEV causing acute flaccid paralysis (AFP) are equal cause of concern.
  26. pmc Ipsilesional trajectory control is related to contralesional arm paralysis after left hemisphere damage
    Kathleen Y Haaland
    Research Service 151, New Mexico Veterans Affairs Healthcare System, Albuquerque, NM 87108, USA
    Exp Brain Res 196:195-204. 2009
    ....
  27. ncbi Relationship between the duration of paralysis and bone structure: a pQCT study of spinal cord injured individuals
    P Eser
    Institute for Clinical Research, Swiss Paraplegic Centre, 6207 Nottwil, Switzerland
    Bone 34:869-80. 2004
    ..Eighty-nine motor complete spinal cord injured men (24 tetraplegics and 65 paraplegics) with a duration of paralysis of between 2 months and 50 years were included in the study...
  28. pmc Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways
    Young Beob Yu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9339. 2010
    ..This issue may be addressed through the use of contemporary methodology and validated animal models...
  29. doi Effects of neurofeedback training with an electroencephalogram-based brain-computer interface for hand paralysis in patients with chronic stroke: a preliminary case series study
    Keiichiro Shindo
    Department of Rehabilitation Medicine, Keio University Tsukigase Rehabilitation Center, 380 2 Tsukigase
    J Rehabil Med 43:951-7. 2011
    To explore the effectiveness of neurorehabilitative training using an electroencephalogram-based brain- computer interface for hand paralysis following stroke.
  30. doi Brain correlates of hypnotic paralysis-a resting-state fMRI study
    M Pyka
    Section BrainImaging, Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
    Neuroimage 56:2173-82. 2011
    Hypnotic paralysis has been used since the times of Charcot to study altered states of consciousness; however, the underlying neurobiological correlates are poorly understood...
  31. ncbi Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants
    Elaine R Reynolds
    Department of Biology, Lafayette College, Easton, Pennsylvania 18042, USA
    J Neurobiol 58:503-13. 2004
    Drosophila bang-sensitive (bs) mutants exhibit a stereotypic seizure and paralysis following exposure to mechanical shock...
  32. ncbi New enteroviruses, EV-93 and EV-94, associated with acute flaccid paralysis in the Democratic Republic of the Congo
    Nina Junttila
    Swedish Institute for Infectious Disease Control, Solna, Sweden
    J Med Virol 79:393-400. 2007
    Surveillance of acute flaccid paralysis often identifies enteroviruses not typeable by virus neutralization in cell culture...
  33. ncbi Envenoming bites by kraits: the biological basis of treatment-resistant neuromuscular paralysis
    S Prasarnpun
    School of Neurology, Neurobiology and Psychiatry, Faculty of Medical Sciences, University of Newcastle upon Tyne, UK
    Brain 128:2987-96. 2005
    ..The inoculated hind limb was paralysed within 3 h, and remained paralysed for 2 days. The paralysis was associated with the loss of synaptic vesicles from motor nerve terminal boutons, a decline in ..
  34. pmc Toward the restoration of hand use to a paralyzed monkey: brain-controlled functional electrical stimulation of forearm muscles
    Eric A Pohlmeyer
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    PLoS ONE 4:e5924. 2009
    ..this cortically controlled FES system to control the contraction of four forearm muscles despite temporary limb paralysis. The amount of wrist force the monkeys were able to produce in a one-dimensional force tracking task was ..
  35. pmc IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    Mark A Kroenke
    Department of Neurology, Holtom Garrett Program in Neuroimmunology, University of Michigan, Ann Arbor, MI 48109, USA
    J Exp Med 205:1535-41. 2008
    ..transfer of either IL-12p70- or IL-23-polarized T cells into naive syngeneic hosts resulted in an ascending paralysis that was clinically indistinguishable between the two groups...
  36. doi Detection of Chronic bee paralysis virus (CBPV) genome and its replicative RNA form in various hosts and possible ways of spread
    Olivier Celle
    Agence Francaise de Securite Sanitaire des Aliments, Les Templiers, Route des Chappes, BP 111, Sophia Antipolis 06902, France
    Virus Res 133:280-4. 2008
    Detection of Chronic bee paralysis virus (CBPV) is reported for the first time in two species of ants (Camponotus vagus and Formica rufa) and in Varroa destructor...
  37. doi First detection of enterovirus 71 from an acute flaccid paralysis case with residual paralysis in Iran
    Shohreh Shahmahmoodi
    Pathobiology Department, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Virol 42:409-11. 2008
    In an attempt to determine the types of non-polio enteroviruses (NPEVs) in acute flaccid paralysis (AFP) cases in Iran, we detected enterovirus 71 (EV71) in an AFP case with residual paralysis for the first time...
  38. pmc Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans
    Astrid Gutierrez-Zepeda
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA
    BMC Neurosci 6:54. 2005
    ..elegans, that express human beta amyloid (Abeta), were fed with soy derived isoflavones genistein, daidzein and glycitein (100 microg/ml) and then examined for Abeta-induced paralysis and the levels of reactive oxygen species.
  39. pmc West Nile Virus-associated flaccid paralysis outcome
    James J Sejvar
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 12:514-6. 2006
    ..1-year follow-up data from a longitudinal prospective cohort study of patients with West Nile virus-associated paralysis. As in the 4-month follow-up, a variety of recovery patterns were observed, but persistent weakness was frequent...
  40. pmc RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis
    Gao Sun
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK
    Dis Model Mech 4:193-202. 2011
    ..We thus define LKB1 as an intrinsic suppressor of axon degeneration and a possible target for strategies that can reverse this process...
  41. pmc HCO(3)(-)-independent conductance with a mutant Na(+)/HCO(3)(-) cotransporter (SLC4A4) in a case of proximal renal tubular acidosis with hypokalaemic paralysis
    Mark D Parker
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Physiol 590:2009-34. 2012
    ..usually associated with defective HCO(3)(−) reabsorption in proximal tubule cells) and hypokalaemic periodic paralysis (hypoPP; usually associated with leaky cation channels in muscle cells)...
  42. doi Furious and paralytic rabies of canine origin: neuroimaging with virological and cytokine studies
    Jiraporn Laothamatas
    Department of Radiology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    J Neurovirol 14:119-29. 2008
    ..Paralytic rabies is characterized by delayed viral neuroinvasion and a more intense inflammation than furious rabies. Dogs may be a good model for study of the host inflammatory responses that may modulate rabies virus neuroinvasiveness...
  43. ncbi Quantification of fingertip force reduction in the forefinger following simulated paralysis of extensor and intrinsic muscles
    F J Valero-Cuevas
    Rehabilitation Research and Development Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    J Biomech 33:1601-9. 2000
    ..We quantified the reduction in fingertip force that can be biomechanically attributed to paralysis of the groups of muscles associated with low radial and ulnar palsies...
  44. ncbi Polio programme: let us declare victory and move on
    Neetu Vashisht
    Department of Paediatrics, St Stephens Hospital, Delhi 110054, India
    Indian J Med Ethics 9:114-7. 2012
    ..while India has been polio-free for a year, there has been a huge increase in non-polio acute flaccid paralysis (NPAFP). In 2011, there were an extra 47,500 new cases of NPAFP...
  45. ncbi Hysterical paralysis: a report of three cases and a review of the literature
    Eric J Letonoff
    St John s Hospital, Madison Heights, Michigan, USA
    Spine (Phila Pa 1976) 27:E441-5. 2002
    Three cases of hysterical paralysis are reported and the literature is reviewed.
  46. doi Analytic review: thyrotoxic periodic paralysis: a review
    Pooja Pothiwala
    Department of Medicine, Section of Endocrinology and Metabolism, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
    J Intensive Care Med 25:71-7. 2010
    Thyrotoxic periodic paralysis (TPP) is an unusual complication of hyperthyroidism that frequently presents in a dramatic fashion, necessitating treatment in an emergency department or admission to an intensive care unit...
  47. ncbi Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes
    Changjong Moon
    Department of Veterinary Medicine, Aradong 1, Cheju National University, Jeju 690 756, South Korea
    Brain Res 1035:206-10. 2005
    ..Oral phenidone (200 mg/kg) significantly suppressed the incidence and clinical severity of EAE paralysis. Western blot analysis showed that phenidone significantly inhibited the increases in COX-1/-2 and 5-LOX in the ..
  48. doi Psychogenic paralysis and recovery after motor cortex transcranial magnetic stimulation
    Nathalie Chastan
    Department of Neurophysiology, Rouen University Hospital, Rouen, France
    Mov Disord 25:1501-4. 2010
    Psychogenic paralysis presents a real treatment challenge. Despite psychotherapy, physiotherapy, antidepressants, acupuncture, or hypnosis, the outcome is not always satisfactory with persistent symptoms after long-term follow-up...
  49. doi Conversion paralysis after surgery for lumbar disc herniation
    Ming Kai Hsieh
    Department of Orthopaedic Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    Spine (Phila Pa 1976) 35:E308-10. 2010
    ..New neurologic deficit after spinal surgery is a rare complication that must be promptly diagnosed and treated to reduce the risk of permanent neurologic disability...
  50. ncbi Poliomyelitis due to West Nile virus
    Jonathan D Glass
    N Engl J Med 347:1280-1. 2002
  51. ncbi Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of action
    Bertrand Debaene
    Department of Anesthesia and Intensive Care, Hopital Jean Bernard, Poitiers, France
    Anesthesiology 98:1042-8. 2003
    ..The train-of-four (TOF) ratio at the adductor pollicis required to avoid residual paralysis is now considered to be at least 0.9...
  52. ncbi Adenosine A2A agonist reduces paralysis after spinal cord ischemia: correlation with A2A receptor expression on motor neurons
    David C Cassada
    Division of Vascular and Endovascular Surgery, University of Tennessee Medical Center, Knoxville, USA
    Ann Thorac Surg 74:846-9; discussion 849-50. 2002
    The adenosine A2A agonist ATL-146e ameliorates reperfusion inflammation, reducing subsequent paralysis and neuronal apoptosis after spinal cord ischemia...
  53. ncbi Acute flaccid paralysis: a five-year review of cases managed by physiotherapy at the University College Hospital, Ibadan
    Tal hatu K Hamzat
    Department of Physiotherapy, College of Medicine, University College Hospital, Ibadan, Nigeria
    Afr J Health Sci 13:28-32. 2006
    A 5-year (1999-2004) review of acute flaccid paralysis (AFP) cases managed at the physiotherapy clinic of the University College Hospital, Ibadan Nigeria was carried out...
  54. doi Coping strategies and IQ in psychogenic movement disorders and paralysis
    M van Beilen
    Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands
    Mov Disord 24:922-5. 2009
    ..Low active coping is not the result of low IQ and is not specific for psychogenic symptoms. At least part of the lower coping skills reported in patients with psychogenic symptoms may be the result of having an illness in general...
  55. doi Altered connectivity between prefrontal and sensorimotor cortex in conversion paralysis
    Floris P de Lange
    Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Kapittelweg 29, 6500 HB Nijmegen, Netherlands
    Neuropsychologia 48:1782-8. 2010
    Conversion paralysis (CP) is a frequent and impairing psychiatric disorder, affecting voluntary motor function...
  56. ncbi Deaths in children during an outbreak of hand, foot and mouth disease in Peninsular Malaysia--clinical and pathological characteristics
    K Shekhar
    University of Malaya, Kuala Lumpur
    Med J Malaysia 60:297-304. 2005
    ....
  57. pmc Direct control of paralysed muscles by cortical neurons
    Chet T Moritz
    Department of Physiology and Biophysics and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Nature 456:639-42. 2008
    A potential treatment for paralysis resulting from spinal cord injury is to route control signals from the brain around the injury by artificial connections...
  58. pmc Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    Silvestre Alavez
    Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, California 94945, USA
    Nature 472:226-9. 2011
    ..Our results demonstrate that pharmacological maintenance of the protein homeostatic network has a profound impact on ageing rates, prompting the development of novel therapeutic interventions against ageing and age-related diseases...
  59. doi Chronic bee paralysis: a disease and a virus like no other?
    Magali Ribière
    French Food Safety Agency Afssa, Bee Disease Unit, Les Templiers, Route des Chappes, BP 111, 06902 Sophia Antipolis, France
    J Invertebr Pathol 103:S120-31. 2010
    Chronic bee paralysis which was called Paralysis is a rather unusual disease caused by a rather unusual virus. In this review, we explore current knowledge of the disease and its etiological agent...
  60. ncbi West Nile virus infection: a new acute paralytic illness
    L E Jeha
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    Neurology 61:55-9. 2003
    ..To determine the clinical, laboratory, electrodiagnostic, radiologic, and pathologic characteristics that define the spectrum of CNS disease caused by West Nile virus (WNV) infection...
  61. ncbi Hyperactive action monitoring during motor-initiation in conversion paralysis: an event-related potential study
    Karin Roelofs
    Section Clinical and Health Psychology, University of Leiden, P O Box 9555, 2300 RB Leiden, The Netherlands
    Biol Psychol 71:316-25. 2006
    Conversion paralysis (CP) is featured by a stress-induced tonic immobility...
  62. pmc Isolation of an intertypic poliovirus capsid recombinant from a child with vaccine-associated paralytic poliomyelitis
    Javier Martin
    Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom
    J Virol 76:10921-8. 2002
    ....
  63. pmc West Nile virus-induced acute flaccid paralysis is prevented by monoclonal antibody treatment when administered after infection of spinal cord neurons
    John D Morrey
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah 84322 4700, USA
    J Neurovirol 14:152-63. 2008
    Acute flaccid polio-like paralysis occurs during natural West Nile virus (WNV) infection in a subset of cases in animals and humans...
  64. pmc Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicity
    Vishantie Dostal
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Genetics 186:857-66. 2010
    ..These results suggest that the reported protective effects of coffee in multiple neurodegenerative diseases may result from a general activation of the Nrf2 phase II detoxification pathway...
  65. ncbi Acute flaccid paralysis in infants and young children with enterovirus 71 infection: MR imaging findings and clinical correlates
    C Y Chen
    Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan, Republic of China
    AJNR Am J Neuroradiol 22:200-5. 2001
    ..AND PURPOSE: Enterovirus 71 (EV71) infection is now considered an important cause of childhood acute flaccid paralysis. The purpose of our study was to determine whether EV71-infection-related acute flaccid paralysis in infants and ..
  66. doi Sensorimotor cortical activation in patients with cervical spinal cord injury with persisting paralysis
    Michael T Jurkiewicz
    Toronto Rehabilitation Institute, Toronto, Canada
    Neurorehabil Neural Repair 24:136-40. 2010
    ..It is well documented that cortical sensorimotor representations are altered following nervous system pathology. However, little is known about these representations over time and, more specifically, in paralyzed individuals...
  67. pmc Surveillance of acute flaccid paralysis in the Marches region (Italy): 1997-2007
    Marcello M D'Errico
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Italy
    BMC Infect Dis 8:135. 2008
    ..and surveillance for wild poliovirus through reporting and laboratory testing of all cases of acute flaccid paralysis (AFP) among children under fifteen years of age...
  68. ncbi A poliomyelitis-like syndrome from West Nile virus infection
    A Arturo Leis
    N Engl J Med 347:1279-80. 2002
  69. ncbi Pathophysiology of human paralytic rabies
    Thiravat Hemachudha
    Department of Medicine and the Molecular Biology Laboratory for Neurological Diseases, Chulalongkorn University Hospital, Bangkok 10330, Thailand
    J Neurovirol 11:93-100. 2005
    ..Longer survival period in paralytic rabies may possibly be related to currently unidentified mechanism(s) on neuronal gene expression, required for virus transcription/replication and for maintaining neuronal survival...
  70. pmc Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis
    Susan K Grimston
    Division of Bone and Mineral Disease, Department of Internal Medicine, St Louis, MO 63110, USA
    J Bone Miner Res 26:2151-60. 2011
    ..in the effect of mechanical unloading, we have used botulinum toxin A (BtxA) to induce reversible muscle paralysis in mice with a conditional deletion of the Cx43 gene in osteoblasts and osteocytes (cKO)...
  71. ncbi Dynamics of motor nerve terminal remodeling unveiled using SNARE-cleaving botulinum toxins: the extent and duration are dictated by the sites of SNAP-25 truncation
    Frederic A Meunier
    Centre for Neurobiochemistry, Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK
    Mol Cell Neurosci 22:454-66. 2003
    ....
  72. pmc Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin
    Orhan Aktas
    Institute of Neuroimmunology, Neuroscience Research Center, NWFZ 2680, Charite, 10098 Berlin, Germany
    J Exp Med 197:725-33. 2003
    ..However, early T cell activation was unaffected, as reflected by unaltered calcium fluxes. Thus, our results provide evidence for a beneficial role of statins in the treatment of autoimmune attack on the CNS...
  73. pmc Brain-computer interfaces and communication in paralysis: extinction of goal directed thinking in completely paralysed patients?
    A Kubler
    Clinical and Health Psychology Research Centre, School of Human and Life Sciences, Roehampton University, Whitelands College, Holybourne Avenue, London SW15 4JD, UK
    Clin Neurophysiol 119:2658-66. 2008
    ..To investigate the relationship between physical impairment and brain-computer interface (BCI) performance...
  74. ncbi Impairment of slow inactivation as a common mechanism for periodic paralysis in DIIS4-S5
    S Bendahhou
    Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah, Salt Lake City 84112, USA
    Neurology 58:1266-72. 2002
    ..This article describes the clinical manifestations of a patient with hyperKPP carrying a mutation (L689I) occurring in the linker DIIS4-S5 and its functional expression in a mammalian system...
  75. pmc Axonal transport mediates West Nile virus entry into the central nervous system and induces acute flaccid paralysis
    Melanie A Samuel
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:17140-5. 2007
    West Nile virus (WNV) has emerged as a significant cause of epidemic viral encephalitis and flaccid limb paralysis, yet the mechanism by which it enters the CNS remains uncertain...
  76. doi The brain under self-control: modulation of inhibitory and monitoring cortical networks during hypnotic paralysis
    Yann Cojan
    Department of Neuroscience, University Medical School, University of Geneva, Geneva, Switzerland
    Neuron 62:862-75. 2009
    ..To assess motor and inhibitory brain circuits during hypnotic paralysis, we designed a go-no-go task while volunteers underwent functional magnetic resonance imaging (fMRI) in three ..
  77. ncbi Neurologic manifestations and outcome of West Nile virus infection
    James J Sejvar
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, and Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 290:511-5. 2003
    ..The neurologic manifestations, laboratory findings, and outcome of patients with West Nile virus (WNV) infection have not been prospectively characterized...
  78. ncbi Increased self-monitoring during imagined movements in conversion paralysis
    Floris P de Lange
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Kapittelweg 29, 6500 HB Nijmegen, The Netherlands
    Neuropsychologia 45:2051-8. 2007
    Conversion paralysis is characterized by a loss of voluntary motor functioning without an organic cause. Despite its prevalence among neurological outpatients, little is known about the neurobiological basis of this motor dysfunction...
  79. ncbi Lingual and pharyngeal paralysis due to acute doxycycline intoxication in veal calves
    K Chiers
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Rec 155:25-6. 2004
  80. doi Brain Painting: usability testing according to the user-centered design in end users with severe motor paralysis
    Claudia Zickler
    Institute of Medical Psychology and Behavioural Neurobiology, University of Tubingen, Silcherstr 5, D 72076 Tubingen, Germany
    Artif Intell Med 59:99-110. 2013
    For many years the reestablishment of communication for people with severe motor paralysis has been in the focus of brain-computer interface (BCI) research. Recently applications for entertainment have also been developed...
  81. ncbi Isolated sleep paralysis elicited by sleep interruption
    T Takeuchi
    Department of Psychology, Waseda University, Tokyo, Japan
    Sleep 15:217-25. 1992
    We elicited isolated sleep paralysis (ISP) from normal subjects by a nocturnal sleep interruption schedule...
  82. ncbi Motor evoked potentials in predicting recovery from upper extremity paralysis after acute stroke
    Henk T Hendricks
    Department of Rehabilitation Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Cerebrovasc Dis 16:265-71. 2003
    ..The use of motor evoked potentials (MEPs) in predicting recovery after stroke still appears to be somehow equivocal. We assessed the prognostic value of MEPs with respect to arm and hand motor recovery in acute stroke patients...
  83. ncbi Quantitative analysis of poliomyelitis-like paralysis in mice induced by a poliovirus replicon
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 87:3317-27. 2006
    Poliovirus (PV) infection causes severe paralysis, typically of the legs, by destruction of the motor neurons in the spinal cord...
  84. doi Immunopathology and Th1/Th2 immune response of Campylobacter jejuni-induced paralysis resembling Guillain-Barré syndrome in chicken
    Kishan K Nyati
    Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India
    Med Microbiol Immunol 201:177-87. 2012
    ..The study provides evidence that C. jejuni infection in the chicken can provide an experimental animal model of GBS...
  85. ncbi Effect of frequency and pulse duration on human muscle fatigue during repetitive electrical stimulation
    Trisha Kesar
    Department of Physical Therapy, 301 McKinly Laboratory, University of Delaware, Newark, DE 19716, USA
    Exp Physiol 91:967-76. 2006
    ..The results suggest that if the frequency and intensity are kept constant during FES, using the lowest frequency and longest pulse duration may maximize performance...
  86. ncbi Tonic immobility and childhood sexual abuse: a preliminary report evaluating the sequela of rape-induced paralysis
    Jennifer M Heidt
    Department of Psychology, Temple University, Weiss Hall 265 66, Philadelphia, PA 19122 6085, USA
    Behav Res Ther 43:1157-71. 2005
    ..The implications of these findings are discussed, and suggestions for future research are offered...
  87. ncbi Surveillance of acute flaccid paralysis in Hong Kong: 1997 to 2002
    R M K Lam
    Centre for Health Protection, Department of Health, Hong Kong
    Hong Kong Med J 11:164-73. 2005
    To describe the characteristics of patients reported with acute flaccid paralysis between 1997 and 2002, and to evaluate the performance of the acute flaccid paralysis surveillance system using indicators recommended by the World Health ..
  88. pmc Temperature-sensitive mutations in Drosophila melanogaster. VII. A mutation (para-ts) causing reversible adult paralysis
    D T Suzuki
    Proc Natl Acad Sci U S A 68:890-3. 1971
    A temperature-sensitive mutation, para(ts), in Drosophila melanogaster causes an immediate, but reversible, paralysis of adult flies when they are shifted from 22 degrees C to 29 degrees C...
  89. pmc Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila
    D D Hurd
    Department of Biology, Indiana University, Bloomington 47405, USA
    Genetics 144:1075-85. 1996
    ..These physiological defects cause progressive distal paralysis in larvae...
  90. ncbi Variations in injury patterns, treatment, and outcome for spinal fracture and paralysis in adult versus geriatric patients
    Zareth N Irwin
    Department of Orthopedics and Rehabilitation, Oregon Health and Science University, Portland 97201, USA
    Spine (Phila Pa 1976) 29:796-802. 2004
    ..Retrospective cohort analysis of hospital discharge and mortality data for spinal fracture and spinal cord injury patients in a single state from 1990 to 1995...
  91. ncbi Vascular endothelial growth factor prevents paralysis and motoneuron death in a rat model of excitotoxic spinal cord neurodegeneration
    Luis B Tovar-y-Romo
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico
    J Neuropathol Exp Neurol 66:913-22. 2007
    ..AMPA infusion produced dose-dependent progressive hindlimb motor deficits, reaching complete bilateral paralysis in approximately 10 days, which was correlated with the loss of spinal motoneurons...
  92. doi Risk factors for neonatal brachial plexus paralysis
    Rania Okby
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, P O Box 151, Be er Sheva, Israel
    Arch Gynecol Obstet 286:333-6. 2012
    The study was aimed to identify risk factors for neonatal brachial plexus paralysis.
  93. ncbi Adaptive response of human tendon to paralysis
    Constantinos N Maganaris
    Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager ST7 2HL, United Kingdom
    Muscle Nerve 33:85-92. 2006
    To gain insight into the adaptive response of human tendon to paralysis, we compared the mechanical properties of the in vivo patellar tendon in six men who were spinal cord-injured (SCI) and eight age-matched, able-bodied men...
  94. ncbi West Nile virus encephalomyelitis with polio-like paralysis & nigral degeneration
    Kristian T Schafernak
    Division of Neuropathology, Northwestern University Feinberg School of Medicine, 710 N Fairbanks Court, Olson 3 459, Chicago, Illinois 60611, USA
    Can J Neurol Sci 33:407-10. 2006
    ..may develop acute neurologic disease, which can be severe or even fatal, including WNV meningitis, encephalitis, and an irreversible acute flaccid paralysis or poliomyelitis-like syndrome. Movement disorders have also been described.
  95. ncbi Complete paralysis of the quadriceps muscle caused by traumatic iliacus hematoma: a case report
    Kazuya Tamai
    Department of Orthopaedic Surgery, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga gun, Tochigi 321 0293, Japan
    J Orthop Sci 7:713-6. 2002
    A15-year-old girl who developed traumatic iliacus hematoma and complete paralysis of the quadriceps muscle is reported...
  96. pmc Surgical treatment of winged scapula
    Gregory J Galano
    Center for Shoulder, Elbow and Sports Medicine, Columbia University Medical Center, 622 West 168th Street, New York, NY 10032, USA
    Clin Orthop Relat Res 466:652-60. 2008
    ..5), and visual analog scale (5.0-2.9). We encountered two complications, both superficial wound infections. These tendon transfers were effective for treating scapular winging in patients who did not respond to nonoperative treatment...
  97. ncbi Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps
    M Adler
    Neurotoxicology Branch, Pharmacology Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Toxicon 38:1381-8. 2000
    The ability of 3,4-diaminopyridine (3,4-DAP) to antagonize muscle paralysis following local injection of botulinum neurotoxin A (BoNT/A) complex was evaluated in the in situ rat extensor digitorum longus (EDL) preparation...
  98. pmc Effects of botulinum toxin-induced paralysis on postnatal development of the supraspinatus muscle
    Rosalina Das
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, USA
    J Orthop Res 29:281-8. 2011
    ..An intramuscular injection of botulinum toxin type A (BTX) was used to induce and maintain paralysis in the left shoulders of mice since birth while the right shoulders received saline and served as contralateral ..
  99. doi Tubular aggregates in paralysis periodica paramyotonica with T704M mutation of SCN4A
    Xinghua Luan
    Department of Neurology and Laboratory of Neuropathology, Peking University First Hospital, 8 Xishiku St, Xicheng District, Beijing 100034, China
    Neuropathology 29:579-84. 2009
    T704M mutations in SCN4A have recently been identified in families with paralysis periodica paramyotonica...
  100. doi Transient host paralysis as a means of reducing self-superparasitism in koinobiont endoparasitoids
    Nicolas Desneux
    Department of Entomology, University of Minnesota, 1980 Folwell Avenue, Saint Paul, MN 55108, USA
    J Insect Physiol 55:321-7. 2009
    ..While no koinobiont species induce permanent paralysis in their hosts, a minority of koinobionts induce a temporary paralysis that does not interfere with overall host ..
  101. doi Photodynamic therapy with indocyanine green injection and near-infrared light irradiation has phototoxic effects and delays paralysis in spinal metastasis
    Toru Funayama
    Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Photomed Laser Surg 30:47-53. 2012
    ....

Research Grants78

  1. Dynamic Vocal Fold Abduction for Bilateral Paralysis
    Michael Broniatowski; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Bilateral vocal cord paralysis is a life threatening condition due to the inability of the larynx (voice box) to open during inspiration...
  2. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..Muscle paralysis and blunted hypercapnic ventilatory responsiveness in persons with tetraplegia, which are also normal rapid eye ..
  3. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..is widespread and many veterans suffer from injuries or diseases that limit dynamic exercise: amputation, paralysis, peripheral vascular disease, cardiopulmonary disorders, and even depression...
  4. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..overload of excitotoxic chemicals incapacitates the victim via cholinergic toxidrome, resulting in seizures, paralysis, mucous secretions, eye irritation, cardiorespiratory depression, GI distress, and eventually, death...
  5. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..Although termed "mild" in comparison to brain injuries resulting in death, coma, or paralysis, mTBI, particularly repetitive mTBI characteristic of soldiers deployed to Operation Iraqi Freedom (OIF) and ..
  6. Epigenetic mechanisms relevant to the pathogenesis of ALS
    Neil W Kowall; Fiscal Year: 2013
    ..provided by applicant): Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by progressive paralysis due to motor neuron degeneration. Many therapies have been tested but no cure or effective therapy is available...
  7. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
    ..In North America, the bites of some species of Dermacentor can result in paralysis in humans and domestic animals...
  8. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..barrier (BBB), enter the CNS and trigger inflammation, thereby causing demyelination and induction of paralysis. Studies from our laboratory have demonstrated that naove T cells express the standard form of CD44 (CD44s) and ..
  9. The Role of Interleukin-10 During Fatal Alphavirus Encephalomyelitis
    KIRSTEN KULCSAR; Fiscal Year: 2013
    ..Viral clearance correlates with the onset of paralysis suggesting that the immune response is causing pathology, not viral replication...
  10. Robust Peptide-Based Diagnostics of Botulinum Toxins
    John E Mueller; Fiscal Year: 2012
    ..10 [unreadable]g) of the toxin could be extremely fatal to an adult;lower doses can result in partial muscle paralysis. Of the seven serotypes (A-G), only types A, B, E, and F are known to be pathogenic in humans...
  11. Role of Potent Trophic Factors on Glia and Motor Neurons in ALS
    Brian K Kaspar; Fiscal Year: 2013
    Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease, which results in muscle paralysis and ultimate respiratory failure and death. The underlying cause for ALS remains unknown with no cure...
  12. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2013
    ..They cause significant morbidity including deafness, tinnitus, facial paralysis, imbalance, and brainstem compression...
  13. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..This shiver response must be counteracted (such as by muscle paralysis) to allow body cooling and also to avoid clinical complications that accompany prolonged shivering such as ..
  14. The Role of the Terminal Complement Pathway in ALS
    Scott R Barnum; Fiscal Year: 2013
    ..that leads to degeneration of motor neurons in the cortex, brainstem and spinal cord resulting in progressive paralysis and ultimately death...
  15. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..characterized by inflammation in the central nervous system that results in neuron demyelination leading to paralysis. Dietary indoles including indole-3-carbinol (I3C) found in cruciferous vegetables such as cauliflower, cabbage ..
  16. Glutathione in mitochondrial dysfunction and disease progression in ALS-models
    Marcelo R Vargas; Fiscal Year: 2011
    ..disease is characterized by the specific death of the nerve cells that control muscle movement, leading to paralysis and eventual death...
  17. Respiratory motor control and blood pressure regulation after spinal cord injury
    ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013
    ..Another common impediment to rehabilitation after SCI is respiratory insufficiency due to paresis and paralysis of respiratory muscles. Physiologically, these respiratory and cardiovascular dysfunctions are closely related...
  18. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
    ..These investigations promise to provide new insights into the mechanisms by which anthrax toxins mediate paralysis of the immune system, and are likely to provide new strategies for the diagnosis and treatment of systemic ..
  19. Enterovirus RNA Translation and Replication
    David J Barton; Fiscal Year: 2013
    ..Poliovirus and related human enteroviruses cause a diverse spectrum of human diseases including acute flaccid paralysis (paralytic poliomyelitis), aseptic meningitis, myocarditis, conjunctivitis and fatal systemic infections of ..
  20. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Cassava (manioc) contains toxic compounds e.g. linamarin that are incriminated in the paralysis of legs (disease is called konzo) and other diseases of the nervous system across the lifespan...
  21. Presynaptic Mechanisms Regulating the Dopamine Transporter
    JAMES A HARDAWAY; Fiscal Year: 2013
    ..by pharmacological or genetic loss of DAT (DAT-1) induces a locomotory phenotype called Swimming Induced Paralysis (SWIP)...
  22. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2013
    ..PLP) can induce severe signs of experimental autoimmune encephalomyelitis (EAE) in mice that include ascending paralysis, demyelination and axonal damage...
  23. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..has been extensively studied in able-bodied non-human primates, but less so in humans with prolonged and severe paralysis. The central hypothesis of this proposal is that cortical signals in humans with impaired movement reliably ..
  24. ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    Don W Cleveland; Fiscal Year: 2010
    ..adult-onset neurodegenerative disorder in which premature loss of upper and lower motor neurons leads to fatal paralysis with a typical disease course of one to five years...
  25. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William A Catterall; Fiscal Year: 2013
    ..Impairment of Na channel function causes periodic paralysis, epilepsy, chronic pain, migraine, and cardiac arrhythmia...
  26. Redox Regulation of Lung Mitochondrial Biogenesis in Sepsis/Pneumonia
    Claude A Piantadosi; Fiscal Year: 2013
    ..episode of severe sepsis and ARDS/multiple organ dysfunction syndrome (MODS), but die with so- called "immune paralysis" characterized by effector cell apoptosis, anti-inflammatory cytokine over-expression, suppression of pro-..
  27. Dysfunction of neurofilaments in disease: an iPS model of Giant Axonal Neuropathy
    BETHANY LESLIE JOHNSON-KERNER; Fiscal Year: 2012
    ..In these patients, degeneration of motor neurons (MNs) leads to progressive paralysis and death by the third decade of life...
  28. HEREDITARY DEFECTS IN HUMAN SODIUM CHANNELS
    Alfred L George; Fiscal Year: 2013
    ..A variety of inherited disorders affecting skeletal muscle contraction (hyperkalemic periodic paralysis, paramyotonia congenita, K+-aggravated myotonia), cardiac excitability (congenital long QT syndrome, idiopathic ..
  29. Improving ambulatory community access after paralysis
    Rudi Kobetic; Fiscal Year: 2012
    ..instability and increase walking speed to improve ambulatory community access of persons with lower extremity paralysis due to incomplete spinal cord injury (ISCI)...
  30. A Spontaneous Mouse Model of Motor Neuron Disease
    Kevin L Seburn; Fiscal Year: 2011
    ..displays overt, progressive loss of neuromuscular function, particularly in the hind limbs, with almost complete paralysis by 5-6 months of age...
  31. Proteolytic Pathways in Thrombus Resolution
    Toni M Antalis; Fiscal Year: 2013
    ..Common risk factors for DVT include cancer, major trauma, surgery, paralysis, prolonged periods of immobility, and older age...
  32. Neurotrophin-Secreting Muscle Stem Cell Therapy for Laryngeal Paralysis
    Stacey L Halum; Fiscal Year: 2013
    ..to pursue an academic research career investigating the pathophysiology and therapeutic options for vocal fold paralysis and other laryngologic disorders...
  33. Innate Regulation and CD4+Th1/17 Immunity in TMEV-Induced Demyelination
    Stephen D Miller; Fiscal Year: 2013
    ..disorder which is related to life-long persistent CNS virus infection and characterized by spastic hind limb paralysis. In contrast, resistant C57BL/6 mice make a potent CTL response and rapidly clear the infection...
  34. CD-73 adenosine signaling in the central nervous system in disease and health
    Margaret S Bynoe; Fiscal Year: 2012
    ..the CNS and mount immune responses against myelin components, resulting in neuronal damage that can cause paralysis and even death...
  35. Ca2+ mishandling and ischemia-vulnerability in fALS model motor terminals
    Gavriel David; Fiscal Year: 2012
    ..Treatments to preserve remaining motor nerve terminals should slow the progression of paralysis, and thus may become an important new component of therapies for treating ALS.
  36. Orexin Receptor Agonists for the Treatment of Excessive Daytime Sleepiness and Ca
    PAUL STUART HUMPHRIES; Fiscal Year: 2013
    ..daytime sleepiness (EDS), cataplexy (sudden bilateral loss of muscle tone), hypnagogic hallucination and sleep paralysis. Narcolepsy affects approximately 150,000 people in the US and has a negative effect on the quality of life of ..
  37. NEUROBIOLOGY OF VARICELLA ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 2013
    ..PHN, chronic pain), as well as retinitis, myelitis and vasculopathy, which are significant causes of blindness, paralysis and death...
  38. HDAC6: a target for regeneration following injury in the nervous system
    BRETT CAMERON LANGLEY; Fiscal Year: 2013
    ..regenerative neuroscience is that patients with spinal cord injury suffer from permanent functional deficits and paralysis because of neural damage, but also because of a limited capacity of CNS axons to regenerate and restore lost ..
  39. Neuronal RNA processing defects in ALS4 caused by SETX mutations
    Craig L Bennett; Fiscal Year: 2013
    ..The L389S KI-mice show a more severe but later onset hind-limb paralysis (~ 12-13 months age) with apparent reduced survival rates...
  40. Vitamin D and the Immune System
    Lawrence Steinman; Fiscal Year: 2012
    ..Our preliminary results have shown a direct suppression of IL-17 by 1,25(OH)2D3 as well as reversal of paralysis and inhibition of progression of EAE [a murine model of multiple sclerosis (MS)] by 1,25(OH)2D3 which is ..
  41. Defining a clinically relevant time point for astrocyte targeted therapy in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..It is a devastating motor neuron (MN) disease, resulting in muscle paralysis and ultimately respiratory failure leading to death...
  42. Mechanisms of degeneration in the spinal cord and musculoskeletal system in SMA
    SANIYA FAYZULLINA; Fiscal Year: 2013
    ..It is characterized by progressive symmetrical limb and trunk paralysis and muscular atrophy...
  43. The Functional Role of RBM45 in Gene Expression and Neurodegeneration
    Mahlon Collins; Fiscal Year: 2013
    ..of motor neurons of the corticospinal tract, resulting in a numerous debilitating symptoms culminating with paralysis and death...
  44. South Carolina Study for Adolescents and Young Adults with Rare Conditions
    SUZANNE W MCDERMOTT; Fiscal Year: 2013
    ..incidence and prevalence of co-morbid and secondary conditions and the co-occurrence of intellectual disability, paralysis, epilepsy, attention deficit hyperactivity disorder, and other conditions...
  45. Low-cost handheld medical device for neuroaxial anesthesia guidance in the obese
    FRANK WILLIAM MAULDIN; Fiscal Year: 2012
    ..health complications: headache, hematoma, backpain, vascular puncture, pleural puncture, pneumothorax, and paralysis. Alternative approaches to the blind method include fluoroscopy and ultrasound guidance...
  46. Pre-clinical testing of necrostatin as a potential small molecule for the treatme
    SERGE E PRZEDBORSKI; Fiscal Year: 2012
    ..necrostatin blocks the deleterious effects of specific inflammatory cells on the nerve cells responsible for ALS paralysis. Herein, we propose to determine the suitability of using this small molecule is a living organism and to ..
  47. Lyme neuroborreliosis pathogenesis in the rhesus monkey
    MARIO TOMAS PHILIPP; Fiscal Year: 2013
    ..is a form of Lyme disease that affects both the peripheral and central nervous systems, causing facial paralysis, nerve pain, sensory loss, weakness, meningitis, neurocognitive abnormalities, and loss of memory...
  48. Campylobacter jejuni outer membrane protein vaccine
    Stuart Thompson; Fiscal Year: 2009
    ..is also the most common antecedent event to the development of Guiilain-Barre Syndrome (GBS), an acute motor paralysis that apparently results from an autoimmune response directed against C. jejuni surface antigens...
  49. Immunomodulatory Roles of Amyloid-Beta and Amyloid Precursor Protein in CNS Autoi
    JACQUELINE LEIGH GRANT; Fiscal Year: 2012
    ..EAE), an animal model of MS, I have found that in vivo administration of A[unreadable]42 attenuates ascending paralysis, reduces inflammatory lesions in the brain and spinal cord, and suppresses peripheral immune cell activation...
  50. Proinflammatory enzymes in amytrophic lateral sclerosis
    SERGE E PRZEDBORSKI; Fiscal Year: 2012
    ..a dish that specific inflammatory cells produce factors capable of killing the nerve cells responsible for ALS paralysis. Herein, we propose to;search for this toxic factor;to demonstrate by which mechanism it kills cells;and to ..
  51. Combined Stem Cell and Anti-Oxidative Therapy for ALS
    Jason R Thonhoff; Fiscal Year: 2010
    ..Most ALS patients develop limb weakness initially, which progresses quickly to generalized muscle atrophy and paralysis. Death occurs within 5 years, usually due to respiratory failure...
  52. Astrocyte dysfunction in EAE
    David N Irani; Fiscal Year: 2012
    ..cord TSP-1 levels fall rapidly and then recover in parallel to the appearance and disappearance of hind limb paralysis during relapsing experimental autoimmune encephalomyelitis (EAE), an established rodent model of the human ..
  53. Local Circuit Properties of Mouse Corticospinal Neurons
    Patrick L Sheets; Fiscal Year: 2011
    ..by applicant): Neuropathology affecting primary motor cortex (M1) causes major neurological impairment including paralysis/paraplegia, epilepsy, and movement disorders including amyotrophic lateral sclerosis (ALS), a disease affecting ..
  54. Novel RNAi therapy for ALS and other Neurodegenerative Disorders
    Lyn Libertine; Fiscal Year: 2011
    ..Degeneration of the motor neurons results in paralysis and eventual death, usually due to respiratory failure...
  55. MOLECULAR BASIS OF CONGENITAL STRABISMUS
    Elizabeth C Engle; Fiscal Year: 2013
    ..While each mutation causes CFEOM3, some also result in axonal neuropathy, facial paralysis, intellectual and behavioral impairments, and/or endocrine dysfunction...
  56. Prevention of VZV Reactivation
    Randall J Cohrs; Fiscal Year: 2013
    ..400,000 Americans still develop zoster every year, of which about 200,000 experience PHN;others develop stroke, paralysis and blindness. None of these neurological disorders would occur if virus reactivation could be prevented...
  57. The Nrf2-ARE Pathway in Amyotrophic Lateral Sclerosis
    Jeffrey A Johnson; Fiscal Year: 2013
    ..hSOD1G93A mice on GCLM-/- background show dramatic muscle weakness (0 sec on wire hang) and initial signs of paralysis by 45 days of age compared to 120 days of age on a GCLM+/+ background...
  58. Manipulating Macrophage Phenotype in Laryngeal Nerve Repair
    Jonathan Cheetham; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vocal fold paralysis occurs when the recurrent laryngeal nerve (RLN) is injured, most commonly during surgery of the neck or thorax...
  59. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..may be related to the degree of neurologic impairment or to chronic immobilization secondary to skeletal muscle paralysis. It is important to address the secondary complications of neurologic impairment and paralysis in order to ..
  60. Receptors for clostridial neurotoxins
    Edwin R Chapman; Fiscal Year: 2010
    ..This can result in paralysis and death...
  61. Role of CX3CR1 in adaptive immunity during autoimmune encephalomyelitis
    Astrid E Cardona; Fiscal Year: 2013
    ..absence of CX3CR1 in bone marrow induced an unusual, severe and chronic non-remitting EAE disease with sustained paralysis. The overall goal of this proposal is to elucidate the function of CX3CR1 during EAE and how it regulates ..
  62. Roles of voltage sensor, S100A1 and calmodulin in skeletal muscle Ca2+ signaling
    Martin F Schneider; Fiscal Year: 2013
    ..marked suppression of muscle Ca2+ release in a transgenic mouse model expressing a hypokalemic periodic paralysis (hypoPP) CaV1...
  63. Recurrent laryngeal nerve connective tissues as a factor in vocal fold paralysis
    Julie M Barkmeier-Kraemer; Fiscal Year: 2013
    ..laryngeal branch (RLN) of the vagus nerve to formulate their role in the onset of unilateral vocal fold paralysis (UVP)...
  64. MOLECULAR AND GENETIC ANALYSIS OF GPR126 IN PERIPHERAL NERVE.
    Kelly R Monk; Fiscal Year: 2013
    ..devastating symptoms, significant morbidity, and myelin loss can lead to permanent neuron loss, and ultimately, paralysis. Currently, no treatments exist to prevent demyelination or to hasten remyelination, and there is therefore a ..
  65. Protection against acute inflammatory demyelinating peripheral nerve disease
    EVAN STUBBS; Fiscal Year: 2009
    ..system that is characterized by rapid-onset symmetrical paresis with areflexia progressing to neuromuscular paralysis. Considered the leading cause of acute flaccid paralysis in Western countries, GBS occurs with an incidence rate ..
  66. Adjustable balloon implant for medialization thyroplasty
    Matthew R Hoffman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Vocal fold paralysis (VFP) is a disorder caused by damage to the recurrent laryngeal nerve. VFP impairs breathing, swallowing, and vocal function...
  67. Bell's Palsy-Randomized Clinical Trial
    John Neely; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Bell's palsy, the sudden onset of unilateral facial paralysis without identifiable cause involving all branches of the facial nerve, affects approximately 23/100,000 people each ..
  68. Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
    Anthony F DiMarco; Fiscal Year: 2010
    ..These individuals lack an effective cough mechanism due to the fact that their injury often results in paralysis of virtually all of their expiratory muscles...
  69. Pulmonary Biomarkers of Inflammation in Chronic Tetraplegia
    Miroslav Radulovic; Fiscal Year: 2009
    Persons with tetraplegia exhibit pulmonary dysfunction attributed to paralysis of respiratory muscles leading to inadequate ventilation and inability to clear secretions, predisposing this population to be more susceptible to repeated ..
  70. BOTULINUM NEUROTOXIN: MECHANISM OF TOXICITY
    BIBHUTI DASGUPTA; Fiscal Year: 1991
    ..Consequently flaccid muscle paralysis occurs...
  71. The UAB Spina Bifida Patient Registry Demonstration Project
    David B Joseph; Fiscal Year: 2010
    ..born with Spina Bifida face a number of obstacles including hydrocephalus in more that 90% of cases, as well as paralysis and weakness of the extremities and decreased bladder/bowel control...
  72. Adrenergic Control of Stem Cell Lineage Commitment in Sepsis
    KUZHALI MUTHUMALAIAPPAN; Fiscal Year: 2009
    ..This phase of immune-paralysis renders the critically injured patients succumb to nosocomial infections...
  73. RNA aptamers as novel antidotes against botulism
    Shuowei Cai; Fiscal Year: 2009
    ..The flaccid paralysis caused by botulism lasts for months...
  74. Characterization of Endpoint Mechanical Actions of Thumb Muscles
    Joseph D Towles; Fiscal Year: 2011
    ..The ability to work and quality of life are often impacted and, in the most severe cases of hand muscle paralysis, adductorplasty and opponensplasty tendon transfer surgeries can be used to restore lateral and opposition pinch ..
  75. Development and Translational Assesment of a Tongue-Based Assistive Neuro-Technol
    Maysam Ghovanloo; Fiscal Year: 2010
    ..ANT) for Individuals with Severe Neurological Disorders More than two million Americans suffer from paralysis as a result of accidents, acts of violence, and neurological diseases...
  76. Spinal Cord Stimulation to Restore Cough In Humans
    Anthony DiMarco; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Patients with cervical and thoracic spinal cord injuries have paralysis of a major portion of their expiratory muscles and therefore, lack a normal cough mechanism...
  77. MaqFACS: Measuring expressive movement in monkeys
    Lisa Parr; Fiscal Year: 2009
    ..understanding affective disorders of the face, including emotional expression deficits, various modes of facial paralysis, and specific speech disorders, researchers must describe the motor-component of the deficit...
  78. CRICOTHYROID REFLEX/RECURRENT LARYNGEAL NERVE PARALYSIS
    Gayle Woodson; Fiscal Year: 1992
    The proposed research will test the hypothesis that airway obstruction in bilateral recurrent laryngeal nerve paralysis is due to reflex stimulation of the cricothyroid muscle, and that suppression of this reflex would significantly ..